SIMILAR PATTERNS OF AMINO ACIDS FOR 4F84_A_SAMA501_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 13pk | 3-PHOSPHOGLYCERATEKINASE (Trypanosomabrucei) |
PF00162(PGK) | 5 | GLY A 352GLY A 342THR A 353TYR A 325VAL A 326 | NoneADP A 421 (-3.1A)NoneNoneNone | 0.78A | 4f84A-13pkA:2.0 | 4f84A-13pkA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ayy | GLYCOSYLASPARAGINASE (Elizabethkingiameningoseptica) |
PF01112(Asparaginase_2) | 5 | GLY B 214GLY B 188VAL B 218THR B 215VAL B 255 | None | 1.21A | 4f84A-1ayyB:undetectable | 4f84A-1ayyB:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1chd | CHEB METHYLESTERASE (Salmonellaenterica) |
PF01339(CheB_methylest) | 5 | GLY A 282GLY A 166THR A 281MET A 314VAL A 260 | None | 1.23A | 4f84A-1chdA:undetectable | 4f84A-1chdA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cyd | CARBONYL REDUCTASE (Mus musculus) |
PF13561(adh_short_C2) | 5 | GLY A 14GLY A 16VAL A 37THR A 38VAL A 106 | NDP A 245 (-3.0A)NDP A 245 (-3.7A)NoneNDP A 245 (-4.0A)NDP A 245 (-4.2A) | 0.98A | 4f84A-1cydA:6.6 | 4f84A-1cydA:24.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cyg | CYCLODEXTRINGLUCANOTRANSFERASE (Geobacillusstearothermophilus) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG)PF02806(Alpha-amylase_C) | 5 | GLY A 481GLY A 479VAL A 430LEU A 460MET A 340 | None | 1.24A | 4f84A-1cygA:undetectable | 4f84A-1cygA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f2d | 1-AMINOCYCLOPROPANE-1-CARBOXYLATEDEAMINASE (Cyberlindnerasaturnus) |
PF00291(PALP) | 5 | GLY A 172GLY A 208THR A 245LEU A 248TYR A 57 | None | 1.13A | 4f84A-1f2dA:undetectable | 4f84A-1f2dA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g8k | ARSENITE OXIDASE (Alcaligenesfaecalis) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 5 | GLY A 29GLY A 27THR A 20GLN A 424VAL A 85 | NoneF3S A5005 (-3.9A)NoneNoneNone | 1.25A | 4f84A-1g8kA:2.6 | 4f84A-1g8kA:16.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jqe | HISTAMINEN-METHYLTRANSFERASE (Homo sapiens) |
PF13489(Methyltransf_23) | 5 | GLY A 60GLY A 62VAL A 88TYR A 147VAL A 148 | SAH A 400 (-3.3A)SAH A 400 (-3.2A)NoneQUN A 500 ( 3.6A)SAH A 400 ( 4.8A) | 0.67A | 4f84A-1jqeA:13.6 | 4f84A-1jqeA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kph | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPIDSYNTHASE 1 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 5 | GLY A 72GLY A 74THR A 94LEU A 95GLN A 99 | SAH A1900 (-3.1A)SAH A1900 (-3.2A)SAH A1900 (-4.0A)SAH A1900 (-4.4A)SAH A1900 (-2.9A) | 0.42A | 4f84A-1kphA:25.1 | 4f84A-1kphA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kpi | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPIDSYNTHASE 2 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 5 | GLY A 80GLY A 82THR A 102LEU A 103GLN A 107 | SAH A 900 (-3.3A)SAH A 900 (-3.1A)SAH A 900 (-4.0A)SAH A 900 (-4.4A)SAH A 900 (-2.9A) | 0.41A | 4f84A-1kpiA:24.0 | 4f84A-1kpiA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1e | MYCOLIC ACIDSYNTHASE (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 5 | GLY A 72GLY A 74THR A 94LEU A 95GLN A 99 | SAH A 900 (-3.1A)SAH A 900 (-3.4A)SAH A 900 (-4.4A)SAH A 900 (-4.1A)SAH A 900 (-3.1A) | 0.46A | 4f84A-1l1eA:25.4 | 4f84A-1l1eA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mns | MANDELATE RACEMASE (Pseudomonasputida) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 106GLY A 276SER A 49TYR A 50VAL A 35 | None | 1.05A | 4f84A-1mnsA:undetectable | 4f84A-1mnsA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ri3 | MRNA CAPPING ENZYME (Encephalitozooncuniculi) |
