SIMILAR PATTERNS OF AMINO ACIDS FOR 4F8H_E_RKEE401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a7j PHOSPHORIBULOKINASE

(Rhodobacter
sphaeroides) 		PF00485
(PRK) 		4 VAL A 154
PHE A  25
LEU A 276
ASP A 269
 None
 0.94A 4f8hA-1a7jA:
undetectable
4f8hE-1a7jA:
undetectable		 4f8hA-1a7jA:
23.08
4f8hE-1a7jA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjb PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)

(Plasmodium
falciparum) 		PF00156
(Pribosyltran) 		4 VAL A 168
PHE A 184
LEU A 153
ASP A 187
 None
 1.10A 4f8hA-1cjbA:
undetectable
4f8hE-1cjbA:
undetectable		 4f8hA-1cjbA:
20.19
4f8hE-1cjbA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlm CATECHOL
1,2-DIOXYGENASE

(Acinetobacter
sp. ADP1) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 LEU A 237
ASN A  99
ASP A  89
ASP A  92
 None
 1.03A 4f8hA-1dlmA:
0.0
4f8hE-1dlmA:
0.0		 4f8hA-1dlmA:
21.45
4f8hE-1dlmA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js4 ENDO/EXOCELLULASE E4

(Thermobifida
fusca) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		4 VAL A 365
ASN A 423
ASP A 416
ASP A 415
 None
 0.84A 4f8hA-1js4A:
0.3
4f8hE-1js4A:
0.4		 4f8hA-1js4A:
20.91
4f8hE-1js4A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 VAL A 667
PHE A 654
ASN A 608
ASP A 674
 None
 1.08A 4f8hA-1qf7A:
0.3
4f8hE-1qf7A:
0.3		 4f8hA-1qf7A:
19.46
4f8hE-1qf7A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t2q FAB NNA7 LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE H  64
LEU H  49
TYR H  94
ASP H  89
 None
 0.84A 4f8hA-1t2qH:
1.1
4f8hE-1t2qH:
1.2		 4f8hA-1t2qH:
18.18
4f8hE-1t2qH:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uiy ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		4 VAL A   4
LEU A  31
ASP A  36
ASP A  37
 None
 0.92A 4f8hA-1uiyA:
undetectable
4f8hE-1uiyA:
undetectable		 4f8hA-1uiyA:
21.45
4f8hE-1uiyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v32 HYPOTHETICAL PROTEIN
RAFL09-47-K03

(Arabidopsis
thaliana) 		PF02201
(SWIB) 		4 VAL A  82
LEU A  20
TYR A  90
ASP A  39
 None
 1.08A 4f8hA-1v32A:
undetectable
4f8hE-1v32A:
undetectable		 4f8hA-1v32A:
15.14
4f8hE-1v32A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xe4 FEMX

(Weissella
viridescens) 		PF02388
(FemAB) 		4 VAL A 111
LEU A 121
ASP A  83
ASP A  80
 None
 0.98A 4f8hA-1xe4A:
undetectable
4f8hE-1xe4A:
undetectable		 4f8hA-1xe4A:
21.27
4f8hE-1xe4A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi9 PUTATIVE
TRANSAMINASE

(Pyrococcus
furiosus) 		PF00155
(Aminotran_1_2) 		4 VAL A 238
LEU A 287
TYR A 248
ASN A 233
 None
 1.09A 4f8hA-1xi9A:
undetectable
4f8hE-1xi9A:
undetectable		 4f8hA-1xi9A:
23.26
4f8hE-1xi9A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT
D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer) 		4 LEU B 163
ASN B 162
ASP A 269
ASP B 138
 None
 1.09A 4f8hA-1xrsB:
undetectable
4f8hE-1xrsB:
undetectable		 4f8hA-1xrsB:
21.02
4f8hE-1xrsB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y89 DEVB PROTEIN

(Vibrio cholerae) 		PF01182
(Glucosamine_iso) 		4 PHE A   7
LYS A   5
ASP A  19
ASP A  20
 None
None
None
PE5  A 242 (-3.6A)
 0.98A 4f8hA-1y89A:
undetectable
4f8hE-1y89A:
undetectable		 4f8hA-1y89A:
20.32
4f8hE-1y89A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys7 TRANSCRIPTIONAL
REGULATORY PROTEIN
PRRA

