SIMILAR PATTERNS OF AMINO ACIDS FOR 4FAK_A_SAMA201_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azz COLLAGENASE

(Leptuca
pugilator) 		PF00089
(Trypsin) 		5 LEU A  53
ILE A 106
ILE A 212
GLY A 196
GLY A  43
 None
 0.96A 4fakA-1azzA:
undetectable		 4fakA-1azzA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azz COLLAGENASE

(Leptuca
pugilator) 		PF00089
(Trypsin) 		5 LEU A  53
ILE A 106
ILE A 212
GLY A 197
GLY A  43
 None
 0.93A 4fakA-1azzA:
undetectable		 4fakA-1azzA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bx0 PROTEIN
(FERREDOXIN:NADP+
OXIDOREDUCTASE)

(Spinacia
oleracea) 		PF00175
(NAD_binding_1) 		6 LEU A 202
ILE A 247
ILE A 174
GLY A 173
GLY A 273
PHE A 231
 None
 1.23A 4fakA-1bx0A:
1.1		 4fakA-1bx0A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		5 LEU A 349
ILE A 430
GLY A 431
GLY A 433
SER A 397
 None
None
GDP  A 500 (-3.2A)
GDP  A 500 (-3.2A)
None
 0.98A 4fakA-1dj3A:
undetectable		 4fakA-1dj3A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 LEU A  53
ILE A 106
ILE A 212
GLY A 196
GLY A  43
 None
 1.02A 4fakA-1fizA:
undetectable		 4fakA-1fizA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 LEU A  53
ILE A 106
ILE A 212
GLY A 197
GLY A  43
 None
 0.94A 4fakA-1fizA:
undetectable		 4fakA-1fizA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuj PR3

(Homo sapiens) 		PF00089
(Trypsin) 		5 LEU A  53
ILE A 106
ILE A 212
GLY A 197
GLY A  43
 None
 0.97A 4fakA-1fujA:
undetectable		 4fakA-1fujA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
CYTOCHROME B556(FDN)
SUBUNIT

(Escherichia
coli) 		PF01292
(Ni_hydr_CYTB) 		5 ILE C 134
ILE C  62
GLY C  61
PHE C 139
THR C 130
 HEM  C 809 (-4.8A)
None
HEM  C 809 (-3.5A)
None
None
 0.86A 4fakA-1kqfC:
undetectable		 4fakA-1kqfC:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU C 353
ILE C 385
GLY C 387
PHE C 355
THR C 423
 None
 1.07A 4fakA-1n8yC:
undetectable		 4fakA-1n8yC:
13.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns5 HYPOTHETICAL PROTEIN
YBEA

(Escherichia
coli) 		PF02590
(SPOUT_MTase) 		5 ILE A  74
GLY A 104
GLY A 107
SER A 123
THR A 126
 None
 0.97A 4fakA-1ns5A:
23.4		 4fakA-1ns5A:
33.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns5 HYPOTHETICAL PROTEIN
YBEA

(Escherichia
coli) 		PF02590
(SPOUT_MTase) 		7 LEU A  72
ILE A  74
ILE A 102
GLY A 103
GLY A 107
SER A 123
THR A 126
 None
 0.54A 4fakA-1ns5A:
23.4		 4fakA-1ns5A:
33.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844

(Thermotoga
maritima) 		PF02590
(SPOUT_MTase) 		5 GLY A 101
GLY A 104
SER A 120
THR A 123
PHE A 124
 None
 1.06A 4fakA-1o6dA:
22.1		 4fakA-1o6dA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844

(Thermotoga
maritima) 		PF02590
(SPOUT_MTase) 		6 ILE A  99
GLY A 100
GLY A 104
SER A 120
THR A 123
PHE A 124
 None
 0.34A 4fakA-1o6dA:
22.1		 4fakA-1o6dA:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		5 ILE A 536
GLY A 537
GLY A 538
PHE A 741
MET A  58
 None
LMS  A1817 ( 3.7A)
LMS  A1817 ( 4.1A)
None
None
 1.02A 4fakA-1obhA:
undetectable		 4fakA-1obhA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		5 LEU A 501
ILE A 504
GLY A 505
PHE A 497
SER A 496
 None
None
None
None
HEA  A 601 ( 4.2A)
 0.85A 4fakA-1qleA:
undetectable		 4fakA-1qleA:
14.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA

(Bacillus
subtilis) 		PF02590
(SPOUT_MTase) 		6 ILE A  78
GLY A 109
GLY A 112
SER A 128
THR A 131
PHE A 132
 None
 1.03A 4fakA-1to0A:
25.9		 4fakA-1to0A:
60.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA

(Bacillus
subtilis) 		PF02590
(SPOUT_MTase) 		7 LEU A  76
GLY A 108
GLY A 109
PHE A 127
THR A 131
PHE A 132
MET A 137
 None
 1.33A 4fakA-1to0A:
25.9		 4fakA-1to0A:
60.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA

(Bacillus
subtilis) 		PF02590
(SPOUT_MTase) 		10 LEU A  76
ILE A  78
ILE A 107
GLY A 108
GLY A 112
PHE A 127
SER A 128
THR A 131
PHE A 132
MET A 137
 None
 0.40A 4fakA-1to0A:
25.9		 4fakA-1to0A:
60.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis) 		PF02595
(Gly_kinase) 		5 LEU A 251
ILE A 259
ILE A 247
GLY A 246
GLY A 242
 None
 0.99A 4fakA-1to6A:
2.9		 4fakA-1to6A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		5 LEU A 220
ILE A 326
GLY A 225
GLY A 224
SER A 215
 None
 0.85A 4fakA-1ukcA:
undetectable		 4fakA-1ukcA:
14.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vh0 HYPOTHETICAL UPF0247
PROTEIN
SAV0024/SA0023

(Staphylococcus
aureus) 		PF02590
(SPOUT_MTase) 		5 GLY A 109
GLY A 112
SER A 128
THR A 131
PHE A 132
 None
 0.99A 4fakA-1vh0A:
29.2		 4fakA-1vh0A:
96.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vh0 HYPOTHETICAL UPF0247
PROTEIN
SAV0024/SA0023

(Staphylococcus
aureus) 		PF02590
(SPOUT_MTase) 		8 LEU A  76
GLY A 108
GLY A 109
PHE A 127
SER A 128
THR A 131
PHE A 132
MET A 137
 None
 1.29A 4fakA-1vh0A:
29.2		 4fakA-1vh0A:
96.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vh0 HYPOTHETICAL UPF0247
PROTEIN
SAV0024/SA0023

(Staphylococcus
aureus) 		PF02590
(SPOUT_MTase) 		10 LEU A  76
ILE A  78
ILE A 107
GLY A 108
GLY A 112
PHE A 127
SER A 128
THR A 131
PHE A 132
MET A 137
 None
 0.33A 4fakA-1vh0A:
29.2		 4fakA-1vh0A:
96.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wo8 METHYLGLYOXAL
SYNTHASE

(Thermus
thermophilus) 		PF02142
(MGS) 		5 ILE A   7
ILE A  42
GLY A  39
GLY A  36
MET A  16
 None
None
None
SO4  A1001 ( 4.0A)
None
 0.96A 4fakA-1wo8A:
3.2		 4fakA-1wo8A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wo8 METHYLGLYOXAL
SYNTHASE

(Thermus
thermophilus) 		PF02142
(MGS) 		5 LEU A   6
ILE A  42
GLY A  39
GLY A  36
MET A  16
 None
None
None
SO4  A1001 ( 4.0A)
None
 0.81A 4fakA-1wo8A:
3.2		 4fakA-1wo8A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztm FUSION GLYCOPROTEIN

