SIMILAR PATTERNS OF AMINO ACIDS FOR 4FEV_B_KANB301_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cvm | PHYTASE (Bacillusamyloliquefaciens) |
PF02333(Phytase) | 4 | ASP A 52ASN A 99GLU A 157ASP A 314 | CD A 814 (-3.9A) CD A 813 ( 4.1A)None CD A 814 (-2.6A) | 1.17A | 4fevB-1cvmA:0.0 | 4fevB-1cvmA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gt9 | KUMAMOLYSIN (Bacillussubtilis) |
PF00082(Peptidase_S8) | 5 | ASP 1 268ASN 1 66GLU 1 32ASP 1 38GLU 1 39 | None | 1.42A | 4fevB-1gt91:undetectable | 4fevB-1gt91:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h3g | CYCLOMALTODEXTRINASE (Flavobacteriumsp. 92) |
PF00128(Alpha-amylase)PF09087(Cyc-maltodext_N)PF10438(Cyc-maltodext_C) | 4 | ASP A 152ASP A 146ASN A 124ASP A 200 | None CA A 700 (-3.2A) CA A 700 (-3.0A)None | 1.23A | 4fevB-1h3gA:1.8 | 4fevB-1h3gA:19.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1idm | 3-ISOPROPYLMALATEDEHYDROGENASE (Thermusthermophilus) |
PF00180(Iso_dh) | 4 | ASP A 243ASN A 100GLU A 268ASP A 239 | None | 1.20A | 4fevB-1idmA:undetectable | 4fevB-1idmA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iv8 | MALTOOLIGOSYLTREHALOSE SYNTHASE (Sulfolobusacidocaldarius) |
PF00128(Alpha-amylase)PF09196(DUF1953) | 4 | ASP A 228ASP A 596ASP A 443GLU A 255 | NoneMLZ A 513 ( 4.9A)NoneNone | 1.17A | 4fevB-1iv8A:0.0 | 4fevB-1iv8A:16.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j5s | URONATE ISOMERASE (Thermotogamaritima) |
PF02614(UxaC) | 4 | ASP A 370ASP A 55ASN A 95GLU A 99 | None | 1.04A | 4fevB-1j5sA:0.0 | 4fevB-1j5sA:20.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1l8t | AMINOGLYCOSIDE3'-PHOSPHOTRANSFERASE (Enterococcusfaecalis) |
PF01636(APH) | 4 | ASP A 190GLU A 230ASP A 261GLU A 262 | KAN A 1 (-3.2A)KAN A 1 (-2.8A)KAN A 1 (-3.8A)KAN A 1 (-3.1A) | 0.64A | 4fevB-1l8tA:26.9 | 4fevB-1l8tA:31.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nd4 | AMINOGLYCOSIDE3'-PHOSPHOTRANSFERASE (Klebsiellapneumoniae) |
PF01636(APH) | 6 | ASP A 157ASP A 159ASP A 190GLU A 230ASP A 261GLU A 262 | KAN A1300 (-3.7A)KAN A1300 (-3.2A)KAN A1300 ( 2.8A)KAN A1300 (-4.1A)KAN A1300 (-3.8A)KAN A1300 (-3.1A) | 0.76A | 4fevB-1nd4A:30.5 | 4fevB-1nd4A:33.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nnh | ASPARAGINYL-TRNASYNTHETASE-RELATEDPEPTIDE (Pyrococcusfuriosus) |
PF00152(tRNA-synt_2) | 4 | ASP A 195ASP A 52ASP A 118GLU A 192 | None | 1.13A | 4fevB-1nnhA:0.0 | 4fevB-1nnhA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pu7 | 3-METHYLADENINE DNAGLYCOSYLASE (Helicobacterpylori) |
PF00633(HHH)PF00730(HhH-GPD) | 4 | ASP A 135ASP A 166GLU A 121GLU A 175 | None | 1.16A | 4fevB-1pu7A:undetectable | 4fevB-1pu7A:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r6b | CLPA PROTEIN (Escherichiacoli) |
PF00004(AAA)PF02861(Clp_N)PF07724(AAA_2)PF10431(ClpB_D2-small) | 4 | ASP X 285ASP X 396GLU X 225GLU X 286 | MG X 782 (-3.7A)ADP X 780 (-4.1A)None MG X 782 ( 4.4A) | 0.91A | 4fevB-1r6bX:undetectable | 4fevB-1r6bX:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t1e | KUMAMOLISIN (Bacillus sp.MN-32) |
PF00082(Peptidase_S8)PF09286(Pro-kuma_activ) | 5 | ASP A 457ASN A 255GLU A 221ASP A 227GLU A 228 | None | 1.32A | 4fevB-1t1eA:undetectable | 4fevB-1t1eA:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tlq | HYPOTHETICAL PROTEINYPJQ (Bacillussubtilis) |
