SIMILAR PATTERNS OF AMINO ACIDS FOR 4F3T_A_IPHA902_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad9 IGG CTM01 FAB (LIGHT
CHAIN)

(Homo sapiens) 		no annotation 4 LEU L  27
LYS L  27
LEU L  92
GLU L  93
 None
 0.74A 4f3tA-1ad9L:
undetectable		 4f3tA-1ad9L:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF02463
(SMC_N) 		4 LEU A1110
TYR A1113
LEU A1083
GLU A1080
 None
 1.18A 4f3tA-1e69A:
undetectable		 4f3tA-1e69A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A  58
LYS A  56
LEU A 191
GLU A 190
 None
FAD  A 462 (-3.4A)
None
None
 1.19A 4f3tA-1ebdA:
undetectable		 4f3tA-1ebdA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A 114
TYR A 137
LYS A 135
GLU A 112
 None
 1.19A 4f3tA-1h6dA:
4.9		 4f3tA-1h6dA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jig DLP-2

(Bacillus
anthracis) 		PF00210
(Ferritin) 		4 LEU A  21
TYR A  54
LEU A 105
TYR A 102
 None
 1.01A 4f3tA-1jigA:
undetectable		 4f3tA-1jigA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		4 LEU A 249
LYS A 358
LEU A 282
GLU A 279
 HEM  A 410 ( 4.3A)
None
None
None
 1.15A 4f3tA-1jioA:
undetectable		 4f3tA-1jioA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF02548
(Pantoate_transf) 		4 LEU A 213
LYS A 231
GLU A 250
TYR A 256
 None
 0.96A 4f3tA-1m3uA:
0.0		 4f3tA-1m3uA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9b ADENYLOSUCCINATE
SYNTHETASE

(Plasmodium
falciparum) 		PF00709
(Adenylsucc_synt) 		4 LEU A 343
LYS A 339
LEU A 298
GLU A 304
 None
GDP  A1603 (-2.9A)
None
None
 1.14A 4f3tA-1p9bA:
undetectable		 4f3tA-1p9bA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		4 LEU A 465
TYR A 397
LEU A 380
TYR A 477
 None
 1.16A 4f3tA-1px8A:
0.9		 4f3tA-1px8A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyi HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF13242
(Hydrolase_like) 		4 LEU A 176
LEU A  29
GLU A  28
TYR A  35
 None
 1.19A 4f3tA-1qyiA:
2.3		 4f3tA-1qyiA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjj ACTININ

(Gallus gallus) 		PF00307
(CH)
PF00435
(Spectrin)
PF08726
(EFhand_Ca_insen) 		4 LEU A  69
LYS A  65
LEU A  46
GLU A  54
 None
 1.14A 4f3tA-1sjjA:
undetectable		 4f3tA-1sjjA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woy METHIONYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF09334
(tRNA-synt_1g) 		4 LEU A 320
LYS A 314
LEU A 341
GLU A 338
 None
 1.16A 4f3tA-1woyA:
2.2		 4f3tA-1woyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xgy K42-41L FAB LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L  27
LYS L  27
LEU L  92
GLU L  93
 None
 0.99A 4f3tA-1xgyL:
undetectable		 4f3tA-1xgyL:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esf CARBONIC ANHYDRASE 2

(Escherichia
coli) 		PF00484
(Pro_CA) 		4 LEU A 134
LYS A 129
LEU A 149
GLU A 153
 None
 1.02A 4f3tA-2esfA:
3.4		 4f3tA-2esfA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fsr ACETYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13302
(Acetyltransf_3) 		4 LEU A  93
TYR A 130
LEU A 127
TYR A 165
 None
 1.16A 4f3tA-2fsrA:
undetectable		 4f3tA-2fsrA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq4 HYPOTHETICAL PROTEIN
PH1570

(Pyrococcus
horikoshii) 		PF09638
(Ph1570) 		4 LEU A  35
TYR A  39
LEU A  65
GLU A  66
 None
 0.99A 4f3tA-2hq4A:
undetectable		 4f3tA-2hq4A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxj HISTONE DEMETHYLASE
JARID1A