(Human
respirovirus 3) 		PF00523
(Fusion_gly) 		5 LEU A 323
ILE A 316
GLY A 325
GLY A 345
THR A 291
 None
 0.98A 4fakA-1ztmA:
undetectable		 4fakA-1ztmA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		6 LEU A 673
ILE A 396
GLY A 395
GLY A 393
SER A 653
THR A 657
 None
 1.14A 4fakA-2b5mA:
undetectable		 4fakA-2b5mA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5n DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF10433
(MMS1_N) 		5 LEU A 673
ILE A 396
GLY A 395
GLY A 393
SER A 653
 None
 1.05A 4fakA-2b5nA:
undetectable		 4fakA-2b5nA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5n DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF10433
(MMS1_N) 		5 LEU A 673
ILE A 396
GLY A 395
GLY A 393
THR A 657
 None
 0.99A 4fakA-2b5nA:
undetectable		 4fakA-2b5nA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bt7 SIGMA C

(Avian
orthoreovirus) 		PF04582
(Reo_sigmaC) 		5 LEU A 237
ILE A 214
GLY A 235
THR A 281
PHE A 280
 None
 0.97A 4fakA-2bt7A:
undetectable		 4fakA-2bt7A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 397
ILE A 422
ILE A 419
THR A 462
PHE A 463
 None
 1.04A 4fakA-2cgjA:
undetectable		 4fakA-2cgjA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF01113
(DapB_N)
PF02800
(Gp_dh_C) 		5 LEU A  77
ILE A  83
GLY A   6
GLY A  31
SER A  55
 None
 0.99A 4fakA-2czcA:
undetectable		 4fakA-2czcA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7v AECTYLCITRULLINE
DEACETYLASE

(Xanthomonas
campestris) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A  37
ILE A  33
GLY A  32
GLY A  31
PHE A 126
 None
 1.03A 4fakA-2f7vA:
undetectable		 4fakA-2f7vA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hr7 INSULIN RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 ILE A 336
GLY A 338
GLY A 317
SER A 326
THR A 320
 None
None
None
None
SO4  A 607 (-4.4A)
 0.97A 4fakA-2hr7A:
undetectable		 4fakA-2hr7A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ii1 ACETAMIDASE

(Bacillus
halodurans) 		PF03069
(FmdA_AmdA) 		5 LEU A 204
ILE A  81
ILE A  76
GLY A 163
PHE A  31
 None
 0.88A 4fakA-2ii1A:
undetectable		 4fakA-2ii1A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6n ATP-DEPENDENT RNA
HELICASE DDX41

(Homo sapiens) 		PF00271
(Helicase_C) 		5 LEU A 436
ILE A 505
ILE A 501
PHE A 438
THR A 533
 None
 0.98A 4fakA-2p6nA:
undetectable		 4fakA-2p6nA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc5 STREPTOGRAMIN B
LACTONASE

(Staphylococcus
cohnii) 		no annotation 5 LEU A 125
ILE A 104
ILE A 131
GLY A 123
THR A  73
 LEU  A 125 ( 0.6A)
ILE  A 104 ( 0.6A)
ILE  A 131 ( 0.7A)
GLY  A 123 ( 0.0A)
THR  A  73 ( 0.8A)
 1.02A 4fakA-2qc5A:
undetectable		 4fakA-2qc5A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmm UPF0217 PROTEIN
AF_1056

(Archaeoglobus
fulgidus) 		PF04013
(Methyltrn_RNA_2) 		5 LEU A 221
ILE A 241
GLY A 242
GLY A 246
SER A 266
 SAM  A 301 (-4.3A)
SAM  A 301 ( 4.8A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.2A)
 0.69A 4fakA-2qmmA:
6.9		 4fakA-2qmmA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv6 GTP CYCLOHYDROLASE
III

(Methanocaldococcus
jannaschii) 		PF05165
(GCH_III) 		5 LEU A 228
ILE A 134
ILE A 231
GLY A 232
GLY A 215
 None
 0.95A 4fakA-2qv6A:
undetectable		 4fakA-2qv6A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r16 NEUREXIN-1-ALPHA

(Bos taurus) 		PF02210
(Laminin_G_2) 		5 LEU A 889
ILE A 887
GLY A 893
SER A 878
THR A 724
 None
 1.02A 4fakA-2r16A:
undetectable		 4fakA-2r16A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrs SIGMA-C CAPSID
PROTEIN

