SIMILAR PATTERNS OF AMINO ACIDS FOR 4FGL_C_CLQC303

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coy CHOLESTEROL OXIDASE

(Brevibacterium
sterolicum) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A 114
GLY A 115
ASN A 119
GLU A  41
 FAD  A 510 (-3.0A)
FAD  A 510 (-3.4A)
FAD  A 510 (-4.1A)
FAD  A 510 (-2.7A)
 1.29A 4fglC-1coyA:
2.8		 4fglC-1coyA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coy CHOLESTEROL OXIDASE

(Brevibacterium
sterolicum) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A 214
GLY A 215
MET A  59
GLU A 203
 None
None
AND  A 508 ( 4.0A)
None
 1.21A 4fglC-1coyA:
2.8		 4fglC-1coyA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		4 GLY A 508
GLY A 507
ASN A 505
GLU A 207
 None
 0.87A 4fglC-1fehA:
undetectable		 4fglC-1fehA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		4 GLY C 102
GLY C 101
ASN C  97
GLU C 106
 None
 1.16A 4fglC-1h2tC:
undetectable		 4fglC-1h2tC:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1md6 INTERLEUKIN 1
FAMILY, MEMBER 5
(DELTA)

(Mus musculus) 		PF00340
(IL1) 		4 GLY A  62
GLY A  63
ASN A  83
GLU A  40
 None
 0.80A 4fglC-1md6A:
undetectable		 4fglC-1md6A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1naa CELLOBIOSE
DEHYDROGENASE

(Phanerochaete
chrysosporium) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A 304
GLY A 305
ASN A 309
GLU A 246
 6FA  A 801 (-3.0A)
6FA  A 801 (-3.5A)
6FA  A 801 (-3.9A)
6FA  A 801 (-2.8A)
 1.23A 4fglC-1naaA:
3.1		 4fglC-1naaA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ntg TYROSYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF01588
(tRNA_bind) 		4 GLY A 166
GLY A 167
ASN A 168
GLU A 141
 None
 1.17A 4fglC-1ntgA:
undetectable		 4fglC-1ntgA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og6 HYPOTHETICAL
OXIDOREDUCTASE YDHF

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		4 GLY A 213
GLY A 215
ASN A 219
GLU A 182
 NAP  A1298 (-4.0A)
NAP  A1298 (-3.0A)
None
None
 1.18A 4fglC-1og6A:
undetectable		 4fglC-1og6A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdz ENOLASE

(Homarus
gammarus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 GLY A 155
GLY A 154
ASN A 160
GLU A 249
 None
 1.30A 4fglC-1pdzA:
undetectable		 4fglC-1pdzA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvl LEUCOCIDIN

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		4 GLY A 180
MET A 192
ASN A 190
GLU A 167
 None
 1.28A 4fglC-1pvlA:
undetectable		 4fglC-1pvlA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbl PECTATE LYASE 47

(Bacillus sp.
TS-47) 		PF00544
(Pec_lyase_C) 		4 GLY A 147
GLY A 148
MET A 127
GLU A 166
 None
 0.79A 4fglC-1vblA:
undetectable		 4fglC-1vblA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		4 GLY A  82
GLY A  81
ASN A  57
GLU A 112
 None
 1.26A 4fglC-2afbA:
4.2		 4fglC-2afbA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzw APOPTOSIS REGULATOR
BCL-X

(Mus musculus) 		PF00452
(Bcl-2)
PF02180
(BH4) 		4 GLY A 148
GLY A 147
MET A 170
GLU A  98
 None
 1.20A 4fglC-2bzwA:
undetectable		 4fglC-2bzwA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjl SECRETED CHITINASE

(Streptomyces
coelicolor) 		PF00182
(Glyco_hydro_19) 		4 GLY A 210
GLY A 211
ASN A 212
GLU A 208
 None
 1.12A 4fglC-2cjlA:
undetectable		 4fglC-2cjlA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d52 PENTAKETIDE CHROMONE
SYNTHASE

(Aloe
arborescens) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 GLY A 380
GLY A 378
MET A 365
GLU A 382
 None
 1.16A 4fglC-2d52A:
undetectable		 4fglC-2d52A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbc UNNAMED PROTEIN
PRODUCT

(Mus musculus) 		PF02114
(Phosducin) 		4 GLY A 103
GLY A 104
MET A  44
GLU A 111
 None
 1.20A 4fglC-2dbcA:
undetectable		 4fglC-2dbcA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG

(Aquifex
aeolicus) 		PF01434
(Peptidase_M41) 		4 GLY A 476
GLY A 475
MET A 425
GLU A 480
 None
 1.09A 4fglC-2di4A:
undetectable		 4fglC-2di4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpp NITRILE HYDRATASE
ALPHA SUBUNIT

(Bacillus sp.
RAPc8) 		PF02979
(NHase_alpha) 		4 GLY A 128
GLY A  59
MET A  61
ASN A  62
 None
 1.08A 4fglC-2dppA:
undetectable		 4fglC-2dppA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpw HYPOTHETICAL PROTEIN
TTHA0179

(Thermus
thermophilus) 		PF12804
(NTP_transf_3) 		4 GLY A  11
GLY A  10
ASN A  75
GLU A  13
 None
 1.31A 4fglC-2dpwA:
undetectable		 4fglC-2dpwA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		4 GLY A 153
GLY A 131
MET A 421
ASN A 424
 None
GLN  A 501 ( 4.5A)
None
None
 0.90A 4fglC-2f2aA:
undetectable		 4fglC-2f2aA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fre NAD(P)H-FLAVIN
OXIDOREDUCTASE

(Agrobacterium
fabrum) 		PF00881
(Nitroreductase) 		4 GLY A 136
GLY A 137
MET A  75
ASN A  78
 FMN  A1151 (-3.9A)
FMN  A1151 (-3.7A)
None
FMN  A1151 (-3.0A)
 1.00A 4fglC-2freA:
undetectable		 4fglC-2freA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g39 ACETYL-COA HYDROLASE

(Pseudomonas
aeruginosa) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 GLY A 372
GLY A 373
ASN A 367
GLU A 489
 None
 1.16A 4fglC-2g39A:
undetectable		 4fglC-2g39A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		4 GLY A 435
GLY A 434
MET A 533
GLU A 551
 None
None
None
CAC  A 705 ( 4.8A)
 1.11A 4fglC-2i0kA:
undetectable		 4fglC-2i0kA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iir ACETATE KINASE

