SIMILAR PATTERNS OF AMINO ACIDS FOR 4FGL_D_CLQD303_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azz COLLAGENASE

(Leptuca
pugilator) 		PF00089
(Trypsin) 		5 ASN A  25
GLY A  69
GLN A  80
ILE A  73
PHE A  34
 None
 1.49A 4fglC-1azzA:
undetectable		 4fglC-1azzA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri) 		PF00089
(Trypsin) 		4 GLY A  44
VAL A  31
PHE A 209
ILE A  47
 None
 0.66A 4fglC-1bqyA:
undetectable		 4fglC-1bqyA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy2 COLLAGEN ALPHA1(XV)
CHAIN

(Mus musculus) 		PF06482
(Endostatin) 		4 ASN A 196
GLY A 199
VAL A 200
PHE A 139
 None
 0.75A 4fglC-1dy2A:
undetectable		 4fglC-1dy2A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Leishmania
mexicana) 		PF00274
(Glycolytic) 		4 VAL A 112
PHE A  78
ILE A  82
PHE A 337
 None
 0.77A 4fglC-1epxA:
0.5		 4fglC-1epxA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00274
(Glycolytic) 		4 VAL A 112
PHE A  78
ILE A  82
PHE A 337
 None
 0.77A 4fglC-1f2jA:
undetectable		 4fglC-1f2jA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f7u ARGINYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 GLY A 207
PHE A 269
ILE A 265
PHE A 196
 None
 0.92A 4fglC-1f7uA:
4.4		 4fglC-1f7uA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hus RIBOSOMAL PROTEIN S7

(Geobacillus
stearothermophilus) 		PF00177
(Ribosomal_S7) 		5 GLY A  99
VAL A  68
PHE A  61
ILE A 123
PHE A  46
 None
 1.48A 4fglC-1husA:
undetectable		 4fglC-1husA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ASN A  49
GLY A  51
PHE A  79
ILE A  83
 None
 0.91A 4fglC-1i2dA:
1.9		 4fglC-1i2dA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j93 UROPORPHYRINOGEN
DECARBOXYLASE

(Nicotiana
tabacum) 		PF01208
(URO-D) 		4 GLY A 164
VAL A 103
ILE A  92
PHE A 190
 None
 0.87A 4fglC-1j93A:
undetectable		 4fglC-1j93A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		4 ASN A 646
VAL A  27
ILE A  30
PHE A 687
 None
 0.88A 4fglC-1kehA:
undetectable		 4fglC-1kehA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kj9 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE 2

(Escherichia
coli) 		PF02222
(ATP-grasp) 		4 GLY A 196
VAL A 197
ILE A 168
PHE A 141
 EDO  A 402 ( 3.2A)
ATP  A   1 (-3.9A)
None
None
 0.77A 4fglC-1kj9A:
3.7		 4fglC-1kj9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		5 ASN A 634
GLY A 594
VAL A 595
ILE A 606
PHE A 517
 None
 1.50A 4fglC-1lzxA:
undetectable		 4fglC-1lzxA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE

(Klebsiella sp.
LX3) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLY A 593
VAL A 594
ILE A 395
PHE A 551
 None
 0.92A 4fglC-1m53A:
undetectable		 4fglC-1m53A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1op2 VENOM SERINE
PROTEINASE

(Deinagkistrodon
acutus) 		PF00089
(Trypsin) 		4 GLY A  44
VAL A  31
PHE A 209
ILE A  47
 None
 0.71A 4fglC-1op2A:
undetectable		 4fglC-1op2A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orf GRANZYME A

(Homo sapiens) 		PF00089
(Trypsin) 		4 GLY A  44
VAL A  31
PHE A 209
ILE A  47
 None
 0.79A 4fglC-1orfA:
undetectable		 4fglC-1orfA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg5 ASPARTATE
CARBAMOYLTRANSFERASE

(Sulfolobus
acidocaldarius) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 GLY A 285
VAL A 286
ILE A 292
PHE A  10
 None
 0.81A 4fglC-1pg5A:
3.9		 4fglC-1pg5A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Homo sapiens) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 ASN A 463
GLY A 459
ILE A 536
PHE A 542
 None
 0.84A 4fglC-1pl0A:
undetectable		 4fglC-1pl0A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv9 XAA-PRO DIPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 GLY A  40
VAL A  53
PHE A  21
ILE A  78
PHE A 102
 None
 1.44A 4fglC-1pv9A:
undetectable		 4fglC-1pv9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxz PROTEIN (CU-ZN
SUPEROXIDE
DISMUTASE)

