SIMILAR PATTERNS OF AMINO ACIDS FOR 4FEW_B_KANB301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvm PHYTASE

(Bacillus
amyloliquefaciens)
PF02333
(Phytase)
4 ASP A  52
ASN A  99
GLU A 157
ASP A 314
CD  A 814 (-3.9A)
CD  A 813 ( 4.1A)
None
CD  A 814 (-2.6A)
1.21A 4fewB-1cvmA:
undetectable
4fewB-1cvmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE


(Sulfolobus
acidocaldarius)
PF00128
(Alpha-amylase)
PF09196
(DUF1953)
4 ASP A 228
ASP A 596
ASP A 443
GLU A 255
None
MLZ  A 513 ( 4.9A)
None
None
1.16A 4fewB-1iv8A:
undetectable
4fewB-1iv8A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5s URONATE ISOMERASE

(Thermotoga
maritima)
PF02614
(UxaC)
4 ASP A 370
ASP A  55
ASN A  95
GLU A  99
None
1.09A 4fewB-1j5sA:
0.3
4fewB-1j5sA:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1l8t AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E


(Enterococcus
faecalis)
PF01636
(APH)
4 ASP A 190
GLU A 230
ASP A 261
GLU A 262
KAN  A   1 (-3.2A)
KAN  A   1 (-2.8A)
KAN  A   1 (-3.8A)
KAN  A   1 (-3.1A)
0.53A 4fewB-1l8tA:
27.5
4fewB-1l8tA:
31.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nd4 AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E


(Klebsiella
pneumoniae)
PF01636
(APH)
5 ASP A 157
ASP A 159
ASP A 190
ASP A 261
GLU A 262
KAN  A1300 (-3.7A)
KAN  A1300 (-3.2A)
KAN  A1300 ( 2.8A)
KAN  A1300 (-3.8A)
KAN  A1300 (-3.1A)
0.30A 4fewB-1nd4A:
31.5
4fewB-1nd4A:
33.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nd4 AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E


(Klebsiella
pneumoniae)
PF01636
(APH)
5 ASP A 157
ASP A 159
GLU A 230
ASP A 261
GLU A 262
KAN  A1300 (-3.7A)
KAN  A1300 (-3.2A)
KAN  A1300 (-4.1A)
KAN  A1300 (-3.8A)
KAN  A1300 (-3.1A)
0.79A 4fewB-1nd4A:
31.5
4fewB-1nd4A:
33.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnh ASPARAGINYL-TRNA
SYNTHETASE-RELATED
PEPTIDE


(Pyrococcus
furiosus)
PF00152
(tRNA-synt_2)
4 ASP A 195
ASP A  52
ASP A 118
GLU A 192
None
1.14A 4fewB-1nnhA:
0.0
4fewB-1nnhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
4 ASP A 320
ASN A 347
GLU A  47
GLU A 377
MG  A 438 ( 3.1A)
None
None
None
1.22A 4fewB-1p43A:
undetectable
4fewB-1p43A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pu7 3-METHYLADENINE DNA
GLYCOSYLASE


(Helicobacter
pylori)
PF00633
(HHH)
PF00730
(HhH-GPD)
4 ASP A 135
ASP A 166
GLU A 121
GLU A 175
None
1.18A 4fewB-1pu7A:
undetectable
4fewB-1pu7A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli)
PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small)
4 ASP X 285
ASP X 396
GLU X 225
GLU X 286
MG  X 782 (-3.7A)
ADP  X 780 (-4.1A)
None
MG  X 782 ( 4.4A)
0.84A 4fewB-1r6bX:
0.0
4fewB-1r6bX:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE


(Ruminiclostridium
thermocellum)
PF00759
(Glyco_hydro_9)
PF02927
(CelD_N)
4 ASP A 264
ASN A 656
GLU A 655
GLU A 670
None
1.21A 4fewB-1ut9A:
undetectable
4fewB-1ut9A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens)
PF02412
(TSP_3)
PF05735
(TSP_C)
4 ASP A 874
ASP A 870
ASP A 890
ASN A 882
None
CA  A2007 ( 2.8A)
CA  A2005 ( 2.2A)
CA  A2006 (-2.8A)
1.21A 4fewB-1ux6A:
undetectable
4fewB-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens)
PF02412
(TSP_3)
PF05735
(TSP_C)
4 ASP A 933
ASP A 868
ASN A 855
ASP A 874
None
CA  A2007 ( 2.7A)
None
None
1.16A 4fewB-1ux6A:
undetectable
4fewB-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE


