SIMILAR PATTERNS OF AMINO ACIDS FOR 4F84_A_SAMA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE


(Trypanosoma
brucei)
PF00162
(PGK)
5 GLY A 352
GLY A 342
THR A 353
TYR A 325
VAL A 326
None
ADP  A 421 (-3.1A)
None
None
None
0.78A 4f84A-13pkA:
2.0
4f84A-13pkA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ayy GLYCOSYLASPARAGINASE

(Elizabethkingia
meningoseptica)
PF01112
(Asparaginase_2)
5 GLY B 214
GLY B 188
VAL B 218
THR B 215
VAL B 255
None
1.21A 4f84A-1ayyB:
undetectable
4f84A-1ayyB:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chd CHEB METHYLESTERASE

(Salmonella
enterica)
PF01339
(CheB_methylest)
5 GLY A 282
GLY A 166
THR A 281
MET A 314
VAL A 260
None
1.23A 4f84A-1chdA:
undetectable
4f84A-1chdA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyd CARBONYL REDUCTASE

(Mus musculus)
PF13561
(adh_short_C2)
5 GLY A  14
GLY A  16
VAL A  37
THR A  38
VAL A 106
NDP  A 245 (-3.0A)
NDP  A 245 (-3.7A)
None
NDP  A 245 (-4.0A)
NDP  A 245 (-4.2A)
0.98A 4f84A-1cydA:
6.6
4f84A-1cydA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyg CYCLODEXTRIN
GLUCANOTRANSFERASE


(Geobacillus
stearothermophilus)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C)
5 GLY A 481
GLY A 479
VAL A 430
LEU A 460
MET A 340
None
1.24A 4f84A-1cygA:
undetectable
4f84A-1cygA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE


(Cyberlindnera
saturnus)
PF00291
(PALP)
5 GLY A 172
GLY A 208
THR A 245
LEU A 248
TYR A  57
None
1.13A 4f84A-1f2dA:
undetectable
4f84A-1f2dA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
5 GLY A  29
GLY A  27
THR A  20
GLN A 424
VAL A  85
None
F3S  A5005 (-3.9A)
None
None
None
1.25A 4f84A-1g8kA:
2.6
4f84A-1g8kA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqe HISTAMINE
N-METHYLTRANSFERASE


(Homo sapiens)
PF13489
(Methyltransf_23)
5 GLY A  60
GLY A  62
VAL A  88
TYR A 147
VAL A 148
SAH  A 400 (-3.3A)
SAH  A 400 (-3.2A)
None
QUN  A 500 ( 3.6A)
SAH  A 400 ( 4.8A)
0.67A 4f84A-1jqeA:
13.6
4f84A-1jqeA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kph CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 1


(Mycobacterium
tuberculosis)
PF02353
(CMAS)
5 GLY A  72
GLY A  74
THR A  94
LEU A  95
GLN A  99
SAH  A1900 (-3.1A)
SAH  A1900 (-3.2A)
SAH  A1900 (-4.0A)
SAH  A1900 (-4.4A)
SAH  A1900 (-2.9A)
0.42A 4f84A-1kphA:
25.1
4f84A-1kphA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpi CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 2


(Mycobacterium
tuberculosis)
PF02353
(CMAS)
5 GLY A  80
GLY A  82
THR A 102
LEU A 103
GLN A 107
SAH  A 900 (-3.3A)
SAH  A 900 (-3.1A)
SAH  A 900 (-4.0A)
SAH  A 900 (-4.4A)
SAH  A 900 (-2.9A)
0.41A 4f84A-1kpiA:
24.0
4f84A-1kpiA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1e MYCOLIC ACID
SYNTHASE


(Mycobacterium
tuberculosis)
PF02353
(CMAS)
5 GLY A  72
GLY A  74
THR A  94
LEU A  95
GLN A  99
SAH  A 900 (-3.1A)
SAH  A 900 (-3.4A)
SAH  A 900 (-4.4A)
SAH  A 900 (-4.1A)
SAH  A 900 (-3.1A)
0.46A 4f84A-1l1eA:
25.4
4f84A-1l1eA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mns MANDELATE RACEMASE

