SIMILAR PATTERNS OF AMINO ACIDS FOR 4FFW_B_715B801_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amk TRIOSE PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00121
(TIM) 		3 ARG A 243
TYR A 223
ASN A 218
 None
 0.94A 4ffwB-1amkA:
undetectable		 4ffwB-1amkA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		3 ARG C 403
TYR C 334
ASN C 330
 None
HEM  A 605 ( 4.8A)
None
 0.87A 4ffwB-1d7wC:
undetectable		 4ffwB-1d7wC:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbw ENDO-1,4-BETA-GLUCAN
ASE F

([Clostridium]
cellulolyticum) 		PF02011
(Glyco_hydro_48) 		3 ARG A 268
TYR A 393
ASN A 319
 None
 0.79A 4ffwB-1fbwA:
0.0		 4ffwB-1fbwA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbw ENDO-1,4-BETA-GLUCAN
ASE F

([Clostridium]
cellulolyticum) 		PF02011
(Glyco_hydro_48) 		3 ARG A 277
TYR A 294
ASN A 319
 None
 0.89A 4ffwB-1fbwA:
0.0		 4ffwB-1fbwA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 ARG A 731
TYR A 725
ASN A  65
 None
 0.96A 4ffwB-1h17A:
0.0		 4ffwB-1h17A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1irx LYSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01921
(tRNA-synt_1f) 		3 ARG A  72
TYR A  33
ASN A  38
 None
 0.82A 4ffwB-1irxA:
0.2		 4ffwB-1irxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jro XANTHINE
DEHYDROGENASE, CHAIN
A

(Rhodobacter
capsulatus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		3 ARG A  58
TYR A 125
ASN A 132
 None
 0.81A 4ffwB-1jroA:
undetectable		 4ffwB-1jroA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A1354
TYR A1361
ASN A1345
 None
 0.82A 4ffwB-1larA:
2.6		 4ffwB-1larA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		3 ARG A 413
TYR A 443
ASN A 468
 None
 0.73A 4ffwB-1qhoA:
0.0		 4ffwB-1qhoA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8g HYPOTHETICAL PROTEIN
YBDK

(Escherichia
coli) 		PF04107
(GCS2) 		3 ARG A 182
TYR A 290
ASN A 343
 None
 0.72A 4ffwB-1r8gA:
undetectable		 4ffwB-1r8gA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE

(Arabidopsis
thaliana) 		PF07992
(Pyr_redox_2) 		3 ARG A 144
TYR A 172
ASN A 193
 None
 0.73A 4ffwB-1vdcA:
undetectable		 4ffwB-1vdcA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6j LANOSTEROL SYNTHASE

(Homo sapiens) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		3 ARG A 435
TYR A 528
ASN A 495
 None
 0.88A 4ffwB-1w6jA:
undetectable		 4ffwB-1w6jA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 ARG A 289
TYR A 347
ASN A 473
 None
 0.65A 4ffwB-1w99A:
undetectable		 4ffwB-1w99A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woi AGMATINASE

(Deinococcus
radiodurans) 		PF00491
(Arginase) 		3 ARG A 164
TYR A 225
ASN A 172
 None
 0.86A 4ffwB-1woiA:
undetectable		 4ffwB-1woiA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xbr PROTEIN (T PROTEIN)

(Xenopus laevis) 		PF00907
(T-box) 		3 ARG A  68
TYR A 164
ASN A  58
 None
 0.69A 4ffwB-1xbrA:
undetectable		 4ffwB-1xbrA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrz XYLAN
BETA-1,4-XYLOSIDASE

