SIMILAR PATTERNS OF AMINO ACIDS FOR 4FGK_A_0TXA302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7g TYROSINE
PHENOL-LYASE

(Pantoea
agglomerans) 		PF01212
(Beta_elim_lyase) 		4 GLN A 364
PHE A 453
PRO A 362
PHE A 439
 None
 1.20A 4fgkA-1c7gA:
2.7		 4fgkA-1c7gA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3e ALCOHOL
DEHYDROGENASE, CLASS
II

(Mus musculus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A  90
PRO A  91
PHE A  92
PHE A 321
 None
 0.94A 4fgkA-1e3eA:
4.0		 4fgkA-1e3eA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5p APHRODISIN

(Mesocricetus
auratus) 		PF00061
(Lipocalin) 		4 PHE A  93
ILE A  87
PRO A  84
PHE A 129
 None
 1.24A 4fgkA-1e5pA:
undetectable		 4fgkA-1e5pA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3g GLUCOSE-SPECIFIC
PHOSPHOCARRIER
PROTEIN IIAGLC

(Escherichia
coli) 		PF00358
(PTS_EIIA_1) 		4 PHE A  91
ILE A  52
PRO A  25
PHE A 122
 None
 1.25A 4fgkA-1f3gA:
undetectable		 4fgkA-1f3gA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE

(Rattus
norvegicus) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		4 ILE A 200
PRO A 236
PHE A 234
PHE A 232
 None
 1.13A 4fgkA-1gjvA:
undetectable		 4fgkA-1gjvA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE

(Escherichia
coli) 		PF13406
(SLT_2) 		4 GLN A  61
ILE A  64
PHE A  63
PHE A 183
 None
 1.18A 4fgkA-1ltmA:
undetectable		 4fgkA-1ltmA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n97 CYP175A1

(Thermus
thermophilus) 		PF00067
(p450) 		4 GLN A 244
PHE A 354
PHE A 357
PHE A 353
 None
 1.23A 4fgkA-1n97A:
undetectable		 4fgkA-1n97A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		4 GLN A   4
ILE A   6
PHE A 284
PHE A 290
 None
 0.98A 4fgkA-1oltA:
undetectable		 4fgkA-1oltA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc6 HYPOTHETICAL PROTEIN
YLBA

(Escherichia
coli) 		PF05899
(Cupin_3)
PF07883
(Cupin_2) 		4 PHE A1076
ILE A1039
PRO A1040
PHE A1119
 None
 1.27A 4fgkA-1rc6A:
undetectable		 4fgkA-1rc6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvf FAB 17-IA

(Mus musculus) 		PF07686
(V-set) 		4 GLN L  89
PHE L  98
ILE L  96
PRO L  95
 None
 1.17A 4fgkA-1rvfL:
undetectable		 4fgkA-1rvfL:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjq DESIGNED PROTEIN

(-) 		PF02244
(Propep_M14) 		4 ILE A  62
PRO A  63
PHE A  64
PHE A   4
 None
 1.26A 4fgkA-1vjqA:
undetectable		 4fgkA-1vjqA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		4 GLN A 260
ILE A 262
PHE A 307
PHE A 305
 None
 1.23A 4fgkA-1w18A:
undetectable		 4fgkA-1w18A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xuv HYPOTHETICAL PROTEIN
MM0500

(Methanosarcina
mazei) 		PF08327
(AHSA1) 		4 GLN A  75
PHE A  85
ILE A  51
PHE A 102
 None
 0.88A 4fgkA-1xuvA:
undetectable		 4fgkA-1xuvA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjj HYPOTHETICAL PROTEIN
PH1952

(Pyrococcus
horikoshii) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ILE A  34
PRO A  35
PHE A  36
PHE A   6
 None
 0.89A 4fgkA-1zjjA:
undetectable		 4fgkA-1zjjA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo sapiens) 		PF00398
(RrnaAD) 		4 PHE A 159
ILE A 133
PRO A 130
PHE A 155
 None
SAM  A4000 ( 4.5A)
SAM  A4000 (-4.1A)
None
 1.17A 4fgkA-1zq9A:
undetectable		 4fgkA-1zq9A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE

(Oryctolagus
cuniculus) 		PF03071
(GNT-I) 		4 PHE A 221
ILE A 108
PHE A 224
PHE A 220
 None
 1.23A 4fgkA-2am4A:
undetectable		 4fgkA-2am4A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buk COAT PROTEIN

(unidentified
tobacco
necrosis virus) 		PF03898
(TNV_CP) 		4 GLN A 122
ILE A 118
PRO A 117
PHE A 125
 None
 0.89A 4fgkA-2bukA:
undetectable		 4fgkA-2bukA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvp HYPOTHETICAL PROTEIN
PH1917

(Pyrococcus
horikoshii) 		PF01725
(Ham1p_like) 		4 PHE A 146
ILE A 145
PRO A 144
PHE A 107
 None
 1.25A 4fgkA-2dvpA:
undetectable		 4fgkA-2dvpA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvz PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03401
(TctC) 		4 PHE A 229
PRO A 235
PHE A 234
PHE A 130
 None
 1.25A 4fgkA-2dvzA:
undetectable		 4fgkA-2dvzA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5v PYRANOSE 2-OXIDASE

(Peniophora sp.
SG) 		PF05199
(GMC_oxred_C) 		4 GLN A 155
PHE A 502
PRO A 543
PHE A 504
 None
 1.18A 4fgkA-2f5vA:
undetectable		 4fgkA-2f5vA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		4 PHE A 440
ILE A  94
PRO A  93
PHE A 441
 None
 1.25A 4fgkA-2gv8A:
undetectable		 4fgkA-2gv8A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p82 CYSTEINE PROTEASE
ATG4A

(Homo sapiens) 		PF03416
(Peptidase_C54) 		4 GLN A  83
PHE A  55
ILE A 128
PHE A 300
 None
 1.19A 4fgkA-2p82A:
undetectable		 4fgkA-2p82A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhz LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN

(Homo sapiens) 		PF02820
(MBT) 		4 PHE A 281
ILE A 247
PRO A 252
PHE A 272
 None
 1.26A 4fgkA-2rhzA:
undetectable		 4fgkA-2rhzA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2u1a U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A

(Homo sapiens) 		PF00076
(RRM_1) 		4 GLN A  36
PHE A  37
PHE A  34
PHE A  57
 None
 1.18A 4fgkA-2u1aA:
undetectable		 4fgkA-2u1aA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9p REPLICATION PROTEIN
E1

