SIMILAR PATTERNS OF AMINO ACIDS FOR 4F4D_B_CHDB503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b06 PROTEIN (SUPEROXIDE
DISMUTASE)

(Sulfolobus
acidocaldarius) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 ILE A  86
PRO A 101
VAL A 195
TRP A 197
 None
 1.27A 4f4dB-1b06A:
undetectable		 4f4dB-1b06A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 350
ARG A 325
PRO A 316
VAL A 320
 None
 1.25A 4f4dB-1bxzA:
3.2		 4f4dB-1bxzA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		4 MET A 150
ILE A  80
ARG A  78
ARG A 112
 None
 1.28A 4f4dB-1eizA:
3.2		 4f4dB-1eizA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gv3 MANGANESE SUPEROXIDE
DISMUTASE

(Nostoc sp. PCC
7120) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 ILE A 119
PRO A 132
VAL A 225
TRP A 227
 None
 1.31A 4f4dB-1gv3A:
undetectable		 4f4dB-1gv3A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ha6 MACROPHAGE
INFLAMMATORY PROTEIN
3 ALPHA

(Mus musculus) 		PF00048
(IL8) 		4 ILE A  34
PRO A  14
VAL A  56
TRP A  55
 None
 1.22A 4f4dB-1ha6A:
undetectable		 4f4dB-1ha6A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg8 ENDOPOLYGALACTURONAS
E

(Fusarium
verticillioides) 		PF00295
(Glyco_hydro_28) 		4 ILE A 317
PRO A 372
VAL A 296
TRP A 336
 None
 1.02A 4f4dB-1hg8A:
undetectable		 4f4dB-1hg8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 ILE A 676
PRO A 609
VAL A 758
TRP A 598
 None
 1.05A 4f4dB-1hwwA:
0.0		 4f4dB-1hwwA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqr PHOTOLYASE

(Thermus
thermophilus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ARG A 412
ARG A 409
PRO A 396
VAL A 401
 None
 0.91A 4f4dB-1iqrA:
1.6		 4f4dB-1iqrA:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		5 ILE A  83
ARG A  87
PRO A 238
VAL A 277
TRP A 282
 None
 0.75A 4f4dB-1lbqA:
48.3		 4f4dB-1lbqA:
49.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B

([Haemophilus]
ducreyi) 		PF03372
(Exo_endo_phos) 		4 ILE B 149
PRO B  71
VAL B 104
TRP B  93
 None
 1.32A 4f4dB-1sr4B:
undetectable		 4f4dB-1sr4B:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svz SINGLE-CHAIN FV
FRAGMENT 1696

(Mus musculus) 		PF07686
(V-set) 		4 ILE A 147
PRO A  49
VAL A 224
TRP A 237
 None
 1.18A 4f4dB-1svzA:
undetectable		 4f4dB-1svzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugs NITRILE HYDRATASE
ALPHA SUBUNIT

(Pseudonocardia
thermophila) 		PF02979
(NHase_alpha) 		4 ILE A  85
PRO A 172
VAL A  60
TRP A  63
 None
 1.29A 4f4dB-1ugsA:
undetectable		 4f4dB-1ugsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uio ADENOSINE DEAMINASE

(Mus musculus) 		PF00962
(A_deaminase) 		4 ILE A  79
ARG A  76
VAL A 112
TRP A 161
 None
 1.12A 4f4dB-1uioA:
undetectable		 4f4dB-1uioA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujc PHOSPHOHISTIDINE
PHOSPHATASE SIXA

(Escherichia
coli) 		PF00300
(His_Phos_1) 		4 ARG A  21
PRO A 125
VAL A 112
MET A 127
 WO4  A 163 ( 4.3A)
None
None
None
 1.19A 4f4dB-1ujcA:
3.2		 4f4dB-1ujcA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		4 ILE A 213
ARG A 390
PRO A 405
VAL A 409
 None
 1.19A 4f4dB-1vrqA:
undetectable		 4f4dB-1vrqA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vz8 ORNITHINE
ACETYL-TRANSFERASE

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		4 ILE A 146
ARG A  26
PRO A 177
MET A 174
 None
None
None
SO4  A1391 ( 4.0A)
 1.32A 4f4dB-1vz8A:
undetectable		 4f4dB-1vz8A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vz8 ORNITHINE
ACETYL-TRANSFERASE

