SIMILAR PATTERNS OF AMINO ACIDS FOR 4FEW_B_KANB301_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cvm | PHYTASE (Bacillusamyloliquefaciens) |
PF02333(Phytase) | 4 | ASP A 52ASN A 99GLU A 157ASP A 314 | CD A 814 (-3.9A) CD A 813 ( 4.1A)None CD A 814 (-2.6A) | 1.21A | 4fewB-1cvmA:undetectable | 4fewB-1cvmA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iv8 | MALTOOLIGOSYLTREHALOSE SYNTHASE (Sulfolobusacidocaldarius) |
PF00128(Alpha-amylase)PF09196(DUF1953) | 4 | ASP A 228ASP A 596ASP A 443GLU A 255 | NoneMLZ A 513 ( 4.9A)NoneNone | 1.16A | 4fewB-1iv8A:undetectable | 4fewB-1iv8A:16.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j5s | URONATE ISOMERASE (Thermotogamaritima) |
PF02614(UxaC) | 4 | ASP A 370ASP A 55ASN A 95GLU A 99 | None | 1.09A | 4fewB-1j5sA:0.3 | 4fewB-1j5sA:20.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1l8t | AMINOGLYCOSIDE3'-PHOSPHOTRANSFERASE (Enterococcusfaecalis) |
PF01636(APH) | 4 | ASP A 190GLU A 230ASP A 261GLU A 262 | KAN A 1 (-3.2A)KAN A 1 (-2.8A)KAN A 1 (-3.8A)KAN A 1 (-3.1A) | 0.53A | 4fewB-1l8tA:27.5 | 4fewB-1l8tA:31.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nd4 | AMINOGLYCOSIDE3'-PHOSPHOTRANSFERASE (Klebsiellapneumoniae) |
PF01636(APH) | 5 | ASP A 157ASP A 159ASP A 190ASP A 261GLU A 262 | KAN A1300 (-3.7A)KAN A1300 (-3.2A)KAN A1300 ( 2.8A)KAN A1300 (-3.8A)KAN A1300 (-3.1A) | 0.30A | 4fewB-1nd4A:31.5 | 4fewB-1nd4A:33.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nd4 | AMINOGLYCOSIDE3'-PHOSPHOTRANSFERASE (Klebsiellapneumoniae) |
PF01636(APH) | 5 | ASP A 157ASP A 159GLU A 230ASP A 261GLU A 262 | KAN A1300 (-3.7A)KAN A1300 (-3.2A)KAN A1300 (-4.1A)KAN A1300 (-3.8A)KAN A1300 (-3.1A) | 0.79A | 4fewB-1nd4A:31.5 | 4fewB-1nd4A:33.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nnh | ASPARAGINYL-TRNASYNTHETASE-RELATEDPEPTIDE (Pyrococcusfuriosus) |
PF00152(tRNA-synt_2) | 4 | ASP A 195ASP A 52ASP A 118GLU A 192 | None | 1.14A | 4fewB-1nnhA:0.0 | 4fewB-1nnhA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p43 | ENOLASE 1 (Saccharomycescerevisiae) |
PF00113(Enolase_C)PF03952(Enolase_N) | 4 | ASP A 320ASN A 347GLU A 47GLU A 377 | MG A 438 ( 3.1A)NoneNoneNone | 1.22A | 4fewB-1p43A:undetectable | 4fewB-1p43A:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pu7 | 3-METHYLADENINE DNAGLYCOSYLASE (Helicobacterpylori) |
PF00633(HHH)PF00730(HhH-GPD) | 4 | ASP A 135ASP A 166GLU A 121GLU A 175 | None | 1.18A | 4fewB-1pu7A:undetectable | 4fewB-1pu7A:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r6b | CLPA PROTEIN (Escherichiacoli) |
PF00004(AAA)PF02861(Clp_N)PF07724(AAA_2)PF10431(ClpB_D2-small) | 4 | ASP X 285ASP X 396GLU X 225GLU X 286 | MG X 782 (-3.7A)ADP X 780 (-4.1A)None MG X 782 ( 4.4A) | 0.84A | 4fewB-1r6bX:0.0 | 4fewB-1r6bX:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ut9 | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Ruminiclostridiumthermocellum) |
