SIMILAR PATTERNS OF AMINO ACIDS FOR 4FGL_C_CLQC303_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coy CHOLESTEROL OXIDASE

(Brevibacterium
sterolicum) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A 114
GLY A 115
ASN A 119
GLU A  41
 FAD  A 510 (-3.0A)
FAD  A 510 (-3.4A)
FAD  A 510 (-4.1A)
FAD  A 510 (-2.7A)
 1.29A 4fglC-1coyA:
2.8		 4fglC-1coyA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coy CHOLESTEROL OXIDASE

(Brevibacterium
sterolicum) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A 214
GLY A 215
MET A  59
GLU A 203
 None
None
AND  A 508 ( 4.0A)
None
 1.21A 4fglC-1coyA:
2.8		 4fglC-1coyA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		4 GLY A 508
GLY A 507
ASN A 505
GLU A 207
 None
 0.87A 4fglC-1fehA:
undetectable		 4fglC-1fehA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		4 GLY C 102
GLY C 101
ASN C  97
GLU C 106
 None
 1.16A 4fglC-1h2tC:
undetectable		 4fglC-1h2tC:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1md6 INTERLEUKIN 1
FAMILY, MEMBER 5
(DELTA)

(Mus musculus) 		PF00340
(IL1) 		4 GLY A  62
GLY A  63
ASN A  83
GLU A  40
 None
 0.80A 4fglC-1md6A:
undetectable		 4fglC-1md6A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1naa CELLOBIOSE
DEHYDROGENASE

(Phanerochaete
chrysosporium) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A 304
GLY A 305
ASN A 309
GLU A 246
 6FA  A 801 (-3.0A)
6FA  A 801 (-3.5A)
6FA  A 801 (-3.9A)
6FA  A 801 (-2.8A)
 1.23A 4fglC-1naaA:
3.1		 4fglC-1naaA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ntg TYROSYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF01588
(tRNA_bind) 		4 GLY A 166
GLY A 167
ASN A 168
GLU A 141
 None
 1.17A 4fglC-1ntgA:
undetectable		 4fglC-1ntgA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og6 HYPOTHETICAL
OXIDOREDUCTASE YDHF

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		4 GLY A 213
GLY A 215
ASN A 219
GLU A 182
 NAP  A1298 (-4.0A)
NAP  A1298 (-3.0A)
None
None
 1.18A 4fglC-1og6A:
undetectable		 4fglC-1og6A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdz ENOLASE

(Homarus
gammarus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 GLY A 155
GLY A 154
ASN A 160
GLU A 249
 None
 1.30A 4fglC-1pdzA:
undetectable		 4fglC-1pdzA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvl LEUCOCIDIN

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		4 GLY A 180
MET A 192
ASN A 190
GLU A 167
 None
 1.28A 4fglC-1pvlA:
undetectable		 4fglC-1pvlA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbl PECTATE LYASE 47

(Bacillus sp.
TS-47) 		PF00544
(Pec_lyase_C) 		4 GLY A 147
GLY A 148
MET A 127
GLU A 166
 None
 0.79A 4fglC-1vblA:
undetectable		 4fglC-1vblA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		4 GLY A  82
GLY A  81
ASN A  57
GLU A 112
 None
 1.26A 4fglC-2afbA:
4.2		 4fglC-2afbA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzw APOPTOSIS REGULATOR
BCL-X

(Mus musculus) 		PF00452
(Bcl-2)
PF02180
(BH4) 		4 GLY A 148
GLY A 147
MET A 170
GLU A  98
 None
 1.20A 4fglC-2bzwA:
undetectable		 4fglC-2bzwA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjl SECRETED CHITINASE

(Streptomyces
coelicolor) 		PF00182
(Glyco_hydro_19) 		4 GLY A 210
GLY A 211
ASN A 212
GLU A 208
 None
 1.12A 4fglC-2cjlA:
undetectable		 4fglC-2cjlA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d52 PENTAKETIDE CHROMONE
SYNTHASE