(Homo sapiens) 		PF01388
(ARID) 		4 LEU A 120
TYR A 118
LEU A 166
GLU A 170
 None
 1.18A 4f3tA-2jxjA:
undetectable		 4f3tA-2jxjA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pae DTDP-6-DEOXY-3,4-KET
O-HEXULOSE ISOMERASE

(Aneurinibacillus
thermoaerophilus) 		PF05523
(FdtA) 		4 LEU A  87
TYR A  88
LYS A   4
LEU A  69
 None
 1.15A 4f3tA-2paeA:
undetectable		 4f3tA-2paeA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2za8 FERRITIN LIGHT CHAIN

(Equus caballus) 		PF00210
(Ferritin) 		4 TYR A  24
LYS A  59
LEU A 103
GLU A 104
 None
 0.89A 4f3tA-2za8A:
undetectable		 4f3tA-2za8A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuf ARGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 LEU A 240
TYR A 241
LEU A 235
TYR A 176
 None
 1.07A 4f3tA-2zufA:
3.5		 4f3tA-2zufA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adr PUTATIVE
UNCHARACTERIZED
PROTEIN ST1585

(Sulfurisphaera
tokodaii) 		PF00753
(Lactamase_B) 		4 LEU A 142
TYR A 144
LYS A  81
GLU A 128
 None
 1.06A 4f3tA-3adrA:
undetectable		 4f3tA-3adrA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg1 UPF0100 PROTEIN
PF0080

(Pyrococcus
furiosus) 		PF13531
(SBP_bac_11) 		4 LEU A 145
TYR A 142
LEU A 185
GLU A 184
 None
 1.20A 4f3tA-3cg1A:
2.2		 4f3tA-3cg1A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dad FH1/FH2
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 4 LEU A  45
LYS A  14
LEU A  88
GLU A  89
 None
 1.20A 4f3tA-3dadA:
undetectable		 4f3tA-3dadA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg8 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1) 		4 LEU A 174
LYS A 177
GLU A 204
TYR A 205
 None
 1.08A 4f3tA-3dg8A:
undetectable		 4f3tA-3dg8A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0o PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRB

(Bacillus
subtilis) 		PF01641
(SelR) 		4 LEU A  41
LEU A 129
GLU A 132
TYR A 134
 None
 1.16A 4f3tA-3e0oA:
undetectable		 4f3tA-3e0oA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  35
LYS A  37
LEU A 360
GLU A 357
 None
 1.17A 4f3tA-3eezA:
undetectable		 4f3tA-3eezA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0h AMINOTRANSFERASE

([Eubacterium]
rectale) 		PF00266
(Aminotran_5) 		4 LEU A 248
LYS A 252
GLU A  44
TYR A  45
 None
 1.12A 4f3tA-3f0hA:
undetectable		 4f3tA-3f0hA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Homo sapiens) 		PF00149
(Metallophos)
PF08321
(PPP5) 		4 LEU A 213
LYS A 217
LEU A 330
GLU A 333
 None
 1.12A 4f3tA-3h68A:
undetectable		 4f3tA-3h68A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		4 LEU A 565
TYR A 563
LYS A 560
GLU A 203
 None
 1.12A 4f3tA-3hs0A:
undetectable		 4f3tA-3hs0A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Colwellia
psychrerythraea) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A  54
LYS A  52
LEU A 186
GLU A 185
 None
FAD  A 490 (-3.1A)
None
None
 1.06A 4f3tA-3ic9A:
undetectable		 4f3tA-3ic9A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Enterococcus
faecalis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 124
TYR A 122
LEU A 321
GLU A 182
 None
 1.03A 4f3tA-3il4A:
2.1		 4f3tA-3il4A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jx9 PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE

(Exiguobacterium
sibiricum) 		PF10740
(DUF2529) 		4 LEU A  42
TYR A  41
LEU A  55
TYR A  52
 None
 1.13A 4f3tA-3jx9A:
undetectable		 4f3tA-3jx9A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k32 UNCHARACTERIZED
PROTEIN MJ0690

