SIMILAR PATTERNS OF AMINO ACIDS FOR 4F4D_A_CHDA506

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dot DUCK OVOTRANSFERRIN

(Anas
platyrhynchos) 		PF00405
(Transferrin) 		4 PRO A 128
LEU A 132
ILE A 138
ARG A 110
 None
 1.30A 4f4dA-1dotA:
0.7		 4f4dA-1dotA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvc OVOTRANSFERRIN

(Anas
platyrhynchos) 		PF00405
(Transferrin) 		4 PRO A 131
LEU A 135
ILE A 141
ARG A 113
 None
 1.25A 4f4dA-1gvcA:
undetectable		 4f4dA-1gvcA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT

(Klebsiella
pneumoniae) 		PF02286
(Dehydratase_LU) 		4 PRO A 111
LEU A  52
ILE A  49
ARG A  57
 None
 0.89A 4f4dA-1iwpA:
undetectable		 4f4dA-1iwpA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krm ADENOSINE DEAMINASE

(Bos taurus) 		PF00962
(A_deaminase) 		4 PRO A  36
LEU A  35
ILE A  33
ARG A  31
 None
 1.19A 4f4dA-1krmA:
0.0		 4f4dA-1krmA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		4 PRO A 146
LEU A 147
ILE A  95
ARG A  96
 None
 1.45A 4f4dA-1rf5A:
0.0		 4f4dA-1rf5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uus STAT PROTEIN

(Dictyostelium
discoideum) 		PF00017
(SH2)
PF09267
(Dict-STAT-coil) 		4 PRO A 287
LEU A 288
ILE A 350
ARG A 395
 None
 1.19A 4f4dA-1uusA:
undetectable		 4f4dA-1uusA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcw PROTEASE DEGS

(Escherichia
coli) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 PRO A 237
LEU A 240
ILE A 244
ARG A 256
 None
 1.07A 4f4dA-1vcwA:
undetectable		 4f4dA-1vcwA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9y CYSTEINE PROTEINASE

(Staphylococcus
aureus) 		PF05543
(Peptidase_C47)
PF14731
(Staphopain_pro) 		4 PRO A 208
LEU A 146
ILE A 149
ARG A 174
 None
 1.21A 4f4dA-1x9yA:
undetectable		 4f4dA-1x9yA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		4 PRO A 177
LEU A 125
ILE A 128
ARG A 127
 None
 1.47A 4f4dA-1z6rA:
undetectable		 4f4dA-1z6rA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kum C-C MOTIF CHEMOKINE
27

(Homo sapiens) 		PF00048
(IL8) 		4 PRO A  17
LEU A  18
ILE A  52
ARG A  50
 None
 1.42A 4f4dA-2kumA:
undetectable		 4f4dA-2kumA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p19 TRANSCRIPTIONAL
REGULATOR

(Corynebacterium
glutamicum) 		PF07702
(UTRA) 		4 PRO A  49
LEU A  42
ILE A  52
ARG A  40
 None
 1.35A 4f4dA-2p19A:
undetectable		 4f4dA-2p19A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4h VESTITONE REDUCTASE

(Medicago sativa) 		PF01370
(Epimerase) 		4 PRO X 291
LEU X 293
ILE X 190
ARG X 250
 None
 1.50A 4f4dA-2p4hX:
2.7		 4f4dA-2p4hX:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1

(Pyrococcus
abyssi) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 PRO A  64
LEU A  62
ILE A  74
ARG A  72
 None
 1.39A 4f4dA-2pnzA:
undetectable		 4f4dA-2pnzA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Aspergillus
oryzae) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PRO A 137
LEU A 138
ILE A 341
ARG A 327
 None
 1.37A 4f4dA-2ps2A:
undetectable		 4f4dA-2ps2A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE

(Homo sapiens) 		PF00368
(HMG-CoA_red) 		4 PRO A 477
LEU A 481
ILE A 494
ARG A 490
 None
 1.44A 4f4dA-2r4fA:
undetectable		 4f4dA-2r4fA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r87 PURP PROTEIN PF1517