PF00759(Glyco_hydro_9)PF02927(CelD_N) | 4 | ASP A 264ASN A 656GLU A 655GLU A 670 | None | 1.21A | 4fewB-1ut9A:undetectable | 4fewB-1ut9A:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ux6 | THROMBOSPONDIN-1 (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C) | 4 | ASP A 874ASP A 870ASP A 890ASN A 882 | None CA A2007 ( 2.8A) CA A2005 ( 2.2A) CA A2006 (-2.8A) | 1.21A | 4fewB-1ux6A:undetectable | 4fewB-1ux6A:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ux6 | THROMBOSPONDIN-1 (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C) | 4 | ASP A 933ASP A 868ASN A 855ASP A 874 | None CA A2007 ( 2.7A)NoneNone | 1.16A | 4fewB-1ux6A:undetectable | 4fewB-1ux6A:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wxf | NH(3)-DEPENDENTNAD(+) SYNTHETASE (Escherichiacoli) |
PF02540(NAD_synthase) | 4 | ASP A 52ASP A 161ASP A 235GLU A 165 | None | 1.11A | 4fewB-1wxfA:undetectable | 4fewB-1wxfA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2akz | GAMMA ENOLASE (Homo sapiens) |
PF00113(Enolase_C)PF03952(Enolase_N) | 4 | ASP A 317ASN A 344GLU A 47GLU A 374 | MG A 440 (-3.0A)NoneNoneNone | 1.22A | 4fewB-2akzA:undetectable | 4fewB-2akzA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b4v | RNA EDITING COMPLEXPROTEIN MP57 (Trypanosomabrucei) |
PF01909(NTP_transf_2)PF03828(PAP_assoc) | 4 | ASP A 421ASP A 99ASN A 277GLU A 424 | None | 1.22A | 4fewB-2b4vA:undetectable | 4fewB-2b4vA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dbn | HYPOTHETICAL PROTEINYBIU (Escherichiacoli) |
PF07350(DUF1479) | 4 | ASP A 116ASN A 113GLU A 397ASP A 111 | None | 1.12A | 4fewB-2dbnA:undetectable | 4fewB-2dbnA:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f6d | GLUCOAMYLASE GLU1 (Saccharomycopsisfibuligera) |
PF00723(Glyco_hydro_15) | 4 | ASP A 349ASP A 207GLU A 456ASP A 288 | NoneNoneACR A 995 ( 4.6A)None | 1.06A | 4fewB-2f6dA:undetectable | 4fewB-2f6dA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i2x | METHYLTRANSFERASE 1 (Methanosarcinabarkeri) |
PF12176(MtaB) | 4 | ASN A 224GLU A 313ASP A 219GLU A 272 | None K A 511 (-3.6A)NoneNone | 1.10A | 4fewB-2i2xA:undetectable | 4fewB-2i2xA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k0z | UNCHARACTERIZEDPROTEIN HP1203 (Helicobacterpylori) |
PF00581(Rhodanese) | 4 | ASP A 43ASN A 42GLU A 24GLU A 45 | None | 0.97A | 4fewB-2k0zA:undetectable | 4fewB-2k0zA:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nli | LACTATE OXIDASE (Aerococcusviridans) |
PF01070(FMN_dh) | 4 | ASP A 24ASP A 55ASN A 21GLU A 27 | None | 1.21A | 4fewB-2nliA:undetectable | 4fewB-2nliA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o3b | NUCLEASESUGAR-NON-SPECIFICNUCLEASE INHIBITOR (Nostoc sp. PCC7120) |
PF01223(Endonuclease_NS)PF07924(NuiA) | 4 | ASP A 153ASN A 157GLU B 111GLU A 233 | None | 1.11A | 4fewB-2o3bA:undetectable | 4fewB-2o3bA:23.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o5p | FERRIPYOVERDINERECEPTOR (Pseudomonasaeruginosa) |
PF00593(TonB_dep_Rec)PF07660(STN)PF07715(Plug) | 4 | ASP A 803ASP A 187ASP A 203ASN A 184 | NonePO4 A 3 (-4.0A)NonePO4 A 3 (-3.4A) | 1.21A | 4fewB-2o5pA:undetectable | 4fewB-2o5pA:15.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2otd | GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE (Shigellaflexneri) |
PF03009(GDPD) | 4 | ASP A 41ASP A 235ASN A 22GLU A 114 | PO4 A 301 (-3.8A)NoneNonePO4 A 301 (-3.4A) | 1.22A | 4fewB-2otdA:undetectable | 4fewB-2otdA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ptz | ENOLASE (Trypanosomabrucei) |