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		4 ILE A 146
ARG A  26
VAL A 172
MET A 174
 None
None
None
SO4  A1391 ( 4.0A)
 1.28A 4f4dB-1vz8A:
undetectable		 4f4dB-1vz8A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb8 SUPEROXIDE DISMUTASE
[FE]

(Sulfolobus
solfataricus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 ILE A 165
PRO A 101
VAL A 195
TRP A 197
 None
 1.30A 4f4dB-1wb8A:
undetectable		 4f4dB-1wb8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x55 ASPARAGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ILE A 142
PRO A 319
VAL A 413
TRP A 412
 None
 1.07A 4f4dB-1x55A:
undetectable		 4f4dB-1x55A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrv UBIQUITIN-CONJUGATIN
G LIGASE MGC351130

(Homo sapiens) 		PF00179
(UQ_con) 		4 ARG A  11
PRO A  28
MET A  34
TRP A  36
 None
 1.19A 4f4dB-1yrvA:
undetectable		 4f4dB-1yrvA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Pyrococcus
abyssi;
Pyrococcus
abyssi) 		PF00710
(Asparaginase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		4 ILE A 220
ARG C  51
PRO A  92
VAL A 136
 None
 1.30A 4f4dB-1zq1A:
4.5		 4f4dB-1zq1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0d THIOREDOXIN
PEROXIDASE 2

(Plasmodium
falciparum) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 ILE A 146
ARG A 154
PRO A 188
VAL A 180
 None
 1.21A 4f4dB-2c0dA:
undetectable		 4f4dB-2c0dA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7z ACETYLENE HYDRATASE
AHY

(Pelobacter
acetylenicus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 ILE A 340
ARG A 523
PRO A 466
VAL A 468
 None
 1.24A 4f4dB-2e7zA:
undetectable		 4f4dB-2e7zA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B

(Escherichia
coli) 		PF03372
(Exo_endo_phos) 		4 ILE A 125
PRO A  49
VAL A  82
TRP A  71
 None
 1.24A 4f4dB-2f1nA:
undetectable		 4f4dB-2f1nA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT B

(Archaeoglobus
fulgidus) 		PF12139
(APS-reductase_C)
PF13187
(Fer4_9) 		4 MET B 756
PRO B 779
MET B 787
TRP B 788
 None
 1.08A 4f4dB-2fjaB:
undetectable		 4f4dB-2fjaB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 MET A 134
ILE A 237
VAL A 151
MET A 319
 None
 1.21A 4f4dB-2gz3A:
2.5		 4f4dB-2gz3A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF12176
(MtaB) 		4 MET A 440
ILE A 389
ARG A   5
PRO A 456
 None
 1.30A 4f4dB-2i2xA:
undetectable		 4f4dB-2i2xA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1

(Anopheles
gambiae) 		PF00481
(PP2C) 		4 MET A 309
ILE A 294
VAL A 357
MET A 283
 None
 1.30A 4f4dB-2irmA:
undetectable		 4f4dB-2irmA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 PRO X 331
VAL X 309
MET X 297
TRP X 295
 None
None
UNX  X 804 (-3.8A)
None
 1.05A 4f4dB-2iv2X:
undetectable		 4f4dB-2iv2X:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		4 MET A 280
ILE A 255
PRO A 273
VAL A 194
 None
 1.12A 4f4dB-2j7cA:
undetectable		 4f4dB-2j7cA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mzw ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 ILE A 682
ARG A 627
VAL A 646
MET A 670
 None
 1.31A 4f4dB-2mzwA:
undetectable		 4f4dB-2mzwA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1t ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90) 		4 ILE A 373
PRO A 427
VAL A 433
MET A 425
 None
 1.27A 4f4dB-2o1tA:
undetectable		 4f4dB-2o1tA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy9 UPF0223 PROTEIN
BH2638

(Bacillus
halodurans) 		PF05256
(UPF0223) 		4 ILE A  77
ARG A  81
VAL A  52
TRP A  13
 None
 1.29A 4f4dB-2oy9A:
undetectable		 4f4dB-2oy9A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0s LR1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 ILE A  98
ARG A  91
PRO A  36
VAL A  78
 None
 1.26A 4f4dB-2v0sA:
undetectable		 4f4dB-2v0sA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4i GLUTAMATE
N-ACETYLTRANSFERASE
2 ALPHA CHAIN