(Pseudomonas
putida)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLY A 106
GLY A 276
SER A  49
TYR A  50
VAL A  35
None
1.05A 4f84A-1mnsA:
undetectable
4f84A-1mnsA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri3 MRNA CAPPING ENZYME

(Encephalitozoon
cuniculi)
PF03291
(Pox_MCEL)
5 GLY A  72
GLY A  74
VAL A  93
SER A 142
TYR A 145
SAH  A 299 (-3.3A)
SAH  A 299 (-3.5A)
None
SAH  A 299 (-3.0A)
SAH  A 299 (-4.2A)
0.79A 4f84A-1ri3A:
16.9
4f84A-1ri3A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgl TRICHOMAGLIN

(Trichosanthes
lepiniana)
PF00445
(Ribonuclease_T2)
5 GLY A 174
VAL A 176
LEU A 151
SER A 197
VAL A 195
None
1.24A 4f84A-1sglA:
undetectable
4f84A-1sglA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tpy METHOXY MYCOLIC ACID
SYNTHASE 2


(Mycobacterium
tuberculosis)
PF02353
(CMAS)
5 GLY A  72
GLY A  74
THR A  94
LEU A  95
GLN A  99
SAH  A1900 (-3.2A)
SAH  A1900 (-3.3A)
SAH  A1900 (-4.1A)
SAH  A1900 (-4.3A)
SAH  A1900 (-3.0A)
0.47A 4f84A-1tpyA:
25.5
4f84A-1tpyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis)
PF07745
(Glyco_hydro_53)
5 GLY A 314
GLY A 311
VAL A 307
LEU A 248
VAL A 228
None
0.93A 4f84A-1ur4A:
undetectable
4f84A-1ur4A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE


(Clostridium
acetobutylicum)
PF13649
(Methyltransf_25)
5 GLY A  48
VAL A  66
LEU A  68
SER A 112
TYR A 115
None
1.03A 4f84A-1y8cA:
16.6
4f84A-1y8cA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avn UBIQUINONE/MENAQUINO
NE BIOSYNTHESIS
METHYLTRANSFERASE-RE
LATED PROTEIN


(Thermotoga
maritima)
PF08241
(Methyltransf_11)
5 GLY A  50
GLY A  52
VAL A  70
TYR A 115
VAL A 116
SAI  A1300 (-3.5A)
SAI  A1300 (-3.5A)
None
SAI  A1300 (-4.8A)
SAI  A1300 ( 4.0A)
1.01A 4f84A-2avnA:
15.2
4f84A-2avnA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cun PHOSPHOGLYCERATE
KINASE


(Pyrococcus
horikoshii)
PF00162
(PGK)
5 GLY A 339
GLY A 329
VAL A 341
THR A 340
TYR A 312
None
1.06A 4f84A-2cunA:
undetectable
4f84A-2cunA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE


(Escherichia
coli)
PF00156
(Pribosyltran)
5 GLY A  62
GLY A  67
VAL A  85
THR A  63
VAL A 122
None
1.21A 4f84A-2dy0A:
3.8
4f84A-2dy0A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE


(Candida
tropicalis)
PF00106
(adh_short)
5 GLY A  15
GLY A  17
LEU A  40
ASN A  74
VAL A 121
None
1.10A 4f84A-2et6A:
6.7
4f84A-2et6A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4


(Mycobacterium
tuberculosis)
PF02353
(CMAS)
5 GLY A  81
GLY A  83
THR A 103
LEU A 104
GLN A 108
None
0.55A 4f84A-2fk7A:
24.6
4f84A-2fk7A:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm4 PYRUVATE, PHOSPHATE
DIKINASE


([Clostridium]
symbiosum)
PF00391
(PEP-utilizers)
5 GLY A 470
GLY A 450
VAL A 448
THR A 447
LEU A 446
None
1.20A 4f84A-2fm4A:
undetectable
4f84A-2fm4A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fsr ACETYLTRANSFERASE

(Agrobacterium
fabrum)
PF13302
(Acetyltransf_3)
5 GLY A  94
GLY A  81
SER A 129
TYR A 130
VAL A 131
None
1.24A 4f84A-2fsrA:
undetectable
4f84A-2fsrA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe)
PF00743
(FMO-like)
PF13450
(NAD_binding_8)
5 GLY A  18
GLY A  15
VAL A  20
LEU A 128
VAL A  34
None
FAD  A 500 (-3.4A)
None
None
None
1.11A 4f84A-2gv8A:
undetectable
4f84A-2gv8A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)


