SIMILAR PATTERNS OF AMINO ACIDS FOR 4F4D_A_CHDA504_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9n U2A'

(Homo sapiens) 		PF14580
(LRR_9) 		5 LEU A 109
LEU A 118
LEU A 145
ILE A  79
VAL A 125
 None
 1.21A 4f4dA-1a9nA:
undetectable		 4f4dA-1a9nA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjw ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		5 LEU A 312
LEU A 307
LEU A 303
ILE A 330
VAL A 346
 None
 1.09A 4f4dA-1bjwA:
0.9		 4f4dA-1bjwA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbz CATALASE

(Micrococcus
luteus) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 LEU A 303
LEU A 301
ARG A 305
LYS A 308
GLN A 313
 None
 1.27A 4f4dA-1hbzA:
undetectable		 4f4dA-1hbzA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2w BETA-LACTAMASE

(Bacillus
licheniformis) 		PF13354
(Beta-lactamase2) 		5 LEU A  80
LEU A  81
LEU A 199
ILE A 138
GLN A 135
 None
 1.28A 4f4dA-1i2wA:
undetectable		 4f4dA-1i2wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		5 LEU A1175
LEU A1197
LEU A1217
ILE A1158
THR A1241
 None
 1.28A 4f4dA-1jl5A:
0.0		 4f4dA-1jl5A:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		10 MET A  46
LEU A  59
LEU A  62
ARG A  87
LYS A  90
ILE A  91
GLN A  94
THR A 170
HIS A 235
VAL A 277
 None
 0.73A 4f4dA-1lbqA:
48.4		 4f4dA-1lbqA:
49.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		6 MET A  46
LEU A  68
ARG A  87
THR A 170
HIS A 235
VAL A 277
 None
 1.15A 4f4dA-1lbqA:
48.4		 4f4dA-1lbqA:
49.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica) 		PF00155
(Aminotran_1_2) 		5 MET A 102
LEU A 184
LEU A 152
LEU A 135
ILE A 208
 None
 1.10A 4f4dA-1lc7A:
2.0		 4f4dA-1lc7A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpx ALPHA-AMINO ACID
ESTER HYDROLASE

(Xanthomonas
citri) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		5 LEU A 634
LEU A 419
LEU A 421
ILE A 496
THR A 484
 None
 1.29A 4f4dA-1mpxA:
0.9		 4f4dA-1mpxA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		5 LEU A  83
LEU A 107
LEU A 129
ILE A  62
VAL A  72
 None
 1.03A 4f4dA-1oznA:
undetectable		 4f4dA-1oznA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9c APC35852

(Geobacillus
stearothermophilus) 		PF01965
(DJ-1_PfpI) 		5 LEU A 112
LEU A 132
LEU A 174
ILE A  90
THR A 148
 None
 1.19A 4f4dA-1u9cA:
undetectable		 4f4dA-1u9cA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wws HYPOTHETICAL PROTEIN
TTHA1479

(Thermus
thermophilus) 		PF09123
(DUF1931) 		5 LEU A  39
LEU A  36
LEU A   2
ILE A  62
GLN A  67
 None
 1.12A 4f4dA-1wwsA:
undetectable		 4f4dA-1wwsA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl6 BOTULINUM NEUROTOXIN
TYPE E

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 LEU A 103
LEU A 106
LEU A 220
ILE A  93
VAL A 183
 None
 1.19A 4f4dA-1zl6A:
undetectable		 4f4dA-1zl6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Aquifex
aeolicus) 		PF03331
(LpxC) 		5 LEU A 250
LEU A 247
LEU A 243
THR A 156
VAL A 138
 None
 0.89A 4f4dA-2go4A:
undetectable		 4f4dA-2go4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 LEU A 112
LEU A 109
ILE A  84
VAL A  98
ARG A  71
 None
 1.24A 4f4dA-2h2qA:
undetectable		 4f4dA-2h2qA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0n INVASIN IPAD

