SIMILAR PATTERNS OF AMINO ACIDS FOR 4F92_B_SANB2201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE

(Streptococcus
mutans) 		PF01063
(Aminotran_4) 		5 GLU A 219
TYR A 209
ASN A 188
GLY A 181
SER A 242
 None
 1.14A 4f92B-4dqnA:
0.0		 4f92B-4dqnA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP

(Pseudomonas
putida) 		PF03480
(DctP) 		5 GLU A  71
ASN A 173
GLN A 171
GLY A  91
SER A  89
 BDP  A 401 (-2.8A)
None
BDP  A 401 (-3.7A)
None
BDP  A 401 (-4.9A)
 1.47A 4f92B-4xfeA:
0.0		 4f92B-4xfeA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo sapiens) 		PF12851
(Tet_JBP) 		5 TYR A1345
ASN A1347
GLN A1348
GLY A1391
SER A1392
 None
 1.25A 4f92B-5deuA:
0.0		 4f92B-5deuA:
13.98