(Aloe
arborescens) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 GLY A 380
GLY A 378
MET A 365
GLU A 382
 None
 1.16A 4fglC-2d52A:
undetectable		 4fglC-2d52A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbc UNNAMED PROTEIN
PRODUCT

(Mus musculus) 		PF02114
(Phosducin) 		4 GLY A 103
GLY A 104
MET A  44
GLU A 111
 None
 1.20A 4fglC-2dbcA:
undetectable		 4fglC-2dbcA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG

(Aquifex
aeolicus) 		PF01434
(Peptidase_M41) 		4 GLY A 476
GLY A 475
MET A 425
GLU A 480
 None
 1.09A 4fglC-2di4A:
undetectable		 4fglC-2di4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpp NITRILE HYDRATASE
ALPHA SUBUNIT

(Bacillus sp.
RAPc8) 		PF02979
(NHase_alpha) 		4 GLY A 128
GLY A  59
MET A  61
ASN A  62
 None
 1.08A 4fglC-2dppA:
undetectable		 4fglC-2dppA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpw HYPOTHETICAL PROTEIN
TTHA0179

(Thermus
thermophilus) 		PF12804
(NTP_transf_3) 		4 GLY A  11
GLY A  10
ASN A  75
GLU A  13
 None
 1.31A 4fglC-2dpwA:
undetectable		 4fglC-2dpwA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		4 GLY A 153
GLY A 131
MET A 421
ASN A 424
 None
GLN  A 501 ( 4.5A)
None
None
 0.90A 4fglC-2f2aA:
undetectable		 4fglC-2f2aA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fre NAD(P)H-FLAVIN
OXIDOREDUCTASE

(Agrobacterium
fabrum) 		PF00881
(Nitroreductase) 		4 GLY A 136
GLY A 137
MET A  75
ASN A  78
 FMN  A1151 (-3.9A)
FMN  A1151 (-3.7A)
None
FMN  A1151 (-3.0A)
 1.00A 4fglC-2freA:
undetectable		 4fglC-2freA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g39 ACETYL-COA HYDROLASE

(Pseudomonas
aeruginosa) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 GLY A 372
GLY A 373
ASN A 367
GLU A 489
 None
 1.16A 4fglC-2g39A:
undetectable		 4fglC-2g39A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		4 GLY A 435
GLY A 434
MET A 533
GLU A 551
 None
None
None
CAC  A 705 ( 4.8A)
 1.11A 4fglC-2i0kA:
undetectable		 4fglC-2i0kA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iir ACETATE KINASE

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		4 GLY A  95
GLY A  94
ASN A 123
GLU A  96
 None
 1.15A 4fglC-2iirA:
undetectable		 4fglC-2iirA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k0d COLICIN-E7 IMMUNITY
PROTEIN

(Escherichia
coli) 		PF01320
(Colicin_Pyocin) 		4 GLY X  69
GLY X  70
ASN X  64
GLU X  78
 None
 1.01A 4fglC-2k0dX:
undetectable		 4fglC-2k0dX:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm1 GLUCOKINASE

(Enterococcus
faecalis) 		PF00480
(ROK) 		4 GLY A 144
GLY A 145
ASN A 116
GLU A 185
 None
MG  A1007 (-4.6A)
MG  A1007 (-2.8A)
None
 1.14A 4fglC-2qm1A:
undetectable		 4fglC-2qm1A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 GLY A  40
GLY A  76
ASN A 113
GLU A  38
 None
 1.23A 4fglC-2vw8A:
undetectable		 4fglC-2vw8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3n CARBONIC ANHYDRASE 2

(Cryptococcus
neoformans) 		PF00484
(Pro_CA) 		4 GLY A 192
MET A 112
ASN A 108
GLU A 195
 None
 0.95A 4fglC-2w3nA:
2.4		 4fglC-2w3nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze0 ALPHA-GLUCOSIDASE

