SIMILAR PATTERNS OF AMINO ACIDS FOR 4FGL_D_CLQD303

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azz COLLAGENASE

(Leptuca
pugilator) 		PF00089
(Trypsin) 		5 ASN A  25
GLY A  69
GLN A  80
ILE A  73
PHE A  34
 None
 1.49A 4fglC-1azzA:
undetectable		 4fglC-1azzA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri) 		PF00089
(Trypsin) 		4 GLY A  44
VAL A  31
PHE A 209
ILE A  47
 None
 0.66A 4fglC-1bqyA:
undetectable		 4fglC-1bqyA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy2 COLLAGEN ALPHA1(XV)
CHAIN

(Mus musculus) 		PF06482
(Endostatin) 		4 ASN A 196
GLY A 199
VAL A 200
PHE A 139
 None
 0.75A 4fglC-1dy2A:
undetectable		 4fglC-1dy2A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Leishmania
mexicana) 		PF00274
(Glycolytic) 		4 VAL A 112
PHE A  78
ILE A  82
PHE A 337
 None
 0.77A 4fglC-1epxA:
0.5		 4fglC-1epxA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00274
(Glycolytic) 		4 VAL A 112
PHE A  78
ILE A  82
PHE A 337
 None
 0.77A 4fglC-1f2jA:
undetectable		 4fglC-1f2jA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f7u ARGINYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 GLY A 207
PHE A 269
ILE A 265
PHE A 196
 None
 0.92A 4fglC-1f7uA:
4.4		 4fglC-1f7uA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hus RIBOSOMAL PROTEIN S7

(Geobacillus
stearothermophilus) 		PF00177
(Ribosomal_S7) 		5 GLY A  99
VAL A  68
PHE A  61
ILE A 123
PHE A  46
 None
 1.48A 4fglC-1husA:
undetectable		 4fglC-1husA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ASN A  49
GLY A  51
PHE A  79
ILE A  83
 None
 0.91A 4fglC-1i2dA:
1.9		 4fglC-1i2dA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j93 UROPORPHYRINOGEN
DECARBOXYLASE

(Nicotiana
tabacum) 		PF01208
(URO-D) 		4 GLY A 164
VAL A 103
ILE A  92
PHE A 190
 None
 0.87A 4fglC-1j93A:
undetectable		 4fglC-1j93A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		4 ASN A 646
VAL A  27
ILE A  30
PHE A 687
 None
 0.88A 4fglC-1kehA:
undetectable		 4fglC-1kehA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kj9 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE 2

(Escherichia
coli) 		PF02222
(ATP-grasp) 		4 GLY A 196
VAL A 197
ILE A 168
PHE A 141
 EDO  A 402 ( 3.2A)
ATP  A   1 (-3.9A)
None
None
 0.77A 4fglC-1kj9A:
3.7		 4fglC-1kj9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		5 ASN A 634
GLY A 594
VAL A 595
ILE A 606
PHE A 517
 None
 1.50A 4fglC-1lzxA:
undetectable		 4fglC-1lzxA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE

(Klebsiella sp.
LX3) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLY A 593
VAL A 594
ILE A 395
PHE A 551
 None
 0.92A 4fglC-1m53A:
undetectable		 4fglC-1m53A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1op2 VENOM SERINE
PROTEINASE

(Deinagkistrodon
acutus) 		PF00089
(Trypsin) 		4 GLY A  44
VAL A  31
PHE A 209
ILE A  47
 None
 0.71A 4fglC-1op2A:
undetectable		 4fglC-1op2A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orf GRANZYME A

(Homo sapiens) 		PF00089
(Trypsin) 		4 GLY A  44
VAL A  31
PHE A 209
ILE A  47
 None
 0.79A 4fglC-1orfA:
undetectable		 4fglC-1orfA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg5 ASPARTATE
CARBAMOYLTRANSFERASE

(Sulfolobus
acidocaldarius) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 GLY A 285
VAL A 286
ILE A 292
PHE A  10
 None
 0.81A 4fglC-1pg5A:
3.9		 4fglC-1pg5A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Homo sapiens) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 ASN A 463
GLY A 459
ILE A 536
PHE A 542
 None
 0.84A 4fglC-1pl0A:
undetectable		 4fglC-1pl0A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv9 XAA-PRO DIPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 GLY A  40
VAL A  53
PHE A  21
ILE A  78
PHE A 102
 None
 1.44A 4fglC-1pv9A:
undetectable		 4fglC-1pv9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxz PROTEIN (CU-ZN
SUPEROXIDE
DISMUTASE)

(Bos taurus) 		PF00080
(Sod_Cu) 		4 GLY A 145
VAL A 146
PHE A  20
ILE A 110
 None
 0.92A 4fglC-1sxzA:
undetectable		 4fglC-1sxzA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE

(Mycobacterium
bovis) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		4 GLY A 147
VAL A 146
ILE A 130
PHE A  67
 None
 0.92A 4fglC-1tdtA:
undetectable		 4fglC-1tdtA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF14519
(Macro_2) 		4 GLY A  79
PHE A 106
ILE A 143
PHE A 102
 APR  A 285 (-3.6A)
None
None
None
 0.79A 4fglC-1txzA:
undetectable		 4fglC-1txzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF14519
(Macro_2) 		4 VAL A 146
PHE A 106
ILE A 143
PHE A 102
 None
 0.76A 4fglC-1txzA:
undetectable		 4fglC-1txzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 GLY A 106
PHE A 201
ILE A 162
PHE A 129
 None
 0.87A 4fglC-1ty2A:
undetectable		 4fglC-1ty2A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tye INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 GLY B 221
PHE B 248
ILE B 226
PHE B 308
 None
 0.74A 4fglC-1tyeB:
4.8		 4fglC-1tyeB:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 2

(Bos taurus) 		PF00022
(Actin) 		4 GLY B 255
VAL B 241
ILE B 252
PHE B 204
 None
 0.92A 4fglC-1u2vB:
undetectable		 4fglC-1u2vB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		4 GLY A 132
VAL A 133
PHE A 144
ILE A 111
 None
 0.83A 4fglC-1vclA:
undetectable		 4fglC-1vclA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmo VITELLINE MEMBRANE
OUTER LAYER PROTEIN
I