PF04608(PgpA) | 4 | ASP A 99ASP A 133GLU A 93ASP A 144 | CA A 190 (-2.3A)NoneNoneNone | 1.19A | 4fevB-1tlqA:undetectable | 4fevB-1tlqA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ux6 | THROMBOSPONDIN-1 (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C) | 4 | ASP A 933ASP A 868ASN A 855ASP A 874 | None CA A2007 ( 2.7A)NoneNone | 1.18A | 4fevB-1ux6A:undetectable | 4fevB-1ux6A:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wxf | NH(3)-DEPENDENTNAD(+) SYNTHETASE (Escherichiacoli) |
PF02540(NAD_synthase) | 4 | ASP A 52ASP A 161ASP A 235GLU A 165 | None | 1.12A | 4fevB-1wxfA:undetectable | 4fevB-1wxfA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dbn | HYPOTHETICAL PROTEINYBIU (Escherichiacoli) |
PF07350(DUF1479) | 4 | ASP A 116ASN A 113GLU A 397ASP A 111 | None | 1.11A | 4fevB-2dbnA:undetectable | 4fevB-2dbnA:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dht | 409AA LONGHYPOTHETICALNADP-DEPENDENTISOCITRATEDEHYDROGENASE (Sulfurisphaeratokodaii) |
PF00180(Iso_dh) | 4 | ASP A 302ASN A 123GLU A 327ASP A 298 | None | 1.22A | 4fevB-2dhtA:undetectable | 4fevB-2dhtA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eb1 | ENDORIBONUCLEASEDICER (Homo sapiens) |
PF00636(Ribonuclease_3) | 4 | ASP A 152ASN A 84ASP A 51GLU A 47 | MG A 502 (-3.1A)None MG A 505 (-2.8A) MG A 502 (-3.1A) | 1.12A | 4fevB-2eb1A:undetectable | 4fevB-2eb1A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f6d | GLUCOAMYLASE GLU1 (Saccharomycopsisfibuligera) |
PF00723(Glyco_hydro_15) | 4 | ASP A 349ASP A 207GLU A 456ASP A 288 | NoneNoneACR A 995 ( 4.6A)None | 1.04A | 4fevB-2f6dA:undetectable | 4fevB-2f6dA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i2x | METHYLTRANSFERASE 1 (Methanosarcinabarkeri) |
PF12176(MtaB) | 4 | ASN A 224GLU A 313ASP A 219GLU A 272 | None K A 511 (-3.6A)NoneNone | 1.16A | 4fevB-2i2xA:undetectable | 4fevB-2i2xA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k0z | UNCHARACTERIZEDPROTEIN HP1203 (Helicobacterpylori) |
PF00581(Rhodanese) | 4 | ASP A 43ASN A 42GLU A 24GLU A 45 | None | 0.92A | 4fevB-2k0zA:undetectable | 4fevB-2k0zA:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nli | LACTATE OXIDASE (Aerococcusviridans) |
PF01070(FMN_dh) | 4 | ASP A 24ASP A 55ASN A 21GLU A 27 | None | 1.19A | 4fevB-2nliA:undetectable | 4fevB-2nliA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o3b | NUCLEASESUGAR-NON-SPECIFICNUCLEASE INHIBITOR (Nostoc sp. PCC7120) |
PF01223(Endonuclease_NS)PF07924(NuiA) | 4 | ASP A 153ASN A 157GLU B 111GLU A 233 | None | 1.11A | 4fevB-2o3bA:undetectable | 4fevB-2o3bA:23.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2otd | GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE (Shigellaflexneri) |
PF03009(GDPD) | 4 | ASP A 41ASP A 235ASN A 22GLU A 114 | PO4 A 301 (-3.8A)NoneNonePO4 A 301 (-3.4A) | 1.20A | 4fevB-2otdA:undetectable | 4fevB-2otdA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pz8 | NH(3)-DEPENDENTNAD(+) SYNTHETASE (Bacillusanthracis) |
