SIMILAR PATTERNS OF AMINO ACIDS FOR 4FEU_D_KAND301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqb PROTEIN (AUREOLYSIN)

(Staphylococcus
aureus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 ASP A 140
ASP A 128
GLU A 145
GLU A 187
 CA  A 351 (-3.3A)
None
ZN  A 350 ( 4.6A)
CA  A 351 ( 2.3A)
 0.92A 4feuD-1bqbA:
undetectable		 4feuD-1bqbA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d3y DNA TOPOISOMERASE VI
A SUBUNIT

(Methanocaldococcus
jannaschii) 		PF04406
(TP6A_N) 		4 ASP A 251
ASP A 249
ASP A 305
GLU A 303
 MG  A 371 ( 4.1A)
MG  A 371 (-3.2A)
None
None
 1.05A 4feuD-1d3yA:
undetectable		 4feuD-1d3yA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 ASP A 577
ASP A 562
ASN A 318
GLU A 311
 None
 1.11A 4feuD-1dedA:
2.1		 4feuD-1dedA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 ASP A 144
ASP A 447
ASP A 411
GLU A 170
 None
 1.12A 4feuD-1f4hA:
0.0		 4feuD-1f4hA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 ASP 1 268
ASN 1  66
GLU 1  32
ASP 1  38
GLU 1  39
 None
 1.43A 4feuD-1gt91:
undetectable		 4feuD-1gt91:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 ASP A 213
ASP A 138
ASP A 136
ASN A 100
 AMI  A1388 ( 2.9A)
AMI  A1388 (-3.1A)
AMI  A1388 ( 4.9A)
NAA  A1387 (-3.9A)
 1.07A 4feuD-1hkkA:
0.0		 4feuD-1hkkA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ASP A 296
ASP A  29
ASP A 303
GLU A  97
 None
 1.09A 4feuD-1itzA:
undetectable		 4feuD-1itzA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5s URONATE ISOMERASE

(Thermotoga
maritima) 		PF02614
(UxaC) 		4 ASP A 370
ASP A  55
ASN A  95
GLU A  99
 None
 1.06A 4feuD-1j5sA:
undetectable		 4feuD-1j5sA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmm PROTEIN I/II
V-REGION

(Streptococcus
mutans) 		PF08363
(GbpC) 		4 ASP A 760
ASP A 554
ASP A 555
ASN A 699
 NA  A3001 ( 4.4A)
None
None
NA  A3001 (-3.4A)
 1.10A 4feuD-1jmmA:
undetectable		 4feuD-1jmmA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jtd BETA-LACTAMASE
INHIBITOR PROTEIN II

(Streptomyces
exfoliatus) 		PF13540
(RCC1_2) 		4 ASP B 167
ASP B 131
GLU B 268
ASP B 170
 None
 1.09A 4feuD-1jtdB:
undetectable		 4feuD-1jtdB:
24.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1l8t AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Enterococcus
faecalis) 		PF01636
(APH) 		4 ASP A 190
ASP A 208
ASP A 261
GLU A 160
 KAN  A   1 (-3.2A)
MG  A 302 (-2.1A)
KAN  A   1 (-3.8A)
KAN  A   1 (-3.2A)
 1.05A 4feuD-1l8tA:
26.9		 4feuD-1l8tA:
31.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1l8t AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Enterococcus
faecalis) 		PF01636
(APH) 		4 ASP A 190
ASP A 208
ASP A 261
GLU A 262
 KAN  A   1 (-3.2A)
MG  A 302 (-2.1A)
KAN  A   1 (-3.8A)
KAN  A   1 (-3.1A)
 0.38A 4feuD-1l8tA:
26.9		 4feuD-1l8tA:
31.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1l8t AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Enterococcus
faecalis) 		PF01636
(APH) 		4 ASP A 190
ASP A 208
GLU A 230
ASP A 261
 KAN  A   1 (-3.2A)
MG  A 302 (-2.1A)
KAN  A   1 (-2.8A)
KAN  A   1 (-3.8A)
 0.53A 4feuD-1l8tA:
26.9		 4feuD-1l8tA:
31.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nd4 AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Klebsiella
pneumoniae) 		PF01636
(APH) 		6 ASP A 157
ASP A 159
ASP A 190
GLU A 230
ASP A 261
GLU A 262
 KAN  A1300 (-3.7A)
KAN  A1300 (-3.2A)
KAN  A1300 ( 2.8A)
KAN  A1300 (-4.1A)
KAN  A1300 (-3.8A)
KAN  A1300 (-3.1A)
 0.77A 4feuD-1nd4A:
30.6		 4feuD-1nd4A:
33.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ASP A 320
ASP A 296
ASN A 347
GLU A  47
GLU A 377
 MG  A 438 ( 3.1A)
MG  A 438 ( 4.8A)
None
None
None
 1.49A 4feuD-1p43A:
undetectable		 4feuD-1p43A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 ASP X 285
ASP X 396
ASP X 400
GLU X 286
 MG  X 782 (-3.7A)
ADP  X 780 (-4.1A)
None
MG  X 782 ( 4.4A)
 0.87A 4feuD-1r6bX:
undetectable		 4feuD-1r6bX:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		5 ASP A 457
ASN A 255
GLU A 221
ASP A 227
GLU A 228
 None
 1.33A 4feuD-1t1eA:
2.6		 4feuD-1t1eA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 ASP A 671
ASP A 264
GLU A 766
GLU A 672
 None
 1.00A 4feuD-1ut9A:
undetectable		 4feuD-1ut9A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)

