SIMILAR PATTERNS OF AMINO ACIDS FOR 4EYZ_A_CCSA109

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al8 GLYCOLATE OXIDASE

(Spinacia
oleracea) 		PF01070
(FMN_dh) 		4 VAL A 141
ILE A 152
SER A 224
ALA A 247
 None
 0.88A 4eyzA-1al8A:
0.0		 4eyzA-1al8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvy PROTEIN (CYTOCHROME
P450 BM-3)

(Bacillus
megaterium) 		PF00258
(Flavodoxin_1) 		4 ASN F 543
PHE F 547
VAL F 548
ALA F 493
 None
None
None
FMN  F1002 (-3.4A)
 0.94A 4eyzA-1bvyF:
undetectable		 4eyzA-1bvyF:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ei5 D-AMINOPEPTIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase)
PF07930
(DAP_B) 		4 ASN A 233
ILE A 309
SER A 231
ALA A  40
 None
 1.02A 4eyzA-1ei5A:
0.0		 4eyzA-1ei5A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ei6 PHOSPHONOACETATE
HYDROLASE

(Pseudomonas
fluorescens) 		PF01663
(Phosphodiest) 		4 ASN A 381
PHE A 226
ILE A  20
ALA A 402
 None
 0.90A 4eyzA-1ei6A:
0.0		 4eyzA-1ei6A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 PHE B 649
VAL B 483
HIS B 354
ILE B 355
ALA B 183
 None
 1.05A 4eyzA-1ffvB:
0.0		 4eyzA-1ffvB:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		4 VAL A 489
HIS A 562
ILE A 561
ALA A 519
 None
 0.96A 4eyzA-1fohA:
0.0		 4eyzA-1fohA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iaw TYPE II RESTRICTION
ENZYME NAEI

(Lechevalieria
aerocolonigenes) 		PF09126
(NaeI) 		4 VAL A 231
ILE A 248
SER A 239
ALA A 308
 None
 0.93A 4eyzA-1iawA:
0.0		 4eyzA-1iawA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 PHE A  62
VAL A  63
ILE A 121
ALA A 149
 None
 0.93A 4eyzA-1kfiA:
0.4		 4eyzA-1kfiA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kj9 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE 2

(Escherichia
coli) 		PF02222
(ATP-grasp) 		4 PHE A 200
VAL A 198
ILE A 276
ALA A 243
 ATP  A   1 (-4.9A)
ATP  A   1 (-3.9A)
None
None
 1.01A 4eyzA-1kj9A:
undetectable		 4eyzA-1kj9A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kj9 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE 2

(Escherichia
coli) 		PF02222
(ATP-grasp) 		4 PHE A 200
VAL A 198
ILE A 276
ALA A 247
 ATP  A   1 (-4.9A)
ATP  A   1 (-3.9A)
None
None
 0.99A 4eyzA-1kj9A:
undetectable		 4eyzA-1kj9A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0q SURFACE LAYER
PROTEIN

(Methanosarcina
mazei) 		PF00801
(PKD)
PF10282
(Lactonase) 		4 VAL A 112
ILE A 143
SER A  99
ALA A  80
 None
 0.94A 4eyzA-1l0qA:
undetectable		 4eyzA-1l0qA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lia R-PHYCOERYTHRIN
R-PHYCOERYTHRIN

(Polysiphonia
urceolata;
Polysiphonia
urceolata) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		4 ASN B  32
PHE B  30
ILE A  31
ALA A  35
 None
 0.98A 4eyzA-1liaB:
undetectable		 4eyzA-1liaB:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lry PEPTIDE DEFORMYLASE

