SIMILAR PATTERNS OF AMINO ACIDS FOR 4FFW_A_715A801_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2

(Homo sapiens) 		PF00145
(DNA_methylase) 		3 PHE A 293
TYR A 342
TYR A 370
 None
 1.05A 4ffwA-1g55A:
2.3		 4ffwA-1g55A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnz GSI-B4 ISOLECTIN

(Griffonia
simplicifolia) 		PF00139
(Lectin_legB) 		3 PHE A  77
TYR A 196
TYR A 190
 None
 1.05A 4ffwA-1gnzA:
1.6		 4ffwA-1gnzA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h09 LYSOZYME

(Streptococcus
virus Cp1) 		PF01183
(Glyco_hydro_25)
PF01473
(CW_binding_1) 		3 PHE A  61
TYR A 127
TYR A 125
 None
 1.05A 4ffwA-1h09A:
2.8		 4ffwA-1h09A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		3 PHE C 271
TYR C 121
TYR C 169
 None
 0.86A 4ffwA-1h2tC:
undetectable		 4ffwA-1h2tC:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv6 ALGINATE LYASE

(Sphingomonas
sp.) 		PF05426
(Alginate_lyase) 		3 PHE A   8
TYR A 269
TYR A 220
 None
 1.10A 4ffwA-1hv6A:
undetectable		 4ffwA-1hv6A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		3 PHE A 467
TYR A 350
TYR A 372
 None
 1.10A 4ffwA-1j3bA:
undetectable		 4ffwA-1j3bA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV

(Griffonia
simplicifolia) 		PF00139
(Lectin_legB) 		3 PHE A  78
TYR A 197
TYR A 191
 None
 1.04A 4ffwA-1ledA:
1.3		 4ffwA-1ledA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvh CRYPTIC LOCI
REGULATOR 4

(Schizosaccharomyces
pombe) 		PF00856
(SET)
PF05033
(Pre-SET) 		3 PHE A 449
TYR A 381
TYR A 357
 None
 0.92A 4ffwA-1mvhA:
undetectable		 4ffwA-1mvhA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt4 GLUCOSE-1-PHOSPHATAS
E

(Escherichia
coli) 		PF00328
(His_Phos_2) 		3 PHE A 127
TYR A  86
TYR A 268
 None
 0.97A 4ffwA-1nt4A:
undetectable		 4ffwA-1nt4A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF01074
(Glyco_hydro_38)
PF09261
(Alpha-mann_mid) 		3 PHE A 253
TYR A 307
TYR B 359
 None
 0.80A 4ffwA-1o7dA:
undetectable		 4ffwA-1o7dA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pox PYRUVATE OXIDASE

(Lactobacillus
plantarum) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 PHE A 302
TYR A 287
TYR A 218
 None
FAD  A 612 (-4.7A)
None
 1.08A 4ffwA-1poxA:
2.8		 4ffwA-1poxA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		3 PHE A 529
TYR A 486
TYR A 523
 None
 1.10A 4ffwA-1q3xA:
undetectable		 4ffwA-1q3xA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN (VIRUS
CAPSID PROTEIN VP2)

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 PHE 2  62
TYR 2 171
TYR 2  91
 None
 1.08A 4ffwA-1qgc2:
undetectable		 4ffwA-1qgc2:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 PHE A 503
TYR A 482
TYR A 497
 None
 1.10A 4ffwA-1qgrA:
undetectable		 4ffwA-1qgrA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tki TITIN

(Homo sapiens) 		PF00069
(Pkinase) 		3 PHE A 114
TYR A 124
TYR A 152
 None
 0.75A 4ffwA-1tkiA:
3.1		 4ffwA-1tkiA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tly NUCLEOSIDE-SPECIFIC
CHANNEL-FORMING
PROTEIN TSX

(Escherichia
coli) 		PF03502
(Channel_Tsx) 		3 PHE A  50
TYR A  53
TYR A  51
 None
 1.07A 4ffwA-1tlyA:
undetectable		 4ffwA-1tlyA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		3 PHE A 471
TYR A 534
TYR A 484
 None
 0.74A 4ffwA-1w7cA:
2.6		 4ffwA-1w7cA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI

(Escherichia
coli) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 PHE A 230
TYR A 206
TYR A 200
 None
 0.86A 4ffwA-1we5A:
undetectable		 4ffwA-1we5A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1d LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF02217
(T_Ag_DNA_bind) 		3 PHE B  69
TYR B  83
TYR B  51
 None
 0.92A 4ffwA-1z1dB:
undetectable		 4ffwA-1z1dB:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a39 ENDOGLUCANASE I

(Humicola
insolens) 		PF00840
(Glyco_hydro_7) 		3 PHE A 177
TYR A 147
TYR A 171
 None
 1.11A 4ffwA-2a39A:
undetectable		 4ffwA-2a39A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkl PROLYL ENDOPEPTIDASE

(Myxococcus
xanthus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 PHE A 384
TYR A 451
TYR A 478
 None
 0.96A 4ffwA-2bklA:
26.3		 4ffwA-2bklA:
22.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 PHE A 357
TYR A 631
TYR A 666
 008  A1767 (-3.5A)
None
008  A1767 (-3.8A)
 0.25A 4ffwA-2bucA:
52.0		 4ffwA-2bucA:
81.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE

(Enterococcus
faecalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		3 PHE A 209
TYR A 243
TYR A 250
 None
 0.85A 4ffwA-2ew2A:
undetectable		 4ffwA-2ew2A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus sp.
GL1) 		PF07470
(Glyco_hydro_88) 		3 PHE A  91
TYR A 228
TYR A 356
 GAD  A 404 (-4.4A)
None
None
 1.04A 4ffwA-2fv0A:
undetectable		 4ffwA-2fv0A:
18.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 PHE A 357
TYR A 631
TYR A 666
 None
None
ACF  A 800 (-3.3A)
 0.26A 4ffwA-2g5tA:
53.1		 4ffwA-2g5tA:
84.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		3 PHE A 298
TYR A 409
TYR A 484
 None
 0.95A 4ffwA-2hpiA:
undetectable		 4ffwA-2hpiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id0 EXORIBONUCLEASE 2

(Escherichia
coli) 		PF00575
(S1)
PF00773
(RNB)
PF08206
(OB_RNB) 		3 PHE A 553
TYR A 364
TYR A 550
 None
 0.88A 4ffwA-2id0A:
undetectable		 4ffwA-2id0A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4v PORIN P

(Pseudomonas
aeruginosa) 		PF07396
(Porin_O_P) 		3 PHE A 117
TYR A 298
TYR A 137
 None
 1.06A 4ffwA-2o4vA:
undetectable		 4ffwA-2o4vA:
19.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 PHE A 355
TYR A 632
TYR A 667
 AIL  A 901 (-3.7A)
None
AIL  A 901 (-3.8A)
 0.31A 4ffwA-2oaeA:
52.2		 4ffwA-2oaeA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C

(Neurospora
crassa) 		PF00225
(Kinesin) 		3 PHE A 141
TYR A 406
TYR A 143
 None
 1.10A 4ffwA-2owmA:
undetectable		 4ffwA-2owmA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		3 PHE A  87
TYR A 161
TYR A 169
 None
 0.94A 4ffwA-2pyxA:
undetectable		 4ffwA-2pyxA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2w PLASMINOGEN
ACTIVATOR, UROKINASE

(Homo sapiens) 		PF00089
(Trypsin) 		3 PHE U 141
TYR U  67
TYR U  34
 None
 1.05A 4ffwA-2r2wU:
undetectable		 4ffwA-2r2wU:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y35 LD22664P

(Drosophila
melanogaster) 		PF03159
(XRN_N) 		3 PHE A 243
TYR A  67
TYR A 202
 None
 0.91A 4ffwA-2y35A:
2.3		 4ffwA-2y35A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybu ACIDIC MAMMALIAN
CHITINASE