(Methanocaldococcus
jannaschii) 		no annotation 4 LEU A  92
LEU A 123
GLU A 124
TYR A 131
 None
 1.07A 4f3tA-3k32A:
2.5		 4f3tA-3k32A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT

(Methanosarcina
mazei) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 LEU A 297
LEU A 212
GLU A 209
TYR A 208
 None
 1.00A 4f3tA-3khkA:
undetectable		 4f3tA-3khkA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis) 		PF00590
(TP_methylase) 		4 LEU A 160
LEU A 167
GLU A 165
TYR A 141
 None
 0.99A 4f3tA-3kwpA:
undetectable		 4f3tA-3kwpA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA

(Homo sapiens) 		PF00041
(fn3)
PF06328
(Lep_receptor_Ig)
PF09240
(IL6Ra-bind) 		4 LEU A 392
TYR A 374
LEU A 327
TYR A 312
 None
 1.19A 4f3tA-3l5hA:
undetectable		 4f3tA-3l5hA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5j INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA

(Homo sapiens) 		PF00041
(fn3) 		4 LEU A 392
TYR A 374
LEU A 327
TYR A 312
 None
 1.14A 4f3tA-3l5jA:
undetectable		 4f3tA-3l5jA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntt CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
B) 		PF00740
(Parvo_coat) 		4 LEU A 341
TYR A 343
LEU A 637
TYR A 366
 None
 1.21A 4f3tA-3nttA:
undetectable		 4f3tA-3nttA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oev PROTEASOME COMPONENT
C1

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 LEU F  88
LEU F 116
GLU F  95
TYR F 119
 None
 1.20A 4f3tA-3oevF:
undetectable		 4f3tA-3oevF:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 LEU A 303
TYR A 304
LEU A 223
TYR A 222
 None
 0.77A 4f3tA-3qr1A:
2.6		 4f3tA-3qr1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ra2 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 LEU A 353
TYR A 355
LEU A 650
TYR A 378
 None
 1.15A 4f3tA-3ra2A:
undetectable		 4f3tA-3ra2A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rnl SULFOTRANSFERASE

(Alicyclobacillus
acidocaldarius) 		PF13469
(Sulfotransfer_3) 		4 LEU A 155
TYR A 152
LEU A 127
GLU A 133
 GOL  A 313 (-3.9A)
None
None
None
 1.18A 4f3tA-3rnlA:
4.3		 4f3tA-3rnlA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rx8 CELLULASE

(Alicyclobacillus
acidocaldarius) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 LEU A  64
TYR A  16
LEU A  36
TYR A  70
 None
 1.06A 4f3tA-3rx8A:
undetectable		 4f3tA-3rx8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tad LIPRIN-ALPHA-2

(Homo sapiens) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		4 LEU A 909
TYR A1016
LEU A 885
GLU A 886
 None
 1.07A 4f3tA-3tadA:
undetectable		 4f3tA-3tadA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpx LEUCINE
DEHYDROGENASE

(Sporosarcina
psychrophila) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 TYR A 156
LYS A 159
LEU A 192
GLU A 195
 None
 1.20A 4f3tA-3vpxA:
3.5		 4f3tA-3vpxA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwa CYTOPLASMIC EXPORT
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 488
LEU A 526
GLU A 529
TYR A 530
 None
 1.05A 4f3tA-3vwaA:
undetectable		 4f3tA-3vwaA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROBABLE PROTEASOME
SUBUNIT ALPHA TYPE-7

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 LEU G  87
LEU G 115
GLU G  94
TYR G 118
 None
 1.20A 4f3tA-3wxrG:
2.3		 4f3tA-3wxrG:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czd PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ASNC
FAMILY
PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ASNC
FAMILY

(Desulfovibrio
desulfuricans;
Desulfovibrio
desulfuricans) 		PF13404
(HTH_AsnC-type)
no annotation 		4 LEU A  40
LEU B  42
GLU B  38
TYR B  27
 None
 1.06A 4f3tA-4czdA:
undetectable		 4f3tA-4czdA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 126
LYS A 130
LEU A 271
GLU A 268
 None
 1.15A 4f3tA-4fg8A:
undetectable		 4f3tA-4fg8A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 4 LEU A 294
TYR A 378
LYS A 290
GLU A 535
 None
 1.16A 4f3tA-4fyeA:
undetectable		 4f3tA-4fyeA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga2 E3 SUMO-PROTEIN
LIGASE RANBP2