(Pseudomonas
aeruginosa) 		PF01327
(Pep_deformylase) 		4 PHE A 143
VAL A 144
HIS A 137
ALA A  47
 None
None
ZN  A 168 ( 3.5A)
None
 0.92A 4eyzA-1lryA:
undetectable		 4eyzA-1lryA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A  18
VAL A  95
ILE A  49
ALA A 313
 None
None
None
FAD  A 459 (-3.5A)
 1.01A 4eyzA-1lvlA:
undetectable		 4eyzA-1lvlA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlx POLLEN ALLERGEN PHL
P 6

(Phleum pratense) 		PF01620
(Pollen_allerg_2) 		4 PHE A 491
VAL A 467
ILE A 498
SER A 492
 None
 1.00A 4eyzA-1nlxA:
undetectable		 4eyzA-1nlxA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogp SULFITE OXIDASE

(Arabidopsis
thaliana) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 VAL A 273
ILE A 270
SER A 285
ALA A 314
 None
 1.02A 4eyzA-1ogpA:
undetectable		 4eyzA-1ogpA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9o PHOSPHOPANTOTHENOYLC
YSTEINE SYNTHETASE

(Homo sapiens) 		PF04127
(DFP) 		4 VAL A 218
HIS A 252
ILE A 227
SER A 215
 None
 0.91A 4eyzA-1p9oA:
undetectable		 4eyzA-1p9oA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		4 ASN A  47
PHE A  48
ILE A  72
ALA A 103
 None
 1.01A 4eyzA-1pw4A:
undetectable		 4eyzA-1pw4A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 VAL A  67
ILE A  86
SER A 102
ALA A  91
 None
 0.96A 4eyzA-1rx0A:
undetectable		 4eyzA-1rx0A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szp DNA REPAIR PROTEIN
RAD51

(Saccharomyces
cerevisiae) 		PF08423
(Rad51)
PF14520
(HHH_5) 		4 VAL A  96
HIS A 105
ILE A  83
ALA A 266
 None
 1.01A 4eyzA-1szpA:
undetectable		 4eyzA-1szpA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tht THIOESTERASE

(Vibrio harveyi) 		PF02273
(Acyl_transf_2) 		4 PHE A 206
VAL A 257
ILE A 111
ALA A 120
 None
 1.01A 4eyzA-1thtA:
undetectable		 4eyzA-1thtA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 3
ARP2/3 COMPLEX 34KDA
SUBUNIT

(Bos taurus;
Bos taurus) 		PF00022
(Actin)
PF04045
(P34-Arc) 		4 ASN A  24
VAL D  31
HIS D  44
ILE D  45
 None
 0.87A 4eyzA-1u2vA:
undetectable		 4eyzA-1u2vA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		PF13476
(AAA_23)
no annotation 		4 PHE A  21
VAL A  19
ILE B 867
ALA B 863
 None
 0.99A 4eyzA-1us8A:
undetectable		 4eyzA-1us8A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhv DIPHTHINE SYNTHASE

(Archaeoglobus
fulgidus) 		PF00590
(TP_methylase) 		4 TYR A  34
HIS A  91
ILE A  94
ALA A  88
 None
 0.97A 4eyzA-1vhvA:
undetectable		 4eyzA-1vhvA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Thermotoga
maritima) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 VAL A 429
ILE A  26
SER A 434
ALA A 441
 None
 0.89A 4eyzA-1vrdA:
undetectable		 4eyzA-1vrdA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x48 INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Mus musculus) 		PF00035
(dsrm) 		4 ASN A  13
PHE A  15
ILE A  44
ALA A  64
 None
 0.67A 4eyzA-1x48A:
undetectable		 4eyzA-1x48A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhn RAS-RELATED PROTEIN
RAB-7

(Homo sapiens) 		PF00071
(Ras) 		4 TYR A  78
VAL A  85
ILE A  13
ALA A  43
 None
 0.96A 4eyzA-1yhnA:
undetectable		 4eyzA-1yhnA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp4 GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
SMALL SUBUNIT