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		3 PHE A 367
TYR A 294
TYR A 304
 None
 1.09A 4ffwA-2ybuA:
undetectable		 4ffwA-2ybuA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp. JT-ISH-224) 		PF11477
(PM0188) 		3 PHE A 453
TYR A 241
TYR A 297
 None
 1.05A 4ffwA-2z4tA:
undetectable		 4ffwA-2z4tA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvw PROLIFERATING CELL
NUCLEAR ANTIGEN 2

(Arabidopsis
thaliana) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 PHE A 144
TYR A 249
TYR A 239
 None
 1.08A 4ffwA-2zvwA:
undetectable		 4ffwA-2zvwA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzr UNSATURATED
GLUCURONYL HYDROLASE

(Streptococcus
agalactiae) 		PF07470
(Glyco_hydro_88) 		3 PHE A 118
TYR A 254
TYR A 382
 None
 1.07A 4ffwA-2zzrA:
undetectable		 4ffwA-2zzrA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt7 TRNA
(URACIL-5-)-METHYLTR
ANSFERASE

(Escherichia
coli) 		PF05958
(tRNA_U5-meth_tr) 		3 PHE A  77
TYR A 353
TYR A  44
 U  C  55 ( 4.9A)
None
None
 1.05A 4ffwA-3bt7A:
undetectable		 4ffwA-3bt7A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpi RAB GDP-DISSOCIATION
INHIBITOR

(Saccharomyces
cerevisiae) 		PF00996
(GDI) 		3 PHE G 151
TYR G 205
TYR G 180
 None
 1.11A 4ffwA-3cpiG:
undetectable		 4ffwA-3cpiG:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efy CIF (CELL CYCLE
INHIBITING FACTOR)

(Escherichia
coli) 		PF16374
(CIF) 		3 PHE A 260
TYR A 218
TYR A 167
 None
 0.90A 4ffwA-3efyA:
undetectable		 4ffwA-3efyA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehc SNOAL-LIKE
POLYKETIDE CYCLASE

(Agrobacterium
fabrum) 		PF07366
(SnoaL) 		3 PHE A  59
TYR A  43
TYR A  11
 None
 0.83A 4ffwA-3ehcA:
2.1		 4ffwA-3ehcA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehk PRUNIN

(Prunus dulcis) 		PF00190
(Cupin_1) 		3 PHE A 449
TYR A 407
TYR A 468
 None
 1.11A 4ffwA-3ehkA:
undetectable		 4ffwA-3ehkA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzg 16S RRNA METHYLASE

(Escherichia
coli) 		PF07091
(FmrO) 		3 PHE A 195
TYR A 136
TYR A 169
 None
SAM  A 300 (-4.7A)
None
 0.96A 4ffwA-3fzgA:
undetectable		 4ffwA-3fzgA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas) 		PF00890
(FAD_binding_2) 		3 PHE A 278
TYR A 287
TYR A 413
 None
 0.93A 4ffwA-3gyxA:
undetectable		 4ffwA-3gyxA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd6 AMMONIUM TRANSPORTER
RH TYPE C

(Homo sapiens) 		PF00909
(Ammonium_transp) 		3 PHE A 139
TYR A 435
TYR A  84
 None
 1.04A 4ffwA-3hd6A:
undetectable		 4ffwA-3hd6A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 PHE A 322
TYR A 451
TYR A 324
 None
 1.03A 4ffwA-3iv0A:
undetectable		 4ffwA-3iv0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8z H16.1A HEAVY CHAIN

(Mus musculus) 		no annotation 3 PHE H  29
TYR H 102
TYR H  27
 None
 1.05A 4ffwA-3j8zH:
undetectable		 4ffwA-3j8zH:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		3 PHE X1180
TYR X1248
TYR X1128
 None
 1.01A 4ffwA-3jb9X:
undetectable		 4ffwA-3jb9X:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg6 CURF

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		3 PHE A1728
TYR A1885
TYR A1716
 None
 1.05A 4ffwA-3kg6A:
undetectable		 4ffwA-3kg6A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg9 CURK

