SIMILAR PATTERNS OF AMINO ACIDS FOR 4F3T_A_IPHA901
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c4o | DNA NUCLEOTIDEEXCISION REPAIRENZYME UVRB (Thermusthermophilus) |
PF00271(Helicase_C)PF04851(ResIII)PF12344(UvrB) | 4 | PHE A 324VAL A 133ALA A 57PHE A 3 | None | 1.47A | 4f3tA-1c4oA:undetectable | 4f3tA-1c4oA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f9k | ACIDIC LECTIN (Psophocarpustetragonolobus) |
PF00139(Lectin_legB) | 4 | PHE A 93VAL A 95ALA A 121PHE A 199 | None | 1.37A | 4f3tA-1f9kA:0.0 | 4f3tA-1f9kA:15.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gpz | COMPLEMENT C1RCOMPONENT (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 4 | PHE A 641VAL A 576ALA A 642PHE A 458 | None | 1.45A | 4f3tA-1gpzA:0.0 | 4f3tA-1gpzA:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1md7 | C1R COMPLEMENTSERINE PROTEASE (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 4 | PHE A 641VAL A 576ALA A 642PHE A 458 | None | 1.43A | 4f3tA-1md7A:0.0 | 4f3tA-1md7A:17.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q1q | SULFOTRANSFERASEFAMILY, CYTOSOLIC,2B, MEMBER 1 ISOFORMA (Homo sapiens) |
PF00685(Sulfotransfer_1) | 4 | PHE A 120VAL A 127ALA A 125PHE A 212 | None | 1.37A | 4f3tA-1q1qA:3.5 | 4f3tA-1q1qA:17.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j3m | PROLYL-TRNASYNTHETASE (Enterococcusfaecalis) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF04073(tRNA_edit) | 4 | PHE A 283VAL A 281ALA A 317PHE A 330 | None | 1.46A | 4f3tA-2j3mA:2.2 | 4f3tA-2j3mA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mzt | PROTEIN HRB1 (Saccharomycescerevisiae) |
PF00076(RRM_1) | 4 | PHE A 364VAL A 420ALA A 405PHE A 396 | None | 1.45A | 4f3tA-2mztA:2.7 | 4f3tA-2mztA:8.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qp4 | BILE SALTSULFOTRANSFERASE (Homo sapiens) |
PF00685(Sulfotransfer_1) | 4 | PHE A 109VAL A 116ALA A 114PHE A 201 | None | 1.30A | 4f3tA-2qp4A:3.2 | 4f3tA-2qp4A:15.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qqr | JMJCDOMAIN-CONTAININGHISTONEDEMETHYLATIONPROTEIN 3A (Homo sapiens) |
no annotation | 4 | PHE A 977VAL A 930ALA A 979PHE A 937 | None | 1.47A | 4f3tA-2qqrA:3.7 | 4f3tA-2qqrA:9.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y4f | PEROXIDASE YCDB (Escherichiacoli) |
PF04261(Dyp_perox) | 4 | PHE A 42VAL A 142ALA A 41PHE A 368 | None | 1.17A | 4f3tA-2y4fA:undetectable | 4f3tA-2y4fA:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a0f | XYLOGLUCANASE (Geotrichum sp.M128) |
no annotation | 4 | PHE A 527VAL A 498ALA A 515PHE A 479 | None | 1.46A | 4f3tA-3a0fA:undetectable | 4f3tA-3a0fA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dr2 | EXPORTEDGLUCONOLACTONASE (Xanthomonascampestris) |
PF08450(SGL) | 4 | PHE A 220VAL A 204ALA A 219PHE A 244 | None | 1.29A | 4f3tA-3dr2A:undetectable | 4f3tA-3dr2A:16.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7u | CYTOSINE-SPECIFICMETHYLTRANSFERASE (Escherichiacoli) |