(Solanum
tuberosum) 		PF00483
(NTP_transferase) 		4 VAL A  21
HIS A 159
ILE A 156
ALA A 164
 None
 1.00A 4eyzA-1yp4A:
undetectable		 4eyzA-1yp4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0v NUDIX HYDROLASE

(Nitrosomonas
europaea) 		PF00293
(NUDIX) 		4 VAL A  91
ILE A  13
SER A  51
ALA A  10
 None
 0.95A 4eyzA-2b0vA:
undetectable		 4eyzA-2b0vA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvl ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 PHE A 188
VAL A 205
ILE A 155
ALA A 200
 None
None
FAD  A1001 (-4.5A)
None
 1.01A 4eyzA-2dvlA:
undetectable		 4eyzA-2dvlA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		4 TYR A 797
ASN A 799
ILE A 850
ALA A 878
 None
 0.81A 4eyzA-2eaeA:
undetectable		 4eyzA-2eaeA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9

(Arabidopsis
thaliana) 		PF02204
(VPS9) 		4 VAL A 194
ILE A 166
SER A 135
ALA A 173
 None
 0.98A 4eyzA-2efeA:
undetectable		 4eyzA-2efeA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2euh NADP DEPENDENT NON
PHOSPHORYLATING
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Streptococcus
mutans) 		PF00171
(Aldedh) 		4 ASN A 227
VAL A 218
ILE A 238
ALA A 452
 None
 1.02A 4eyzA-2euhA:
undetectable		 4eyzA-2euhA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		4 PHE A 129
VAL A 130
ILE A  96
ALA A  48
 MPD  A 373 (-3.6A)
None
None
None
 1.02A 4eyzA-2g37A:
undetectable		 4eyzA-2g37A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		5 ASN A 481
PHE A 479
VAL A 452
HIS A 459
ALA A 673
 None
 1.35A 4eyzA-2gj4A:
undetectable		 4eyzA-2gj4A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A 288
ILE A 401
SER A 246
ALA A 207
 None
 0.97A 4eyzA-2i6tA:
undetectable		 4eyzA-2i6tA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00579
(tRNA-synt_1b) 		4 PHE A 440
VAL A 441
ILE A 367
ALA A 398
 None
 1.02A 4eyzA-2ip1A:
undetectable		 4eyzA-2ip1A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL

(Arabidopsis
thaliana) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 VAL A 100
HIS A 139
ILE A 136
ALA A 170
 None
 0.98A 4eyzA-2ix5A:
undetectable		 4eyzA-2ix5A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 ASN A1075
VAL A1070
ILE A1087
SER A1115
 None
 0.98A 4eyzA-2ix8A:
undetectable		 4eyzA-2ix8A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jv3 ETS1 PROTO-ONCOGENE

(Mus musculus) 		PF02198
(SAM_PNT) 		4 HIS A 128
ILE A 131
SER A  54
ALA A  84
 None
 0.92A 4eyzA-2jv3A:
undetectable		 4eyzA-2jv3A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k1g LIPOPROTEIN SPR

(Escherichia
coli) 		PF00877
(NLPC_P60) 		4 TYR A  56
PHE A  71
VAL A  72
HIS A 119
 None
 0.86A 4eyzA-2k1gA:
8.6		 4eyzA-2k1gA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kz2 CALMODULIN

(Gallus gallus) 		PF13499
(EF-hand_7) 		4 TYR A  99
ASN A 137
PHE A 141
VAL A 142
 None
CA  A 150 ( 4.6A)
None
None
 0.94A 4eyzA-2kz2A:
undetectable		 4eyzA-2kz2A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1g PUTATIVE XYLANASE

(Bacteroides
fragilis) 		PF07313
(DUF1460) 		4 TYR A  38
PHE A  63
VAL A  64
HIS A 208
 None
 0.52A 4eyzA-2p1gA:
8.1		 4eyzA-2p1gA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5