(Gallus gallus) 		PF03762
(VOMI) 		4 GLY A  14
PHE A  87
ILE A 106
PHE A 159
 None
 0.90A 4fglC-1vmoA:
undetectable		 4fglC-1vmoA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Thermotoga
maritima) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ASN A 273
GLY A 294
PHE A   7
ILE A 337
 None
 0.88A 4fglC-1vrdA:
undetectable		 4fglC-1vrdA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A

(Pyrococcus
horikoshii) 		PF00117
(GATase) 		4 VAL A  64
PHE A  89
ILE A  85
PHE A 139
 None
 0.81A 4fglC-1wl8A:
4.9		 4fglC-1wl8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 GLY A 735
VAL A 795
PHE A 746
ILE A 760
 None
NAG  A5001 (-4.7A)
None
None
 0.85A 4fglC-1xc6A:
undetectable		 4fglC-1xc6A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc4 RAS-RELATED PROTEIN
RAL-A

(Homo sapiens) 		PF00071
(Ras) 		4 GLY A  21
VAL A  92
PHE A  83
ILE A  18
 None
 0.80A 4fglC-1zc4A:
4.7		 4fglC-1zc4A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00155
(Aminotran_1_2) 		4 GLY A 408
VAL A 407
PHE A 350
PHE A 352
 None
 0.74A 4fglC-2ay9A:
3.5		 4fglC-2ay9A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiq PUTATIVE TAGATOSE
6-PHOSPHATE KINASE 1

(Escherichia
coli) 		PF08013
(Tagatose_6_P_K) 		4 GLY A 281
VAL A 280
ILE A  43
PHE A  64
 None
 0.88A 4fglC-2fiqA:
undetectable		 4fglC-2fiqA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkk BASEPLATE STRUCTURAL
PROTEIN GP10

(Escherichia
virus T4) 		no annotation 4 ASN A 502
GLY A 517
PHE A 481
ILE A 428
 None
 0.80A 4fglC-2fkkA:
undetectable		 4fglC-2fkkA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3a ACETYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13673
(Acetyltransf_10) 		4 ASN A  38
GLY A  54
VAL A  53
GLN A  64
 None
 0.81A 4fglC-2g3aA:
undetectable		 4fglC-2g3aA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Aquifex
aeolicus) 		PF00308
(Bac_DnaA)
PF08299
(Bac_DnaA_C) 		4 ASN A 113
PHE A 195
ILE A 198
PHE A 151
 None
 0.91A 4fglC-2hcbA:
undetectable		 4fglC-2hcbA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Aquifex
aeolicus) 		PF00308
(Bac_DnaA)
PF08299
(Bac_DnaA_C) 		4 GLY A 234
PHE A 199
ILE A 209
PHE A 195
 None
 0.71A 4fglC-2hcbA:
undetectable		 4fglC-2hcbA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU

(Streptococcus
pneumoniae) 		PF01895
(PhoU) 		4 VAL A 205
PHE A 137
ILE A 200
PHE A  16
 None
 0.90A 4fglC-2i0mA:
undetectable		 4fglC-2i0mA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5k UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01704
(UDPGP) 		4 ASN A 317
GLY A 365
PHE A 220
ILE A 323
 None
 0.92A 4fglC-2i5kA:
undetectable		 4fglC-2i5kA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu5 HTH-TYPE DHAKLM
OPERON
TRANSCRIPTIONAL
ACTIVATOR DHAS

(Lactococcus
lactis) 		PF00440
(TetR_N) 		4 ASN A  67
GLN A 110
PHE A 106
ILE A 109
 None
 0.89A 4fglC-2iu5A:
undetectable		 4fglC-2iu5A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8s AGR_C_984P

(Agrobacterium
fabrum) 		PF06748
(DUF1217) 		4 ASN A 193
GLY A 195
VAL A 196
ILE A 271
 None
 0.90A 4fglC-2o8sA:
undetectable		 4fglC-2o8sA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odr PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanococcus
maripaludis) 		PF01409
(tRNA-synt_2d) 		4 GLY B 190
GLN B  81
PHE B  82
ILE B  78
 None
 0.81A 4fglC-2odrB:
undetectable		 4fglC-2odrB:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pae DTDP-6-DEOXY-3,4-KET
O-HEXULOSE ISOMERASE

(Aneurinibacillus
thermoaerophilus) 		PF05523
(FdtA) 		4 ASN A  49
GLY A  47
PHE A 100
ILE A  37
 None
 0.91A 4fglC-2paeA:
undetectable		 4fglC-2paeA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 ASN A 362
GLY A 338
VAL A 339
ILE A 248
 None
 0.86A 4fglC-2uvfA:
undetectable		 4fglC-2uvfA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w20 SIALIDASE A

(Streptococcus
pneumoniae) 		PF13088
(BNR_2) 		4 GLY A 567
VAL A 568
PHE A 436
ILE A 416
 None
 0.90A 4fglC-2w20A:
undetectable		 4fglC-2w20A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3y VIRULENCE FACTOR

(Pectobacterium
carotovorum) 		no annotation 4 GLY A 152
PHE A 198
ILE A 205
PHE A 219
 PLM  A1278 ( 4.2A)
None
None
PLM  A1278 ( 3.7A)
 0.88A 4fglC-2w3yA:
undetectable		 4fglC-2w3yA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03198
(Glyco_hydro_72)
PF07983
(X8) 		4 GLY A 212
VAL A 211
PHE A  43
ILE A  38
 None
 0.92A 4fglC-2w61A:
undetectable		 4fglC-2w61A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wb7 PT26-6P

(Thermococcus
sp. 26-2) 		no annotation 4 GLY A 475
PHE A 483
ILE A 433
PHE A 453
 None
 0.84A 4fglC-2wb7A:
undetectable		 4fglC-2wb7A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahy BETA-GLUCOSIDASE

(Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		5 GLY A 201
VAL A 286
PHE A 163
ILE A 196
PHE A 118
 None
 1.50A 4fglC-3ahyA:
undetectable		 4fglC-3ahyA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anx SPERMIDINE SYNTHASE