PF00113(Enolase_C)PF03952(Enolase_N) | 4 | ASP A 318ASN A 345GLU A 48GLU A 375 | ZN A 500 ( 3.0A)NoneNoneNone | 1.21A | 4fewB-2ptzA:undetectable | 4fewB-2ptzA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pz8 | NH(3)-DEPENDENTNAD(+) SYNTHETASE (Bacillusanthracis) |
PF02540(NAD_synthase) | 4 | ASP A 51ASP A 159ASP A 233GLU A 163 | APC A3001 (-3.7A)NoneNoneAPC A3001 ( 4.6A) | 1.10A | 4fewB-2pz8A:undetectable | 4fewB-2pz8A:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rhp | THROMBOSPONDIN-2 (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C)PF07645(EGF_CA)PF12947(EGF_3) | 4 | ASP A 738ASP A 734ASP A 754ASN A 746 | None CA A 26 ( 2.8A) CA A 23 ( 2.3A) CA A 26 (-2.7A) | 1.16A | 4fewB-2rhpA:undetectable | 4fewB-2rhpA:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rhp | THROMBOSPONDIN-2 (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C)PF07645(EGF_CA)PF12947(EGF_3) | 4 | ASP A 894ASP A 890ASP A 910ASN A 902 | None CA A 7 ( 2.5A) CA A1175 ( 2.5A) CA A1176 (-3.1A) | 1.19A | 4fewB-2rhpA:undetectable | 4fewB-2rhpA:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vn7 | GLUCOAMYLASE (Trichodermareesei) |
PF00686(CBM_20)PF00723(Glyco_hydro_15) | 4 | ASP A 313ASP A 176GLU A 404ASP A 249 | NoneNoneBTB A 620 (-4.0A)None | 0.93A | 4fewB-2vn7A:undetectable | 4fewB-2vn7A:16.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wba | TRYPANOTHIONEREDUCTASE (Trypanosomabrucei) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | ASP A 432ASP A 71ASN A 245GLU A 75 | None | 1.01A | 4fewB-2wbaA:undetectable | 4fewB-2wbaA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xhe | UNC18 (Monosigabrevicollis) |
PF00995(Sec1) | 4 | ASP A 56ASP A 30ASP A 86ASN A 79 | None | 0.95A | 4fewB-2xheA:undetectable | 4fewB-2xheA:16.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yeq | ALKALINE PHOSPHATASED (Bacillussubtilis) |
PF09423(PhoD)PF16655(PhoD_N) | 4 | ASP A 289ASP A 380GLU A 504GLU A 223 | None CA A1525 ( 3.4A)EDO A 540 (-3.7A)None | 1.22A | 4fewB-2yeqA:undetectable | 4fewB-2yeqA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ynk | WZI (Escherichiacoli) |
PF14052(Caps_assemb_Wzi) | 4 | ASP A 30ASP A 36ASP A 441GLU A 396 | None | 1.21A | 4fewB-2ynkA:undetectable | 4fewB-2ynkA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2m | PENICILLIN-BINDINGPROTEIN 2X (Streptococcuspneumoniae) |
PF03717(PBP_dimer) | 4 | ASP A 208ASN A 206GLU A 205ASP A 231 | None | 1.18A | 4fewB-2z2mA:undetectable | 4fewB-2z2mA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z5l | TYLACTONE SYNTHASESTARTER MODULE ANDMODULES 1 & 2 (Streptomycesfradiae) |
PF08659(KR) | 4 | ASP A 326ASN A 377GLU A 154GLU A 423 | None | 1.08A | 4fewB-2z5lA:undetectable | 4fewB-2z5lA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zuy | YESX PROTEIN (Bacillussubtilis) |
PF01839(FG-GAP) | 4 | ASP A 125ASP A 191GLU A 241ASP A 189 | CA A 623 (-3.2A) CA A 624 (-2.9A)None CA A 624 (-3.2A) | 1.13A | 4fewB-2zuyA:undetectable | 4fewB-2zuyA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cc1 | PUTATIVEALPHA-N-ACETYLGALACTOSAMINIDASE (Bacillushalodurans) |
PF16499(Melibiase_2) | 4 | ASP A 285ASP A 19ASP A 183ASP A 52 | NoneNoneIMD A 437 ( 3.8A)IMD A 437 (-3.3A) | 1.21A | 4fewB-3cc1A:undetectable | 4fewB-3cc1A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dpr | LDL-RECEPTOR CLASS A3 (Homo sapiens) |