(Escherichia
coli)
PF02540
(NAD_synthase)
4 ASP A  52
ASP A 161
ASP A 235
GLU A 165
None
1.11A 4fewB-1wxfA:
undetectable
4fewB-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akz GAMMA ENOLASE

(Homo sapiens)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
4 ASP A 317
ASN A 344
GLU A  47
GLU A 374
MG  A 440 (-3.0A)
None
None
None
1.22A 4fewB-2akzA:
undetectable
4fewB-2akzA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4v RNA EDITING COMPLEX
PROTEIN MP57


(Trypanosoma
brucei)
PF01909
(NTP_transf_2)
PF03828
(PAP_assoc)
4 ASP A 421
ASP A  99
ASN A 277
GLU A 424
None
1.22A 4fewB-2b4vA:
undetectable
4fewB-2b4vA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbn HYPOTHETICAL PROTEIN
YBIU


(Escherichia
coli)
PF07350
(DUF1479)
4 ASP A 116
ASN A 113
GLU A 397
ASP A 111
None
1.12A 4fewB-2dbnA:
undetectable
4fewB-2dbnA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera)
PF00723
(Glyco_hydro_15)
4 ASP A 349
ASP A 207
GLU A 456
ASP A 288
None
None
ACR  A 995 ( 4.6A)
None
1.06A 4fewB-2f6dA:
undetectable
4fewB-2f6dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri)
PF12176
(MtaB)
4 ASN A 224
GLU A 313
ASP A 219
GLU A 272
None
K  A 511 (-3.6A)
None
None
1.10A 4fewB-2i2xA:
undetectable
4fewB-2i2xA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k0z UNCHARACTERIZED
PROTEIN HP1203


(Helicobacter
pylori)
PF00581
(Rhodanese)
4 ASP A  43
ASN A  42
GLU A  24
GLU A  45
None
0.97A 4fewB-2k0zA:
undetectable
4fewB-2k0zA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nli LACTATE OXIDASE

(Aerococcus
viridans)
PF01070
(FMN_dh)
4 ASP A  24
ASP A  55
ASN A  21
GLU A  27
None
1.21A 4fewB-2nliA:
undetectable
4fewB-2nliA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3b NUCLEASE
SUGAR-NON-SPECIFIC
NUCLEASE INHIBITOR


(Nostoc sp. PCC
7120)
PF01223
(Endonuclease_NS)
PF07924
(NuiA)
4 ASP A 153
ASN A 157
GLU B 111
GLU A 233
None
1.11A 4fewB-2o3bA:
undetectable
4fewB-2o3bA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR


(Pseudomonas
aeruginosa)
PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug)
4 ASP A 803
ASP A 187
ASP A 203
ASN A 184
None
PO4  A   3 (-4.0A)
None
PO4  A   3 (-3.4A)
1.21A 4fewB-2o5pA:
undetectable
4fewB-2o5pA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE


(Shigella
flexneri)
PF03009
(GDPD)
4 ASP A  41
ASP A 235
ASN A  22
GLU A 114
PO4  A 301 (-3.8A)
None
None
PO4  A 301 (-3.4A)
1.22A 4fewB-2otdA:
undetectable
4fewB-2otdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
4 ASP A 318
ASN A 345
GLU A  48
GLU A 375
ZN  A 500 ( 3.0A)
None
None
None
1.21A 4fewB-2ptzA:
undetectable
4fewB-2ptzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE