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		4 ILE A 146
ARG A  26
PRO A 177
MET A 174
 None
 1.24A 4f4dB-2v4iA:
undetectable		 4f4dB-2v4iA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4i GLUTAMATE
N-ACETYLTRANSFERASE
2 ALPHA CHAIN

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		4 ILE A 146
ARG A  26
VAL A 172
MET A 174
 None
 1.18A 4f4dB-2v4iA:
undetectable		 4f4dB-2v4iA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va8 SKI2-TYPE HELICASE

(Sulfolobus
solfataricus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ILE A 164
ARG A 168
ARG A 165
PRO A 502
 None
 1.27A 4f4dB-2va8A:
4.6		 4f4dB-2va8A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc8 N-ACYLAMINO ACID
RACEMASE

(Thermus
thermophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 117
PRO A  83
MET A   1
TRP A 111
 None
 1.29A 4f4dB-2zc8A:
2.0		 4f4dB-2zc8A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		4 ILE A 146
PRO A 381
VAL A 297
TRP A 268
 None
 1.01A 4f4dB-3afgA:
3.0		 4f4dB-3afgA:
19.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		6 MET A  99
ILE A 111
PRO A 266
VAL A 305
MET A 308
TRP A 310
 CHD  A   2 (-4.0A)
CHD  A   2 ( 4.7A)
CHD  A   2 ( 4.5A)
CHD  A   1 ( 4.9A)
None
CHD  A   2 (-4.7A)
 0.21A 4f4dB-3aqiA:
60.7		 4f4dB-3aqiA:
99.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evk SUPEROXIDE DISMUTASE
[FE]

(Pyrobaculum
aerophilum) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 ILE A  92
PRO A 107
VAL A 201
TRP A 203
 None
 1.28A 4f4dB-3evkA:
undetectable		 4f4dB-3evkA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3b ANTI-ERBB2 ANTIBODY
CHA21

(Mus musculus) 		PF07686
(V-set) 		4 ILE C 154
PRO C  50
VAL C 231
TRP C 244
 None
 1.27A 4f4dB-3h3bC:
undetectable		 4f4dB-3h3bC:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljc ATP-DEPENDENT
PROTEASE LA

(Escherichia
coli) 		PF02190
(LON_substr_bdg) 		4 MET A  51
ILE A 100
ARG A  99
PRO A  23
 None
 1.06A 4f4dB-3ljcA:
undetectable		 4f4dB-3ljcA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll9 ISOPENTENYL
PHOSPHATE KINASE

(Methanothermobacter
thermautotrophicus) 		PF00696
(AA_kinase) 		4 ILE A 118
ARG A 117
PRO A 136
VAL A  44
 None
 1.32A 4f4dB-3ll9A:
3.7		 4f4dB-3ll9A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln3 DIHYDRODIOL
DEHYDROGENASE

(Mus musculus) 		PF00248
(Aldo_ket_red) 		4 MET A 116
ARG A 171
VAL A 142
MET A 122
 None
SO4  A 324 (-3.9A)
None
None
 1.20A 4f4dB-3ln3A:
undetectable		 4f4dB-3ln3A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ome ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		4 ILE A  50
ARG A 192
ARG A  52
MET A   0
 None
 1.29A 4f4dB-3omeA:
undetectable		 4f4dB-3omeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		4 ILE A 264
ARG A 375
MET A 767
TRP A  14
 None
 1.28A 4f4dB-3pieA:
3.2		 4f4dB-3pieA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4h PE FAMILY PROTEIN
LOW MOLECULAR WEIGHT
PROTEIN ANTIGEN 7

(Mycolicibacterium
smegmatis;
Mycolicibacterium
smegmatis) 		no annotation
PF06013
(WXG100) 		4 MET B  62
ILE A  29
ARG A  26
TRP B  54
 None
 1.09A 4f4dB-3q4hB:
undetectable		 4f4dB-3q4hB:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8d COENZYME A
TRANSFERASE

(Yersinia pestis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 ILE A 392
ARG A 414
PRO A 308
VAL A 352
 None
 1.19A 4f4dB-3s8dA:
undetectable		 4f4dB-3s8dA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tht ALKYLATED DNA REPAIR
PROTEIN ALKB HOMOLOG
8