PF00057(Ldl_recept_a) | 4 | ASP E 35ASN E 28GLU E 27ASP E 31 | CA E 50 (-3.5A)NoneNoneNone | 1.15A | 4fewB-3dprE:undetectable | 4fewB-3dprE:9.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egw | RESPIRATORY NITRATEREDUCTASE 1 ALPHACHAINRESPIRATORY NITRATEREDUCTASE 1 BETACHAIN (Escherichiacoli) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF13247(Fer4_11)PF14710(Nitr_red_alph_N)PF14711(Nitr_red_bet_C) | 4 | ASP A 33ASP B 482ASP B 500GLU B 472 | None | 1.11A | 4fewB-3egwA:undetectable | 4fewB-3egwA:12.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eqa | GLUCOAMYLASE (Aspergillusniger) |
PF00723(Glyco_hydro_15) | 4 | ASP A 333ASP A 200GLU A 424ASP A 269 | None | 0.99A | 4fewB-3eqaA:undetectable | 4fewB-3eqaA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g1n | E3 UBIQUITIN-PROTEINLIGASE HUWE1 (Homo sapiens) |
PF00632(HECT) | 4 | ASP A4087GLU A4248ASP A4145GLU A4149 | NA A5001 (-3.4A)NoneNoneNone | 1.16A | 4fewB-3g1nA:undetectable | 4fewB-3g1nA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h4x | PHOSPHATIDYLINOSITOL-SPECIFICPHOSPHOLIPASE C1 (Streptomycesantibioticus) |
PF16670(PI-PLC-C1) | 4 | ASP A 62ASP A 287ASN A 38GLU A 129 | NoneEOH A 348 ( 4.5A)NoneNone | 0.90A | 4fewB-3h4xA:undetectable | 4fewB-3h4xA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h4x | PHOSPHATIDYLINOSITOL-SPECIFICPHOSPHOLIPASE C1 (Streptomycesantibioticus) |
PF16670(PI-PLC-C1) | 4 | ASP A 62ASP A 287GLU A 41GLU A 129 | NoneEOH A 348 ( 4.5A)NoneNone | 0.96A | 4fewB-3h4xA:undetectable | 4fewB-3h4xA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h7n | NUCLEOPORIN NUP120 (Saccharomycescerevisiae) |
PF11715(Nup160) | 4 | ASP A 8ASN A 383ASP A 388GLU A 392 | None | 1.05A | 4fewB-3h7nA:undetectable | 4fewB-3h7nA:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hdb | AAHIV (Deinagkistrodonacutus) |
PF00200(Disintegrin)PF01421(Reprolysin)PF08516(ADAM_CR) | 4 | ASP A 416ASN A 229GLU A 233GLU A 410 | CA A 622 (-3.3A)2PE A 652 (-3.5A)2PE A 652 (-4.1A) CA A 622 (-3.3A) | 1.21A | 4fewB-3hdbA:undetectable | 4fewB-3hdbA:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hmq | NH(3)-DEPENDENTNAD(+) SYNTHETASE (Salmonellaenterica) |
PF02540(NAD_synthase) | 4 | ASP A 52ASP A 161ASP A 235GLU A 165 | SO4 A 276 (-4.9A)NoneNoneNone | 1.06A | 4fewB-3hmqA:undetectable | 4fewB-3hmqA:25.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hwc | CHLOROPHENOL-4-MONOOXYGENASE COMPONENT 2 (Burkholderiacepacia) |
PF03241(HpaB)PF11794(HpaB_N) | 4 | ASP A3461ASP A3286ASN A3358ASP A3363 | None | 1.21A | 4fewB-3hwcA:undetectable | 4fewB-3hwcA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ks5 | GLYCEROPHOSPHORYLDIESTERPHOSPHODIESTERASE (Agrobacteriumfabrum) |
PF03009(GDPD) | 4 | ASP A 36ASP A 50ASP A 231ASP A 16 | FE A 250 (-2.6A)EDO A 256 (-3.0A)NoneEDO A 256 (-3.5A) | 1.11A | 4fewB-3ks5A:undetectable | 4fewB-3ks5A:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l12 | PUTATIVEGLYCEROPHOSPHORYLDIESTERPHOSPHODIESTERASE (Ruegeriapomeroyi) |
PF03009(GDPD) | 4 | ASP A 51ASP A 295ASN A 32GLU A 148 | MG A 313 (-2.6A)NoneNone MG A 313 (-2.9A) | 1.23A | 4fewB-3l12A:undetectable | 4fewB-3l12A:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3no3 | GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE (Parabacteroidesdistasonis) |