(Bos taurus) 		PF00080
(Sod_Cu) 		4 GLY A 145
VAL A 146
PHE A  20
ILE A 110
 None
 0.92A 4fglC-1sxzA:
undetectable		 4fglC-1sxzA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE

(Mycobacterium
bovis) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		4 GLY A 147
VAL A 146
ILE A 130
PHE A  67
 None
 0.92A 4fglC-1tdtA:
undetectable		 4fglC-1tdtA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF14519
(Macro_2) 		4 GLY A  79
PHE A 106
ILE A 143
PHE A 102
 APR  A 285 (-3.6A)
None
None
None
 0.79A 4fglC-1txzA:
undetectable		 4fglC-1txzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF14519
(Macro_2) 		4 VAL A 146
PHE A 106
ILE A 143
PHE A 102
 None
 0.76A 4fglC-1txzA:
undetectable		 4fglC-1txzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 GLY A 106
PHE A 201
ILE A 162
PHE A 129
 None
 0.87A 4fglC-1ty2A:
undetectable		 4fglC-1ty2A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tye INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 GLY B 221
PHE B 248
ILE B 226
PHE B 308
 None
 0.74A 4fglC-1tyeB:
4.8		 4fglC-1tyeB:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 2

(Bos taurus) 		PF00022
(Actin) 		4 GLY B 255
VAL B 241
ILE B 252
PHE B 204
 None
 0.92A 4fglC-1u2vB:
undetectable		 4fglC-1u2vB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		4 GLY A 132
VAL A 133
PHE A 144
ILE A 111
 None
 0.83A 4fglC-1vclA:
undetectable		 4fglC-1vclA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmo VITELLINE MEMBRANE
OUTER LAYER PROTEIN
I

(Gallus gallus) 		PF03762
(VOMI) 		4 GLY A  14
PHE A  87
ILE A 106
PHE A 159
 None
 0.90A 4fglC-1vmoA:
undetectable		 4fglC-1vmoA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Thermotoga
maritima) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ASN A 273
GLY A 294
PHE A   7
ILE A 337
 None
 0.88A 4fglC-1vrdA:
undetectable		 4fglC-1vrdA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A

(Pyrococcus
horikoshii) 		PF00117
(GATase) 		4 VAL A  64
PHE A  89
ILE A  85
PHE A 139
 None
 0.81A 4fglC-1wl8A:
4.9		 4fglC-1wl8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 GLY A 735
VAL A 795
PHE A 746
ILE A 760
 None
NAG  A5001 (-4.7A)
None
None
 0.85A 4fglC-1xc6A:
undetectable		 4fglC-1xc6A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc4 RAS-RELATED PROTEIN
RAL-A

(Homo sapiens) 		PF00071
(Ras) 		4 GLY A  21
VAL A  92
PHE A  83
ILE A  18
 None
 0.80A 4fglC-1zc4A:
4.7		 4fglC-1zc4A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00155
(Aminotran_1_2) 		4 GLY A 408
VAL A 407
PHE A 350
PHE A 352
 None
 0.74A 4fglC-2ay9A:
3.5		 4fglC-2ay9A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiq PUTATIVE TAGATOSE
6-PHOSPHATE KINASE 1

(Escherichia
coli) 		PF08013
(Tagatose_6_P_K) 		4 GLY A 281
VAL A 280
ILE A  43
PHE A  64
 None
 0.88A 4fglC-2fiqA:
undetectable		 4fglC-2fiqA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkk BASEPLATE STRUCTURAL
PROTEIN GP10