(Thermoproteus
tenax) 		PF00171
(Aldedh) 		4 ASP A 173
ASP A 298
ASP A 424
GLU A 115
 NAD  A1503 ( 4.8A)
None
None
None
 0.88A 4feuD-1uxtA:
undetectable		 4feuD-1uxtA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Escherichia
coli) 		PF02540
(NAD_synthase) 		4 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 None
 1.08A 4feuD-1wxfA:
undetectable		 4feuD-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		4 ASP A  52
ASP A  44
ASP A 110
GLU A 109
 CA  A 601 (-3.5A)
CA  A 601 (-3.3A)
None
None
 1.05A 4feuD-1wzaA:
4.0		 4feuD-1wzaA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		4 ASP A 349
ASP A 207
GLU A 456
ASP A 288
 None
None
ACR  A 995 ( 4.6A)
None
 0.99A 4feuD-2f6dA:
undetectable		 4feuD-2f6dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgy CARBOXYSOME SHELL
POLYPEPTIDE

(Halothiobacillus
neapolitanus) 		PF08936
(CsoSCA) 		4 ASP A 423
ASP A 209
ASP A 169
GLU A 427
 None
 0.94A 4feuD-2fgyA:
0.4		 4feuD-2fgyA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k0z UNCHARACTERIZED
PROTEIN HP1203

(Helicobacter
pylori) 		PF00581
(Rhodanese) 		4 ASP A  43
ASN A  42
GLU A  24
GLU A  45
 None
 0.91A 4feuD-2k0zA:
undetectable		 4feuD-2k0zA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2por PORIN

(Rhodobacter
capsulatus) 		PF13609
(Porin_4) 		4 ASP A  85
ASP A  74
ASP A  58
ASP A 108
 CA  A 302 ( 4.3A)
None
None
CA  A 302 (-3.3A)
 0.96A 4feuD-2porA:
undetectable		 4feuD-2porA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Bacillus
anthracis) 		PF02540
(NAD_synthase) 		4 ASP A  51
ASP A 159
ASP A 233
GLU A 163
 APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
 1.07A 4feuD-2pz8A:
undetectable		 4feuD-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3) 		4 ASP A 903
ASP A 894
ASP A 886
ASP A 907
 CA  A1174 ( 2.5A)
None
CA  A   7 (-3.1A)
CA  A   8 (-3.1A)
 1.08A 4feuD-2rhpA:
undetectable		 4feuD-2rhpA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		4 ASP A 313
ASP A 176
GLU A 404
ASP A 249
 None
None
BTB  A 620 (-4.0A)
None
 0.88A 4feuD-2vn7A:
undetectable		 4feuD-2vn7A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w20 SIALIDASE A