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		4 GLY A  95
GLY A  94
ASN A 123
GLU A  96
 None
 1.15A 4fglC-2iirA:
undetectable		 4fglC-2iirA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k0d COLICIN-E7 IMMUNITY
PROTEIN

(Escherichia
coli) 		PF01320
(Colicin_Pyocin) 		4 GLY X  69
GLY X  70
ASN X  64
GLU X  78
 None
 1.01A 4fglC-2k0dX:
undetectable		 4fglC-2k0dX:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm1 GLUCOKINASE

(Enterococcus
faecalis) 		PF00480
(ROK) 		4 GLY A 144
GLY A 145
ASN A 116
GLU A 185
 None
MG  A1007 (-4.6A)
MG  A1007 (-2.8A)
None
 1.14A 4fglC-2qm1A:
undetectable		 4fglC-2qm1A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 GLY A  40
GLY A  76
ASN A 113
GLU A  38
 None
 1.23A 4fglC-2vw8A:
undetectable		 4fglC-2vw8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3n CARBONIC ANHYDRASE 2

(Cryptococcus
neoformans) 		PF00484
(Pro_CA) 		4 GLY A 192
MET A 112
ASN A 108
GLU A 195
 None
 0.95A 4fglC-2w3nA:
2.4		 4fglC-2w3nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze0 ALPHA-GLUCOSIDASE

(Geobacillus sp.
HTA-462) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLY A 259
MET A 229
ASN A 230
GLU A 283
 None
 1.26A 4fglC-2ze0A:
undetectable		 4fglC-2ze0A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLY A 661
GLY A 662
MET A 713
GLU A 718
 None
 0.62A 4fglC-3actA:
undetectable		 4fglC-3actA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnj CHOLESTEROL OXIDASE

(Streptomyces
sp. SA-COO) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A 114
GLY A 115
ASN A 119
GLU A  40
 FAD  A 510 (-3.0A)
FAD  A 510 (-3.4A)
FAD  A 510 (-3.9A)
FAD  A 510 (-2.7A)
 1.27A 4fglC-3cnjA:
2.2		 4fglC-3cnjA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czm L-LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A 295
GLY A 296
MET A 159
ASN A 158
 None
 1.29A 4fglC-3czmA:
5.1		 4fglC-3czmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czm L-LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A 295
GLY A 297
MET A 159
ASN A 158
 None
 1.12A 4fglC-3czmA:
5.1		 4fglC-3czmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 121
GLY A 120
ASN A  84
GLU A 542
 None
None
NAG  A 700 (-3.9A)
None
 1.01A 4fglC-3dkhA:
undetectable		 4fglC-3dkhA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		4 GLY A 411
GLY A 412
ASN A 140
GLU A 114
 CL  A 505 ( 4.0A)
None
None
ZN  A 504 ( 2.2A)
 1.30A 4fglC-3hq2A:
undetectable		 4fglC-3hq2A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iah SHORT CHAIN
DEHYDROGENASE YCIK

(Salmonella
enterica) 		PF00106
(adh_short) 		4 GLY A 197
GLY A 196
ASN A 194
GLU A 210
 NAP  A 254 (-3.3A)
NAP  A 254 (-4.6A)
None
None
 1.07A 4fglC-3iahA:
6.8		 4fglC-3iahA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ife PEPTIDASE T

(Bacillus
anthracis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLY A 201
GLY A 200
ASN A 372
GLU A 378
 None
 1.29A 4fglC-3ifeA:
2.4		 4fglC-3ifeA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		4 GLY X 354
MET X 357
ASN X 358
GLU X 877
 None
 1.15A 4fglC-3lxuX:
2.8		 4fglC-3lxuX:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdq EXOPOLYPHOSPHATASE

(Cytophaga
hutchinsonii) 		PF02541
(Ppx-GppA) 		4 GLY A 140
GLY A 139
ASN A  13
GLU A 159
 SO4  A 317 (-3.4A)
SO4  A 317 (-3.8A)
SO4  A 318 (-3.8A)
None
 1.22A 4fglC-3mdqA:
undetectable		 4fglC-3mdqA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nu1 HEMIN-BINDING
PERIPLASMIC PROTEIN

(Yersinia pestis) 		PF01497
(Peripla_BP_2) 		4 GLY A  34
GLY A  33
MET A  71
GLU A  38
 None
 1.25A 4fglC-3nu1A:
undetectable		 4fglC-3nu1A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		4 GLY A 311
GLY A 312
MET A 277
GLU A 360
 SO4  A 701 ( 3.8A)
SO4  A 701 (-4.2A)
None
None
 1.22A 4fglC-3nzqA:
undetectable		 4fglC-3nzqA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om9 LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A 295
GLY A 297
MET A 159
ASN A 158
 None
 1.12A 4fglC-3om9A:
4.6		 4fglC-3om9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm9 PUTATIVE
OXIDOREDUCTASE

(Rhodopseudomonas
palustris) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 GLY A  88
GLY A  89
ASN A 470
GLU A  42
 None
FAD  A 476 (-3.7A)
FAD  A 476 (-4.0A)
None
 1.16A 4fglC-3pm9A:
undetectable		 4fglC-3pm9A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 122
GLY A 121
ASN A  85
GLU A 547
 None
 0.99A 4fglC-3ppsA:
undetectable		 4fglC-3ppsA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sll PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		4 GLY A 111
GLY A  59
MET A  24
ASN A  25
 None
 1.23A 4fglC-3sllA:
undetectable		 4fglC-3sllA:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3te7 RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE]

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		5 GLY A 149
GLY A 150
MET A 154
ASN A 161
GLU A 193
 FAD  A 232 (-3.6A)
FAD  A 232 (-3.6A)
None
None
FAD  A 232 ( 3.1A)
 0.17A 4fglC-3te7A:
38.5		 4fglC-3te7A:
98.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgl GLUCOKINASE

(Streptomyces
griseus) 		PF00480
(ROK) 		4 GLY A 135
GLY A 136
ASN A 107
GLU A 176
 BGC  A 324 (-3.5A)
NA  A 323 (-4.1A)
NA  A 323 (-3.2A)
BGC  A 324 (-2.8A)
 1.23A 4fglC-3vglA:
undetectable		 4fglC-3vglA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vov GLUCOKINASE

(Thermus
thermophilus) 		PF00480
(ROK) 		4 GLY A 137
GLY A 138
ASN A 109
GLU A 178
 None
 1.19A 4fglC-3vovA:
undetectable		 4fglC-3vovA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpx LEUCINE
DEHYDROGENASE