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 VAL A  19
PHE A 110
LEU A 115
ASP A  58
 None
None
None
MG  A1002 (-2.7A)
 0.97A 4f8hA-1ys7A:
undetectable
4f8hE-1ys7A:
undetectable		 4f8hA-1ys7A:
26.11
4f8hE-1ys7A:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2

(Archaeoglobus
fulgidus) 		PF02552
(CO_dh) 		4 VAL A  28
PHE A  57
LEU A 167
TYR A 163
 None
 1.06A 4f8hA-1ytlA:
undetectable
4f8hE-1ytlA:
undetectable		 4f8hA-1ytlA:
20.06
4f8hE-1ytlA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1

(Medicago
truncatula) 		PF00201
(UDPGT) 		4 VAL A 183
PHE A 193
ASN A 186
ASP A 170
 None
 1.05A 4f8hA-2acvA:
undetectable
4f8hE-2acvA:
undetectable		 4f8hA-2acvA:
23.80
4f8hE-2acvA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bc0 NADH OXIDASE

(Streptococcus
pyogenes) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 173
PHE A 221
LEU A 219
ASP A 206
 None
 0.93A 4f8hA-2bc0A:
undetectable
4f8hE-2bc0A:
undetectable		 4f8hA-2bc0A:
21.05
4f8hE-2bc0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0g WINDBEUTEL PROTEIN

(Drosophila
melanogaster) 		PF07749
(ERp29)
PF07912
(ERp29_N) 		4 VAL A1039
PHE A1049
LEU A1094
ASP A1029
 None
 0.87A 4f8hA-2c0gA:
3.3
4f8hE-2c0gA:
3.3		 4f8hA-2c0gA:
22.02
4f8hE-2c0gA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cve HYPOTHETICAL PROTEIN
TTHA1053

(Thermus
thermophilus) 		PF01205
(UPF0029)
PF09186
(DUF1949) 		4 VAL A  10
PHE A  36
LEU A  89
LYS A   8
 None
 1.06A 4f8hA-2cveA:
undetectable
4f8hE-2cveA:
undetectable		 4f8hA-2cveA:
21.47
4f8hE-2cveA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyg BETA-1, 3-GLUCANANSE

(Musa acuminata) 		PF00332
(Glyco_hydro_17) 		4 VAL A 260
PHE A 175
LEU A 183
ASP A 160
 None
 1.09A 4f8hA-2cygA:
undetectable
4f8hE-2cygA:
undetectable		 4f8hA-2cygA:
21.89
4f8hE-2cygA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d40 PUTATIVE GENTISATE
1,2-DIOXYGENASE

(Escherichia
coli) 		PF07883
(Cupin_2) 		4 LEU A 192
TYR A 191
ASN A 214
ASP A 135
 None
 1.08A 4f8hA-2d40A:
undetectable
4f8hE-2d40A:
undetectable		 4f8hA-2d40A:
21.54
4f8hE-2d40A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6e 5'-NUCLEOTIDASE SURE

(Thermus
thermophilus) 		PF01975
(SurE) 		4 VAL A  31
LEU A  19
ASN A   7
ASP A   9
 None
 1.07A 4f8hA-2e6eA:
undetectable
4f8hE-2e6eA:
undetectable		 4f8hA-2e6eA:
22.29
4f8hE-2e6eA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		4 VAL A 316
LEU A 296
ASP A 379
ASP A 312
 None
None
PO4  A 900 (-3.1A)
NA  A 997 ( 4.9A)
 0.70A 4f8hA-2f6dA:
undetectable
4f8hE-2f6dA:
undetectable		 4f8hA-2f6dA:
20.99
4f8hE-2f6dA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		4 VAL A 172
PHE A 102
LEU A 205
ASP A 187
 None
 0.99A 4f8hA-2ffhA:
undetectable
4f8hE-2ffhA:
undetectable		 4f8hA-2ffhA:
22.40
4f8hE-2ffhA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1

(Saccharomyces
cerevisiae) 		PF03095
(PTPA) 		4 VAL A 239
PHE A 263
LEU A 270
TYR A 212
 None
 1.02A 4f8hA-2ixoA:
undetectable
4f8hE-2ixoA:
undetectable		 4f8hA-2ixoA:
21.20
4f8hE-2ixoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbw 2,6-DIHYDROXY-PSEUDO
-OXYNICOTINE
HYDROLASE