(Streptococcus
pneumoniae) 		PF13088
(BNR_2) 		4 ASP A 372
ASP A 364
GLU A 768
ASP A 434
 None
 1.04A 4feuD-2w20A:
undetectable		 4feuD-2w20A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wba TRYPANOTHIONE
REDUCTASE

(Trypanosoma
brucei) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ASP A 432
ASP A  71
ASN A 245
GLU A  75
 None
 1.04A 4feuD-2wbaA:
undetectable		 4feuD-2wbaA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whk MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Bacillus
subtilis) 		PF02156
(Glyco_hydro_26) 		4 ASP A  43
GLU A 266
ASP A 300
GLU A 301
 None
TRS  A1338 (-2.7A)
None
None
 1.09A 4feuD-2whkA:
undetectable		 4feuD-2whkA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18

(Monosiga
brevicollis) 		PF00995
(Sec1) 		4 ASP A  56
ASP A  30
ASP A  86
ASN A  79
 None
 0.94A 4feuD-2xheA:
undetectable		 4feuD-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yeq ALKALINE PHOSPHATASE
D

(Bacillus
subtilis) 		PF09423
(PhoD)
PF16655
(PhoD_N) 		4 ASP A 289
ASP A 380
GLU A 504
GLU A 223
 None
CA  A1525 ( 3.4A)
EDO  A 540 (-3.7A)
None
 1.10A 4feuD-2yeqA:
undetectable		 4feuD-2yeqA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		4 ASP A 665
ASP A 878
ASP A 907
GLU A 694
 None
 1.06A 4feuD-2yocA:
undetectable		 4feuD-2yocA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ASP A 328
GLU A  26
ASP A  29
GLU A  30
 None
 1.07A 4feuD-2z1qA:
0.5		 4feuD-2z1qA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5l TYLACTONE SYNTHASE
STARTER MODULE AND
MODULES 1 & 2

(Streptomyces
fradiae) 		PF08659
(KR) 		4 ASP A 326
ASN A 377
GLU A 154
GLU A 423
 None
 1.03A 4feuD-2z5lA:
undetectable		 4feuD-2z5lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8y ENDO-PECTATE LYASE

(Dickeya
chrysanthemi) 		PF03211
(Pectate_lyase) 		4 ASP A 133
ASP A  89
ASN A 163
GLU A 185
 None
 1.03A 4feuD-3b8yA:
undetectable		 4feuD-3b8yA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be5 PUTATIVE IRON
COMPOUND-BINDING
PROTEIN OF ABC
TRANSPORTER FAMILY

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 ASP A  85
ASP A  46
ASP A  70
GLU A 285
 None
 1.07A 4feuD-3be5A:
undetectable		 4feuD-3be5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF13247
(Fer4_11)
PF14710
(Nitr_red_alph_N)
PF14711
(Nitr_red_bet_C) 		4 ASP A  33
ASP B 482
ASP B 500
GLU B 472
 None
 1.06A 4feuD-3egwA:
undetectable		 4feuD-3egwA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoe PYRUVATE KINASE

(Toxoplasma
gondii) 		PF00224
(PK)
PF02887
(PK_C) 		4 ASP A 162
ASP A 101
ASN A 192
ASP A 281
 None
 1.12A 4feuD-3eoeA:
undetectable		 4feuD-3eoeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger) 		PF00723
(Glyco_hydro_15) 		4 ASP A 333
ASP A 200
GLU A 424
ASP A 269
 None
 0.93A 4feuD-3eqaA:
undetectable		 4feuD-3eqaA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3t VACUOLAR TRANSPORTER
CHAPERONE 4

(Saccharomyces
cerevisiae) 		PF09359
(VTC) 		4 ASP A 469
ASP A 416
ASP A 413
GLU A 245
 None
None
None
PO4  A1003 (-3.6A)
 1.01A 4feuD-3g3tA:
undetectable		 4feuD-3g3tA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1