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		3 PHE A1004
TYR A1161
TYR A 992
 None
 1.04A 4ffwA-3kg9A:
2.1		 4ffwA-3kg9A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE

(Enterobacter
cloacae) 		PF00328
(His_Phos_2) 		3 PHE A 125
TYR A  84
TYR A 266
 None
 0.88A 4ffwA-3ntlA:
undetectable		 4ffwA-3ntlA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc5 TOXIN COREGULATED
PILUS BIOSYNTHESIS
PROTEIN F

(Vibrio cholerae) 		PF06340
(TcpF) 		3 PHE A  79
TYR A  99
TYR A  63
 None
 1.04A 4ffwA-3oc5A:
undetectable		 4ffwA-3oc5A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		3 PHE A 191
TYR A 416
TYR A 189
 None
 0.99A 4ffwA-3oksA:
undetectable		 4ffwA-3oksA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ol2 SEMAPHORIN-4D

(Homo sapiens) 		PF00047
(ig)
PF01403
(Sema)
PF01437
(PSI) 		3 PHE A  71
TYR A  48
TYR A  50
 None
NAG  A1000 ( 4.6A)
None
 1.04A 4ffwA-3ol2A:
2.8		 4ffwA-3ol2A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q64 MLL3774 PROTEIN

(Mesorhizobium
loti) 		PF08327
(AHSA1) 		3 PHE A  49
TYR A  88
TYR A  73
 None
 0.79A 4ffwA-3q64A:
undetectable		 4ffwA-3q64A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8n 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		3 PHE A 198
TYR A 417
TYR A 196
 None
 0.96A 4ffwA-3q8nA:
undetectable		 4ffwA-3q8nA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5w L-ORNITHINE
5-MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF13434
(K_oxygenase) 		3 PHE A 188
TYR A 230
TYR A 193
 None
 1.07A 4ffwA-3s5wA:
undetectable		 4ffwA-3s5wA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc8 LEUCINE
AMINOPEPTIDASE

(Parabacteroides
distasonis) 		PF04389
(Peptidase_M28) 		3 PHE A 186
TYR A 181
TYR A  95
 None
 1.02A 4ffwA-3tc8A:
5.2		 4ffwA-3tc8A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb9 UNCHARACTERIZED
PROTEIN VPA0735

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		3 PHE A 457
TYR A 343
TYR A 303
 None
 0.80A 4ffwA-3vb9A:
undetectable		 4ffwA-3vb9A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl1 CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		3 PHE A 379
TYR A 303
TYR A 313
 None
 1.10A 4ffwA-3wl1A:
undetectable		 4ffwA-3wl1A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zth STU0660

(Streptococcus
thermophilus) 		PF16813
(Cas_St_Csn2) 		3 PHE A  55
TYR A  41
TYR A  47
 None
 1.06A 4ffwA-3zthA:
undetectable		 4ffwA-3zthA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		3 PHE A1189
TYR A1125
TYR A1182
 None
 0.88A 4ffwA-4a4zA:
undetectable		 4ffwA-4a4zA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atq 4-AMINOBUTYRATE
TRANSAMINASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		3 PHE A 198
TYR A 424
TYR A 196
 None
 0.98A 4ffwA-4atqA:
undetectable		 4ffwA-4atqA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bug ANCILLARY PROTEIN 1

(Streptococcus
pyogenes) 		PF08341
(TED) 		3 PHE A 535
TYR A 412
TYR A 408
 None
 1.09A 4ffwA-4bugA:
undetectable		 4ffwA-4bugA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT) 		3 PHE A1189
TYR A1125
TYR A1182
 None
 0.87A 4ffwA-4bujA:
undetectable		 4ffwA-4bujA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cs5 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Litopenaeus
vannamei) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 PHE A 144
TYR A 249
TYR A 239
 None
 1.11A 4ffwA-4cs5A:
undetectable		 4ffwA-4cs5A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 PHE H 529
TYR H 486
TYR H 523
 None
 1.00A 4ffwA-4fxgH:
undetectable		 4ffwA-4fxgH:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdf LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF02217
(T_Ag_DNA_bind)
PF06431
(Polyoma_lg_T_C) 		3 PHE A 197
TYR A 211
TYR A 179
 None
 1.09A 4ffwA-4gdfA:
undetectable		 4ffwA-4gdfA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP2