PF03009(GDPD) | 4 | ASP A 61ASP A 244ASN A 42GLU A 123 | MG A 301 (-2.5A)NoneNone MG A 301 ( 2.8A) | 1.21A | 4fewB-3no3A:undetectable | 4fewB-3no3A:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nqx | SECRETEDMETALLOPROTEASEMCP02 (Pseudoalteromonassp. SM9913) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 4 | ASP A 411ASN A 435GLU A 377GLU A 369 | NoneNone CA A 511 (-2.7A) ZN A 1 (-2.3A) | 1.21A | 4fewB-3nqxA:undetectable | 4fewB-3nqxA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o8o | 6-PHOSPHOFRUCTOKINASE SUBUNIT BETA (Saccharomycescerevisiae) |
PF00365(PFK) | 4 | ASN B 524GLU B 725ASP B 355GLU B 560 | None | 1.17A | 4fewB-3o8oB:undetectable | 4fewB-3o8oB:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p8t | ASNS-LIKEASPARAGINYL-TRNASYNTHETASE RELATEDPROTEIN (Pyrococcusabyssi) |
PF00152(tRNA-synt_2) | 4 | ASP A 195ASP A 52ASP A 118GLU A 192 | None | 1.12A | 4fewB-3p8tA:undetectable | 4fewB-3p8tA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qo7 | SERYL-TRNASYNTHETASE,CYTOPLASMIC (Candidaalbicans) |
PF00587(tRNA-synt_2b)PF02403(Seryl_tRNA_N) | 4 | ASN A 125GLU A 355ASP A 121GLU A 343 | None | 1.21A | 4fewB-3qo7A:undetectable | 4fewB-3qo7A:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s83 | GGDEF FAMILY PROTEIN (Caulobactervibrioides) |
PF00563(EAL) | 4 | ASP A 469ASP A 446ASP A 339GLU A 503 | None K A 549 (-3.4A)None K A 549 ( 4.7A) | 1.15A | 4fewB-3s83A:undetectable | 4fewB-3s83A:24.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t0p | DNA POLYMERASE III,BETA SUBUNIT ([Eubacterium]rectale) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 4 | ASP A 352ASP A 311ASN A 337GLU A 335 | None | 0.78A | 4fewB-3t0pA:undetectable | 4fewB-3t0pA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v0a | NTNH (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07953(Toxin_R_bind_N)PF08470(NTNH_C) | 4 | ASP B 479ASP B 190ASN B 193GLU B 192 | None | 1.21A | 4fewB-3v0aB:1.9 | 4fewB-3v0aB:11.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vv3 | DESEASIN MCP-01 (Pseudoalteromonassp. SM9913) |
PF00082(Peptidase_S8) | 4 | ASP A 303ASN A 16GLU A 17ASP A 231 | None | 1.15A | 4fewB-3vv3A:undetectable | 4fewB-3vv3A:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vvl | HOMOSERINEO-ACETYLTRANSFERASE (Streptomyceslavendulae) |
PF00561(Abhydrolase_1) | 4 | ASP A 65GLU A 72ASP A 56GLU A 34 | None | 1.13A | 4fewB-3vvlA:undetectable | 4fewB-3vvlA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wjo | OCTAPRENYLDIPHOSPHATE SYNTHASE (Escherichiacoli) |
PF00348(polyprenyl_synt) | 4 | ASP A 88ASP A 211ASP A 230GLU A 233 | IPE A 401 (-3.3A)IPE A 402 ( 4.6A)NoneNone | 0.97A | 4fewB-3wjoA:undetectable | 4fewB-3wjoA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wrf | NON-REDUCING ENDBETA-L-ARABINOFURANOSIDASE (Bifidobacteriumlongum) |
PF07944(Glyco_hydro_127) | 4 | ASP A 77ASN A 421GLU A 338GLU A 196 | None | 1.21A | 4fewB-3wrfA:undetectable | 4fewB-3wrfA:17.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a01 | PROTONPYROPHOSPHATASE (Vigna radiata) |