(Streptomyces
antibioticus) 		PF16670
(PI-PLC-C1) 		4 ASP A  62
ASP A 287
ASN A  38
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.90A 4feuD-3h4xA:
undetectable		 4feuD-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7n NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		PF11715
(Nup160) 		4 ASP A   8
ASN A 383
ASP A 388
GLU A 392
 None
 1.12A 4feuD-3h7nA:
undetectable		 4feuD-3h7nA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmq NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Salmonella
enterica) 		PF02540
(NAD_synthase) 		4 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 SO4  A 276 (-4.9A)
None
None
None
 1.03A 4feuD-3hmqA:
undetectable		 4feuD-3hmqA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Colwellia
psychrerythraea) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ASP A 324
ASN A 312
GLU A 295
ASP A 310
 NA  A 491 (-3.0A)
NA  A 491 (-2.6A)
None
FAD  A 490 (-3.0A)
 0.96A 4feuD-3ic9A:
undetectable		 4feuD-3ic9A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iox AGI/II

(Streptococcus
mutans) 		PF06696
(Strep_SA_rep)
PF08363
(GbpC) 		4 ASP A 760
ASP A 554
ASP A 555
ASN A 699
 PMS  A 900 (-3.6A)
None
None
CA  A 903 (-3.1A)
 1.09A 4feuD-3ioxA:
undetectable		 4feuD-3ioxA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES17
40S RIBOSOMAL
PROTEIN US2

(Plasmodium
falciparum) 		PF00318
(Ribosomal_S2)
PF00833
(Ribosomal_S17e) 		4 ASP C 148
ASP C 150
GLU W  99
GLU C 168
 None
 1.00A 4feuD-3j7aC:
undetectable		 4feuD-3j7aC:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks5 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Agrobacterium
fabrum) 		PF03009
(GDPD) 		4 ASP A  36
ASP A  50
ASP A 231
ASP A  16
 FE  A 250 (-2.6A)
EDO  A 256 (-3.0A)
None
EDO  A 256 (-3.5A)
 1.10A 4feuD-3ks5A:
undetectable		 4feuD-3ks5A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oig ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Bacillus
subtilis) 		PF13561
(adh_short_C2) 		4 ASP A  57
ASP A  60
ASP A 229
GLU A   6
 None
 1.04A 4feuD-3oigA:
undetectable		 4feuD-3oigA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN

(Pyrococcus
abyssi) 		PF00152
(tRNA-synt_2) 		4 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.12A 4feuD-3p8tA:
1.9		 4feuD-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		4 ASP A  22
ASP A 906
ASN A 887
GLU A 891
 None
 1.03A 4feuD-3pieA:
undetectable		 4feuD-3pieA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2v CADHERIN-1

(Mus musculus) 		PF00028
(Cadherin) 		4 ASP A 325
ASP A 415
ASP A 360
GLU A 291
 CA  A 607 (-3.2A)
CA  A 609 (-3.0A)
CA  A 609 ( 3.4A)
CA  A 607 ( 2.7A)
 1.07A 4feuD-3q2vA:
undetectable		 4feuD-3q2vA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0p DNA POLYMERASE III,
BETA SUBUNIT

([Eubacterium]
rectale) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 ASP A 352
ASP A 311
ASN A 337
GLU A 335
 None
 0.77A 4feuD-3t0pA:
undetectable		 4feuD-3t0pA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 ASP A 350
ASP A 352
GLU A 325
GLU A 339
 CA  A 446 (-3.3A)
CA  A 446 (-3.0A)
CA  A 447 (-2.1A)
None
 1.07A 4feuD-3u0kA:
undetectable		 4feuD-3u0kA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 1
H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 4

(Saccharomyces
cerevisiae) 		PF01472
(PUA)
PF01509
(TruB_N)
PF04410
(Gar1)
PF08068
(DKCLD)
PF16198
(TruB_C_2) 		4 ASP A 138
ASP A 135
GLU C 105
GLU C  87
 None
 1.07A 4feuD-3uaiA:
undetectable		 4feuD-3uaiA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		4 ASP A  88
ASP A 211
ASP A 230
GLU A 233
 IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
 1.00A 4feuD-3wjoA:
undetectable		 4feuD-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 ASP A 691
ASP A 727
ASP A 269
ASP A 257
 MG  A1771 ( 2.7A)
MG  A1769 ( 2.5A)
MG  A1768 ( 3.9A)
MG  A1767 (-2.5A)
 0.88A 4feuD-4a01A:
undetectable		 4feuD-4a01A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amf PHOX