(Bacillus
halodurans) 		PF04616
(Glyco_hydro_43) 		3 ARG A1051
TYR A1523
ASN A1337
 None
 0.94A 4ffwB-1yrzA:
6.1		 4ffwB-1yrzA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ARG A 212
TYR A 133
ASN A 195
 None
 0.75A 4ffwB-1zpuA:
undetectable		 4ffwB-1zpuA:
21.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ARG A 358
TYR A 631
ASN A 710
 008  A1767 ( 4.0A)
None
008  A1767 (-3.0A)
 0.80A 4ffwB-2bucA:
51.3		 4ffwB-2bucA:
81.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A1154
TYR A 979
ASN A 948
 None
 0.88A 4ffwB-2bzlA:
undetectable		 4ffwB-2bzlA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 ARG A 328
TYR A 389
ASN A 531
 None
 0.71A 4ffwB-2c9kA:
undetectable		 4ffwB-2c9kA:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ARG A 358
TYR A 631
ASN A 710
 None
None
ACF  A 800 (-3.3A)
 0.48A 4ffwB-2g5tA:
51.6		 4ffwB-2g5tA:
84.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj7 GLYCOPROTEIN E

(Human
alphaherpesvirus
1) 		no annotation 3 ARG F 316
TYR F 311
ASN F 364
 None
 0.66A 4ffwB-2gj7F:
undetectable		 4ffwB-2gj7F:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		3 ARG A 591
TYR A 563
ASN A 605
 None
 0.86A 4ffwB-2i0kA:
undetectable		 4ffwB-2i0kA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqf CATALASE

(Helicobacter
pylori) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 ARG A 101
TYR A 339
ASN A 357
 None
HEM  A 550 (-3.8A)
None
 0.55A 4ffwB-2iqfA:
undetectable		 4ffwB-2iqfA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isa CATALASE

(Aliivibrio
salmonicida) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 ARG A  99
TYR A 337
ASN A 355
 None
HEM  A 486 (-4.1A)
None
 0.73A 4ffwB-2isaA:
undetectable		 4ffwB-2isaA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2
G2/MITOTIC-SPECIFIC
CYCLIN-B1

(Homo sapiens) 		PF00069
(Pkinase)
PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		3 ARG B 308
TYR A 179
ASN A 272
 None
 0.91A 4ffwB-2jgzB:
undetectable		 4ffwB-2jgzB:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		3 ARG A 128
TYR A 160
ASN A 463
 None
 0.75A 4ffwB-2nyfA:
undetectable		 4ffwB-2nyfA:
21.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ARG A 356
TYR A 632
ASN A 711
 AIL  A 901 ( 4.7A)
None
AIL  A 901 (-3.1A)
 0.53A 4ffwB-2oaeA:
52.2		 4ffwB-2oaeA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q42 PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 2

(Arabidopsis
thaliana) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		3 ARG A  69
TYR A  49
ASN A  52
 None
 0.93A 4ffwB-2q42A:
undetectable		 4ffwB-2q42A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		3 ARG A  66
TYR A 516
ASN A 576
 None
 0.93A 4ffwB-2rdyA:
undetectable		 4ffwB-2rdyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 ARG A 343
TYR A 202
ASN A 356
 None
 0.75A 4ffwB-2vpwA:
undetectable		 4ffwB-2vpwA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrk ALPHA-L-ARABINOFURAN
OSIDASE

(Thermobacillus
xylanilyticus) 		PF06964
(Alpha-L-AF_C) 		3 ARG A 339
TYR A  23
ASN A 344
 None
 0.95A 4ffwB-2vrkA:
undetectable		 4ffwB-2vrkA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6d DYNAMIN FAMILY
PROTEIN

(Nostoc
punctiforme) 		PF00350
(Dynamin_N) 		3 ARG A 264
TYR A 274
ASN A 281
 None
 0.67A 4ffwB-2w6dA:
undetectable		 4ffwB-2w6dA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Sus scrofa) 		PF13561
(adh_short_C2) 		3 ARG A 185
TYR A 244
ASN A 190
 None
 0.93A 4ffwB-2zatA:
undetectable		 4ffwB-2zatA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyl POSSIBLE
OXIDOREDUCTASE

(Mycobacterium
tuberculosis) 		PF00355
(Rieske) 		3 ARG A 313
TYR A 260
ASN A 257
 None
 0.91A 4ffwB-2zylA:
undetectable		 4ffwB-2zylA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8i PA4872 OXALOACETATE
DECARBOXYLASE