PF02540(NAD_synthase) | 4 | ASP A 51ASP A 159ASP A 233GLU A 163 | APC A3001 (-3.7A)NoneNoneAPC A3001 ( 4.6A) | 1.11A | 4fevB-2pz8A:undetectable | 4fevB-2pz8A:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rhp | THROMBOSPONDIN-2 (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C)PF07645(EGF_CA)PF12947(EGF_3) | 4 | ASP A 894ASP A 890ASP A 910ASN A 902 | None CA A 7 ( 2.5A) CA A1175 ( 2.5A) CA A1176 (-3.1A) | 1.21A | 4fevB-2rhpA:undetectable | 4fevB-2rhpA:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vn7 | GLUCOAMYLASE (Trichodermareesei) |
PF00686(CBM_20)PF00723(Glyco_hydro_15) | 4 | ASP A 313ASP A 176GLU A 404ASP A 249 | NoneNoneBTB A 620 (-4.0A)None | 0.92A | 4fevB-2vn7A:undetectable | 4fevB-2vn7A:16.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wba | TRYPANOTHIONEREDUCTASE (Trypanosomabrucei) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | ASP A 432ASP A 71ASN A 245GLU A 75 | None | 1.03A | 4fevB-2wbaA:undetectable | 4fevB-2wbaA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xhe | UNC18 (Monosigabrevicollis) |
PF00995(Sec1) | 4 | ASP A 56ASP A 30ASP A 86ASN A 79 | None | 0.98A | 4fevB-2xheA:undetectable | 4fevB-2xheA:16.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yeq | ALKALINE PHOSPHATASED (Bacillussubtilis) |
PF09423(PhoD)PF16655(PhoD_N) | 4 | ASP A 289ASP A 380GLU A 504GLU A 223 | None CA A1525 ( 3.4A)EDO A 540 (-3.7A)None | 1.17A | 4fevB-2yeqA:undetectable | 4fevB-2yeqA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z5l | TYLACTONE SYNTHASESTARTER MODULE ANDMODULES 1 & 2 (Streptomycesfradiae) |
PF08659(KR) | 4 | ASP A 326ASN A 377GLU A 154GLU A 423 | None | 1.10A | 4fevB-2z5lA:undetectable | 4fevB-2z5lA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zuy | YESX PROTEIN (Bacillussubtilis) |
PF01839(FG-GAP) | 4 | ASP A 125ASP A 191GLU A 241ASP A 189 | CA A 623 (-3.2A) CA A 624 (-2.9A)None CA A 624 (-3.2A) | 1.13A | 4fevB-2zuyA:undetectable | 4fevB-2zuyA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a5v | ALPHA-GALACTOSIDASE (Umbelopsisvinacea) |
PF16499(Melibiase_2) | 4 | ASP A 129ASP A 51ASP A 238ASN A 14 | TRS A 841 (-4.0A)TRS A 841 (-3.3A)NoneNone | 1.22A | 4fevB-3a5vA:undetectable | 4fevB-3a5vA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cc1 | PUTATIVEALPHA-N-ACETYLGALACTOSAMINIDASE (Bacillushalodurans) |
PF16499(Melibiase_2) | 4 | ASP A 285ASP A 19ASP A 183ASP A 52 | NoneNoneIMD A 437 ( 3.8A)IMD A 437 (-3.3A) | 1.20A | 4fevB-3cc1A:undetectable | 4fevB-3cc1A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egw | RESPIRATORY NITRATEREDUCTASE 1 ALPHACHAINRESPIRATORY NITRATEREDUCTASE 1 BETACHAIN (Escherichiacoli) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF13247(Fer4_11)PF14710(Nitr_red_alph_N)PF14711(Nitr_red_bet_C) | 4 | ASP A 33ASP B 482ASP B 500GLU B 472 | None | 1.12A | 4fevB-3egwA:undetectable | 4fevB-3egwA:12.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eqa | GLUCOAMYLASE (Aspergillusniger) |
PF00723(Glyco_hydro_15) | 4 | ASP A 333ASP A 200GLU A 424ASP A 269 | None | 0.97A | 4fevB-3eqaA:undetectable | 4fevB-3eqaA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g1n | E3 UBIQUITIN-PROTEINLIGASE HUWE1 (Homo sapiens) |
PF00632(HECT) | 4 | ASP A4087GLU A4248ASP A4145GLU A4149 | NA A5001 (-3.4A)NoneNoneNone | 1.13A | 4fevB-3g1nA:undetectable | 4fevB-3g1nA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h4x | PHOSPHATIDYLINOSITOL-SPECIFICPHOSPHOLIPASE C1 (Streptomycesantibioticus) |