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 PHE B  62
TYR B 171
TYR B  91
 None
 0.98A 4ffwA-4gh4B:
undetectable		 4ffwA-4gh4B:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gul PIRIN

(Homo sapiens) 		PF02678
(Pirin)
PF05726
(Pirin_C) 		3 PHE A  42
TYR A  66
TYR A 171
 None
 1.04A 4ffwA-4gulA:
undetectable		 4ffwA-4gulA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0c PHOSPHOLIPASE/CARBOX
YLESTERASE

(Dyadobacter
fermentans) 		PF02230
(Abhydrolase_2) 		3 PHE A 146
TYR A 114
TYR A 122
 None
 0.92A 4ffwA-4h0cA:
13.9		 4ffwA-4h0cA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Drosophila
melanogaster) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 PHE A 144
TYR A 249
TYR A 239
 None
 1.02A 4ffwA-4hk1A:
undetectable		 4ffwA-4hk1A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu0 CELLULASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		3 PHE A 318
TYR A 260
TYR A 310
 None
CTT  A 401 (-4.3A)
None
 0.87A 4ffwA-4hu0A:
undetectable		 4ffwA-4hu0A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2u ANTIBODY HEAVY CHAIN
ANTIBODY LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PHE L  94
TYR H  33
TYR H 100
 SO4  H 303 (-4.6A)
SO4  H 303 (-4.3A)
SO4  H 303 (-4.4A)
 0.91A 4ffwA-4k2uL:
undetectable		 4ffwA-4k2uL:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf7 ENDO-1,4-BETA-GLUCAN
ASE CEL5C

(Butyrivibrio
proteoclasticus) 		PF00150
(Cellulase) 		3 PHE A  65
TYR A  74
TYR A  67
 None
 1.10A 4ffwA-4nf7A:
undetectable		 4ffwA-4nf7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nux INTERLEUKIN-17
RECEPTOR A

(Homo sapiens) 		PF08357
(SEFIR) 		3 PHE A 504
TYR A 384
TYR A 391
 None
 1.06A 4ffwA-4nuxA:
2.5		 4ffwA-4nuxA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ook METHIONINE
AMINOPEPTIDASE 2

(Mycobacterium
tuberculosis) 		PF00557
(Peptidase_M24) 		3 PHE A 211
TYR A  91
TYR A  27
 None
 1.11A 4ffwA-4ookA:
undetectable		 4ffwA-4ookA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovx XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

(Planctopirus
limnophila) 		PF01261
(AP_endonuc_2) 		3 PHE A  59
TYR A  84
TYR A  89
 None
 0.92A 4ffwA-4ovxA:
undetectable		 4ffwA-4ovxA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzk TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE

(Streptomyces
blastmyceticus) 		PF11991
(Trp_DMAT) 		3 PHE A  36
TYR A  47
TYR A 388
 None
 1.09A 4ffwA-4yzkA:
undetectable		 4ffwA-4yzkA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		3 PHE A 275
TYR A 571
TYR A 313
 None
 1.08A 4ffwA-4z2aA:
undetectable		 4ffwA-4z2aA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN

(Homo sapiens) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 PHE A 144
TYR A 249
TYR A 239
 None
 1.02A 4ffwA-4ztdA:
undetectable		 4ffwA-4ztdA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7o PROLIFERATING CELL
NUCLEAR ANTIGEN

(Leishmania
donovani) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 PHE A 144
TYR A 282
TYR A 272
 None
 0.92A 4ffwA-5b7oA:
undetectable		 4ffwA-5b7oA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfk PROLIFERATING CELL
NUCLEAR
ANTIGEN,PROLIFERATIN
G CELL NUCLEAR
ANTIGEN