(Deltapapillomavirus
4) 		PF00519
(PPV_E1_C) 		4 PHE A 401
ILE A 398
PHE A 402
PHE A 544
 None
 1.26A 4fgkA-2v9pA:
undetectable		 4fgkA-2v9pA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 PHE A 293
ILE A 192
PRO A 193
PHE A 281
 None
 1.11A 4fgkA-2wk2A:
undetectable		 4fgkA-2wk2A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 PHE A 209
ILE A 179
PRO A 181
PHE A 242
 None
 1.00A 4fgkA-2ww2A:
undetectable		 4fgkA-2ww2A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yax SULFUR
OXYGENASE/REDUCTASE

(Acidianus
ambivalens) 		PF07682
(SOR) 		4 GLN B 107
PRO B  17
PHE B  20
PHE B  23
 None
 0.97A 4fgkA-2yaxB:
undetectable		 4fgkA-2yaxB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a7s UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5

(Homo sapiens) 		PF01088
(Peptidase_C12) 		4 PHE A  56
ILE A 216
PHE A 218
PHE A  54
 None
 0.98A 4fgkA-3a7sA:
undetectable		 4fgkA-3a7sA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayr ENDOGLUCANASE

(Piromyces
rhizinflatus) 		PF00150
(Cellulase) 		4 ILE A 225
PRO A 273
PHE A 217
PHE A 215
 None
 1.15A 4fgkA-3ayrA:
undetectable		 4fgkA-3ayrA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Rattus
norvegicus) 		PF06325
(PrmA) 		4 ILE A 373
PRO A 374
PHE A 375
PHE A 377
 None
 0.86A 4fgkA-3b3jA:
undetectable		 4fgkA-3b3jA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4q UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF11574
(DUF3235) 		4 GLN A 178
PHE A 182
ILE A 179
PHE A 193
 None
 1.21A 4fgkA-3b4qA:
undetectable		 4fgkA-3b4qA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bde MLL5499 PROTEIN

(Mesorhizobium
japonicum) 		PF07876
(Dabb) 		4 GLN A  41
PHE A  55
PHE A  53
PHE A   8
 None
 0.97A 4fgkA-3bdeA:
undetectable		 4fgkA-3bdeA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bm3 PSPGI RESTRICTION
ENDONUCLEASE

(Pyrococcus sp.
GI-H) 		PF09019
(EcoRII-C) 		4 ILE A  55
PRO A  52
PHE A 246
PHE A 192
 None
 1.23A 4fgkA-3bm3A:
undetectable		 4fgkA-3bm3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		4 PHE A 359
ILE A 346
PRO A 347
PHE A 350
 None
 1.07A 4fgkA-3bs8A:
undetectable		 4fgkA-3bs8A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvq NOTI RESTRICTION
ENDONUCLEASE

(Nocardia
otitidiscaviarum) 		PF12183
(NotI) 		4 PHE A 301
ILE A 261
PHE A 303
PHE A  90
 None
 1.14A 4fgkA-3bvqA:
undetectable		 4fgkA-3bvqA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxv SULFUR
OXYGENASE/REDUCTASE

(Acidianus
tengchongensis) 		PF07682
(SOR) 		4 GLN A 107
PRO A  17
PHE A  20
PHE A  23
 None
 1.01A 4fgkA-3bxvA:
undetectable		 4fgkA-3bxvA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3co1 MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 3

(Homo sapiens) 		PF00307
(CH) 		4 GLN A 109
PHE A 105
ILE A 108
PHE A 101
 None
 1.21A 4fgkA-3co1A:
undetectable		 4fgkA-3co1A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI

(Monomastix sp.
OKE-1) 		PF00961
(LAGLIDADG_1) 		4 GLN A  41
ILE A  30
PRO A  31
PHE A 128
 None
 1.04A 4fgkA-3fd2A:
undetectable		 4fgkA-3fd2A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI

(Monomastix sp.
OKE-1) 		PF00961
(LAGLIDADG_1) 		4 GLN A 244
ILE A 233
PRO A 234
PHE A 331
 None
 1.15A 4fgkA-3fd2A:
undetectable		 4fgkA-3fd2A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdx PUTATIVE FILAMENT
PROTEIN / UNIVERSAL
STRESS PROTEIN F

(Klebsiella
pneumoniae) 		PF00582
(Usp) 		4 ILE A   6
PRO A   5
PHE A  34
PHE A  85
 None
ATP  A 301 (-4.2A)
None
None
 1.24A 4fgkA-3fdxA:
undetectable		 4fgkA-3fdxA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i05 TRYPTOPHANYL-TRNA
SYNTHETASE

(Trypanosoma
brucei) 		PF00579
(tRNA-synt_1b) 		4 ILE A 123
PRO A 124
PHE A 118
PHE A 155
 None
 1.19A 4fgkA-3i05A:
undetectable		 4fgkA-3i05A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		4 PHE W 698
ILE W 695
PRO W 696
PHE W 697
 None
 1.07A 4fgkA-3iylW:
undetectable		 4fgkA-3iylW:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase) 		4 PHE A 369
ILE A 136
PRO A 134
PHE A 126
 None
 1.27A 4fgkA-3j09A:
2.9		 4fgkA-3j09A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jup PHENAZINE
BIOSYNTHESIS PROTEIN
A/B

(Burkholderia
lata) 		PF03284
(PHZA_PHZB) 		4 PHE A 128
ILE A  91
PHE A 100
PHE A 130
 None
 1.11A 4fgkA-3jupA:
undetectable		 4fgkA-3jupA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k96 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Coxiella
burnetii) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 GLN A  29
PHE A   4
ILE A   8
PRO A   7
 None
 0.94A 4fgkA-3k96A:
5.9		 4fgkA-3k96A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5k HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 1A

(Homo sapiens) 		PF13419
(HAD_2) 		4 ILE A 107
PRO A 108
PHE A 109
PHE A  13
 None
 0.84A 4fgkA-3l5kA:
2.4		 4fgkA-3l5kA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll7 PUTATIVE
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		no annotation 4 PHE A 345
ILE A 343
PRO A 344
PHE A 367
 None
 1.20A 4fgkA-3ll7A:
2.1		 4fgkA-3ll7A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7o ENDOGLUCANASE

(Thermotoga
maritima) 		PF01670
(Glyco_hydro_12) 		5 PHE A 197
ILE A 157
PRO A 158
PHE A 159
PHE A 140
 None
 1.47A 4fgkA-3o7oA:
undetectable		 4fgkA-3o7oA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		4 PHE A 279
ILE A 277
PHE A 244
PHE A 289
 None
 1.27A 4fgkA-3ob8A:
undetectable		 4fgkA-3ob8A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oox PUTATIVE 2OG-FE(II)
OXYGENASE FAMILY
PROTEIN