PF16670(PI-PLC-C1) | 4 | ASP A 62ASP A 287ASN A 38GLU A 129 | NoneEOH A 348 ( 4.5A)NoneNone | 0.89A | 4fevB-3h4xA:undetectable | 4fevB-3h4xA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h4x | PHOSPHATIDYLINOSITOL-SPECIFICPHOSPHOLIPASE C1 (Streptomycesantibioticus) |
PF16670(PI-PLC-C1) | 4 | ASP A 62ASP A 287GLU A 41GLU A 129 | NoneEOH A 348 ( 4.5A)NoneNone | 1.04A | 4fevB-3h4xA:undetectable | 4fevB-3h4xA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h7n | NUCLEOPORIN NUP120 (Saccharomycescerevisiae) |
PF11715(Nup160) | 4 | ASP A 8ASN A 383ASP A 388GLU A 392 | None | 1.06A | 4fevB-3h7nA:undetectable | 4fevB-3h7nA:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hdb | AAHIV (Deinagkistrodonacutus) |
PF00200(Disintegrin)PF01421(Reprolysin)PF08516(ADAM_CR) | 4 | ASP A 416ASN A 229GLU A 233GLU A 410 | CA A 622 (-3.3A)2PE A 652 (-3.5A)2PE A 652 (-4.1A) CA A 622 (-3.3A) | 1.20A | 4fevB-3hdbA:undetectable | 4fevB-3hdbA:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hmq | NH(3)-DEPENDENTNAD(+) SYNTHETASE (Salmonellaenterica) |
PF02540(NAD_synthase) | 4 | ASP A 52ASP A 161ASP A 235GLU A 165 | SO4 A 276 (-4.9A)NoneNoneNone | 1.07A | 4fevB-3hmqA:undetectable | 4fevB-3hmqA:25.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hwc | CHLOROPHENOL-4-MONOOXYGENASE COMPONENT 2 (Burkholderiacepacia) |
PF03241(HpaB)PF11794(HpaB_N) | 4 | ASP A3461ASP A3286ASN A3358ASP A3363 | None | 1.20A | 4fevB-3hwcA:undetectable | 4fevB-3hwcA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ic9 | DIHYDROLIPOAMIDEDEHYDROGENASE (Colwelliapsychrerythraea) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | ASP A 324ASN A 312GLU A 295ASP A 310 | NA A 491 (-3.0A) NA A 491 (-2.6A)NoneFAD A 490 (-3.0A) | 1.00A | 4fevB-3ic9A:undetectable | 4fevB-3ic9A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ks5 | GLYCEROPHOSPHORYLDIESTERPHOSPHODIESTERASE (Agrobacteriumfabrum) |
PF03009(GDPD) | 4 | ASP A 36ASP A 50ASP A 231ASP A 16 | FE A 250 (-2.6A)EDO A 256 (-3.0A)NoneEDO A 256 (-3.5A) | 1.13A | 4fevB-3ks5A:undetectable | 4fevB-3ks5A:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3no3 | GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE (Parabacteroidesdistasonis) |
PF03009(GDPD) | 4 | ASP A 61ASP A 244ASN A 42GLU A 123 | MG A 301 (-2.5A)NoneNone MG A 301 ( 2.8A) | 1.20A | 4fevB-3no3A:undetectable | 4fevB-3no3A:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nqx | SECRETEDMETALLOPROTEASEMCP02 (Pseudoalteromonassp. SM9913) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 4 | ASP A 411ASN A 435GLU A 377GLU A 369 | NoneNone CA A 511 (-2.7A) ZN A 1 (-2.3A) | 1.20A | 4fevB-3nqxA:undetectable | 4fevB-3nqxA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p8t | ASNS-LIKEASPARAGINYL-TRNASYNTHETASE RELATEDPROTEIN (Pyrococcusabyssi) |
PF00152(tRNA-synt_2) | 4 | ASP A 195ASP A 52ASP A 118GLU A 192 | None | 1.12A | 4fevB-3p8tA:0.5 | 4fevB-3p8tA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pao | ADENOSINE DEAMINASE (Pseudomonasaeruginosa) |
PF00962(A_deaminase) | 4 | ASP A 277ASP A 219ASP A 100GLU A 171 | ZN A 327 ( 2.6A)NoneNoneNone | 1.22A | 4fevB-3paoA:undetectable | 4fevB-3paoA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rys | ADENOSINE DEAMINASE1 (Paenarthrobacteraurescens) |
