SIMILAR PATTERNS OF AMINO ACIDS FOR 4FGL_C_CLQC303_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqg D-GLUCARATE
DEHYDRATASE

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A  57
VAL A  56
HIS A  55
GLN A 132
 None
 0.83A 4fglD-1bqgA:
0.4		 4fglD-1bqgA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri) 		PF00089
(Trypsin) 		4 GLY A  44
VAL A  31
PHE A 209
ILE A  47
 None
 0.68A 4fglD-1bqyA:
undetectable		 4fglD-1bqyA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 GLY A 908
VAL A 787
HIS A 788
PHE A 367
 None
K  A4009 ( 4.4A)
ADP  A4006 (-4.2A)
None
 0.97A 4fglD-1c30A:
3.4		 4fglD-1c30A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ASN A  49
GLY A  51
PHE A  79
ILE A  83
 None
 0.94A 4fglD-1i2dA:
3.0		 4fglD-1i2dA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j93 UROPORPHYRINOGEN
DECARBOXYLASE

(Nicotiana
tabacum) 		PF01208
(URO-D) 		4 GLY A 164
VAL A 103
ILE A  92
PHE A 190
 None
 0.80A 4fglD-1j93A:
undetectable		 4fglD-1j93A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		4 ASN A 646
GLY A  26
VAL A  27
ILE A  20
 None
 0.95A 4fglD-1kehA:
undetectable		 4fglD-1kehA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kj9 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE 2

(Escherichia
coli) 		PF02222
(ATP-grasp) 		4 GLY A 196
VAL A 197
ILE A 168
PHE A 141
 EDO  A 402 ( 3.2A)
ATP  A   1 (-3.9A)
None
None
 0.82A 4fglD-1kj9A:
2.9		 4fglD-1kj9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE

(Klebsiella sp.
LX3) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLY A 593
VAL A 594
ILE A 395
PHE A 551
 None
 0.91A 4fglD-1m53A:
0.0		 4fglD-1m53A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1op2 VENOM SERINE
PROTEINASE

(Deinagkistrodon
acutus) 		PF00089
(Trypsin) 		4 GLY A  44
VAL A  31
PHE A 209
ILE A  47
 None
 0.72A 4fglD-1op2A:
undetectable		 4fglD-1op2A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s8e EXONUCLEASE PUTATIVE

(Pyrococcus
furiosus) 		PF00149
(Metallophos) 		4 GLY A 142
HIS A 141
ILE A 169
PHE A  43
 None
 0.92A 4fglD-1s8eA:
undetectable		 4fglD-1s8eA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1scm MYOSIN ESSENTIAL
LIGHT CHAIN

(Argopecten
irradians) 		PF13499
(EF-hand_7) 		4 GLY C  53
VAL C  52
PHE C  68
PHE C  15
 None
 0.94A 4fglD-1scmC:
undetectable		 4fglD-1scmC:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tw9 GLUTATHIONE
S-TRANSFERASE 2

(Heligmosomoides
polygyrus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ASN A 143
GLY A 146
HIS A 184
ILE A 153
 None
 0.94A 4fglD-1tw9A:
undetectable		 4fglD-1tw9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tye INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 GLY B 221
PHE B 248
ILE B 226
PHE B 308
 None
 0.80A 4fglD-1tyeB:
3.2		 4fglD-1tyeB:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		4 GLY A 132
VAL A 133
PHE A 144
ILE A 111
 None
 0.86A 4fglD-1vclA:
undetectable		 4fglD-1vclA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmo VITELLINE MEMBRANE
OUTER LAYER PROTEIN
I

(Gallus gallus) 		PF03762
(VOMI) 		4 GLY A 120
PHE A  34
ILE A  53
PHE A 108
 None
 0.87A 4fglD-1vmoA:
undetectable		 4fglD-1vmoA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3t HYPOTHETICAL PROTEIN
YXAG

(Bacillus
subtilis) 		PF07883
(Cupin_2) 		4 GLY A 288
VAL A 289
PHE A 299
ILE A 207
 None
 0.94A 4fglD-1y3tA:
undetectable		 4fglD-1y3tA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc4 RAS-RELATED PROTEIN
RAL-A