PF03291(Pox_MCEL) | 5 | GLY A 72GLY A 74VAL A 93SER A 142TYR A 145 | SAH A 299 (-3.3A)SAH A 299 (-3.5A)NoneSAH A 299 (-3.0A)SAH A 299 (-4.2A) | 0.79A | 4f84A-1ri3A:16.9 | 4f84A-1ri3A:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sgl | TRICHOMAGLIN (Trichosantheslepiniana) |
PF00445(Ribonuclease_T2) | 5 | GLY A 174VAL A 176LEU A 151SER A 197VAL A 195 | None | 1.24A | 4f84A-1sglA:undetectable | 4f84A-1sglA:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tpy | METHOXY MYCOLIC ACIDSYNTHASE 2 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 5 | GLY A 72GLY A 74THR A 94LEU A 95GLN A 99 | SAH A1900 (-3.2A)SAH A1900 (-3.3A)SAH A1900 (-4.1A)SAH A1900 (-4.3A)SAH A1900 (-3.0A) | 0.47A | 4f84A-1tpyA:25.5 | 4f84A-1tpyA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ur4 | GALACTANASE (Bacilluslicheniformis) |
PF07745(Glyco_hydro_53) | 5 | GLY A 314GLY A 311VAL A 307LEU A 248VAL A 228 | None | 0.93A | 4f84A-1ur4A:undetectable | 4f84A-1ur4A:23.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y8c | S-ADENOSYLMETHIONINE-DEPENDENTMETHYLTRANSFERASE (Clostridiumacetobutylicum) |
PF13649(Methyltransf_25) | 5 | GLY A 48VAL A 66LEU A 68SER A 112TYR A 115 | None | 1.03A | 4f84A-1y8cA:16.6 | 4f84A-1y8cA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2avn | UBIQUINONE/MENAQUINONE BIOSYNTHESISMETHYLTRANSFERASE-RELATED PROTEIN (Thermotogamaritima) |
PF08241(Methyltransf_11) | 5 | GLY A 50GLY A 52VAL A 70TYR A 115VAL A 116 | SAI A1300 (-3.5A)SAI A1300 (-3.5A)NoneSAI A1300 (-4.8A)SAI A1300 ( 4.0A) | 1.01A | 4f84A-2avnA:15.2 | 4f84A-2avnA:24.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cun | PHOSPHOGLYCERATEKINASE (Pyrococcushorikoshii) |
PF00162(PGK) | 5 | GLY A 339GLY A 329VAL A 341THR A 340TYR A 312 | None | 1.06A | 4f84A-2cunA:undetectable | 4f84A-2cunA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dy0 | ADENINEPHOSPHORIBOSYLTRANSFERASE (Escherichiacoli) |
PF00156(Pribosyltran) | 5 | GLY A 62GLY A 67VAL A 85THR A 63VAL A 122 | None | 1.21A | 4f84A-2dy0A:3.8 | 4f84A-2dy0A:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2et6 | (3R)-HYDROXYACYL-COADEHYDROGENASE (Candidatropicalis) |
PF00106(adh_short) | 5 | GLY A 15GLY A 17LEU A 40ASN A 74VAL A 121 | None | 1.10A | 4f84A-2et6A:6.7 | 4f84A-2et6A:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fk7 | METHOXY MYCOLIC ACIDSYNTHASE 4 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 5 | GLY A 81GLY A 83THR A 103LEU A 104GLN A 108 | None | 0.55A | 4f84A-2fk7A:24.6 | 4f84A-2fk7A:29.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fm4 | PYRUVATE, PHOSPHATEDIKINASE ([Clostridium]symbiosum) |
PF00391(PEP-utilizers) | 5 | GLY A 470GLY A 450VAL A 448THR A 447LEU A 446 | None | 1.20A | 4f84A-2fm4A:undetectable | 4f84A-2fm4A:17.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fsr | ACETYLTRANSFERASE (Agrobacteriumfabrum) |
PF13302(Acetyltransf_3) | 5 | GLY A 94GLY A 81SER A 129TYR A 130VAL A 131 | None | 1.24A | 4f84A-2fsrA:undetectable | 4f84A-2fsrA:24.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gv8 | MONOOXYGENASE (Schizosaccharomycespombe) |
PF00743(FMO-like)PF13450(NAD_binding_8) | 5 | GLY A 18GLY A 15VAL A 20LEU A 128VAL A 34 | NoneFAD A 500 (-3.4A)NoneNoneNone | 1.11A | 4f84A-2gv8A:undetectable | 4f84A-2gv8A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hgs | PROTEIN (GLUTATHIONESYNTHETASE) (Homo sapiens) |