(Mus musculus) 		PF00400
(WD40) 		4 VAL B 182
ILE B 168
SER B 130
ALA B 110
 None
 0.98A 4eyzA-2pbiB:
undetectable		 4eyzA-2pbiB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfm ADENYLOSUCCINATE
LYASE

(Bacillus
anthracis) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 ASN A 327
PHE A 329
VAL A 333
ILE A 125
 None
 0.96A 4eyzA-2pfmA:
undetectable		 4eyzA-2pfmA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q09 IMIDAZOLONEPROPIONAS
E

(unidentified) 		PF01979
(Amidohydro_1) 		4 TYR A 235
VAL A 228
ILE A 194
ALA A 201
 None
 0.98A 4eyzA-2q09A:
undetectable		 4eyzA-2q09A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 ASN A 107
VAL A  83
ILE A 103
ALA A 475
 None
 1.02A 4eyzA-2v7gA:
undetectable		 4eyzA-2v7gA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vak SIGMA A

(Avian
orthoreovirus) 		PF03084
(Sigma_1_2) 		4 ASN A 177
VAL A 270
ILE A 242
ALA A 184
 None
 0.99A 4eyzA-2vakA:
undetectable		 4eyzA-2vakA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2var FRUCTOKINASE

(Sulfolobus
solfataricus) 		PF00294
(PfkB) 		5 TYR A 276
PHE A 264
VAL A 265
SER A 277
ALA A 304
 None
 1.47A 4eyzA-2varA:
undetectable		 4eyzA-2varA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn8 RETICULON-4-INTERACT
ING PROTEIN 1

(Homo sapiens) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 PHE A 220
VAL A 224
ILE A 192
ALA A 341
 None
 0.97A 4eyzA-2vn8A:
undetectable		 4eyzA-2vn8A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wba TRYPANOTHIONE
REDUCTASE

(Trypanosoma
brucei) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ASN A 133
VAL A 135
ILE A 156
SER A 131
 None
 1.01A 4eyzA-2wbaA:
undetectable		 4eyzA-2wbaA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqd PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Staphylococcus
aureus) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 TYR A 124
VAL A 114
ILE A 132
ALA A  77
 None
 1.02A 4eyzA-2wqdA:
undetectable		 4eyzA-2wqdA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		4 TYR A 248
ASN A 205
PHE A 207
SER A 208
 None
 0.98A 4eyzA-2yevA:
undetectable		 4eyzA-2yevA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv5 YJEQ PROTEIN

(Aquifex
aeolicus) 		PF03193
(RsgA_GTPase) 		4 TYR A  97
ASN A 101
ILE A 288
SER A 283
 None
 0.96A 4eyzA-2yv5A:
undetectable		 4eyzA-2yv5A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zk7 GLUCOSE
1-DEHYDROGENASE
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF13561
(adh_short_C2) 		4 ASN A 170
ILE A 159
SER A 126
ALA A 164
 None
 0.89A 4eyzA-2zk7A:
undetectable		 4eyzA-2zk7A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwt PROTEIN PUF4

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		4 ASN A 687
VAL A 678
HIS A 719
ILE A 716
 None
 0.98A 4eyzA-3bwtA:
undetectable		 4eyzA-3bwtA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 ASN A 481
PHE A 479
VAL A 452
HIS A 459
ALA A 673
 None
None
None
None
NBG  A   1 (-3.7A)
 1.41A 4eyzA-3cemA:
undetectable		 4eyzA-3cemA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clk TRANSCRIPTION
REGULATOR

(Lactobacillus
plantarum) 		PF13377
(Peripla_BP_3) 		4 VAL A 323
ILE A 165
SER A 288
ALA A 244
 None
 0.99A 4eyzA-3clkA:
undetectable		 4eyzA-3clkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2w TAR DNA-BINDING
PROTEIN 43