(Homo sapiens) 		PF00076
(RRM_1)
PF13532
(2OG-FeII_Oxy_2) 		4 ILE A 144
PRO A 221
VAL A 250
MET A 224
 None
 1.07A 4f4dB-3thtA:
undetectable		 4f4dB-3thtA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upy OXIDOREDUCTASE

(Brucella
abortus) 		PF03447
(NAD_binding_3) 		4 MET A 137
ILE A 146
ARG A 429
VAL A 231
 None
 1.31A 4f4dB-3upyA:
4.1		 4f4dB-3upyA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awn DEOXYRIBONUCLEASE-1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 MET A 166
ILE A   3
PRO A 113
VAL A 116
 None
 1.34A 4f4dB-4awnA:
undetectable		 4f4dB-4awnA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 ILE A 256
ARG A 488
PRO A 316
VAL A 309
 None
 1.10A 4f4dB-4b56A:
undetectable		 4f4dB-4b56A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 ILE A  98
ARG A 189
VAL A 351
MET A 355
 None
 0.99A 4f4dB-4b90A:
undetectable		 4f4dB-4b90A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 ILE A  98
ARG A 189
VAL A 351
MET A 355
 None
 1.00A 4f4dB-4b92A:
undetectable		 4f4dB-4b92A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A

(Aspergillus
nidulans) 		PF07745
(Glyco_hydro_53) 		4 ILE A 154
PRO A  95
VAL A 110
TRP A  98
 None
 1.31A 4f4dB-4bf7A:
undetectable		 4f4dB-4bf7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bz7 HISTONE DEACETYLASE
8

(Schistosoma
mansoni) 		PF00850
(Hist_deacetyl) 		4 ILE A 411
ARG A 410
PRO A 275
VAL A 204
 None
 1.30A 4f4dB-4bz7A:
2.2		 4f4dB-4bz7A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN

(Plasmodium
berghei;
synthetic
construct) 		PF00022
(Actin) 		4 MET A 124
ILE A  11
VAL A  77
TRP A  80
 None
 1.26A 4f4dB-4cbwA:
undetectable		 4f4dB-4cbwA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chc POLYMERASE ACIDIC
PROTEIN

(Thogoto
thogotovirus) 		no annotation 4 ILE A 165
PRO A   5
VAL A 152
TRP A 151
 None
 1.18A 4f4dB-4chcA:
undetectable		 4f4dB-4chcA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1
RNA-BINDING PROTEIN
FUS

(Homo sapiens;
Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ)
no annotation 		4 MET A 308
ILE A 398
PRO B 525
TRP A 460
 None
 1.21A 4f4dB-4fddA:
undetectable		 4f4dB-4fddA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igb LPXTG CELL WALL
SURFACE PROTEIN

(Streptococcus
gordonii) 		no annotation 4 MET D 399
ILE D 414
PRO D 353
VAL D 342
 None
 1.29A 4f4dB-4igbD:
undetectable		 4f4dB-4igbD:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ob1 COBALT-CONTAINING
NITRILE HYDRATASE
SUBUNIT ALPHA

(Pseudonocardia
thermophila) 		PF02979
(NHase_alpha) 		4 ILE A  85
PRO A 172
VAL A  60
TRP A  63
 None
 1.29A 4f4dB-4ob1A:
undetectable		 4f4dB-4ob1A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p05 ARYLSULFATE
SULFOTRANSFERASE
ASST

(Escherichia
coli) 		PF05935
(Arylsulfotrans)
PF17425
(Arylsulfotran_N) 		4 MET A 569
ILE A 179
ARG A 187
VAL A  43
 None
 1.29A 4f4dB-4p05A:
undetectable		 4f4dB-4p05A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00118
(Cpn60_TCP1) 		4 MET A 193
ILE A 343
ARG A 346
PRO A 279
 None
 1.04A 4f4dB-4pj1A:
undetectable		 4f4dB-4pj1A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl7 ACTIN,THYMOSIN
BETA-4