(Paenarthrobacter
nicotinovorans) 		PF06500
(DUF1100) 		4 VAL A 196
LEU A 144
TYR A 189
ASP A 172
 None
 1.08A 4f8hA-2jbwA:
4.1
4f8hE-2jbwA:
3.0		 4f8hA-2jbwA:
24.38
4f8hE-2jbwA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE

(Paramecium
bursaria
Chlorella virus
1) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 VAL A  41
LEU A 217
TYR A 187
ASP A 212
 None
 1.05A 4f8hA-2nv9A:
undetectable
4f8hE-2nv9A:
undetectable		 4f8hA-2nv9A:
22.83
4f8hE-2nv9A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfk 6-PHOSPHOFRUCTOKINAS
E ISOZYME I

(Escherichia
coli) 		PF00365
(PFK) 		4 VAL A  24
PHE A  67
LEU A  68
ASP A  53
 None
 1.06A 4f8hA-2pfkA:
undetectable
4f8hE-2pfkA:
undetectable		 4f8hA-2pfkA:
21.64
4f8hE-2pfkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjp CYTOCHROME C1

(Rhodobacter
sphaeroides) 		PF02167
(Cytochrom_C1) 		4 VAL B  45
PHE B 214
LEU B  29
TYR B  66
 None
 0.94A 4f8hA-2qjpB:
undetectable
4f8hE-2qjpB:
undetectable		 4f8hA-2qjpB:
21.82
4f8hE-2qjpB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		4 VAL A 365
ASN A 422
ASP A 415
ASP A 414
 None
 0.86A 4f8hA-2xfgA:
undetectable
4f8hE-2xfgA:
undetectable		 4f8hA-2xfgA:
21.75
4f8hE-2xfgA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yiu CYTOCHROME C1, HEME
PROTEIN

(Paracoccus
denitrificans) 		PF02167
(Cytochrom_C1) 		4 VAL B  91
PHE B 239
LEU B  75
TYR B 112
 None
 0.93A 4f8hA-2yiuB:
undetectable
4f8hE-2yiuB:
undetectable		 4f8hA-2yiuB:
20.35
4f8hE-2yiuB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al9 PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 LEU A 126
TYR A  63
ASP A 143
ASP A 144
 None
 0.94A 4f8hA-3al9A:
undetectable
4f8hE-3al9A:
undetectable		 4f8hA-3al9A:
19.27
4f8hE-3al9A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 VAL A   2
PHE A  16
LEU A  20
ASP A 326
 None
 1.02A 4f8hA-3cinA:
undetectable
4f8hE-3cinA:
undetectable		 4f8hA-3cinA:
21.45
4f8hE-3cinA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 224
LEU A 212
TYR A 183
ASP A 207
 None
 0.80A 4f8hA-3dfhA:
undetectable
4f8hE-3dfhA:
undetectable		 4f8hA-3dfhA:
21.67
4f8hE-3dfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpu RAB FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF08477
(Roc)
PF16095
(COR) 		4 VAL A 929
LEU A 908
TYR A 904
ASP A 934
 None
 1.05A 4f8hA-3dpuA:
undetectable
4f8hE-3dpuA:
undetectable		 4f8hA-3dpuA:
21.00
4f8hE-3dpuA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19

(Rhodobacter
sphaeroides) 		PF01244
(Peptidase_M19) 		4 VAL A 196
LEU A 227
ASP A 217
ASP A 218
 None
 1.01A 4f8hA-3fdgA:
undetectable
4f8hE-3fdgA:
undetectable		 4f8hA-3fdgA:
21.50
4f8hE-3fdgA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfq UNCHARACTERIZED
PROTEIN LP_2219

(Lactobacillus
plantarum) 		PF10282
(Lactonase) 		4 VAL A 166
PHE A 194
LEU A 192
TYR A 145
 None
 0.95A 4f8hA-3hfqA:
undetectable
4f8hE-3hfqA:
undetectable		 4f8hA-3hfqA:
22.31
4f8hE-3hfqA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j08 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 VAL A 616
LEU A 561
ASP A 654
ASP A 653
 None
 1.05A 4f8hA-3j08A:
2.9
4f8hE-3j08A:
2.9		 4f8hA-3j08A:
20.15
4f8hE-3j08A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y MS30