(Homo sapiens)
PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP)
5 GLY A 191
GLY A 187
LEU A 227
TYR A 265
VAL A 263
None
0.98A 4f84A-2hgsA:
undetectable
4f84A-2hgsA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opi L-FUCULOSE-1-PHOSPHA
TE ALDOLASE


(Bacteroides
thetaiotaomicron)
PF00596
(Aldolase_II)
5 HIS A 158
GLY A 159
LEU A  92
SER A  27
VAL A  47
None
1.18A 4f84A-2opiA:
undetectable
4f84A-2opiA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq2 PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE


(Saccharomyces
cerevisiae)
PF01507
(PAPS_reduct)
5 GLY A  54
GLY A 158
VAL A  56
THR A  53
LEU A  52
A3P  A 999 (-3.1A)
A3P  A 999 (-3.2A)
None
A3P  A 999 ( 4.6A)
None
1.21A 4f84A-2oq2A:
undetectable
4f84A-2oq2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy1 PECTATE LYASE II

(Xanthomonas
campestris)
PF00544
(Pec_lyase_C)
5 GLY A  24
LEU A 351
ASN A 124
SER A 190
TYR A 191
None
1.23A 4f84A-2qy1A:
undetectable
4f84A-2qy1A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzb UNCHARACTERIZED
PROTEIN YFEY


(Escherichia
coli)
PF06572
(DUF1131)
5 GLY A  99
GLY A 102
VAL A  82
ASN A  78
SER A 105
None
1.20A 4f84A-2qzbA:
undetectable
4f84A-2qzbA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes)
PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid)
5 GLY A  84
GLY A 107
THR A  55
LEU A  58
SER A 117
None
1.08A 4f84A-2wyhA:
undetectable
4f84A-2wyhA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y77 3-DEHYDROQUINATE
DEHYDRATASE


(Mycobacterium
tuberculosis)
PF01220
(DHquinase_II)
5 HIS A  81
GLY A  78
LEU A  86
SER A 115
TYR A 116
CB8  A1144 (-3.8A)
CB8  A1144 (-3.3A)
None
None
None
1.23A 4f84A-2y77A:
undetectable
4f84A-2y77A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfh GLUTAMATE
DEHYDROGENASE,
NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE,
GLUTAMATE
DEHYDROGENASE


(Escherichia
coli;
[Clostridium]
symbiosum)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 GLY A 127
GLY A  91
VAL A  80
GLN A 111
VAL A  99
None
1.18A 4f84A-2yfhA:
4.3
4f84A-2yfhA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID


(Neisseria
gonorrhoeae)
PF00497
(SBP_bac_3)
5 GLY A 233
GLY A 231
VAL A 116
LEU A 118
SER A 130
None
GOL  A1283 (-3.4A)
CYS  A 500 (-3.6A)
None
None
0.87A 4f84A-2ylnA:
undetectable
4f84A-2ylnA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfu CEREBRAL PROTEIN 1

(Homo sapiens)
PF05148
(Methyltransf_8)
5 GLY A 316
GLY A 318
LEU A 335
MET A 347
SER A 365
SAH  A 900 (-3.5A)
SAH  A 900 ( 3.7A)
SAH  A 900 (-4.2A)
SAH  A 900 (-3.6A)
SAH  A 900 (-4.7A)
0.46A 4f84A-2zfuA:
12.7
4f84A-2zfuA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP


(Escherichia
coli)
PF02395
(Peptidase_S6)
5 GLY A  53
THR A 218
LEU A 217
SER A 261
VAL A 105
None
1.21A 4f84A-3ak5A:
undetectable
4f84A-3ak5A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA


(Escherichia
coli)
PF01134
(GIDA)
PF13932
(GIDA_assoc)
5 GLY A  13
GLY A  18
VAL A 155
THR A 154
LEU A 153
None
None
SO4  A 630 ( 3.4A)
SO4  A 630 ( 4.6A)
None
1.07A 4f84A-3cp2A:
2.5
4f84A-3cp2A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2l SAM-DEPENDENT
METHYLTRANSFERASE