(Homo sapiens;
Komagataella
phaffii) 		PF00022
(Actin)
PF01290
(Thymosin) 		4 MET A 123
ILE A  10
VAL A  76
TRP A  79
 None
 1.23A 4f4dB-4pl7A:
2.1		 4f4dB-4pl7A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 ILE A 889
ARG A 796
PRO A 863
VAL A 831
 None
 1.33A 4f4dB-4q73A:
2.7		 4f4dB-4q73A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13581
(HATPase_c_2) 		4 ILE A 151
ARG A 175
PRO A 294
TRP A 293
 None
ANP  A 402 (-3.8A)
None
ANP  A 402 (-4.4A)
 1.26A 4f4dB-4r39A:
undetectable		 4f4dB-4r39A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkm MCCA

(Wolinella
succinogenes) 		no annotation 4 MET A 492
ILE A 517
VAL A 530
TRP A 544
 None
 1.21A 4f4dB-4rkmA:
undetectable		 4f4dB-4rkmA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 352
PRO A 318
MET A 316
TRP A 333
 None
 1.26A 4f4dB-4uy9A:
undetectable		 4f4dB-4uy9A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmp HEAVY CHAIN OF
ANTIBODY VRC08
LIGHT CHAIN OF
ANTIBODY VRC08

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 ILE H  20
PRO L  44
VAL H  93
TRP H 103
 None
 1.12A 4f4dB-4xmpH:
undetectable		 4f4dB-4xmpH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 892
PRO A 857
MET A 855
TRP A 872
 None
 1.20A 4f4dB-4xufA:
undetectable		 4f4dB-4xufA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 MET A 403
ARG A 263
ARG A 417
VAL A 281
 None
 1.07A 4f4dB-4yzwA:
undetectable		 4f4dB-4yzwA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8z NEUTROPHIL ELASTASE

(Homo sapiens) 		PF00089
(Trypsin) 		4 ILE A 114
PRO A 198
VAL A  31
MET A  53
 None
 1.33A 4f4dB-5a8zA:
undetectable		 4f4dB-5a8zA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdo DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B

(Staphylococcus
aureus) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 MET B 528
ILE B 482
ARG B 479
VAL B 464
 None
 1.31A 4f4dB-5cdoB:
5.9		 4f4dB-5cdoB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e24 SUPPRESSOR OF
HAIRLESS PROTEIN

(Drosophila
melanogaster) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		4 MET E 219
ILE E 124
PRO E 424
VAL E 428
 None
None
EDO  E 616 (-4.5A)
None
 1.29A 4f4dB-5e24E:
undetectable		 4f4dB-5e24E:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e44 FNR REGULATOR

(Aliivibrio
fischeri) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 ILE A 200
ARG A 197
VAL A 226
MET A 223
 None
 1.07A 4f4dB-5e44A:
undetectable		 4f4dB-5e44A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS

(Mus musculus) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		4 MET C 171
ILE C  76
PRO C 376
VAL C 380
 None
None
None
EDO  C 510 (-3.9A)
 1.21A 4f4dB-5eg6C:
undetectable		 4f4dB-5eg6C:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32

(Mycobacterium
marinum) 		PF00501
(AMP-binding) 		4 ILE A 601
ARG A 603
PRO A 227
MET A 232
 None
None
None
5SV  A 701 (-3.6A)
 1.13A 4f4dB-5ey9A:
4.0		 4f4dB-5ey9A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C

(Homo sapiens) 		PF02373
(JmjC) 		4 ILE A2375
ARG A2379
PRO A2191
VAL A2193
 None
 1.19A 4f4dB-5fzoA:
undetectable		 4f4dB-5fzoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkk PUTATIVE HOMING
ENDONUCLEASE

(Thermotoga
neapolitana) 		PF00961
(LAGLIDADG_1) 		4 ILE A 122
ARG A 147
PRO A  36
VAL A  22
 None
 1.33A 4f4dB-5gkkA:
undetectable		 4f4dB-5gkkA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqw PUTATIVE POLYKETIDE
SYNTHASE

(Brevibacillus
brevis) 		PF14765
(PS-DH) 		4 MET A2419
ILE A2449
PRO A2441
TRP A2289
 None
 1.15A 4f4dB-5hqwA:
undetectable		 4f4dB-5hqwA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Saccharomyces
cerevisiae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 ILE C  63
ARG C  66
PRO C 132
VAL C 142
 None
 0.92A 4f4dB-5ip7C:
undetectable		 4f4dB-5ip7C:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6o PUTATIVE POLYKETIDE
SYNTHASE