(Thermus
thermophilus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 VAL A  53
PHE A 234
ILE A 227
PHE A 236
 None
 0.85A 4fglC-3anxA:
2.9		 4fglC-3anxA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 GLY A 819
VAL A 818
GLN A 817
ILE A 813
PHE A 787
 None
None
WAN  A 901 (-3.1A)
WAN  A 901 ( 4.3A)
None
 1.46A 4fglC-3bjcA:
undetectable		 4fglC-3bjcA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A  82
VAL A  74
ILE A  71
PHE A 374
 None
 0.89A 4fglC-3bjsA:
undetectable		 4fglC-3bjsA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce1 SUPEROXIDE DISMUTASE
[CU-ZN]

(Naganishia
liquefaciens) 		PF00080
(Sod_Cu) 		4 GLY A 151
VAL A 152
PHE A  23
ILE A 116
 None
 0.88A 4fglC-3ce1A:
undetectable		 4fglC-3ce1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chl ALPHA-14 GIARDIN

(Giardia
intestinalis) 		PF00191
(Annexin) 		4 GLY A 301
VAL A 302
ILE A 307
PHE A 255
 None
 0.89A 4fglC-3chlA:
undetectable		 4fglC-3chlA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Enterococcus
faecalis) 		PF13377
(Peripla_BP_3) 		4 GLY A  63
VAL A  64
PHE A 127
ILE A 134
 None
 0.84A 4fglC-3cs3A:
5.3		 4fglC-3cs3A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddj CBS
DOMAIN-CONTAINING
PROTEIN

(Sulfolobus
solfataricus) 		PF00571
(CBS) 		4 GLY A 119
VAL A 118
ILE A   3
PHE A 126
 None
 0.89A 4fglC-3ddjA:
undetectable		 4fglC-3ddjA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli) 		PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C) 		4 GLY B 271
VAL B 272
PHE B 246
ILE B 251
 None
None
SF4  B 803 (-4.8A)
None
 0.92A 4fglC-3egwB:
undetectable		 4fglC-3egwB:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		4 ASN A 246
GLY A 279
VAL A 278
PHE A 357
 None
 0.88A 4fglC-3eqnA:
undetectable		 4fglC-3eqnA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214

(Homo sapiens) 		PF12894
(ANAPC4_WD40) 		4 GLY A 210
VAL A 209
ILE A 229
PHE A 287
 None
 0.87A 4fglC-3fhcA:
undetectable		 4fglC-3fhcA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hig AMILORIDE-SENSITIVE
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 GLY A 524
PHE A 701
ILE A 346
PHE A 702
 None
 0.89A 4fglC-3higA:
undetectable		 4fglC-3higA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
anthracis) 		PF00156
(Pribosyltran) 		4 GLY A  40
VAL A  98
PHE A 115
ILE A  95
 None
 0.92A 4fglC-3hvuA:
3.5		 4fglC-3hvuA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE

(Clostridium
acetobutylicum) 		PF00730
(HhH-GPD)
PF07934
(OGG_N) 		5 GLY A  45
VAL A  51
PHE A  79
ILE A  63
PHE A  21
 None
EDO  A 291 (-4.1A)
None
None
None
 1.15A 4fglC-3i0wA:
undetectable		 4fglC-3i0wA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuz PUTATIVE GLYOXALASE
SUPERFAMILY PROTEIN

(Cupriavidus
pinatubonensis) 		PF07063
(DUF1338) 		4 GLY A  63
PHE A  53
ILE A  56
PHE A  79
 None
 0.82A 4fglC-3iuzA:
undetectable		 4fglC-3iuzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4w UNCHARACTERIZED
PROTEIN BB4693

(Bordetella
bronchiseptica) 		PF04909
(Amidohydro_2) 		4 ASN A 121
GLY A  66
VAL A  65
ILE A  20
 None
 0.83A 4fglC-3k4wA:
undetectable		 4fglC-3k4wA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksk TYPE-2 RESTRICTION
ENZYME PVUII

(Proteus hauseri) 		PF09225
(Endonuc-PvuII) 		4 ASN A 233
GLY A 266
GLN A  20
ILE A  31
 None
 0.80A 4fglC-3kskA:
undetectable		 4fglC-3kskA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kws PUTATIVE SUGAR
ISOMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		4 ASN A 215
GLY A 217
VAL A 218
ILE A 135
 None
 0.89A 4fglC-3kwsA:
undetectable		 4fglC-3kwsA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxp PRETHROMBIN-1

(Homo sapiens) 		PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light) 		4 ASN A 221
GLY A 224
PHE A 280
PHE A 281
 None
 0.85A 4fglC-3nxpA:
undetectable		 4fglC-3nxpA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqb OXIDOREDUCTASE

(Bradyrhizobium
diazoefficiens) 		PF01408
(GFO_IDH_MocA) 		4 GLY A  13
VAL A  14
PHE A  87
ILE A  10
 None
 0.86A 4fglC-3oqbA:
3.0		 4fglC-3oqbA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Candida
albicans) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 ASN A 125
GLY A 338
VAL A 337
PHE A 316
 None
 0.73A 4fglC-3qo7A:
undetectable		 4fglC-3qo7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Legionella
pneumophila) 		PF00478
(IMPDH) 		4 ASN A 148
GLY A 169
PHE A  10
ILE A 208
 None
 0.90A 4fglC-3r2gA:
undetectable		 4fglC-3r2gA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s69 THROMBIN-LIKE ENZYME
DEFIBRASE

(Gloydius
saxatilis) 		PF00089
(Trypsin) 		4 GLY A  43
VAL A  31
PHE A 205
ILE A  46
 None
 0.69A 4fglC-3s69A:
undetectable		 4fglC-3s69A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 ASN A 542
GLY A 541
ILE A 517
PHE A 568
 None
 0.81A 4fglC-3syjA:
undetectable		 4fglC-3syjA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc8 LEUCINE
AMINOPEPTIDASE

(Parabacteroides
distasonis) 		PF04389
(Peptidase_M28) 		4 GLY A 151
VAL A 152
PHE A  42
ILE A 158
 None
 0.91A 4fglC-3tc8A:
3.1		 4fglC-3tc8A:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3te7 RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE]