(Sporosarcina
psychrophila) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 GLY A  41
MET A  65
ASN A  69
GLU A 114
 None
 1.19A 4fglC-3vpxA:
4.2		 4fglC-3vpxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrc GALLATE DIOXYGENASE

(Sphingomonas
paucimobilis) 		PF02900
(LigB)
PF07746
(LigA) 		4 GLY A 234
GLY A 233
ASN A 203
GLU A 236
 None
 1.13A 4fglC-3wrcA:
undetectable		 4fglC-3wrcA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9

(Saccharomyces
cerevisiae) 		PF03452
(Anp1) 		4 GLY A 337
GLY A 338
ASN A 236
GLU A 366
 None
None
GDP  A1395 (-3.5A)
None
 1.23A 4fglC-3zf8A:
undetectable		 4fglC-3zf8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zk6 BCL-2-LIKE PROTEIN 1

(Homo sapiens) 		PF00452
(Bcl-2)
PF02180
(BH4) 		4 GLY A 148
GLY A 147
MET A 170
GLU A  98
 None
 1.14A 4fglC-3zk6A:
undetectable		 4fglC-3zk6A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		4 GLY A 614
GLY A 626
ASN A 598
GLU A 616
 None
 1.30A 4fglC-4aioA:
undetectable		 4fglC-4aioA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfc 3-DEOXY-D-MANNO-OCTU
LOSONIC-ACID
TRANSFERASE

(Acinetobacter
baumannii) 		no annotation 4 GLY A 337
GLY A 338
ASN A 360
GLU A 335
 None
 1.16A 4fglC-4bfcA:
3.9		 4fglC-4bfcA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 GLY A 657
GLY A 654
ASN A 586
GLU A 646
 None
 1.19A 4fglC-4d8mA:
undetectable		 4fglC-4d8mA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwm PROPIONATE KINASE

(Salmonella
enterica) 		PF00871
(Acetate_kinase) 		4 GLY A  91
GLY A  90
ASN A 119
GLU A  92
 None
 1.06A 4fglC-4fwmA:
undetectable		 4fglC-4fwmA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvf BETA-HEXOSAMINIDASE

(Salmonella
enterica) 		PF00933
(Glyco_hydro_3) 		4 GLY A  28
GLY A  27
MET A   1
ASN A  55
 None
 1.23A 4fglC-4gvfA:
undetectable		 4fglC-4gvfA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyy MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG

(Homo sapiens) 		PF08423
(Rad51) 		4 GLY A 290
GLY A 289
MET A 226
ASN A 268
 None
 1.05A 4fglC-4hyyA:
undetectable		 4fglC-4hyyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyj GDSL-LIKE PROTEIN

(Bacteroides
uniformis) 		PF13472
(Lipase_GDSL_2) 		4 GLY A  78
GLY A  79
ASN A 113
GLU A  57
 None
 1.13A 4fglC-4iyjA:
3.6		 4fglC-4iyjA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2u ENOYL-COA HYDRATASE

(Rhodobacter
sphaeroides) 		PF16113
(ECH_2) 		4 GLY A 113
GLY A 112
MET A 134
GLU A  88
 None
 1.30A 4fglC-4j2uA:
undetectable		 4fglC-4j2uA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		4 GLY A 170
GLY A 171
ASN A 256
GLU A 151
 PQQ  A 602 (-3.6A)
PQQ  A 602 (-3.1A)
CE  A 601 ( 3.4A)
None
 1.26A 4fglC-4maeA:
undetectable		 4fglC-4maeA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe1 CHLOROPLAST
PENTATRICOPEPTIDE
REPEAT PROTEIN 10

(Zea mays) 		PF01535
(PPR)
PF12854
(PPR_1)
PF13041
(PPR_2)
PF13812
(PPR_3) 		4 GLY A 469
GLY A 466
ASN A 498
GLU A 436
 None
 1.30A 4fglC-4oe1A:
undetectable		 4fglC-4oe1A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozy POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		4 GLY A 114
GLY A 115
ASN A 117
GLU A 111
 None
 1.06A 4fglC-4ozyA:
undetectable		 4fglC-4ozyA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0j INTERLEUKIN-36
RECEPTOR
ANTAGONIST/INTERLEUK
IN-36 GAMMA CHIMERA
PROTEIN

(Homo sapiens) 		PF00340
(IL1) 		4 GLY A  63
GLY A  64
ASN A  84
GLU A  41
 None
 0.51A 4fglC-4p0jA:
undetectable		 4fglC-4p0jA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppy PUTATIVE
ACYLHYDROLASE

(Bacteroides
fragilis) 		PF13472
(Lipase_GDSL_2) 		4 GLY A  84
GLY A  85
ASN A 119
GLU A  63
 None
 1.14A 4fglC-4ppyA:
2.4		 4fglC-4ppyA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		4 GLY A 316
GLY A 317
ASN A 321
GLU A 259
 FAD  A 901 (-3.3A)
FAD  A 901 (-3.4A)
FAD  A 901 (-3.9A)
FAD  A 901 (-2.8A)
 1.23A 4fglC-4qi4A:
2.1		 4fglC-4qi4A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		4 GLY A 316
GLY A 317
ASN A 321
GLU A 259
 FAD  A 902 (-3.1A)
FAD  A 902 (-3.4A)
FAD  A 902 (-4.2A)
FAD  A 902 (-2.8A)
 1.21A 4fglC-4qi6A:
undetectable		 4fglC-4qi6A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi7 CELLOBIOSE
DEHYDROGENASE

(Neurospora
crassa) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		4 GLY A 316
GLY A 317
ASN A 321
GLU A 259
 FAD  A 902 (-3.6A)
FAD  A 902 (-3.3A)
FAD  A 902 (-4.2A)
FAD  A 902 (-2.5A)
 1.21A 4fglC-4qi7A:
3.1		 4fglC-4qi7A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnq BCL-2-LIKE PROTEIN 1

(Rattus
norvegicus) 		PF00452
(Bcl-2)
PF02180
(BH4) 		4 GLY A 148
GLY A 147
MET A 170
GLU A  98
 None
 1.22A 4fglC-4qnqA:
undetectable		 4fglC-4qnqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1p L-ARABINOSE
ISOMERASE