(Bacillus
anthracis)
PF02540
(NAD_synthase)
4 ASP A  51
ASP A 159
ASP A 233
GLU A 163
APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
1.10A 4fewB-2pz8A:
undetectable
4fewB-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens)
PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3)
4 ASP A 738
ASP A 734
ASP A 754
ASN A 746
None
CA  A  26 ( 2.8A)
CA  A  23 ( 2.3A)
CA  A  26 (-2.7A)
1.16A 4fewB-2rhpA:
undetectable
4fewB-2rhpA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens)
PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3)
4 ASP A 894
ASP A 890
ASP A 910
ASN A 902
None
CA  A   7 ( 2.5A)
CA  A1175 ( 2.5A)
CA  A1176 (-3.1A)
1.19A 4fewB-2rhpA:
undetectable
4fewB-2rhpA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei)
PF00686
(CBM_20)
PF00723
(Glyco_hydro_15)
4 ASP A 313
ASP A 176
GLU A 404
ASP A 249
None
None
BTB  A 620 (-4.0A)
None
0.93A 4fewB-2vn7A:
undetectable
4fewB-2vn7A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wba TRYPANOTHIONE
REDUCTASE


(Trypanosoma
brucei)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 ASP A 432
ASP A  71
ASN A 245
GLU A  75
None
1.01A 4fewB-2wbaA:
undetectable
4fewB-2wbaA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18

(Monosiga
brevicollis)
PF00995
(Sec1)
4 ASP A  56
ASP A  30
ASP A  86
ASN A  79
None
0.95A 4fewB-2xheA:
undetectable
4fewB-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yeq ALKALINE PHOSPHATASE
D


(Bacillus
subtilis)
PF09423
(PhoD)
PF16655
(PhoD_N)
4 ASP A 289
ASP A 380
GLU A 504
GLU A 223
None
CA  A1525 ( 3.4A)
EDO  A 540 (-3.7A)
None
1.22A 4fewB-2yeqA:
undetectable
4fewB-2yeqA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynk WZI

(Escherichia
coli)
PF14052
(Caps_assemb_Wzi)
4 ASP A  30
ASP A  36
ASP A 441
GLU A 396
None
1.21A 4fewB-2ynkA:
undetectable
4fewB-2ynkA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X


(Streptococcus
pneumoniae)
PF03717
(PBP_dimer)
4 ASP A 208
ASN A 206
GLU A 205
ASP A 231
None
1.18A 4fewB-2z2mA:
undetectable
4fewB-2z2mA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5l TYLACTONE SYNTHASE
STARTER MODULE AND
MODULES 1 & 2


(Streptomyces
fradiae)
PF08659
(KR)
4 ASP A 326
ASN A 377
GLU A 154
GLU A 423
None
1.08A 4fewB-2z5lA:
undetectable
4fewB-2z5lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis)
PF01839
(FG-GAP)
4 ASP A 125
ASP A 191
GLU A 241
ASP A 189
CA  A 623 (-3.2A)
CA  A 624 (-2.9A)
None
CA  A 624 (-3.2A)
1.13A 4fewB-2zuyA:
undetectable
4fewB-2zuyA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE


(Bacillus
halodurans)
PF16499
(Melibiase_2)
4 ASP A 285
ASP A  19
ASP A 183
ASP A  52
None
None
IMD  A 437 ( 3.8A)
IMD  A 437 (-3.3A)
1.21A 4fewB-3cc1A:
undetectable
4fewB-3cc1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpr LDL-RECEPTOR CLASS A
3


(Homo sapiens)
PF00057
(Ldl_recept_a)
4 ASP E  35
ASN E  28
GLU E  27
ASP E  31
CA  E  50 (-3.5A)
None
None
None
1.15A 4fewB-3dprE:
undetectable
4fewB-3dprE:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN


(Escherichia
coli)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF13247
(Fer4_11)
PF14710
(Nitr_red_alph_N)
PF14711
(Nitr_red_bet_C)
4 ASP A  33
ASP B 482
ASP B 500
GLU B 472
None
1.11A 4fewB-3egwA:
undetectable
4fewB-3egwA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger)
PF00723
(Glyco_hydro_15)
4 ASP A 333
ASP A 200
GLU A 424
ASP A 269
None
0.99A 4fewB-3eqaA:
undetectable
4fewB-3eqaA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1


(Homo sapiens)
PF00632
(HECT)
4 ASP A4087
GLU A4248
ASP A4145
GLU A4149
NA  A5001 (-3.4A)
None
None
None
1.16A 4fewB-3g1nA:
undetectable
4fewB-3g1nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1