PF00145(DNA_methylase) | 4 | PHE A 224VAL A 189ALA A 156PHE A 288 | None | 1.28A | 4f3tA-3g7uA:2.8 | 4f3tA-3g7uA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gfq | FMN-DEPENDENTNADPH-AZOREDUCTASE (Bacillussubtilis) |
PF03358(FMN_red) | 4 | PHE A 88VAL A 54ALA A 85PHE A 37 | None | 1.19A | 4f3tA-3gfqA:2.2 | 4f3tA-3gfqA:12.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k7u | ANTIBODY (Lama glama) |
PF07686(V-set) | 4 | PHE A 59VAL A 105ALA A 50PHE A 37 | None | 1.40A | 4f3tA-3k7uA:undetectable | 4f3tA-3k7uA:9.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kd6 | CARBOHYDRATE KINASE,PFKB FAMILY (Chlorobaculumtepidum) |
PF00294(PfkB) | 4 | PHE A 54VAL A 50ALA A 10PHE A 104 | NoneNoneAMP A 509 ( 3.8A)None | 1.38A | 4f3tA-3kd6A:undetectable | 4f3tA-3kd6A:16.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n0l | SERINEHYDROXYMETHYLTRANSFERASE (Campylobacterjejuni) |
PF00464(SHMT) | 4 | PHE A 193VAL A 217ALA A 194PHE A 212 | None | 1.13A | 4f3tA-3n0lA:2.0 | 4f3tA-3n0lA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s0m | OXALATEDECARBOXYLASE OXDC (Bacillussubtilis) |
PF00190(Cupin_1) | 4 | PHE A 155VAL A 82ALA A 80PHE A 52 | CO3 A 600 (-4.6A)NoneNoneNone | 1.45A | 4f3tA-3s0mA:undetectable | 4f3tA-3s0mA:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s98 | INTERFERONALPHA/BETA RECEPTOR1 (Homo sapiens) |
PF01108(Tissue_fac)PF09294(Interfer-bind) | 4 | PHE A 96VAL A 69ALA A 99PHE A 62 | None | 1.28A | 4f3tA-3s98A:undetectable | 4f3tA-3s98A:15.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f3n | UNCHARACTERIZED ACR,COG1565 SUPERFAMILY (Burkholderiathailandensis) |
PF02636(Methyltransf_28) | 4 | PHE A 273VAL A 188ALA A 272PHE A 185 | None | 1.41A | 4f3tA-4f3nA:undetectable | 4f3tA-4f3nA:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f4o | HAPTOGLOBIN (Sus scrofa) |
PF00089(Trypsin) | 4 | PHE C 300VAL C 222ALA C 301PHE C 114 | None | 1.49A | 4f3tA-4f4oC:undetectable | 4f3tA-4f4oC:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fir | PYRIDOXALBIOSYNTHESIS LYASEPDXS (Pyrococcushorikoshii) |
PF01680(SOR_SNZ)PF05690(ThiG) | 4 | PHE A 19VAL A 23ALA A 20PHE A 253 | None | 1.38A | 4f3tA-4firA:undetectable | 4f3tA-4firA:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fnv | HEPARINASE IIIPROTEIN, HEPARITINSULFATE LYASE (Bacteroidesthetaiotaomicron) |
PF07940(Hepar_II_III)PF16889(Hepar_II_III_N) | 4 | PHE A 675VAL A 687ALA A 685PHE A 554 | None | 1.46A | 4f3tA-4fnvA:undetectable | 4f3tA-4fnvA:23.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4krf | PROTEIN ARGONAUTE-1 (Homo sapiens) |
PF02170(PAZ)PF02171(Piwi)PF08699(ArgoL1)PF16486(ArgoN)PF16487(ArgoMid)PF16488(ArgoL2) | 4 | PHE A 585VAL A 589ALA A 618PHE A 651 | None | 0.21A | 4f3tA-4krfA:64.3 | 4f3tA-4krfA:82.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nx9 | FLAGELLIN (Pseudomonasaeruginosa) |