(Geobacillus sp.
HTA-462) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLY A 259
MET A 229
ASN A 230
GLU A 283
 None
 1.26A 4fglC-2ze0A:
undetectable		 4fglC-2ze0A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLY A 661
GLY A 662
MET A 713
GLU A 718
 None
 0.62A 4fglC-3actA:
undetectable		 4fglC-3actA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnj CHOLESTEROL OXIDASE

(Streptomyces
sp. SA-COO) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A 114
GLY A 115
ASN A 119
GLU A  40
 FAD  A 510 (-3.0A)
FAD  A 510 (-3.4A)
FAD  A 510 (-3.9A)
FAD  A 510 (-2.7A)
 1.27A 4fglC-3cnjA:
2.2		 4fglC-3cnjA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czm L-LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A 295
GLY A 296
MET A 159
ASN A 158
 None
 1.29A 4fglC-3czmA:
5.1		 4fglC-3czmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czm L-LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A 295
GLY A 297
MET A 159
ASN A 158
 None
 1.12A 4fglC-3czmA:
5.1		 4fglC-3czmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 121
GLY A 120
ASN A  84
GLU A 542
 None
None
NAG  A 700 (-3.9A)
None
 1.01A 4fglC-3dkhA:
undetectable		 4fglC-3dkhA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		4 GLY A 411
GLY A 412
ASN A 140
GLU A 114
 CL  A 505 ( 4.0A)
None
None
ZN  A 504 ( 2.2A)
 1.30A 4fglC-3hq2A:
undetectable		 4fglC-3hq2A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iah SHORT CHAIN
DEHYDROGENASE YCIK

(Salmonella
enterica) 		PF00106
(adh_short) 		4 GLY A 197
GLY A 196
ASN A 194
GLU A 210
 NAP  A 254 (-3.3A)
NAP  A 254 (-4.6A)
None
None
 1.07A 4fglC-3iahA:
6.8		 4fglC-3iahA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ife PEPTIDASE T

(Bacillus
anthracis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLY A 201
GLY A 200
ASN A 372
GLU A 378
 None
 1.29A 4fglC-3ifeA:
2.4		 4fglC-3ifeA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		4 GLY X 354
MET X 357
ASN X 358
GLU X 877
 None
 1.15A 4fglC-3lxuX:
2.8		 4fglC-3lxuX:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdq EXOPOLYPHOSPHATASE

(Cytophaga
hutchinsonii) 		PF02541
(Ppx-GppA) 		4 GLY A 140
GLY A 139
ASN A  13
GLU A 159
 SO4  A 317 (-3.4A)
SO4  A 317 (-3.8A)
SO4  A 318 (-3.8A)
None
 1.22A 4fglC-3mdqA:
undetectable		 4fglC-3mdqA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nu1 HEMIN-BINDING
PERIPLASMIC PROTEIN

(Yersinia pestis) 		PF01497
(Peripla_BP_2) 		4 GLY A  34
GLY A  33
MET A  71
GLU A  38
 None
 1.25A 4fglC-3nu1A:
undetectable		 4fglC-3nu1A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		4 GLY A 311
GLY A 312
MET A 277
GLU A 360
 SO4  A 701 ( 3.8A)
SO4  A 701 (-4.2A)
None
None
 1.22A 4fglC-3nzqA:
undetectable		 4fglC-3nzqA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om9 LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A 295
GLY A 297
MET A 159
ASN A 158
 None
 1.12A 4fglC-3om9A:
4.6		 4fglC-3om9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm9 PUTATIVE
OXIDOREDUCTASE