(Geobacillus
kaustophilus) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		4 GLY A 306
GLY A 308
ASN A 185
GLU A 352
 None
 1.30A 4fglC-4r1pA:
3.9		 4fglC-4r1pA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2n ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,NUCLEUS
ACCUMBENS-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF00651
(BTB) 		4 GLY A  71
GLY A  69
ASN A  66
GLU A  75
 None
 1.11A 4fglC-4u2nA:
undetectable		 4fglC-4u2nA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A  97
GLY A  98
ASN A 102
GLU A  36
 FAD  A 700 (-3.2A)
FAD  A 700 (-3.1A)
FAD  A 700 (-4.1A)
FAD  A 700 (-2.7A)
 1.30A 4fglC-4udrA:
2.3		 4fglC-4udrA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A  97
GLY A  98
ASN A 513
GLU A  36
 FAD  A 700 (-3.2A)
FAD  A 700 (-3.1A)
FAD  A 700 (-4.0A)
FAD  A 700 (-2.7A)
 1.16A 4fglC-4udrA:
2.3		 4fglC-4udrA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH

(Aquifex
aeolicus) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		4 GLY A 476
GLY A 475
MET A 425
GLU A 480
 None
 1.27A 4fglC-4z8xA:
undetectable		 4fglC-4z8xA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN

(Thauera
aromatica) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 GLY A 511
GLY A 512
ASN A 615
GLU A 510
 None
FUM  A 901 (-3.5A)
FUM  A 901 (-3.6A)
None
 1.25A 4fglC-5bwdA:
undetectable		 4fglC-5bwdA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 GLY A 783
GLY A 782
MET A 820
ASN A 823
 None
CL  A 903 ( 4.1A)
CL  A 903 ( 4.8A)
None
 0.91A 4fglC-5dllA:
undetectable		 4fglC-5dllA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 GLY A  79
GLY A  78
ASN A  98
GLU A  82
 None
 1.00A 4fglC-5dotA:
0.6		 4fglC-5dotA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0n ENOYL-COA
HYDRATASE/ISOMERASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		4 GLY X 115
GLY X  63
MET X  28
ASN X  29
 None
 1.20A 4fglC-5e0nX:
undetectable		 4fglC-5e0nX:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5emi CELL WALL
HYDROLASE/AUTOLYSIN

(Nostoc
punctiforme) 		PF01520
(Amidase_3) 		4 GLY A 459
GLY A 456
MET A 582
ASN A 588
 None
 1.17A 4fglC-5emiA:
5.0		 4fglC-5emiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4b NAD(P)H
DEHYDROGENASE
(QUINONE)

(Brucella
abortus) 		PF03358
(FMN_red) 		4 GLY A  29
GLY A  30
MET A   1
GLU A  28
 None
 1.17A 4fglC-5f4bA:
10.6		 4fglC-5f4bA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3x FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN

(Streptococcus
suis) 		PF05833
(FbpA) 		4 GLY A  21
GLY A  22
ASN A  42
GLU A  89
 None
 1.25A 4fglC-5h3xA:
undetectable		 4fglC-5h3xA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A  92
GLY A  93
ASN A  97
GLU A  38
 FAD  A 702 (-3.3A)
FAD  A 702 (-3.7A)
FAD  A 702 (-4.9A)
FAD  A 702 (-3.6A)
 1.19A 4fglC-5i68A:
undetectable		 4fglC-5i68A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 GLY A 126
GLY A 127
MET A 263
GLU A 200
 None
 1.00A 4fglC-5iq0A:
3.1		 4fglC-5iq0A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY

(Myxococcus
xanthus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 114
GLY A 119
MET A 125
GLU A 115
 None
 1.26A 4fglC-5k1sA:
3.7		 4fglC-5k1sA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5la7 HEPARANASE

(Homo sapiens) 		PF03662
(Glyco_hydro_79n) 		4 GLY A  95
GLY A  96
ASN A  64
GLU A 221
 None
6S6  A 613 (-3.2A)
None
None
 1.10A 4fglC-5la7A:
undetectable		 4fglC-5la7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		4 GLY A  43
GLY A  42
ASN A 109
GLU A  94
 None
TRS  A 604 (-4.0A)
TRS  A 604 (-3.2A)
None
 1.15A 4fglC-5m10A:
3.9		 4fglC-5m10A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN

(Arabidopsis
thaliana) 		PF00421
(PSII) 		4 GLY C 353
GLY C 352
MET C 342
GLU C 354
 None
 1.23A 4fglC-5mdxC:
undetectable		 4fglC-5mdxC:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT
POTASSIUM-TRANSPORTI
NG ATPASE KDPC
SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF03814
(KdpA)
PF02669
(KdpC) 		4 GLY C  83
GLY C  84
MET A 350
ASN C  86
 None
 1.22A 4fglC-5mrwC:
undetectable		 4fglC-5mrwC:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nck N-ACETYLMANNOSAMINE
KINASE

(Fusobacterium
nucleatum) 		PF00480
(ROK) 		4 GLY A 137
GLY A 138
ASN A 109
GLU A 168
 None
 1.21A 4fglC-5nckA:
undetectable		 4fglC-5nckA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 GLY A2201
GLY A2200
MET A2373
GLU A2205
 None
None
ATP  A4802 (-3.4A)
None
 1.31A 4fglC-5nugA:
undetectable		 4fglC-5nugA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oa3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D

(Homo sapiens) 		no annotation 4 GLY 0  67
GLY 0  68
ASN 0 181
GLU 0  46
 None
 0.90A 4fglC-5oa30:
undetectable		 4fglC-5oa30:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj3 -

(-) 		no annotation 4 GLY A 238
GLY A 239
ASN A 241
GLU A 179
 None
 1.17A 4fglC-5oj3A:
undetectable		 4fglC-5oj3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrb TRANSKETOLASE

(Neisseria
gonorrhoeae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 GLY A 410
GLY A 412
ASN A 416
GLU A 162
 None
 1.28A 4fglC-5vrbA:
3.8		 4fglC-5vrbA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvo DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		no annotation 4 GLY C 451
GLY C 452
ASN C 383
GLU C 450
 None
 1.00A 4fglC-5wvoC:
undetectable		 4fglC-5wvoC:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
LARGE SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 4 GLY C 113
GLY C 112
ASN C 623
GLU C 242
 None
 1.31A 4fglC-5y6qC:
undetectable		 4fglC-5y6qC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfp EXOCYST COMPLEX
COMPONENT SEC6

(Saccharomyces
cerevisiae) 		no annotation 4 GLY C 540
GLY C 539
ASN C 521
GLU C 543
 None
 0.98A 4fglC-5yfpC:
undetectable		 4fglC-5yfpC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys2 ENVELOPE
GLYCOPROTEIN
B,ENVELOPE
GLYCOPROTEIN B