(Shigella
flexneri) 		PF06511
(IpaD) 		5 LEU A 257
LEU A 260
LEU A 190
ILE A 253
VAL A 170
 None
 1.25A 4f4dA-2j0nA:
undetectable		 4f4dA-2j0nA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ory LIPASE

(Photobacterium
sp. M37) 		PF01764
(Lipase_3) 		5 LEU A 195
LEU A 187
LEU A 183
ILE A 160
THR A 171
 None
 1.18A 4f4dA-2oryA:
undetectable		 4f4dA-2oryA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN

(Staphylococcus
epidermidis) 		PF01933
(UPF0052) 		5 LEU A 307
LEU A  18
LEU A  15
ILE A 249
THR A  30
 None
 1.23A 4f4dA-2ppvA:
undetectable		 4f4dA-2ppvA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vii PSP OPERON
TRANSCRIPTIONAL
ACTIVATOR

(Escherichia
coli) 		PF00158
(Sigma54_activat) 		5 LEU A  77
LEU A  73
ARG A  98
ILE A  61
THR A 111
 None
 1.30A 4f4dA-2viiA:
undetectable		 4f4dA-2viiA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		5 LEU A 784
LEU A 809
LEU A 832
ILE A 859
ARG A 626
 None
None
None
None
BR  A1894 (-4.2A)
 1.29A 4f4dA-2vmfA:
undetectable		 4f4dA-2vmfA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 LEU A 508
LEU A 451
LEU A 466
ILE A 617
GLN A 706
 None
 1.20A 4f4dA-2wghA:
undetectable		 4f4dA-2wghA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yeq ALKALINE PHOSPHATASE
D

(Bacillus
subtilis) 		PF09423
(PhoD)
PF16655
(PhoD_N) 		5 LEU A 305
LEU A 306
LEU A 314
ILE A 332
VAL A 376
 None
 1.29A 4f4dA-2yeqA:
undetectable		 4f4dA-2yeqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yeq ALKALINE PHOSPHATASE
D

(Bacillus
subtilis) 		PF09423
(PhoD)
PF16655
(PhoD_N) 		5 LEU A 306
LEU A 314
LEU A 318
GLN A 331
VAL A 376
 None
 1.30A 4f4dA-2yeqA:
undetectable		 4f4dA-2yeqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z69 DNR PROTEIN

(Pseudomonas
aeruginosa) 		PF00027
(cNMP_binding) 		5 LEU A  10
LEU A  11
LEU A  25
ILE A  57
GLN A 107
 None
 1.28A 4f4dA-2z69A:
undetectable		 4f4dA-2z69A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoa PHOSPHOHYDROLASE

(Klebsiella
aerogenes) 		PF00149
(Metallophos) 		5 LEU A  76
LEU A  94
ILE A  51
VAL A  32
ARG A  14
 None
 1.22A 4f4dA-2zoaA:
undetectable		 4f4dA-2zoaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvw PROLIFERATING CELL
NUCLEAR ANTIGEN 2

(Arabidopsis
thaliana) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 LEU A  79
LEU A  16
LEU A  72
ILE A  88
VAL A  99
 None
 1.19A 4f4dA-2zvwA:
undetectable		 4f4dA-2zvwA:
19.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		8 LEU A  89
LEU A  92
LEU A  98
ILE A 119
GLN A 122
THR A 198
HIS A 263
VAL A 305
 None
CHD  A   1 (-4.8A)
CHD  A   1 (-4.3A)
None
CHD  A   1 ( 4.1A)
None
CHD  A   1 (-4.3A)
CHD  A   1 ( 4.9A)
 0.60A 4f4dA-3aqiA:
60.3		 4f4dA-3aqiA:
99.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayd GALECTIN-3

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 LEU A 147
LEU A 234
ILE A 171
GLN A 187
THR A 133
 None
None
None
SO4  A   4 (-3.8A)
None
 1.22A 4f4dA-3aydA:
undetectable		 4f4dA-3aydA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bww PROTEIN OF UNKNOWN
FUNCTION
DUF692/COG3220