(Rhodopseudomonas
palustris) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 GLY A  88
GLY A  89
ASN A 470
GLU A  42
 None
FAD  A 476 (-3.7A)
FAD  A 476 (-4.0A)
None
 1.16A 4fglC-3pm9A:
undetectable		 4fglC-3pm9A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 122
GLY A 121
ASN A  85
GLU A 547
 None
 0.99A 4fglC-3ppsA:
undetectable		 4fglC-3ppsA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sll PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		4 GLY A 111
GLY A  59
MET A  24
ASN A  25
 None
 1.23A 4fglC-3sllA:
undetectable		 4fglC-3sllA:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3te7 RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE]

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		5 GLY A 149
GLY A 150
MET A 154
ASN A 161
GLU A 193
 FAD  A 232 (-3.6A)
FAD  A 232 (-3.6A)
None
None
FAD  A 232 ( 3.1A)
 0.17A 4fglC-3te7A:
38.5		 4fglC-3te7A:
98.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgl GLUCOKINASE

(Streptomyces
griseus) 		PF00480
(ROK) 		4 GLY A 135
GLY A 136
ASN A 107
GLU A 176
 BGC  A 324 (-3.5A)
NA  A 323 (-4.1A)
NA  A 323 (-3.2A)
BGC  A 324 (-2.8A)
 1.23A 4fglC-3vglA:
undetectable		 4fglC-3vglA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vov GLUCOKINASE

(Thermus
thermophilus) 		PF00480
(ROK) 		4 GLY A 137
GLY A 138
ASN A 109
GLU A 178
 None
 1.19A 4fglC-3vovA:
undetectable		 4fglC-3vovA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpx LEUCINE
DEHYDROGENASE

(Sporosarcina
psychrophila) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 GLY A  41
MET A  65
ASN A  69
GLU A 114
 None
 1.19A 4fglC-3vpxA:
4.2		 4fglC-3vpxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrc GALLATE DIOXYGENASE

(Sphingomonas
paucimobilis) 		PF02900
(LigB)
PF07746
(LigA) 		4 GLY A 234
GLY A 233
ASN A 203
GLU A 236
 None
 1.13A 4fglC-3wrcA:
undetectable		 4fglC-3wrcA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9

(Saccharomyces
cerevisiae) 		PF03452
(Anp1) 		4 GLY A 337
GLY A 338
ASN A 236
GLU A 366
 None
None
GDP  A1395 (-3.5A)
None
 1.23A 4fglC-3zf8A:
undetectable		 4fglC-3zf8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zk6 BCL-2-LIKE PROTEIN 1

(Homo sapiens) 		PF00452
(Bcl-2)
PF02180
(BH4) 		4 GLY A 148
GLY A 147
MET A 170
GLU A  98
 None
 1.14A 4fglC-3zk6A:
undetectable		 4fglC-3zk6A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		4 GLY A 614
GLY A 626
ASN A 598
GLU A 616
 None
 1.30A 4fglC-4aioA:
undetectable		 4fglC-4aioA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfc 3-DEOXY-D-MANNO-OCTU
LOSONIC-ACID
TRANSFERASE

(Acinetobacter
baumannii) 		no annotation 4 GLY A 337
GLY A 338
ASN A 360
GLU A 335
 None
 1.16A 4fglC-4bfcA:
3.9		 4fglC-4bfcA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 GLY A 657
GLY A 654
ASN A 586
GLU A 646
 None
 1.19A 4fglC-4d8mA:
undetectable		 4fglC-4d8mA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwm PROPIONATE KINASE

(Salmonella
enterica) 		PF00871
(Acetate_kinase) 		4 GLY A  91
GLY A  90
ASN A 119
GLU A  92
 None
 1.06A 4fglC-4fwmA:
undetectable		 4fglC-4fwmA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvf BETA-HEXOSAMINIDASE

(Salmonella
enterica) 		PF00933
(Glyco_hydro_3) 		4 GLY A  28
GLY A  27
MET A   1
ASN A  55
 None
 1.23A 4fglC-4gvfA:
undetectable		 4fglC-4gvfA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyy MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG

(Homo sapiens) 		PF08423
(Rad51) 		4 GLY A 290
GLY A 289
MET A 226
ASN A 268
 None
 1.05A 4fglC-4hyyA:
undetectable		 4fglC-4hyyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyj GDSL-LIKE PROTEIN

(Bacteroides
uniformis) 		PF13472
(Lipase_GDSL_2) 		4 GLY A  78
GLY A  79
ASN A 113
GLU A  57
 None
 1.13A 4fglC-4iyjA:
3.6		 4fglC-4iyjA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2u ENOYL-COA HYDRATASE

(Rhodobacter
sphaeroides) 		PF16113
(ECH_2) 		4 GLY A 113
GLY A 112
MET A 134
GLU A  88
 None
 1.30A 4fglC-4j2uA:
undetectable		 4fglC-4j2uA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		4 GLY A 170
GLY A 171
ASN A 256
GLU A 151
 PQQ  A 602 (-3.6A)
PQQ  A 602 (-3.1A)
CE  A 601 ( 3.4A)
None
 1.26A 4fglC-4maeA:
undetectable		 4fglC-4maeA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe1 CHLOROPLAST
PENTATRICOPEPTIDE
REPEAT PROTEIN 10

(Zea mays) 		PF01535
(PPR)
PF12854
(PPR_1)
PF13041
(PPR_2)
PF13812
(PPR_3) 		4 GLY A 469
GLY A 466
ASN A 498
GLU A 436
 None
 1.30A 4fglC-4oe1A:
undetectable		 4fglC-4oe1A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozy POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		4 GLY A 114
GLY A 115
ASN A 117
GLU A 111
 None
 1.06A 4fglC-4ozyA:
undetectable		 4fglC-4ozyA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0j INTERLEUKIN-36
RECEPTOR
ANTAGONIST/INTERLEUK
IN-36 GAMMA CHIMERA
PROTEIN

(Homo sapiens) 		PF00340
(IL1) 		4 GLY A  63
GLY A  64
ASN A  84
GLU A  41
 None
 0.51A 4fglC-4p0jA:
undetectable		 4fglC-4p0jA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppy PUTATIVE
ACYLHYDROLASE

(Bacteroides
fragilis) 		PF13472
(Lipase_GDSL_2) 		4 GLY A  84
GLY A  85
ASN A 119
GLU A  63
 None
 1.14A 4fglC-4ppyA:
2.4		 4fglC-4ppyA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		4 GLY A 316
GLY A 317
ASN A 321
GLU A 259
 FAD  A 901 (-3.3A)
FAD  A 901 (-3.4A)
FAD  A 901 (-3.9A)
FAD  A 901 (-2.8A)
 1.23A 4fglC-4qi4A:
2.1		 4fglC-4qi4A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		4 GLY A 316
GLY A 317
ASN A 321
GLU A 259
 FAD  A 902 (-3.1A)
FAD  A 902 (-3.4A)
FAD  A 902 (-4.2A)
FAD  A 902 (-2.8A)
 1.21A 4fglC-4qi6A:
undetectable		 4fglC-4qi6A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi7 CELLOBIOSE
DEHYDROGENASE

(Neurospora
crassa) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		4 GLY A 316
GLY A 317
ASN A 321
GLU A 259
 FAD  A 902 (-3.6A)
FAD  A 902 (-3.3A)
FAD  A 902 (-4.2A)
FAD  A 902 (-2.5A)
 1.21A 4fglC-4qi7A:
3.1		 4fglC-4qi7A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnq BCL-2-LIKE PROTEIN 1

(Rattus
norvegicus) 		PF00452
(Bcl-2)
PF02180
(BH4) 		4 GLY A 148
GLY A 147
MET A 170
GLU A  98
 None
 1.22A 4fglC-4qnqA:
undetectable		 4fglC-4qnqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1p L-ARABINOSE
ISOMERASE