(Pseudomonas
aeruginosa) 		PF13714
(PEP_mutase) 		3 ARG A 222
TYR A  23
ASN A 233
 None
 0.72A 4ffwB-3b8iA:
undetectable		 4ffwB-3b8iA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		3 ARG A 471
TYR A 214
ASN A 498
 None
 0.73A 4ffwB-3cttA:
undetectable		 4ffwB-3cttA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A 153
TYR A 358
ASN A 326
 None
 0.90A 4ffwB-3dfhA:
undetectable		 4ffwB-3dfhA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli) 		PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C) 		3 ARG B 404
TYR B 415
ASN B 374
 None
 0.92A 4ffwB-3egwB:
undetectable		 4ffwB-3egwB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 ARG A 925
TYR A 630
ASN A 633
 None
 0.56A 4ffwB-3eh1A:
undetectable		 4ffwB-3eh1A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas) 		PF00890
(FAD_binding_2) 		3 ARG A 336
TYR A 413
ASN A 276
 None
 0.79A 4ffwB-3gyxA:
undetectable		 4ffwB-3gyxA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h77 PQS BIOSYNTHETIC
ENZYME

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 ARG A 109
TYR A 315
ASN A 287
 None
None
CSJ  A 112 ( 3.8A)
 0.85A 4ffwB-3h77A:
undetectable		 4ffwB-3h77A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 5

(Thermus
thermophilus) 		PF00329
(Complex1_30kDa)
PF00346
(Complex1_49kDa)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		3 ARG 5 189
TYR 3 140
ASN 4 306
 None
 0.91A 4ffwB-3i9v5:
undetectable		 4ffwB-3i9v5:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izy TRANSLATION
INITIATION FACTOR
IF-2, MITOCHONDRIAL

(Bos taurus) 		PF00009
(GTP_EFTU)
PF11987
(IF-2) 		3 ARG P 397
TYR P 411
ASN P 403
 None
 0.95A 4ffwB-3izyP:
undetectable		 4ffwB-3izyP:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq0 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ARG A  87
TYR A 103
ASN A  60
 None
 0.94A 4ffwB-3jq0A:
undetectable		 4ffwB-3jq0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Ruegeria
pomeroyi) 		PF00356
(LacI)
PF00532
(Peripla_BP_1) 		3 ARG A 200
TYR A 251
ASN A 281
 None
 0.94A 4ffwB-3kjxA:
2.8		 4ffwB-3kjxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lew SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ARG A 492
TYR A  66
ASN A  63
 None
 0.96A 4ffwB-3lewA:
undetectable		 4ffwB-3lewA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ARG A 107
TYR A 116
ASN A  56
 None
 0.89A 4ffwB-3snxA:
undetectable		 4ffwB-3snxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
marinum) 		no annotation 3 ARG B 116
TYR B 168
ASN B 139
 None
 0.93A 4ffwB-3tzqB:
3.1		 4ffwB-3tzqB:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wew HTDX DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF01575
(MaoC_dehydratas) 		3 ARG A 147
TYR A 223
ASN A 195
 None
 0.97A 4ffwB-3wewA:
undetectable		 4ffwB-3wewA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wih ANTI-HUMAN ROBO1
ANTIBODY B2212A FAB
HEAVY CHAIN
ROUNDABOUT HOMOLOG 1

(Homo sapiens;
Mus musculus) 		PF00041
(fn3)
PF07654
(C1-set)
PF07686
(V-set) 		3 ARG A  50
TYR H  32
ASN H  35
 None
 0.86A 4ffwB-3wihA:
undetectable		 4ffwB-3wihA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0l CULLIN-4B

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		3 ARG E 889
TYR E 598
ASN E 557
 None
 0.84A 4ffwB-4a0lE:
undetectable		 4ffwB-4a0lE:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw7 GH86A
BETA-PORPHYRANASE