PF00669(Flagellin_N)PF00700(Flagellin_C) | 4 | PHE A 235VAL A 244ALA A 234PHE A 278 | None | 1.49A | 4f3tA-4nx9A:2.9 | 4f3tA-4nx9A:16.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rwe | SUGAR-BINDINGTRANSPORT PROTEIN (Yersinia pestis) |
PF13407(Peripla_BP_4) | 4 | PHE A 215VAL A 240ALA A 216PHE A 260 | None | 1.40A | 4f3tA-4rweA:7.2 | 4f3tA-4rweA:16.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tlh | ETHANOLAMINEUTILIZATION PROTEINEUTL (Clostridiumperfringens) |
PF00936(BMC) | 4 | PHE A 176VAL A 151ALA A 187PHE A 203 | None | 0.91A | 4f3tA-4tlhA:undetectable | 4f3tA-4tlhA:13.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wjg | HAPTOGLOBIN (Homo sapiens) |
no annotation | 4 | PHE C 355VAL C 277ALA C 356PHE C 169 | None | 1.47A | 4f3tA-4wjgC:undetectable | 4f3tA-4wjgC:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x0l | HAPTOGLOBIN (Homo sapiens) |
PF00089(Trypsin) | 4 | PHE C 359VAL C 281ALA C 360PHE C 173 | None | 1.46A | 4f3tA-4x0lC:undetectable | 4f3tA-4x0lC:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a8b | PTAUREO1A LOV2DOMAIN (Phaeodactylumtricornutum) |
PF13426(PAS_9) | 4 | PHE A 241VAL A 349ALA A 334PHE A 331 | NoneNoneNoneFMN A 500 (-3.7A) | 1.21A | 4f3tA-5a8bA:undetectable | 4f3tA-5a8bA:11.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bmo | PUTATIVEUNCHARACTERIZEDPROTEIN LNMX (Streptomycesatroolivaceus) |
PF02585(PIG-L) | 4 | PHE A 239VAL A 183ALA A 238PHE A 231 | None | 1.45A | 4f3tA-5bmoA:2.7 | 4f3tA-5bmoA:14.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cad | SM80.1 VICILIN (Solanummelongena) |
PF00190(Cupin_1) | 4 | PHE A 337VAL A 51ALA A 270PHE A 19 | None | 1.29A | 4f3tA-5cadA:undetectable | 4f3tA-5cadA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cb2 | PROTEIN SEY1 (Candidaalbicans) |
PF05879(RHD3) | 4 | PHE A 579VAL A 675ALA A 603PHE A 671 | None | 1.46A | 4f3tA-5cb2A:undetectable | 4f3tA-5cb2A:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kh5 | ISOPRENYLTRANSFERASE (Streptococcuspneumoniae) |
PF01255(Prenyltransf) | 4 | PHE A 143VAL A 69ALA A 144PHE A 210 | None | 1.46A | 4f3tA-5kh5A:undetectable | 4f3tA-5kh5A:14.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nkm | PROTEIN SMG-8 (Caenorhabditiselegans) |
PF10220(Smg8_Smg9) | 4 | PHE E 191VAL E 249ALA E 190PHE E 294 | None | 1.46A | 4f3tA-5nkmE:undetectable | 4f3tA-5nkmE:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ti1 | FUMARYLACETOACETATEHYDROLASE (Paraburkholderiaxenovorans) |
PF01557(FAA_hydrolase)PF09298(FAA_hydrolase_N) | 4 | PHE A 81VAL A 49ALA A 61PHE A 39 | None | 1.17A | 4f3tA-5ti1A:undetectable | 4f3tA-5ti1A:21.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vm9 | PROTEIN ARGONAUTE-3 (Homo sapiens) |
no annotation | 4 | PHE A 588VAL A 592ALA A 621PHE A 654 | None | 0.42A | 4f3tA-5vm9A:59.9 | 4f3tA-5vm9A:79.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wea | PROTEIN ARGONAUTE-2 (Homo sapiens) |
no annotation | 4 | PHE A 587VAL A 591ALA A 620PHE A 653 | None | 0.32A | 4f3tA-5weaA:59.2 | 4f3tA-5weaA:undetectable |