SIMILAR PATTERNS OF AMINO ACIDS FOR 4F4D_B_CHDB505_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9n U2A'

(Homo sapiens)
PF14580
(LRR_9)
5 LEU A 109
LEU A 118
LEU A 145
ILE A  79
VAL A 125
None
1.24A 4f4dB-1a9nA:
undetectable
4f4dB-1a9nA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1djp GLUTAMINASE-ASPARAGI
NASE


(Pseudomonas sp.
7A)
PF00710
(Asparaginase)
5 LEU A1110
LEU A1075
ILE A1094
THR A1102
VAL A1062
None
1.23A 4f4dB-1djpA:
4.4
4f4dB-1djpA:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae)
PF00762
(Ferrochelatase)
7 LEU A  68
ARG A  87
LYS A  90
SER A 169
HIS A 235
VAL A 277
TRP A 282
None
1.40A 4f4dB-1lbqA:
48.3
4f4dB-1lbqA:
49.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae)
PF00762
(Ferrochelatase)
7 LEU A  68
ARG A  87
LYS A  90
THR A 170
HIS A 235
VAL A 277
TRP A 282
None
1.21A 4f4dB-1lbqA:
48.3
4f4dB-1lbqA:
49.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae)
PF00762
(Ferrochelatase)
9 MET A  46
LEU A  59
ARG A  87
LYS A  90
ILE A  91
SER A 169
HIS A 235
VAL A 277
TRP A 282
None
0.90A 4f4dB-1lbqA:
48.3
4f4dB-1lbqA:
49.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae)
PF00762
(Ferrochelatase)
9 MET A  46
LEU A  59
ARG A  87
LYS A  90
ILE A  91
THR A 170
HIS A 235
VAL A 277
TRP A 282
None
0.73A 4f4dB-1lbqA:
48.3
4f4dB-1lbqA:
49.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae)
PF00762
(Ferrochelatase)
9 MET A  46
LEU A  59
LEU A  62
LYS A  90
ILE A  91
SER A 169
HIS A 235
VAL A 277
TRP A 282
None
0.88A 4f4dB-1lbqA:
48.3
4f4dB-1lbqA:
49.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae)
PF00762
(Ferrochelatase)
9 MET A  46
LEU A  59
LEU A  62
LYS A  90
ILE A  91
THR A 170
HIS A 235
VAL A 277
TRP A 282
None
0.70A 4f4dB-1lbqA:
48.3
4f4dB-1lbqA:
49.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE


(Lactococcus
lactis)
PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N)
5 LEU A 637
LEU A 680
ILE A 727
THR A 472
HIS A 735
None
1.12A 4f4dB-1lnsA:
1.9
4f4dB-1lnsA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens)
PF13855
(LRR_8)
5 LEU A  83
LEU A 107
LEU A 129
ILE A  62
VAL A  72
None
1.09A 4f4dB-1oznA:
undetectable
4f4dB-1oznA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens)
PF13855
(LRR_8)
5 LEU A 112
LEU A 137
LEU A 159
ILE A  96
THR A 173
None
1.22A 4f4dB-1oznA:
undetectable
4f4dB-1oznA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum)
PF00733
(Asn_synthase)
PF09147
(DUF1933)
5 LEU A  92
LEU A  88
LEU A  84
ARG A  91
THR A  63
None
1.06A 4f4dB-1q15A:
2.2
4f4dB-1q15A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA


(Geobacillus
stearothermophilus)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
5 LEU A 617
LEU A 577
LEU A 564
ILE A 321
VAL A 299
None
1.20A 4f4dB-1qhgA:
2.4
4f4dB-1qhgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))
PROTEIN (PCRA
(SUBUNIT))


(Geobacillus
stearothermophilus;
Geobacillus
stearothermophilus)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
PF13361
(UvrD_C)
5 LEU D 617
LEU D 577
LEU D 564
ILE B 321
VAL B 299
None
1.18A 4f4dB-1qhhD:
undetectable
4f4dB-1qhhD:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE


(Cryptococcus
neoformans)
PF00475
(IGPD)
5 LEU A 144
LEU A 145
LEU A 126
SER A 160
VAL A 133
None
1.14A 4f4dB-1rhyA:
undetectable
4f4dB-1rhyA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 41 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
PF00004
(AAA)
PF08542
(Rep_fac_C)
PF13177
(DNA_pol3_delta2)
5 LEU D 347
LEU D 343
LEU D 333
ILE D 271
SER E 175
None
1.13A 4f4dB-1sxjD:
undetectable
4f4dB-1sxjD:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbr CONSERVED
HYPOTHETICAL PROTEIN


(Porphyromonas
gingivalis)
PF04371
(PAD_porph)
5 LEU A 281
LEU A 328
LEU A 321
ILE A 283
TRP A  20
None
1.18A 4f4dB-1zbrA:
undetectable
4f4dB-1zbrA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaa ALPHA-AMYLASE

(Aspergillus
niger)
PF00128
(Alpha-amylase)
PF09260
(DUF1966)
5 LEU A 100
LEU A 103
LEU A 107
ILE A  65
TRP A   6
None
0.94A 4f4dB-2aaaA:
undetectable
4f4dB-2aaaA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayx SENSOR KINASE
PROTEIN RCSC


(Escherichia
coli)
PF00072
(Response_reg)
PF09456
(RcsC)
5 LEU A 936
LEU A 847
ILE A 900
SER A 846
VAL A 927
None
1.25A 4f4dB-2ayxA:
3.1
4f4dB-2ayxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkk CYTOCHROME P450

(Streptomyces
coelicolor)
PF00067
(p450)
6 LEU A 266
LEU A 260
LEU A 257
ARG A 263
ILE A 337
TRP A 391
None
1.29A 4f4dB-2dkkA:
undetectable
4f4dB-2dkkA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8b PROBABLE
MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A


(Aquifex
aeolicus)
PF12804
(NTP_transf_3)
5 LEU A 163
LEU A 164
LEU A 134
ILE A 149
VAL A 102
None
1.24A 4f4dB-2e8bA:
2.3
4f4dB-2e8bA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv2 RCD1 REQUIRED FOR
CELL
DIFFERENTIATION1
HOMOLOG


(Homo sapiens)
PF04078
(Rcd1)
5 LEU A  51
LEU A  50
LEU A  23
ILE A  99
SER A  27
None
1.25A 4f4dB-2fv2A:
undetectable
4f4dB-2fv2A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE


(Aquifex
aeolicus)
PF03331
(LpxC)
5 LEU A 250
LEU A 247
LEU A 243
THR A 156
VAL A 138
None
0.98A 4f4dB-2go4A:
undetectable
4f4dB-2go4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Trypanosoma
cruzi)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
5 LEU A 420
LEU A 456
LEU A 274
VAL A 292
TRP A 289
None
1.23A 4f4dB-2h2qA:
2.2
4f4dB-2h2qA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk0 D-PSICOSE
3-EPIMERASE


(Agrobacterium
tumefaciens)
PF01261
(AP_endonuc_2)
5 LEU A  62
LEU A  99
LEU A  48
ILE A  33
SER A  44
LEU  A  62 ( 0.6A)
LEU  A  99 ( 0.6A)
LEU  A  48 ( 0.6A)
ILE  A  33 ( 0.7A)
SER  A  44 ( 0.0A)
1.17A 4f4dB-2hk0A:
undetectable
4f4dB-2hk0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgr YEGS

(Escherichia
coli)
PF00781
(DAGK_cat)
5 LEU A  91
LEU A  93
SER A  15
THR A  16
VAL A  73
None
1.24A 4f4dB-2jgrA:
5.9
4f4dB-2jgrA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes)
PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
5 LEU A 404
LEU A 401
ILE A 385
SER A 374
VAL A 357
None
1.25A 4f4dB-2omvA:
undetectable
4f4dB-2omvA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdf PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE


(Escherichia
coli)
PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N)
5 LEU A 513
LEU A 514
LEU A 482
SER A 478
THR A 558
None
1.20A 4f4dB-2xdfA:
undetectable
4f4dB-2xdfA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18