(Homo sapiens) 		PF00829
(Ribosomal_L21p) 		4 PHE s 176
LEU s 150
TYR s 402
ASP s 363
 None
 1.08A 4f8hA-3j7ys:
undetectable
4f8hE-3j7ys:
undetectable		 4f8hA-3j7ys:
22.39
4f8hE-3j7ys:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbl NLR FAMILY CARD
DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		no annotation 4 VAL K 719
LEU K 746
ASP K 727
ASP K 728
 None
 1.10A 4f8hA-3jblK:
undetectable
4f8hE-3jblK:
undetectable		 4f8hA-3jblK:
16.03
4f8hE-3jblK:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1d 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 VAL A  76
PHE A  80
LEU A  83
ASP A  62
 None
 1.08A 4f8hA-3k1dA:
undetectable
4f8hE-3k1dA:
undetectable		 4f8hA-3k1dA:
18.13
4f8hE-3k1dA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keh GLUCOCEREBROSIDASE

(Homo sapiens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 VAL A  17
PHE A   9
LEU A 354
LYS A   7
 None
 1.09A 4f8hA-3kehA:
undetectable
4f8hE-3kehA:
undetectable		 4f8hA-3kehA:
21.43
4f8hE-3kehA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		4 TYR A  62
ASN A  64
ASP A  65
ASP A  66
 None
 0.83A 4f8hA-3l8aA:
undetectable
4f8hE-3l8aA:
undetectable		 4f8hA-3l8aA:
22.38
4f8hE-3l8aA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS

(Corynebacterium
glutamicum) 		PF00578
(AhpC-TSA) 		4 VAL A  37
LEU A  10
ASP A  13
ASP A 101
 None
 0.94A 4f8hA-3lorA:
undetectable
4f8hE-3lorA:
undetectable		 4f8hA-3lorA:
21.09
4f8hE-3lorA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3og5 OUTER MEMBRANE
PROTEIN ASSEMBLY
COMPLEX, YAET
PROTEIN

(Escherichia
coli) 		PF07244
(POTRA) 		4 VAL A 364
PHE A 395
ASN A 357
ASP A 358
 None
 0.97A 4f8hA-3og5A:
undetectable
4f8hE-3og5A:
undetectable		 4f8hA-3og5A:
18.32
4f8hE-3og5A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		4 VAL B 107
PHE B 196
TYR B 133
ASP B 115
 None
 1.09A 4f8hA-3p8cB:
2.3
4f8hE-3p8cB:
2.2		 4f8hA-3p8cB:
14.75
4f8hE-3p8cB:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9o EXOTOXIN A

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		4 VAL A 211
LEU A 116
ASN A 114
ASP A 132
 None
 1.06A 4f8hA-3q9oA:
undetectable
4f8hE-3q9oA:
undetectable		 4f8hA-3q9oA:
19.18
4f8hE-3q9oA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qn3 ENOLASE

(Campylobacter
jejuni) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 VAL A 240
LEU A 270
ASN A 214
ASP A 160
 None
 0.99A 4f8hA-3qn3A:
undetectable
4f8hE-3qn3A:
undetectable		 4f8hA-3qn3A:
21.04
4f8hE-3qn3A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY

(Alicyclobacillus
acidocaldarius) 		PF13472
(Lipase_GDSL_2) 		4 VAL A  68
LEU A 116
TYR A 112
ASP A  13
 None
None
None
ACT  A 301 (-3.8A)
 1.09A 4f8hA-3rjtA:
undetectable
4f8hE-3rjtA:
undetectable		 4f8hA-3rjtA:
19.88
4f8hE-3rjtA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Staphylococcus
aureus) 		PF03099
(BPL_LplA_LipB)
PF08279
(HTH_11) 		4 PHE A 264
LEU A 155
ASP A 299
ASP A 297
 None
 0.95A 4f8hA-3rkxA:
undetectable
4f8hE-3rkxA:
undetectable		 4f8hA-3rkxA:
21.02
4f8hE-3rkxA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Clostridium
beijerinckii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 224
LEU A 212
TYR A 183
ASP A 207
 None
None
None
MG  A 402 (-3.0A)
 0.95A 4f8hA-3s47A:
undetectable
4f8hE-3s47A:
undetectable		 4f8hA-3s47A:
21.50
4f8hE-3s47A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE

(Mus musculus) 		PF08645
(PNK3P)
PF13671
(AAA_33) 		4 VAL A 213
PHE A 312
LEU A 318
ASP A 266
 None
 1.05A 4f8hA-3u7gA:
undetectable
4f8hE-3u7gA:
undetectable		 4f8hA-3u7gA:
22.79
4f8hE-3u7gA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2

(Escherichia
coli) 		PF00294
(PfkB) 		4 VAL A 144
LEU A 121
LYS A 148
ASP A 116
 None
 1.02A 4f8hA-3uqeA:
undetectable
4f8hE-3uqeA:
undetectable		 4f8hA-3uqeA:
22.38
4f8hE-3uqeA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v6o MONOCLONAL ANTIBODY
9F8 FAB FRAGMENT
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE C  65
LEU C  50
TYR C  95
ASP C  90
 None
 0.91A 4f8hA-3v6oC:
undetectable
4f8hE-3v6oC:
undetectable		 4f8hA-3v6oC:
19.68
4f8hE-3v6oC:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vfg 3F8 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE H  63
LEU H  48
TYR H  90
ASP H  85
 None
 0.95A 4f8hA-3vfgH:
3.5
4f8hE-3vfgH:
undetectable		 4f8hA-3vfgH:
19.50
4f8hE-3vfgH:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vfi THIOREDOXIN

(Silicibacter
phage DSS3phi2) 		PF00085
(Thioredoxin) 		4 VAL A  14
PHE A  25
LEU A  68
ASP A   7
 None
 1.09A 4f8hA-3vfiA:
undetectable
4f8hE-3vfiA:
undetectable		 4f8hA-3vfiA:
17.78
4f8hE-3vfiA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgk CELL DIVISION
PROTEIN FTSZ

(Staphylococcus
aureus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 VAL A 212
PHE A 100
LEU A  14
ASP A 199
 None
 1.02A 4f8hA-3wgkA:
undetectable
4f8hE-3wgkA:
undetectable		 4f8hA-3wgkA:
21.07
4f8hE-3wgkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zkm FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE C  63
LEU C  48
TYR C  93
ASP C  88
 GOL  C1217 (-4.0A)
None
None
GOL  C1217 ( 4.5A)
 0.83A 4f8hA-3zkmC:
3.3
4f8hE-3zkmC:
undetectable		 4f8hA-3zkmC:
21.94
4f8hE-3zkmC:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bji TRANSCRIPTION FACTOR
TAU SUBUNIT SFC1

(Schizosaccharomyces
pombe) 		PF09734
(Tau95) 		4 LEU A 367
TYR A 321
ASP A 310
ASP A 328
 None
 1.09A 4f8hA-4bjiA:
undetectable
4f8hE-4bjiA:
undetectable		 4f8hA-4bjiA:
21.23
4f8hE-4bjiA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		4 VAL A 130
LEU A 220
ASP A 141
ASP A 142
 None
 0.83A 4f8hA-4eq9A:
undetectable
4f8hE-4eq9A:
undetectable		 4f8hA-4eq9A:
20.69
4f8hE-4eq9A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex6 ALNB

(Streptomyces
sp. CM020) 		PF13419
(HAD_2) 		4 VAL A  12
PHE A 215
LEU A  20
ASP A 104
 None
 1.03A 4f8hA-4ex6A:
undetectable
4f8hE-4ex6A:
undetectable		 4f8hA-4ex6A:
23.17
4f8hE-4ex6A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gip FUSION GLYCOPROTEIN
F1
FUSION GLYCOPROTEIN
F2

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		4 LEU A  38
TYR A  40
ASN D 336
ASP D 337
 None
 1.11A 4f8hA-4gipA:
undetectable
4f8hE-4gipA:
undetectable		 4f8hA-4gipA:
16.85
4f8hE-4gipA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1i MALATE DEHYDROGENASE