(Histophilus
somni) 		PF05114
(DUF692) 		5 LEU A 196
LEU A 261
LEU A 301
ARG A 260
ILE A 191
 None
 1.04A 4f4dA-3bwwA:
undetectable		 4f4dA-3bwwA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 153
LEU A 150
LEU A 123
ILE A 182
VAL A 240
 None
 1.26A 4f4dA-3fhtA:
undetectable		 4f4dA-3fhtA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7u ALDO-KETO REDUCTASE

(Arabidopsis
thaliana) 		PF00248
(Aldo_ket_red) 		5 LEU A  65
LEU A  62
LEU A 103
THR A  79
VAL A  31
 None
 1.18A 4f4dA-3h7uA:
undetectable		 4f4dA-3h7uA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htv D-ALLOSE KINASE

(Escherichia
coli) 		PF00480
(ROK) 		5 LEU A 106
LEU A 102
LEU A  98
ILE A  53
VAL A  40
 None
 1.14A 4f4dA-3htvA:
undetectable		 4f4dA-3htvA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1

(Schizosaccharomyces
pombe) 		PF00498
(FHA) 		5 MET A 233
LEU A 226
LEU A 243
ILE A 310
THR A 236
 None
 1.27A 4f4dA-3i0mA:
undetectable		 4f4dA-3i0mA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 U2 SMALL NUCLEAR
RIBONUCLEOPROTEIN A'

(Schizosaccharomyces
pombe) 		PF01423
(LSM) 		5 LEU j 108
LEU j 117
LEU j 144
ILE j  78
VAL j 124
 None
 1.20A 4f4dA-3jb9j:
undetectable		 4f4dA-3jb9j:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbl NLR FAMILY CARD
DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		no annotation 5 LEU K 796
LEU K 768
LEU K 741
ILE K 811
THR K 733
 None
 1.25A 4f4dA-3jblK:
undetectable		 4f4dA-3jblK:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv0 HET-C2

(Podospora
anserina) 		PF08718
(GLTP) 		5 MET A  67
LEU A 197
ILE A  88
THR A  49
VAL A  26
 None
MLY  A 198 ( 4.3A)
None
MLY  A  64 ( 4.3A)
None
 1.18A 4f4dA-3kv0A:
undetectable		 4f4dA-3kv0A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR

(Pseudomonas
putida) 		PF00532
(Peripla_BP_1) 		5 LEU A 239
LEU A 268
ILE A 233
GLN A 230
THR A 272
 None
 1.12A 4f4dA-3o75A:
4.3		 4f4dA-3o75A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pet PUTATIVE ADHESIN

(Bacteroides
fragilis) 		PF10988
(DUF2807) 		5 LEU A 113
LEU A 135
LEU A 155
ILE A  47
VAL A 145
 None
 1.21A 4f4dA-3petA:
undetectable		 4f4dA-3petA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A1276
LEU A1280
LEU A1281
THR A1181
VAL A1341
 None
 1.15A 4f4dA-3plsA:
undetectable		 4f4dA-3plsA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbt RAS-RELATED PROTEIN
RAB-8A

(Homo sapiens) 		PF00071
(Ras) 		5 LEU A  59
LEU A  11
LEU A  13
ARG A  48
ILE A  50
 None
 1.22A 4f4dA-3qbtA:
3.2		 4f4dA-3qbtA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm3 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Campylobacter
jejuni) 		PF01116
(F_bP_aldolase) 		5 LEU A 159
LEU A 166
LEU A 204
ILE A 118
ARG A 108
 None
 1.24A 4f4dA-3qm3A:
undetectable		 4f4dA-3qm3A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp. PCC 7002) 		PF00933
(Glyco_hydro_3) 		5 MET A 307
LEU A 273
LEU A 144
ILE A 339
GLN A  20
 ACY  A 548 ( 4.7A)
None
ACY  A 548 ( 4.6A)
None
None
 1.21A 4f4dA-3sqlA:
undetectable		 4f4dA-3sqlA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		5 LEU A 115
LEU A 116
LEU A 153
ILE A  39
THR A 142
 None
 1.29A 4f4dA-3tqsA:
undetectable		 4f4dA-3tqsA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 LEU A 314
LEU A 311
ILE A 207
GLN A 204
THR A 108
 None
 1.28A 4f4dA-3ttfA:
undetectable		 4f4dA-3ttfA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un9 NLR FAMILY MEMBER X1