(Pyrococcus
furiosus) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		4 PRO A 183
LEU A 269
ILE A 113
ARG A 251
 None
 1.40A 4f4dA-2r87A:
2.7		 4f4dA-2r87A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE

(Pseudomonas
fluorescens) 		PF00378
(ECH_1) 		4 PRO C  83
LEU C  86
ILE C  90
ARG C  39
 None
 1.45A 4f4dA-2vsuC:
undetectable		 4f4dA-2vsuC:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xp1 SPT6

(Antonospora
locustae) 		PF14633
(SH2_2) 		4 PRO A 793
LEU A 794
ILE A 862
ARG A 867
 None
 1.08A 4f4dA-2xp1A:
undetectable		 4f4dA-2xp1A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 PRO A 173
LEU A 174
ILE A 121
ARG A 120
 None
 1.02A 4f4dA-2xydA:
undetectable		 4f4dA-2xydA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zy2 L-ASPARTATE
4-CARBOXYLYASE

(Pseudomonas sp.
ATCC 19121) 		PF00155
(Aminotran_1_2) 		4 PRO A 118
LEU A 122
ILE A  83
ARG A  86
 None
 1.42A 4f4dA-2zy2A:
undetectable		 4f4dA-2zy2A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5m UNCHARACTERIZED
PROTEIN

(Rhodopirellula
baltica) 		PF04289
(DUF447) 		4 PRO A  27
LEU A  26
ILE A  24
ARG A  40
 None
 1.22A 4f4dA-3b5mA:
undetectable		 4f4dA-3b5mA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db1 STS-2 PROTEIN

(Mus musculus) 		PF00300
(His_Phos_1) 		4 PRO A 561
LEU A 562
ILE A 361
ARG A 359
 None
 1.33A 4f4dA-3db1A:
undetectable		 4f4dA-3db1A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB

(Sinorhizobium
meliloti) 		no annotation 4 PRO A 257
LEU A 258
ILE A 247
ARG A 220
 None
 1.41A 4f4dA-3e4pA:
undetectable		 4f4dA-3e4pA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejk DTDP SUGAR ISOMERASE

(Desulfovibrio
alaskensis) 		PF00908
(dTDP_sugar_isom) 		4 PRO A  18
LEU A  17
ILE A  15
ARG A 113
 None
None
PG4  A 177 (-4.3A)
None
 1.08A 4f4dA-3ejkA:
undetectable		 4f4dA-3ejkA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2k HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF01359
(Transposase_1) 		4 PRO A 153
LEU A 152
ILE A 126
ARG A  33
 None
 1.32A 4f4dA-3f2kA:
undetectable		 4f4dA-3f2kA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4s PUTATIVE
UNCHARACTERIZED
PROTEIN

(Wolbachia
endosymbiont of
Drosophila
melanogaster) 		PF13462
(Thioredoxin_4) 		4 PRO A  37
LEU A  33
ILE A  78
ARG A  80
 None
 1.47A 4f4dA-3f4sA:
undetectable		 4f4dA-3f4sA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE

(Comamonas
testosteroni) 		PF00155
(Aminotran_1_2) 		4 PRO A 118
LEU A 122
ILE A  83
ARG A  86
 None
 1.42A 4f4dA-3fddA:
undetectable		 4f4dA-3fddA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htk E3 SUMO-PROTEIN
LIGASE MMS21

(Saccharomyces
cerevisiae) 		PF11789
(zf-Nse) 		4 PRO C 167
LEU C 164
ILE C 161
ARG C 244
 None
 1.28A 4f4dA-3htkC:
undetectable		 4f4dA-3htkC:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN CATALYTIC
LIGHT CHAIN LC-1,
MANTLE MUSCLE

(Todarodes
pacificus) 		PF13405
(EF-hand_6) 		4 PRO C  70
LEU C  69
ILE C   8
ARG C  12
 None
 1.36A 4f4dA-3i5gC:
undetectable		 4f4dA-3i5gC:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jap EIF3C