(Leishmania
major) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A 260
LEU A 164
ASP A 247
ASP A 251
 None
 1.01A 4f8hA-4i1iA:
undetectable
4f8hE-4i1iA:
undetectable		 4f8hA-4i1iA:
24.86
4f8hE-4i1iA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6f PUTATIVE ALCOHOL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 153
PHE A 313
LEU A 316
ASP A  90
 None
 1.02A 4f8hA-4j6fA:
undetectable
4f8hE-4j6fA:
undetectable		 4f8hA-4j6fA:
22.43
4f8hE-4j6fA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 VAL A 422
LEU A 387
ASP A 451
ASP A 448
 None
 1.05A 4f8hA-4jcmA:
undetectable
4f8hE-4jcmA:
undetectable		 4f8hA-4jcmA:
18.21
4f8hE-4jcmA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Cordyceps
militaris) 		PF04909
(Amidohydro_2) 		4 VAL A 299
PHE A 193
LEU A 248
ASP A  10
 None
 0.91A 4f8hA-4lanA:
undetectable
4f8hE-4lanA:
undetectable		 4f8hA-4lanA:
22.47
4f8hE-4lanA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqb THYMIDYLATE KINASE

(Staphylococcus
aureus) 		PF02223
(Thymidylate_kin) 		4 VAL A  88
LEU A  74
TYR A  93
ASP A 126
 None
 1.02A 4f8hA-4mqbA:
undetectable
4f8hE-4mqbA:
undetectable		 4f8hA-4mqbA:
22.01
4f8hE-4mqbA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 PHE A 536
LEU A 524
LYS A 540
ASP A 482
 None
 0.94A 4f8hA-4o1oA:
undetectable
4f8hE-4o1oA:
undetectable		 4f8hA-4o1oA:
18.53
4f8hE-4o1oA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozx ALGINATE LYASE

(Klebsiella
pneumoniae) 		PF08787
(Alginate_lyase2) 		4 VAL A  40
TYR A  60
ASN A  62
ASP A  64
 None
 1.06A 4f8hA-4ozxA:
undetectable
4f8hE-4ozxA:
undetectable		 4f8hA-4ozxA:
24.61
4f8hE-4ozxA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsl FRUCTOSYL PEPTIDE
OXIDASE

(Penicillium
terrenum) 		PF01266
(DAO) 		4 VAL A 260
LEU A 333
TYR A 254
ASN A 140
 None
 0.97A 4f8hA-4rslA:
undetectable
4f8hE-4rslA:
undetectable		 4f8hA-4rslA:
22.22
4f8hE-4rslA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwy ANTIBODY 8ANC131
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE H  63
LEU H  48
TYR H  90
ASP H  85
 None
 0.81A 4f8hA-4rwyH:
undetectable
4f8hE-4rwyH:
undetectable		 4f8hA-4rwyH:
22.12
4f8hE-4rwyH:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s17 GLUTAMINE SYNTHETASE

(Bifidobacterium
adolescentis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 VAL A  92
PHE A  48
LEU A  44
ASP A   9
 None
 1.10A 4f8hA-4s17A:
undetectable
4f8hE-4s17A:
undetectable		 4f8hA-4s17A:
23.05
4f8hE-4s17A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3j PROTEIN STU2

(Saccharomyces
cerevisiae) 		no annotation 4 VAL C 355
LEU C 362
TYR C 369
ASP C 326
 None
 1.07A 4f8hA-4u3jC:
2.5
4f8hE-4u3jC:
2.5		 4f8hA-4u3jC:
21.19
4f8hE-4u3jC:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN

(Gloeobacter
violaceus;
Homo sapiens) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 TYR A  23
ASN A 152
ASP A 153
ASP A 154
 None
 0.62A 4f8hA-4x5tA:
34.3
4f8hE-4x5tA:
34.2		 4f8hA-4x5tA:
71.91
4f8hE-4x5tA:
71.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhu PROTEIN TIMELESS
HOMOLOG

(Homo sapiens) 		no annotation 4 VAL D  47
LEU D  31
ASP D  36
ASP D  37
 None
 0.93A 4f8hA-4xhuD:
undetectable
4f8hE-4xhuD:
undetectable		 4f8hA-4xhuD:
15.08
4f8hE-4xhuD:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czr CADHERIN-RELATED
FAMILY MEMBER 2

(Homo sapiens) 		PF00028
(Cadherin) 		4 VAL A 211
PHE A 157
LEU A 167
ASP A 152
 None
 0.88A 4f8hA-5czrA:
undetectable
4f8hE-5czrA:
undetectable		 4f8hA-5czrA:
23.69
4f8hE-5czrA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19