(Bacteroides
plebeius) 		no annotation 3 ARG A 217
TYR A 237
ASN A 253
 CL  A1615 ( 4.7A)
GLA  A1608 (-4.0A)
None
 0.70A 4ffwB-4aw7A:
2.0		 4ffwB-4aw7A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bms ALCLOHOL
DEHYDROGENASE/SHORT-
CHAIN DEHYDROGENASE

(Ralstonia sp.
DSMZ 6428) 		PF13561
(adh_short_C2) 		3 ARG A 171
TYR A 234
ASN A 176
 None
 0.89A 4ffwB-4bmsA:
undetectable		 4ffwB-4bmsA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A1421
TYR A1428
ASN A1412
 None
 0.82A 4ffwB-4bpcA:
undetectable		 4ffwB-4bpcA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dun PUTATIVE PHENAZINE
BIOSYNTHESIS
PHZC/PHZF PROTEIN

(Clostridioides
difficile) 		PF02567
(PhzC-PhzF) 		3 ARG A  58
TYR A   4
ASN A  40
 None
 0.94A 4ffwB-4dunA:
undetectable		 4ffwB-4dunA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e37 CATALASE

(Pseudomonas
aeruginosa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 ARG A 100
TYR A 338
ASN A 356
 None
HEM  A 500 (-4.0A)
None
 0.53A 4ffwB-4e37A:
undetectable		 4ffwB-4e37A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fas HYDROXYLAMINE
OXIDOREDUCTASE

(Nitrosomonas
europaea) 		PF13447
(Multi-haem_cyto) 		3 ARG A 165
TYR A 208
ASN A 241
 None
None
HEC  A 605 (-3.5A)
 0.90A 4ffwB-4fasA:
undetectable		 4ffwB-4fasA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fff LEVAN
FRUCTOTRANSFERASE

(Paenarthrobacter
ureafaciens) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 ARG A  57
TYR A 298
ASN A 341
 None
 0.81A 4ffwB-4fffA:
6.7		 4ffwB-4fffA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gis ENOLASE

(Vibrio harveyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A 151
TYR A 356
ASN A 324
 None
 0.96A 4ffwB-4gisA:
undetectable		 4ffwB-4gisA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq6 ACETYL-COA
CARBOXYLASE 2

(Homo sapiens) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 ARG A 281
TYR A 683
ASN A 673
 None
 0.95A 4ffwB-4hq6A:
undetectable		 4ffwB-4hq6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE

(Staphylococcus
aureus) 		PF13416
(SBP_bac_8) 		3 ARG A 306
TYR A 201
ASN A 196
 None
None
MAL  A 506 (-3.7A)
 0.73A 4ffwB-4hw8A:
undetectable		 4ffwB-4hw8A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Escherichia
coli) 		PF03331
(LpxC) 		3 ARG A 237
TYR A 261
ASN A 268
 None
FMT  A 415 (-3.4A)
None
 0.91A 4ffwB-4isaA:
undetectable		 4ffwB-4isaA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks9 MALONYL-COA
DECARBOXYLASE

(Cupriavidus
metallidurans) 		PF05292
(MCD)
PF17408
(MCD_N) 		3 ARG A 467
TYR A 444
ASN A 454
 None
 0.95A 4ffwB-4ks9A:
undetectable		 4ffwB-4ks9A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 3 ARG A 467
TYR A 551
ASN A 531
 None
 0.82A 4ffwB-4oj5A:
undetectable		 4ffwB-4oj5A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psw HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00583
(Acetyltransf_1)
PF10394
(Hat1_N) 		3 ARG A 267
TYR A 278
ASN A 318
 COA  A 401 (-3.2A)
None
None
 0.87A 4ffwB-4pswA:
2.5		 4ffwB-4pswA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q00 FERROUS IRON
TRANSPORT PROTEIN B

(Escherichia
coli) 		PF02421
(FeoB_N) 		3 ARG A 140
TYR A 103
ASN A  91
 None
 0.86A 4ffwB-4q00A:
3.0		 4ffwB-4q00A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN

(Streptomyces
sp. SirexAA-E) 		no annotation 3 ARG A 551
TYR A 485
ASN A 501
 None
 0.82A 4ffwB-4tz5A:
undetectable		 4ffwB-4tz5A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18) 		3 ARG A  44
TYR A 284
ASN A 221
 None
None
MPD  A 402 ( 4.6A)
 0.61A 4ffwB-4w5zA:
undetectable		 4ffwB-4w5zA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2

(Caenorhabditis
elegans) 		PF00004
(AAA) 		3 ARG A 340
TYR A 328
ASN A 138
 None
 0.76A 4ffwB-4xguA:
undetectable		 4ffwB-4xguA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwl EXOGLUCANASE S

(Clostridium
cellulovorans) 		PF02011
(Glyco_hydro_48) 		3 ARG A 260
TYR A 385
ASN A 311
 None
P33  A 705 (-3.9A)
None
 0.78A 4ffwB-4xwlA:
undetectable		 4ffwB-4xwlA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwl EXOGLUCANASE S

(Clostridium
cellulovorans) 		PF02011
(Glyco_hydro_48) 		3 ARG A 269
TYR A 286
ASN A 311
 None
 0.83A 4ffwB-4xwlA:
undetectable		 4ffwB-4xwlA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE

(Streptomyces
hygroscopicus) 		no annotation 3 ARG A 290
TYR A  36
ASN A  17
 None
 0.96A 4ffwB-5a3kA:
undetectable		 4ffwB-5a3kA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzt CYLM

(Enterococcus
faecalis) 		PF05147
(LANC_like)
PF13575
(DUF4135) 		3 ARG A 979
TYR A 705
ASN A 757
 None
 0.86A 4ffwB-5dztA:
undetectable		 4ffwB-5dztA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6p PLEXIN-B2

(Mus musculus) 		PF08337
(Plexin_cytopl) 		3 ARG A1783
TYR A1369
ASN A1328
 None
 0.96A 4ffwB-5e6pA:
undetectable		 4ffwB-5e6pA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epz ANGIOGENIN

(Homo sapiens) 		PF00074
(RnaseA) 		3 ARG A   5
TYR A  14
ASN A  43
 None
 0.89A 4ffwB-5epzA:
undetectable		 4ffwB-5epzA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyb DNA-BINDING PROTEIN
REB1

(Schizosaccharomyces
pombe) 		PF00249
(Myb_DNA-binding) 		3 ARG A 313
TYR A 307
ASN A 269
 None
 0.89A 4ffwB-5eybA:
undetectable		 4ffwB-5eybA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmx CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		3 ARG A 304
TYR A 279
ASN A 335
 None
 0.93A 4ffwB-5gmxA:
undetectable		 4ffwB-5gmxA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A1755
TYR A1762
ASN A1746
 None
 0.75A 4ffwB-5h08A:
undetectable		 4ffwB-5h08A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9x BETA-1,3-GLUCANASE

(Paenibacillus
barengoltzii) 		PF16483
(Glyco_hydro_64) 		3 ARG A 197
TYR A 207
ASN A 162
 None
 0.97A 4ffwB-5h9xA:
undetectable		 4ffwB-5h9xA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldt MOMP PORIN

(Campylobacter
jejuni) 		PF05538
(Campylo_MOMP) 		3 ARG A 316
TYR A 250
ASN A 238
 None
 0.96A 4ffwB-5ldtA:
undetectable		 4ffwB-5ldtA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Pyrobaculum
calidifontis) 		PF00490
(ALAD) 		3 ARG A 302
TYR A  35
ASN A 282
 None
 0.85A 4ffwB-5lzlA:
undetectable		 4ffwB-5lzlA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		3 ARG A 569
TYR A 500
ASN A 496
 None
HEM  A 812 ( 4.3A)
None
 0.86A 4ffwB-5mfaA:
undetectable		 4ffwB-5mfaA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhj MAJOR VIRAL
TRANSCRIPTION FACTOR
ICP4