(Avian
orthoreovirus) 		PF04582
(Reo_sigmaC) 		5 LEU A 237
ILE A 214
GLY A 235
THR A 281
PHE A 280
 None
 0.91A 4fakA-2vrsA:
undetectable		 4fakA-2vrsA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8w METHYLGLYOXAL
SYNTHASE

(Thermus sp. GH5) 		PF02142
(MGS) 		5 ILE A   7
ILE A  42
GLY A  39
GLY A  36
MET A  16
 None
None
None
MLI  A1126 ( 4.6A)
None
 1.01A 4fakA-2x8wA:
3.0		 4fakA-2x8wA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8w METHYLGLYOXAL
SYNTHASE

(Thermus sp. GH5) 		PF02142
(MGS) 		5 LEU A   6
ILE A  42
GLY A  39
GLY A  36
MET A  16
 None
None
None
MLI  A1126 ( 4.6A)
None
 0.82A 4fakA-2x8wA:
3.0		 4fakA-2x8wA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4o PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		5 ILE A 151
GLY A 148
GLY A 141
THR A 188
PHE A 216
 None
 0.99A 4fakA-2y4oA:
undetectable		 4fakA-2y4oA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococcus
jannaschii) 		PF04013
(Methyltrn_RNA_2) 		5 LEU X 136
ILE X 155
GLY X 156
GLY X 160
SER X 180
 SAM  X 501 (-4.3A)
SAM  X 501 ( 4.8A)
SAM  X 501 (-3.2A)
SAM  X 501 ( 4.2A)
SAM  X 501 (-4.2A)
 0.86A 4fakA-3ai9X:
6.5		 4fakA-3ai9X:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9k FAB HEAVY CHAIN

(Rattus rattus) 		no annotation 5 ILE H  51
GLY H  50
GLY H  49
PHE H  79
SER H  19
 None
 0.96A 4fakA-3b9kH:
undetectable		 4fakA-3b9kH:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdv UNCHARACTERIZED
PROTEIN DUF1234

(Pectobacterium
atrosepticum) 		PF06821
(Ser_hydrolase) 		5 LEU A  21
ILE A  47
ILE A  78
GLY A  79
GLY A  83
 None
 0.92A 4fakA-3bdvA:
undetectable		 4fakA-3bdvA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beu TRYPSIN

(Streptomyces
griseus) 		PF00089
(Trypsin) 		5 LEU A  53
ILE A 106
ILE A 212
GLY A 196
GLY A  43
 None
 1.00A 4fakA-3beuA:
undetectable		 4fakA-3beuA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beu TRYPSIN

(Streptomyces
griseus) 		PF00089
(Trypsin) 		5 LEU A  53
ILE A 106
ILE A 212
GLY A 197
GLY A  43
 None
 0.88A 4fakA-3beuA:
undetectable		 4fakA-3beuA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF01636
(APH) 		5 LEU A 279
ILE A 289
ILE A 275
GLY A 274
PHE A 291
 None
None
EDO  A 345 ( 4.8A)
None
None
 0.88A 4fakA-3csvA:
undetectable		 4fakA-3csvA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		5 LEU A 556
ILE A 501
ILE A 594
GLY A 593
GLY A 592
 None
 1.02A 4fakA-3eqnA:
undetectable		 4fakA-3eqnA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyi PROTEIN DUF199/WHIA

(Thermotoga
maritima) 		PF02650
(HTH_WhiA)
PF10298
(WhiA_N)
PF14527
(LAGLIDADG_WhiA) 		5 LEU A 118
ILE A 185
GLY A 123
PHE A 114
SER A 113
 None
 1.07A 4fakA-3hyiA:
undetectable		 4fakA-3hyiA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE

(Caenorhabditis
elegans) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		6 ILE A  45
GLY A  46
GLY A  51
SER A  41
THR A  65
PHE A  66
 None
 1.47A 4fakA-3k6jA:
undetectable		 4fakA-3k6jA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhp FERREDOXIN--NADP
REDUCTASE, LEAF
ISOZYME,
CHLOROPLASTIC