(Pan troglodytes) 		PF00515
(TPR_1) 		4 LEU A  66
LEU A  69
GLU A  73
TYR A  70
 None
 1.18A 4f3tA-4ga2A:
undetectable		 4f3tA-4ga2A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyv FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF00621
(RhoGEF) 		4 LEU A 557
LEU A 554
GLU A 550
TYR A 553
 None
 1.08A 4f3tA-4gyvA:
undetectable		 4f3tA-4gyvA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 LEU A 559
LEU A 556
GLU A 552
TYR A 555
 None
 1.13A 4f3tA-4h6yA:
undetectable		 4f3tA-4h6yA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

([Eubacterium]
eligens) 		PF01497
(Peripla_BP_2) 		4 LEU A 288
LEU A 262
GLU A 259
TYR A 258
 None
 1.20A 4f3tA-4hn9A:
2.6		 4f3tA-4hn9A:
18.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		4 LEU A 648
TYR A 652
LEU A 692
TYR A 696
 None
 0.37A 4f3tA-4krfA:
64.3		 4f3tA-4krfA:
82.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 LEU A 199
TYR A 231
LYS A 229
GLU A 196
 None
 1.21A 4f3tA-4m0mA:
3.1		 4f3tA-4m0mA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdg PUTATIVE ADHESIN

(Bacteroides
thetaiotaomicron) 		PF08842
(Mfa2) 		4 LEU A  66
LEU A  88
GLU A  87
TYR A  93
 None
 1.20A 4f3tA-4qdgA:
undetectable		 4f3tA-4qdgA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8h CRYPTOCHROME-2

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 LEU A 290
TYR A 291
LYS A 295
GLU A 253
 None
 1.11A 4f3tA-4u8hA:
undetectable		 4f3tA-4u8hA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw9 BETA-PHOSPHOGLUCOMUT
ASE

(Pyrococcus sp.
ST04) 		PF13419
(HAD_2) 		4 LEU A 195
TYR A 197
LEU A 216
GLU A 215
 None
 1.11A 4f3tA-4uw9A:
undetectable		 4f3tA-4uw9A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk5 GERANYLTRANSTRANSFER
ASE

(Thermotoga
neapolitana) 		PF00348
(polyprenyl_synt) 		4 LEU A 262
LYS A 266
LEU A 247
TYR A 243
 None
 1.05A 4f3tA-4wk5A:
undetectable		 4f3tA-4wk5A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woy MITOCHONDRIAL
DYNAMICS PROTEIN
MID49

(Mus musculus) 		PF03281
(Mab-21) 		4 LEU A 443
TYR A 441
LEU A 412
GLU A 413
 None
 1.13A 4f3tA-4woyA:
undetectable		 4f3tA-4woyA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zda ISOCITRATE
DEHYDROGENASE (NADP)
ICD2

(Mycolicibacterium
smegmatis) 		PF03971
(IDH) 		4 LEU A  51
LEU A 102
GLU A 101
TYR A 720
 None
 1.16A 4f3tA-4zdaA:
2.8		 4f3tA-4zdaA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		4 LEU A 427
TYR A 174
LEU A 431
GLU A 432
 None
 1.18A 4f3tA-4zhjA:
3.8		 4f3tA-4zhjA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avp L-RIBOSE ISOMERASE

(Geodermatophilus
obscurus) 		no annotation 4 LEU A  94
TYR A 212
LEU A  73
GLU A  71
 None
 1.15A 4f3tA-5avpA:
undetectable		 4f3tA-5avpA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6a PYRIDOXAL KINASE
PDXY

(Pseudomonas
aeruginosa) 		PF08543
(Phos_pyr_kin) 		4 LEU A 110
TYR A 111
LEU A 232
TYR A 144
 None
 0.94A 4f3tA-5b6aA:
3.2		 4f3tA-5b6aA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by6 THYMIDYLATE SYNTHASE