(Pseudomonas
fluorescens) 		PF05787
(DUF839) 		4 ASP A 494
ASP A  66
ASN A 195
GLU A 273
 CA  A1594 (-2.6A)
EDO  A1598 ( 3.7A)
ACP  A1589 (-3.4A)
FEO  A1595 ( 2.4A)
 1.01A 4feuD-4amfA:
undetectable		 4feuD-4amfA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		4 ASP A 202
ASP A 696
ASP A 488
ASP A 485
 MG  A1729 (-2.2A)
PO4  A1728 ( 3.3A)
PO4  A1727 (-3.3A)
None
 0.82A 4feuD-4av6A:
undetectable		 4feuD-4av6A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddd IMMUNOGENIC PROTEIN

(Ehrlichia
chaffeensis) 		PF16868
(NMT1_3) 		4 ASP A  94
ASN A 148
GLU A 179
ASP A 199
 None
 1.04A 4feuD-4dddA:
undetectable		 4feuD-4dddA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee9 ENDOGLUCANASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		4 ASP A 260
ASP A 257
ASN A 267
GLU A 268
 None
None
TRS  A 402 (-3.0A)
None
 1.02A 4feuD-4ee9A:
0.6		 4feuD-4ee9A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		4 ASP B1000
ASP B1080
ASN B1032
GLU B1004
 None
 0.92A 4feuD-4fhnB:
1.5		 4feuD-4fhnB:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		4 ASP A 403
ASP A 258
ASP A 257
ASN A 288
 None
MN  A 704 (-2.3A)
None
None
 1.03A 4feuD-4fixA:
undetectable		 4feuD-4fixA:
19.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gkh AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB

(Acinetobacter
baumannii) 		PF01636
(APH) 		8 ASP A 165
ASP A 167
ASP A 198
ASP A 216
ASN A 234
GLU A 238
ASP A 268
GLU A 269
 KAN  A 301 (-3.7A)
KAN  A 301 (-3.3A)
KAN  A 301 (-3.0A)
0J9  A 302 ( 3.7A)
KAN  A 301 (-3.9A)
None
KAN  A 301 (-3.8A)
KAN  A 301 (-3.2A)
 0.66A 4feuD-4gkhA:
38.2		 4feuD-4gkhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT

(Streptococcus
pneumoniae) 		PF13458
(Peripla_BP_6) 		4 ASP A 159
ASP A 143
GLU A  48
ASP A 262
 None
None
None
ILE  A 401 (-2.8A)
 1.07A 4feuD-4gnrA:
undetectable		 4feuD-4gnrA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		4 ASP A 226
GLU A 148
ASP A 244
GLU A 247
 None
 1.08A 4feuD-4gp1A:
undetectable		 4feuD-4gp1A:
22.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus) 		PF01636
(APH) 		4 ASP A 153
ASP A 184
ASP A 264
GLU A 265
 None
 0.47A 4feuD-4h05A:
28.8		 4feuD-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus) 		PF01636
(APH) 		4 ASP A 153
ASP A 204
ASP A 264
GLU A 265
 None
 0.88A 4feuD-4h05A:
28.8		 4feuD-4h05A:
34.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE

(Pseudoalteromonas
atlantica) 		PF00348
(polyprenyl_synt) 		4 ASP A 212
GLU A 146
ASP A 230
GLU A 233
 None
 1.08A 4feuD-4jxyA:
undetectable		 4feuD-4jxyA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfn GALACTOSE-6-PHOSPHAT
E ISOMERASE SUBUNIT
A
GALACTOSE-6-PHOSPHAT
E ISOMERASE SUBUNIT
B

(Lactobacillus
rhamnosus) 		PF02502
(LacAB_rpiB) 		4 ASP B  88
ASP A  63
ASP A   8
GLU A  85
 None
 1.10A 4feuD-4lfnB:
undetectable		 4feuD-4lfnB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlz SJCHGC07024 PROTEIN