(Suid
alphaherpesvirus
1) 		no annotation 4 GLY A 614
GLY A 613
ASN A 589
GLU A 628
 None
 1.30A 4fglC-5ys2A:
undetectable		 4fglC-5ys2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zxd -

(-) 		no annotation 4 GLY A 447
GLY A 448
ASN A  40
GLU A 401
 None
None
ATP  A 601 (-3.9A)
None
 1.04A 4fglC-5zxdA:
undetectable		 4fglC-5zxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bja ACETYL-COA
ACETYLTRANSFERASE A

(Ascaris suum) 		no annotation 4 GLY A 383
GLY A 382
MET A 159
GLU A 385
 None
CSO  A  92 ( 4.1A)
CSO  A  92 (-3.0A)
None
 1.29A 4fglC-6bjaA:
undetectable		 4fglC-6bjaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)

(Escherichia
coli) 		no annotation 4 GLY A 204
GLY A 203
ASN A 171
GLU A 188
 None
 1.05A 4fglC-6d5iA:
undetectable		 4fglC-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqg D-GLUCARATE
DEHYDRATASE

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A  57
VAL A  56
HIS A  55
GLN A 132
 None
 0.83A 4fglD-1bqgA:
0.4		 4fglD-1bqgA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri) 		PF00089
(Trypsin) 		4 GLY A  44
VAL A  31
PHE A 209
ILE A  47
 None
 0.68A 4fglD-1bqyA:
undetectable		 4fglD-1bqyA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 GLY A 908
VAL A 787
HIS A 788
PHE A 367
 None
K  A4009 ( 4.4A)
ADP  A4006 (-4.2A)
None
 0.97A 4fglD-1c30A:
3.4		 4fglD-1c30A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ASN A  49
GLY A  51
PHE A  79
ILE A  83
 None
 0.94A 4fglD-1i2dA:
3.0		 4fglD-1i2dA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j93 UROPORPHYRINOGEN
DECARBOXYLASE

(Nicotiana
tabacum) 		PF01208
(URO-D) 		4 GLY A 164
VAL A 103
ILE A  92
PHE A 190
 None
 0.80A 4fglD-1j93A:
undetectable		 4fglD-1j93A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		4 ASN A 646
GLY A  26
VAL A  27
ILE A  20
 None
 0.95A 4fglD-1kehA:
undetectable		 4fglD-1kehA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kj9 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE 2

(Escherichia
coli) 		PF02222
(ATP-grasp) 		4 GLY A 196
VAL A 197
ILE A 168
PHE A 141
 EDO  A 402 ( 3.2A)
ATP  A   1 (-3.9A)
None
None
 0.82A 4fglD-1kj9A:
2.9		 4fglD-1kj9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE

(Klebsiella sp.
LX3) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLY A 593
VAL A 594
ILE A 395
PHE A 551
 None
 0.91A 4fglD-1m53A:
0.0		 4fglD-1m53A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1op2 VENOM SERINE
PROTEINASE

(Deinagkistrodon
acutus) 		PF00089
(Trypsin) 		4 GLY A  44
VAL A  31
PHE A 209
ILE A  47
 None
 0.72A 4fglD-1op2A:
undetectable		 4fglD-1op2A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s8e EXONUCLEASE PUTATIVE

(Pyrococcus
furiosus) 		PF00149
(Metallophos) 		4 GLY A 142
HIS A 141
ILE A 169
PHE A  43
 None
 0.92A 4fglD-1s8eA:
undetectable		 4fglD-1s8eA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1scm MYOSIN ESSENTIAL
LIGHT CHAIN

(Argopecten
irradians) 		PF13499
(EF-hand_7) 		4 GLY C  53
VAL C  52
PHE C  68
PHE C  15
 None
 0.94A 4fglD-1scmC:
undetectable		 4fglD-1scmC:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tw9 GLUTATHIONE
S-TRANSFERASE 2

(Heligmosomoides
polygyrus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ASN A 143
GLY A 146
HIS A 184
ILE A 153
 None
 0.94A 4fglD-1tw9A:
undetectable		 4fglD-1tw9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tye INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 GLY B 221
PHE B 248
ILE B 226
PHE B 308
 None
 0.80A 4fglD-1tyeB:
3.2		 4fglD-1tyeB:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		4 GLY A 132
VAL A 133
PHE A 144
ILE A 111
 None
 0.86A 4fglD-1vclA:
undetectable		 4fglD-1vclA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmo VITELLINE MEMBRANE
OUTER LAYER PROTEIN
I

(Gallus gallus) 		PF03762
(VOMI) 		4 GLY A 120
PHE A  34
ILE A  53
PHE A 108
 None
 0.87A 4fglD-1vmoA:
undetectable		 4fglD-1vmoA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3t HYPOTHETICAL PROTEIN
YXAG

(Bacillus
subtilis) 		PF07883
(Cupin_2) 		4 GLY A 288
VAL A 289
PHE A 299
ILE A 207
 None
 0.94A 4fglD-1y3tA:
undetectable		 4fglD-1y3tA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc4 RAS-RELATED PROTEIN
RAL-A

(Homo sapiens) 		PF00071
(Ras) 		4 GLY A  21
VAL A  92
PHE A  83
ILE A  18
 None
 0.79A 4fglD-1zc4A:
4.6		 4fglD-1zc4A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00155
(Aminotran_1_2) 		4 GLY A 408
VAL A 407
PHE A 350
PHE A 352
 None
 0.77A 4fglD-2ay9A:
2.8		 4fglD-2ay9A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkk BASEPLATE STRUCTURAL
PROTEIN GP10

(Escherichia
virus T4) 		no annotation 4 ASN A 502
GLY A 517
PHE A 481
ILE A 428
 None
 0.79A 4fglD-2fkkA:
undetectable		 4fglD-2fkkA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Aquifex
aeolicus) 		PF00308
(Bac_DnaA)
PF08299
(Bac_DnaA_C) 		4 ASN A 113
PHE A 195
ILE A 198
PHE A 151
 None
 0.90A 4fglD-2hcbA:
undetectable		 4fglD-2hcbA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU

(Streptococcus
pneumoniae) 		PF01895
(PhoU) 		4 VAL A 205
PHE A 137
ILE A 200
PHE A  16
 None
 0.84A 4fglD-2i0mA:
undetectable		 4fglD-2i0mA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu5 HTH-TYPE DHAKLM
OPERON
TRANSCRIPTIONAL
ACTIVATOR DHAS