PF03030(H_PPase) | 4 | ASP A 257ASP A 269ASP A 287ASN A 280 | MG A1767 (-2.5A) MG A1768 ( 3.9A)2PN A1773 (-3.9A) MG A1768 ( 4.9A) | 1.13A | 4fewB-4a01A:0.7 | 4fewB-4a01A:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a01 | PROTONPYROPHOSPHATASE (Vigna radiata) |
PF03030(H_PPase) | 4 | ASP A 691ASP A 727ASP A 269ASP A 257 | MG A1771 ( 2.7A) MG A1769 ( 2.5A) MG A1768 ( 3.9A) MG A1767 (-2.5A) | 0.89A | 4fewB-4a01A:0.7 | 4fewB-4a01A:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bil | DNA MATURASE B (Escherichiavirus T7) |
no annotation | 4 | ASP A 262ASP A 250GLU A 232GLU A 254 | None | 1.12A | 4fewB-4bilA:undetectable | 4fewB-4bilA:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e2o | ALPHA-AMYLASE (Geobacillusthermoleovorans) |
PF00128(Alpha-amylase) | 4 | ASP A 463ASN A 437ASP A 458GLU A 459 | None | 1.22A | 4fewB-4e2oA:undetectable | 4fewB-4e2oA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f7k | LACCASE (unculturedbacterium) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | ASP A 150ASP A 152ASN A 289ASP A 260 | None | 1.13A | 4fewB-4f7kA:undetectable | 4fewB-4f7kA:21.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4gkh | AMINOGLYCOSIDE3'-PHOSPHOTRANSFERASE APHA1-IAB (Acinetobacterbaumannii) |
PF01636(APH) | 7 | ASP A 165ASP A 167ASP A 198ASN A 234GLU A 238ASP A 268GLU A 269 | KAN A 301 (-3.7A)KAN A 301 (-3.3A)KAN A 301 (-3.0A)KAN A 301 (-3.9A)NoneKAN A 301 (-3.8A)KAN A 301 (-3.2A) | 0.62A | 4fewB-4gkhA:39.6 | 4fewB-4gkhA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gp1 | POLYPRENYLSYNTHETASE (Pyrobaculumcalidifontis) |
PF00348(polyprenyl_synt) | 4 | ASP A 226GLU A 148ASP A 244GLU A 247 | None | 0.97A | 4fewB-4gp1A:undetectable | 4fewB-4gp1A:22.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4h05 | AMINOGLYCOSIDE-O-PHOSPHOTRANSFERASE VIII (Streptomycesrimosus) |
PF01636(APH) | 4 | ASP A 153ASP A 184ASP A 264GLU A 265 | None | 0.45A | 4fewB-4h05A:29.7 | 4fewB-4h05A:34.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h1s | 5'-NUCLEOTIDASE (Homo sapiens) |
PF00149(Metallophos)PF02872(5_nucleotid_C) | 4 | ASP A 47ASN A 410GLU A 409ASP A 399 | None | 1.17A | 4fewB-4h1sA:undetectable | 4fewB-4h1sA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hly | K9 (Humangammaherpesvirus8) |
PF00605(IRF) | 4 | ASP A 98GLU A 23ASP A 49GLU A 45 | None | 1.22A | 4fewB-4hlyA:undetectable | 4fewB-4hlyA:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jcl | CYCLOMALTODEXTRINGLUCANOTRANSFERASE (Paenibacillusmacerans) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG) | 4 | ASP A 59ASP A 53ASN A 32ASP A 117 | EDO A 726 ( 4.9A) CA A 701 (-3.3A) CA A 701 (-3.2A)GOL A 717 (-2.9A) | 1.22A | 4fewB-4jclA:undetectable | 4fewB-4jclA:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jlw | GLUTATHIONE-INDEPENDENT FORMALDEHYDEDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | ASP A 355ASP A 164GLU A 160ASP A 361 | None | 1.16A | 4fewB-4jlwA:undetectable | 4fewB-4jlwA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kc5 | RHIE PROTEIN (Paraburkholderiarhizoxinica) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 4 | ASP A3183ASP A3225ASN A3256GLU A3143 | None | 1.19A | 4fewB-4kc5A:undetectable | 4fewB-4kc5A:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nzj | PUTATIVEALPHA-GALACTOSIDASE (Bacteroidesfragilis) |