(Schistosoma
japonicum) 		PF00719
(Pyrophosphatase) 		4 ASP A 118
GLU A  60
ASP A 113
GLU A 148
 CO  A 401 (-2.5A)
None
CO  A 401 ( 2.8A)
None
 1.10A 4feuD-4qlzA:
undetectable		 4feuD-4qlzA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Rhizobium etli) 		PF13407
(Peripla_BP_4) 		4 ASP A 243
ASP A  67
ASN A 132
ASP A 115
 RIP  A 401 (-2.6A)
None
None
RIP  A 401 (-2.8A)
 1.11A 4feuD-4ry0A:
undetectable		 4feuD-4ry0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN SAC3

(Saccharomyces
cerevisiae) 		PF03399
(SAC3_GANP) 		4 ASP A 550
ASP A 266
ASP A 270
GLU A 309
 None
 1.08A 4feuD-4trqA:
undetectable		 4feuD-4trqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxv SEPTATION RING
FORMATION REGULATOR
EZRA

(Bacillus
subtilis) 		PF06160
(EzrA) 		4 ASP A  88
ASP A 109
ASN A 102
ASP A  30
 None
 0.89A 4feuD-4uxvA:
undetectable		 4feuD-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Pseudomonas
aeruginosa) 		PF02540
(NAD_synthase) 		4 ASP A  56
ASP A 168
ASP A 242
GLU A 172
 None
 1.03A 4feuD-4xfdA:
undetectable		 4feuD-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3y THERMOLYSIN

(Bacillus
thermoproteolyticus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 ASP A 138
ASP A 126
GLU A 143
GLU A 190
 CA  A1318 (-3.2A)
None
VAL  A1322 (-3.2A)
CA  A1318 ( 2.2A)
 0.88A 4feuD-5a3yA:
undetectable		 4feuD-5a3yA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5enz UDP-GLCNAC
2-EPIMERASE

(Staphylococcus
aureus) 		PF02350
(Epimerase_2) 		4 ASP A 176
ASN A 346
GLU A 287
ASP A 350
 None
 1.01A 4feuD-5enzA:
undetectable		 4feuD-5enzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqd UDP-GALACTOPYRANOSE
MUTASE

(Mycolicibacterium
smegmatis) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 ASP A 261
ASP A 233
ASP A 236
GLU A 358
 None
FAD  A 501 (-3.6A)
None
None
 0.90A 4feuD-5eqdA:
undetectable		 4feuD-5eqdA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbb NUCLEASE S1

(Aspergillus
oryzae) 		PF02265
(S1-P1_nuclease) 		4 ASP A 139
ASN A  23
GLU A 177
ASP A  65
 ZN  A 402 (-2.5A)
BTB  A1002 (-3.8A)
BTB  A1002 (-2.8A)
PO4  A 601 ( 2.7A)
 1.10A 4feuD-5fbbA:
undetectable		 4feuD-5fbbA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg0 E3 UBIQUITIN-PROTEIN
LIGASE LISTERIN

(Saccharomyces
cerevisiae) 		no annotation 4 ASP A  15
ASP A  31
ASP A 243
ASN A  28
 None
None
K  A 501 ( 4.7A)
None
 1.05A 4feuD-5fg0A:
1.5		 4feuD-5fg0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxn THERMOLYSIN

(Bacillus
thermoproteolyticus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 ASP A 138
ASP A 126
GLU A 143
GLU A 190
 CA  A1321 (-3.2A)
None
VAL  A1318 (-3.1A)
CA  A1321 ( 2.2A)
 0.89A 4feuD-5fxnA:
undetectable		 4feuD-5fxnA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghs SSDNA-SPECIFIC
EXONUCLEASE

(Thermococcus
kodakarensis) 		PF02272
(DHHA1) 		4 ASP A  83
ASP A 105
GLU A 169
ASP A  34
 None
 1.00A 4feuD-5ghsA:
undetectable		 4feuD-5ghsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4a ARGONAUTE PROTEIN

(Marinitoga
piezophila) 		no annotation 4 ASP A 630
ASP A 446
ASP A 516
GLU A 632
 None
None
None
U  B   1 ( 3.8A)
 1.05A 4feuD-5i4aA:
undetectable		 4feuD-5i4aA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i85 SPHINGOMYELIN
PHOSPHODIESTERASE

(Homo sapiens) 		PF00149
(Metallophos) 		4 ASP A 278
ASP A 141
ASN A 318
GLU A 320
 ZN  A 714 (-2.6A)
None
ZN  A 714 ( 2.6A)
None
 1.12A 4feuD-5i85A:
undetectable		 4feuD-5i85A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iqk BETA-LACTAMASE RM3