(Lactococcus
lactis) 		PF00440
(TetR_N) 		4 ASN A  67
GLN A 110
PHE A 106
ILE A 109
 None
 0.86A 4fglD-2iu5A:
undetectable		 4fglD-2iu5A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8s AGR_C_984P

(Agrobacterium
fabrum) 		PF06748
(DUF1217) 		4 ASN A 193
GLY A 195
VAL A 196
ILE A 271
 None
 0.75A 4fglD-2o8sA:
undetectable		 4fglD-2o8sA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odr PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanococcus
maripaludis) 		PF01409
(tRNA-synt_2d) 		4 GLY B 190
GLN B  81
PHE B  82
ILE B  78
 None
 0.82A 4fglD-2odrB:
undetectable		 4fglD-2odrB:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06471
(NSP11) 		4 GLY A 253
PHE A 240
ILE A 295
PHE A 329
 None
 0.95A 4fglD-2ozkA:
undetectable		 4fglD-2ozkA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p24 H-2 CLASS II
HISTOCOMPATIBILITY
ANTIGEN, A-U ALPHA
CHAIN

(Mus musculus) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 GLY A   7
VAL A   6
HIS A   5
PHE A  48
 None
 0.82A 4fglD-2p24A:
undetectable		 4fglD-2p24A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3v INOSITOL-1-MONOPHOSP
HATASE

(Thermotoga
maritima) 		PF00459
(Inositol_P) 		4 GLY A1015
VAL A1014
PHE A1094
ILE A1081
 None
 0.96A 4fglD-2p3vA:
2.1		 4fglD-2p3vA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3y VIRULENCE FACTOR

(Pectobacterium
carotovorum) 		no annotation 4 GLY A 152
PHE A 198
ILE A 205
PHE A 219
 PLM  A1278 ( 4.2A)
None
None
PLM  A1278 ( 3.7A)
 0.95A 4fglD-2w3yA:
undetectable		 4fglD-2w3yA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		4 ASN A 280
GLY A 560
VAL A 561
PHE A 582
 None
 0.93A 4fglD-2w92A:
undetectable		 4fglD-2w92A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anx SPERMIDINE SYNTHASE

(Thermus
thermophilus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 VAL A  53
PHE A 234
ILE A 227
PHE A 236
 None
 0.86A 4fglD-3anxA:
2.6		 4fglD-3anxA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A  82
VAL A  74
ILE A  71
PHE A 374
 None
 0.81A 4fglD-3bjsA:
undetectable		 4fglD-3bjsA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce1 SUPEROXIDE DISMUTASE
[CU-ZN]

(Naganishia
liquefaciens) 		PF00080
(Sod_Cu) 		4 GLY A 151
VAL A 152
PHE A  23
ILE A 116
 None
 0.87A 4fglD-3ce1A:
undetectable		 4fglD-3ce1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Enterococcus
faecalis) 		PF13377
(Peripla_BP_3) 		4 GLY A  63
VAL A  64
PHE A 127
ILE A 134
 None
 0.87A 4fglD-3cs3A:
undetectable		 4fglD-3cs3A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5n Q97W15_SULSO

(Sulfolobus
solfataricus) 		PF12804
(NTP_transf_3) 		4 GLY A   4
VAL A   5
PHE A 138
ILE A 133
 None
 0.89A 4fglD-3d5nA:
undetectable		 4fglD-3d5nA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fna POSSIBLE ARABINOSE
5-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00571
(CBS) 		4 GLY A 322
VAL A 323
HIS A 218
ILE A 216
 None
 0.87A 4fglD-3fnaA:
undetectable		 4fglD-3fnaA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		4 ASN A 280
GLY A 560
VAL A 561
PHE A 582
 None
 0.94A 4fglD-3gdbA:
undetectable		 4fglD-3gdbA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hig AMILORIDE-SENSITIVE
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 GLY A 524
PHE A 701
ILE A 346
PHE A 702
 None
 0.93A 4fglD-3higA:
undetectable		 4fglD-3higA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 4 ASN A 227
GLY A 226
VAL A 225
HIS A 224
 None
 0.96A 4fglD-3j3iA:
undetectable		 4fglD-3j3iA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1l FANCL

(Drosophila
melanogaster) 		no annotation 4 VAL B 341
HIS B 339
ILE B 313
PHE B 366
 None
ZN  B 383 (-2.7A)
None
None
 0.96A 4fglD-3k1lB:
undetectable		 4fglD-3k1lB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4w UNCHARACTERIZED
PROTEIN BB4693

(Bordetella
bronchiseptica) 		PF04909
(Amidohydro_2) 		4 ASN A 121
GLY A  66
VAL A  65
ILE A  20
 None
 0.89A 4fglD-3k4wA:
undetectable		 4fglD-3k4wA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 GLY A 405
VAL A 404
HIS A 401
ILE A 379
 None
 0.89A 4fglD-3kbhA:
undetectable		 4fglD-3kbhA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxp PRETHROMBIN-1

(Homo sapiens) 		PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light) 		4 ASN A 221
GLY A 224
PHE A 280
PHE A 281
 None
 0.84A 4fglD-3nxpA:
undetectable		 4fglD-3nxpA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojl CAP5O

(Staphylococcus
aureus) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 GLY A 171
VAL A 147
HIS A 148
ILE A 168
 None
 0.93A 4fglD-3ojlA:
4.8		 4fglD-3ojlA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqb OXIDOREDUCTASE

(Bradyrhizobium
diazoefficiens) 		PF01408
(GFO_IDH_MocA) 		4 GLY A  13
VAL A  14
PHE A  87
ILE A  10
 None
 0.88A 4fglD-3oqbA:
4.0		 4fglD-3oqbA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s69 THROMBIN-LIKE ENZYME
DEFIBRASE

(Gloydius
saxatilis) 		PF00089
(Trypsin) 		4 GLY A  43
VAL A  31
PHE A 205
ILE A  46
 None
 0.74A 4fglD-3s69A:
undetectable		 4fglD-3s69A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6p CAPSID PROTEIN

(Helicoverpa
armigera stunt
virus) 		PF03566
(Peptidase_A21) 		4 GLY A 265
HIS A 513
PHE A 514
ILE A 157
 None
 0.94A 4fglD-3s6pA:
undetectable		 4fglD-3s6pA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 ASN A 542
GLY A 541
ILE A 517
PHE A 568
 None
 0.90A 4fglD-3syjA:
undetectable		 4fglD-3syjA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 GLY A 549
VAL A 550
ILE A 501
PHE A 473
 None
 0.91A 4fglD-3szeA:
undetectable		 4fglD-3szeA:
12.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3te7 RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE]

