SIMILAR PATTERNS OF AMINO ACIDS FOR 4F93_B_SANB3004

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)

(Thermotoga
maritima) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 GLU A  27
GLU A 195
GLY A 182
SER A 181
 None
 0.86A 4f93B-1c3cA:
0.0		 4f93B-1c3cA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLU A 360
GLN A 366
GLY A 365
SER A 364
 ZN  A 408 (-2.8A)
None
None
None
 0.89A 4f93B-1d1tA:
2.0		 4f93B-1d1tA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1djs PROTEIN (FIBROBLAST
GROWTH FACTOR
RECEPTOR 2)

(Homo sapiens) 		PF07679
(I-set) 		4 TRP A 214
ASN A 235
GLY A 238
SER A 239
 None
 0.87A 4f93B-1djsA:
5.1		 4f93B-1djsA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dt2 EXFOLIATIVE TOXIN B

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		4 GLU A 106
GLN A 111
GLY A 110
SER A 107
 None
 0.99A 4f93B-1dt2A:
undetectable		 4f93B-1dt2A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3y DIADENOSINE
5',5'''-P1,P4-TETRAP
HOSPHATE HYDROLASE

(Lupinus
angustifolius) 		PF00293
(NUDIX) 		4 TRP A 134
GLU A 118
GLN A 115
GLY A 114
 None
 0.98A 4f93B-1f3yA:
undetectable		 4f93B-1f3yA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fq9 FIBROBLAST GROWTH
FACTOR RECEPTOR 1

(Homo sapiens) 		PF07679
(I-set) 		4 TRP C 213
ASN C 234
GLY C 237
SER C 238
 None
 0.88A 4f93B-1fq9C:
4.9		 4f93B-1fq9C:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 TRP A 541
ASN A 480
GLN A 412
GLY A 457
 GOL  A1823 (-4.9A)
None
None
None
 1.00A 4f93B-1kb0A:
undetectable		 4f93B-1kb0A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1klq MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2A

(Homo sapiens) 		PF02301
(HORMA) 		4 GLU A 170
GLN A 175
GLY A 173
SER A 172
 None
 0.96A 4f93B-1klqA:
undetectable		 4f93B-1klqA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np7 DNA PHOTOLYASE

(Synechocystis
sp. PCC 6803) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 GLU A 328
GLN A 334
GLY A 333
SER A 332
 None
 0.72A 4f93B-1np7A:
0.0		 4f93B-1np7A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nun FIBROBLAST GROWTH
FACTOR RECEPTOR 2
ISOFORM 2

(Homo sapiens) 		PF07679
(I-set) 		4 TRP B 214
ASN B 235
GLY B 238
SER B 239
 None
 0.82A 4f93B-1nunB:
5.1		 4f93B-1nunB:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)

(Pseudomonas sp.
CF600) 		PF00682
(HMGL-like)
PF01118
(Semialdhyde_dh)
PF07836
(DmpG_comm)
PF09290
(AcetDehyd-dimer) 		4 GLU B 154
GLU B 177
GLY A  94
SER A  95
 None
 1.02A 4f93B-1nvmB:
2.9		 4f93B-1nvmB:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzs SUPEROXIDE DISMUTASE
[CU-ZN]

(Mycobacterium
tuberculosis) 		PF00080
(Sod_Cu) 		4 GLU A  55
ASN A  68
GLY A  67
SER A  58
 None
 0.95A 4f93B-1pzsA:
undetectable		 4f93B-1pzsA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szn ALPHA-GALACTOSIDASE

(Trichoderma
reesei) 		PF16499
(Melibiase_2) 		4 TRP A 221
HIS A 253
GLN A 318
GLY A 317
 None
None
None
NAG  A 701 ( 4.3A)
 0.97A 4f93B-1sznA:
undetectable		 4f93B-1sznA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE

(Clostridium
acetobutylicum) 		PF04029
(2-ph_phosp) 		4 GLU A  70
HIS A 201
ASN A 104
GLY A 146
 3SL  A 300 (-3.4A)
3SL  A 300 (-4.6A)
3SL  A 300 (-4.2A)
MG  A 400 (-4.0A)
 1.01A 4f93B-1vr0A:
undetectable		 4f93B-1vr0A:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		4 HIS A 734
GLU A 735
GLY A 729
SER A 730
 None
 0.80A 4f93B-1xf1A:
6.0		 4f93B-1xf1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLU A 100
GLU A  18
GLY A  22
SER A  21
 None
 0.77A 4f93B-1zwsA:
undetectable		 4f93B-1zwsA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6e RNA POLYMERASE SIGMA
FACTOR RPOD

(Thermus
thermophilus) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4) 		4 GLU F  98
GLU F  87
GLN F  90
GLY F  89
 None
 0.85A 4f93B-2a6eF:
undetectable		 4f93B-2a6eF:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima) 		PF03537
(Glyco_hydro_114) 		4 TRP A 102
GLU A  96
GLN A  94
GLY A  93
 None
UNL  A   1 (-4.2A)
None
None
 0.98A 4f93B-2aamA:
2.8		 4f93B-2aamA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cso PLECKSTRIN

(Homo sapiens) 		PF00610
(DEP) 		4 GLU A 119
GLU A  34
GLY A 115
SER A 114
 None
 1.01A 4f93B-2csoA:
undetectable		 4f93B-2csoA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dku KIAA1556 PROTEIN

(Homo sapiens) 		PF07679
(I-set) 		4 GLU A  71
HIS A  54
GLY A  52
SER A  51
 None
 0.85A 4f93B-2dkuA:
4.8		 4f93B-2dkuA:
4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		4 GLU X 589
GLN X 584
GLY X 583
SER X 582
 None
 0.65A 4f93B-2epkX:
undetectable		 4f93B-2epkX:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 GLU A 147
GLU A 186
GLY A 159
SER A 160
 None
 1.01A 4f93B-2fknA:
4.6		 4f93B-2fknA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		4 GLU A 180
HIS A 106
GLU A 107
GLN A 246
 None
None
BSC  A   2 ( 3.0A)
None
 0.94A 4f93B-2gwcA:
undetectable		 4f93B-2gwcA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		4 HIS A 106
GLU A 165
GLY A 168
SER A 167
 None
MG  A   1 (-2.7A)
None
None
 0.88A 4f93B-2gwcA:
undetectable		 4f93B-2gwcA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		4 TRP A 160
GLU A 222
GLN A 294
SER A 290
 None
 0.95A 4f93B-2hzkA:
undetectable		 4f93B-2hzkA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilu ALDEHYDE
DEHYDROGENASE A

(Escherichia
coli) 		PF00171
(Aldedh) 		4 GLU A 104
GLN A 283
GLY A 282
SER A 281
 None
 1.01A 4f93B-2iluA:
undetectable		 4f93B-2iluA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgv TAGATOSE-6-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		4 GLU A 108
ASN A   8
GLN A 105
GLY A 106
 None
 0.99A 4f93B-2jgvA:
undetectable		 4f93B-2jgvA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ASN A 348
GLN A 111
GLY A 110
SER A 109
 None
MGD  A 811 (-2.8A)
None
None
 0.92A 4f93B-2jirA:
undetectable		 4f93B-2jirA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kfs CONSERVED
HYPOTHETICAL
REGULATORY PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 HIS A 130
GLN A  76
GLY A  75
SER A  74
 None
 0.97A 4f93B-2kfsA:
undetectable		 4f93B-2kfsA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 4 GLU A 223
HIS A  97
GLN A  77
GLY A  75
 None
 0.99A 4f93B-2lgzA:
undetectable		 4f93B-2lgzA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2om6 PROBABLE
PHOSPHOSERINE
PHOSPHATASE

(Pyrococcus
horikoshii) 		PF13419
(HAD_2) 		4 GLU A  60
GLU A 153
ASN A 123
GLY A 122
 None
 0.73A 4f93B-2om6A:
undetectable		 4f93B-2om6A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfm ADENYLOSUCCINATE
LYASE