(uncultured
bacterium) 		PF00753
(Lactamase_B) 		4 ASP A 112
ASP A 210
GLU A 256
ASP A  77
 ZN  A 402 (-2.4A)
None
None
None
 1.07A 4feuD-5iqkA:
undetectable		 4feuD-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iry DESMOCOLLIN-1

(Homo sapiens) 		PF00028
(Cadherin) 		4 ASP A 348
ASP A 516
ASP A 465
GLU A 402
 CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
 0.95A 4feuD-5iryA:
undetectable		 4feuD-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldt MOMP PORIN

(Campylobacter
jejuni) 		PF05538
(Campylo_MOMP) 		4 ASP A  21
ASP A 155
ASN A  36
GLU A 300
 None
CA  A 501 (-3.3A)
None
None
 1.08A 4feuD-5ldtA:
undetectable		 4feuD-5ldtA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		4 ASP A 593
ASP A 455
ASP A 453
ASN A  61
 None
None
CA  A1203 (-2.4A)
None
 1.12A 4feuD-5mqsA:
undetectable		 4feuD-5mqsA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nx4 PENTALENENE SYNTHASE

(Streptomyces
clavuligerus) 		no annotation 4 ASP A 226
ASP A  79
ASP A  80
GLU A 219
 None
 1.10A 4feuD-5nx4A:
undetectable		 4feuD-5nx4A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8z CAROTENOID OXYGENASE
1

(Neurospora
crassa) 		PF03055
(RPE65) 		4 ASP A 388
ASP A 518
ASP A 520
ASN A 460
 None
 1.11A 4feuD-5u8zA:
undetectable		 4feuD-5u8zA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5y RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN6

(Saccharomyces
cerevisiae) 		PF10214
(Rrn6) 		4 ASP O 183
ASP O 409
ASP O 410
GLU O 509
 None
 0.99A 4feuD-5w5yO:
undetectable		 4feuD-5w5yO:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeo CYSTEINE SYNTHASE

(Fusobacterium
nucleatum) 		no annotation 4 ASP A 247
ASP A 246
ASP A 276
GLU A 280
 None
None
PEG  A 408 (-3.7A)
None
 1.04A 4feuD-5xeoA:
undetectable		 4feuD-5xeoA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1

(Homo sapiens) 		PF00005
(ABC_tran)
PF12698
(ABC2_membrane_3) 		4 ASP A 585
ASP A 575
ASP A 629
ASP A 571
 None
 1.12A 4feuD-5xjyA:
2.2		 4feuD-5xjyA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER

(Homo sapiens) 		no annotation 4 ASP A1810
ASN A1742
ASP A1709
GLU A1705
 None
 0.97A 4feuD-5zalA:
undetectable		 4feuD-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Mus musculus) 		no annotation 4 ASP A 343
ASP A 426
ASN A 239
GLU A 266
 DGT  A 701 (-2.6A)
DGT  A 701 ( 4.5A)
DGT  A 701 (-3.7A)
DGT  A 701 (-4.2A)
 0.93A 4feuD-6brkA:
undetectable		 4feuD-6brkA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Enterococcus
faecalis) 		no annotation 4 ASP A  53
ASP A 162
ASP A 236
GLU A 166
 None
 1.10A 4feuD-6c8qA:
undetectable		 4feuD-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhv GLUCOAMYLASE

(Penicillium
oxalicum) 		no annotation 4 ASP A 345
ASP A 210
GLU A 436
ASP A 281
 None
None
B3P  A 652 ( 4.6A)
None
 0.91A 4feuD-6fhvA:
undetectable		 4feuD-6fhvA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae) 		no annotation 4 ASP A 339
ASP A 205
GLU A 432
ASP A 275
 None
None
ACR  A 801 (-4.4A)
None
 1.02A 4feuD-6fhwA:
undetectable		 4feuD-6fhwA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 4 ASP A 333
ASP A 200
GLU A 424
ASP A 269
 None
 1.00A 4feuD-6frvA:
undetectable		 4feuD-6frvA:
17.58