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		7 ASN A  66
GLY A  68
VAL A  69
GLN A 122
PHE A 126
ILE A 128
PHE A 178
 None
TE7  A   1 ( 4.1A)
None
TE7  A   1 ( 4.3A)
TE7  A   1 (-4.3A)
None
TE7  A   1 (-3.6A)
 0.63A 4fglC-3te7A:
38.5		 4fglC-3te7A:
98.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txv PROBABLE TAGATOSE
6-PHOSPHATE KINASE

(Sinorhizobium
meliloti) 		PF08013
(Tagatose_6_P_K) 		4 GLY A 289
VAL A 288
ILE A  50
PHE A  71
 None
 0.83A 4fglC-3txvA:
undetectable		 4fglC-3txvA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4v INTEGRIN BETA-7

(Homo sapiens) 		PF00362
(Integrin_beta) 		4 GLY B 241
PHE B 267
ILE B 246
PHE B 327
 None
 0.70A 4fglC-3v4vB:
2.6		 4fglC-3v4vB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLY A1263
GLN A1352
PHE A1280
ILE A1276
 None
 0.79A 4fglC-3va7A:
undetectable		 4fglC-3va7A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo) 		PF00082
(Peptidase_S8) 		4 GLY A 137
VAL A 136
ILE A 178
PHE A 172
 None
 0.85A 4fglC-3vtaA:
2.5		 4fglC-3vtaA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF01554
(MatE) 		4 ASN A 153
PHE A  63
ILE A  66
PHE A  59
 OLC  A 505 ( 4.2A)
None
None
None
 0.91A 4fglC-3wbnA:
undetectable		 4fglC-3wbnA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 GLY A 563
VAL A 562
ILE A 585
PHE A 621
 None
 0.87A 4fglC-3wpeA:
undetectable		 4fglC-3wpeA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdp NUCLEOCAPSID PROTEIN

(Influenza A
virus) 		PF00506
(Flu_NP) 		5 GLY A 187
VAL A 186
GLN A 168
PHE A 338
PHE A 488
 None
 1.49A 4fglC-3zdpA:
undetectable		 4fglC-3zdpA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PDX2 PROTEIN

(Plasmodium
falciparum) 		PF01174
(SNO) 		4 GLY G   7
VAL G   8
PHE G  75
ILE G  83
 None
 0.87A 4fglC-4adsG:
4.2		 4fglC-4adsG:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgv MALATE DEHYDROGENASE

(Picrophilus
torridus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A 109
VAL A 108
PHE A 320
ILE A 102
 None
 0.91A 4fglC-4bgvA:
5.1		 4fglC-4bgvA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE

(Trypanosoma
brucei) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A 146
VAL A 145
PHE A  24
ILE A  21
PHE A 383
 None
 1.16A 4fglC-4bi9A:
undetectable		 4fglC-4bi9A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		4 GLY B 221
PHE B 248
ILE B 226
PHE B 308
 None
 0.76A 4fglC-4cakB:
2.3		 4fglC-4cakB:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius halys) 		PF00089
(Trypsin) 		4 GLY A  44
VAL A  31
PHE A 209
ILE A  47
 None
 0.79A 4fglC-4e7nA:
undetectable		 4fglC-4e7nA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fuu LEUCINE
AMINOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF04389
(Peptidase_M28) 		4 GLY A 153
VAL A 154
PHE A  44
ILE A 160
 None
 0.86A 4fglC-4fuuA:
3.0		 4fglC-4fuuA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1k TRIOSEPHOSPHATE
ISOMERASE

(Burkholderia
thailandensis) 		PF00121
(TIM) 		4 GLY A  43
VAL A  44
ILE A 233
PHE A 223
 None
 0.83A 4fglC-4g1kA:
undetectable		 4fglC-4g1kA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Acinetobacter
sp. ADP1) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 ASN A 205
GLY A 208
VAL A 209
ILE A  94
 None
 0.77A 4fglC-4gtnA:
undetectable		 4fglC-4gtnA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j05 PHOSPHATE
TRANSPORTER

(Serendipita
indica) 		PF00083
(Sugar_tr) 		4 GLY A  41
VAL A  40
ILE A 173
PHE A 435
 None
 0.89A 4fglC-4j05A:
undetectable		 4fglC-4j05A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Flavobacterium
johnsoniae) 		PF01884
(PcrB) 		4 GLY A 208
VAL A 207
ILE A 217
PHE A 240
 1GP  A 301 (-3.4A)
None
None
None
 0.82A 4fglC-4jejA:
undetectable		 4fglC-4jejA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo8 M157

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 GLY A 170
GLN A 102
PHE A  98
ILE A 101
 None
 0.74A 4fglC-4jo8A:
undetectable		 4fglC-4jo8A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqs HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF06283
(ThuA) 		4 ASN A  88
GLY A 115
VAL A  89
ILE A 228
 None
 0.92A 4fglC-4jqsA:
4.4		 4fglC-4jqsA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqs HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF06283
(ThuA) 		4 GLY A 115
VAL A  89
PHE A 106
PHE A 134
 None
 0.88A 4fglC-4jqsA:
4.4		 4fglC-4jqsA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7c BLA G 4 ALLERGEN
VARIANT 1

(Blattella
germanica) 		PF03973
(Triabin) 		4 GLY A 111
PHE A  81
ILE A  83
PHE A  49
 None
 0.87A 4fglC-4n7cA:
undetectable		 4fglC-4n7cA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2

(Homo sapiens;
Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF17205
(PSI_integrin) 		4 GLY A 412
PHE B 247
ILE A 435
PHE B 245
 None
 0.77A 4fglC-4nenA:
undetectable		 4fglC-4nenA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4or8 MEMBRANE-ASSOCIATED
PROTEIN VP24

(Marburg
marburgvirus) 		PF06389
(Filo_VP24) 		4 GLY A 196
VAL A 193
ILE A 190
PHE A 160
 None
 0.89A 4fglC-4or8A:
undetectable		 4fglC-4or8A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A 347
VAL A 348
PHE A 410
ILE A 354
 None
 0.83A 4fglC-4qavA:
undetectable		 4fglC-4qavA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfw ACYL-COA
THIOESTERASE II

(Yersinia pestis) 		PF13622
(4HBT_3) 		5 GLY A  37
VAL A  39
PHE A  60
ILE A  44
PHE A 235
 None
 1.42A 4fglC-4qfwA:
undetectable		 4fglC-4qfwA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv3 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE

(Staphylococcus
aureus) 		PF00388
(PI-PLC-X) 		4 GLY A  60
PHE A  64
ILE A 108
PHE A  92
 None
 0.86A 4fglC-4rv3A:
undetectable		 4fglC-4rv3A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpy SERINE
CARBOXYPEPTIDASE

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		4 GLY A 197
GLY A 196
GLU A 198
ILE A 258
 None
 0.79A 4fglD-1cpyA:
2.4		 4fglD-1cpyA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e25 EXTENDED-SPECTRUM
BETA-LACTAMASE PER-1

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		4 GLY A 185
MET A  68
GLU A 188
ILE A 189
 None
 0.96A 4fglD-1e25A:
undetectable		 4fglD-1e25A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ez4 LACTATE
DEHYDROGENASE

(Lactobacillus
pentosus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A 295
GLY A 294
ASN A 267
ILE A 132
 None
 0.93A 4fglD-1ez4A:
4.3		 4fglD-1ez4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		4 GLY A 508
GLY A 507
ASN A 505
GLU A 207
 None
 0.75A 4fglD-1fehA:
undetectable		 4fglD-1fehA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i41 CYSTATHIONINE
GAMMA-SYNTHASE

(Nicotiana
tabacum) 		PF01053
(Cys_Met_Meta_PP) 		4 GLY A 391
GLY A 390
GLU A 393
ILE A 395
 None
 0.64A 4fglD-1i41A:
3.1		 4fglD-1i41A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 GLY A 276
GLY A 275
MET A 171
ILE A 450
 None
 0.90A 4fglD-1lamA:
undetectable		 4fglD-1lamA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1md6 INTERLEUKIN 1
FAMILY, MEMBER 5
(DELTA)

(Mus musculus) 		PF00340
(IL1) 		4 GLY A  62
GLY A  63
ASN A  83
GLU A  40
 None
 0.90A 4fglD-1md6A:
undetectable		 4fglD-1md6A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Pseudomonas sp.
CF600) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		4 GLY A 324
GLY A 323
MET A 141
ILE A  93
 None
None
OXL  A3508 (-3.6A)
None
 0.99A 4fglD-1nvmA:
undetectable		 4fglD-1nvmA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1row MSP-DOMAIN PROTEIN
LIKE FAMILY MEMBER

(Caenorhabditis
elegans) 		PF00635
(Motile_Sperm) 		4 GLY A  27
GLY A  26
GLU A  29
ILE A  31
 None
 0.87A 4fglD-1rowA:
undetectable		 4fglD-1rowA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryo SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		4 GLY A 258
ASN A  55
GLU A 260
ILE A 263
 None
 0.87A 4fglD-1ryoA:
undetectable		 4fglD-1ryoA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9f PROTEIN 1D10

(Caenorhabditis
elegans) 		PF02815
(MIR) 		4 GLY A 187
GLY A 188
ASN A  36
ILE A 185
 None
 0.97A 4fglD-1t9fA:
undetectable		 4fglD-1t9fA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tii HEAT LABILE
ENTEROTOXIN TYPE IIB

(Escherichia
coli) 		PF01375
(Enterotoxin_a) 		4 GLY A 135
GLY A 136
GLU A 134
ILE A 133
 None
 0.98A 4fglD-1tiiA:
undetectable		 4fglD-1tiiA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 296
GLY A 295
GLU A 104
ILE A  89
 None
 0.83A 4fglD-1uufA:
4.3		 4fglD-1uufA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbl PECTATE LYASE 47

(Bacillus sp.
TS-47) 		PF00544
(Pec_lyase_C) 		4 GLY A 147
GLY A 148
MET A 127
GLU A 166
 None
 0.81A 4fglD-1vblA:
undetectable		 4fglD-1vblA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR

(Homo sapiens) 		PF13561
(adh_short_C2) 		4 GLY A  68
GLY A  67
ASN A 144
ILE A 103
 None
None
NAP  A1330 (-3.2A)
None
 0.74A 4fglD-1w8dA:
7.2		 4fglD-1w8dA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens) 		PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2) 		4 GLY A 382
ASN A 395
GLU A 208
ILE A 315
 None
 0.83A 4fglD-1w8oA:
undetectable		 4fglD-1w8oA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E

(Mus musculus) 		PF00755
(Carn_acyltransf) 		4 GLY A 322
MET A 128
ASN A 132
ILE A 320
 None
 0.93A 4fglD-1xl8A:
undetectable		 4fglD-1xl8A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b87 ZTAQ AFFIBODY
ANTI-ZTAQ AFFIBODY

(Staphylococcus
aureus;
Staphylococcus
aureus) 		PF02216
(B)
PF02216
(B) 		4 GLY B  14
GLY A  10
GLU B  15
ILE B  11
 None
 0.98A 4fglD-2b87B:
undetectable		 4fglD-2b87B:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cmh SPERMIDINE SYNTHASE

(Helicobacter
pylori) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A 190
GLY A 189
ASN A 259
ILE A 154
 None
 0.90A 4fglD-2cmhA:
undetectable		 4fglD-2cmhA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmm PROTEIN
DISULFIDE-ISOMERASE
A3

(Homo sapiens) 		PF00085
(Thioredoxin) 		4 GLY A 120
GLY A 121
GLU A 119
ILE A 104
 None
 0.93A 4fglD-2dmmA:
undetectable		 4fglD-2dmmA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE

(Pyrococcus
horikoshii) 		PF00390
(malic)
PF03949
(Malic_M) 		4 GLY A 101
GLY A 102
ASN A  64
ILE A 415
 None
 0.92A 4fglD-2dvmA:
3.6		 4fglD-2dvmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9q 11S GLOBULIN SUBUNIT
BETA

(Cucurbita
maxima) 		PF00190
(Cupin_1) 		4 GLY A 226
GLY A 227
GLU A 219
ILE A 224
 None
 0.99A 4fglD-2e9qA:
undetectable		 4fglD-2e9qA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eko HISTONE
ACETYLTRANSFERASE
HTATIP