(Bacillus
anthracis) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 GLU A  27
GLU A 197
GLY A 184
SER A 183
 None
 0.82A 4f93B-2pfmA:
undetectable		 4f93B-2pfmA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qi2 CELL DIVISION
PROTEIN PELOTA
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF03463
(eRF1_1)
PF03465
(eRF1_3) 		4 GLU A 290
ASN A 318
GLN A 322
GLY A 321
 None
 0.57A 4f93B-2qi2A:
undetectable		 4f93B-2qi2A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv8 GENERAL SECRETION
PATHWAY PROTEIN H

(Vibrio cholerae) 		PF12019
(GspH) 		4 GLU A  49
GLN A  55
GLY A  54
SER A  53
 None
 0.82A 4f93B-2qv8A:
undetectable		 4f93B-2qv8A:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rik TITIN

(Oryctolagus
cuniculus) 		PF07679
(I-set) 		4 GLU A 169
ASN A 172
GLY A 175
SER A 176
 None
 0.82A 4f93B-2rikA:
4.9		 4f93B-2rikA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2veo LIPASE A

(Moesziomyces
antarcticus) 		PF03583
(LIP) 		4 GLU A 253
ASN A 257
GLN A 261
GLY A 260
 None
 0.87A 4f93B-2veoA:
undetectable		 4f93B-2veoA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp3 VP39

(Vaccinia virus) 		PF01358
(PARP_regulatory) 		4 GLU A  14
HIS A 192
ASN A 194
SER A 212
 None
 0.84A 4f93B-2vp3A:
3.5		 4f93B-2vp3A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN

(Escherichia
coli) 		PF09084
(NMT1) 		4 GLU A 111
GLN A  34
GLY A  36
SER A  37
 None
None
None
GOL  A1333 (-4.6A)
 0.91A 4f93B-2x26A:
undetectable		 4f93B-2x26A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x75 ADENYLOSUCCINATE
LYASE

(Staphylococcus
aureus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 GLU A  27
GLU A 195
GLY A 182
SER A 181
 None
 0.94A 4f93B-2x75A:
undetectable		 4f93B-2x75A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au0 CLUMPING FACTOR B

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		4 ASN A 388
GLN A 387
GLY A 386
SER A 385
 None
 0.73A 4f93B-3au0A:
5.4		 4f93B-3au0A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b43 TITIN

(Oryctolagus
cuniculus) 		PF07679
(I-set) 		4 GLU A 361
ASN A 364
GLY A 367
SER A 368
 None
 0.90A 4f93B-3b43A:
4.2		 4f93B-3b43A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 GLU A 235
ASN A 188
GLY A 190
SER A 191
 None
None
CL  A   7 ( 3.8A)
None
 0.86A 4f93B-3bgaA:
7.8		 4f93B-3bgaA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25

(Homo sapiens) 		PF05871
(ESCRT-II) 		4 ASN C 121
GLN C 120
GLY C 119
SER C 118
 None
 0.96A 4f93B-3cuqC:
3.7		 4f93B-3cuqC:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 GLU A 211
ASN A 164
GLY A 166
SER A 167
 None
 0.96A 4f93B-3decA:
8.1		 4f93B-3decA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0j DNA POLYMERASE
SUBUNIT DELTA-2

(Homo sapiens) 		PF04042
(DNA_pol_E_B) 		4 ASN A 348
GLN A 347
GLY A 346
SER A 345
 None
 0.70A 4f93B-3e0jA:
undetectable		 4f93B-3e0jA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		4 GLU A1136
ASN A1139
GLN A 739
GLY A1142
 None
 0.99A 4f93B-3egwA:
2.1		 4f93B-3egwA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7o SERINE PROTEASE

(Purpureocillium
lilacinum) 		PF00082
(Peptidase_S8) 		4 ASN A  66
GLN A  65
GLY A  64
SER A  63
 None
 0.72A 4f93B-3f7oA:
undetectable		 4f93B-3f7oA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 GLU B 680
GLU B 598
GLY B 617
SER B 532
 None
 0.97A 4f93B-3h0gB:
undetectable		 4f93B-3h0gB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbd CLASS IV CHITINASE
CHIA4-PA2

(Picea abies) 		PF00182
(Glyco_hydro_19) 		4 TRP A 191
GLN A 205
GLY A 204
SER A 203
 None
 0.86A 4f93B-3hbdA:
undetectable		 4f93B-3hbdA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 GLU B 761
ASN B  89
GLY B 156
SER B 157
 None
 0.86A 4f93B-3hkzB:
undetectable		 4f93B-3hkzB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1u BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE

(Clostridium
acetobutylicum) 		PF04616
(Glyco_hydro_43) 		4 GLU A 121
GLU A  63
GLY A  65
SER A  64
 EDO  A 406 (-4.6A)
None
None
None
 0.99A 4f93B-3k1uA:
undetectable		 4f93B-3k1uA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		4 GLU A  69
HIS A  66
GLY A 185
SER A  65
 None
ZN  A 355 (-3.7A)
None
None
 1.01A 4f93B-3kl9A:
undetectable		 4f93B-3kl9A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4t APH(2'')-ID

(Enterococcus
casseliflavus) 		PF01636
(APH) 		4 GLU A  60
GLU A  38
GLY A  29
SER A  28
 None
 0.95A 4f93B-3n4tA:
undetectable		 4f93B-3n4tA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odj RHOMBOID PROTEASE
GLPG

(Haemophilus
influenzae) 		PF01694
(Rhomboid) 		4 ASN A 105
GLN A 104
GLY A 109
SER A 108
 None
 0.91A 4f93B-3odjA:
undetectable		 4f93B-3odjA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdf 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE

(Mycobacterium
marinum) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		4 HIS A 115
GLU A 117
GLN A 198
GLY A 235
 None
ZN  A 266 ( 3.1A)
None
None
 0.93A 4f93B-3qdfA:
2.1		 4f93B-3qdfA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo6 PROTEASE DO-LIKE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 GLU A 414
GLU A 418
ASN A 392
GLY A 393
 None
 0.92A 4f93B-3qo6A:
undetectable		 4f93B-3qo6A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo6 PROTEASE DO-LIKE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 GLU A 414
GLU A 418
ASN A 392
SER A 390
 None
 0.95A 4f93B-3qo6A:
undetectable		 4f93B-3qo6A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxm TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Thermotoga
maritima) 		PF07729
(FCD) 		4 GLU A 191
GLU A 179
GLY A 184
SER A 183
 None
 0.92A 4f93B-3sxmA:
undetectable		 4f93B-3sxmA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3szb ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		4 GLU A  62
GLN A 241
GLY A 240
SER A 239
 None
 0.99A 4f93B-3szbA:
3.6		 4f93B-3szbA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zw5 GLYOXALASE
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00903
(Glyoxalase) 		4 GLU A  96
GLU A 141
ASN A 144
SER A 129
 None
SO4  A1146 ( 4.9A)
None
None
 0.96A 4f93B-3zw5A:
undetectable		 4f93B-3zw5A:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bok ALPHA-1,6-MANNANASE

(Bacillus
circulans) 		PF03663
(Glyco_hydro_76) 		4 TRP A 128
ASN A 305
GLY A 250
SER A 251
 None
 0.78A 4f93B-4bokA:
undetectable		 4f93B-4bokA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxj AMPDH3

(Pseudomonas
aeruginosa) 		PF01510
(Amidase_2) 		4 GLU A 165
GLU A 117
ASN A 122
GLN A  65
 None
 0.88A 4f93B-4bxjA:
undetectable		 4f93B-4bxjA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eei ADENYLOSUCCINATE
LYASE

(Francisella
tularensis) 		PF00206
(Lyase_1) 		4 GLU A  27
GLU A 195
GLY A 182
SER A 181
 None
 0.95A 4f93B-4eeiA:
undetectable		 4f93B-4eeiA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f15 FAB FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU B  88
GLU B  81
GLY B  15
SER B  16
 None
 0.92A 4f93B-4f15B:
4.8		 4f93B-4f15B:
8.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		8 GLU B1097
TRP B1222
HIS B1236
GLU B1237
ASN B1531
GLN B1707
GLY B1708
SER B1709
 SAN  B2201 (-3.1A)
None
SAN  B2201 (-3.4A)
None
SAN  B2201 (-3.3A)
SAN  B2201 (-3.6A)
SAN  B2201 (-3.6A)
SAN  B2201 (-3.7A)
 0.27A 4f93B-4f92B:
56.1		 4f93B-4f92B:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdj NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 GLU A 256
GLN A 258
GLY A 235
SER A 236
 None
NAG  A 505 (-3.4A)
None
None
 0.91A 4f93B-4gdjA:
undetectable		 4f93B-4gdjA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0o ACETATE KINASE