(Caulobacter
vibrioides) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 PHE A  58
ILE A  79
PRO A  80
PHE A  57
 None
 1.14A 4fgkA-3ooxA:
undetectable		 4fgkA-3ooxA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oxk PUTATIVE HISTIDINE
TRIAD FAMILY PROTEIN

(Entamoeba
histolytica) 		PF01230
(HIT) 		4 PHE A  29
ILE A  15
PRO A  16
PHE A  27
 5GP  A 125 (-4.6A)
None
None
None
 1.20A 4fgkA-3oxkA:
undetectable		 4fgkA-3oxkA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyq DEOXYRIBOSE-PHOSPHAT
E ALDOLASE, PUTATIVE

(Toxoplasma
gondii) 		no annotation 4 PHE A 256
ILE A 243
PRO A 248
PHE A  18
 None
None
SO4  A 287 (-3.6A)
None
 1.26A 4fgkA-3qyqA:
undetectable		 4fgkA-3qyqA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcm TATD FAMILY
HYDROLASE

(Pseudomonas
putida) 		PF01026
(TatD_DNase) 		4 GLN A  33
PHE A  62
ILE A   4
PHE A 262
 None
 1.14A 4fgkA-3rcmA:
undetectable		 4fgkA-3rcmA:
20.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3te7 RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE]

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		4 GLN A 122
ILE A 128
PRO A 129
PHE A 131
 TE7  A   1 ( 4.3A)
None
None
None
 1.02A 4fgkA-3te7A:
38.9		 4fgkA-3te7A:
98.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3te7 RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE]

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		5 GLN A 122
PHE A 126
PRO A 129
PHE A 131
PHE A 178
 TE7  A   1 ( 4.3A)
TE7  A   1 (-4.3A)
None
None
TE7  A   1 (-3.6A)
 0.51A 4fgkA-3te7A:
38.9		 4fgkA-3te7A:
98.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqu NON-CANONICAL PURINE
NTP PYROPHOSPHATASE

(Coxiella
burnetii) 		PF01725
(Ham1p_like) 		4 PHE A 160
ILE A 159
PRO A 158
PHE A 118
 None
 1.25A 4fgkA-3tquA:
undetectable		 4fgkA-3tquA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		4 PHE A 852
ILE A 841
PRO A 962
PHE A 802
 None
 1.24A 4fgkA-3tsyA:
4.6		 4fgkA-3tsyA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v3t CELL DIVISION GTPASE
FTSZ, DIVERGED

(Clostridium
botulinum) 		PF00091
(Tubulin) 		4 PHE A 123
ILE A  10
PRO A   9
PHE A  92
 None
 1.16A 4fgkA-3v3tA:
5.5		 4fgkA-3v3tA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr1 PEPTIDE CHAIN
RELEASE FACTOR 3

(Desulfovibrio
vulgaris) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF16658
(RF3_C) 		4 GLN A 221
ILE A 172
PRO A 171
PHE A 178
 None
 1.18A 4fgkA-3vr1A:
6.0		 4fgkA-3vr1A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 PHE A 533
ILE A 519
PRO A 520
PHE A 789
 None
 1.27A 4fgkA-4a4zA:
undetectable		 4fgkA-4a4zA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A  90
ILE A  86
PRO A  87
PHE A 130
 None
 1.02A 4fgkA-4b99A:
undetectable		 4fgkA-4b99A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bnq NON-CANONICAL PURINE
NTP PYROPHOSPHATASE

(Staphylococcus
aureus) 		PF01725
(Ham1p_like) 		4 PHE A 155
ILE A 154
PRO A 153
PHE A 115
 None
 1.27A 4fgkA-4bnqA:
undetectable		 4fgkA-4bnqA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT) 		4 PHE A 533
ILE A 519
PRO A 520
PHE A 789
 None
 1.21A 4fgkA-4bujA:
undetectable		 4fgkA-4bujA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 PHE A  97
PRO A  99
PHE A 446
PHE A 422
 None
 1.26A 4fgkA-4hzzA:
undetectable		 4fgkA-4hzzA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m46 LUCIFERASE

(Lampyris
turkestanicus) 		PF00501
(AMP-binding) 		4 ILE A 241
PRO A 242
PHE A 243
PHE A  89
 None
 0.92A 4fgkA-4m46A:
3.4		 4fgkA-4m46A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 GLN A  28
ILE A  22
PRO A  21
PHE A  20
 None
 1.12A 4fgkA-4qk3A:
undetectable		 4fgkA-4qk3A:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3i YTH
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF04146
(YTH) 		4 PHE A 455
ILE A 473
PRO A 470
PHE A 409
 None
U  B   5 ( 3.8A)
None
None
 1.17A 4fgkA-4r3iA:
undetectable		 4fgkA-4r3iA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcm METHYLATED
RNA-BINDING PROTEIN
1

(Saccharomyces
cerevisiae) 		PF04146
(YTH) 		4 PHE A 203
ILE A 247
PHE A 201
PHE A 157
 None
 1.21A 4fgkA-4rcmA:
undetectable		 4fgkA-4rcmA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rph UDP-GALACTOPYRANOSE
MUTASE

(Mycobacterium
tuberculosis) 		no annotation 4 GLN B 276
ILE B 312
PHE B 296
PHE B 299
 None
 1.13A 4fgkA-4rphB:
undetectable		 4fgkA-4rphB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		4 PHE A 288
ILE A 293
PRO A 292
PHE A 264
 None
 1.27A 4fgkA-4ufsA:
undetectable		 4fgkA-4ufsA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcj POLYSACCHARIDE
DEACETYLASE

(Ammonifex
degensii) 		PF01522
(Polysacc_deac_1) 		4 ILE A 133
PRO A 134
PHE A 135
PHE A 113
 None
 0.95A 4fgkA-4wcjA:
undetectable		 4fgkA-4wcjA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT

(Pseudomonas
mendocina) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 PHE A 326
ILE A 302
PRO A 298
PHE A 325
 None
None
None
FAD  A 402 (-3.3A)
 0.88A 4fgkA-4wqmA:
3.0		 4fgkA-4wqmA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcq TUBZ

(Clostridium
phage c-st) 		PF00091
(Tubulin) 		4 PHE A 123
ILE A  10
PRO A   9
PHE A  92
 None
 1.11A 4fgkA-4xcqA:
5.6		 4fgkA-4xcqA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE

(Providencia
alcalifaciens) 		PF00551
(Formyl_trans_N)
PF12796
(Ank_2) 		4 GLN A  43
PHE A  42
ILE A 156
PHE A 218
 None
None
None
T3F  A 403 (-4.0A)
 1.24A 4fgkA-4xd0A:
3.5		 4fgkA-4xd0A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A  90
ILE A  86
PRO A  87
PHE A 130
 None
4QZ  A 401 (-4.4A)
None
None
 1.09A 4fgkA-4zslA:
undetectable		 4fgkA-4zslA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zuz SIDC

(Legionella
pneumophila) 		no annotation 4 GLN A 334
PRO A 331
PHE A 332
PHE A 394
 None
 0.97A 4fgkA-4zuzA:
undetectable		 4fgkA-4zuzA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8d CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43) 		4 ILE A  35
PRO A  34
PHE A  36
PHE A 165
 None
 1.12A 4fgkA-5a8dA:
undetectable		 4fgkA-5a8dA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 PHE A 283
ILE A 182
PRO A 183
PHE A 271
 None
 1.04A 4fgkA-5df0A:
undetectable		 4fgkA-5df0A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7o DMSO REDUCTASE
FAMILY TYPE II
ENZYME, IRON-SULFUR
SUBUNIT

(Azospira oryzae) 		PF13247
(Fer4_11) 		4 GLN B 174
PHE B 187
ILE B  78
PRO B  79
 None
 1.12A 4fgkA-5e7oB:
undetectable		 4fgkA-5e7oB:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 PHE A 286
ILE A 185
PRO A 186
PHE A 274
 PHE  A 286 ( 1.3A)
ILE  A 185 ( 0.7A)
PRO  A 186 ( 1.1A)
PHE  A 274 ( 1.3A)
 1.11A 4fgkA-5gprA:
undetectable		 4fgkA-5gprA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxf 3C PROTEASE

(Enterovirus A) 		PF00548
(Peptidase_C3) 		4 PHE A  90
ILE A  91
PRO A  92
PHE A   7
 None
 1.10A 4fgkA-5hxfA:
undetectable		 4fgkA-5hxfA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyv LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 241
PRO A 242
PHE A 243
PHE A  89
 None
 1.06A 4fgkA-5kyvA:
4.1		 4fgkA-5kyvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 2

(Sus scrofa) 		no annotation 4 GLN A 665
PHE A 657
PHE A 652
PHE A 675
 None
 1.21A 4fgkA-5mpmA:
2.0		 4fgkA-5mpmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mw5 PROTEIN JAGGED-2

(Homo sapiens) 		PF01414
(DSL)
PF07657
(MNNL) 		4 ILE A 132
PRO A 133
PHE A 134
PHE A 136
 None
 1.04A 4fgkA-5mw5A:
undetectable		 4fgkA-5mw5A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		4 PHE A 195
PRO A 335
PHE A 336
PHE A 111
 None
 1.15A 4fgkA-5o0sA:
undetectable		 4fgkA-5o0sA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2d DIOXYGENASE

(Pseudomonas
brassicacearum) 		no annotation 4 ILE A   3
PRO A   4
PHE A   5
PHE A  11
 None
 1.15A 4fgkA-5v2dA:
undetectable		 4fgkA-5v2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn5 2,2',3-TRIHYDROXY-3'
-METHOXY-5,5'-DICARB
OXYBIPHENYL
META-CLEAVAGE
COMPOUND HYDROLASE

(Sphingobium sp.
SYK-6) 		PF04909
(Amidohydro_2) 		4 GLN A 100
PHE A 108
ILE A  97
PRO A 110
 None
 1.08A 4fgkA-5vn5A:
undetectable		 4fgkA-5vn5A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5y RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN6

(Saccharomyces
cerevisiae) 		PF10214
(Rrn6) 		4 GLN O 454
ILE O 511
PHE O 537
PHE O 467
 None
 1.27A 4fgkA-5w5yO:
undetectable		 4fgkA-5w5yO:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x06 DNAA REGULATORY
INACTIVATOR HDA

(Escherichia
coli) 		no annotation 4 GLN E  35
PHE E  19
PRO E  24
PHE E  22
 None
None
None
ADP  E1001 (-3.3A)
 1.25A 4fgkA-5x06E:
undetectable		 4fgkA-5x06E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y81 ACTIN-RELATED
PROTEIN 4

(Saccharomyces
cerevisiae) 		no annotation 4 PHE F 238
ILE F 204
PRO F 205
PHE F 239
 None
 0.91A 4fgkA-5y81F:
undetectable		 4fgkA-5y81F:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykn PROBABLE
LYSINE-SPECIFIC
DEMETHYLASE JMJ14

(Arabidopsis
thaliana) 		no annotation 4 GLN A 116
PHE A 171
ILE A 118
PHE A 169
 None
 1.20A 4fgkA-5yknA:
undetectable		 4fgkA-5yknA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 4 PHE A 293
ILE A 192
PRO A 193
PHE A 281
 None
 1.13A 4fgkA-5zl9A:
undetectable		 4fgkA-5zl9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpc RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 4 PHE A 202
ILE A 221
PHE A 205
PHE A 201
 None
 1.05A 4fgkA-6bpcA:
undetectable		 4fgkA-6bpcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btp -

(-) 		no annotation 4 ILE A  15
PRO A  16
PHE A  17
PHE A  58
 None
 1.00A 4fgkA-6btpA:
undetectable		 4fgkA-6btpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cqb CHALCONE SYNTHASE

(Piper
methysticum) 		no annotation 4 PHE A 266
ILE A 255
PRO A 376
PHE A 216
 None
 1.21A 4fgkA-6cqbA:
undetectable		 4fgkA-6cqbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0s TBC1 DOMAIN FAMILY
MEMBER 22B

(Homo sapiens) 		no annotation 4 GLN A 284
PRO A 280
PHE A 282
PHE A 291
 None
 1.27A 4fgkA-6d0sA:
undetectable		 4fgkA-6d0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Homo sapiens) 		no annotation 4 ILE A 372
PRO A 373
PHE A 374
PHE A 376
 None
 0.96A 4fgkA-6d2lA:
undetectable		 4fgkA-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dm8 -

(-) 		no annotation 4 PHE A 299
ILE A 245
PHE A 296
PHE A 300
 None
 1.27A 4fgkA-6dm8A:
undetectable		 4fgkA-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT 7

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 PHE o  76
ILE L 472
PRO L 473
PHE L  55
 None
 1.27A 4fgkA-6g2jo:
undetectable		 4fgkA-6g2jo:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvw PROTEIN
(CELLOBIOHYDROLASE
II)