(Exiguobacterium
sibiricum)
PF13649
(Methyltransf_25)
5 GLY A  40
GLY A  42
VAL A  59
LEU A  61
SER A 105
None
0.84A 4f84A-3d2lA:
18.2
4f84A-3d2lA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3elu METHYLTRANSFERASE

(Wesselsbron
virus)
PF00972
(Flavi_NS5)
PF01728
(FtsJ)
5 GLY A  81
GLY A  83
THR A 104
LEU A 105
ASN A 131
SAM  A4633 (-3.2A)
SAM  A4633 (-3.4A)
SAM  A4633 (-4.5A)
SAM  A4633 (-4.1A)
SAM  A4633 (-3.6A)
0.56A 4f84A-3eluA:
8.0
4f84A-3eluA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff1 GLUCOSE-6-PHOSPHATE
ISOMERASE


(Staphylococcus
aureus)
PF00342
(PGI)
5 GLY A 141
GLY A 179
LEU A 184
SER A 138
VAL A 136
None
1.16A 4f84A-3ff1A:
undetectable
4f84A-3ff1A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj4 MUCONATE
CYCLOISOMERASE


(Pseudomonas
protegens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLY A 280
THR A 285
LEU A 286
SER A 112
VAL A 126
None
1.23A 4f84A-3fj4A:
undetectable
4f84A-3fj4A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG


(Escherichia
coli)
PF01134
(GIDA)
PF13932
(GIDA_assoc)
5 GLY A  13
GLY A  18
VAL A 155
THR A 154
LEU A 153
None
SO4  A 551 (-4.8A)
SO4  A 551 ( 4.9A)
SO4  A 551 ( 4.7A)
None
1.21A 4f84A-3g05A:
2.9
4f84A-3g05A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0t PUTATIVE
AMINOTRANSFERASE


(Porphyromonas
gingivalis)
PF00155
(Aminotran_1_2)
5 GLY A 112
GLY A 116
VAL A 111
THR A 110
SER A 256
LLP  A 259 ( 3.5A)
None
None
None
LLP  A 259 ( 2.5A)
1.16A 4f84A-3g0tA:
3.4
4f84A-3g0tA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gc3 BETA-ARRESTIN-1

(Bos taurus)
PF00339
(Arrestin_N)
PF02752
(Arrestin_C)
5 GLY A 141
VAL A 127
THR A 128
LEU A 129
TYR A  63
None
1.22A 4f84A-3gc3A:
undetectable
4f84A-3gc3A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX


(Thermus
thermophilus)
PF02629
(CoA_binding)
PF06971
(Put_DNA-bind_N)
5 GLY A  87
GLY A  92
THR A 147
LEU A 146
VAL A 130
None
1.12A 4f84A-3il2A:
undetectable
4f84A-3il2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2p REVERSE
TRANSCRIPTASE


(Human
immunodeficiency
virus 1)
PF00075
(RNase_H)
5 GLY A 490
VAL A 531
LEU A 486
TYR A 457
VAL A 442
None
1.18A 4f84A-3k2pA:
2.1
4f84A-3k2pA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k55 BETA-HEMOLYSIN

(Staphylococcus
aureus)
PF03372
(Exo_endo_phos)
5 GLY A 100
GLY A  79
VAL A 102
GLN A 115
SER A 128
None
1.21A 4f84A-3k55A:
2.1
4f84A-3k55A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE


(Cytophaga
hutchinsonii)
PF01494
(FAD_binding_3)
5 GLY A  17
GLY A  14
VAL A  19
THR A  18
VAL A  31
None
FAD  A 501 ( 3.8A)
None
None
None
1.16A 4f84A-3nixA:
2.4
4f84A-3nixA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ol2 SEMAPHORIN-4D

(Homo sapiens)
PF00047
(ig)
PF01403
(Sema)
PF01437
(PSI)
5 GLY A 490
GLY A 494
VAL A 473
LEU A 466
VAL A 487
None
1.23A 4f84A-3ol2A:
undetectable
4f84A-3ol2A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pu2 UNCHARACTERIZED
PROTEIN