(Monosiga
brevicollis)
PF00995
(Sec1)
5 LEU A 171
LEU A 168
LEU A 164
THR A 191
VAL A 575
None
1.22A 4f4dB-2xheA:
3.4
4f4dB-2xheA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhg CELLULOSE-BINDING
PROTEIN


(Saccharophagus
degradans)
PF07632
(DUF1593)
5 LEU A 691
LEU A 669
ILE A 653
THR A 663
VAL A 634
None
1.22A 4f4dB-2yhgA:
3.1
4f4dB-2yhgA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus)
PF00067
(p450)
5 LEU A 240
LEU A 241
LEU A 215
ILE A  96
SER A 112
HEM  A 413 ( 4.5A)
HEM  A 413 (-4.5A)
None
HEM  A 413 (-4.0A)
None
1.24A 4f4dB-2zbzA:
undetectable
4f4dB-2zbzA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74


(Saccharomyces
cerevisiae)
PF05719
(GPP34)
5 LEU A 265
LEU A 269
LEU A 272
ILE A 256
VAL A 306
None
1.22A 4f4dB-2ziiA:
undetectable
4f4dB-2ziiA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvw PROLIFERATING CELL
NUCLEAR ANTIGEN 2


(Arabidopsis
thaliana)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
5 LEU A  79
LEU A  16
LEU A  72
ILE A  88
VAL A  99
None
0.98A 4f4dB-2zvwA:
undetectable
4f4dB-2zvwA:
19.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens)
PF00762
(Ferrochelatase)
9 LEU A  89
LEU A  92
LEU A  98
ILE A 119
SER A 197
THR A 198
HIS A 263
VAL A 305
TRP A 310
None
CHD  A   1 (-4.8A)
CHD  A   1 (-4.3A)
None
CHD  A   1 (-3.0A)
None
CHD  A   1 (-4.3A)
CHD  A   1 ( 4.9A)
CHD  A   2 (-4.7A)
0.45A 4f4dB-3aqiA:
60.7
4f4dB-3aqiA:
99.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens)
PF00762
(Ferrochelatase)
8 LEU A  89
LEU A  92
LEU A  98
LYS A 118
ILE A 119
SER A 197
VAL A 305
TRP A 310
None
CHD  A   1 (-4.8A)
CHD  A   1 (-4.3A)
None
None
CHD  A   1 (-3.0A)
CHD  A   1 ( 4.9A)
CHD  A   2 (-4.7A)
0.93A 4f4dB-3aqiA:
60.7
4f4dB-3aqiA:
99.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE


(Geobacillus
stearothermophilus)
PF00115
(COX1)
5 LEU A 473
LEU A 469
ILE A 374
SER A 537
THR A 534
None
1.25A 4f4dB-3ayfA:
undetectable
4f4dB-3ayfA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwk PENICILLIN-BINDING
PROTEIN 2


(Staphylococcus
aureus)
PF00905
(Transpeptidase)
PF00912
(Transgly)
5 LEU A 404
LEU A 400
LEU A 508
ILE A 490
SER A 504
None
0.92A 4f4dB-3dwkA:
undetectable
4f4dB-3dwkA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egl DEGV FAMILY PROTEIN

(Corynebacterium
glutamicum)
PF02645
(DegV)
5 LEU A 221
LEU A 192
LEU A 195
ILE A 209
VAL A 205
None
MLY  A 191 ( 4.5A)
MLY  A 191 ( 3.7A)
None
None
1.25A 4f4dB-3eglA:
2.5
4f4dB-3eglA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2


(Schizosaccharomyces
pombe)
PF03159
(XRN_N)
5 LEU A 691
LEU A 688
LEU A 743
ILE A 699
SER A 748
None
1.11A 4f4dB-3fqdA:
2.7
4f4dB-3fqdA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE


(Salmonella
enterica)
PF00152
(tRNA-synt_2)
5 LEU A 134
LEU A 127
ILE A  26
SER A 295
VAL A  35
None
1.24A 4f4dB-3g1zA:
undetectable
4f4dB-3g1zA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7u ALDO-KETO REDUCTASE

(Arabidopsis
thaliana)
PF00248
(Aldo_ket_red)
5 LEU A  65
LEU A  62
LEU A 103
SER A  80
THR A  79
None
1.07A 4f4dB-3h7uA:
undetectable
4f4dB-3h7uA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7u ALDO-KETO REDUCTASE