(Geobacillus
kaustophilus) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		4 GLY A 306
GLY A 308
ASN A 185
GLU A 352
 None
 1.30A 4fglC-4r1pA:
3.9		 4fglC-4r1pA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2n ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,NUCLEUS
ACCUMBENS-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF00651
(BTB) 		4 GLY A  71
GLY A  69
ASN A  66
GLU A  75
 None
 1.11A 4fglC-4u2nA:
undetectable		 4fglC-4u2nA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A  97
GLY A  98
ASN A 102
GLU A  36
 FAD  A 700 (-3.2A)
FAD  A 700 (-3.1A)
FAD  A 700 (-4.1A)
FAD  A 700 (-2.7A)
 1.30A 4fglC-4udrA:
2.3		 4fglC-4udrA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A  97
GLY A  98
ASN A 513
GLU A  36
 FAD  A 700 (-3.2A)
FAD  A 700 (-3.1A)
FAD  A 700 (-4.0A)
FAD  A 700 (-2.7A)
 1.16A 4fglC-4udrA:
2.3		 4fglC-4udrA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH

(Aquifex
aeolicus) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		4 GLY A 476
GLY A 475
MET A 425
GLU A 480
 None
 1.27A 4fglC-4z8xA:
undetectable		 4fglC-4z8xA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN

(Thauera
aromatica) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 GLY A 511
GLY A 512
ASN A 615
GLU A 510
 None
FUM  A 901 (-3.5A)
FUM  A 901 (-3.6A)
None
 1.25A 4fglC-5bwdA:
undetectable		 4fglC-5bwdA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 GLY A 783
GLY A 782
MET A 820
ASN A 823
 None
CL  A 903 ( 4.1A)
CL  A 903 ( 4.8A)
None
 0.91A 4fglC-5dllA:
undetectable		 4fglC-5dllA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 GLY A  79
GLY A  78
ASN A  98
GLU A  82
 None
 1.00A 4fglC-5dotA:
0.6		 4fglC-5dotA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0n ENOYL-COA
HYDRATASE/ISOMERASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		4 GLY X 115
GLY X  63
MET X  28
ASN X  29
 None
 1.20A 4fglC-5e0nX:
undetectable		 4fglC-5e0nX:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5emi CELL WALL
HYDROLASE/AUTOLYSIN

(Nostoc
punctiforme) 		PF01520
(Amidase_3) 		4 GLY A 459
GLY A 456
MET A 582
ASN A 588
 None
 1.17A 4fglC-5emiA:
5.0		 4fglC-5emiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4b NAD(P)H
DEHYDROGENASE
(QUINONE)

(Brucella
abortus) 		PF03358
(FMN_red) 		4 GLY A  29
GLY A  30
MET A   1
GLU A  28
 None
 1.17A 4fglC-5f4bA:
10.6		 4fglC-5f4bA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3x FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN

(Streptococcus
suis) 		PF05833
(FbpA) 		4 GLY A  21
GLY A  22
ASN A  42
GLU A  89
 None
 1.25A 4fglC-5h3xA:
undetectable		 4fglC-5h3xA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A  92
GLY A  93
ASN A  97
GLU A  38
 FAD  A 702 (-3.3A)
FAD  A 702 (-3.7A)
FAD  A 702 (-4.9A)
FAD  A 702 (-3.6A)
 1.19A 4fglC-5i68A:
undetectable		 4fglC-5i68A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 GLY A 126
GLY A 127
MET A 263
GLU A 200
 None
 1.00A 4fglC-5iq0A:
3.1		 4fglC-5iq0A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY

(Myxococcus
xanthus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 114
GLY A 119
MET A 125
GLU A 115
 None
 1.26A 4fglC-5k1sA:
3.7		 4fglC-5k1sA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5la7 HEPARANASE