(Homo sapiens) 		PF00071
(Ras) 		4 GLY A  21
VAL A  92
PHE A  83
ILE A  18
 None
 0.79A 4fglD-1zc4A:
4.6		 4fglD-1zc4A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00155
(Aminotran_1_2) 		4 GLY A 408
VAL A 407
PHE A 350
PHE A 352
 None
 0.77A 4fglD-2ay9A:
2.8		 4fglD-2ay9A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkk BASEPLATE STRUCTURAL
PROTEIN GP10

(Escherichia
virus T4) 		no annotation 4 ASN A 502
GLY A 517
PHE A 481
ILE A 428
 None
 0.79A 4fglD-2fkkA:
undetectable		 4fglD-2fkkA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Aquifex
aeolicus) 		PF00308
(Bac_DnaA)
PF08299
(Bac_DnaA_C) 		4 ASN A 113
PHE A 195
ILE A 198
PHE A 151
 None
 0.90A 4fglD-2hcbA:
undetectable		 4fglD-2hcbA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU

(Streptococcus
pneumoniae) 		PF01895
(PhoU) 		4 VAL A 205
PHE A 137
ILE A 200
PHE A  16
 None
 0.84A 4fglD-2i0mA:
undetectable		 4fglD-2i0mA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu5 HTH-TYPE DHAKLM
OPERON
TRANSCRIPTIONAL
ACTIVATOR DHAS

(Lactococcus
lactis) 		PF00440
(TetR_N) 		4 ASN A  67
GLN A 110
PHE A 106
ILE A 109
 None
 0.86A 4fglD-2iu5A:
undetectable		 4fglD-2iu5A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8s AGR_C_984P

(Agrobacterium
fabrum) 		PF06748
(DUF1217) 		4 ASN A 193
GLY A 195
VAL A 196
ILE A 271
 None
 0.75A 4fglD-2o8sA:
undetectable		 4fglD-2o8sA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odr PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanococcus
maripaludis) 		PF01409
(tRNA-synt_2d) 		4 GLY B 190
GLN B  81
PHE B  82
ILE B  78
 None
 0.82A 4fglD-2odrB:
undetectable		 4fglD-2odrB:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06471
(NSP11) 		4 GLY A 253
PHE A 240
ILE A 295
PHE A 329
 None
 0.95A 4fglD-2ozkA:
undetectable		 4fglD-2ozkA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p24 H-2 CLASS II
HISTOCOMPATIBILITY
ANTIGEN, A-U ALPHA
CHAIN

(Mus musculus) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 GLY A   7
VAL A   6
HIS A   5
PHE A  48
 None
 0.82A 4fglD-2p24A:
undetectable		 4fglD-2p24A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3v INOSITOL-1-MONOPHOSP
HATASE

(Thermotoga
maritima) 		PF00459
(Inositol_P) 		4 GLY A1015
VAL A1014
PHE A1094
ILE A1081
 None
 0.96A 4fglD-2p3vA:
2.1		 4fglD-2p3vA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3y VIRULENCE FACTOR

(Pectobacterium
carotovorum) 		no annotation 4 GLY A 152
PHE A 198
ILE A 205
PHE A 219
 PLM  A1278 ( 4.2A)
None
None
PLM  A1278 ( 3.7A)
 0.95A 4fglD-2w3yA:
undetectable		 4fglD-2w3yA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		4 ASN A 280
GLY A 560
VAL A 561
PHE A 582
 None
 0.93A 4fglD-2w92A:
undetectable		 4fglD-2w92A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anx SPERMIDINE SYNTHASE

(Thermus
thermophilus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 VAL A  53
PHE A 234
ILE A 227
PHE A 236
 None
 0.86A 4fglD-3anxA:
2.6		 4fglD-3anxA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A  82
VAL A  74
ILE A  71
PHE A 374
 None
 0.81A 4fglD-3bjsA:
undetectable		 4fglD-3bjsA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce1 SUPEROXIDE DISMUTASE
[CU-ZN]