(Escherichia
virus T4) 		no annotation 4 ASN A 502
GLY A 517
PHE A 481
ILE A 428
 None
 0.80A 4fglC-2fkkA:
undetectable		 4fglC-2fkkA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3a ACETYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13673
(Acetyltransf_10) 		4 ASN A  38
GLY A  54
VAL A  53
GLN A  64
 None
 0.81A 4fglC-2g3aA:
undetectable		 4fglC-2g3aA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Aquifex
aeolicus) 		PF00308
(Bac_DnaA)
PF08299
(Bac_DnaA_C) 		4 ASN A 113
PHE A 195
ILE A 198
PHE A 151
 None
 0.91A 4fglC-2hcbA:
undetectable		 4fglC-2hcbA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Aquifex
aeolicus) 		PF00308
(Bac_DnaA)
PF08299
(Bac_DnaA_C) 		4 GLY A 234
PHE A 199
ILE A 209
PHE A 195
 None
 0.71A 4fglC-2hcbA:
undetectable		 4fglC-2hcbA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU

(Streptococcus
pneumoniae) 		PF01895
(PhoU) 		4 VAL A 205
PHE A 137
ILE A 200
PHE A  16
 None
 0.90A 4fglC-2i0mA:
undetectable		 4fglC-2i0mA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5k UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01704
(UDPGP) 		4 ASN A 317
GLY A 365
PHE A 220
ILE A 323
 None
 0.92A 4fglC-2i5kA:
undetectable		 4fglC-2i5kA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu5 HTH-TYPE DHAKLM
OPERON
TRANSCRIPTIONAL
ACTIVATOR DHAS

(Lactococcus
lactis) 		PF00440
(TetR_N) 		4 ASN A  67
GLN A 110
PHE A 106
ILE A 109
 None
 0.89A 4fglC-2iu5A:
undetectable		 4fglC-2iu5A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8s AGR_C_984P

(Agrobacterium
fabrum) 		PF06748
(DUF1217) 		4 ASN A 193
GLY A 195
VAL A 196
ILE A 271
 None
 0.90A 4fglC-2o8sA:
undetectable		 4fglC-2o8sA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odr PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanococcus
maripaludis) 		PF01409
(tRNA-synt_2d) 		4 GLY B 190
GLN B  81
PHE B  82
ILE B  78
 None
 0.81A 4fglC-2odrB:
undetectable		 4fglC-2odrB:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pae DTDP-6-DEOXY-3,4-KET
O-HEXULOSE ISOMERASE

(Aneurinibacillus
thermoaerophilus) 		PF05523
(FdtA) 		4 ASN A  49
GLY A  47
PHE A 100
ILE A  37
 None
 0.91A 4fglC-2paeA:
undetectable		 4fglC-2paeA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 ASN A 362
GLY A 338
VAL A 339
ILE A 248
 None
 0.86A 4fglC-2uvfA:
undetectable		 4fglC-2uvfA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w20 SIALIDASE A

(Streptococcus
pneumoniae) 		PF13088
(BNR_2) 		4 GLY A 567
VAL A 568
PHE A 436
ILE A 416
 None
 0.90A 4fglC-2w20A:
undetectable		 4fglC-2w20A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3y VIRULENCE FACTOR

(Pectobacterium
carotovorum) 		no annotation 4 GLY A 152
PHE A 198
ILE A 205
PHE A 219
 PLM  A1278 ( 4.2A)
None
None
PLM  A1278 ( 3.7A)
 0.88A 4fglC-2w3yA:
undetectable		 4fglC-2w3yA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03198
(Glyco_hydro_72)
PF07983
(X8) 		4 GLY A 212
VAL A 211
PHE A  43
ILE A  38
 None
 0.92A 4fglC-2w61A:
undetectable		 4fglC-2w61A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wb7 PT26-6P

(Thermococcus
sp. 26-2) 		no annotation 4 GLY A 475
PHE A 483
ILE A 433
PHE A 453
 None
 0.84A 4fglC-2wb7A:
undetectable		 4fglC-2wb7A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahy BETA-GLUCOSIDASE

(Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		5 GLY A 201
VAL A 286
PHE A 163
ILE A 196
PHE A 118
 None
 1.50A 4fglC-3ahyA:
undetectable		 4fglC-3ahyA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anx SPERMIDINE SYNTHASE