(Homo sapiens) 		PF03662
(Glyco_hydro_79n) 		4 GLY A  95
GLY A  96
ASN A  64
GLU A 221
 None
6S6  A 613 (-3.2A)
None
None
 1.10A 4fglC-5la7A:
undetectable		 4fglC-5la7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		4 GLY A  43
GLY A  42
ASN A 109
GLU A  94
 None
TRS  A 604 (-4.0A)
TRS  A 604 (-3.2A)
None
 1.15A 4fglC-5m10A:
3.9		 4fglC-5m10A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN

(Arabidopsis
thaliana) 		PF00421
(PSII) 		4 GLY C 353
GLY C 352
MET C 342
GLU C 354
 None
 1.23A 4fglC-5mdxC:
undetectable		 4fglC-5mdxC:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT
POTASSIUM-TRANSPORTI
NG ATPASE KDPC
SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF03814
(KdpA)
PF02669
(KdpC) 		4 GLY C  83
GLY C  84
MET A 350
ASN C  86
 None
 1.22A 4fglC-5mrwC:
undetectable		 4fglC-5mrwC:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nck N-ACETYLMANNOSAMINE
KINASE

(Fusobacterium
nucleatum) 		PF00480
(ROK) 		4 GLY A 137
GLY A 138
ASN A 109
GLU A 168
 None
 1.21A 4fglC-5nckA:
undetectable		 4fglC-5nckA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 GLY A2201
GLY A2200
MET A2373
GLU A2205
 None
None
ATP  A4802 (-3.4A)
None
 1.31A 4fglC-5nugA:
undetectable		 4fglC-5nugA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oa3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D

(Homo sapiens) 		no annotation 4 GLY 0  67
GLY 0  68
ASN 0 181
GLU 0  46
 None
 0.90A 4fglC-5oa30:
undetectable		 4fglC-5oa30:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj3 -

(-) 		no annotation 4 GLY A 238
GLY A 239
ASN A 241
GLU A 179
 None
 1.17A 4fglC-5oj3A:
undetectable		 4fglC-5oj3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrb TRANSKETOLASE

(Neisseria
gonorrhoeae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 GLY A 410
GLY A 412
ASN A 416
GLU A 162
 None
 1.28A 4fglC-5vrbA:
3.8		 4fglC-5vrbA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvo DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		no annotation 4 GLY C 451
GLY C 452
ASN C 383
GLU C 450
 None
 1.00A 4fglC-5wvoC:
undetectable		 4fglC-5wvoC:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
LARGE SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 4 GLY C 113
GLY C 112
ASN C 623
GLU C 242
 None
 1.31A 4fglC-5y6qC:
undetectable		 4fglC-5y6qC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfp EXOCYST COMPLEX
COMPONENT SEC6

(Saccharomyces
cerevisiae) 		no annotation 4 GLY C 540
GLY C 539
ASN C 521
GLU C 543
 None
 0.98A 4fglC-5yfpC:
undetectable		 4fglC-5yfpC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys2 ENVELOPE
GLYCOPROTEIN
B,ENVELOPE
GLYCOPROTEIN B

(Suid
alphaherpesvirus
1) 		no annotation 4 GLY A 614
GLY A 613
ASN A 589
GLU A 628
 None
 1.30A 4fglC-5ys2A:
undetectable		 4fglC-5ys2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zxd -

(-) 		no annotation 4 GLY A 447
GLY A 448
ASN A  40
GLU A 401
 None
None
ATP  A 601 (-3.9A)
None
 1.04A 4fglC-5zxdA:
undetectable		 4fglC-5zxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bja ACETYL-COA
ACETYLTRANSFERASE A

(Ascaris suum) 		no annotation 4 GLY A 383
GLY A 382
MET A 159
GLU A 385
 None
CSO  A  92 ( 4.1A)
CSO  A  92 (-3.0A)
None
 1.29A 4fglC-6bjaA:
undetectable		 4fglC-6bjaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)

(Escherichia
coli) 		no annotation 4 GLY A 204
GLY A 203
ASN A 171
GLU A 188
 None
 1.05A 4fglC-6d5iA:
undetectable		 4fglC-6d5iA:
undetectable