(Naganishia
liquefaciens) 		PF00080
(Sod_Cu) 		4 GLY A 151
VAL A 152
PHE A  23
ILE A 116
 None
 0.87A 4fglD-3ce1A:
undetectable		 4fglD-3ce1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Enterococcus
faecalis) 		PF13377
(Peripla_BP_3) 		4 GLY A  63
VAL A  64
PHE A 127
ILE A 134
 None
 0.87A 4fglD-3cs3A:
undetectable		 4fglD-3cs3A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5n Q97W15_SULSO

(Sulfolobus
solfataricus) 		PF12804
(NTP_transf_3) 		4 GLY A   4
VAL A   5
PHE A 138
ILE A 133
 None
 0.89A 4fglD-3d5nA:
undetectable		 4fglD-3d5nA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fna POSSIBLE ARABINOSE
5-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00571
(CBS) 		4 GLY A 322
VAL A 323
HIS A 218
ILE A 216
 None
 0.87A 4fglD-3fnaA:
undetectable		 4fglD-3fnaA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		4 ASN A 280
GLY A 560
VAL A 561
PHE A 582
 None
 0.94A 4fglD-3gdbA:
undetectable		 4fglD-3gdbA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hig AMILORIDE-SENSITIVE
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 GLY A 524
PHE A 701
ILE A 346
PHE A 702
 None
 0.93A 4fglD-3higA:
undetectable		 4fglD-3higA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 4 ASN A 227
GLY A 226
VAL A 225
HIS A 224
 None
 0.96A 4fglD-3j3iA:
undetectable		 4fglD-3j3iA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1l FANCL

(Drosophila
melanogaster) 		no annotation 4 VAL B 341
HIS B 339
ILE B 313
PHE B 366
 None
ZN  B 383 (-2.7A)
None
None
 0.96A 4fglD-3k1lB:
undetectable		 4fglD-3k1lB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4w UNCHARACTERIZED
PROTEIN BB4693

(Bordetella
bronchiseptica) 		PF04909
(Amidohydro_2) 		4 ASN A 121
GLY A  66
VAL A  65
ILE A  20
 None
 0.89A 4fglD-3k4wA:
undetectable		 4fglD-3k4wA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 GLY A 405
VAL A 404
HIS A 401
ILE A 379
 None
 0.89A 4fglD-3kbhA:
undetectable		 4fglD-3kbhA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxp PRETHROMBIN-1

(Homo sapiens) 		PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light) 		4 ASN A 221
GLY A 224
PHE A 280
PHE A 281
 None
 0.84A 4fglD-3nxpA:
undetectable		 4fglD-3nxpA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojl CAP5O

(Staphylococcus
aureus) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 GLY A 171
VAL A 147
HIS A 148
ILE A 168
 None
 0.93A 4fglD-3ojlA:
4.8		 4fglD-3ojlA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqb OXIDOREDUCTASE

(Bradyrhizobium
diazoefficiens) 		PF01408
(GFO_IDH_MocA) 		4 GLY A  13
VAL A  14
PHE A  87
ILE A  10
 None
 0.88A 4fglD-3oqbA:
4.0		 4fglD-3oqbA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s69 THROMBIN-LIKE ENZYME
DEFIBRASE

(Gloydius
saxatilis) 		PF00089
(Trypsin) 		4 GLY A  43
VAL A  31
PHE A 205
ILE A  46
 None
 0.74A 4fglD-3s69A:
undetectable		 4fglD-3s69A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6p CAPSID PROTEIN

(Helicoverpa
armigera stunt
virus) 		PF03566
(Peptidase_A21) 		4 GLY A 265
HIS A 513
PHE A 514
ILE A 157
 None
 0.94A 4fglD-3s6pA:
undetectable		 4fglD-3s6pA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 ASN A 542
GLY A 541
ILE A 517
PHE A 568
 None
 0.90A 4fglD-3syjA:
undetectable		 4fglD-3syjA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 GLY A 549
VAL A 550
ILE A 501
PHE A 473
 None
 0.91A 4fglD-3szeA:
undetectable		 4fglD-3szeA:
12.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3te7 RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE]

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		8 ASN A  66
GLY A  68
VAL A  69
HIS A  72
GLN A 122
PHE A 126
ILE A 128
PHE A 178
 None
TE7  A   1 ( 4.1A)
None
None
TE7  A   1 ( 4.3A)
TE7  A   1 (-4.3A)
None
TE7  A   1 (-3.6A)
 0.53A 4fglD-3te7A:
38.9		 4fglD-3te7A:
98.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0o SELENIDE, WATER
DIKINASE