(Entamoeba
histolytica) 		PF00871
(Acetate_kinase) 		4 GLU A 378
HIS A 198
GLY A 203
SER A 204
 None
 0.98A 4f93B-4h0oA:
undetectable		 4f93B-4h0oA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga) 		no annotation 4 GLU B 292
GLN B 288
GLY B 287
SER B 284
 None
 0.90A 4f93B-4iglB:
undetectable		 4f93B-4iglB:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN

(Helicobacter
pylori) 		PF01497
(Peripla_BP_2) 		4 GLU A 241
GLU A 194
GLY A 204
SER A 203
 None
 0.95A 4f93B-4ls3A:
undetectable		 4f93B-4ls3A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE

(Mycolicibacterium
smegmatis) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		4 HIS A 130
GLU A 132
GLN A 213
GLY A 250
 None
NA  A 301 (-4.0A)
None
None
 1.01A 4f93B-4pfzA:
undetectable		 4f93B-4pfzA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 GLU B 763
ASN B  96
GLY B 163
SER B 164
 None
 1.02A 4f93B-4qiwB:
undetectable		 4f93B-4qiwB:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7s TETRATRICOPEPTIDE
REPEAT PROTEIN

(Parabacteroides
merdae) 		PF13432
(TPR_16) 		4 GLU A 105
GLN A  69
GLY A  66
SER A  81
 None
 0.99A 4f93B-4r7sA:
undetectable		 4f93B-4r7sA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7m LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1

(Homo sapiens) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 ASN A 676
GLN A 675
GLY A 679
SER A 680
 None
 0.84A 4f93B-4u7mA:
undetectable		 4f93B-4u7mA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLU A  40
ASN A 363
GLY A  45
SER A  44
 None
 0.95A 4f93B-4wkyA:
1.8		 4f93B-4wkyA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyr ACETYL-COA
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLU A 188
GLN A 194
GLY A 193
SER A 192
 None
 0.91A 4f93B-4wyrA:
undetectable		 4f93B-4wyrA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN

(Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLU A 237
GLN A 244
GLY A 243
SER A 240
 None
 0.96A 4f93B-4xvxA:
undetectable		 4f93B-4xvxA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjg ALPHA-2-MACROGLOBULI
N

(Escherichia
coli) 		PF11974
(MG1) 		4 GLU A 116
HIS A 128
GLN A  76
GLY A  79
 None
 0.94A 4f93B-4zjgA:
undetectable		 4f93B-4zjgA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjs DESIGNED INFLUENZA
HEMAGGLUTININ STEM
#4454, HA2

(synthetic
construct) 		PF00509
(Hemagglutinin) 		4 ASN D  28
GLN D  27
GLY D  31
SER D  32
 None
 0.96A 4f93B-5cjsD:
undetectable		 4f93B-5cjsD:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqa BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B

(Homo sapiens) 		PF00439
(Bromodomain) 		4 GLU A1916
GLN A1922
GLY A1921
SER A1920
 None
 0.74A 4f93B-5cqaA:
undetectable		 4f93B-5cqaA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iu9 PROTOCADHERIN-19
ISOFORM 1

(Danio rerio) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 GLU A 176
GLU A 249
ASN A 209
GLY A 299
 CA  A1005 ( 2.4A)
None
CA  A1006 (-3.4A)
None
 0.95A 4f93B-5iu9A:
undetectable		 4f93B-5iu9A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5p DNA TOPOISOMERASE 4
SUBUNIT B

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 GLU A  55
GLU A 334
GLN A 110
GLY A 111
 ANP  A 501 (-3.2A)
None
None
None
 0.93A 4f93B-5j5pA:
undetectable		 4f93B-5j5pA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6b ALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		4 GLU A 101
GLN A 283
GLY A 282
SER A 281
 None
 1.02A 4f93B-5j6bA:
undetectable		 4f93B-5j6bA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kis RHS2