(Homo sapiens) 		PF11717
(Tudor-knot) 		4 GLY A   8
GLY A   7
GLU A   9
ILE A  10
 None
 0.98A 4fglD-2ekoA:
undetectable		 4fglD-2ekoA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		4 GLY A 153
GLY A 131
MET A 421
ASN A 424
 None
GLN  A 501 ( 4.5A)
None
None
 0.86A 4fglD-2f2aA:
undetectable		 4fglD-2f2aA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe5 PRESYNAPTIC PROTEIN
SAP102

(Homo sapiens) 		PF00595
(PDZ) 		4 GLY A 263
GLY A 264
GLU A 262
ILE A 260
 None
 0.96A 4fglD-2fe5A:
undetectable		 4fglD-2fe5A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus sp.
GL1) 		PF07470
(Glyco_hydro_88) 		4 GLY A 226
GLY A 229
ASN A 233
ILE A 284
 None
 0.82A 4fglD-2fv0A:
undetectable		 4fglD-2fv0A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		4 GLY A 233
GLY A 234
ASN A 350
ILE A 266
 None
 0.87A 4fglD-2i7tA:
undetectable		 4fglD-2i7tA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k0d COLICIN-E7 IMMUNITY
PROTEIN

(Escherichia
coli) 		PF01320
(Colicin_Pyocin) 		5 GLY X  69
GLY X  70
ASN X  64
GLU X  78
ILE X  75
 None
 1.31A 4fglD-2k0dX:
undetectable		 4fglD-2k0dX:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE

(Homo sapiens) 		PF01053
(Cys_Met_Meta_PP) 		4 GLY A 202
ASN A 228
GLU A 170
ILE A 169
 None
 0.96A 4fglD-2nmpA:
2.3		 4fglD-2nmpA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o57 PUTATIVE SARCOSINE
DIMETHYLGLYCINE
METHYLTRANSFERASE

(Galdieria
sulphuraria) 		PF08241
(Methyltransf_11) 		4 GLY A 288
GLY A 287
MET A 189
ILE A 185
 None
 0.88A 4fglD-2o57A:
undetectable		 4fglD-2o57A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfk 6-PHOSPHOFRUCTOKINAS
E ISOZYME I

(Escherichia
coli) 		PF00365
(PFK) 		4 GLY A 185
GLY A 184
GLU A 187
ILE A 217
 None
 0.90A 4fglD-2pfkA:
4.7		 4fglD-2pfkA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL) 		4 GLY A 563
GLY A 566
ASN A 570
ILE A 728
 None
 0.94A 4fglD-2vdwA:
undetectable		 4fglD-2vdwA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhh CG3027-PA

(Drosophila
melanogaster) 		PF00795
(CN_hydrolase) 		4 GLY A 227
ASN A 187
GLU A 252
ILE A 253
 None
 0.95A 4fglD-2vhhA:
undetectable		 4fglD-2vhhA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3n CARBONIC ANHYDRASE 2

(Cryptococcus
neoformans) 		PF00484
(Pro_CA) 		4 GLY A 192
MET A 112
ASN A 108
GLU A 195
 None
 0.92A 4fglD-2w3nA:
undetectable		 4fglD-2w3nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzf GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		4 GLY A 223
GLY A 222
GLU A 215
ILE A 348
 None
 0.95A 4fglD-2wzfA:
undetectable		 4fglD-2wzfA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzg GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		4 GLY A 223
GLY A 222
GLU A 215
ILE A 348
 None
 0.95A 4fglD-2wzgA:
undetectable		 4fglD-2wzgA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3m HYPOTHETICAL PROTEIN
ORF239

(Pyrobaculum
spherical virus) 		no annotation 4 GLY A 121
GLY A 118
MET A 133
ILE A  77
 None
 0.98A 4fglD-2x3mA:
undetectable		 4fglD-2x3mA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzi EXTRACELLULAR
SIALIDASE/NEURAMINID
ASE, PUTATIVE

(Aspergillus
fumigatus) 		PF13088
(BNR_2) 		4 GLY A 353
MET A  43
ASN A  42
ILE A 391
 None
 0.98A 4fglD-2xziA:
undetectable		 4fglD-2xziA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLY A 661
GLY A 662
MET A 713
GLU A 718
 None
 0.66A 4fglD-3actA:
undetectable		 4fglD-3actA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Escherichia
coli) 		PF06751
(EutB) 		4 GLY A 241
GLY A 242
ASN A 148
ILE A 244
 None
 0.99A 4fglD-3anyA:
undetectable		 4fglD-3anyA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b57 LIN1889 PROTEIN

(Listeria
innocua) 		PF01966
(HD) 		4 GLY A  46
GLY A  45
GLU A 115
ILE A 118
 None
 0.93A 4fglD-3b57A:
undetectable		 4fglD-3b57A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf2 PUTATIVE LIPOPROTEIN

(Neisseria
meningitidis) 		PF04390
(LptE) 		4 GLY A  39
GLY A  40
GLU A  38
ILE A  37
 None
 0.93A 4fglD-3bf2A:
2.9		 4fglD-3bf2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		4 GLY A 281
GLY A 280
GLU A 110
ILE A 103
 None
 0.92A 4fglD-3bs8A:
undetectable		 4fglD-3bs8A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czm L-LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A 294
GLY A 297
MET A 159
ASN A 158
 None
 0.99A 4fglD-3czmA:
2.1		 4fglD-3czmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Methanosarcina
acetivorans) 		PF00005
(ABC_tran)
PF03459
(TOBE) 		5 GLY A  36
GLY A  38
ASN A  13
GLU A 153
ILE A 184
 None
 1.48A 4fglD-3d31A:
undetectable		 4fglD-3d31A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF01063
(Aminotran_4) 		4 GLY A 253
GLY A 254
GLU A 340
ILE A 341
 None
 0.94A 4fglD-3dtgA:
undetectable		 4fglD-3dtgA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flb RIFR

(Amycolatopsis
mediterranei) 		PF00975
(Thioesterase) 		4 GLY A  70
GLY A  71
GLU A 102
ILE A  99
 None
 0.86A 4fglD-3flbA:
3.1		 4fglD-3flbA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1v GLUCOKINASE

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 GLY X 229
GLY X 227
GLU X 290
ILE X 293
 GLC  X 500 ( 3.8A)
None
GLC  X 500 (-3.1A)
None
 0.86A 4fglD-3h1vX:
undetectable		 4fglD-3h1vX:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ics COENZYME A-DISULFIDE
REDUCTASE