PF03199(GSH_synthase)PF03917(GSH_synth_ATP) | 5 | GLY A 191GLY A 187LEU A 227TYR A 265VAL A 263 | None | 0.98A | 4f84A-2hgsA:undetectable | 4f84A-2hgsA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2opi | L-FUCULOSE-1-PHOSPHATE ALDOLASE (Bacteroidesthetaiotaomicron) |
PF00596(Aldolase_II) | 5 | HIS A 158GLY A 159LEU A 92SER A 27VAL A 47 | None | 1.18A | 4f84A-2opiA:undetectable | 4f84A-2opiA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oq2 | PHOSPHOADENOSINEPHOSPHOSULFATEREDUCTASE (Saccharomycescerevisiae) |
PF01507(PAPS_reduct) | 5 | GLY A 54GLY A 158VAL A 56THR A 53LEU A 52 | A3P A 999 (-3.1A)A3P A 999 (-3.2A)NoneA3P A 999 ( 4.6A)None | 1.21A | 4f84A-2oq2A:undetectable | 4f84A-2oq2A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qy1 | PECTATE LYASE II (Xanthomonascampestris) |
PF00544(Pec_lyase_C) | 5 | GLY A 24LEU A 351ASN A 124SER A 190TYR A 191 | None | 1.23A | 4f84A-2qy1A:undetectable | 4f84A-2qy1A:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzb | UNCHARACTERIZEDPROTEIN YFEY (Escherichiacoli) |
PF06572(DUF1131) | 5 | GLY A 99GLY A 102VAL A 82ASN A 78SER A 105 | None | 1.20A | 4f84A-2qzbA:undetectable | 4f84A-2qzbA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wyh | ALPHA-MANNOSIDASE (Streptococcuspyogenes) |
PF01074(Glyco_hydro_38)PF07748(Glyco_hydro_38C)PF09261(Alpha-mann_mid) | 5 | GLY A 84GLY A 107THR A 55LEU A 58SER A 117 | None | 1.08A | 4f84A-2wyhA:undetectable | 4f84A-2wyhA:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y77 | 3-DEHYDROQUINATEDEHYDRATASE (Mycobacteriumtuberculosis) |
PF01220(DHquinase_II) | 5 | HIS A 81GLY A 78LEU A 86SER A 115TYR A 116 | CB8 A1144 (-3.8A)CB8 A1144 (-3.3A)NoneNoneNone | 1.23A | 4f84A-2y77A:undetectable | 4f84A-2y77A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yfh | GLUTAMATEDEHYDROGENASE,NAD-SPECIFICGLUTAMATEDEHYDROGENASE,GLUTAMATEDEHYDROGENASE (Escherichiacoli;[Clostridium]symbiosum) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | GLY A 127GLY A 91VAL A 80GLN A 111VAL A 99 | None | 1.18A | 4f84A-2yfhA:4.3 | 4f84A-2yfhA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yln | PUTATIVE ABCTRANSPORTER,PERIPLASMIC BINDINGPROTEIN, AMINO ACID (Neisseriagonorrhoeae) |
PF00497(SBP_bac_3) | 5 | GLY A 233GLY A 231VAL A 116LEU A 118SER A 130 | NoneGOL A1283 (-3.4A)CYS A 500 (-3.6A)NoneNone | 0.87A | 4f84A-2ylnA:undetectable | 4f84A-2ylnA:26.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zfu | CEREBRAL PROTEIN 1 (Homo sapiens) |
PF05148(Methyltransf_8) | 5 | GLY A 316GLY A 318LEU A 335MET A 347SER A 365 | SAH A 900 (-3.5A)SAH A 900 ( 3.7A)SAH A 900 (-4.2A)SAH A 900 (-3.6A)SAH A 900 (-4.7A) | 0.46A | 4f84A-2zfuA:12.7 | 4f84A-2zfuA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ak5 | HEMOGLOBIN-BINDINGPROTEASE HBP (Escherichiacoli) |
PF02395(Peptidase_S6) | 5 | GLY A 53THR A 218LEU A 217SER A 261VAL A 105 | None | 1.21A | 4f84A-3ak5A:undetectable | 4f84A-3ak5A:15.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cp2 | TRNA URIDINE5-CARBOXYMETHYLAMINOMETHYL MODIFICATIONENZYME GIDA (Escherichiacoli) |
PF01134(GIDA)PF13932(GIDA_assoc) | 5 | GLY A 13GLY A 18VAL A 155THR A 154LEU A 153 | NoneNoneSO4 A 630 ( 3.4A)SO4 A 630 ( 4.6A)None | 1.07A | 4f84A-3cp2A:2.5 | 4f84A-3cp2A:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d2l | SAM-DEPENDENTMETHYLTRANSFERASE (Exiguobacteriumsibiricum) |