(Rhodobacter
sphaeroides)
PF08327
(AHSA1)
5 GLY A  90
THR A  89
LEU A  88
SER A 104
VAL A 118
None
1.18A 4f84A-3pu2A:
undetectable
4f84A-3pu2A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfk UNCHARACTERIZED
PROTEIN


(Staphylococcus
aureus)
PF00149
(Metallophos)
PF02872
(5_nucleotid_C)
5 GLY A 252
GLY A 249
VAL A 255
THR A 254
GLN A 235
None
1.15A 4f84A-3qfkA:
2.5
4f84A-3qfkA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qha PUTATIVE
OXIDOREDUCTASE


(Mycobacterium
avium)
PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11)
5 GLY A  18
GLY A  23
VAL A  74
THR A  73
VAL A  61
None
1.02A 4f84A-3qhaA:
5.1
4f84A-3qhaA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qha PUTATIVE
OXIDOREDUCTASE


(Mycobacterium
avium)
PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11)
5 GLY A  18
GLY A  23
VAL A  74
THR A  73
VAL A  64
None
0.92A 4f84A-3qhaA:
5.1
4f84A-3qhaA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qj4 RENALASE

(Homo sapiens)
PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8)
5 GLY A   8
GLY A  13
THR A 160
LEU A 159
VAL A 132
FAD  A 401 (-3.3A)
None
None
None
FAD  A 401 (-4.1A)
1.18A 4f84A-3qj4A:
2.4
4f84A-3qj4A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh0 ARSENATE REDUCTASE

(Corynebacterium
glutamicum)
PF01451
(LMWPc)
5 GLY A  13
GLY A  10
LEU A  80
MET A  17
VAL A 115
OCS  A   8 ( 4.5A)
OCS  A   8 ( 4.1A)
None
None
None
1.12A 4f84A-3rh0A:
2.4
4f84A-3rh0A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE


(Pseudomonas
aeruginosa)
PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C)
5 GLY A 261
VAL A 265
THR A 264
LEU A 263
ASN A 160
UD1  A 366 (-3.2A)
None
UD1  A 366 (-2.8A)
UD1  A 366 (-3.8A)
None
1.01A 4f84A-3s2uA:
4.0
4f84A-3s2uA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0f BETA-KETOACYL
SYNTHASE


(Brucella
abortus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLY A 336
GLY A 105
THR A 163
ASN A 165
SER A 334
None
07L  A 411 (-3.3A)
None
None
None
1.06A 4f84A-3u0fA:
undetectable
4f84A-3u0fA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyu ANTIFREEZE PROTEIN

(Leucosporidium
sp. AY30)
PF11999
(DUF3494)
5 GLY A 169
GLY A 194
VAL A 197
GLN A 192
SER A 145
None
1.22A 4f84A-3uyuA:
undetectable
4f84A-3uyuA:
20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E


(Streptomyces
coelicolor)
PF08241
(Methyltransf_11)
11 GLY A 105
GLY A 107
VAL A 126
THR A 127
LEU A 128
GLN A 132
ASN A 155
MET A 156
SER A 174
TYR A 177
VAL A 178
SAH  A 302 (-3.4A)
SAH  A 302 (-3.3A)
SAH  A 302 ( 4.9A)
SAH  A 302 (-4.0A)
SAH  A 302 (-4.1A)
SAH  A 302 (-3.1A)
GOL  A 304 ( 3.4A)
SAH  A 302 (-3.9A)
SAH  A 302 (-4.5A)
SAH  A 302 ( 3.9A)
None
0.46A 4f84A-3vc1A:
39.4
4f84A-3vc1A:
85.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgk CELL DIVISION
PROTEIN FTSZ


(Staphylococcus
aureus)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
5 GLY A 110
GLY A 106
THR A 111
SER A 103
VAL A 101
GDP  A 400 (-3.4A)
GDP  A 400 ( 4.7A)
None
None
None
1.09A 4f84A-3wgkA:
3.5
4f84A-3wgkA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9i CS6 FIMBRIAL SUBUNIT
A, CS6 FIMBRIAL
SUBUNIT B


(Escherichia
coli)
no annotation 5 GLY A 126
VAL A 125
THR A  50
TYR A 128
VAL A  46
None
1.22A 4f84A-4b9iA:
undetectable
4f84A-4b9iA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE


(Trypanosoma
cruzi)
PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8)
5 GLY A  13
GLY A  15
VAL A 263
THR A 262
VAL A  10
FDA  A 502 (-3.3A)
FDA  A 502 (-3.2A)
FDA  A 502 (-3.9A)
FDA  A 502 ( 4.4A)
None
1.19A 4f84A-4dshA:
undetectable
4f84A-4dshA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 GLY A 172
VAL A 176
THR A 175
LEU A 174
VAL A 333
CL  A 419 (-3.9A)
None
None
None
None
1.11A 4f84A-4ej6A:
6.8
4f84A-4ej6A:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E


(Linum
nodiflorum)
PF00891
(Methyltransf_2)
PF08100
(Dimerisation)
5 GLY A 208
GLY A 210
ASN A 252
MET A 253
TYR A 162
SAH  A 401 (-3.6A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-3.3A)
SAH  A 401 (-4.1A)
SAH  A 401 ( 3.6A)
1.10A 4f84A-4eviA:
13.2
4f84A-4eviA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E


(Linum
nodiflorum)
PF00891
(Methyltransf_2)
PF08100
(Dimerisation)
5 GLY A 208
GLY A 210
LEU A 232
ASN A 252
MET A 253
SAH  A 401 (-3.6A)
SAH  A 401 ( 3.8A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-3.3A)
SAH  A 401 (-4.1A)
0.65A 4f84A-4eviA:
13.2
4f84A-4eviA:
26.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E


(Streptomyces
lasaliensis)
PF02353
(CMAS)
12 HIS A  57
GLY A 113
GLY A 115
VAL A 134
THR A 135
LEU A 136
GLN A 140
ASN A 163
MET A 164
SER A 182
TYR A 185
VAL A 186
None
0.27A 4f84A-4f85A:
42.8
4f84A-4f85A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fz2 TRNA INTRON
ENDONUCLEASE


(Candidatus
Micrarchaeum
acidiphilum)
PF01974
(tRNA_int_endo)
5 GLY A 128
VAL A 138
THR A 137
LEU A 171
ASN A 169
None
1.24A 4f84A-4fz2A:
undetectable
4f84A-4fz2A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE


(Photorhabdus
laumondii)
PF01494
(FAD_binding_3)
5 GLY A  12
GLY A   9
THR A  13
LEU A 121
VAL A  26
None
FAD  A 501 (-3.2A)
None
None
None
1.04A 4f84A-4hb9A:
2.9
4f84A-4hb9A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxk OXIDOREDUCTASE

(Rhodococcus
opacus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 GLY A 162
GLY A 159
VAL A 164
THR A 163
VAL A 176
None
1.03A 4f84A-4jxkA:
7.1
4f84A-4jxkA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqk NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE


(Salmonella
enterica)
PF02277
(DBI_PRT)
5 GLY A 166
VAL A 167
THR A 168
LEU A 258
GLN A  57
None
1.17A 4f84A-4kqkA:
undetectable
4f84A-4kqkA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1r CELLULASE 5

(soil metagenome)
PF00150
(Cellulase)
5 GLY A  61
GLY A  66
VAL A  62
ASN A 131
SER A  29
None
None
None
TRS  A 301 (-3.3A)
None
1.16A 4f84A-4m1rA:
undetectable
4f84A-4m1rA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng4 PHOSPHOGLYCERATE
KINASE


(Coxiella
burnetii)
PF00162
(PGK)
5 GLY A 347
GLY A 349
THR A 351
LEU A 355
SER A 368
None
ADP  A 402 (-4.0A)
ADP  A 402 (-3.5A)
None
None
1.25A 4f84A-4ng4A:
2.8
4f84A-4ng4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE


(Homo sapiens)
PF01112
(Asparaginase_2)
5 GLY A 167
GLY A 220
VAL A 169
THR A 168
VAL A  68
None
1.08A 4f84A-4o0eA:
undetectable
4f84A-4o0eA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozi T-CELL RECEPTOR, S2,
BETA CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
5 GLY F 107
GLY F 110
VAL F 108
THR F 113
VAL F   4
None
1.21A 4f84A-4oziF:
undetectable
4f84A-4oziF:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A