(Saccharomyces
cerevisiae) 		PF00203
(Ribosomal_S19) 		4 PRO p 355
LEU p 258
ILE p 262
ARG p 265
 None
 1.41A 4f4dA-3japp:
undetectable		 4f4dA-3japp:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PRO A 150
LEU A 151
ILE A 140
ARG A 309
 None
 1.09A 4f4dA-3jv7A:
undetectable		 4f4dA-3jv7A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF00067
(p450) 		4 PRO A 112
LEU A 115
ILE A 457
ARG A 396
 None
None
None
HEM  A 520 ( 2.8A)
 1.44A 4f4dA-3k9yA:
undetectable		 4f4dA-3k9yA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mh9 LIPOPROTEIN LPRG

(Mycobacterium
tuberculosis) 		no annotation 4 PRO C  43
LEU C  44
ILE C 166
ARG C 157
 None
 1.20A 4f4dA-3mh9C:
undetectable		 4f4dA-3mh9C:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mha LIPOPROTEIN LPRG

(Mycobacterium
tuberculosis) 		PF07161
(LppX_LprAFG) 		4 PRO A  43
LEU A  44
ILE A 166
ARG A 157
 None
 1.32A 4f4dA-3mhaA:
undetectable		 4f4dA-3mhaA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2o BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF02784
(Orn_Arg_deC_N) 		4 PRO A 489
LEU A 547
ILE A 298
ARG A  77
 None
 1.05A 4f4dA-3n2oA:
undetectable		 4f4dA-3n2oA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH

(Actinoplanes
sp. SE50/110) 		PF01547
(SBP_bac_1) 		4 PRO A 295
LEU A  67
ILE A  63
ARG A  82
 None
 1.45A 4f4dA-3oo9A:
undetectable		 4f4dA-3oo9A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe7 URACIL PERMEASE

(Escherichia
coli) 		PF00860
(Xan_ur_permease) 		4 PRO A 184
LEU A 180
ILE A 297
ARG A 299
 None
 1.18A 4f4dA-3qe7A:
undetectable		 4f4dA-3qe7A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2c 30S RIBOSOMAL
PROTEIN S10

(Aquifex
aeolicus) 		PF00338
(Ribosomal_S10) 		4 PRO J  43
LEU J  42
ILE J  40
ARG J   7
 None
 1.07A 4f4dA-3r2cJ:
undetectable		 4f4dA-3r2cJ:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqq L2 PROTEIN III
(PENTON BASE)

(Human
mastadenovirus
B) 		PF01686
(Adeno_Penton_B) 		4 PRO A 355
LEU A 234
ILE A 235
ARG A 225
 None
 1.37A 4f4dA-4aqqA:
undetectable		 4f4dA-4aqqA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 PRO A  44
LEU A  43
ILE A  74
ARG A 120
 None
 1.30A 4f4dA-4bc5A:
undetectable		 4f4dA-4bc5A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9

(Homo sapiens) 		PF11979
(DUF3480) 		4 PRO A1071
LEU A1034
ILE A1059
ARG A1095
 None
 1.44A 4f4dA-4bkwA:
undetectable		 4f4dA-4bkwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp8 ALLOPHANATE
HYDROLASE

(Pseudomonas sp.
ADP) 		PF01425
(Amidase) 		4 PRO A 273
LEU A 388
ILE A 444
ARG A 191
 None
 1.36A 4f4dA-4cp8A:
undetectable		 4f4dA-4cp8A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA

(Brucella
abortus) 		PF00677
(Lum_binding) 		4 PRO A 130
LEU A 133
ILE A 187
ARG A 192
 None
 1.06A 4f4dA-4e0fA:
undetectable		 4f4dA-4e0fA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e37 CATALASE