(Escherichia
coli;
Tetrahymena
thermophila) 		PF13416
(SBP_bac_8) 		4 VAL A 407
PHE A 474
LEU A 507
ASP A 386
 None
None
GOL  A 607 (-4.1A)
None
 1.01A 4f8hA-5dfmA:
undetectable
4f8hE-5dfmA:
undetectable		 4f8hA-5dfmA:
18.22
4f8hE-5dfmA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgq PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN

(Photobacterium
profundum) 		PF00759
(Glyco_hydro_9) 		4 TYR A 156
ASN A 359
ASP A 360
ASP A 361
 None
 0.83A 4f8hA-5dgqA:
undetectable
4f8hE-5dgqA:
undetectable		 4f8hA-5dgqA:
20.72
4f8hE-5dgqA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqp EDTA MONOOXYGENASE

(EDTA-degrading
bacterium BNC1) 		PF00296
(Bac_luciferase) 		4 VAL A 125
LEU A 105
ASP A  74
ASP A  57
 None
 1.06A 4f8hA-5dqpA:
undetectable
4f8hE-5dqpA:
undetectable		 4f8hA-5dqpA:
20.73
4f8hE-5dqpA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		4 VAL A 251
LEU A 299
ASP A 448
ASP A 449
 None
 1.00A 4f8hA-5ek8A:
2.4
4f8hE-5ek8A:
2.5		 4f8hA-5ek8A:
20.26
4f8hE-5ek8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE H  64
LEU H  49
TYR H  94
ASP H  89
 None
 0.92A 4f8hA-5eorH:
undetectable
4f8hE-5eorH:
undetectable		 4f8hA-5eorH:
19.63
4f8hE-5eorH:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1

(Caenorhabditis
elegans;
Homo sapiens) 		PF00090
(TSP_1)
PF10250
(O-FucT) 		4 VAL A 244
LEU A 369
ASP A 262
ASP A 259
 None
 1.09A 4f8hA-5foeA:
undetectable
4f8hE-5foeA:
undetectable		 4f8hA-5foeA:
20.84
4f8hE-5foeA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1k GEM-ASSOCIATED
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 VAL A  36
PHE A  72
LEU A  27
ASP A  95
 None
 0.79A 4f8hA-5h1kA:
undetectable
4f8hE-5h1kA:
undetectable		 4f8hA-5h1kA:
18.78
4f8hE-5h1kA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpz SQUAMOUS CELL
CARCINOMA ANTIGEN
RECOGNIZED BY
T-CELLS 3

(Homo sapiens) 		no annotation 4 LEU A 289
LYS A 296
TYR A 285
ASP A 261
 None
 1.00A 4f8hA-5jpzA:
2.9
4f8hE-5jpzA:
3.6		 4f8hA-5jpzA:
21.06
4f8hE-5jpzA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH

(Escherichia
coli) 		PF00419
(Fimbrial)
PF09160
(FimH_man-bind) 		4 VAL A 274
LEU A 193
TYR A 278
ASP A 162
 None
 1.09A 4f8hA-5jr4A:
undetectable
4f8hE-5jr4A:
undetectable		 4f8hA-5jr4A:
21.73
4f8hE-5jr4A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1

(Rattus
norvegicus) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF13426
(PAS_9) 		4 LEU A  18
TYR A  44
ASN A  46
ASP A  47
 None
 0.77A 4f8hA-5k7lA:
3.3
4f8hE-5k7lA:
3.3		 4f8hA-5k7lA:
16.38
4f8hE-5k7lA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kss 5'-NUCLEOTIDASE SURE

(Xylella
fastidiosa) 		PF01975
(SurE) 		4 VAL A  32
LEU A  19
ASN A   7
ASP A   9
 None
None
None
MN  A 501 (-3.1A)
 1.11A 4f8hA-5kssA:
undetectable
4f8hE-5kssA:
undetectable		 4f8hA-5kssA:
21.92
4f8hE-5kssA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldn ANTIBODY

(Mus musculus) 		no annotation 4 PHE H  62
LEU H  47
TYR H  92
ASP H  87
 None
 0.80A 4f8hA-5ldnH:
undetectable
4f8hE-5ldnH:
undetectable		 4f8hA-5ldnH:
20.19
4f8hE-5ldnH:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mn5 CELL DIVISION
PROTEIN FTSZ