PF05345(He_PIG)PF10632(He_PIG_assoc)PF16499(Melibiase_2) | 4 | ASP A 243ASP A 165ASP A 340ASN A 128 | GOL A 600 (-3.6A)GOL A 600 (-3.2A)NoneNone | 1.17A | 4fewB-4nzjA:undetectable | 4fewB-4nzjA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qlz | SJCHGC07024 PROTEIN (Schistosomajaponicum) |
PF00719(Pyrophosphatase) | 4 | ASP A 118GLU A 60ASP A 113GLU A 148 | CO A 401 (-2.5A)None CO A 401 ( 2.8A)None | 1.21A | 4fewB-4qlzA:undetectable | 4fewB-4qlzA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uxv | SEPTATION RINGFORMATION REGULATOREZRA (Bacillussubtilis) |
PF06160(EzrA) | 4 | ASP A 88ASP A 109ASN A 102ASP A 30 | None | 0.87A | 4fewB-4uxvA:undetectable | 4fewB-4uxvA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xfd | NH(3)-DEPENDENTNAD(+) SYNTHETASE (Pseudomonasaeruginosa) |
PF02540(NAD_synthase) | 4 | ASP A 56ASP A 168ASP A 242GLU A 172 | None | 1.05A | 4fewB-4xfdA:undetectable | 4fewB-4xfdA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgi | GLUTAMATEDEHYDROGENASE (Burkholderiathailandensis) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 4 | ASP A 96ASP A 22GLU A 74GLU A 101 | None | 1.16A | 4fewB-4xgiA:undetectable | 4fewB-4xgiA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b1u | METALLO-BETA-LACTAMASE (Serratiamarcescens) |
PF00753(Lactamase_B) | 4 | ASP A 76ASP A 174GLU A 217ASP A 41 | ZN A 302 ( 2.5A)NoneHIW A 321 ( 4.6A)None | 1.14A | 4fewB-5b1uA:undetectable | 4fewB-5b1uA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dzv | PROTEIN PCDHA7 (Mus musculus) |
PF00028(Cadherin)PF08266(Cadherin_2) | 4 | ASP A 454ASP A 333ASN A 420GLU A 457 | CA A 612 (-3.0A)None CA A 612 (-3.5A)None | 1.13A | 4fewB-5dzvA:undetectable | 4fewB-5dzvA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dzv | PROTEIN PCDHA7 (Mus musculus) |
PF00028(Cadherin)PF08266(Cadherin_2) | 4 | ASP A 454ASP A 333GLU A 457GLU A 387 | CA A 612 (-3.0A)NoneNone CA A 611 ( 2.8A) | 1.17A | 4fewB-5dzvA:undetectable | 4fewB-5dzvA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fbb | NUCLEASE S1 (Aspergillusoryzae) |
PF02265(S1-P1_nuclease) | 4 | ASP A 139ASN A 23GLU A 177ASP A 65 | ZN A 402 (-2.5A)BTB A1002 (-3.8A)BTB A1002 (-2.8A)PO4 A 601 ( 2.7A) | 1.11A | 4fewB-5fbbA:undetectable | 4fewB-5fbbA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fqe | BETA-N-ACETYLGALACTOSAMINIDASE (Clostridiumperfringens) |
PF13320(DUF4091) | 4 | ASP A 404ASN A 452GLU A 415GLU A 531 | None | 1.17A | 4fewB-5fqeA:undetectable | 4fewB-5fqeA:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h9d | FARNESYLPYROPHOSPHATESYNTHETASE (Staphylococcusaureus) |
PF00348(polyprenyl_synt) | 4 | ASP A 86ASP A 210GLU A 144ASP A 228 | None | 1.15A | 4fewB-5h9dA:undetectable | 4fewB-5h9dA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ic5 | CANDIDATE RESPONSEREGULATOR, CHEY (Ramlibactertataouinensis) |
PF00072(Response_reg) | 4 | ASP A 64GLU A 99ASP A 11GLU A 9 | MG A 204 (-2.8A)NoneNone MG A 204 ( 4.2A) | 1.09A | 4fewB-5ic5A:undetectable | 4fewB-5ic5A:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iqk | BETA-LACTAMASE RM3 (unculturedbacterium) |