(Streptomyces
antibioticus)
PF16670
(PI-PLC-C1)
4 ASP A  62
ASP A 287
ASN A  38
GLU A 129
None
EOH  A 348 ( 4.5A)
None
None
0.90A 4fewB-3h4xA:
undetectable
4fewB-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1


(Streptomyces
antibioticus)
PF16670
(PI-PLC-C1)
4 ASP A  62
ASP A 287
GLU A  41
GLU A 129
None
EOH  A 348 ( 4.5A)
None
None
0.96A 4fewB-3h4xA:
undetectable
4fewB-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7n NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae)
PF11715
(Nup160)
4 ASP A   8
ASN A 383
ASP A 388
GLU A 392
None
1.05A 4fewB-3h7nA:
undetectable
4fewB-3h7nA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdb AAHIV

(Deinagkistrodon
acutus)
PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR)
4 ASP A 416
ASN A 229
GLU A 233
GLU A 410
CA  A 622 (-3.3A)
2PE  A 652 (-3.5A)
2PE  A 652 (-4.1A)
CA  A 622 (-3.3A)
1.21A 4fewB-3hdbA:
undetectable
4fewB-3hdbA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmq NH(3)-DEPENDENT
NAD(+) SYNTHETASE


(Salmonella
enterica)
PF02540
(NAD_synthase)
4 ASP A  52
ASP A 161
ASP A 235
GLU A 165
SO4  A 276 (-4.9A)
None
None
None
1.06A 4fewB-3hmqA:
undetectable
4fewB-3hmqA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwc CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 2


(Burkholderia
cepacia)
PF03241
(HpaB)
PF11794
(HpaB_N)
4 ASP A3461
ASP A3286
ASN A3358
ASP A3363
None
1.21A 4fewB-3hwcA:
undetectable
4fewB-3hwcA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks5 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE


(Agrobacterium
fabrum)
PF03009
(GDPD)
4 ASP A  36
ASP A  50
ASP A 231
ASP A  16
FE  A 250 (-2.6A)
EDO  A 256 (-3.0A)
None
EDO  A 256 (-3.5A)
1.11A 4fewB-3ks5A:
undetectable
4fewB-3ks5A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE


(Ruegeria
pomeroyi)
PF03009
(GDPD)
4 ASP A  51
ASP A 295
ASN A  32
GLU A 148
MG  A 313 (-2.6A)
None
None
MG  A 313 (-2.9A)
1.23A 4fewB-3l12A:
undetectable
4fewB-3l12A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no3 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE


(Parabacteroides
distasonis)
PF03009
(GDPD)
4 ASP A  61
ASP A 244
ASN A  42
GLU A 123
MG  A 301 (-2.5A)
None
None
MG  A 301 ( 2.8A)
1.21A 4fewB-3no3A:
undetectable
4fewB-3no3A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqx SECRETED
METALLOPROTEASE
MCP02


(Pseudoalteromonas
sp. SM9913)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
4 ASP A 411
ASN A 435
GLU A 377
GLU A 369
None
None
CA  A 511 (-2.7A)
ZN  A   1 (-2.3A)
1.21A 4fewB-3nqxA:
undetectable
4fewB-3nqxA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA


(Saccharomyces
cerevisiae)
PF00365
(PFK)
4 ASN B 524
GLU B 725
ASP B 355
GLU B 560
None
1.17A 4fewB-3o8oB:
undetectable
4fewB-3o8oB:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN


(Pyrococcus
abyssi)
PF00152
(tRNA-synt_2)
4 ASP A 195
ASP A  52
ASP A 118
GLU A 192
None
1.12A 4fewB-3p8tA:
undetectable
4fewB-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC


(Candida
albicans)
PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N)
4 ASN A 125
GLU A 355
ASP A 121
GLU A 343
None
1.21A 4fewB-3qo7A:
undetectable
4fewB-3qo7A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s83 GGDEF FAMILY PROTEIN

(Caulobacter
vibrioides)
PF00563
(EAL)
4 ASP A 469
ASP A 446
ASP A 339
GLU A 503
None
K  A 549 (-3.4A)
None
K  A 549 ( 4.7A)
1.15A 4fewB-3s83A:
undetectable
4fewB-3s83A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0p DNA POLYMERASE III,
BETA SUBUNIT