(Arabidopsis
thaliana)
PF00248
(Aldo_ket_red)
5 LEU A  65
LEU A 103
SER A  80
THR A  79
VAL A  31
None
1.19A 4f4dB-3h7uA:
undetectable
4f4dB-3h7uA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htv D-ALLOSE KINASE

(Escherichia
coli)
PF00480
(ROK)
5 LEU A 106
LEU A 102
LEU A  98
ILE A  53
VAL A  40
None
1.16A 4f4dB-3htvA:
undetectable
4f4dB-3htvA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv0 HET-C2

(Podospora
anserina)
PF08718
(GLTP)
5 MET A  67
LEU A 197
ILE A  88
THR A  49
VAL A  26
None
MLY  A 198 ( 4.3A)
None
MLY  A  64 ( 4.3A)
None
1.19A 4f4dB-3kv0A:
undetectable
4f4dB-3kv0A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll9 ISOPENTENYL
PHOSPHATE KINASE


(Methanothermobacter
thermautotrophicus)
PF00696
(AA_kinase)
5 LEU A 160
ILE A 155
SER A   9
THR A  12
HIS A  52
None
None
ADP  A 267 (-2.7A)
None
None
1.23A 4f4dB-3ll9A:
3.1
4f4dB-3ll9A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Pectobacterium
atrosepticum)
PF00155
(Aminotran_1_2)
5 LEU A 323
LEU A 320
LEU A 317
ILE A 394
SER A 330
None
1.03A 4f4dB-3ly1A:
undetectable
4f4dB-3ly1A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA


(Escherichia
coli)
PF00873
(ACR_tran)
5 MET A 696
LEU A 840
ILE A 826
SER A 855
THR A 854
None
1.24A 4f4dB-3ne5A:
undetectable
4f4dB-3ne5A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyq MALONYL-COA LIGASE

(Streptomyces
coelicolor)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 LEU A 160
LEU A 167
ILE A 155
SER A 294
THR A 293
None
1.07A 4f4dB-3nyqA:
undetectable
4f4dB-3nyqA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2j DIPEPTIDASE

(Streptomyces
coelicolor)
PF01244
(Peptidase_M19)
6 LEU A 357
LEU A 354
LEU A 345
ILE A 317
SER A   3
VAL A 296
None
1.30A 4f4dB-3s2jA:
undetectable
4f4dB-3s2jA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqz PUTATIVE
HYDROXYMETHYLGLUTARY
L-COA SYNTHASE


(Streptococcus
mutans)
PF00195
(Chal_sti_synt_N)
PF08540
(HMG_CoA_synt_C)
5 LEU A 290
LEU A 287
LEU A 284
ILE A 168
THR A  11
None
None
None
None
GOL  A 392 (-4.2A)
1.24A 4f4dB-3sqzA:
undetectable
4f4dB-3sqzA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CRISPR SYSTEM CMR
SUBUNIT CMR5


(Archaeoglobus
fulgidus)
PF09701
(Cas_Cmr5)
5 LEU F 111
LEU F  98
LEU F  94
ILE F 131
THR F  54
None
1.06A 4f4dB-3x1lF:
undetectable
4f4dB-3x1lF:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3


(Drosophila
melanogaster)
no annotation 5 LEU A 599
LEU A 596
LEU A 593
ILE A 554
THR A 648
None
0.95A 4f4dB-4bwpA:
undetectable
4f4dB-4bwpA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
5 LEU A 241
LEU A 245
LEU A 137
SER A 132
THR A 131
None
1.17A 4f4dB-4bziA:
3.2
4f4dB-4bziA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA


(Streptococcus
pneumoniae)
PF13306
(LRR_5)
5 LEU A 342
LEU A 365
LEU A 386
ILE A 322
VAL A 358
None
1.23A 4f4dB-4cp6A:
undetectable
4f4dB-4cp6A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cs5 PROLIFERATING CELL
NUCLEAR ANTIGEN