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		4 GLY A 401
GLY A 402
TYR A 438
ASN A 373
 None
 1.05A 4fgkB-1bvwA:
undetectable		 4fgkB-1bvwA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dms DMSO REDUCTASE

(Rhodobacter
capsulatus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 GLY A 716
GLY A 717
TYR A 733
GLU A 715
 None
None
None
PGD  A 782 (-3.9A)
 1.03A 4fgkB-1dmsA:
undetectable		 4fgkB-1dmsA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dys ENDOGLUCANASE

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		4 GLY A 312
GLY A 313
TYR A 334
ASN A 284
 None
 0.93A 4fgkB-1dysA:
undetectable		 4fgkB-1dysA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 GLY A 716
GLY A 717
TYR A 733
GLU A 715
 None
None
None
MGD  A1001 (-3.9A)
 1.05A 4fgkB-1eu1A:
undetectable		 4fgkB-1eu1A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		4 GLY A 508
GLY A 507
ASN A 505
GLU A 207
 None
 0.66A 4fgkB-1fehA:
undetectable		 4fgkB-1fehA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fyh INTERFERON GAMMA
INTERFERON GAMMA
RECEPTOR 1

(Homo sapiens;
Homo sapiens) 		PF00714
(IFN-gamma)
PF01108
(Tissue_fac)
PF07140
(IFNGR1) 		4 GLY A  26
GLY B  50
TYR B  49
ASN B  79
 None
 1.09A 4fgkB-1fyhA:
undetectable		 4fgkB-1fyhA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		4 GLY C 102
GLY C 101
ASN C  97
GLU C 106
 None
 1.08A 4fgkB-1h2tC:
undetectable		 4fgkB-1h2tC:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3g CYCLOMALTODEXTRINASE

(Flavobacterium
sp. 92) 		PF00128
(Alpha-amylase)
PF09087
(Cyc-maltodext_N)
PF10438
(Cyc-maltodext_C) 		4 TRP A 477
GLY A 141
GLY A 140
GLU A 132
 None
 1.00A 4fgkB-1h3gA:
undetectable		 4fgkB-1h3gA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnz SPO0B-ASSOCIATED
GTP-BINDING PROTEIN

(Bacillus
subtilis) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		4 GLY A 123
GLY A 122
ASN A  81
GLU A 141
 None
 1.10A 4fgkB-1lnzA:
3.4		 4fgkB-1lnzA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mx3 C-TERMINAL BINDING
PROTEIN 1

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLY A 267
GLY A 268
ASN A 243
GLU A 295
 None
None
NAD  A1000 (-4.2A)
None
 0.81A 4fgkB-1mx3A:
4.9		 4fgkB-1mx3A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pto PERTUSSIS TOXIN

(Bordetella
pertussis) 		PF02918
(Pertussis_S2S3)
PF03440
(APT) 		4 GLY B  65
GLY B  64
TYR B  62
GLU B  66
 None
 0.96A 4fgkB-1ptoB:
undetectable		 4fgkB-1ptoB:
20.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		5 TRP A 105
GLY A 149
GLY A 150
MET A 154
TYR A 155
 FAD  A 501 (-4.5A)
FAD  A 501 (-3.9A)
FAD  A 501 (-4.0A)
None
FAD  A 501 (-4.9A)
 0.52A 4fgkB-1qbgA:
32.6		 4fgkB-1qbgA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcj POKEWEED ANTIVIRAL
PROTEIN

(Phytolacca
americana) 		PF00161
(RIP) 		4 GLY A 257
GLY A 256
TYR A 254
ASN A  42
 None
 0.94A 4fgkB-1qcjA:
undetectable		 4fgkB-1qcjA:
23.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qrd QUINONE-REDUCTASE

(Rattus rattus) 		PF02525
(Flavodoxin_2) 		5 TRP A 105
GLY A 149
GLY A 150
MET A 154
TYR A 155
 DQN  A 276 ( 3.6A)
CBD  A 275 ( 3.7A)
FAD  A 274 (-3.7A)
CBD  A 275 ( 4.4A)
None
 0.44A 4fgkB-1qrdA:
29.6		 4fgkB-1qrdA:
41.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF14519
(Macro_2) 		4 GLY A  86
GLY A  87
TYR A 197
GLU A 103
 EDO  A 286 (-3.7A)
APR  A 285 (-3.3A)
APR  A 285 (-4.0A)
None
 0.86A 4fgkB-1txzA:
undetectable		 4fgkB-1txzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wek HYPOTHETICAL PROTEIN
TT1465

(Thermus
thermophilus) 		PF03641
(Lysine_decarbox) 		4 GLY A  77
MET A  81
ASN A  85
GLU A 105
 None
 1.03A 4fgkB-1wekA:
6.3		 4fgkB-1wekA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A

(Pyrococcus
horikoshii) 		PF00117
(GATase) 		4 GLY A  51
GLY A  52
ASN A  57
GLU A 168
 CL  A1202 ( 3.7A)
None
None
None
 1.04A 4fgkB-1wl8A:
5.1		 4fgkB-1wl8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiw T-CELL SURFACE
GLYCOPROTEIN CD3
EPSILON CHAIN
IMMUNOGLOBULIN HEAVY
CHAIN VARIABLE
REGION

(Homo sapiens;
Mus musculus) 		PF16681
(Ig_5)
PF07686
(V-set) 		4 GLY A  46
GLY A  47
TYR D 101
ASN D  52
 None
 1.07A 4fgkB-1xiwA:
undetectable		 4fgkB-1xiwA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE

(Chlorobaculum
tepidum) 		PF04371
(PAD_porph) 		4 GLY A 125
GLY A 124
ASN A 177
GLU A 128
 None
 0.96A 4fgkB-1xknA:
undetectable		 4fgkB-1xknA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a22 VACUOLAR PROTEIN
SORTING 29

(Cryptosporidium
parvum) 		PF12850
(Metallophos_2) 		4 GLY A  93
TYR A  39
ASN A  38
GLU A  94
 None
 0.98A 4fgkB-2a22A:
undetectable		 4fgkB-2a22A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 GLY A 227
GLY A 228
TYR A 239
GLU A 224
 None
 0.86A 4fgkB-2b5mA:
undetectable		 4fgkB-2b5mA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Bacillus
subtilis) 		PF01182
(Glucosamine_iso) 		4 GLY A  38
GLY A  37
TYR A 168
ASN A 165
 F6R  A1243 (-3.7A)
F6R  A1243 (-3.5A)
None
F6R  A1243 ( 4.8A)
 1.02A 4fgkB-2bkxA:
2.3		 4fgkB-2bkxA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejv L-THREONINE
3-DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 TRP A 292
GLY A 298
TYR A 303
ASN A 135
 None
 0.89A 4fgkB-2ejvA:
3.7		 4fgkB-2ejvA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		4 GLY A 153
GLY A 131
MET A 421
ASN A 424
 None
GLN  A 501 ( 4.5A)
None
None
 0.88A 4fgkB-2f2aA:
undetectable		 4fgkB-2f2aA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		4 GLY B 505
TYR B 486
ASN B 781
GLU B 511
 None
 1.01A 4fgkB-2fffB:
undetectable		 4fgkB-2fffB:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT

(Streptococcus
mutans) 		PF04223
(CitF) 		4 GLY A 150
GLY A 149
ASN A 352
GLU A 498
 None
 0.97A 4fgkB-2hj0A:
2.3		 4fgkB-2hj0A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		4 GLY A 435
GLY A 434
MET A 533
GLU A 551
 None
None
None
CAC  A 705 ( 4.8A)
 1.11A 4fgkB-2i0kA:
undetectable		 4fgkB-2i0kA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilu ALDEHYDE
DEHYDROGENASE A

(Escherichia
coli) 		PF00171
(Aldedh) 		4 TRP A 152
GLY A 253
GLY A 254
GLU A 251
 NDP  A 482 (-4.1A)
None
SO4  A 480 (-3.1A)
None
 0.90A 4fgkB-2iluA:
undetectable		 4fgkB-2iluA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jch PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		4 GLY A 505
TYR A 486
ASN A 781
GLU A 511
 None
 1.04A 4fgkB-2jchA:
undetectable		 4fgkB-2jchA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k0d COLICIN-E7 IMMUNITY
PROTEIN

(Escherichia
coli) 		PF01320
(Colicin_Pyocin) 		4 GLY X  69
GLY X  70
ASN X  64
GLU X  78
 None
 1.11A 4fgkB-2k0dX:
undetectable		 4fgkB-2k0dX:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 GLY A 104
TYR A 364
ASN A 363
GLU A 109
 None
 1.06A 4fgkB-2np0A:
undetectable		 4fgkB-2np0A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ome C-TERMINAL-BINDING
PROTEIN 2

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLY A 273
GLY A 274
ASN A 249
GLU A 301
 None
None
NAD  A 901 (-4.2A)
None
 0.72A 4fgkB-2omeA:
4.8		 4fgkB-2omeA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm1 GLUCOKINASE

(Enterococcus
faecalis) 		PF00480
(ROK) 		4 GLY A 144
GLY A 145
ASN A 116
GLU A 185
 None
MG  A1007 (-4.6A)
MG  A1007 (-2.8A)
None
 1.04A 4fgkB-2qm1A:
undetectable		 4fgkB-2qm1A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 GLY A  72
GLY A  73
TYR A  75
ASN A 156
 None
 0.69A 4fgkB-2vcaA:
undetectable		 4fgkB-2vcaA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		4 TRP A 159
GLY A 196
GLY A 197
GLU A 123
 None
 1.11A 4fgkB-2vg2A:
undetectable		 4fgkB-2vg2A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3n CARBONIC ANHYDRASE 2

(Cryptococcus
neoformans) 		PF00484
(Pro_CA) 		4 GLY A 192
MET A 112
ASN A 108
GLU A 195
 None
 0.89A 4fgkB-2w3nA:
2.6		 4fgkB-2w3nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A  99
GLY A  98
ASN A 151
GLU A 100
 None
 1.12A 4fgkB-2w4kA:
undetectable		 4fgkB-2w4kA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLY A 661
GLY A 662
MET A 713
GLU A 718
 None
 0.63A 4fgkB-3actA:
undetectable		 4fgkB-3actA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 215
GLY A 216
TYR A 218
ASN A 167
 None
 0.81A 4fgkB-3aw5A:
undetectable		 4fgkB-3aw5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwq CAPSID PROTEIN VP1

(Macaca mulatta
polyomavirus 1) 		PF00718
(Polyoma_coat) 		4 GLY A 227
GLY A 226
TYR A 224
GLU A 228
 None
 0.97A 4fgkB-3bwqA:
undetectable		 4fgkB-3bwqA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fai BETA-LACTAMASE

(Aeromonas
hydrophila) 		PF00753
(Lactamase_B) 		4 TRP A  87
GLY A 262
GLY A 220
ASN A 116
 None
None
None
CL  A   4 (-4.1A)
 0.97A 4fgkB-3faiA:
undetectable		 4fgkB-3faiA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 GLY A   1
GLY A   0
TYR A  -3
GLU A   5
 None
 0.88A 4fgkB-3hkoA:
undetectable		 4fgkB-3hkoA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Burkholderia
mallei) 		PF13458
(Peripla_BP_6) 		4 GLY A  48
GLY A  47
MET A 295
TYR A 291
 None
 1.05A 4fgkB-3i09A:
undetectable		 4fgkB-3i09A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6y ESTERASE APC40077

(Oleispira
antarctica) 		PF00756
(Esterase) 		4 TRP A 182
GLY A 150
GLY A 151
ASN A 175
 None
 1.01A 4fgkB-3i6yA:
undetectable		 4fgkB-3i6yA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ii7 KELCH-LIKE PROTEIN 7

(Homo sapiens) 		PF01344
(Kelch_1) 		4 GLY A 437
GLY A 436
MET A 467
ASN A 449
 None
 1.06A 4fgkB-3ii7A:
undetectable		 4fgkB-3ii7A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE

(Caenorhabditis
elegans) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 GLY A  48
GLY A  51
ASN A 150
GLU A  78
 PO4  A 503 ( 3.8A)
None
None
None
 1.08A 4fgkB-3k6jA:
4.5		 4fgkB-3k6jA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE

(Thermococcus
sibiricus) 		PF00106
(adh_short) 		4 GLY A 148
GLY A 149
MET A 106
ASN A 110
 None
None
None
NJP  A 501 ( 4.8A)
 1.06A 4fgkB-3l77A:
7.0		 4fgkB-3l77A:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln6 GLUTATHIONE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
GSHAB

(Streptococcus
agalactiae) 		PF01071
(GARS_A)
PF04262
(Glu_cys_ligase) 		4 GLY A 663
GLY A 664
ASN A 592
GLU A 623
 None
 1.07A 4fgkB-3ln6A:
undetectable		 4fgkB-3ln6A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
E

(Homo sapiens) 		PF00076
(RRM_1) 		4 GLY A  12
GLY A  11
TYR A   9
ASN A  80
 None
 1.06A 4fgkB-3lpyA:
undetectable		 4fgkB-3lpyA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om9 LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A 294
GLY A 297
MET A 159
ASN A 158
 None
 0.98A 4fgkB-3om9A:
4.8		 4fgkB-3om9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE

(Staphylococcus
aureus) 		PF02222
(ATP-grasp)
PF02826
(2-Hacid_dh_C) 		4 GLY A  17
GLY A  16
TYR A  58
ASN A  80
 None
 0.62A 4fgkB-3orqA:
3.3		 4fgkB-3orqA:
18.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3te7 RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE]

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		7 TRP A 105
GLY A 149
GLY A 150
MET A 154
TYR A 155
ASN A 161
GLU A 193
 FAD  A 232 ( 4.3A)
FAD  A 232 (-3.6A)
FAD  A 232 (-3.6A)
None
FAD  A 232 (-4.6A)
None
FAD  A 232 ( 3.1A)
 0.39A 4fgkB-3te7A:
39.6		 4fgkB-3te7A:
98.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttl POLYAMINE TRANSPORT
PROTEIN

(Pseudomonas
aeruginosa) 		PF13416
(SBP_bac_8) 		4 TRP A 132
GLY A 136
TYR A 261
GLU A 181
 None
 1.09A 4fgkB-3ttlA:
undetectable		 4fgkB-3ttlA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb9 UNCHARACTERIZED
PROTEIN VPA0735

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		4 GLY A 156
GLY A 157
TYR A 159
GLU A 128
 None
 0.98A 4fgkB-3vb9A:
undetectable		 4fgkB-3vb9A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb9 UNCHARACTERIZED
PROTEIN VPA0735

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		4 GLY A 156
GLY A 157
TYR A 177
GLU A 128
 None
 1.10A 4fgkB-3vb9A:
undetectable		 4fgkB-3vb9A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voh CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		4 GLY A 384
GLY A 385
TYR A 421
ASN A 356
 None
 1.00A 4fgkB-3vohA:
undetectable		 4fgkB-3vohA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vov GLUCOKINASE

(Thermus
thermophilus) 		PF00480
(ROK) 		4 GLY A 137
GLY A 138
ASN A 109
GLU A 178
 None
 1.12A 4fgkB-3vovA:
undetectable		 4fgkB-3vovA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vov GLUCOKINASE

(Thermus
thermophilus) 		PF00480
(ROK) 		4 GLY A 137
GLY A 138
TYR A 129
GLU A 178
 None
 1.04A 4fgkB-3vovA:
undetectable		 4fgkB-3vovA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zk6 BCL-2-LIKE PROTEIN 1

(Homo sapiens) 		PF00452
(Bcl-2)
PF02180
(BH4) 		4 GLY A 148
GLY A 147
MET A 170
GLU A  98
 None
 1.10A 4fgkB-3zk6A:
undetectable		 4fgkB-3zk6A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a05 CELLOBIOHYDROLASE
FAMILY 6

(Chaetomium
thermophilum) 		PF01341
(Glyco_hydro_6) 		4 GLY A 427
GLY A 428
TYR A 464
ASN A 399
 None
 1.04A 4fgkB-4a05A:
undetectable		 4fgkB-4a05A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 GLY A 268
GLY A 271
ASN A 256
GLU A 269
 None
 1.10A 4fgkB-4c7vA:
3.9		 4fgkB-4c7vA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8o ANKYRIN-2

(Homo sapiens) 		PF00531
(Death)
PF00791
(ZU5) 		4 GLY A1135
GLY A1136
ASN A1129
GLU A1152
 None
 0.93A 4fgkB-4d8oA:
undetectable		 4fgkB-4d8oA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dal PUTATIVE ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 GLY A 204
GLY A 208
ASN A 213
GLU A 175
 None
 1.04A 4fgkB-4dalA:
2.8		 4fgkB-4dalA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4j ARGININE DEIMINASE

(Mycoplasma
penetrans) 		PF02274
(Amidinotransf) 		4 GLY A 210
GLY A 212
TYR A 246
ASN A 292
 None
 1.12A 4fgkB-4e4jA:
undetectable		 4fgkB-4e4jA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eps HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF13149
(Mfa_like_1) 		4 GLY A 519
GLY A 520
TYR A 526
ASN A 524
 GOL  A 615 ( 4.0A)
None
GOL  A 621 ( 4.7A)
GOL  A 621 (-3.8A)
 0.88A 4fgkB-4epsA:
undetectable		 4fgkB-4epsA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwm PROPIONATE KINASE

(Salmonella
enterica) 		PF00871
(Acetate_kinase) 		4 GLY A  91
GLY A  90
ASN A 119
GLU A  92
 None
 1.11A 4fgkB-4fwmA:
undetectable		 4fgkB-4fwmA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0y PROTEIN ARGONAUTE 1

(Arabidopsis
thaliana) 		PF02171
(Piwi) 		4 GLY A 602
GLY A 601
MET A 598
ASN A 737
 None
 0.80A 4fgkB-4g0yA:
undetectable		 4fgkB-4g0yA:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gi5 QUINONE REDUCTASE

(Klebsiella
pneumoniae) 		PF02525
(Flavodoxin_2) 		5 TRP A 102
GLY A 154
GLY A 155
TYR A 160
ASN A 166
 FAD  A 301 (-4.1A)
FAD  A 301 (-3.6A)
FAD  A 301 (-3.5A)
FAD  A 301 (-4.7A)
None
 0.53A 4fgkB-4gi5A:
30.1		 4fgkB-4gi5A:
39.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glp MONOCYTE
DIFFERENTIATION
ANTIGEN CD14

(Homo sapiens) 		PF13516
(LRR_6) 		4 TRP A  45
GLY A  62
GLY A  63
ASN A  65
 None
 1.12A 4fgkB-4glpA:
undetectable		 4fgkB-4glpA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyy MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG

(Homo sapiens) 		PF08423
(Rad51) 		4 GLY A 290
GLY A 289
MET A 226
ASN A 268
 None
 1.07A 4fgkB-4hyyA:
undetectable		 4fgkB-4hyyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5u CHIMERIC CEL6A

(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		PF01341
(Glyco_hydro_6) 		4 GLY A 397
GLY A 398
TYR A 434
ASN A 369
 None
 1.05A 4fgkB-4i5uA:
undetectable		 4fgkB-4i5uA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia4 AQUAPORIN

(Spinacia
oleracea) 		PF00230
(MIP) 		4 TRP A 239
GLY A 150
GLY A 151
ASN A 153
 None
 0.89A 4fgkB-4ia4A:
undetectable		 4fgkB-4ia4A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 GLY A 145
GLY A 146
TYR A 138
ASN A 140
 None
None
None
CD  A1108 ( 3.1A)
 0.89A 4fgkB-4iugA:
undetectable		 4fgkB-4iugA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kca ENDO-1,5-ALPHA-L-ARA
BINANASE