(Staphylococcus
aureus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 VAL A 214
PHE A 100
LEU A  14
ASP A 199
 None
 0.90A 4f8hA-5mn5A:
undetectable
4f8hE-5mn5A:
undetectable		 4f8hA-5mn5A:
21.99
4f8hE-5mn5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngj TAIL TUBE PROTEIN

(Escherichia
virus T5) 		no annotation 4 VAL A 167
PHE A 353
LEU A 351
ASP A  91
 None
 1.10A 4f8hA-5ngjA:
undetectable
4f8hE-5ngjA:
undetectable		 4f8hA-5ngjA:
14.75
4f8hE-5ngjA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmv FAB HEAVY CHAIN

(Mus) 		no annotation 4 PHE H  63
LEU H  48
TYR H  93
ASP H  88
 None
 0.96A 4f8hA-5nmvH:
3.2
4f8hE-5nmvH:
undetectable		 4f8hA-5nmvH:
12.97
4f8hE-5nmvH:
12.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5osb PROTON-GATED ION
CHANNEL,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Gloeobacter
violaceus;
Mus musculus) 		no annotation 4 VAL A  78
PHE A 173
LEU A 175
LYS A 182
 ACT  A 503 ( 4.0A)
None
None
None
 0.28A 4f8hA-5osbA:
34.3
4f8hE-5osbA:
34.2		 4f8hA-5osbA:
70.88
4f8hE-5osbA:
70.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqm CINNAMOYL-COA
REDUCTASE

(Sorghum bicolor) 		PF01370
(Epimerase) 		4 VAL A 229
LEU A 217
TYR A  42
ASP A 249
 None
None
NAP  A 401 (-4.5A)
None
 0.82A 4f8hA-5tqmA:
undetectable
4f8hE-5tqmA:
undetectable		 4f8hA-5tqmA:
22.53
4f8hE-5tqmA:
22.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v6n PROTON-GATED ION
CHANNEL

(Gloeobacter
violaceus) 		no annotation 4 TYR C  23
ASN C 152
ASP C 153
ASP C 154
 None
 0.79A 4f8hA-5v6nC:
36.1
4f8hE-5v6nC:
36.1		 4f8hA-5v6nC:
98.71
4f8hE-5v6nC:
98.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v6n PROTON-GATED ION
CHANNEL

(Gloeobacter
violaceus) 		no annotation 4 VAL C  79
PHE C 174
LEU C 176
LYS C 183
 None
 0.47A 4f8hA-5v6nC:
36.1
4f8hE-5v6nC:
36.1		 4f8hA-5v6nC:
98.71
4f8hE-5v6nC:
98.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Burkholderia
multivorans) 		PF00155
(Aminotran_1_2) 		4 VAL A 153
ASN A 136
ASP A 179
ASP A 133
 None
None
9EV  A 242 ( 3.7A)
None
 1.00A 4f8hA-5vnxA:
undetectable
4f8hE-5vnxA:
undetectable		 4f8hA-5vnxA:
23.36
4f8hE-5vnxA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 VAL A  88
PHE A  64
LEU A  70
ASP A  46
 None
 1.06A 4f8hA-5wy3A:
2.6
4f8hE-5wy3A:
3.8		 4f8hA-5wy3A:
23.56
4f8hE-5wy3A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y88 -

(-) 		no annotation 4 VAL U 682
LEU U 703
TYR U 640
ASP U 707
 None
 0.91A 4f8hA-5y88U:
2.3
4f8hE-5y88U:
2.5		 4f8hA-5y88U:
undetectable
4f8hE-5y88U:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 PHE A2090
LEU A2053
ASP A1984
ASP A1987
 None
 0.76A 4f8hA-6b3rA:
3.0
4f8hE-6b3rA:
3.0		 4f8hA-6b3rA:
16.81
4f8hE-6b3rA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpz PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,MOUSE
PIEZO1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 PHE A2090
LEU A2053
ASP A1984
ASP A1987
 None
 0.98A 4f8hA-6bpzA:
3.0
4f8hE-6bpzA:
3.5		 4f8hA-6bpzA:
13.82
4f8hE-6bpzA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gy8 -

(-) 		no annotation 4 TYR A 159
ASN A 161
ASP A 162
ASP A 163
 None
 1.04A 4f8hA-6gy8A:
4.8
4f8hE-6gy8A:
4.8		 4f8hA-6gy8A:
undetectable
4f8hE-6gy8A:
undetectable