(Litopenaeus
vannamei)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
5 LEU A  79
LEU A  16
LEU A  72
ILE A  88
VAL A  99
None
1.12A 4f4dB-4cs5A:
undetectable
4f4dB-4cs5A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493


(Thermus
thermophilus)
PF02475
(Met_10)
5 LEU A 305
LEU A 331
ARG A 303
SER A 328
THR A 290
None
1.13A 4f4dB-4dmgA:
undetectable
4f4dB-4dmgA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE


(Salmonella
enterica)
PF12710
(HAD)
5 LEU A 211
LEU A 141
SER A 113
THR A 117
VAL A 152
None
1.18A 4f4dB-4ezeA:
undetectable
4f4dB-4ezeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN


(Bacteroides
ovatus)
PF13306
(LRR_5)
5 LEU A 298
LEU A 319
LEU A 342
ILE A 278
VAL A 308
None
0.99A 4f4dB-4fs7A:
undetectable
4f4dB-4fs7A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwi ABC-TYPE
DIPEPTIDE/OLIGOPEPTI
DE/NICKEL TRANSPORT
SYSTEM, ATPASE
COMPONENT


(Caldanaerobacter
subterraneus)
PF00005
(ABC_tran)
PF08352
(oligo_HPY)
5 MET B 139
LEU B 197
LEU B 200
ILE B 193
VAL B  95
None
1.18A 4f4dB-4fwiB:
undetectable
4f4dB-4fwiB:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxr PROTEIN TOLL

(Drosophila
melanogaster)
PF00560
(LRR_1)
PF01462
(LRRNT)
PF13306
(LRR_5)
PF13855
(LRR_8)
5 LEU A 349
LEU A 354
ILE A 344
SER A 332
THR A 309
None
1.11A 4f4dB-4lxrA:
undetectable
4f4dB-4lxrA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mag SIALIC ACID BINDING
PROTEIN


(Vibrio cholerae)
PF03480
(DctP)
5 LEU A  27
LEU A  37
LEU A  39
ILE A 232
VAL A 214
None
1.18A 4f4dB-4magA:
undetectable
4f4dB-4magA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mct KILLER PROTEIN

(Proteus
vulgaris)
PF05015
(HigB-like_toxin)
5 LEU B  86
LEU B  10
ILE B   2
SER B  20
THR B  19
None
1.11A 4f4dB-4mctB:
undetectable
4f4dB-4mctB:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8)
5 LEU B 121
LEU B 145
LEU B 166
SER B 185
THR B 161
None
1.20A 4f4dB-4mn8B:
undetectable
4f4dB-4mn8B:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE


(Thermomonospora
curvata)
PF01580
(FtsK_SpoIIIE)
5 LEU A1232
LEU A1240
LEU A1208
ILE A1259
VAL A1212
None
1.25A 4f4dB-4nh0A:
undetectable
4f4dB-4nh0A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovd PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE


(Atopobium
parvulum)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
5 LEU A 296
LEU A 541
ILE A 432
SER A 551
VAL A 306
None
1.14A 4f4dB-4ovdA:
undetectable
4f4dB-4ovdA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p42 EXTENDED
SYNAPTOTAGMIN-2


(Homo sapiens)
PF00168
(C2)
PF17047
(SMP_LBD)
5 LEU A 430
LEU A 369
ILE A 390
SER A 407
TRP A 460
None
1.24A 4f4dB-4p42A:
undetectable
4f4dB-4p42A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbc D-AMINO ACID
AMINOTRANSFERASE


(Burkholderia
cenocepacia)
PF01063
(Aminotran_4)
5 LEU A  71
LEU A  74
LEU A  78
ILE A  96
THR A 119
None
1.14A 4f4dB-4pbcA:
undetectable
4f4dB-4pbcA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN


(Legionella
pneumophila)
PF13855
(LRR_8)
5 LEU A 287
LEU A 311
LEU A 363
ILE A 277
THR A 356
None
1.19A 4f4dB-4q62A:
undetectable
4f4dB-4q62A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s38 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE


(Thermus
thermophilus)
PF04551
(GcpE)
5 LEU A 251
LEU A 247
LEU A 211
ILE A  24
THR A 231
None
1.10A 4f4dB-4s38A:
undetectable
4f4dB-4s38A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN


(Salmonella
enterica)
PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1)
5 LEU A 802
LEU A 767
LEU A 754
ILE A 793
VAL A 750
None
1.12A 4f4dB-4u48A:
undetectable
4f4dB-4u48A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpe CYTOKINESIS PROTEIN
2


(Saccharomyces
cerevisiae)
PF00611
(FCH)
5 LEU A  21
LEU A  20
LYS A 122
ILE A 123
SER A   4
None
1.23A 4f4dB-4wpeA:
undetectable
4f4dB-4wpeA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu4 HEMOGLOBIN

(Helogale
parvula)
PF00042
(Globin)
5 LEU A  73
LEU A  76
ILE A  10
SER A 138
THR A 137
None
1.04A 4f4dB-4yu4A:
undetectable
4f4dB-4yu4A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)


(Homo sapiens)
no annotation 5 LEU A 420
LEU A 450
LEU A 467
ILE A 407
THR A 462
None
None
None
None
GOL  A 504 (-3.5A)
1.10A 4f4dB-4z79A:
undetectable
4f4dB-4z79A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)


(Homo sapiens)
no annotation 5 LEU A 420
LEU A 450
LEU A 467
ILE A 407
THR A 462
None
1.08A 4f4dB-4z8gA:
undetectable
4f4dB-4z8gA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA


(Homo sapiens)
PF00626
(Gelsolin)
5 LEU G1420
LEU G1450
LEU G1467
ILE G1407
THR G1462
None
1.06A 4f4dB-4z94G:
2.4
4f4dB-4z94G:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zad FDC1

(Candida
dubliniensis)
PF01977
(UbiD)
5 LEU A 378
LEU A 381
ILE A 373
HIS A 348
VAL A 392
None
1.22A 4f4dB-4zadA:
undetectable
4f4dB-4zadA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoy SQT1

(Chaetomium
thermophilum)
PF00400
(WD40)
5 LEU A 328
LEU A 254
ILE A 325
THR A 285
VAL A 305
None
1.20A 4f4dB-4zoyA:
undetectable
4f4dB-4zoyA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE


(Neurospora
crassa)
PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1)
5 LEU A 267
LEU A 291
LEU A 320
ILE A 251
THR A 315
None
1.11A 4f4dB-4ztxA:
undetectable
4f4dB-4ztxA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE


(Catenulispora
acidiphila)
no annotation 5 LEU A 117
LEU A 128
ARG A 118
ILE A 158
THR A 175
None
1.24A 4f4dB-5bw4A:
2.2
4f4dB-5bw4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fms INTRAFLAGELLAR
TRANSPORT PROTEIN 52
HOMOLOG


(Mus musculus)
PF09822
(ABC_transp_aux)
5 LEU A  28
LEU A 225
ARG A  33
ILE A  38
SER A 231
None
1.22A 4f4dB-5fmsA:
undetectable
4f4dB-5fmsA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens)
PF00202
(Aminotran_3)
5 LEU A 428
LEU A 431
LEU A 435
ILE A 345
THR A 387
None
0.84A 4f4dB-5g4iA:
undetectable
4f4dB-5g4iA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens)
PF00202
(Aminotran_3)
5 LEU A 428
LEU A 431
LEU A 435
THR A 387
VAL A 362
None
1.09A 4f4dB-5g4iA:
undetectable
4f4dB-5g4iA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh1 ALDOSE REDUCTASE,
AKR4C7


(Zea mays)
PF00248
(Aldo_ket_red)
5 LEU A  62
LEU A  59
LEU A 100
SER A  77
THR A  76
None
1.08A 4f4dB-5jh1A:
undetectable
4f4dB-5jh1A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh1 ALDOSE REDUCTASE,
AKR4C7


(Zea mays)
PF00248
(Aldo_ket_red)
5 LEU A  62
LEU A 100
SER A  77
THR A  76
VAL A  28
None
1.23A 4f4dB-5jh1A:
undetectable
4f4dB-5jh1A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfn CHONDROADHERIN