(Pisum sativum) 		PF00175
(NAD_binding_1) 		5 ILE A 241
ILE A 168
GLY A 167
GLY A 267
PHE A 225
 None
 0.84A 4fakA-3mhpA:
undetectable		 4fakA-3mhpA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		5 LEU A 905
ILE A 903
GLY A 909
SER A 894
THR A 740
 None
 0.87A 4fakA-3poyA:
undetectable		 4fakA-3poyA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		5 LEU A 889
ILE A 887
GLY A 893
SER A 878
THR A 724
 None
 0.89A 4fakA-3qcwA:
undetectable		 4fakA-3qcwA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5w L-ORNITHINE
5-MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF13434
(K_oxygenase) 		5 LEU A  25
ILE A  23
GLY A  15
GLY A  17
PHE A 120
 None
None
None
FAD  A 450 (-3.4A)
None
 1.00A 4fakA-3s5wA:
undetectable		 4fakA-3s5wA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vo2 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00175
(NAD_binding_1) 		5 ILE A 247
ILE A 174
GLY A 173
GLY A 273
PHE A 231
 None
 0.85A 4fakA-3vo2A:
undetectable		 4fakA-3vo2A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aur LEOA

(Escherichia
coli) 		PF00350
(Dynamin_N) 		5 LEU A 418
ILE A 559
GLY A 420
GLY A  32
SER A 557
 None
 0.98A 4fakA-4aurA:
undetectable		 4fakA-4aurA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btf MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 389
ILE A 387
ILE A 392
PHE A 385
SER A 384
 None
 0.94A 4fakA-4btfA:
undetectable		 4fakA-4btfA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxw FACTOR XA

(Pseudonaja
textilis) 		PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		5 LEU A 207
ILE A 269
ILE A 379
GLY A 363
GLY A 197
 None
 0.95A 4fakA-4bxwA:
undetectable		 4fakA-4bxwA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxw FACTOR XA

(Pseudonaja
textilis) 		PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		5 LEU A 207
ILE A 269
ILE A 379
GLY A 364
GLY A 197
 None
 0.93A 4fakA-4bxwA:
undetectable		 4fakA-4bxwA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csw CUPIN 4 FAMILY
PROTEIN

(Rhodothermus
marinus) 		PF08007
(Cupin_4) 		5 LEU A  32
ILE A   7
SER A  37
THR A 206
PHE A 207
 None
None
UN9  A1392 ( 4.9A)
None
None
 1.00A 4fakA-4cswA:
undetectable		 4fakA-4cswA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dx3 MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  91
ILE A  89
ILE A  94
GLY A 375
PHE A  87
 None
 0.91A 4fakA-4dx3A:
undetectable		 4fakA-4dx3A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej4 DELTA-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA

(Mus musculus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ILE A 183
GLY A 180
GLY A 178
PHE A 202
MET A 186
 None
 0.97A 4fakA-4ej4A:
undetectable		 4fakA-4ej4A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0j PROBABLE HYDROLYTIC
ENZYME

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		5 LEU A  71
ILE A 139
GLY A 140
GLY A 144
THR A 124
 None
 1.06A 4fakA-4f0jA:
undetectable		 4fakA-4f0jA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3v OXIDOREDUCTASE
DOMAIN PROTEIN

(Kribbella
flavida) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A 147
ILE A 279
GLY A 151
GLY A 154
THR A 204
 None
 1.05A 4fakA-4h3vA:
undetectable		 4fakA-4h3vA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h4f CHYMOTRYPSIN-C

(Homo sapiens) 		PF00089
(Trypsin) 		5 LEU A  53
ILE A 106
ILE A 212
GLY A 196
GLY A  43
 None
 1.03A 4fakA-4h4fA:
undetectable		 4fakA-4h4fA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h4f CHYMOTRYPSIN-C