(Bacillus
anthracis) 		PF00581
(Rhodanese)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A  14
GLY A  13
ASN A 306
ILE A 111
 None
FAD  A 555 (-3.5A)
COA  A 556 (-3.3A)
None
 0.94A 4fglD-3icsA:
undetectable		 4fglD-3icsA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipw HYDROLASE TATD
FAMILY PROTEIN

(Entamoeba
histolytica) 		PF01026
(TatD_DNase) 		4 GLY A 180
ASN A 200
GLU A 184
ILE A 188
 None
 0.99A 4fglD-3ipwA:
undetectable		 4fglD-3ipwA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		4 GLY A 557
GLY A 558
ASN A 561
ILE A 356
 None
THH  A 642 (-3.3A)
THH  A 642 ( 3.3A)
None
 0.95A 4fglD-3k13A:
undetectable		 4fglD-3k13A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsp DEST

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		4 GLY A 200
GLY A 201
MET A 146
ILE A 197
 None
 0.94A 4fglD-3lspA:
undetectable		 4fglD-3lspA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lx6 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		4 GLY A 107
GLY A 108
GLU A 451
ILE A 454
 None
 0.94A 4fglD-3lx6A:
3.8		 4fglD-3lx6A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		4 GLY A 107
GLY A 108
GLU A 451
ILE A 454
 None
 0.94A 4fglD-3me5A:
3.9		 4fglD-3me5A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om9 LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A 294
GLY A 297
MET A 159
ASN A 158
 None
 0.92A 4fglD-3om9A:
undetectable		 4fglD-3om9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 GLY A 549
ASN A 439
GLU A 551
ILE A 552
 None
 0.73A 4fglD-3pocA:
undetectable		 4fglD-3pocA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT

(Cryptococcus
neoformans) 		PF00432
(Prenyltrans) 		4 GLY B 313
GLY B 312
ASN B 376
ILE B  37
 None
 0.95A 4fglD-3q75B:
undetectable		 4fglD-3q75B:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2

(Rattus
norvegicus) 		PF01070
(FMN_dh) 		4 GLY A 280
GLY A 279
ASN A 246
ILE A 298
 FMN  A 401 (-3.8A)
FMN  A 401 (-3.4A)
None
None
 0.97A 4fglD-3sgzA:
undetectable		 4fglD-3sgzA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssz MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Rhodobacteraceae
bacterium KLH11) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 318
GLY A 317
MET A 135
ILE A 325
 None
 0.96A 4fglD-3sszA:
undetectable		 4fglD-3sszA:
20.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3te7 RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE]

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		6 GLY A 149
GLY A 150
MET A 154
ASN A 161
GLU A 193
ILE A 194
 FAD  A 232 (-3.6A)
FAD  A 232 (-3.6A)
None
None
FAD  A 232 ( 3.1A)
None
 0.20A 4fglD-3te7A:
38.9		 4fglD-3te7A:
98.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 GLY A 478
GLY A 476
GLU A 301
ILE A 209
 None
None
CPZ  A 501 (-3.8A)
None
 0.97A 4fglD-3tk3A:
undetectable		 4fglD-3tk3A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 GLY A 396
GLY A 397
ASN A 431
ILE A 384
 None
 0.98A 4fglD-3uk1A:
2.8		 4fglD-3uk1A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLY A1621
GLY A1622
ASN A1318
ILE A1557
 None
 0.95A 4fglD-3va7A:
undetectable		 4fglD-3va7A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 GLY A 519
MET A 495
GLU A 515
ILE A 514
 None
 0.94A 4fglD-3vueA:
4.4		 4fglD-3vueA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE

(Streptococcus
pneumoniae) 		PF00162
(PGK) 		4 GLY A 376
GLY A 377
GLU A 181
ILE A 185
 GOL  A1404 (-3.0A)
None
GOL  A1404 (-2.7A)
None
 0.90A 4fglD-3zlbA:
3.9		 4fglD-3zlbA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		4 GLY A 588
GLY A 589
GLU A 581
ILE A 584
 None
None
PLP  A1644 (-3.6A)
None
 0.92A 4fglD-4a0hA:
4.1		 4fglD-4a0hA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA

(Bos taurus) 		PF00118
(Cpn60_TCP1) 		4 GLY A  31
ASN A 440
GLU A 482
ILE A 480
 None
 0.64A 4fglD-4a0wA:
undetectable		 4fglD-4a0wA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3s 6-PHOSPHOFRUCTOKINAS
E

(Bacillus
subtilis) 		PF00365
(PFK) 		4 GLY A 185
GLY A 184
GLU A 187
ILE A 217
 None
 0.84A 4fglD-4a3sA:
4.5		 4fglD-4a3sA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 GLY B2365
GLY B2364
GLU B2370
ILE B2371
 None
 0.89A 4fglD-4bedB:
undetectable		 4fglD-4bedB:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cij GST REP

(Geobacillus
stearothermophilus) 		PF02486
(Rep_trans) 		4 GLY A 157
GLY A 158
GLU A 156
ILE A 155
 None
 0.87A 4fglD-4cijA:
undetectable		 4fglD-4cijA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8o ANKYRIN-2

(Homo sapiens) 		PF00531
(Death)
PF00791
(ZU5) 		4 GLY A1135
GLY A1136
ASN A1129
GLU A1152
 None
 0.97A 4fglD-4d8oA:
undetectable		 4fglD-4d8oA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dry 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		4 GLY A  19
GLY A  18
ASN A  95
ILE A  54
 None
 0.84A 4fglD-4dryA:
5.4		 4fglD-4dryA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 GLY A 681
GLY A 679
GLU A 742
ILE A 745
 BGC  A1003 ( 3.8A)
0NZ  A1004 (-3.2A)
BGC  A1003 (-2.7A)
None
 0.93A 4fglD-4f9oA:
undetectable		 4fglD-4f9oA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2u ENOYL-COA HYDRATASE

(Rhodobacter
sphaeroides) 		PF16113
(ECH_2) 		4 GLY A 147
GLY A 146
ASN A  92
ILE A 264
 None
 0.82A 4fglD-4j2uA:
undetectable		 4fglD-4j2uA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN

(Micromonospora
viridifaciens) 		PF13088
(BNR_2) 		4 GLY A 382
ASN A 395
GLU A 208
ILE A 315
 None
 0.81A 4fglD-4j9tA:
undetectable		 4fglD-4j9tA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		4 GLY A 139
GLY A 140
GLU A 126
ILE A 124
 None
 0.96A 4fglD-4o5pA:
undetectable		 4fglD-4o5pA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0j INTERLEUKIN-36
RECEPTOR
ANTAGONIST/INTERLEUK
IN-36 GAMMA CHIMERA
PROTEIN

(Homo sapiens) 		PF00340
(IL1) 		4 GLY A  63
GLY A  64
ASN A  84
GLU A  41
 None
 0.63A 4fglD-4p0jA:
undetectable		 4fglD-4p0jA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q05 ESTERASE E25

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 GLY A 184
GLY A 183
GLU A 132
ILE A 136
 None
 0.81A 4fglD-4q05A:
2.8		 4fglD-4q05A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 4 GLY A 157
GLY A 158
GLU A  57
ILE A  58
 None
 0.89A 4fglD-4q38A:
undetectable		 4fglD-4q38A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 GLY A 398
GLY A 399
GLU A 185
ILE A 184
 None
 0.93A 4fglD-4q6rA:
undetectable		 4fglD-4q6rA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qs9 HEXOKINASE-1

(Arabidopsis
thaliana) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 GLY A 254
GLY A 252
GLU A 315
ILE A 318
 BGC  A 501 ( 3.7A)
None
BGC  A 501 (-2.7A)
None
 0.92A 4fglD-4qs9A:
undetectable		 4fglD-4qs9A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLY A 147
GLY A 148
GLU A 124
ILE A 123
 None
 0.97A 4fglD-4zlgA:
undetectable		 4fglD-4zlgA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 GLY A 739
GLY A 738
ASN A 759
ILE A 671
 AMP  A1403 ( 3.3A)
AMP  A1403 ( 4.1A)
AMP  A1403 (-3.4A)
None
 0.88A 4fglD-4zxiA:
undetectable		 4fglD-4zxiA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 GLY A 783
GLY A 782
MET A 820
ASN A 823
 None
CL  A 903 ( 4.1A)
CL  A 903 ( 4.8A)
None
 0.98A 4fglD-5dllA:
undetectable		 4fglD-5dllA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 GLY A  79
GLY A  78
ASN A  98
GLU A  82
 None
 0.98A 4fglD-5dotA:
undetectable		 4fglD-5dotA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		4 GLY A 333
GLY A 334
GLU A 349
ILE A 350
 None
 0.97A 4fglD-5ej1A:
undetectable		 4fglD-5ej1A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evy SALICYLATE
HYDROXYLASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		4 GLY X 324
GLY X 326
ASN X  53
ILE X  15
 FAD  X 501 (-3.5A)
None
None
FAD  X 501 ( 4.2A)
 0.96A 4fglD-5evyX:
3.1		 4fglD-5evyX:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLY A1621
GLY A1622
ASN A1318
ILE A1557
 None
 0.96A 4fglD-5i8iA:
undetectable		 4fglD-5i8iA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na7 PUTATIVE
DIPEPTIDYL-PEPTIDASE
III

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLY A 239
GLY A 240
GLU A 247
ILE A 246
 None
 0.99A 4fglD-5na7A:
undetectable		 4fglD-5na7A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oa3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D

(Homo sapiens) 		no annotation 4 GLY 0  67
GLY 0  68
ASN 0 181
GLU 0  46
 None
 0.92A 4fglD-5oa30:
undetectable		 4fglD-5oa30:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN

(Geobacillus sp.
Y4.1MC1) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF13193
(AMP-binding_C) 		4 GLY A 725
GLY A 724
ASN A 745
ILE A 657
 MJ8  A1601 (-3.7A)
MJ8  A1601 ( 4.5A)
MJ8  A1601 (-3.5A)
MJ8  A1601 (-4.7A)
 0.74A 4fglD-5u89A:
undetectable		 4fglD-5u89A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM3

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF17207
(MCM_OB) 		4 GLY 3 304
GLY 3 305
ASN 3 307
ILE 3 315
 None
 0.99A 4fglD-5udb3:
undetectable		 4fglD-5udb3:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um8 GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 GLY G 471
GLY G 472
ASN G 477
ILE G 371
 None
 0.79A 4fglD-5um8G:
undetectable		 4fglD-5um8G:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvo DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		no annotation 4 GLY C 451
GLY C 452
ASN C 383
GLU C 450
 None
 0.90A 4fglD-5wvoC:
undetectable		 4fglD-5wvoC:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 22

(Homo sapiens) 		no annotation 4 GLY A 430
GLY A 431
ASN A 526
ILE A 378
 None
None
CA  A 803 (-3.2A)
None
 0.99A 4fglD-5y31A:
undetectable		 4fglD-5y31A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yd0 SCHLAFEN 8

(Rattus
norvegicus) 		no annotation 4 GLY A 239
GLY A 240
ASN A 184
ILE A 231
 None
 0.91A 4fglD-5yd0A:
undetectable		 4fglD-5yd0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfp EXOCYST COMPLEX
COMPONENT SEC6

(Saccharomyces
cerevisiae) 		no annotation 4 GLY C 540
GLY C 539
ASN C 521
GLU C 543
 None
 0.91A 4fglD-5yfpC:
undetectable		 4fglD-5yfpC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykd D-HYDANTOINASE/DIHYD
ROPYRIMIDINASE

(Pseudomonas
aeruginosa) 		no annotation 4 GLY A  85
GLY A  86
GLU A 343
ILE A 342
 None
 0.94A 4fglD-5ykdA:
undetectable		 4fglD-5ykdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0c NEROL DEHYDROGENASE

(Persicaria
minor) 		no annotation 4 GLY A 306
GLY A 305
GLU A 115
ILE A 100
 None
 0.89A 4fglD-5z0cA:
4.4		 4fglD-5z0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zby HYDROGENASE
MATURATION PROTEASE
HYCI

(Thermococcus
kodakarensis) 		no annotation 4 GLY A  80
GLY A  79
GLU A  84
ILE A  86
 None
 0.87A 4fglD-5zbyA:
4.1		 4fglD-5zbyA:
undetectable