(Mus musculus) 		PF00076
(RRM_1) 		4 ASN A 259
PHE A 194
VAL A 195
ILE A 257
 None
 0.99A 4eyzA-3d2wA:
undetectable		 4eyzA-3d2wA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbg PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 VAL A 161
ILE A 283
SER A 276
ALA A 337
 None
 0.99A 4eyzA-3dbgA:
undetectable		 4eyzA-3dbgA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 PHE A 246
VAL A  39
ILE A  52
SER A 247
 None
 0.91A 4eyzA-3e77A:
undetectable		 4eyzA-3e77A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec7 PUTATIVE
DEHYDROGENASE

(Salmonella
enterica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 HIS A  79
ILE A  72
SER A  75
ALA A 100
 NAD  A 400 (-3.9A)
None
NAD  A 400 (-3.1A)
None
 1.00A 4eyzA-3ec7A:
undetectable		 4eyzA-3ec7A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emq ENDO-1,4-BETA-XYLANA
SE

(Paenibacillus
barcinonensis) 		PF00331
(Glyco_hydro_10) 		4 TYR A  59
VAL A 119
HIS A 114
ILE A 115
 None
 0.99A 4eyzA-3emqA:
undetectable		 4eyzA-3emqA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ew5 MACRO DOMAIN OF
NON-STRUCTURAL
PROTEIN 3

(Alphacoronavirus
1) 		PF01661
(Macro) 		4 TYR A  48
ASN A 183
PHE A 185
ILE A  56
 None
 0.79A 4eyzA-3ew5A:
undetectable		 4eyzA-3ew5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwx PEPTIDE DEFORMYLASE

(Vibrio cholerae) 		PF01327
(Pep_deformylase) 		4 PHE A 143
VAL A 144
HIS A 137
ALA A  48
 None
None
ZN  A 170 (-3.1A)
None
 0.96A 4eyzA-3fwxA:
undetectable		 4eyzA-3fwxA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyn INTEGRON GENE
CASSETTE PROTEIN
HFX_CASS3

(uncultured
bacterium) 		PF00583
(Acetyltransf_1) 		4 PHE A  86
VAL A  87
ILE A  55
ALA A   8
 None
ACT  A 202 ( 4.9A)
None
None
 0.80A 4eyzA-3fynA:
undetectable		 4eyzA-3fynA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8q PREDICTED
RNA-BINDING PROTEIN,
CONTAINS THUMP
DOMAIN

(Methanopyrus
kandleri) 		PF00383
(dCMP_cyt_deam_1)
PF02926
(THUMP) 		4 VAL A 222
ILE A 242
SER A 235
ALA A 231
 None
 0.87A 4eyzA-3g8qA:
undetectable		 4eyzA-3g8qA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grh ACYL-COA THIOESTER
HYDROLASE YBGC

(Escherichia
coli) 		PF01095
(Pectinesterase) 		4 ASN A 326
VAL A 329
SER A 318
ALA A 357
 None
 0.98A 4eyzA-3grhA:
undetectable		 4eyzA-3grhA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7n NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		PF11715
(Nup160) 		4 TYR A  56
ASN A  58
ILE A 463
SER A 461
 None
 0.98A 4eyzA-3h7nA:
undetectable		 4eyzA-3h7nA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7n NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		PF11715
(Nup160) 		4 TYR A  56
ASN A  58
VAL A 473
SER A 461
 None
 1.02A 4eyzA-3h7nA:
undetectable		 4eyzA-3h7nA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjz TRANSALDOLASE B

(Prochlorococcus
marinus) 		PF00923
(TAL_FSA) 		4 ASN A  35
ILE A  88
SER A  81
ALA A  42
 EDO  A 336 (-3.9A)
None
None
SO4  A 349 (-3.8A)
 1.00A 4eyzA-3hjzA:
undetectable		 4eyzA-3hjzA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8g GTPASE DER

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		4 VAL X 129
ILE X 140
SER X 134
ALA X 103
 None
 0.99A 4eyzA-3j8gX:
undetectable		 4eyzA-3j8gX:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw0 CYSTEINE PEPTIDASE