(Leishmania
donovani) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 PHE A 144
TYR A 249
TYR A 239
 None
 0.87A 4ffwA-5cfkA:
undetectable		 4ffwA-5cfkA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyn LARGE T ANTIGEN

(Human
polyomavirus 2) 		PF02217
(T_Ag_DNA_bind) 		3 PHE A 198
TYR A 212
TYR A 180
 None
 1.10A 4ffwA-5cynA:
undetectable		 4ffwA-5cynA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE

(Streptomyces
halstedii) 		no annotation 3 PHE A  80
TYR A 209
TYR A  72
 None
None
GOL  A 401 ( 4.2A)
 1.10A 4ffwA-5czcA:
undetectable		 4ffwA-5czcA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eft P9-1

(Southern rice
black-streaked
dwarf virus) 		PF06043
(Reo_P9) 		3 PHE B 199
TYR B  12
TYR B 223
 None
 1.04A 4ffwA-5eftB:
undetectable		 4ffwA-5eftB:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC98

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		3 PHE B 593
TYR B 758
TYR B 652
 None
 1.10A 4ffwA-5flzB:
undetectable		 4ffwA-5flzB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gll GLYCOSIDE HYDROLASE
FAMILY 43

(uncultured
bacterium) 		PF04616
(Glyco_hydro_43) 		3 PHE A 181
TYR A 300
TYR A 191
 None
 1.09A 4ffwA-5gllA:
undetectable		 4ffwA-5gllA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm0 ALPHA-MANNOSIDASE,AL
PHA-MANNOSIDASE,ALPH
A-MANNOSIDASE

(Saccharomyces
cerevisiae) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 PHE A 333
TYR A 498
TYR A 331
 None
 1.05A 4ffwA-5jm0A:
undetectable		 4ffwA-5jm0A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		3 PHE A 565
TYR A 608
TYR A 548
 None
 1.02A 4ffwA-5ljoA:
undetectable		 4ffwA-5ljoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr5 GDNF FAMILY RECEPTOR
ALPHA-2

(Homo sapiens) 		no annotation 3 PHE C 208
TYR C 309
TYR C 297
 None
 1.08A 4ffwA-5mr5C:
undetectable		 4ffwA-5mr5C:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ner O PANASIA VP2

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 PHE 2  62
TYR 2 171
TYR 2  91
 None
 1.00A 4ffwA-5ner2:
undetectable		 4ffwA-5ner2:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t88 PROLYL ENDOPEPTIDASE

(Pyrococcus
furiosus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 PHE A 533
TYR A 522
TYR A 537
 None
 1.02A 4ffwA-5t88A:
23.8		 4ffwA-5t88A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvb CHITINASE

(Ostrinia
furnacalis) 		no annotation 3 PHE A 440
TYR A 367
TYR A 377
 None
 1.02A 4ffwA-5wvbA:
undetectable		 4ffwA-5wvbA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN

(Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc) 		3 PHE A1244
TYR A1220
TYR A1241
 None
 1.02A 4ffwA-5xsyA:
undetectable		 4ffwA-5xsyA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y29 INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 3 PHE A1670
TYR A1631
TYR A1618
 None
 1.06A 4ffwA-5y29A:
undetectable		 4ffwA-5y29A:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2a INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 3 PHE A2117
TYR A2077
TYR A2064
 None
 1.02A 4ffwA-5y2aA:
undetectable		 4ffwA-5y2aA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6am0 KLLA0A01474P
KLLA0F23980P

(Kluyveromyces
lactis) 		no annotation 3 PHE A  95
TYR C 359
TYR A  98
 None
 0.96A 4ffwA-6am0A:
undetectable		 4ffwA-6am0A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwf -

(-) 		no annotation 3 PHE A 593
TYR A 524
TYR A 619
 None
 1.08A 4ffwA-6bwfA:
undetectable		 4ffwA-6bwfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9e CYSTEINE DESULFURASE

(Legionella
pneumophila) 		no annotation 3 PHE A  87
TYR A 180
TYR A 228
 None
 1.06A 4ffwA-6c9eA:
undetectable		 4ffwA-6c9eA:
7.53