(Pseudomonas
aeruginosa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 PRO A 467
LEU A 463
ILE A 459
ARG A 456
 None
 1.21A 4f4dA-4e37A:
undetectable		 4f4dA-4e37A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Burkholderia
pseudomallei) 		PF00753
(Lactamase_B) 		4 PRO A 175
LEU A 172
ILE A 237
ARG A 197
 None
 1.44A 4f4dA-4efzA:
undetectable		 4f4dA-4efzA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i16 CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 11

(Mus musculus) 		PF00619
(CARD) 		4 PRO A 100
LEU A 102
ILE A  37
ARG A  72
 None
None
None
SO4  A 202 ( 3.0A)
 1.46A 4f4dA-4i16A:
undetectable		 4f4dA-4i16A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F

(Bacillus
subtilis) 		PF12895
(ANAPC3)
PF13424
(TPR_12) 		4 PRO A 218
LEU A 220
ILE A 179
ARG A 180
 None
 1.39A 4f4dA-4i9cA:
undetectable		 4f4dA-4i9cA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1p NHEA

(Bacillus cereus) 		PF05791
(Bacillus_HBL) 		4 PRO A 261
LEU A 262
ILE A 183
ARG A 182
 None
 1.00A 4f4dA-4k1pA:
undetectable		 4f4dA-4k1pA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbx UNCHARACTERIZED
PROTEIN YHFX

(Escherichia
coli) 		PF01168
(Ala_racemase_N) 		4 PRO A 207
LEU A 211
ILE A 215
ARG A 218
 None
 1.29A 4f4dA-4kbxA:
undetectable		 4f4dA-4kbxA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A

(Burkholderia
glumae) 		PF05853
(BKACE) 		4 PRO A  27
LEU A  31
ILE A  43
ARG A  39
 None
 1.42A 4f4dA-4nnbA:
undetectable		 4f4dA-4nnbA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 PRO A 180
LEU A 179
ILE A 177
ARG A 208
 None
 1.04A 4f4dA-4p4sA:
undetectable		 4f4dA-4p4sA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 PRO B 180
LEU B 179
ILE B 177
ARG B 208
 None
 1.03A 4f4dA-4p4sB:
undetectable		 4f4dA-4p4sB:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht GENERAL SECRETORY
PATHWAY PROTEIN E
TYPE II SECRETION
SYSTEM PROTEIN L

(Vibrio
vulnificus;
Vibrio
vulnificus) 		PF00437
(T2SSE)
PF05134
(T2SSL) 		4 PRO X  82
LEU X  85
ILE X  89
ARG A  53
 None
 1.33A 4f4dA-4phtX:
undetectable		 4f4dA-4phtX:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 PRO B 456
LEU B 455
ILE B 431
ARG B 499
 None
 1.12A 4f4dA-4plbB:
2.2		 4f4dA-4plbB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyh PHOSPHOGLUCAN
PHOSPHATASE DSP4,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00782
(DSPc)
PF16561
(AMPK1_CBM) 		4 PRO A 206
LEU A 210
ILE A 241
ARG A 242
 None
 1.39A 4f4dA-4pyhA:
undetectable		 4f4dA-4pyhA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO

(Escherichia
coli) 		PF02624
(YcaO) 		4 PRO A 217
LEU A 216
ILE A 214
ARG A 208
 None
 1.10A 4f4dA-4q85A:
undetectable		 4f4dA-4q85A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7u UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		4 PRO A  28
LEU A  30
ILE A  51
ARG A  67
 None
 1.37A 4f4dA-4r7uA:
undetectable		 4f4dA-4r7uA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		4 PRO A 177
LEU A 315
ILE A 307
ARG A 305
 None
 1.10A 4f4dA-4raeA:
1.3		 4f4dA-4raeA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Neisseria
meningitidis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 PRO A 284
LEU A 287
ILE A 291
ARG A 298
 None
 1.05A 4f4dA-4rybA:
undetectable		 4f4dA-4rybA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7b MARINER MOS1
TRANSPOSASE