(Human
alphaherpesvirus
1) 		PF03584
(Herpes_ICP4_N) 		3 ARG A 471
TYR A 373
ASN A 482
 None
None
ACY  A 501 (-3.3A)
 0.88A 4ffwB-5mhjA:
undetectable		 4ffwB-5mhjA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhk RS1

(Human
alphaherpesvirus
1) 		PF03584
(Herpes_ICP4_N) 		3 ARG A 471
TYR A 373
ASN A 482
 SO4  A 501 (-3.1A)
None
None
 0.87A 4ffwB-5mhkA:
undetectable		 4ffwB-5mhkA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		3 ARG A1077
TYR A 346
ASN A 350
 None
 0.79A 4ffwB-5mqsA:
3.7		 4ffwB-5mqsA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		3 ARG A 197
TYR A 270
ASN A 413
 None
 0.97A 4ffwB-5n6uA:
undetectable		 4ffwB-5n6uA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 ARG B 750
TYR B 456
ASN B 459
 None
 0.71A 4ffwB-5vniB:
3.7		 4ffwB-5vniB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w76 ANCESTRAL ELOGATION
FACTOR N153

(synthetic
construct) 		no annotation 3 ARG A 124
TYR A  88
ASN A 356
 None
 0.90A 4ffwB-5w76A:
3.5		 4ffwB-5w76A:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wva SHORT-CHAIN
DEHYDROGENASE

(Serratia
marcescens) 		no annotation 3 ARG A 179
TYR A 235
ASN A 184
 None
 0.84A 4ffwB-5wvaA:
2.9		 4ffwB-5wvaA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Mus musculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		3 ARG A 148
TYR A  66
ASN A 188
 None
 0.76A 4ffwB-5xa1A:
undetectable		 4ffwB-5xa1A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xez GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme)
PF02793
(HRM) 		3 ARG A 413
TYR A 343
ASN A 174
 None
 0.87A 4ffwB-5xezA:
undetectable		 4ffwB-5xezA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzb CYCLIC GMP-AMP
SYNTHASE

(Mus musculus) 		PF03281
(Mab-21) 		3 ARG A 158
TYR A 201
ASN A 376
 None
 0.90A 4ffwB-5xzbA:
undetectable		 4ffwB-5xzbA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvs ALCOHOL
DEHYDROGENASE

(candidate
divison MSBL1
archaeon
SCGC-AAA259E19) 		no annotation 3 ARG A 272
TYR A 283
ASN A  71
 None
None
NDP  A 502 (-3.4A)
 0.76A 4ffwB-5yvsA:
undetectable		 4ffwB-5yvsA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 3 ARG A 518
TYR A 556
ASN A 577
 None
 0.92A 4ffwB-5z06A:
undetectable		 4ffwB-5z06A:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 3 ARG A 569
TYR A 500
ASN A 496
 None
 0.84A 4ffwB-6azpA:
undetectable		 4ffwB-6azpA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bli CB002.5 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 3 ARG A 100
TYR A  32
ASN A  35
 None
 0.75A 4ffwB-6bliA:
undetectable		 4ffwB-6bliA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 SODIUM-COUPLED
NEUTRAL AMINO ACID
TRANSPORTER 9

(Danio rerio) 		no annotation 3 ARG C 495
TYR C 204
ASN C 210
 None
 0.86A 4ffwB-6c08C:
undetectable		 4ffwB-6c08C:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c93 CYTOCHROME P450 4B1

(Oryctolagus
cuniculus) 		no annotation 3 ARG A 259
TYR A 206
ASN A 200
 None
 0.90A 4ffwB-6c93A:
undetectable		 4ffwB-6c93A:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 3 ARG A 600
TYR A 668
ASN A 672
 None
EDO  A 902 (-3.9A)
None
 0.94A 4ffwB-6fnwA:
2.6		 4ffwB-6fnwA:
12.86