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		8 ASN A  66
GLY A  68
VAL A  69
HIS A  72
GLN A 122
PHE A 126
ILE A 128
PHE A 178
 None
TE7  A   1 ( 4.1A)
None
None
TE7  A   1 ( 4.3A)
TE7  A   1 (-4.3A)
None
TE7  A   1 (-3.6A)
 0.53A 4fglD-3te7A:
38.9		 4fglD-3te7A:
98.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0o SELENIDE, WATER
DIKINASE

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ASN A 277
GLY A 232
GLN A 300
ILE A 182
 None
 0.95A 4fglD-3u0oA:
undetectable		 4fglD-3u0oA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00155
(Aminotran_1_2) 		4 GLY A 209
HIS A 217
GLN A 213
PHE A  92
 None
 0.90A 4fglD-3wy7A:
undetectable		 4fglD-3wy7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00155
(Aminotran_1_2) 		4 GLY A 214
HIS A 217
GLN A 213
PHE A  92
 None
 0.93A 4fglD-3wy7A:
undetectable		 4fglD-3wy7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PDX2 PROTEIN

(Plasmodium
falciparum) 		PF01174
(SNO) 		4 GLY G   7
VAL G   8
PHE G  75
ILE G  83
 None
 0.86A 4fglD-4adsG:
4.3		 4fglD-4adsG:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgv MALATE DEHYDROGENASE

(Picrophilus
torridus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A 109
VAL A 108
PHE A 320
ILE A 102
 None
 0.77A 4fglD-4bgvA:
5.0		 4fglD-4bgvA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi5 TRIOSEPHOSPHATE
ISOMERASE

(Giardia
intestinalis) 		PF00121
(TIM) 		4 GLY A 192
VAL A 189
HIS A 190
ILE A 167
 None
 0.79A 4fglD-4bi5A:
undetectable		 4fglD-4bi5A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		4 GLY B 221
PHE B 248
ILE B 226
PHE B 308
 None
 0.82A 4fglD-4cakB:
undetectable		 4fglD-4cakB:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 GLY A 366
HIS A 376
ILE A 338
PHE A 395
 None
 0.74A 4fglD-4cvqA:
undetectable		 4fglD-4cvqA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A  94
VAL A  95
HIS A 126
PHE A  50
 None
 0.97A 4fglD-4f7kA:
undetectable		 4fglD-4f7kA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwm PROPIONATE KINASE

(Salmonella
enterica) 		PF00871
(Acetate_kinase) 		4 GLY A 343
VAL A 344
ILE A 308
PHE A 323
 None
 0.95A 4fglD-4fwmA:
undetectable		 4fglD-4fwmA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1k TRIOSEPHOSPHATE
ISOMERASE

(Burkholderia
thailandensis) 		PF00121
(TIM) 		4 GLY A  43
VAL A  44
ILE A 233
PHE A 223
 None
 0.84A 4fglD-4g1kA:
undetectable		 4fglD-4g1kA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Flavobacterium
johnsoniae) 		PF01884
(PcrB) 		4 GLY A 208
VAL A 207
ILE A 217
PHE A 240
 1GP  A 301 (-3.4A)
None
None
None
 0.86A 4fglD-4jejA:
undetectable		 4fglD-4jejA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo8 M157

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 GLY A 170
GLN A 102
PHE A  98
ILE A 101
 None
 0.72A 4fglD-4jo8A:
undetectable		 4fglD-4jo8A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2

(Homo sapiens;
Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF17205
(PSI_integrin) 		4 GLY A 412
PHE B 247
ILE A 435
PHE B 245
 None
 0.82A 4fglD-4nenA:
4.3		 4fglD-4nenA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A 347
VAL A 348
PHE A 410
ILE A 354
 None
 0.85A 4fglD-4qavA:
undetectable		 4fglD-4qavA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv3 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE

(Staphylococcus
aureus) 		PF00388
(PI-PLC-X) 		4 GLY A  60
PHE A  64
ILE A 108
PHE A  92
 None
 0.88A 4fglD-4rv3A:
undetectable		 4fglD-4rv3A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 GLY B 224
PHE B 251
ILE B 229
PHE B 311
 None
 0.63A 4fglD-4um8B:
3.8		 4fglD-4um8B:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		4 ASN A 141
GLY A 142
PHE A 129
ILE A 215
 None
 0.97A 4fglD-4v20A:
undetectable		 4fglD-4v20A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrw URACIL-DNA
GLYCOSYLASE

(Mycobacterium
tuberculosis) 		PF03167
(UDG) 		4 ASN A 127
GLY A  66
ILE A  97
PHE A 207
 GOL  A 307 (-2.8A)
GOL  A 307 (-3.5A)
None
None
 0.89A 4fglD-4wrwA:
undetectable		 4fglD-4wrwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yah D-METHIONINE-BINDING
LIPOPROTEIN METQ

(Escherichia
coli) 		PF03180
(Lipoprotein_9) 		4 GLY X  36
VAL X  64
PHE X 246
ILE X  33
 None
 0.96A 4fglD-4yahX:
undetectable		 4fglD-4yahX:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
aeruginosa) 		PF00275
(EPSP_synthase) 		4 ASN A 317
GLY A 324
VAL A 357
ILE A 327
 None
 0.96A 4fglD-5bq2A:
undetectable		 4fglD-5bq2A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwi GLYCOSIDE HYDROLASE
FAMILY 79

(Burkholderia
pseudomallei) 		PF12891
(Glyco_hydro_44) 		4 GLY A 287
PHE A  30
ILE A  26
PHE A 327
 None
 0.95A 4fglD-5bwiA:
undetectable		 4fglD-5bwiA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlb CHAPERONE ESPG3

(Mycobacterium
marinum) 		PF14011
(ESX-1_EspG) 		4 GLY A  64
VAL A  65
PHE A  17
PHE A  47
 None
 0.94A 4fglD-5dlbA:
undetectable		 4fglD-5dlbA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L
INTEGRIN BETA-2

(Homo sapiens;
Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 GLY A 406
PHE B 247
ILE A 431
PHE B 245
 None
 0.90A 4fglD-5e6sA:
5.7		 4fglD-5e6sA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Homo sapiens) 		PF01652
(IF4E) 		4 ASN A 213
GLY A 196
VAL A 216
ILE A 193
 None
 0.88A 4fglD-5ei3A:
undetectable		 4fglD-5ei3A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP4