(Homo sapiens) 		PF00089
(Trypsin) 		5 LEU A  53
ILE A 106
ILE A 212
GLY A 197
GLY A  43
 None
 0.95A 4fakA-4h4fA:
undetectable		 4fakA-4h4fA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnl MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Enterococcus
gallinarum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  35
ILE A 367
GLY A 366
GLY A 364
SER A  91
 None
 1.06A 4fakA-4hnlA:
undetectable		 4fakA-4hnlA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		5 LEU A 322
ILE A 329
GLY A 328
GLY A 327
PHE A 318
 None
 1.05A 4fakA-4i2wA:
undetectable		 4fakA-4i2wA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu9 NITRITE EXTRUSION
PROTEIN 2

(Escherichia
coli) 		no annotation 5 GLY B 362
GLY B 364
PHE B 271
SER B 272
PHE B 356
 None
 0.94A 4fakA-4iu9B:
undetectable		 4fakA-4iu9B:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lur INTERPHOTORECEPTOR
RETINOID-BINDING
PROTEIN(IRBP)

(Danio rerio) 		PF03572
(Peptidase_S41)
PF11918
(Peptidase_S41_N) 		5 LEU A 153
ILE A 156
GLY A 155
GLY A 116
THR A 150
 None
 0.89A 4fakA-4lurA:
undetectable		 4fakA-4lurA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		5 ILE B 124
GLY B 125
GLY B  93
PHE B 209
SER B 208
 None
 0.85A 4fakA-4o9uB:
2.9		 4fakA-4o9uB:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpt LIM DOMAIN KINASE 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 536
ILE A 534
ILE A 539
PHE A 532
SER A 531
 None
 1.01A 4fakA-4tptA:
undetectable		 4fakA-4tptA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysh GLYCINE OXIDASE

(Geobacillus
kaustophilus) 		PF01266
(DAO) 		5 ILE A 206
ILE A  19
GLY A  16
GLY A  11
PHE A 329
 None
None
None
FAD  A 401 (-3.3A)
None
 1.05A 4fakA-4yshA:
undetectable		 4fakA-4yshA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yvd PLEIOTROPIC
REGULATOR 1

(Homo sapiens) 		PF00400
(WD40) 		5 ILE A 406
ILE A 395
GLY A 444
THR A 386
PHE A 387
 None
None
None
UNX  A 607 ( 3.5A)
None
 0.97A 4fakA-4yvdA:
undetectable		 4fakA-4yvdA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxb INSULIN RECEPTOR

(Homo sapiens) 		PF00041
(fn3)
PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 ILE E 336
GLY E 338
GLY E 317
SER E 326
THR E 320
 None
 0.94A 4fakA-4zxbE:
undetectable		 4fakA-4zxbE:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejj UFM1-SPECIFIC
PROTEASE

(Caenorhabditis
elegans) 		PF07910
(Peptidase_C78) 		6 LEU A 106
GLY A  46
GLY A  45
PHE A 121
PHE A  23
MET A  22
 None
 1.08A 4fakA-5ejjA:
undetectable		 4fakA-5ejjA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 LEU A  53
ILE A 106
ILE A 212
GLY A 196
GLY A  43
 None
 1.02A 4fakA-5f8zA:
undetectable		 4fakA-5f8zA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 LEU A  53
ILE A 106
ILE A 212
GLY A 197
GLY A  43
 None
 0.93A 4fakA-5f8zA:
undetectable		 4fakA-5f8zA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fya PATATIN-LIKE
PROTEIN, PLPD

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		5 LEU A  37
ILE A 232
ILE A  40
GLY A  41
GLY A 297
 None
 1.03A 4fakA-5fyaA:
undetectable		 4fakA-5fyaA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvt PLASMA KALLIKREIN