(Pseudomonas
mendocina)
PF02332
(Phenol_Hydrox)
5 GLY A 274
THR A 273
LEU A 272
TYR A 331
VAL A 335
None
1.12A 4f84A-4p1cA:
undetectable
4f84A-4p1cA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS


(Homo sapiens)
PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N)
5 GLY A1202
GLY A1189
VAL A1182
ASN A1357
MET A1358
None
1.17A 4f84A-4pj3A:
2.7
4f84A-4pj3A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pne METHYLTRANSFERASE-LI
KE PROTEIN


(Saccharopolyspora
spinosa)
PF08241
(Methyltransf_11)
5 GLY A  80
GLY A  82
THR A 102
GLN A 107
SER A 149
SAH  A 301 (-2.7A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.1A)
SAH  A 301 (-4.7A)
0.48A 4f84A-4pneA:
25.8
4f84A-4pneA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE


(Methylovorus
sp. MP688)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 GLY A  12
GLY A  17
THR A 265
LEU A 264
VAL A 233
FAD  A 700 (-3.2A)
None
None
None
FAD  A 700 (-4.0A)
1.21A 4f84A-4udrA:
2.2
4f84A-4udrA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydl HEAVY CHAIN OF
ANTIBODY
C38-VRC18.02
LIGHT CHAIN OF
ANTIBODY
C38-VRC18.02


(Homo sapiens;
Homo sapiens)
no annotation
no annotation
5 HIS H  35
GLY H  95
LEU L  46
GLN L  89
VAL H   2
None
None
None
None
PCA  H   1 ( 3.3A)
1.17A 4f84A-4ydlH:
undetectable
4f84A-4ydlH:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avo HOMOSERINE
DEHYDROGENASE


(Sulfurisphaera
tokodaii)
PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3)
5 GLY A 282
GLY A 280
VAL A 263
ASN A 155
SER A 131
None
1.21A 4f84A-5avoA:
undetectable
4f84A-5avoA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6h ADENINE
PHOSPHORIBOSYLTRANSF
ERASE


(Yersinia
pseudotuberculosis)
PF00156
(Pribosyltran)
5 GLY A  66
GLY A  71
VAL A  89
THR A  67
VAL A 126
None
NA  A 502 ( 4.7A)
None
None
None
1.20A 4f84A-5b6hA:
undetectable
4f84A-5b6hA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2


(Rickettsia
typhi)
PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31)
5 GLY A  51
GLY A  53
LEU A  75
GLN A  79
VAL A 124
None
1.09A 4f84A-5dooA:
15.3
4f84A-5dooA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ff5 PAAA

(Pantoea
agglomerans)
PF00899
(ThiF)
5 GLY A 144
GLY A 141
THR A 145
LEU A 177
GLN A 175
None
SO4  A 401 ( 3.7A)
None
None
SO4  A 401 (-3.7A)
1.23A 4f84A-5ff5A:
4.8
4f84A-5ff5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ff5 PAAA

(Pantoea
agglomerans)
PF00899
(ThiF)
5 GLY A 144
GLY A 142
THR A 145
LEU A 177
GLN A 175
None
SO4  A 401 (-3.6A)
None
None
SO4  A 401 (-3.7A)
1.24A 4f84A-5ff5A:
4.8
4f84A-5ff5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145


(Bacillus sp.
(in: Bacteria))
PF00082
(Peptidase_S8)
5 GLY A  73
GLY A  71
THR A  36
LEU A 106
GLN A  70
None
1.10A 4f84A-5ffnA:
undetectable
4f84A-5ffnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gm2 O-METHYLRANSFERASE

(Streptomyces
blastmyceticus)
PF08241
(Methyltransf_11)
5 GLY A  85
GLY A  87
VAL A 106
GLN A 112
SER A 154
SAH  A 301 (-3.2A)
SAH  A 301 (-3.1A)
None
SAH  A 301 (-2.6A)
SAH  A 301 (-4.4A)
0.40A 4f84A-5gm2A:
25.8
4f84A-5gm2A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE


(Corynebacterium
glutamicum)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 GLY A 129
GLY A  93
VAL A  82
GLN A 113
VAL A 101
None
AKG  A 502 (-3.4A)
None
AKG  A 502 (-2.9A)
None
1.15A 4f84A-5ijzA:
3.9
4f84A-5ijzA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE


(Rhizobium
leguminosarum)
PF00920
(ILVD_EDD)
5 GLY A 274
GLY A 380
THR A 308
LEU A 376
ASN A 311
None
1.18A 4f84A-5j84A:
undetectable
4f84A-5j84A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k94 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PROTEIN
TRANSLOCASE SUBUNIT
SECA,MALTOSE-BINDING
PERIPLASMIC PROTEIN


(Escherichia
coli)
PF01043
(SecA_PP_bind)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8)
5 GLY A 278
GLY A 261
THR A 275
GLN A 249
VAL A 310
None
1.19A 4f84A-5k94A:
undetectable
4f84A-5k94A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4u FLAGELLIN

(Pyrococcus
furiosus)
PF01917
(Arch_flagellin)
5 GLY A 166
GLY A 168
VAL A 171
ASN A  98
TYR A  70
None
1.24A 4f84A-5o4uA:
undetectable
4f84A-5o4uA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttk AMINE OXIDASE

(Pseudomonas
putida)
PF01593
(Amino_oxidase)
5 GLY A  60
GLY A  62
VAL A 308
THR A 307
VAL A  57
FAD  A 501 (-3.1A)
FAD  A 501 (-3.5A)
FAD  A 501 (-4.1A)
None
None
1.23A 4f84A-5ttkA:
undetectable
4f84A-5ttkA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5unn NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE


(Sinorhizobium
meliloti)
PF02826
(2-Hacid_dh_C)
5 GLY A 143
GLY A 167
VAL A 197
LEU A 158
VAL A 140
None
1.13A 4f84A-5unnA:
6.8
4f84A-5unnA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvi GLUTAMATE
DEHYDROGENASE


(Aspergillus
niger)
no annotation 5 GLY A 115
GLY A  79
VAL A  68
GLN A  99
VAL A  87
None
1.18A 4f84A-5xviA:
5.1
4f84A-5xviA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MONOBODY YSX1

(synthetic
construct)
no annotation 5 GLY B  75
GLY B  80
VAL B  29
TYR B  73
VAL B  72
None
1.23A 4f84A-6apxB:
undetectable
4f84A-6apxB:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6at7 PHENYLALANINE
AMMONIA-LYASE


(Sorghum bicolor)
no annotation 5 GLY A 481
GLY A 252
THR A 188
ASN A 478
SER A 484
None
None
MDO  A 190 ( 4.4A)
None
None
1.18A 4f84A-6at7A:
undetectable
4f84A-6at7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE


(Escherichia
coli)
no annotation 5 GLY A 175
GLY A 177
VAL A 196
THR A 197
GLN A 202
None
0.48A 4f84A-6bqcA:
23.7
4f84A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cia ALDO/KETO REDUCTASE

(Klebsiella
pneumoniae)
no annotation 5 GLY A 158
THR A 155
LEU A 120
GLN A 121
VAL A 141
None
1.23A 4f84A-6ciaA:
undetectable
4f84A-6ciaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cr0 (S)-6-HYDROXYNICOTIN
E OXIDASE


(Shinella sp.
HZN7)
no annotation 5 GLY A  12
GLY A  17
THR A 259
LEU A 258
VAL A 231
FAD  A 507 (-3.4A)
None
None
None
FAD  A 507 (-3.8A)
1.20A 4f84A-6cr0A:
undetectable
4f84A-6cr0A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f45 -

(-)
no annotation 5 GLY D 158
GLY D 156
VAL D 121
SER D 218
TYR D 204
None
1.15A 4f84A-6f45D:
undetectable
4f84A-6f45D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gkv COCLAURINE
N-METHYLTRANSFERASE


(Coptis japonica)
no annotation 5 GLY A 137
GLY A 139
VAL A 159
THR A 160
GLN A 165
SAH  A 501 (-3.5A)
SAH  A 501 (-3.1A)
None
SAH  A 501 ( 4.8A)
SAH  A 501 (-2.7A)
0.51A 4f84A-6gkvA:
20.0
4f84A-6gkvA:
undetectable