(Drosophila
mauritiana) 		PF01359
(Transposase_1) 		4 PRO A 272
LEU A 271
ILE A 245
ARG A 151
 None
 1.45A 4f4dA-4u7bA:
undetectable		 4f4dA-4u7bA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ww7 EKC/KEOPS COMPLEX
SUBUNIT BUD32

(Saccharomyces
cerevisiae) 		PF06293
(Kdo) 		4 PRO A  92
LEU A 106
ILE A 104
ARG A  54
 AMP  A 301 ( 4.7A)
AMP  A 301 ( 4.4A)
None
None
 1.36A 4f4dA-4ww7A:
undetectable		 4f4dA-4ww7A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2

(Caenorhabditis
elegans) 		PF00004
(AAA) 		4 PRO A 391
LEU A 338
ILE A 341
ARG A 340
 None
 1.18A 4f4dA-4xguA:
undetectable		 4f4dA-4xguA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		4 PRO A1566
LEU A1570
ILE A1543
ARG A 340
 None
 1.39A 4f4dA-4yknA:
undetectable		 4f4dA-4yknA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq1 GLUCOSE-6-PHOSPHATE
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 PRO A 346
LEU A 509
ILE A 302
ARG A 303
 None
 1.39A 4f4dA-5aq1A:
3.4		 4f4dA-5aq1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyw TRIOSEPHOSPHATE
ISOMERASE

(Litopenaeus
vannamei) 		PF00121
(TIM) 		4 PRO A 126
LEU A 163
ILE A 207
ARG A 190
 None
 1.50A 4f4dA-5eywA:
undetectable		 4f4dA-5eywA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		4 PRO A 856
LEU A 857
ILE A 877
ARG A 873
 None
 1.18A 4f4dA-5h42A:
undetectable		 4f4dA-5h42A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 PRO A1124
LEU A1031
ILE A1034
ARG A1033
 None
 1.23A 4f4dA-5m5pA:
undetectable		 4f4dA-5m5pA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8o MITOCHONDRIAL IMPORT
RECEPTOR SUBUNIT
TOM40

(Neurospora
crassa) 		PF01459
(Porin_3) 		4 PRO A  41
LEU A 151
ILE A 130
ARG A 128
 None
 1.23A 4f4dA-5o8oA:
undetectable		 4f4dA-5o8oA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A

(Methanothermococcus
thermolithotrophicus;
Methanothermococcus
thermolithotrophicus) 		PF01058
(Oxidored_q6)
PF00374
(NiFeSe_Hases) 		4 PRO E 295
LEU E 289
ILE E 281
ARG F  48
 None
 1.16A 4f4dA-5odrE:
undetectable		 4f4dA-5odrE:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 4 PRO A 469
LEU A 448
ILE A 423
ARG A 421
 None
 1.42A 4f4dA-5oynA:
2.7		 4f4dA-5oynA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ty0 ELONGATION FACTOR G

(Legionella
pneumophila) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		4 PRO A 261
LEU A 167
ILE A 184
ARG A 217
 None
 1.30A 4f4dA-5ty0A:
undetectable		 4f4dA-5ty0A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5va8 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Paraburkholderia
phymatum) 		PF13561
(adh_short_C2) 		4 PRO A 225
LEU A  19
ILE A 138
ARG A 157
 None
NAP  A 301 (-3.8A)
NAP  A 301 ( 4.9A)
NAP  A 301 ( 3.0A)
 1.50A 4f4dA-5va8A:
2.4		 4f4dA-5va8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9d ACYL-COENZYME A
OXIDASE 1

(Yarrowia
lipolytica) 		no annotation 4 PRO A  52
LEU A  54
ILE A  48
ARG A  93
 None
 1.21A 4f4dA-5y9dA:
undetectable		 4f4dA-5y9dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5

(Aquareovirus C) 		no annotation 4 PRO 4 686
LEU 4 685
ILE 4 679
ARG 4 655
 None
 1.42A 4f4dA-5zvs4:
undetectable		 4f4dA-5zvs4:
undetectable