(Yersinia
entomophaga) 		no annotation 4 GLU B 292
GLN B 288
GLY B 287
SER B 284
 None
 0.92A 4f93B-5kisB:
undetectable		 4f93B-5kisB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE

(Mus musculus) 		PF01593
(Amino_oxidase) 		4 GLU A 380
GLU A 184
GLY A 189
SER A 188
 None
 1.00A 4f93B-5laeA:
undetectable		 4f93B-5laeA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m77 ALPHA-1,6-MANNANASE

(Bacillus
circulans) 		PF03422
(CBM_6)
PF03663
(Glyco_hydro_76) 		4 TRP A 128
ASN A 305
GLY A 250
SER A 251
 None
None
EDO  A 605 (-3.5A)
None
 0.74A 4f93B-5m77A:
undetectable		 4f93B-5m77A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Francisella
tularensis) 		no annotation 4 GLU A1175
GLU A1167
GLY A1148
SER A1149
 None
 1.01A 4f93B-5ng6A:
undetectable		 4f93B-5ng6A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npr UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110 KDA
SUBUNIT

(Homo sapiens) 		no annotation 4 GLU A 778
ASN A 796
GLN A 784
GLY A 783
 None
 0.78A 4f93B-5nprA:
undetectable		 4f93B-5nprA:
3.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3

(Homo sapiens) 		PF02469
(Fasciclin) 		4 GLU A 248
ASN A 266
GLY A 264
SER A 263
 None
 0.92A 4f93B-5nv6A:
undetectable		 4f93B-5nv6A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pfr BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B

(Homo sapiens) 		PF00439
(Bromodomain) 		4 GLU A1916
GLN A1922
GLY A1921
SER A1920
 None
 0.72A 4f93B-5pfrA:
undetectable		 4f93B-5pfrA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 4 GLU B 278
GLN B 284
GLY B 283
SER B 282
 None
 1.01A 4f93B-5swiB:
undetectable		 4f93B-5swiB:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4r VRC 315 53-1A09 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 GLU A  81
GLU A  23
GLY A   8
SER A   7
 None
 1.01A 4f93B-5u4rA:
undetectable		 4f93B-5u4rA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucd NAD(P)-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		4 GLU A 300
GLN A 311
GLY A 309
SER A 320
 None
 0.98A 4f93B-5ucdA:
undetectable		 4f93B-5ucdA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue0 CT622 PROTEIN

(Chlamydia
trachomatis) 		no annotation 4 GLU A 376
GLN A 369
GLY A 370
SER A 373
 None
 0.88A 4f93B-5ue0A:
undetectable		 4f93B-5ue0A:
4.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'

(Mycobacterium
tuberculosis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 GLU D 993
HIS D1153
GLY D 571
SER D 570
 None
 0.91A 4f93B-5uheD:
undetectable		 4f93B-5uheD:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE

(Citrus sinensis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 GLU A 151
GLU A 165
GLY A 169
SER A 168
 None
 1.01A 4f93B-5uv2A:
undetectable		 4f93B-5uv2A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8e BACILLUS CEREUS
PATB1

(Bacillus cereus) 		no annotation 4 GLU A 263
TRP A 100
ASN A 204
GLY A 207
 None
 0.99A 4f93B-5v8eA:
undetectable		 4f93B-5v8eA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
LARGE SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 4 HIS C 213
GLU C 211
ASN C 207
GLY C 261
 None
None
None
MCN  C 802 (-3.4A)
 0.96A 4f93B-5y6qC:
undetectable		 4f93B-5y6qC:
4.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c62 BIURET HYDROLASE

(Pseudomonas sp.
ADP) 		no annotation 4 GLU A  23
GLU A   8
GLY A  13
SER A  12
 None
 0.77A 4f93B-6c62A:
undetectable		 4f93B-6c62A:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 4 GLU A 604
ASN A 596
GLY A 598
SER A 601
 None
 1.01A 4f93B-6f2tA:
undetectable		 4f93B-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d RIBONUCLEOPROTEIN
P18, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 4 GLU J 108
GLN J 114
GLY J 113
SER J 112
 None
 0.74A 4f93B-6f5dJ:
undetectable		 4f93B-6f5dJ:
3.83