PF00962(A_deaminase) | 4 | ASP A 280ASP A 222ASP A 103GLU A 174 | ZN A 344 ( 2.5A)NoneNoneNone | 1.21A | 4fevB-3rysA:undetectable | 4fevB-3rysA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s83 | GGDEF FAMILY PROTEIN (Caulobactervibrioides) |
PF00563(EAL) | 4 | ASP A 469ASP A 446ASP A 339GLU A 503 | None K A 549 (-3.4A)None K A 549 ( 4.7A) | 1.11A | 4fevB-3s83A:undetectable | 4fevB-3s83A:24.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t0p | DNA POLYMERASE III,BETA SUBUNIT ([Eubacterium]rectale) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 4 | ASP A 352ASP A 311ASN A 337GLU A 335 | None | 0.78A | 4fevB-3t0pA:undetectable | 4fevB-3t0pA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v0a | NTNH (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07953(Toxin_R_bind_N)PF08470(NTNH_C) | 4 | ASP B 479ASP B 190ASN B 193GLU B 192 | None | 1.18A | 4fevB-3v0aB:undetectable | 4fevB-3v0aB:11.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vuo | NTNHA (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07953(Toxin_R_bind_N)PF08470(NTNH_C) | 4 | ASP A 479ASP A 190ASN A 193GLU A 192 | None | 1.18A | 4fevB-3vuoA:undetectable | 4fevB-3vuoA:12.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vv3 | DESEASIN MCP-01 (Pseudoalteromonassp. SM9913) |
PF00082(Peptidase_S8) | 4 | ASP A 303ASN A 16GLU A 17ASP A 231 | None | 1.16A | 4fevB-3vv3A:undetectable | 4fevB-3vv3A:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vvl | HOMOSERINEO-ACETYLTRANSFERASE (Streptomyceslavendulae) |
PF00561(Abhydrolase_1) | 4 | ASP A 65GLU A 72ASP A 56GLU A 34 | None | 1.16A | 4fevB-3vvlA:undetectable | 4fevB-3vvlA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wjo | OCTAPRENYLDIPHOSPHATE SYNTHASE (Escherichiacoli) |
PF00348(polyprenyl_synt) | 4 | ASP A 88ASP A 211ASP A 230GLU A 233 | IPE A 401 (-3.3A)IPE A 402 ( 4.6A)NoneNone | 0.93A | 4fevB-3wjoA:undetectable | 4fevB-3wjoA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wrf | NON-REDUCING ENDBETA-L-ARABINOFURANOSIDASE (Bifidobacteriumlongum) |
PF07944(Glyco_hydro_127) | 4 | ASP A 77ASN A 421GLU A 338GLU A 196 | None | 1.23A | 4fevB-3wrfA:undetectable | 4fevB-3wrfA:17.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a01 | PROTONPYROPHOSPHATASE (Vigna radiata) |
PF03030(H_PPase) | 4 | ASP A 257ASP A 269ASP A 287ASN A 280 | MG A1767 (-2.5A) MG A1768 ( 3.9A)2PN A1773 (-3.9A) MG A1768 ( 4.9A) | 1.16A | 4fevB-4a01A:undetectable | 4fevB-4a01A:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a01 | PROTONPYROPHOSPHATASE (Vigna radiata) |
PF03030(H_PPase) | 4 | ASP A 691ASP A 727ASP A 269ASP A 257 | MG A1771 ( 2.7A) MG A1769 ( 2.5A) MG A1768 ( 3.9A) MG A1767 (-2.5A) | 0.86A | 4fevB-4a01A:undetectable | 4fevB-4a01A:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bxs | VENOM PROTHROMBINACTIVATORPSEUTARIN-CNON-CATALYTICSUBUNIT (Pseudonajatextilis) |
PF00754(F5_F8_type_C)PF07732(Cu-oxidase_3) | 4 | ASP V 487ASN V 410GLU V 449GLU V 331 | None | 1.02A | 4fevB-4bxsV:undetectable | 4fevB-4bxsV:11.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cot | EXTRACELLULARENDO-ALPHA-(1->5)-L-ARABINANASE 2 (Bacillussubtilis) |