(Bacillus cereus) 		PF05708
(Peptidase_C92) 		4 PHE A 157
VAL A 158
HIS A  49
SER A  65
 None
None
LYS  A 201 (-3.9A)
None
 0.35A 4eyzA-3kw0A:
1.2		 4eyzA-3kw0A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lda DNA REPAIR PROTEIN
RAD51

(Saccharomyces
cerevisiae) 		PF08423
(Rad51)
PF14520
(HHH_5) 		4 VAL A  96
HIS A 105
ILE A  83
ALA A 266
 None
 0.85A 4eyzA-3ldaA:
undetectable		 4eyzA-3ldaA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		4 VAL A  67
ILE A  49
SER A  76
ALA A  54
 None
 0.96A 4eyzA-3mc2A:
undetectable		 4eyzA-3mc2A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mt1 PUTATIVE
CARBOXYNORSPERMIDINE
DECARBOXYLASE
PROTEIN

(Sinorhizobium
meliloti) 		PF00278
(Orn_DAP_Arg_deC) 		4 TYR A  77
VAL A 194
HIS A 162
ILE A 161
 None
 0.98A 4eyzA-3mt1A:
undetectable		 4eyzA-3mt1A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwa ENVELOPE
GLYCOPROTEIN B

(Human
alphaherpesvirus
1) 		no annotation 4 PHE B 508
ILE B 391
SER B 387
ALA B 147
 None
 1.02A 4eyzA-3nwaB:
undetectable		 4eyzA-3nwaB:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tnl SHIKIMATE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF08501
(Shikimate_dh_N) 		4 TYR A  45
ASN A  71
VAL A 101
ILE A 275
 None
SKM  A 293 (-3.4A)
None
None
 0.93A 4eyzA-3tnlA:
undetectable		 4eyzA-3tnlA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE

(Pseudomonas sp.
VM15C) 		no annotation 4 ASN A 279
PHE A 280
HIS A 289
ALA A 291
 None
 1.01A 4eyzA-3wweA:
undetectable		 4eyzA-3wweA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		4 ASN A   6
VAL A  90
HIS A  22
ILE A  19
 None
 1.00A 4eyzA-4azvA:
undetectable		 4eyzA-4azvA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azw WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		4 ASN A   6
VAL A  90
HIS A  22
ILE A  19
 None
 1.00A 4eyzA-4azwA:
undetectable		 4eyzA-4azwA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg5 BBA65

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		4 ASN A 199
VAL A 107
HIS A 117
ILE A 120
 None
 1.00A 4eyzA-4bg5A:
undetectable		 4eyzA-4bg5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpz ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		4 VAL A 227
ILE A 241
SER A 317
ALA A 285
 None
 0.97A 4eyzA-4bpzA:
undetectable		 4eyzA-4bpzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA

(Drosophila
melanogaster;
Eptatretus
burgeri) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 TYR R  52
VAL R  75
ILE R  96
ALA R  33
 None
 0.99A 4eyzA-4bv4R:
undetectable		 4eyzA-4bv4R:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzj PROTEIN TRANSPORT
PROTEIN SEC13

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 VAL B  97
ILE B 140
SER B 120
ALA B 143
 None
 1.00A 4eyzA-4bzjB:
undetectable		 4eyzA-4bzjB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Staphylococcus
epidermidis) 		PF00288
(GHMP_kinases_N) 		4 ASN A  12
VAL A 323
ILE A 146
SER A 109
 None
 1.02A 4eyzA-4dpyA:
undetectable		 4eyzA-4dpyA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dr9 PEPTIDE DEFORMYLASE

(Synechococcus
elongatus) 		PF01327
(Pep_deformylase) 		4 PHE A 161
VAL A 162
HIS A 155
ALA A  63
 None
None
ZN  A 201 ( 3.3A)
None
 1.02A 4eyzA-4dr9A:
undetectable		 4eyzA-4dr9A:
20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eyz CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES

(Ruminococcus
flavefaciens) 		no annotation 8 TYR A  71
ASN A 108
PHE A 112
VAL A 113
HIS A 215
ILE A 216
SER A 231
ALA A 253
 CCS  A 109 ( 4.6A)
CCS  A 109 ( 2.6A)
None
CCS  A 109 ( 4.1A)
CCS  A 109 ( 3.6A)
CCS  A 109 ( 4.4A)
CCS  A 109 ( 4.5A)
CCS  A 109 ( 3.6A)
 0.02A 4eyzA-4eyzA:
49.5		 4eyzA-4eyzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f02 POLYADENYLATE-BINDIN
G PROTEIN 1

(Homo sapiens) 		PF00076
(RRM_1) 		4 ASN A 105
PHE A 169
VAL A 170
ILE A 103
 A  B   2 (-3.8A)
A  B   3 ( 4.7A)
None
None
 1.01A 4eyzA-4f02A:
undetectable		 4eyzA-4f02A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0a PROTEIN WNT-8

(Xenopus laevis) 		PF00110
(wnt) 		4 VAL B 245
ILE B 251
SER B 248
ALA B  91
 None
 0.89A 4eyzA-4f0aB:
undetectable		 4eyzA-4f0aB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fvs PUTATIVE LIPOPROTEIN

(Parabacteroides
distasonis) 		no annotation 4 TYR A  70
ASN A  81
VAL A 107
ILE A 146
 None
 0.95A 4eyzA-4fvsA:
undetectable		 4eyzA-4fvsA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		4 PHE A  89
VAL A  83
ILE A 126
ALA A 121
 None
 0.89A 4eyzA-4fwtA:
undetectable		 4eyzA-4fwtA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7e UREASE

(Cajanus cajan) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		4 ASN B 343
VAL B 391
ILE B 321
ALA B 196
 None
 0.93A 4eyzA-4g7eB:
undetectable		 4eyzA-4g7eB:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt7 IG EPSILON CHAIN C
REGION

(Homo sapiens) 		PF07654
(C1-set) 		4 PHE A 503
HIS A 528
ILE A 474
ALA A 531
 None
 0.89A 4eyzA-4gt7A:
undetectable		 4eyzA-4gt7A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gud IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISH

(Vibrio cholerae) 		PF00117
(GATase) 		4 ASN A  14
ILE A   7
SER A  16
ALA A  21
 None
 0.99A 4eyzA-4gudA:
undetectable		 4eyzA-4gudA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		4 TYR A 200
ASN A 202
ILE A 145
ALA A 155
 None
 0.91A 4eyzA-4jz6A:
undetectable		 4eyzA-4jz6A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans) 		PF00343
(Phosphorylase) 		5 ASN A 410
PHE A 408
VAL A 381
HIS A 388
ALA A 601
 None
 1.30A 4eyzA-4l22A:
undetectable		 4eyzA-4l22A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le7 PYOCIN L1

(Pseudomonas
aeruginosa) 		PF01453
(B_lectin) 		4 ASN A  93
PHE A 100
ILE A  17
ALA A   6
 None
None
None
EDO  A 301 ( 4.1A)
 1.02A 4eyzA-4le7A:
undetectable		 4eyzA-4le7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvo SUBTILISIN-LIKE
SERINE PROTEASE

(Plasmodium
falciparum) 		PF00082
(Peptidase_S8) 		4 VAL A 449
ILE A 657
SER A 617
ALA A 664
 None
 0.88A 4eyzA-4lvoA:
undetectable		 4eyzA-4lvoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxr PROTEIN TOLL

(Drosophila
melanogaster) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 TYR A  52
VAL A  75
ILE A  96
ALA A  33
 None
 0.96A 4eyzA-4lxrA:
undetectable		 4eyzA-4lxrA:
14.69