(Mus musculus) 		no annotation 5 LEU A  53
ILE A 106
ILE A 212
GLY A 197
GLY A  43
 None
 0.95A 4fakA-5gvtA:
undetectable		 4fakA-5gvtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 402
ILE A 400
ILE A 405
PHE A 398
SER A 397
 None
 0.97A 4fakA-5ko1A:
undetectable		 4fakA-5ko1A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 ILE E 336
GLY E 338
GLY E 317
SER E 326
THR E 320
 None
 0.98A 4fakA-5kqvE:
undetectable		 4fakA-5kqvE:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		no annotation 5 LEU C 352
ILE C 384
GLY C 386
PHE C 354
THR C 422
 None
 1.06A 4fakA-5o4gC:
undetectable		 4fakA-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila) 		no annotation 5 ILE A 206
GLY A 196
GLY A 200
PHE A 214
SER A 210
 None
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
None
None
 0.88A 4fakA-5o96A:
9.6		 4fakA-5o96A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2

(Homo sapiens) 		no annotation 5 LEU B 198
ILE B 191
GLY B 196
GLY B  72
THR B 126
 None
None
MG  B 704 ( 4.5A)
ATP  B 702 ( 4.5A)
None
 1.05A 4fakA-5ofbB:
undetectable		 4fakA-5ofbB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujz SCFV

(Homo sapiens) 		PF07686
(V-set) 		5 ILE G 156
GLY G 232
GLY G 231
THR G 153
PHE G 152
 None
 0.89A 4fakA-5ujzG:
undetectable		 4fakA-5ujzG:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		5 ILE B 124
GLY B 125
GLY B  93
PHE B 209
SER B 208
 None
 0.94A 4fakA-5uniB:
1.8		 4fakA-5uniB:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		no annotation 5 LEU G 261
ILE G 449
GLY G 451
PHE G 376
SER G 375
 NAG  G 627 ( 4.8A)
None
None
None
None
 0.94A 4fakA-5wduG:
undetectable		 4fakA-5wduG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrj PROTEIN-TYROSINE
SULFOTRANSFERASE 1

(Homo sapiens) 		PF13469
(Sulfotransfer_3) 		5 LEU A 180
ILE A  74
GLY A  75
GLY A  76
MET A  85
 None
 0.77A 4fakA-5wrjA:
undetectable		 4fakA-5wrjA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN

(Pyrococcus
horikoshii) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		5 LEU A 334
ILE A 336
ILE A 382
GLY A   3
GLY A 348
 None
 0.95A 4fakA-5wu7A:
2.6		 4fakA-5wu7A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		5 LEU A 310
ILE A 354
ILE A 286
GLY A 285
PHE A 282
 None
None
None
TB  A1605 (-4.5A)
None
 0.90A 4fakA-5x7sA:
undetectable		 4fakA-5x7sA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydl PKS

(Streptomyces
sp. CNQ431) 		no annotation 5 LEU A  88
ILE A 346
ILE A 170
GLY A 171
GLY A 175
 None
 1.01A 4fakA-5ydlA:
undetectable		 4fakA-5ydlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 5 LEU A 769
ILE A 712
GLY A 713
THR A 786
PHE A 684
 None
 0.91A 4fakA-5z9sA:
undetectable		 4fakA-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6an5 ABC TRANSPORTER

(Aquifex
aeolicus) 		no annotation 5 LEU A  90
ILE A 154
GLY A  93
PHE A 152
SER A 153
 None
 1.07A 4fakA-6an5A:
undetectable		 4fakA-6an5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))

(Escherichia
coli) 		no annotation 5 LEU A 253
ILE A 284
GLY A 234
SER A 248
MET A 262
 None
 0.89A 4fakA-6dkhA:
undetectable		 4fakA-6dkhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2c METHYLGLYOXAL
SYNTHASE

(Bacillus
subtilis) 		no annotation 5 ILE A   6
ILE A  41
GLY A  38
GLY A  35
MET A  15
 None
None
None
GOL  A 201 (-3.3A)
None
 0.98A 4fakA-6f2cA:
undetectable		 4fakA-6f2cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2c METHYLGLYOXAL
SYNTHASE

(Bacillus
subtilis) 		no annotation 5 LEU A   5
ILE A  41
GLY A  38
GLY A  35
MET A  15
 None
None
None
GOL  A 201 (-3.3A)
None
 0.82A 4fakA-6f2cA:
undetectable		 4fakA-6f2cA:
undetectable