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ASN A 277
GLY A 232
GLN A 300
ILE A 182
 None
 0.95A 4fglD-3u0oA:
undetectable		 4fglD-3u0oA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00155
(Aminotran_1_2) 		4 GLY A 209
HIS A 217
GLN A 213
PHE A  92
 None
 0.90A 4fglD-3wy7A:
undetectable		 4fglD-3wy7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00155
(Aminotran_1_2) 		4 GLY A 214
HIS A 217
GLN A 213
PHE A  92
 None
 0.93A 4fglD-3wy7A:
undetectable		 4fglD-3wy7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PDX2 PROTEIN

(Plasmodium
falciparum) 		PF01174
(SNO) 		4 GLY G   7
VAL G   8
PHE G  75
ILE G  83
 None
 0.86A 4fglD-4adsG:
4.3		 4fglD-4adsG:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgv MALATE DEHYDROGENASE

(Picrophilus
torridus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A 109
VAL A 108
PHE A 320
ILE A 102
 None
 0.77A 4fglD-4bgvA:
5.0		 4fglD-4bgvA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi5 TRIOSEPHOSPHATE
ISOMERASE

(Giardia
intestinalis) 		PF00121
(TIM) 		4 GLY A 192
VAL A 189
HIS A 190
ILE A 167
 None
 0.79A 4fglD-4bi5A:
undetectable		 4fglD-4bi5A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		4 GLY B 221
PHE B 248
ILE B 226
PHE B 308
 None
 0.82A 4fglD-4cakB:
undetectable		 4fglD-4cakB:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 GLY A 366
HIS A 376
ILE A 338
PHE A 395
 None
 0.74A 4fglD-4cvqA:
undetectable		 4fglD-4cvqA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A  94
VAL A  95
HIS A 126
PHE A  50
 None
 0.97A 4fglD-4f7kA:
undetectable		 4fglD-4f7kA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwm PROPIONATE KINASE

(Salmonella
enterica) 		PF00871
(Acetate_kinase) 		4 GLY A 343
VAL A 344
ILE A 308
PHE A 323
 None
 0.95A 4fglD-4fwmA:
undetectable		 4fglD-4fwmA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1k TRIOSEPHOSPHATE
ISOMERASE

(Burkholderia
thailandensis) 		PF00121
(TIM) 		4 GLY A  43
VAL A  44
ILE A 233
PHE A 223
 None
 0.84A 4fglD-4g1kA:
undetectable		 4fglD-4g1kA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Flavobacterium
johnsoniae) 		PF01884
(PcrB) 		4 GLY A 208
VAL A 207
ILE A 217
PHE A 240
 1GP  A 301 (-3.4A)
None
None
None
 0.86A 4fglD-4jejA:
undetectable		 4fglD-4jejA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo8 M157

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 GLY A 170
GLN A 102
PHE A  98
ILE A 101
 None
 0.72A 4fglD-4jo8A:
undetectable		 4fglD-4jo8A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2

(Homo sapiens;
Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF17205
(PSI_integrin) 		4 GLY A 412
PHE B 247
ILE A 435
PHE B 245
 None
 0.82A 4fglD-4nenA:
4.3		 4fglD-4nenA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A 347
VAL A 348
PHE A 410
ILE A 354
 None
 0.85A 4fglD-4qavA:
undetectable		 4fglD-4qavA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv3 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE

(Staphylococcus
aureus) 		PF00388
(PI-PLC-X) 		4 GLY A  60
PHE A  64
ILE A 108
PHE A  92
 None
 0.88A 4fglD-4rv3A:
undetectable		 4fglD-4rv3A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 GLY B 224
PHE B 251
ILE B 229
PHE B 311
 None
 0.63A 4fglD-4um8B:
3.8		 4fglD-4um8B:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		4 ASN A 141
GLY A 142
PHE A 129
ILE A 215
 None
 0.97A 4fglD-4v20A:
undetectable		 4fglD-4v20A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrw URACIL-DNA
GLYCOSYLASE