(Thermus
thermophilus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 VAL A  53
PHE A 234
ILE A 227
PHE A 236
 None
 0.85A 4fglC-3anxA:
2.9		 4fglC-3anxA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 GLY A 819
VAL A 818
GLN A 817
ILE A 813
PHE A 787
 None
None
WAN  A 901 (-3.1A)
WAN  A 901 ( 4.3A)
None
 1.46A 4fglC-3bjcA:
undetectable		 4fglC-3bjcA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A  82
VAL A  74
ILE A  71
PHE A 374
 None
 0.89A 4fglC-3bjsA:
undetectable		 4fglC-3bjsA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce1 SUPEROXIDE DISMUTASE
[CU-ZN]

(Naganishia
liquefaciens) 		PF00080
(Sod_Cu) 		4 GLY A 151
VAL A 152
PHE A  23
ILE A 116
 None
 0.88A 4fglC-3ce1A:
undetectable		 4fglC-3ce1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chl ALPHA-14 GIARDIN

(Giardia
intestinalis) 		PF00191
(Annexin) 		4 GLY A 301
VAL A 302
ILE A 307
PHE A 255
 None
 0.89A 4fglC-3chlA:
undetectable		 4fglC-3chlA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Enterococcus
faecalis) 		PF13377
(Peripla_BP_3) 		4 GLY A  63
VAL A  64
PHE A 127
ILE A 134
 None
 0.84A 4fglC-3cs3A:
5.3		 4fglC-3cs3A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddj CBS
DOMAIN-CONTAINING
PROTEIN

(Sulfolobus
solfataricus) 		PF00571
(CBS) 		4 GLY A 119
VAL A 118
ILE A   3
PHE A 126
 None
 0.89A 4fglC-3ddjA:
undetectable		 4fglC-3ddjA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli) 		PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C) 		4 GLY B 271
VAL B 272
PHE B 246
ILE B 251
 None
None
SF4  B 803 (-4.8A)
None
 0.92A 4fglC-3egwB:
undetectable		 4fglC-3egwB:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		4 ASN A 246
GLY A 279
VAL A 278
PHE A 357
 None
 0.88A 4fglC-3eqnA:
undetectable		 4fglC-3eqnA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214

(Homo sapiens) 		PF12894
(ANAPC4_WD40) 		4 GLY A 210
VAL A 209
ILE A 229
PHE A 287
 None
 0.87A 4fglC-3fhcA:
undetectable		 4fglC-3fhcA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hig AMILORIDE-SENSITIVE
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 GLY A 524
PHE A 701
ILE A 346
PHE A 702
 None
 0.89A 4fglC-3higA:
undetectable		 4fglC-3higA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
anthracis) 		PF00156
(Pribosyltran) 		4 GLY A  40
VAL A  98
PHE A 115
ILE A  95
 None
 0.92A 4fglC-3hvuA:
3.5		 4fglC-3hvuA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE

(Clostridium
acetobutylicum) 		PF00730
(HhH-GPD)
PF07934
(OGG_N) 		5 GLY A  45
VAL A  51
PHE A  79
ILE A  63
PHE A  21
 None
EDO  A 291 (-4.1A)
None
None
None
 1.15A 4fglC-3i0wA:
undetectable		 4fglC-3i0wA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuz PUTATIVE GLYOXALASE
SUPERFAMILY PROTEIN

(Cupriavidus
pinatubonensis) 		PF07063
(DUF1338) 		4 GLY A  63
PHE A  53
ILE A  56
PHE A  79
 None
 0.82A 4fglC-3iuzA:
undetectable		 4fglC-3iuzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4w UNCHARACTERIZED
PROTEIN BB4693

(Bordetella
bronchiseptica) 		PF04909
(Amidohydro_2) 		4 ASN A 121
GLY A  66
VAL A  65
ILE A  20
 None
 0.83A 4fglC-3k4wA:
undetectable		 4fglC-3k4wA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksk TYPE-2 RESTRICTION
ENZYME PVUII

(Proteus hauseri) 		PF09225
(Endonuc-PvuII) 		4 ASN A 233
GLY A 266
GLN A  20
ILE A  31
 None
 0.80A 4fglC-3kskA:
undetectable		 4fglC-3kskA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kws PUTATIVE SUGAR
ISOMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		4 ASN A 215
GLY A 217
VAL A 218
ILE A 135
 None
 0.89A 4fglC-3kwsA:
undetectable		 4fglC-3kwsA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxp PRETHROMBIN-1