([Eubacterium]
rectale)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
4 ASP A 352
ASP A 311
ASN A 337
GLU A 335
None
0.78A 4fewB-3t0pA:
undetectable
4fewB-3t0pA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C)
4 ASP B 479
ASP B 190
ASN B 193
GLU B 192
None
1.21A 4fewB-3v0aB:
1.9
4fewB-3v0aB:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913)
PF00082
(Peptidase_S8)
4 ASP A 303
ASN A  16
GLU A  17
ASP A 231
None
1.15A 4fewB-3vv3A:
undetectable
4fewB-3vv3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvl HOMOSERINE
O-ACETYLTRANSFERASE


(Streptomyces
lavendulae)
PF00561
(Abhydrolase_1)
4 ASP A  65
GLU A  72
ASP A  56
GLU A  34
None
1.13A 4fewB-3vvlA:
undetectable
4fewB-3vvlA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE


(Escherichia
coli)
PF00348
(polyprenyl_synt)
4 ASP A  88
ASP A 211
ASP A 230
GLU A 233
IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
0.97A 4fewB-3wjoA:
undetectable
4fewB-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE


(Bifidobacterium
longum)
PF07944
(Glyco_hydro_127)
4 ASP A  77
ASN A 421
GLU A 338
GLU A 196
None
1.21A 4fewB-3wrfA:
undetectable
4fewB-3wrfA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE


(Vigna radiata)
PF03030
(H_PPase)
4 ASP A 257
ASP A 269
ASP A 287
ASN A 280
MG  A1767 (-2.5A)
MG  A1768 ( 3.9A)
2PN  A1773 (-3.9A)
MG  A1768 ( 4.9A)
1.13A 4fewB-4a01A:
0.7
4fewB-4a01A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE


(Vigna radiata)
PF03030
(H_PPase)
4 ASP A 691
ASP A 727
ASP A 269
ASP A 257
MG  A1771 ( 2.7A)
MG  A1769 ( 2.5A)
MG  A1768 ( 3.9A)
MG  A1767 (-2.5A)
0.89A 4fewB-4a01A:
0.7
4fewB-4a01A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bil DNA MATURASE B

(Escherichia
virus T7)
no annotation 4 ASP A 262
ASP A 250
GLU A 232
GLU A 254
None
1.12A 4fewB-4bilA:
undetectable
4fewB-4bilA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2o ALPHA-AMYLASE

(Geobacillus
thermoleovorans)
PF00128
(Alpha-amylase)
4 ASP A 463
ASN A 437
ASP A 458
GLU A 459
None
1.22A 4fewB-4e2oA:
undetectable
4fewB-4e2oA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 ASP A 150
ASP A 152
ASN A 289
ASP A 260
None
1.13A 4fewB-4f7kA:
undetectable
4fewB-4f7kA:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gkh AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB


(Acinetobacter
baumannii)
PF01636
(APH)
7 ASP A 165
ASP A 167
ASP A 198
ASN A 234
GLU A 238
ASP A 268
GLU A 269
KAN  A 301 (-3.7A)
KAN  A 301 (-3.3A)
KAN  A 301 (-3.0A)
KAN  A 301 (-3.9A)
None
KAN  A 301 (-3.8A)
KAN  A 301 (-3.2A)
0.62A 4fewB-4gkhA:
39.6
4fewB-4gkhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE


(Pyrobaculum
calidifontis)
PF00348
(polyprenyl_synt)
4 ASP A 226
GLU A 148
ASP A 244
GLU A 247
None
0.97A 4fewB-4gp1A:
undetectable
4fewB-4gp1A:
22.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII


(Streptomyces
rimosus)
PF01636
(APH)
4 ASP A 153
ASP A 184
ASP A 264
GLU A 265
None
0.45A 4fewB-4h05A:
29.7
4fewB-4h05A:
34.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens)
PF00149
(Metallophos)
PF02872
(5_nucleotid_C)
4 ASP A  47
ASN A 410
GLU A 409
ASP A 399
None
1.17A 4fewB-4h1sA:
undetectable
4fewB-4h1sA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hly K9

(Human
gammaherpesvirus
8)
PF00605
(IRF)
4 ASP A  98
GLU A  23
ASP A  49
GLU A  45
None
1.22A 4fewB-4hlyA:
undetectable
4fewB-4hlyA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE


(Paenibacillus
macerans)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
4 ASP A  59
ASP A  53
ASN A  32
ASP A 117
EDO  A 726 ( 4.9A)
CA  A 701 (-3.3A)
CA  A 701 (-3.2A)
GOL  A 717 (-2.9A)
1.22A 4fewB-4jclA:
undetectable
4fewB-4jclA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 ASP A 355
ASP A 164
GLU A 160
ASP A 361
None
1.16A 4fewB-4jlwA:
undetectable
4fewB-4jlwA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
4 ASP A3183
ASP A3225
ASN A3256
GLU A3143
None
1.19A 4fewB-4kc5A:
undetectable
4fewB-4kc5A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzj PUTATIVE
ALPHA-GALACTOSIDASE


(Bacteroides
fragilis)
PF05345
(He_PIG)
PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2)
4 ASP A 243
ASP A 165
ASP A 340
ASN A 128
GOL  A 600 (-3.6A)
GOL  A 600 (-3.2A)
None
None
1.17A 4fewB-4nzjA:
undetectable
4fewB-4nzjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlz SJCHGC07024 PROTEIN

(Schistosoma
japonicum)
PF00719
(Pyrophosphatase)
4 ASP A 118
GLU A  60
ASP A 113
GLU A 148
CO  A 401 (-2.5A)
None
CO  A 401 ( 2.8A)
None
1.21A 4fewB-4qlzA:
undetectable
4fewB-4qlzA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxv SEPTATION RING
FORMATION REGULATOR
EZRA


(Bacillus
subtilis)
PF06160
(EzrA)
4 ASP A  88
ASP A 109
ASN A 102
ASP A  30
None
0.87A 4fewB-4uxvA:
undetectable
4fewB-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE


(Pseudomonas
aeruginosa)
PF02540
(NAD_synthase)
4 ASP A  56
ASP A 168
ASP A 242
GLU A 172
None
1.05A 4fewB-4xfdA:
undetectable
4fewB-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgi GLUTAMATE
DEHYDROGENASE


(Burkholderia
thailandensis)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 ASP A  96
ASP A  22
GLU A  74
GLU A 101
None
1.16A 4fewB-4xgiA:
undetectable
4fewB-4xgiA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1u METALLO-BETA-LACTAMA
SE


(Serratia
marcescens)
PF00753
(Lactamase_B)
4 ASP A  76
ASP A 174
GLU A 217
ASP A  41
ZN  A 302 ( 2.5A)
None
HIW  A 321 ( 4.6A)
None
1.14A 4fewB-5b1uA:
undetectable
4fewB-5b1uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzv PROTEIN PCDHA7

(Mus musculus)
PF00028
(Cadherin)
PF08266
(Cadherin_2)
4 ASP A 454
ASP A 333
ASN A 420
GLU A 457
CA  A 612 (-3.0A)
None
CA  A 612 (-3.5A)
None
1.13A 4fewB-5dzvA:
undetectable
4fewB-5dzvA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzv PROTEIN PCDHA7

(Mus musculus)
PF00028
(Cadherin)
PF08266
(Cadherin_2)
4 ASP A 454
ASP A 333
GLU A 457
GLU A 387
CA  A 612 (-3.0A)
None
None
CA  A 611 ( 2.8A)
1.17A 4fewB-5dzvA:
undetectable
4fewB-5dzvA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbb NUCLEASE S1

(Aspergillus
oryzae)
PF02265
(S1-P1_nuclease)
4 ASP A 139
ASN A  23
GLU A 177
ASP A  65
ZN  A 402 (-2.5A)
BTB  A1002 (-3.8A)
BTB  A1002 (-2.8A)
PO4  A 601 ( 2.7A)
1.11A 4fewB-5fbbA:
undetectable
4fewB-5fbbA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqe BETA-N-ACETYLGALACTO
SAMINIDASE


(Clostridium
perfringens)
PF13320
(DUF4091)
4 ASP A 404
ASN A 452
GLU A 415
GLU A 531
None
1.17A 4fewB-5fqeA:
undetectable
4fewB-5fqeA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE


(Staphylococcus
aureus)
PF00348
(polyprenyl_synt)
4 ASP A  86
ASP A 210
GLU A 144
ASP A 228
None
1.15A 4fewB-5h9dA:
undetectable
4fewB-5h9dA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic5 CANDIDATE RESPONSE
REGULATOR, CHEY


(Ramlibacter
tataouinensis)
PF00072
(Response_reg)
4 ASP A  64
GLU A  99
ASP A  11
GLU A   9
MG  A 204 (-2.8A)
None
None
MG  A 204 ( 4.2A)
1.09A 4fewB-5ic5A:
undetectable
4fewB-5ic5A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iqk BETA-LACTAMASE RM3

(uncultured
bacterium)
PF00753
(Lactamase_B)
4 ASP A 112
ASP A 210
GLU A 256
ASP A  77
ZN  A 402 (-2.4A)
None
None
None
1.07A 4fewB-5iqkA:
undetectable
4fewB-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iry DESMOCOLLIN-1

(Homo sapiens)
PF00028
(Cadherin)
4 ASP A 348
ASP A 516
ASP A 465
GLU A 402
CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
0.97A 4fewB-5iryA:
undetectable
4fewB-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2


(Homo sapiens)
PF01094
(ANF_receptor)
PF07562
(NCD3G)
4 ASP A 188
GLU A 375
ASP A 295
GLU A 318
None
1.22A 4fewB-5kznA:
undetectable
4fewB-5kznA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1


(Saccharomyces
cerevisiae)
no annotation 4 ASP W 464
ASP W 317
ASP W 498
ASN W 459
None
1.16A 4fewB-5o9gW:
undetectable
4fewB-5o9gW:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucm PROLINE--TRNA LIGASE

(Pseudomonas
aeruginosa)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit)
4 ASP A 356
ASN A 372
ASP A 251
GLU A 250
None
1.14A 4fewB-5ucmA:
3.6
4fewB-5ucmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vis DIHYDROPTEROATE
SYNTHASE


(soil metagenome)
PF00809
(Pterin_bind)
4 ASP A 106
ASP A  86
ASP A 136
GLU A  63
None
1.12A 4fewB-5visA:
undetectable
4fewB-5visA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzr ALPHA-N-ACETYLGALACT
OSAMINIDASE


(Bifidobacterium
bifidum)
PF11308
(Glyco_hydro_129)
4 ASP A 561
ASP A 322
ASP A 371
ASP A 330
DJN  A 702 (-2.9A)
CA  A 703 (-2.1A)
DJN  A 702 (-3.1A)
DJN  A 702 (-2.6A)
1.17A 4fewB-5wzrA:
undetectable
4fewB-5wzrA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR


(Homo sapiens)
no annotation 4 ASP A2330
ASP A2335
ASP A2475
ASP A2494
None
1.21A 4fewB-5yz0A:
3.6
4fewB-5yz0A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER


(Homo sapiens)
no annotation 4 ASP A1810
ASN A1742
ASP A1709
GLU A1705
None
0.96A 4fewB-5zalA:
undetectable
4fewB-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE


(Enterococcus
faecalis)
no annotation 4 ASP A  53
ASP A 162
ASP A 236
GLU A 166
None
1.13A 4fewB-6c8qA:
undetectable
4fewB-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus)
no annotation 4 ASP A 396
ASP A 393
ASP A 213
GLU A 240
MG  A 702 ( 4.8A)
MG  A 702 (-1.7A)
None
GNP  A 500 ( 4.4A)
1.19A 4fewB-6ceyA:
17.8
4fewB-6ceyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhv GLUCOAMYLASE

(Penicillium
oxalicum)
no annotation 4 ASP A 345
ASP A 210
GLU A 436
ASP A 281
None
None
B3P  A 652 ( 4.6A)
None
0.97A 4fewB-6fhvA:
undetectable
4fewB-6fhvA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae)
no annotation 4 ASP A 339
ASP A 205
GLU A 432
ASP A 275
None
None
ACR  A 801 (-4.4A)
None
1.06A 4fewB-6fhwA:
undetectable
4fewB-6fhwA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger)
no annotation 4 ASP A 333
ASP A 200
GLU A 424
ASP A 269
None
1.05A 4fewB-6frvA:
undetectable
4fewB-6frvA:
17.58