(Trichinella
spiralis) 		PF00303
(Thymidylat_synt) 		4 LEU A  30
LEU A  27
GLU A  23
TYR A  26
 None
 1.18A 4f3tA-5by6A:
undetectable		 4f3tA-5by6A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs0 ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		4 LEU A 838
TYR A 840
LEU A 918
TYR A 914
 None
 0.92A 4f3tA-5cs0A:
undetectable		 4f3tA-5cs0A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00364
(Biotin_lipoyl)
PF08326
(ACC_central) 		4 LEU A 838
TYR A 840
LEU A 918
TYR A 914
 None
 1.00A 4f3tA-5csaA:
undetectable		 4f3tA-5csaA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 LEU A 838
TYR A 840
LEU A 918
TYR A 914
 None
 1.05A 4f3tA-5cslA:
3.0		 4f3tA-5cslA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dq6 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 3

(Mus musculus) 		PF02338
(OTU) 		4 LEU A 236
LEU A 302
GLU A 305
TYR A 306
 None
 1.18A 4f3tA-5dq6A:
undetectable		 4f3tA-5dq6A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7q ACYL-COA SYNTHETASE

(Streptomyces
platensis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A  42
LEU A 148
GLU A 145
TYR A 144
 None
 1.01A 4f3tA-5e7qA:
undetectable		 4f3tA-5e7qA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 LEU A 128
LYS A  85
LEU A 100
GLU A 103
 None
5RC  A4000 (-2.8A)
None
None
 1.14A 4f3tA-5es1A:
undetectable		 4f3tA-5es1A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey0 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Staphylococcus
aureus) 		no annotation 4 LEU B 179
TYR B 181
LEU B 253
GLU B 188
 None
 1.18A 4f3tA-5ey0B:
undetectable		 4f3tA-5ey0B:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC97

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		4 LEU A 119
TYR A 116
LEU A 146
GLU A 147
 None
 1.20A 4f3tA-5flzA:
undetectable		 4f3tA-5flzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3a ORF70

(Human
gammaherpesvirus
8) 		PF00303
(Thymidylat_synt) 		4 LEU A  61
LEU A  58
GLU A  54
TYR A  57
 None
 1.21A 4f3tA-5h3aA:
undetectable		 4f3tA-5h3aA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis;
Bacillus
subtilis) 		PF02463
(SMC_N)
PF02463
(SMC_N) 		4 LEU B1004
LYS B 999
LEU A 195
GLU A 199
 None
 0.99A 4f3tA-5h67B:
undetectable		 4f3tA-5h67B:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LEU A 310
LYS A  92
LEU A 290
GLU A 294
 None
 1.08A 4f3tA-5iy9A:
undetectable		 4f3tA-5iy9A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6q CELL WALL BINDING
PROTEIN CWP8

(Clostridioides
difficile) 		PF04122
(CW_binding_2) 		4 LEU A 223
TYR A 221
LYS A 216
GLU A 261
 None
 0.88A 4f3tA-5j6qA:
undetectable		 4f3tA-5j6qA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		4 LEU A 406
TYR A 404
LEU A 372
GLU A 369
 None
 1.12A 4f3tA-5k04A:
undetectable		 4f3tA-5k04A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdi PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 8

(Homo sapiens) 		no annotation 4 LEU A 412
LYS A 416
LEU A 501
GLU A 498
 None
 1.03A 4f3tA-5kdiA:
undetectable		 4f3tA-5kdiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Caenorhabditis
elegans) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 LEU A 170
TYR A 169
LEU A 195
GLU A 240
 None
 1.19A 4f3tA-5kgnA:
undetectable		 4f3tA-5kgnA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lg8 FERRITIN LIGHT CHAIN

(Homo sapiens) 		PF00210
(Ferritin) 		4 TYR A  27
LYS A  62
LEU A 106
GLU A 107
 None
 0.88A 4f3tA-5lg8A:
undetectable		 4f3tA-5lg8A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ok8 LPP20 LIPOPROTEIN