(Saccharomyces
cerevisiae) 		PF14382
(ECR1_N)
PF15985
(KH_6) 		4 ASN H 228
GLY H 226
VAL H 112
HIS H 111
 None
 0.78A 4fglD-5g06H:
undetectable		 4fglD-5g06H:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 GLY A1931
VAL A1932
PHE A2022
ILE A2026
 None
 0.94A 4fglD-5i6gA:
undetectable		 4fglD-5i6gA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 GLY A1931
VAL A1932
PHE A2022
ILE A2026
 None
 0.92A 4fglD-5i6iA:
undetectable		 4fglD-5i6iA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihw SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN E

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		4 ASN A 533
GLY A 470
PHE A 438
ILE A 564
 None
 0.96A 4fglD-5ihwA:
undetectable		 4fglD-5ihwA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES

(Corynebacterium
glutamicum) 		PF00933
(Glyco_hydro_3) 		4 GLY A 178
VAL A 179
PHE A 127
ILE A  98
 None
 0.71A 4fglD-5iobA:
undetectable		 4fglD-5iobA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9n POLYAMINE N
ACETYLTRANSFERASE

(Drosophila
melanogaster) 		PF00583
(Acetyltransf_1) 		4 GLY A 132
VAL A 133
HIS A  29
ILE A  71
 None
 0.69A 4fglD-5k9nA:
undetectable		 4fglD-5k9nA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kia L-THREONINE
3-DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 114
VAL A 113
HIS A  63
PHE A 325
 None
 0.94A 4fglD-5kiaA:
3.5		 4fglD-5kiaA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA

(Mus musculus) 		PF01532
(Glyco_hydro_47) 		4 ASN A 394
GLY A 414
ILE A 461
PHE A 484
 None
 0.64A 4fglD-5kkbA:
undetectable		 4fglD-5kkbA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kl0 PHOSPHOGLUCOMUTASE

(Xanthomonas
citri) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 GLY A 358
HIS A 347
PHE A 267
PHE A 254
 None
 0.93A 4fglD-5kl0A:
undetectable		 4fglD-5kl0A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn7 URACIL-DNA
GLYCOSYLASE

(Human
gammaherpesvirus
8) 		no annotation 4 GLY A 141
VAL A 142
ILE A 175
PHE A  34
 None
 0.95A 4fglD-5nn7A:
undetectable		 4fglD-5nn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oge GDP-MANNOSE
TRANSPORTER 1

(Saccharomyces
cerevisiae) 		no annotation 4 ASN A 288
GLY A 285
VAL A 284
PHE A 198
 None
 0.93A 4fglD-5ogeA:
undetectable		 4fglD-5ogeA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN

(Bos taurus) 		PF00654
(Voltage_CLC) 		4 ASN A 509
GLY A 476
PHE A 426
PHE A 213
 None
 0.94A 4fglD-5tr1A:
undetectable		 4fglD-5tr1A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0a GLUCANASE

(Trichoderma
harzianum) 		no annotation 4 ASN A 142
GLY A 143
PHE A 130
ILE A 199
 ASN  A 142 ( 0.6A)
GLY  A 143 ( 0.0A)
PHE  A 130 ( 1.3A)
ILE  A 199 ( 0.7A)
 0.93A 4fglD-5w0aA:
undetectable		 4fglD-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3w ARYLDIALKYLPHOSPHATA
SE

(Sulfolobus
solfataricus) 		no annotation 4 ASN A 236
PHE A 305
ILE A 301
PHE A  18
 None
 0.93A 4fglD-5w3wA:
undetectable		 4fglD-5w3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo sapiens) 		no annotation 4 GLY A1558
VAL A1557
GLN A1573
ILE A1572
 None
 0.87A 4fglD-5wchA:
undetectable		 4fglD-5wchA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		4 GLY A 166
PHE A 262
ILE A 189
PHE A 206
 None
 0.90A 4fglD-5x2qA:
4.5		 4fglD-5x2qA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE ALPHA
SUBUNIT

(Diaphorobacter
sp. DS2) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 GLY A 296
VAL A 201
ILE A 204
PHE A 222
 None
 0.93A 4fglD-5xbpA:
undetectable		 4fglD-5xbpA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y83 MEMBRANE PROTEIN
INSERTASE YIDC

(Thermotoga
maritima) 		no annotation 4 GLY A  91
VAL A  92
ILE A 118
PHE A  44
 None
 0.94A 4fglD-5y83A:
undetectable		 4fglD-5y83A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zhz PROBABLE
ENDONUCLEASE 4

(Mycobacterium
tuberculosis) 		no annotation 4 ASN A 193
HIS A   6
GLN A  25
ILE A  94
 ZN  A 305 ( 4.9A)
None
None
None
 0.78A 4fglD-5zhzA:
undetectable		 4fglD-5zhzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zi9 CYTOKININ RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE

(Streptomyces
coelicolor) 		no annotation 4 ASN A 144
GLY A 111
PHE A 163
ILE A 108
 None
 0.89A 4fglD-5zi9A:
5.3		 4fglD-5zi9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT F

(Flavobacterium
johnsoniae) 		no annotation 4 GLN F 131
PHE F 127
ILE F 130
PHE F 287
 None
 0.80A 4fglD-6btmF:
undetectable		 4fglD-6btmF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4

(Homo sapiens) 		no annotation 4 GLY A 263
VAL A 264
ILE A 270
PHE A 281
 None
 0.92A 4fglD-6c90A:
undetectable		 4fglD-6c90A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
putida) 		no annotation 4 ASN A 317
GLY A 324
VAL A 357
ILE A 327
 None
 0.90A 4fglD-6cn1A:
undetectable		 4fglD-6cn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
COMPONENT RRP40

(Homo sapiens) 		no annotation 4 ASN G 234
GLY G 232
VAL G 117
ILE G 193
 None
 0.89A 4fglD-6d6qG:
undetectable		 4fglD-6d6qG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME RNA HELICASE
MTR4

(Homo sapiens) 		no annotation 4 GLY M 263
VAL M 264
ILE M 270
PHE M 281
 None
 0.70A 4fglD-6d6qM:
undetectable		 4fglD-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gii CYTOCHROME P450

(Tepidiphilus
thermophilus) 		no annotation 4 GLY A 219
VAL A 220
ILE A 305
PHE A 170
 None
None
HEM  A 501 ( 4.4A)
HEM  A 501 ( 4.2A)
 0.91A 4fglD-6giiA:
undetectable		 4fglD-6giiA:
undetectable