PF04616(Glyco_hydro_43)PF16369(GH43_C) | 4 | ASP A 287ASP A 396ASN A 253ASP A 392 | None | 1.16A | 4fevB-4cotA:undetectable | 4fevB-4cotA:18.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dhg | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Thermobisporabispora) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ASP A 343ASP A 243GLU A 239ASP A 217 | None | 1.17A | 4fevB-4dhgA:undetectable | 4fevB-4dhgA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f7k | LACCASE (unculturedbacterium) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | ASP A 150ASP A 152ASN A 289ASP A 260 | None | 1.11A | 4fevB-4f7kA:undetectable | 4fevB-4f7kA:21.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4gkh | AMINOGLYCOSIDE3'-PHOSPHOTRANSFERASE APHA1-IAB (Acinetobacterbaumannii) |
PF01636(APH) | 7 | ASP A 165ASP A 167ASP A 198ASN A 234GLU A 238ASP A 268GLU A 269 | KAN A 301 (-3.7A)KAN A 301 (-3.3A)KAN A 301 (-3.0A)KAN A 301 (-3.9A)NoneKAN A 301 (-3.8A)KAN A 301 (-3.2A) | 0.54A | 4fevB-4gkhA:38.7 | 4fevB-4gkhA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4gkh | AMINOGLYCOSIDE3'-PHOSPHOTRANSFERASE APHA1-IAB (Acinetobacterbaumannii) |
PF01636(APH) | 4 | ASP A 165ASP A 167ASP A 202ASN A 234 | KAN A 301 (-3.7A)KAN A 301 (-3.3A)ACT A 305 (-4.6A)KAN A 301 (-3.9A) | 1.23A | 4fevB-4gkhA:38.7 | 4fevB-4gkhA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gp1 | POLYPRENYLSYNTHETASE (Pyrobaculumcalidifontis) |
PF00348(polyprenyl_synt) | 4 | ASP A 226GLU A 148ASP A 244GLU A 247 | None | 1.04A | 4fevB-4gp1A:undetectable | 4fevB-4gp1A:22.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4h05 | AMINOGLYCOSIDE-O-PHOSPHOTRANSFERASE VIII (Streptomycesrimosus) |
PF01636(APH) | 4 | ASP A 153ASP A 184ASP A 264GLU A 265 | None | 0.47A | 4fevB-4h05A:28.9 | 4fevB-4h05A:34.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h1s | 5'-NUCLEOTIDASE (Homo sapiens) |
PF00149(Metallophos)PF02872(5_nucleotid_C) | 4 | ASP A 47ASN A 410GLU A 409ASP A 399 | None | 1.19A | 4fevB-4h1sA:undetectable | 4fevB-4h1sA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hly | K9 (Humangammaherpesvirus8) |
PF00605(IRF) | 4 | ASP A 98GLU A 23ASP A 49GLU A 45 | None | 1.20A | 4fevB-4hlyA:undetectable | 4fevB-4hlyA:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jcl | CYCLOMALTODEXTRINGLUCANOTRANSFERASE (Paenibacillusmacerans) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG) | 4 | ASP A 59ASP A 53ASN A 32ASP A 117 | EDO A 726 ( 4.9A) CA A 701 (-3.3A) CA A 701 (-3.2A)GOL A 717 (-2.9A) | 1.20A | 4fevB-4jclA:undetectable | 4fevB-4jclA:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jlw | GLUTATHIONE-INDEPENDENT FORMALDEHYDEDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | ASP A 355ASP A 164GLU A 160ASP A 361 | None | 1.11A | 4fevB-4jlwA:undetectable | 4fevB-4jlwA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jxy | TRANS-HEXAPRENYLTRANSTRANSFERASE (Pseudoalteromonasatlantica) |
PF00348(polyprenyl_synt) | 4 | ASP A 212GLU A 146ASP A 230GLU A 233 | None | 1.06A | 4fevB-4jxyA:undetectable | 4fevB-4jxyA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kc5 | RHIE PROTEIN (Paraburkholderiarhizoxinica) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 4 | ASP A3183ASP A3225ASN A3256GLU A3143 | None | 1.15A | 4fevB-4kc5A:undetectable | 4fevB-4kc5A:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nzj | PUTATIVEALPHA-GALACTOSIDASE (Bacteroidesfragilis) |