(Homo sapiens) 		PF13516
(LRR_6) 		5 LEU A 773
LEU A 770
LEU A 762
ILE A 781
THR A 817
 None
 1.25A 4f4dA-3un9A:
undetectable		 4f4dA-3un9A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvs PUTATIVE
MONOOXYGENASE

(Streptomyces
sp. SN-593) 		PF00067
(p450) 		5 MET A 397
LEU A 374
LEU A 377
LEU A 258
ILE A 129
 None
 1.27A 4f4dA-3wvsA:
undetectable		 4f4dA-3wvsA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)

(Sulfolobus
solfataricus) 		PF00266
(Aminotran_5) 		5 LEU A 199
LEU A 200
LEU A 223
GLN A 188
THR A  71
 None
None
None
PLP  A1189 (-3.4A)
None
 1.28A 4f4dA-3zrpA:
undetectable		 4f4dA-3zrpA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a29 ENGINEERED
RETRO-ALDOL ENZYME
RA95.0

(synthetic
construct) 		PF00218
(IGPS) 		5 LEU A 157
LEU A 108
ILE A 179
GLN A 194
THR A  83
 None
None
None
None
3NK  A 299 ( 4.5A)
 1.26A 4f4dA-4a29A:
undetectable		 4f4dA-4a29A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		5 LEU A  63
LEU A   8
LEU A  85
THR A 171
VAL A 117
 None
 1.19A 4f4dA-4acaA:
undetectable		 4f4dA-4acaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster) 		no annotation 5 LEU A 599
LEU A 596
LEU A 593
ILE A 554
THR A 648
 None
 0.96A 4f4dA-4bwpA:
undetectable		 4f4dA-4bwpA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cf3 L-HALOACID
DEHALOGENASE

(Rhodobacteraceae) 		PF00702
(Hydrolase) 		5 LEU A  26
LEU A  29
ILE A  51
THR A  98
VAL A  73
 None
 1.30A 4f4dA-4cf3A:
undetectable		 4f4dA-4cf3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA

(Streptococcus
pneumoniae) 		PF13306
(LRR_5) 		5 LEU A 342
LEU A 365
LEU A 386
ILE A 322
VAL A 358
 None
 1.10A 4f4dA-4cp6A:
undetectable		 4f4dA-4cp6A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13306
(LRR_5) 		5 LEU A 298
LEU A 319
LEU A 342
ILE A 278
VAL A 308
 None
 1.02A 4f4dA-4fs7A:
undetectable		 4f4dA-4fs7A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h4a MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE

(Drosophila
melanogaster) 		PF13091
(PLDc_2) 		5 MET A 151
LEU A 109
LYS A 171
ILE A 111
VAL A  93
 None
 1.29A 4f4dA-4h4aA:
undetectable		 4f4dA-4h4aA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4

(Saccharopolyspora
spinosa) 		PF08659
(KR) 		5 LEU A 149
LEU A 146
LEU A 144
ARG A 188
THR A 113
 None
 1.27A 4f4dA-4impA:
1.7		 4f4dA-4impA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN

(Chaetomium
thermophilum) 		PF00557
(Peptidase_M24) 		5 LEU A 191
LEU A 192
LEU A 225
ILE A 376
GLN A 379
 None
 1.22A 4f4dA-4ipaA:
undetectable		 4f4dA-4ipaA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j16 NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		5 LEU C 440
LEU C 443
LEU C 447
ILE C 374
VAL C 295
 None
 1.23A 4f4dA-4j16C:
undetectable		 4f4dA-4j16C:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9m RAS GUANYL-RELEASING
PROTEIN 1