PF13649(Methyltransf_25) | 5 | GLY A 40GLY A 42VAL A 59LEU A 61SER A 105 | None | 0.84A | 4f84A-3d2lA:18.2 | 4f84A-3d2lA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3elu | METHYLTRANSFERASE (Wesselsbronvirus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 5 | GLY A 81GLY A 83THR A 104LEU A 105ASN A 131 | SAM A4633 (-3.2A)SAM A4633 (-3.4A)SAM A4633 (-4.5A)SAM A4633 (-4.1A)SAM A4633 (-3.6A) | 0.56A | 4f84A-3eluA:8.0 | 4f84A-3eluA:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ff1 | GLUCOSE-6-PHOSPHATEISOMERASE (Staphylococcusaureus) |
PF00342(PGI) | 5 | GLY A 141GLY A 179LEU A 184SER A 138VAL A 136 | None | 1.16A | 4f84A-3ff1A:undetectable | 4f84A-3ff1A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fj4 | MUCONATECYCLOISOMERASE (Pseudomonasprotegens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 280THR A 285LEU A 286SER A 112VAL A 126 | None | 1.23A | 4f84A-3fj4A:undetectable | 4f84A-3fj4A:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g05 | TRNA URIDINE5-CARBOXYMETHYLAMINOMETHYL MODIFICATIONENZYME MNMG (Escherichiacoli) |
PF01134(GIDA)PF13932(GIDA_assoc) | 5 | GLY A 13GLY A 18VAL A 155THR A 154LEU A 153 | NoneSO4 A 551 (-4.8A)SO4 A 551 ( 4.9A)SO4 A 551 ( 4.7A)None | 1.21A | 4f84A-3g05A:2.9 | 4f84A-3g05A:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g0t | PUTATIVEAMINOTRANSFERASE (Porphyromonasgingivalis) |
PF00155(Aminotran_1_2) | 5 | GLY A 112GLY A 116VAL A 111THR A 110SER A 256 | LLP A 259 ( 3.5A)NoneNoneNoneLLP A 259 ( 2.5A) | 1.16A | 4f84A-3g0tA:3.4 | 4f84A-3g0tA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gc3 | BETA-ARRESTIN-1 (Bos taurus) |
PF00339(Arrestin_N)PF02752(Arrestin_C) | 5 | GLY A 141VAL A 127THR A 128LEU A 129TYR A 63 | None | 1.22A | 4f84A-3gc3A:undetectable | 4f84A-3gc3A:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3il2 | REDOX-SENSINGTRANSCRIPTIONALREPRESSOR REX (Thermusthermophilus) |
PF02629(CoA_binding)PF06971(Put_DNA-bind_N) | 5 | GLY A 87GLY A 92THR A 147LEU A 146VAL A 130 | None | 1.12A | 4f84A-3il2A:undetectable | 4f84A-3il2A:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2p | REVERSETRANSCRIPTASE (Humanimmunodeficiencyvirus 1) |
PF00075(RNase_H) | 5 | GLY A 490VAL A 531LEU A 486TYR A 457VAL A 442 | None | 1.18A | 4f84A-3k2pA:2.1 | 4f84A-3k2pA:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k55 | BETA-HEMOLYSIN (Staphylococcusaureus) |
PF03372(Exo_endo_phos) | 5 | GLY A 100GLY A 79VAL A 102GLN A 115SER A 128 | None | 1.21A | 4f84A-3k55A:2.1 | 4f84A-3k55A:24.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nix | FLAVOPROTEIN/DEHYDROGENASE (Cytophagahutchinsonii) |
PF01494(FAD_binding_3) | 5 | GLY A 17GLY A 14VAL A 19THR A 18VAL A 31 | NoneFAD A 501 ( 3.8A)NoneNoneNone | 1.16A | 4f84A-3nixA:2.4 | 4f84A-3nixA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ol2 | SEMAPHORIN-4D (Homo sapiens) |
PF00047(ig)PF01403(Sema)PF01437(PSI) | 5 | GLY A 490GLY A 494VAL A 473LEU A 466VAL A 487 | None | 1.23A | 4f84A-3ol2A:undetectable | 4f84A-3ol2A:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pu2 | UNCHARACTERIZEDPROTEIN (Rhodobactersphaeroides) |
PF08327(AHSA1) | 5 | GLY A 90THR A 89LEU A 88SER A 104VAL A 118 | None | 1.18A | 4f84A-3pu2A:undetectable | 4f84A-3pu2A:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qfk | UNCHARACTERIZEDPROTEIN (Staphylococcusaureus) |