(Homo sapiens) 		PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light) 		4 ASN A 221
GLY A 224
PHE A 280
PHE A 281
 None
 0.85A 4fglC-3nxpA:
undetectable		 4fglC-3nxpA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqb OXIDOREDUCTASE

(Bradyrhizobium
diazoefficiens) 		PF01408
(GFO_IDH_MocA) 		4 GLY A  13
VAL A  14
PHE A  87
ILE A  10
 None
 0.86A 4fglC-3oqbA:
3.0		 4fglC-3oqbA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Candida
albicans) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 ASN A 125
GLY A 338
VAL A 337
PHE A 316
 None
 0.73A 4fglC-3qo7A:
undetectable		 4fglC-3qo7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Legionella
pneumophila) 		PF00478
(IMPDH) 		4 ASN A 148
GLY A 169
PHE A  10
ILE A 208
 None
 0.90A 4fglC-3r2gA:
undetectable		 4fglC-3r2gA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s69 THROMBIN-LIKE ENZYME
DEFIBRASE

(Gloydius
saxatilis) 		PF00089
(Trypsin) 		4 GLY A  43
VAL A  31
PHE A 205
ILE A  46
 None
 0.69A 4fglC-3s69A:
undetectable		 4fglC-3s69A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 ASN A 542
GLY A 541
ILE A 517
PHE A 568
 None
 0.81A 4fglC-3syjA:
undetectable		 4fglC-3syjA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc8 LEUCINE
AMINOPEPTIDASE

(Parabacteroides
distasonis) 		PF04389
(Peptidase_M28) 		4 GLY A 151
VAL A 152
PHE A  42
ILE A 158
 None
 0.91A 4fglC-3tc8A:
3.1		 4fglC-3tc8A:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3te7 RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE]

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		7 ASN A  66
GLY A  68
VAL A  69
GLN A 122
PHE A 126
ILE A 128
PHE A 178
 None
TE7  A   1 ( 4.1A)
None
TE7  A   1 ( 4.3A)
TE7  A   1 (-4.3A)
None
TE7  A   1 (-3.6A)
 0.63A 4fglC-3te7A:
38.5		 4fglC-3te7A:
98.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txv PROBABLE TAGATOSE
6-PHOSPHATE KINASE

(Sinorhizobium
meliloti) 		PF08013
(Tagatose_6_P_K) 		4 GLY A 289
VAL A 288
ILE A  50
PHE A  71
 None
 0.83A 4fglC-3txvA:
undetectable		 4fglC-3txvA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4v INTEGRIN BETA-7

(Homo sapiens) 		PF00362
(Integrin_beta) 		4 GLY B 241
PHE B 267
ILE B 246
PHE B 327
 None
 0.70A 4fglC-3v4vB:
2.6		 4fglC-3v4vB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLY A1263
GLN A1352
PHE A1280
ILE A1276
 None
 0.79A 4fglC-3va7A:
undetectable		 4fglC-3va7A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo) 		PF00082
(Peptidase_S8) 		4 GLY A 137
VAL A 136
ILE A 178
PHE A 172
 None
 0.85A 4fglC-3vtaA:
2.5		 4fglC-3vtaA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF01554
(MatE) 		4 ASN A 153
PHE A  63
ILE A  66
PHE A  59
 OLC  A 505 ( 4.2A)
None
None
None
 0.91A 4fglC-3wbnA:
undetectable		 4fglC-3wbnA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 GLY A 563
VAL A 562
ILE A 585
PHE A 621
 None
 0.87A 4fglC-3wpeA:
undetectable		 4fglC-3wpeA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdp NUCLEOCAPSID PROTEIN

(Influenza A
virus) 		PF00506
(Flu_NP) 		5 GLY A 187
VAL A 186
GLN A 168
PHE A 338
PHE A 488
 None
 1.49A 4fglC-3zdpA:
undetectable		 4fglC-3zdpA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PDX2 PROTEIN

(Plasmodium
falciparum) 		PF01174
(SNO) 		4 GLY G   7
VAL G   8
PHE G  75
ILE G  83
 None
 0.87A 4fglC-4adsG:
4.2		 4fglC-4adsG:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgv MALATE DEHYDROGENASE

(Picrophilus
torridus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A 109
VAL A 108
PHE A 320
ILE A 102
 None
 0.91A 4fglC-4bgvA:
5.1		 4fglC-4bgvA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE

(Trypanosoma
brucei) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A 146
VAL A 145
PHE A  24
ILE A  21
PHE A 383
 None
 1.16A 4fglC-4bi9A:
undetectable		 4fglC-4bi9A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		4 GLY B 221
PHE B 248
ILE B 226
PHE B 308
 None
 0.76A 4fglC-4cakB:
2.3		 4fglC-4cakB:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius halys) 		PF00089
(Trypsin) 		4 GLY A  44
VAL A  31
PHE A 209
ILE A  47
 None
 0.79A 4fglC-4e7nA:
undetectable		 4fglC-4e7nA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fuu LEUCINE
AMINOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF04389
(Peptidase_M28) 		4 GLY A 153
VAL A 154
PHE A  44
ILE A 160
 None
 0.86A 4fglC-4fuuA:
3.0		 4fglC-4fuuA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1k TRIOSEPHOSPHATE
ISOMERASE

(Burkholderia
thailandensis) 		PF00121
(TIM) 		4 GLY A  43
VAL A  44
ILE A 233
PHE A 223
 None
 0.83A 4fglC-4g1kA:
undetectable		 4fglC-4g1kA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Acinetobacter
sp. ADP1) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 ASN A 205
GLY A 208
VAL A 209
ILE A  94
 None
 0.77A 4fglC-4gtnA:
undetectable		 4fglC-4gtnA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j05 PHOSPHATE
TRANSPORTER

(Serendipita
indica) 		PF00083
(Sugar_tr) 		4 GLY A  41
VAL A  40
ILE A 173
PHE A 435
 None
 0.89A 4fglC-4j05A:
undetectable		 4fglC-4j05A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Flavobacterium
johnsoniae) 		PF01884
(PcrB) 		4 GLY A 208
VAL A 207
ILE A 217
PHE A 240
 1GP  A 301 (-3.4A)
None
None
None
 0.82A 4fglC-4jejA:
undetectable		 4fglC-4jejA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo8 M157

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 GLY A 170
GLN A 102
PHE A  98
ILE A 101
 None
 0.74A 4fglC-4jo8A:
undetectable		 4fglC-4jo8A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqs HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF06283
(ThuA) 		4 ASN A  88
GLY A 115
VAL A  89
ILE A 228
 None
 0.92A 4fglC-4jqsA:
4.4		 4fglC-4jqsA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqs HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF06283
(ThuA) 		4 GLY A 115
VAL A  89
PHE A 106
PHE A 134
 None
 0.88A 4fglC-4jqsA:
4.4		 4fglC-4jqsA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7c BLA G 4 ALLERGEN
VARIANT 1

(Blattella
germanica) 		PF03973
(Triabin) 		4 GLY A 111
PHE A  81
ILE A  83
PHE A  49
 None
 0.87A 4fglC-4n7cA:
undetectable		 4fglC-4n7cA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2

(Homo sapiens;
Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF17205
(PSI_integrin) 		4 GLY A 412
PHE B 247
ILE A 435
PHE B 245
 None
 0.77A 4fglC-4nenA:
undetectable		 4fglC-4nenA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4or8 MEMBRANE-ASSOCIATED
PROTEIN VP24

(Marburg
marburgvirus) 		PF06389
(Filo_VP24) 		4 GLY A 196
VAL A 193
ILE A 190
PHE A 160
 None
 0.89A 4fglC-4or8A:
undetectable		 4fglC-4or8A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A 347
VAL A 348
PHE A 410
ILE A 354
 None
 0.83A 4fglC-4qavA:
undetectable		 4fglC-4qavA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfw ACYL-COA
THIOESTERASE II

(Yersinia pestis) 		PF13622
(4HBT_3) 		5 GLY A  37
VAL A  39
PHE A  60
ILE A  44
PHE A 235
 None
 1.42A 4fglC-4qfwA:
undetectable		 4fglC-4qfwA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv3 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE

(Staphylococcus
aureus) 		PF00388
(PI-PLC-X) 		4 GLY A  60
PHE A  64
ILE A 108
PHE A  92
 None
 0.86A 4fglC-4rv3A:
undetectable		 4fglC-4rv3A:
22.44