(Homo sapiens) 		PF00130
(C1_1)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF13405
(EF-hand_6) 		5 LEU A 409
LEU A 413
LEU A 417
VAL A 281
ARG A 265
 None
 1.01A 4f4dA-4l9mA:
undetectable		 4f4dA-4l9mA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 LEU A 438
LEU A 463
LEU A 462
ILE A 509
THR A 455
 None
 1.22A 4f4dA-4m0mA:
2.6		 4f4dA-4m0mA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mag SIALIC ACID BINDING
PROTEIN

(Vibrio cholerae) 		PF03480
(DctP) 		5 LEU A  27
LEU A  37
LEU A  39
ILE A 232
VAL A 214
 None
 1.13A 4f4dA-4magA:
undetectable		 4f4dA-4magA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		5 LEU A 451
LEU A 411
ARG A 395
THR A 300
VAL A 393
 None
 1.28A 4f4dA-4n2cA:
undetectable		 4f4dA-4n2cA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmn REPLICATIVE DNA
HELICASE

(Aquifex
aeolicus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 LEU A 201
LEU A 341
LEU A 297
ILE A 203
ARG A 330
 None
 1.21A 4f4dA-4nmnA:
undetectable		 4f4dA-4nmnA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN

(Actinomyces
naeslundii) 		PF01844
(HNH) 		5 LEU A 409
LEU A 374
LEU A 420
ILE A 405
THR A 362
 None
 1.30A 4f4dA-4ogcA:
undetectable		 4f4dA-4ogcA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opw UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF10988
(DUF2807) 		5 LEU A 108
LEU A 130
LEU A 151
ILE A  44
VAL A 140
 None
 1.20A 4f4dA-4opwA:
undetectable		 4f4dA-4opwA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbc D-AMINO ACID
AMINOTRANSFERASE

(Burkholderia
cenocepacia) 		PF01063
(Aminotran_4) 		5 LEU A  71
LEU A  74
LEU A  78
ILE A  96
THR A 119
 None
 1.22A 4f4dA-4pbcA:
undetectable		 4f4dA-4pbcA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5q GLUTATHIONE
S-TRANSFERASE

(Dermatophagoides
pteronyssinus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 MET A 108
LEU A 129
LEU A 132
LEU A 136
THR A 105
 None
 1.15A 4f4dA-4q5qA:
undetectable		 4f4dA-4q5qA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudarthrobacter
chlorophenolicus) 		PF01547
(SBP_bac_1) 		5 LEU A 140
LEU A 350
LEU A 353
ILE A 137
VAL A 153
 None
 1.24A 4f4dA-4r2fA:
undetectable		 4f4dA-4r2fA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s38 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF04551
(GcpE) 		5 LEU A 251
LEU A 247
LEU A 211
ILE A  24
THR A 231
 None
 1.24A 4f4dA-4s38A:
undetectable		 4f4dA-4s38A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzh LIC12234

(Leptospira
interrogans) 		PF13855
(LRR_8) 		5 LEU A 187
LEU A 193
ILE A 209
GLN A 207
THR A 148
 None
 0.93A 4f4dA-4tzhA:
undetectable		 4f4dA-4tzhA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsh UROPORPHYRINOGEN
DECARBOXYLASE

(Pseudomonas
aeruginosa) 		PF01208
(URO-D) 		5 LEU A  13
LEU A  10
LEU A   4
ILE A 247
GLN A 206
 None
 1.09A 4f4dA-4wshA:
undetectable		 4f4dA-4wshA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6

(Saccharomyces
cerevisiae) 		PF09295
(ChAPs) 		5 LEU B 315
LEU B 312
LEU B 308
THR B 344
VAL B 246
 None
 1.21A 4f4dA-4yg8B:
undetectable		 4f4dA-4yg8B:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)