PF00149(Metallophos)PF02872(5_nucleotid_C) | 5 | GLY A 252GLY A 249VAL A 255THR A 254GLN A 235 | None | 1.15A | 4f84A-3qfkA:2.5 | 4f84A-3qfkA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qha | PUTATIVEOXIDOREDUCTASE (Mycobacteriumavium) |
PF03446(NAD_binding_2)PF14833(NAD_binding_11) | 5 | GLY A 18GLY A 23VAL A 74THR A 73VAL A 61 | None | 1.02A | 4f84A-3qhaA:5.1 | 4f84A-3qhaA:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qha | PUTATIVEOXIDOREDUCTASE (Mycobacteriumavium) |
PF03446(NAD_binding_2)PF14833(NAD_binding_11) | 5 | GLY A 18GLY A 23VAL A 74THR A 73VAL A 64 | None | 0.92A | 4f84A-3qhaA:5.1 | 4f84A-3qhaA:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qj4 | RENALASE (Homo sapiens) |
PF01593(Amino_oxidase)PF13450(NAD_binding_8) | 5 | GLY A 8GLY A 13THR A 160LEU A 159VAL A 132 | FAD A 401 (-3.3A)NoneNoneNoneFAD A 401 (-4.1A) | 1.18A | 4f84A-3qj4A:2.4 | 4f84A-3qj4A:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rh0 | ARSENATE REDUCTASE (Corynebacteriumglutamicum) |
PF01451(LMWPc) | 5 | GLY A 13GLY A 10LEU A 80MET A 17VAL A 115 | OCS A 8 ( 4.5A)OCS A 8 ( 4.1A)NoneNoneNone | 1.12A | 4f84A-3rh0A:2.4 | 4f84A-3rh0A:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s2u | UDP-N-ACETYLGLUCOSAMINE--N-ACETYLMURAMYL-(PENTAPEPTIDE)PYROPHOSPHORYL-UNDECAPRENOLN-ACETYLGLUCOSAMINETRANSFERASE (Pseudomonasaeruginosa) |
PF03033(Glyco_transf_28)PF04101(Glyco_tran_28_C) | 5 | GLY A 261VAL A 265THR A 264LEU A 263ASN A 160 | UD1 A 366 (-3.2A)NoneUD1 A 366 (-2.8A)UD1 A 366 (-3.8A)None | 1.01A | 4f84A-3s2uA:4.0 | 4f84A-3s2uA:24.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u0f | BETA-KETOACYLSYNTHASE (Brucellaabortus) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 336GLY A 105THR A 163ASN A 165SER A 334 | None07L A 411 (-3.3A)NoneNoneNone | 1.06A | 4f84A-3u0fA:undetectable | 4f84A-3u0fA:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uyu | ANTIFREEZE PROTEIN (Leucosporidiumsp. AY30) |
PF11999(DUF3494) | 5 | GLY A 169GLY A 194VAL A 197GLN A 192SER A 145 | None | 1.22A | 4f84A-3uyuA:undetectable | 4f84A-3uyuA:20.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vc1 | GERANYL DIPHOSPHATE2-C-METHYLTRANSFERASE (Streptomycescoelicolor) |
PF08241(Methyltransf_11) | 11 | GLY A 105GLY A 107VAL A 126THR A 127LEU A 128GLN A 132ASN A 155MET A 156SER A 174TYR A 177VAL A 178 | SAH A 302 (-3.4A)SAH A 302 (-3.3A)SAH A 302 ( 4.9A)SAH A 302 (-4.0A)SAH A 302 (-4.1A)SAH A 302 (-3.1A)GOL A 304 ( 3.4A)SAH A 302 (-3.9A)SAH A 302 (-4.5A)SAH A 302 ( 3.9A)None | 0.46A | 4f84A-3vc1A:39.4 | 4f84A-3vc1A:85.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wgk | CELL DIVISIONPROTEIN FTSZ (Staphylococcusaureus) |
PF00091(Tubulin)PF12327(FtsZ_C) | 5 | GLY A 110GLY A 106THR A 111SER A 103VAL A 101 | GDP A 400 (-3.4A)GDP A 400 ( 4.7A)NoneNoneNone | 1.09A | 4f84A-3wgkA:3.5 | 4f84A-3wgkA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b9i | CS6 FIMBRIAL SUBUNITA, CS6 FIMBRIALSUBUNIT B (Escherichiacoli) |
no annotation | 5 | GLY A 126VAL A 125THR A 50TYR A 128VAL A 46 | None | 1.22A | 4f84A-4b9iA:undetectable | 4f84A-4b9iA:14.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dsh | UDP-GALACTOPYRANOSEMUTASE (Trypanosomacruzi) |