(Helicobacter
pylori) 		no annotation 4 LEU A 170
LYS A 165
LEU A 132
GLU A 136
 None
 1.20A 4f3tA-5ok8A:
undetectable		 4f3tA-5ok8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0i TRYPTOPHAN--TRNA
LIGASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		4 LEU A  16
TYR A  21
LEU A  66
TYR A  67
 None
 0.51A 4f3tA-5v0iA:
undetectable		 4f3tA-5v0iA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis) 		no annotation 4 LEU A 887
LYS A 865
LEU A 904
GLU A 903
 None
 1.06A 4f3tA-5ve8A:
undetectable		 4f3tA-5ve8A:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 5 LEU A 651
LYS A 661
LEU A 695
GLU A 696
TYR A 699
 None
 0.75A 4f3tA-5vm9A:
59.9		 4f3tA-5vm9A:
79.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 5 LEU A 651
TYR A 655
LYS A 661
LEU A 695
GLU A 696
 None
 0.90A 4f3tA-5vm9A:
59.9		 4f3tA-5vm9A:
79.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 6 LEU A 650
TYR A 654
LYS A 660
LEU A 694
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.83A 4f3tA-5weaA:
59.2		 4f3tA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN

(Pyrococcus
horikoshii) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 LEU A  44
LYS A  48
LEU A 132
GLU A 135
 None
 1.03A 4f3tA-5wu7A:
undetectable		 4f3tA-5wu7A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN

(Pyrococcus
horikoshii) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 LEU A 514
LEU A 496
GLU A 460
TYR A 492
 None
 1.14A 4f3tA-5wu7A:
undetectable		 4f3tA-5wu7A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6v RAS-RELATED
GTP-BINDING PROTEIN
C

(Mus musculus) 		no annotation 4 LEU G 260
TYR G 268
LEU G 246
GLU G 243
 None
ACT  G 401 (-4.5A)
None
None
 1.03A 4f3tA-5x6vG:
undetectable		 4f3tA-5x6vG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zib -

(-) 		no annotation 4 LEU A 450
TYR A 452
LEU A 506
GLU A 526
 None
 1.07A 4f3tA-5zibA:
undetectable		 4f3tA-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zic -

(-) 		no annotation 4 LEU A 450
TYR A 452
LEU A 506
GLU A 526
 None
 1.17A 4f3tA-5zicA:
undetectable		 4f3tA-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER

(Enterococcus
casseliflavus) 		no annotation 4 LEU A 145
LYS A 140
LEU A  17
GLU A  13
 None
None
DMU  A 501 ( 4.8A)
None
 1.09A 4f3tA-6d0nA:
undetectable		 4f3tA-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
GAMMA-2,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT GAMMA-2

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 LEU A 272
TYR E 292
GLU A  52
TYR A 143
 None
 1.20A 4f3tA-6d6uA:
undetectable		 4f3tA-6d6uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfu TRYPTOPHAN--TRNA
LIGASE

(Haemophilus
influenzae) 		no annotation 4 LEU A  16
TYR A  21
LEU A  66
TYR A  67
 None
 0.76A 4f3tA-6dfuA:
undetectable		 4f3tA-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehr RAS-RELATED
GTP-BINDING PROTEIN
C

(Homo sapiens) 		PF04670
(Gtr1_RagA) 		4 LEU G 261
TYR G 269
LEU G 247
GLU G 244
 None
 1.07A 4f3tA-6ehrG:
undetectable		 4f3tA-6ehrG:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		no annotation 4 LEU A 561
LEU A 603
GLU A 605
TYR A 600
 None
 1.07A 4f3tA-6f91A:
undetectable		 4f3tA-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdt -

(-) 		no annotation 4 TYR A 349
LYS A 351
LEU A 379
GLU A 380
 None
 0.99A 4f3tA-6fdtA:
undetectable		 4f3tA-6fdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fgk GTP
PYROPHOSPHOKINASE
YWAC

(Bacillus
subtilis) 		no annotation 4 LEU A 134
TYR A 122
LYS A 120
GLU A 154
 None
 0.83A 4f3tA-6fgkA:
undetectable		 4f3tA-6fgkA:
undetectable