(Homo sapiens) 		no annotation 5 LEU A 420
LEU A 450
LEU A 467
ILE A 407
THR A 462
 None
None
None
None
GOL  A 504 (-3.5A)
 1.15A 4f4dA-4z79A:
undetectable		 4f4dA-4z79A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)

(Homo sapiens) 		no annotation 5 LEU A 420
LEU A 450
LEU A 467
ILE A 407
THR A 462
 None
 1.15A 4f4dA-4z8gA:
undetectable		 4f4dA-4z8gA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin) 		5 LEU G1420
LEU G1450
LEU G1467
ILE G1407
THR G1462
 None
 1.11A 4f4dA-4z94G:
undetectable		 4f4dA-4z94G:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zad FDC1

(Candida
dubliniensis) 		PF01977
(UbiD) 		5 LEU A 378
LEU A 381
ILE A 373
HIS A 348
VAL A 392
 None
 1.22A 4f4dA-4zadA:
undetectable		 4f4dA-4zadA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr8 UROPORPHYRINOGEN
DECARBOXYLASE

(Acinetobacter
baumannii) 		PF01208
(URO-D) 		5 LEU A  13
LEU A  10
LEU A   4
ILE A 246
GLN A 205
 None
 1.12A 4f4dA-4zr8A:
undetectable		 4f4dA-4zr8A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a30 MITOCHONDRIAL
PROTEIN

(Gallus gallus) 		PF03828
(PAP_assoc) 		5 LEU A 174
LEU A 520
LEU A 435
ILE A 171
HIS A 358
 None
 1.26A 4f4dA-5a30A:
undetectable		 4f4dA-5a30A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		5 LEU A1811
LEU A1771
LEU A1772
ILE A1815
ARG A1981
 None
 1.29A 4f4dA-5fbyA:
undetectable		 4f4dA-5fbyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		5 LEU A 428
LEU A 431
LEU A 435
ILE A 345
THR A 387
 None
 0.81A 4f4dA-5g4iA:
undetectable		 4f4dA-5g4iA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		5 LEU A 428
LEU A 431
LEU A 435
THR A 387
VAL A 362
 None
 1.06A 4f4dA-5g4iA:
undetectable		 4f4dA-5g4iA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta) 		PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A 129
LEU A 150
LEU A 171
ILE A  94
ARG A 473
 None
 1.00A 4f4dA-5gmhA:
undetectable		 4f4dA-5gmhA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5he9 HELICASE LOADER
PHAGE INHIBITOR
PROTEIN

(Staphylococcus
aureus;
Staphylococcus
aureus) 		PF01695
(IstB_IS21)
no annotation 		5 LEU E  32
LEU E  35
ILE E  22
GLN E  19
THR A 168
 None
None
None
None
ADP  A 401 (-4.3A)
 1.23A 4f4dA-5he9E:
undetectable		 4f4dA-5he9E:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		5 LEU A 452
LEU A 412
ARG A 396
THR A 297
VAL A 394
 None
 1.26A 4f4dA-5hp5A:
undetectable		 4f4dA-5hp5A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htp PROBABLE SUGAR
KINASE

(Synechococcus
elongatus) 		PF02782
(FGGY_C) 		5 LEU A 345
LEU A 342
LEU A 296
ARG A 334
THR A 291
 None
 1.18A 4f4dA-5htpA:
undetectable		 4f4dA-5htpA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7k BPI FOLD-CONTAINING
FAMILY A MEMBER 1

(Homo sapiens) 		PF01273
(LBP_BPI_CETP) 		5 LEU A  55
LEU A 118
ILE A 242
THR A 160
VAL A 253
 None
 1.26A 4f4dA-5i7kA:
undetectable		 4f4dA-5i7kA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh1 ALDOSE REDUCTASE,
AKR4C7