PF01593(Amino_oxidase)PF13450(NAD_binding_8) | 5 | GLY A 13GLY A 15VAL A 263THR A 262VAL A 10 | FDA A 502 (-3.3A)FDA A 502 (-3.2A)FDA A 502 (-3.9A)FDA A 502 ( 4.4A)None | 1.19A | 4f84A-4dshA:undetectable | 4f84A-4dshA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ej6 | PUTATIVEZINC-BINDINGDEHYDROGENASE (Sinorhizobiummeliloti) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 172VAL A 176THR A 175LEU A 174VAL A 333 | CL A 419 (-3.9A)NoneNoneNoneNone | 1.11A | 4f84A-4ej6A:6.8 | 4f84A-4ej6A:26.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4evi | CONIFERYL ALCOHOL9-O-METHYLTRANSFERASE (Linumnodiflorum) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 5 | GLY A 208GLY A 210ASN A 252MET A 253TYR A 162 | SAH A 401 (-3.6A)SAH A 401 ( 3.8A)SAH A 401 (-3.3A)SAH A 401 (-4.1A)SAH A 401 ( 3.6A) | 1.10A | 4f84A-4eviA:13.2 | 4f84A-4eviA:26.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4evi | CONIFERYL ALCOHOL9-O-METHYLTRANSFERASE (Linumnodiflorum) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 5 | GLY A 208GLY A 210LEU A 232ASN A 252MET A 253 | SAH A 401 (-3.6A)SAH A 401 ( 3.8A)SAH A 401 ( 4.4A)SAH A 401 (-3.3A)SAH A 401 (-4.1A) | 0.65A | 4f84A-4eviA:13.2 | 4f84A-4eviA:26.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4f85 | GERANYL DIPHOSPHATE2-C-METHYLTRANSFERASE (Streptomyceslasaliensis) |
PF02353(CMAS) | 12 | HIS A 57GLY A 113GLY A 115VAL A 134THR A 135LEU A 136GLN A 140ASN A 163MET A 164SER A 182TYR A 185VAL A 186 | None | 0.27A | 4f84A-4f85A:42.8 | 4f84A-4f85A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fz2 | TRNA INTRONENDONUCLEASE (CandidatusMicrarchaeumacidiphilum) |
PF01974(tRNA_int_endo) | 5 | GLY A 128VAL A 138THR A 137LEU A 171ASN A 169 | None | 1.24A | 4f84A-4fz2A:undetectable | 4f84A-4fz2A:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hb9 | SIMILARITIES WITHPROBABLEMONOOXYGENASE (Photorhabduslaumondii) |
PF01494(FAD_binding_3) | 5 | GLY A 12GLY A 9THR A 13LEU A 121VAL A 26 | NoneFAD A 501 (-3.2A)NoneNoneNone | 1.04A | 4f84A-4hb9A:2.9 | 4f84A-4hb9A:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jxk | OXIDOREDUCTASE (Rhodococcusopacus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 162GLY A 159VAL A 164THR A 163VAL A 176 | None | 1.03A | 4f84A-4jxkA:7.1 | 4f84A-4jxkA:25.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kqk | NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLEPHOSPHORIBOSYLTRANSFERASE (Salmonellaenterica) |
PF02277(DBI_PRT) | 5 | GLY A 166VAL A 167THR A 168LEU A 258GLN A 57 | None | 1.17A | 4f84A-4kqkA:undetectable | 4f84A-4kqkA:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m1r | CELLULASE 5 (soil metagenome) |
PF00150(Cellulase) | 5 | GLY A 61GLY A 66VAL A 62ASN A 131SER A 29 | NoneNoneNoneTRS A 301 (-3.3A)None | 1.16A | 4f84A-4m1rA:undetectable | 4f84A-4m1rA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ng4 | PHOSPHOGLYCERATEKINASE (Coxiellaburnetii) |
PF00162(PGK) | 5 | GLY A 347GLY A 349THR A 351LEU A 355SER A 368 | NoneADP A 402 (-4.0A)ADP A 402 (-3.5A)NoneNone | 1.25A | 4f84A-4ng4A:2.8 | 4f84A-4ng4A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o0e | ISOASPARTYLPEPTIDASE/L-ASPARAGINASE (Homo sapiens) |
PF01112(Asparaginase_2) | 5 | GLY A 167GLY A 220VAL A 169THR A 168VAL A 68 | None | 1.08A | 4f84A-4o0eA:undetectable | 4f84A-4o0eA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ozi | T-CELL RECEPTOR, S2,BETA CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 5 | GLY F 107GLY F 110VAL F 108THR F 113VAL F 4 | None | 1.21A | 4f84A-4oziF:undetectable | 4f84A-4oziF:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p1c | TOLUENE-4-MONOOXYGENASE SYSTEM PROTEIN A (Pseudomonasmendocina) |