PF05345(He_PIG)PF10632(He_PIG_assoc)PF16499(Melibiase_2) | 4 | ASP A 243ASP A 165ASP A 340ASN A 128 | GOL A 600 (-3.6A)GOL A 600 (-3.2A)NoneNone | 1.16A | 4fevB-4nzjA:undetectable | 4fevB-4nzjA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qlz | SJCHGC07024 PROTEIN (Schistosomajaponicum) |
PF00719(Pyrophosphatase) | 4 | ASP A 118ASN A 114GLU A 60GLU A 148 | CO A 401 (-2.5A)NoneNoneNone | 1.22A | 4fevB-4qlzA:undetectable | 4fevB-4qlzA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qlz | SJCHGC07024 PROTEIN (Schistosomajaponicum) |
PF00719(Pyrophosphatase) | 4 | ASP A 118GLU A 60ASP A 113GLU A 148 | CO A 401 (-2.5A)None CO A 401 ( 2.8A)None | 1.18A | 4fevB-4qlzA:undetectable | 4fevB-4qlzA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uxv | SEPTATION RINGFORMATION REGULATOREZRA (Bacillussubtilis) |
PF06160(EzrA) | 4 | ASP A 88ASP A 109ASN A 102ASP A 30 | None | 0.89A | 4fevB-4uxvA:undetectable | 4fevB-4uxvA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xfd | NH(3)-DEPENDENTNAD(+) SYNTHETASE (Pseudomonasaeruginosa) |
PF02540(NAD_synthase) | 4 | ASP A 56ASP A 168ASP A 242GLU A 172 | None | 1.06A | 4fevB-4xfdA:undetectable | 4fevB-4xfdA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xhz | PROTOCADHERIN-15 (Homo sapiens) |
PF00028(Cadherin) | 4 | ASP A 897ASP A 931GLU A 992GLU A 862 | CA A2002 (-3.0A) CA A2001 (-2.2A)None CA A2002 ( 2.4A) | 1.16A | 4fevB-4xhzA:undetectable | 4fevB-4xhzA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zps | MCG133388, ISOFORMCRA_M (Mus musculus) |
PF00028(Cadherin)PF08266(Cadherin_2) | 4 | ASP A 208GLU A 176ASP A 205GLU A 242 | CA A 806 ( 2.8A)None CA A 804 (-2.7A)None | 1.20A | 4fevB-4zpsA:undetectable | 4fevB-4zpsA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b1u | METALLO-BETA-LACTAMASE (Serratiamarcescens) |
PF00753(Lactamase_B) | 4 | ASP A 76ASP A 174GLU A 217ASP A 41 | ZN A 302 ( 2.5A)NoneHIW A 321 ( 4.6A)None | 1.17A | 4fevB-5b1uA:undetectable | 4fevB-5b1uA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dzv | PROTEIN PCDHA7 (Mus musculus) |
PF00028(Cadherin)PF08266(Cadherin_2) | 4 | ASP A 454ASP A 333ASN A 420GLU A 457 | CA A 612 (-3.0A)None CA A 612 (-3.5A)None | 1.16A | 4fevB-5dzvA:undetectable | 4fevB-5dzvA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dzv | PROTEIN PCDHA7 (Mus musculus) |
PF00028(Cadherin)PF08266(Cadherin_2) | 4 | ASP A 454ASP A 333GLU A 457GLU A 387 | CA A 612 (-3.0A)NoneNone CA A 611 ( 2.8A) | 1.20A | 4fevB-5dzvA:undetectable | 4fevB-5dzvA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fbb | NUCLEASE S1 (Aspergillusoryzae) |
PF02265(S1-P1_nuclease) | 4 | ASP A 139ASN A 23GLU A 177ASP A 65 | ZN A 402 (-2.5A)BTB A1002 (-3.8A)BTB A1002 (-2.8A)PO4 A 601 ( 2.7A) | 1.09A | 4fevB-5fbbA:undetectable | 4fevB-5fbbA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fqe | BETA-N-ACETYLGALACTOSAMINIDASE (Clostridiumperfringens) |
PF13320(DUF4091) | 4 | ASP A 404ASN A 452GLU A 415GLU A 531 | None | 1.21A | 4fevB-5fqeA:undetectable | 4fevB-5fqeA:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h9d | FARNESYLPYROPHOSPHATESYNTHETASE (Staphylococcusaureus) |