PF00753(Lactamase_B) | 4 | ASP A 112ASP A 210GLU A 256ASP A 77 | ZN A 402 (-2.4A)NoneNoneNone | 1.07A | 4fewB-5iqkA:undetectable | 4fewB-5iqkA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iry | DESMOCOLLIN-1 (Homo sapiens) |
PF00028(Cadherin) | 4 | ASP A 348ASP A 516ASP A 465GLU A 402 | CA A 609 ( 3.1A) CA A 611 (-3.0A) CA A 610 ( 3.8A) CA A 609 ( 2.1A) | 0.97A | 4fewB-5iryA:undetectable | 4fewB-5iryA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kzn | METABOTROPICGLUTAMATE RECEPTOR 2 (Homo sapiens) |
PF01094(ANF_receptor)PF07562(NCD3G) | 4 | ASP A 188GLU A 375ASP A 295GLU A 318 | None | 1.22A | 4fewB-5kznA:undetectable | 4fewB-5kznA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o9g | CHROMODOMAIN-CONTAININGPROTEIN 1 (Saccharomycescerevisiae) |
no annotation | 4 | ASP W 464ASP W 317ASP W 498ASN W 459 | None | 1.16A | 4fewB-5o9gW:undetectable | 4fewB-5o9gW:11.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ucm | PROLINE--TRNA LIGASE (Pseudomonasaeruginosa) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF04073(tRNA_edit) | 4 | ASP A 356ASN A 372ASP A 251GLU A 250 | None | 1.14A | 4fewB-5ucmA:3.6 | 4fewB-5ucmA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vis | DIHYDROPTEROATESYNTHASE (soil metagenome) |
PF00809(Pterin_bind) | 4 | ASP A 106ASP A 86ASP A 136GLU A 63 | None | 1.12A | 4fewB-5visA:undetectable | 4fewB-5visA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wzr | ALPHA-N-ACETYLGALACTOSAMINIDASE (Bifidobacteriumbifidum) |
PF11308(Glyco_hydro_129) | 4 | ASP A 561ASP A 322ASP A 371ASP A 330 | DJN A 702 (-2.9A) CA A 703 (-2.1A)DJN A 702 (-3.1A)DJN A 702 (-2.6A) | 1.17A | 4fewB-5wzrA:undetectable | 4fewB-5wzrA:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yz0 | SERINE/THREONINE-PROTEIN KINASE ATR (Homo sapiens) |
no annotation | 4 | ASP A2330ASP A2335ASP A2475ASP A2494 | None | 1.21A | 4fewB-5yz0A:3.6 | 4fewB-5yz0A:17.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zal | ENDORIBONUCLEASEDICER (Homo sapiens) |
no annotation | 4 | ASP A1810ASN A1742ASP A1709GLU A1705 | None | 0.96A | 4fewB-5zalA:undetectable | 4fewB-5zalA:13.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c8q | NH(3)-DEPENDENTNAD(+) SYNTHETASE (Enterococcusfaecalis) |
no annotation | 4 | ASP A 53ASP A 162ASP A 236GLU A 166 | None | 1.13A | 4fewB-6c8qA:undetectable | 4fewB-6c8qA:15.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cey | BIFUNCTIONAL AAC/APH (Staphylococcusaureus) |
no annotation | 4 | ASP A 396ASP A 393ASP A 213GLU A 240 | MG A 702 ( 4.8A) MG A 702 (-1.7A)NoneGNP A 500 ( 4.4A) | 1.19A | 4fewB-6ceyA:17.8 | 4fewB-6ceyA:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fhv | GLUCOAMYLASE (Penicilliumoxalicum) |
no annotation | 4 | ASP A 345ASP A 210GLU A 436ASP A 281 | NoneNoneB3P A 652 ( 4.6A)None | 0.97A | 4fewB-6fhvA:undetectable | 4fewB-6fhvA:12.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fhw | GLUCOAMYLASE P (Amorphothecaresinae) |
no annotation | 4 | ASP A 339ASP A 205GLU A 432ASP A 275 | NoneNoneACR A 801 (-4.4A)None | 1.06A | 4fewB-6fhwA:undetectable | 4fewB-6fhwA:15.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6frv | GLUCOAMYLASE (Aspergillusniger) |
no annotation | 4 | ASP A 333ASP A 200GLU A 424ASP A 269 | None | 1.05A | 4fewB-6frvA:undetectable | 4fewB-6frvA:17.58 |