(Mycobacterium
tuberculosis) 		PF03167
(UDG) 		4 ASN A 127
GLY A  66
ILE A  97
PHE A 207
 GOL  A 307 (-2.8A)
GOL  A 307 (-3.5A)
None
None
 0.89A 4fglD-4wrwA:
undetectable		 4fglD-4wrwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ

(Escherichia
coli) 		PF03180
(Lipoprotein_9) 		4 GLY X  36
VAL X  64
PHE X 246
ILE X  33
 None
 0.96A 4fglD-4yahX:
undetectable		 4fglD-4yahX:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
aeruginosa) 		PF00275
(EPSP_synthase) 		4 ASN A 317
GLY A 324
VAL A 357
ILE A 327
 None
 0.96A 4fglD-5bq2A:
undetectable		 4fglD-5bq2A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwi GLYCOSIDE HYDROLASE
FAMILY 79

(Burkholderia
pseudomallei) 		PF12891
(Glyco_hydro_44) 		4 GLY A 287
PHE A  30
ILE A  26
PHE A 327
 None
 0.95A 4fglD-5bwiA:
undetectable		 4fglD-5bwiA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlb CHAPERONE ESPG3

(Mycobacterium
marinum) 		PF14011
(ESX-1_EspG) 		4 GLY A  64
VAL A  65
PHE A  17
PHE A  47
 None
 0.94A 4fglD-5dlbA:
undetectable		 4fglD-5dlbA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L
INTEGRIN BETA-2

(Homo sapiens;
Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 GLY A 406
PHE B 247
ILE A 431
PHE B 245
 None
 0.90A 4fglD-5e6sA:
5.7		 4fglD-5e6sA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Homo sapiens) 		PF01652
(IF4E) 		4 ASN A 213
GLY A 196
VAL A 216
ILE A 193
 None
 0.88A 4fglD-5ei3A:
undetectable		 4fglD-5ei3A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP4

(Saccharomyces
cerevisiae) 		PF14382
(ECR1_N)
PF15985
(KH_6) 		4 ASN H 228
GLY H 226
VAL H 112
HIS H 111
 None
 0.78A 4fglD-5g06H:
undetectable		 4fglD-5g06H:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 GLY A1931
VAL A1932
PHE A2022
ILE A2026
 None
 0.94A 4fglD-5i6gA:
undetectable		 4fglD-5i6gA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 GLY A1931
VAL A1932
PHE A2022
ILE A2026
 None
 0.92A 4fglD-5i6iA:
undetectable		 4fglD-5i6iA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihw SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN E

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		4 ASN A 533
GLY A 470
PHE A 438
ILE A 564
 None
 0.96A 4fglD-5ihwA:
undetectable		 4fglD-5ihwA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES

(Corynebacterium
glutamicum) 		PF00933
(Glyco_hydro_3) 		4 GLY A 178
VAL A 179
PHE A 127
ILE A  98
 None
 0.71A 4fglD-5iobA:
undetectable		 4fglD-5iobA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9n POLYAMINE N
ACETYLTRANSFERASE

(Drosophila
melanogaster) 		PF00583
(Acetyltransf_1) 		4 GLY A 132
VAL A 133
HIS A  29
ILE A  71
 None
 0.69A 4fglD-5k9nA:
undetectable		 4fglD-5k9nA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kia L-THREONINE
3-DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 114
VAL A 113
HIS A  63
PHE A 325
 None
 0.94A 4fglD-5kiaA:
3.5		 4fglD-5kiaA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA

(Mus musculus) 		PF01532
(Glyco_hydro_47) 		4 ASN A 394
GLY A 414
ILE A 461
PHE A 484
 None
 0.64A 4fglD-5kkbA:
undetectable		 4fglD-5kkbA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kl0 PHOSPHOGLUCOMUTASE

(Xanthomonas
citri) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 GLY A 358
HIS A 347
PHE A 267
PHE A 254
 None
 0.93A 4fglD-5kl0A:
undetectable		 4fglD-5kl0A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn7 URACIL-DNA
GLYCOSYLASE

(Human
gammaherpesvirus
8) 		no annotation 4 GLY A 141
VAL A 142
ILE A 175
PHE A  34
 None
 0.95A 4fglD-5nn7A:
undetectable		 4fglD-5nn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oge GDP-MANNOSE
TRANSPORTER 1