PF00348(polyprenyl_synt) | 4 | ASP A 86ASP A 210GLU A 144ASP A 228 | None | 1.13A | 4fevB-5h9dA:undetectable | 4fevB-5h9dA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ic5 | CANDIDATE RESPONSEREGULATOR, CHEY (Ramlibactertataouinensis) |
PF00072(Response_reg) | 4 | ASP A 64GLU A 99ASP A 11GLU A 9 | MG A 204 (-2.8A)NoneNone MG A 204 ( 4.2A) | 1.16A | 4fevB-5ic5A:undetectable | 4fevB-5ic5A:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iqk | BETA-LACTAMASE RM3 (unculturedbacterium) |
PF00753(Lactamase_B) | 4 | ASP A 112ASP A 210GLU A 256ASP A 77 | ZN A 402 (-2.4A)NoneNoneNone | 1.11A | 4fevB-5iqkA:undetectable | 4fevB-5iqkA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iry | DESMOCOLLIN-1 (Homo sapiens) |
PF00028(Cadherin) | 4 | ASP A 348ASP A 516ASP A 465GLU A 402 | CA A 609 ( 3.1A) CA A 611 (-3.0A) CA A 610 ( 3.8A) CA A 609 ( 2.1A) | 0.97A | 4fevB-5iryA:undetectable | 4fevB-5iryA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ldt | MOMP PORIN (Campylobacterjejuni) |
PF05538(Campylo_MOMP) | 4 | ASP A 21ASP A 155ASN A 36GLU A 300 | None CA A 501 (-3.3A)NoneNone | 1.07A | 4fevB-5ldtA:undetectable | 4fevB-5ldtA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ucm | PROLINE--TRNA LIGASE (Pseudomonasaeruginosa) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF04073(tRNA_edit) | 4 | ASP A 356ASN A 372ASP A 251GLU A 250 | None | 1.14A | 4fevB-5ucmA:2.4 | 4fevB-5ucmA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vis | DIHYDROPTEROATESYNTHASE (soil metagenome) |
PF00809(Pterin_bind) | 4 | ASP A 106ASP A 86ASP A 136GLU A 63 | None | 1.18A | 4fevB-5visA:undetectable | 4fevB-5visA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wzr | ALPHA-N-ACETYLGALACTOSAMINIDASE (Bifidobacteriumbifidum) |
PF11308(Glyco_hydro_129) | 4 | ASP A 561ASP A 322ASP A 371ASP A 330 | DJN A 702 (-2.9A) CA A 703 (-2.1A)DJN A 702 (-3.1A)DJN A 702 (-2.6A) | 1.19A | 4fevB-5wzrA:undetectable | 4fevB-5wzrA:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zal | ENDORIBONUCLEASEDICER (Homo sapiens) |
no annotation | 4 | ASP A1810ASN A1742ASP A1709GLU A1705 | None | 0.95A | 4fevB-5zalA:undetectable | 4fevB-5zalA:13.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c8q | NH(3)-DEPENDENTNAD(+) SYNTHETASE (Enterococcusfaecalis) |
no annotation | 4 | ASP A 53ASP A 162ASP A 236GLU A 166 | None | 1.14A | 4fevB-6c8qA:undetectable | 4fevB-6c8qA:15.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cey | BIFUNCTIONAL AAC/APH (Staphylococcusaureus) |
no annotation | 4 | ASP A 396ASP A 393ASP A 213GLU A 240 | MG A 702 ( 4.8A) MG A 702 (-1.7A)NoneGNP A 500 ( 4.4A) | 1.17A | 4fevB-6ceyA:17.5 | 4fevB-6ceyA:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fhv | GLUCOAMYLASE (Penicilliumoxalicum) |
no annotation | 4 | ASP A 345ASP A 210GLU A 436ASP A 281 | NoneNoneB3P A 652 ( 4.6A)None | 0.95A | 4fevB-6fhvA:undetectable | 4fevB-6fhvA:12.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fhw | GLUCOAMYLASE P (Amorphothecaresinae) |
no annotation | 4 | ASP A 339ASP A 205GLU A 432ASP A 275 | NoneNoneACR A 801 (-4.4A)None | 1.03A | 4fevB-6fhwA:undetectable | 4fevB-6fhwA:15.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6frv | GLUCOAMYLASE (Aspergillusniger) |
no annotation | 4 | ASP A 333ASP A 200GLU A 424ASP A 269 | None | 1.05A | 4fevB-6frvA:undetectable | 4fevB-6frvA:17.58 |