(Brevibacillus
brevis) 		PF14765
(PS-DH) 		5 MET A2132
ILE A2171
PRO A2163
VAL A2000
TRP A2002
 None
 1.33A 4f4dB-5j6oA:
undetectable		 4f4dB-5j6oA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA

(Salmonella
enterica) 		PF13599
(Pentapeptide_4)
PF13981
(SopA) 		4 MET A 333
ILE A 360
PRO A 314
TRP A 330
 None
 1.30A 4f4dB-5jw7A:
undetectable		 4f4dB-5jw7A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5med ARACHIDONATE
15-LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		4 ILE A 121
ARG A 112
PRO A 231
TRP A 237
 None
 1.31A 4f4dB-5medA:
undetectable		 4f4dB-5medA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ILE A4164
PRO A4297
VAL A4309
TRP A4308
 None
 1.19A 4f4dB-5nugA:
undetectable		 4f4dB-5nugA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocp -

(-) 		no annotation 4 ILE A  53
ARG A  50
PRO A  64
TRP A  70
 None
 1.28A 4f4dB-5ocpA:
4.5		 4f4dB-5ocpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4u DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Saccharomyces
cerevisiae) 		no annotation 4 ILE C  63
ARG C  66
PRO C 132
VAL C 142
 None
 0.99A 4f4dB-5w4uC:
undetectable		 4f4dB-5w4uC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		4 ILE A 459
ARG A 453
PRO A 737
VAL A 488
 None
 1.23A 4f4dB-5welA:
4.5		 4f4dB-5welA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1a -

(-) 		no annotation 4 MET A 168
ILE A 171
VAL A  70
MET A 189
 None
 1.35A 4f4dB-5y1aA:
undetectable		 4f4dB-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris) 		no annotation 4 ILE A 473
ARG A 479
ARG A 475
MET A 135
 None
 1.34A 4f4dB-5z0uA:
undetectable		 4f4dB-5z0uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bck N49P7 FAB HEAVY
CHAIN OF N29P7 IGG
N49P7 FAB LIGHT
CHAIN FROM N49P7 IGG

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 ILE H  20
PRO L  44
VAL H  93
TRP H 103
 None
 1.15A 4f4dB-6bckH:
undetectable		 4f4dB-6bckH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM
V-TYPE PROTON ATPASE
SUBUNIT D
V0 ASSEMBLY PROTEIN
1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation
no annotation 		4 ILE A 202
ARG A 205
PRO N 260
TRP B 132
 None
 0.99A 4f4dB-6c6lA:
undetectable		 4f4dB-6c6lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8a INOSITOL
POLYPHOSPHATE
MULTIKINASE

(Homo sapiens) 		no annotation 4 ILE A 233
ARG A 382
PRO A 140
VAL A 133
 None
 1.30A 4f4dB-6c8aA:
undetectable		 4f4dB-6c8aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT

(Pyrococcus
furiosus) 		no annotation 4 ILE M 134
PRO M  72
VAL M 118
MET M  67
 None
 1.31A 4f4dB-6cfwM:
undetectable		 4f4dB-6cfwM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cuf


(;
) 		no annotation
no annotation 		4 ILE 8  20
PRO 7  44
VAL 8  93
TRP 8 103
 None
 1.11A 4f4dB-6cuf8:
undetectable		 4f4dB-6cuf8:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d3i -

(-) 		no annotation 4 ILE A  95
ARG A 281
PRO A 121
VAL A 124
 AKG  A 302 (-4.2A)
AKG  A 302 (-3.1A)
None
None
 1.33A 4f4dB-6d3iA:
undetectable		 4f4dB-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d3i -

(-) 		no annotation 4 ILE A 106
ARG A 281
PRO A 121
VAL A 124
 AKG  A 302 (-4.6A)
AKG  A 302 (-3.1A)
None
None
 1.34A 4f4dB-6d3iA:
undetectable		 4f4dB-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eq8 PERIPLASMIC
ALPHA-GALACTOSIDE-BI
NDING PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 4 ILE D  34
ARG D 648
ARG D 123
MET D 636
 None
 1.26A 4f4dB-6eq8D:
undetectable		 4f4dB-6eq8D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 4 ILE A1751
ARG A 780
VAL A1662
MET A1659
 None
 1.32A 4f4dB-6ez8A:
undetectable		 4f4dB-6ez8A:
undetectable