(Bos taurus) 		PF00085
(Thioredoxin)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 GLY A 267
GLY A 266
ASN A 305
GLU A 273
 None
 0.91A 4fgkB-4kcaA:
undetectable		 4fgkB-4kcaA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 GLY A 127
MET A  88
ASN A  86
GLU A 141
 None
 1.11A 4fgkB-4mivA:
undetectable		 4fgkB-4mivA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 GLY A 375
GLY A 376
TYR A 378
GLU A 374
 None
 1.11A 4fgkB-4o1oA:
undetectable		 4fgkB-4o1oA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(unidentified) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 GLY A  32
GLY A  31
ASN A  24
GLU A  74
 None
 1.05A 4fgkB-4pytA:
undetectable		 4fgkB-4pytA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 GLY A 398
GLY A 399
TYR A 164
GLU A 185
 None
 1.08A 4fgkB-4q6rA:
2.1		 4fgkB-4q6rA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qez 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Bacillus
anthracis) 		no annotation 4 GLY B 144
TYR B 170
ASN B 168
GLU B 130
 None
 1.05A 4fgkB-4qezB:
2.1		 4fgkB-4qezB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		PF00145
(DNA_methylase) 		4 GLY A 543
GLY A 542
TYR A 536
GLU A 561
 ZN  A1002 ( 4.6A)
None
None
None
 1.05A 4fgkB-4u7tA:
3.6		 4fgkB-4u7tA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		4 TRP A 559
GLY A 623
GLY A 608
GLU A 640
 None
None
None
CA  A1777 (-2.7A)
 1.06A 4fgkB-4v1uA:
3.4		 4fgkB-4v1uA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		4 TRP C 272
GLY C 394
GLY C 393
ASN C 527
 None
 0.98A 4fgkB-5aa5C:
undetectable		 4fgkB-5aa5C:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c41 RIBOKINASE

(Homo sapiens) 		PF00294
(PfkB) 		4 GLY A  53
GLY A  52
TYR A  84
ASN A  87
 None
 0.97A 4fgkB-5c41A:
3.7		 4fgkB-5c41A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 GLY A 474
GLY A 473
TYR A 439
GLU A 485
 0GA  A 604 ( 4.4A)
0GA  A 604 (-3.8A)
0GA  A 604 ( 4.4A)
None
 1.08A 4fgkB-5cwaA:
undetectable		 4fgkB-5cwaA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza C
virus) 		PF00604
(Flu_PB2) 		4 GLY C 338
MET C 450
TYR C 447
ASN C 451
 None
 1.07A 4fgkB-5d9aC:
undetectable		 4fgkB-5d9aC:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 GLY A 468
GLY A 469
TYR A 496
GLU A 198
 None
 0.97A 4fgkB-5f7sA:
undetectable		 4fgkB-5f7sA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 GLY A 227
GLY A 228
TYR A 239
GLU A 224
 None
 1.05A 4fgkB-5fqdA:
undetectable		 4fgkB-5fqdA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 GLY A 126
GLY A 127
MET A 263
GLU A 200
 None
 1.01A 4fgkB-5iq0A:
3.1		 4fgkB-5iq0A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))

(Thermoplasma
acidophilum) 		PF00171
(Aldedh) 		4 TRP A 148
GLY A 249
GLY A 250
GLU A 247
 NAP  A 601 (-4.0A)
None
None
None
 1.08A 4fgkB-5izdA:
2.5		 4fgkB-5izdA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j90 RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12741
(SusD-like) 		4 GLY A 369
GLY A 368
ASN A 366
GLU A 373
 None
 1.03A 4fgkB-5j90A:
undetectable		 4fgkB-5j90A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lh9 OMEGA TRANSAMINASE

(Pseudomonas sp.) 		PF00202
(Aminotran_3) 		4 TRP A  54
GLY A 150
TYR A 164
ASN A 161
 None
PLP  A1001 (-3.1A)
None
None
 1.03A 4fgkB-5lh9A:
undetectable		 4fgkB-5lh9A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lva NAD(P)H-FMN
OXIDOREDUCTASE

(Bacillus
subtilis) 		PF02525
(Flavodoxin_2) 		4 TRP A  68
GLY A 108
TYR A 114
ASN A 120
 FMN  A 201 (-4.4A)
FMN  A 201 (-3.6A)
FMN  A 201 (-4.9A)
None
 0.53A 4fgkB-5lvaA:
19.8		 4fgkB-5lvaA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nck N-ACETYLMANNOSAMINE
KINASE

(Fusobacterium
nucleatum) 		PF00480
(ROK) 		4 GLY A 137
GLY A 138
ASN A 109
GLU A 168
 None
 1.08A 4fgkB-5nckA:
undetectable		 4fgkB-5nckA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982) 		4 GLY A 756
GLY A 755
TYR A 753
GLU A 780
 None
 0.91A 4fgkB-5uj6A:
undetectable		 4fgkB-5uj6A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vol PUTATIVE ESTERASE

(Bacteroides
intestinalis) 		PF00756
(Esterase) 		4 TRP A  73
GLY A 157
GLY A 156
MET A 179
 None
 1.03A 4fgkB-5volA:
undetectable		 4fgkB-5volA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		4 TRP A 402
GLY A1344
GLY A1343
GLU A1341
 ATP  A1501 (-3.3A)
None
None
None
 1.06A 4fgkB-5w81A:
undetectable		 4fgkB-5w81A:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvo DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		no annotation 4 GLY C 451
GLY C 452
ASN C 383
GLU C 450
 None
 0.84A 4fgkB-5wvoC:
undetectable		 4fgkB-5wvoC:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 4 GLY A 452
GLY A 453
TYR A 480
GLU A 189
 None
None
None
GLC  A 819 ( 2.8A)
 0.92A 4fgkB-5x3jA:
undetectable		 4fgkB-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcy GLUCANASE

(Phanerochaete
chrysosporium) 		PF01341
(Glyco_hydro_6) 		4 GLY A 390
GLY A 391
TYR A 427
ASN A 362
 None
 0.98A 4fgkB-5xcyA:
2.4		 4fgkB-5xcyA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eot DIPEPTIDYL PEPTIDASE
8

(Homo sapiens) 		no annotation 4 GLY A 183
GLY A 185
TYR A 187
GLU A 152
 None
 1.09A 4fgkB-6eotA:
2.8		 4fgkB-6eotA:
undetectable