PF02332(Phenol_Hydrox) | 5 | GLY A 274THR A 273LEU A 272TYR A 331VAL A 335 | None | 1.12A | 4f84A-4p1cA:undetectable | 4f84A-4p1cA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pj3 | INTRON-BINDINGPROTEIN AQUARIUS (Homo sapiens) |
PF13086(AAA_11)PF13087(AAA_12)PF16399(Aquarius_N) | 5 | GLY A1202GLY A1189VAL A1182ASN A1357MET A1358 | None | 1.17A | 4f84A-4pj3A:2.7 | 4f84A-4pj3A:12.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pne | METHYLTRANSFERASE-LIKE PROTEIN (Saccharopolysporaspinosa) |
PF08241(Methyltransf_11) | 5 | GLY A 80GLY A 82THR A 102GLN A 107SER A 149 | SAH A 301 (-2.7A)SAH A 301 (-2.9A)SAH A 301 (-3.3A)SAH A 301 (-3.1A)SAH A 301 (-4.7A) | 0.48A | 4f84A-4pneA:25.8 | 4f84A-4pneA:29.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4udr | GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE (Methylovorussp. MP688) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | GLY A 12GLY A 17THR A 265LEU A 264VAL A 233 | FAD A 700 (-3.2A)NoneNoneNoneFAD A 700 (-4.0A) | 1.21A | 4f84A-4udrA:2.2 | 4f84A-4udrA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ydl | HEAVY CHAIN OFANTIBODYC38-VRC18.02LIGHT CHAIN OFANTIBODYC38-VRC18.02 (Homo sapiens;Homo sapiens) |
no annotationno annotation | 5 | HIS H 35GLY H 95LEU L 46GLN L 89VAL H 2 | NoneNoneNoneNonePCA H 1 ( 3.3A) | 1.17A | 4f84A-4ydlH:undetectable | 4f84A-4ydlH:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5avo | HOMOSERINEDEHYDROGENASE (Sulfurisphaeratokodaii) |
PF00742(Homoserine_dh)PF03447(NAD_binding_3) | 5 | GLY A 282GLY A 280VAL A 263ASN A 155SER A 131 | None | 1.21A | 4f84A-5avoA:undetectable | 4f84A-5avoA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b6h | ADENINEPHOSPHORIBOSYLTRANSFERASE (Yersiniapseudotuberculosis) |
PF00156(Pribosyltran) | 5 | GLY A 66GLY A 71VAL A 89THR A 67VAL A 126 | None NA A 502 ( 4.7A)NoneNoneNone | 1.20A | 4f84A-5b6hA:undetectable | 4f84A-5b6hA:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5doo | PROTEIN LYSINEMETHYLTRANSFERASE 2 (Rickettsiatyphi) |
PF10119(MethyTransf_Reg)PF13847(Methyltransf_31) | 5 | GLY A 51GLY A 53LEU A 75GLN A 79VAL A 124 | None | 1.09A | 4f84A-5dooA:15.3 | 4f84A-5dooA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ff5 | PAAA (Pantoeaagglomerans) |
PF00899(ThiF) | 5 | GLY A 144GLY A 141THR A 145LEU A 177GLN A 175 | NoneSO4 A 401 ( 3.7A)NoneNoneSO4 A 401 (-3.7A) | 1.23A | 4f84A-5ff5A:4.8 | 4f84A-5ff5A:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ff5 | PAAA (Pantoeaagglomerans) |
PF00899(ThiF) | 5 | GLY A 144GLY A 142THR A 145LEU A 177GLN A 175 | NoneSO4 A 401 (-3.6A)NoneNoneSO4 A 401 (-3.7A) | 1.24A | 4f84A-5ff5A:4.8 | 4f84A-5ff5A:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ffn | ENZYME SUBTILASESUBTY FROM BACILLUSSP. TY145 (Bacillus sp.(in: Bacteria)) |
PF00082(Peptidase_S8) | 5 | GLY A 73GLY A 71THR A 36LEU A 106GLN A 70 | None | 1.10A | 4f84A-5ffnA:undetectable | 4f84A-5ffnA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gm2 | O-METHYLRANSFERASE (Streptomycesblastmyceticus) |
PF08241(Methyltransf_11) | 5 | GLY A 85GLY A 87VAL A 106GLN A 112SER A 154 | SAH A 301 (-3.2A)SAH A 301 (-3.1A)NoneSAH A 301 (-2.6A)SAH A 301 (-4.4A) | 0.40A | 4f84A-5gm2A:25.8 | 4f84A-5gm2A:24.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ijz | NADP-SPECIFICGLUTAMATEDEHYDROGENASE (Corynebacteriumglutamicum) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | GLY A 129GLY A 93VAL A 82GLN A 113VAL A 101 | NoneAKG A 502 (-3.4A)NoneAKG A 502 (-2.9A)None | 1.15A | 4f84A-5ijzA:3.9 | 4f84A-5ijzA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j84 | DIHYDROXY-ACIDDEHYDRATASE (Rhizobiumleguminosarum) |