(Saccharomyces
cerevisiae) 		no annotation 4 ASN A 288
GLY A 285
VAL A 284
PHE A 198
 None
 0.93A 4fglD-5ogeA:
undetectable		 4fglD-5ogeA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN

(Bos taurus) 		PF00654
(Voltage_CLC) 		4 ASN A 509
GLY A 476
PHE A 426
PHE A 213
 None
 0.94A 4fglD-5tr1A:
undetectable		 4fglD-5tr1A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0a GLUCANASE

(Trichoderma
harzianum) 		no annotation 4 ASN A 142
GLY A 143
PHE A 130
ILE A 199
 ASN  A 142 ( 0.6A)
GLY  A 143 ( 0.0A)
PHE  A 130 ( 1.3A)
ILE  A 199 ( 0.7A)
 0.93A 4fglD-5w0aA:
undetectable		 4fglD-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3w ARYLDIALKYLPHOSPHATA
SE

(Sulfolobus
solfataricus) 		no annotation 4 ASN A 236
PHE A 305
ILE A 301
PHE A  18
 None
 0.93A 4fglD-5w3wA:
undetectable		 4fglD-5w3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo sapiens) 		no annotation 4 GLY A1558
VAL A1557
GLN A1573
ILE A1572
 None
 0.87A 4fglD-5wchA:
undetectable		 4fglD-5wchA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		4 GLY A 166
PHE A 262
ILE A 189
PHE A 206
 None
 0.90A 4fglD-5x2qA:
4.5		 4fglD-5x2qA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE ALPHA
SUBUNIT

(Diaphorobacter
sp. DS2) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 GLY A 296
VAL A 201
ILE A 204
PHE A 222
 None
 0.93A 4fglD-5xbpA:
undetectable		 4fglD-5xbpA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y83 MEMBRANE PROTEIN
INSERTASE YIDC

(Thermotoga
maritima) 		no annotation 4 GLY A  91
VAL A  92
ILE A 118
PHE A  44
 None
 0.94A 4fglD-5y83A:
undetectable		 4fglD-5y83A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zhz PROBABLE
ENDONUCLEASE 4

(Mycobacterium
tuberculosis) 		no annotation 4 ASN A 193
HIS A   6
GLN A  25
ILE A  94
 ZN  A 305 ( 4.9A)
None
None
None
 0.78A 4fglD-5zhzA:
undetectable		 4fglD-5zhzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zi9 CYTOKININ RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE

(Streptomyces
coelicolor) 		no annotation 4 ASN A 144
GLY A 111
PHE A 163
ILE A 108
 None
 0.89A 4fglD-5zi9A:
5.3		 4fglD-5zi9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT F

(Flavobacterium
johnsoniae) 		no annotation 4 GLN F 131
PHE F 127
ILE F 130
PHE F 287
 None
 0.80A 4fglD-6btmF:
undetectable		 4fglD-6btmF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4

(Homo sapiens) 		no annotation 4 GLY A 263
VAL A 264
ILE A 270
PHE A 281
 None
 0.92A 4fglD-6c90A:
undetectable		 4fglD-6c90A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
putida) 		no annotation 4 ASN A 317
GLY A 324
VAL A 357
ILE A 327
 None
 0.90A 4fglD-6cn1A:
undetectable		 4fglD-6cn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
COMPONENT RRP40

(Homo sapiens) 		no annotation 4 ASN G 234
GLY G 232
VAL G 117
ILE G 193
 None
 0.89A 4fglD-6d6qG:
undetectable		 4fglD-6d6qG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME RNA HELICASE
MTR4

(Homo sapiens) 		no annotation 4 GLY M 263
VAL M 264
ILE M 270
PHE M 281
 None
 0.70A 4fglD-6d6qM:
undetectable		 4fglD-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gii CYTOCHROME P450

(Tepidiphilus
thermophilus) 		no annotation 4 GLY A 219
VAL A 220
ILE A 305
PHE A 170
 None
None
HEM  A 501 ( 4.4A)
HEM  A 501 ( 4.2A)
 0.91A 4fglD-6giiA:
undetectable		 4fglD-6giiA:
undetectable