(Homo sapiens)
PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8)
5 LEU A 251
LEU A 275
LEU A 295
ILE A 234
VAL A 267
None
0.98A 4f4dB-5lfnA:
undetectable
4f4dB-5lfnA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mea CELL DIVISION CYCLE
PROTEIN CDT1


(Saccharomyces
cerevisiae)
no annotation 5 LEU A 381
LEU A 340
LEU A 344
ILE A 430
SER A 348
None
1.17A 4f4dB-5meaA:
undetectable
4f4dB-5meaA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae)
PF13691
(Lactamase_B_4)
5 LEU A  84
LEU A  86
LEU A  93
ILE A  76
VAL A 104
None
1.13A 4f4dB-5mtzA:
undetectable
4f4dB-5mtzA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n72 WIPA

(Legionella
pneumophila)
no annotation 5 MET A 336
LEU A 362
LEU A 340
ILE A 275
VAL A 307
None
1.22A 4f4dB-5n72A:
undetectable
4f4dB-5n72A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0l RETICULON-4 RECEPTOR

(Mus musculus)
no annotation 5 LEU A  83
LEU A 107
LEU A 129
ILE A  62
VAL A  72
None
1.08A 4f4dB-5o0lA:
undetectable
4f4dB-5o0lA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0l RETICULON-4 RECEPTOR

(Mus musculus)
no annotation 5 LEU A 112
LEU A 137
LEU A 159
ILE A  96
THR A 173
None
1.22A 4f4dB-5o0lA:
undetectable
4f4dB-5o0lA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT


(Homo sapiens)
PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2)
5 LEU B 567
LEU B 597
ILE B 561
SER B 541
THR B 540
None
1.13A 4f4dB-5of4B:
undetectable
4f4dB-5of4B:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2


(Mycolicibacterium
smegmatis)
PF01261
(AP_endonuc_2)
5 LEU A 109
LEU A 106
ILE A  66
SER A  88
THR A  86
None
1.14A 4f4dB-5tnvA:
undetectable
4f4dB-5tnvA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr9 FERREDOXIN-NADP
REDUCTASE


(Neisseria
gonorrhoeae)
PF00175
(NAD_binding_1)
5 LEU A 136
LEU A 139
ILE A 132
SER A 184
THR A 150
None
0.85A 4f4dB-5tr9A:
3.7
4f4dB-5tr9A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6b PDZ
DOMAIN-CONTAINING
PROTEIN GIPC1


(Mus musculus)
PF00595
(PDZ)
5 LEU A 145
LEU A 198
LEU A 201
ILE A 157
VAL A 134
None
0.93A 4f4dB-5v6bA:
undetectable
4f4dB-5v6bA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu ENVELOPE
GLYCOPROTEIN GP160


(Human
immunodeficiency
virus 1)
no annotation 5 LEU G 285
LEU G 260
SER G 256
THR G 257
VAL G 101
None
1.06A 4f4dB-5wduG:
undetectable
4f4dB-5wduG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wml -

(-)
no annotation 5 LEU A 379
LEU A 375
ILE A 398
SER A 451
VAL A 430
None
1.25A 4f4dB-5wmlA:
2.7
4f4dB-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z24 PILUS ASSEMBLY
PROTEIN


(Lactobacillus
rhamnosus)
no annotation 5 LEU A 436
LEU A 431
ILE A 409
THR A 378
VAL A 397
None
1.18A 4f4dB-5z24A:
undetectable
4f4dB-5z24A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6an0 HISTIDINOL
DEHYDROGENASE


(Elizabethkingia
anophelis)
PF00815
(Histidinol_dh)
5 LEU A 236
ARG A 302
ILE A 304
SER A 340
THR A 339
None
1.12A 4f4dB-6an0A:
3.1
4f4dB-6an0A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6beg SCAFFOLD PROTEIN D13

(Vaccinia virus)
no annotation 5 LEU A 452
LEU A 443
ILE A 492
THR A 474
VAL A 246
None
1.13A 4f4dB-6begA:
undetectable
4f4dB-6begA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2


(Danio rerio)
no annotation 5 LEU A 197
LEU A 155
LEU A 160
LYS A 206
ILE A 207
None
1.23A 4f4dB-6d21A:
undetectable
4f4dB-6d21A:
undetectable