PF00920(ILVD_EDD) | 5 | GLY A 274GLY A 380THR A 308LEU A 376ASN A 311 | None | 1.18A | 4f84A-5j84A:undetectable | 4f84A-5j84A:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k94 | MALTOSE-BINDINGPERIPLASMICPROTEIN,PROTEINTRANSLOCASE SUBUNITSECA,MALTOSE-BINDINGPERIPLASMIC PROTEIN (Escherichiacoli) |
PF01043(SecA_PP_bind)PF01547(SBP_bac_1)PF13416(SBP_bac_8) | 5 | GLY A 278GLY A 261THR A 275GLN A 249VAL A 310 | None | 1.19A | 4f84A-5k94A:undetectable | 4f84A-5k94A:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o4u | FLAGELLIN (Pyrococcusfuriosus) |
PF01917(Arch_flagellin) | 5 | GLY A 166GLY A 168VAL A 171ASN A 98TYR A 70 | None | 1.24A | 4f84A-5o4uA:undetectable | 4f84A-5o4uA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ttk | AMINE OXIDASE (Pseudomonasputida) |
PF01593(Amino_oxidase) | 5 | GLY A 60GLY A 62VAL A 308THR A 307VAL A 57 | FAD A 501 (-3.1A)FAD A 501 (-3.5A)FAD A 501 (-4.1A)NoneNone | 1.23A | 4f84A-5ttkA:undetectable | 4f84A-5ttkA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5unn | NADPH-DEPENDENTGLYOXYLATE/HYDROXYPYRUVATE REDUCTASE (Sinorhizobiummeliloti) |
PF02826(2-Hacid_dh_C) | 5 | GLY A 143GLY A 167VAL A 197LEU A 158VAL A 140 | None | 1.13A | 4f84A-5unnA:6.8 | 4f84A-5unnA:24.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xvi | GLUTAMATEDEHYDROGENASE (Aspergillusniger) |
no annotation | 5 | GLY A 115GLY A 79VAL A 68GLN A 99VAL A 87 | None | 1.18A | 4f84A-5xviA:5.1 | 4f84A-5xviA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6apx | MONOBODY YSX1 (syntheticconstruct) |
no annotation | 5 | GLY B 75GLY B 80VAL B 29TYR B 73VAL B 72 | None | 1.23A | 4f84A-6apxB:undetectable | 4f84A-6apxB:14.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6at7 | PHENYLALANINEAMMONIA-LYASE (Sorghum bicolor) |
no annotation | 5 | GLY A 481GLY A 252THR A 188ASN A 478SER A 484 | NoneNoneMDO A 190 ( 4.4A)NoneNone | 1.18A | 4f84A-6at7A:undetectable | 4f84A-6at7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bqc | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPIDSYNTHASE (Escherichiacoli) |
no annotation | 5 | GLY A 175GLY A 177VAL A 196THR A 197GLN A 202 | None | 0.48A | 4f84A-6bqcA:23.7 | 4f84A-6bqcA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cia | ALDO/KETO REDUCTASE (Klebsiellapneumoniae) |
no annotation | 5 | GLY A 158THR A 155LEU A 120GLN A 121VAL A 141 | None | 1.23A | 4f84A-6ciaA:undetectable | 4f84A-6ciaA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cr0 | (S)-6-HYDROXYNICOTINE OXIDASE (Shinella sp.HZN7) |
no annotation | 5 | GLY A 12GLY A 17THR A 259LEU A 258VAL A 231 | FAD A 507 (-3.4A)NoneNoneNoneFAD A 507 (-3.8A) | 1.20A | 4f84A-6cr0A:undetectable | 4f84A-6cr0A:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f45 | - (-) |
no annotation | 5 | GLY D 158GLY D 156VAL D 121SER D 218TYR D 204 | None | 1.15A | 4f84A-6f45D:undetectable | 4f84A-6f45D:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gkv | COCLAURINEN-METHYLTRANSFERASE (Coptis japonica) |
no annotation | 5 | GLY A 137GLY A 139VAL A 159THR A 160GLN A 165 | SAH A 501 (-3.5A)SAH A 501 (-3.1A)NoneSAH A 501 ( 4.8A)SAH A 501 (-2.7A) | 0.51A | 4f84A-6gkvA:20.0 | 4f84A-6gkvA:undetectable |