(Zea mays) 		PF00248
(Aldo_ket_red) 		5 LEU A  62
LEU A  59
LEU A 100
THR A  76
VAL A  28
 None
 1.24A 4f4dA-5jh1A:
undetectable		 4f4dA-5jh1A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpq ES7

(Chaetomium
thermophilum) 		PF01798
(Nop) 		5 LEU s  80
LEU s  84
LEU s  88
ILE s  40
VAL s  45
 None
 1.30A 4f4dA-5jpqs:
undetectable		 4f4dA-5jpqs:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrj PROTEIN RECA

(Herbaspirillum
seropedicae) 		PF00154
(RecA) 		5 LEU A  84
LEU A 114
ILE A 199
GLN A 201
THR A 109
 None
None
None
ATP  A 402 (-3.0A)
None
 1.04A 4f4dA-5jrjA:
undetectable		 4f4dA-5jrjA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxf MACROPHAGE
COLONY-STIMULATING
FACTOR 1

(Homo sapiens) 		PF05337
(CSF-1) 		5 LEU A  22
LEU A  19
LEU A  16
ILE A  77
THR A 124
 None
 1.07A 4f4dA-5lxfA:
undetectable		 4f4dA-5lxfA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0l RETICULON-4 RECEPTOR

(Mus musculus) 		no annotation 5 LEU A  83
LEU A 107
LEU A 129
ILE A  62
VAL A  72
 None
 1.01A 4f4dA-5o0lA:
undetectable		 4f4dA-5o0lA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6b ATP-DEPENDENT DNA
HELICASE PIF1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 267
LEU A 237
ILE A 374
GLN A 372
VAL A 274
 None
ADP  A1001 ( 4.9A)
None
None
None
 1.07A 4f4dA-5o6bA:
undetectable		 4f4dA-5o6bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suj UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 LEU A 167
LEU A 147
LEU A 206
LYS A 190
GLN A 193
 None
 1.28A 4f4dA-5sujA:
undetectable		 4f4dA-5sujA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 LEU A 508
LEU A 451
LEU A 466
ILE A 617
GLN A 706
 None
 1.18A 4f4dA-5tusA:
undetectable		 4f4dA-5tusA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		5 LEU A  25
LEU A  21
LEU A  17
ARG A  28
ILE A   3
 None
None
NAP  A 300 (-4.5A)
None
None
 1.26A 4f4dA-5u4sA:
undetectable		 4f4dA-5u4sA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxl INVASIN IPAD

(Shigella
flexneri) 		PF06511
(IpaD) 		5 LEU A 257
LEU A 260
LEU A 190
ILE A 253
VAL A 170
 None
 1.26A 4f4dA-5vxlA:
undetectable		 4f4dA-5vxlA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7c ACYLOXYACYL
HYDROLASE
ACYLOXYACYL
HYDROLASE

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 LEU C 288
LEU A  73
ILE C 270
THR A  82
VAL A  50
 None
None
FTT  C 611 (-3.9A)
None
FTT  C 611 ( 4.3A)
 1.21A 4f4dA-5w7cC:
3.0		 4f4dA-5w7cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x18 CASEIN KINASE I
HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A 149
LEU A 152
LEU A 355
ILE A 207
GLN A 171
 None
 1.26A 4f4dA-5x18A:
undetectable		 4f4dA-5x18A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xne -

(-) 		no annotation 5 LEU B  32
LEU B  31
LEU B  59
ILE B 247
HIS B 193
 None
None
None
None
ZN  B 301 (-3.4A)
 1.17A 4f4dA-5xneB:
undetectable		 4f4dA-5xneB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE

(Saccharomyces
cerevisiae) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		5 LEU A 991
LEU A1083
ARG A 985
ILE A 981
GLN A 978
 None
 1.16A 4f4dA-5xvmA:
1.5		 4f4dA-5xvmA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z24 PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 5 LEU A 436
LEU A 431
ILE A 409
THR A 378
VAL A 397
 None
 1.25A 4f4dA-5z24A:
undetectable		 4f4dA-5z24A:
undetectable