SIMILAR PATTERNS OF AMINO ACIDS FOR 4EYS_A_ACTA402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		4 ASP A 648
SER A 722
ASP A 723
GLU A 777
 None
 1.14A 4eysA-1c7tA:
undetectable		 4eysA-1c7tA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dp2 RHODANESE

(Bos taurus) 		PF00581
(Rhodanese) 		4 ASP A  99
ASP A 102
ARG A  41
GLU A  46
 None
 1.20A 4eysA-1dp2A:
undetectable		 4eysA-1dp2A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
SMALL SUBUNIT

(Desulfovibrio
desulfuricans) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 SER A 185
ASP A 173
ARG A 177
GLU A 253
 None
 1.19A 4eysA-1e3dA:
2.6		 4eysA-1e3dA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT

(Mus musculus) 		PF03129
(HGTP_anticodon) 		4 SER A 311
ASP A 254
ARG A 258
GLU A 284
 None
 1.04A 4eysA-1g5iA:
2.4		 4eysA-1g5iA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF00490
(ALAD) 		4 ASP A  66
SER A  64
ARG A  51
GLU A  71
 None
 1.26A 4eysA-1gzgA:
undetectable		 4eysA-1gzgA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp2 ARGININOSUCCINATE
SYNTHETASE

(Escherichia
coli) 		PF00764
(Arginosuc_synth) 		4 ASP A 127
SER A 129
ASP A 135
ARG A 106
 None
ATP  A 459 (-4.7A)
ATP  A 459 (-3.5A)
ATP  A 459 ( 4.0A)
 1.03A 4eysA-1kp2A:
undetectable		 4eysA-1kp2A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ns5 HYPOTHETICAL PROTEIN
YBEA

(Escherichia
coli) 		PF02590
(SPOUT_MTase) 		4 SER A  99
ASP A  97
ASP A  94
ARG A  96
 None
 1.18A 4eysA-1ns5A:
2.3		 4eysA-1ns5A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otw COENZYME PQQ
SYNTHESIS PROTEIN C

(Klebsiella
pneumoniae) 		PF03070
(TENA_THI-4) 		4 ASP A  83
ASP A  61
ARG A  80
GLU A 147
 None
PQQ  A 500 ( 4.5A)
PQQ  A 500 ( 4.9A)
PQQ  A 500 ( 4.1A)
 1.09A 4eysA-1otwA:
undetectable		 4eysA-1otwA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ASP A 259
SER A 301
ARG A 740
GLU A 306
 None
 1.00A 4eysA-1qf7A:
3.6		 4eysA-1qf7A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT

(Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU) 		4 SER A 139
ASP A 358
ARG A 257
GLU A 168
 None
 1.11A 4eysA-1uc4A:
undetectable		 4eysA-1uc4A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrc S-ADENOSYLMETHIONINE
SYNTHETASE

(Escherichia
coli) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 SER A  23
ASP A  20
SER A 263
GLU A  42
 None
None
None
K  A 413 (-2.9A)
 1.02A 4eysA-1xrcA:
undetectable		 4eysA-1xrcA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y82 HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		PF01850
(PIN) 		4 SER A  11
ASP A  10
ASP A 116
ARG A 119
 UNX  A 333 ( 3.0A)
UNX  A 333 ( 3.5A)
None
None
 1.25A 4eysA-1y82A:
2.5		 4eysA-1y82A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aey FRUCTAN
1-EXOHYDROLASE IIA

(Cichorium
intybus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 SER A  57
ASP A 281
ARG A 286
GLU A 333
 None
 0.98A 4eysA-2aeyA:
undetectable		 4eysA-2aeyA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkl PROLYL ENDOPEPTIDASE

(Myxococcus
xanthus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 SER A 424
ASP A 507
ARG A 546
GLU A 514
 None
 1.22A 4eysA-2bklA:
undetectable		 4eysA-2bklA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch0 INNER NUCLEAR
MEMBRANE PROTEIN
MAN1

(Homo sapiens) 		PF09402
(MSC) 		4 ASP A  26
SER A  30
ARG A  29
GLU A  78
 None
 1.21A 4eysA-2ch0A:
undetectable		 4eysA-2ch0A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cow KINESIN-LIKE PROTEIN
KIF13B

(Homo sapiens) 		PF01302
(CAP_GLY) 		4 SER A  12
ASP A  13
SER A  14
GLU A  16
 None
 1.22A 4eysA-2cowA:
undetectable		 4eysA-2cowA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT

(Bacillus sp.
RAPc8;
Bacillus sp.
RAPc8) 		PF02979
(NHase_alpha)
PF02211
(NHase_beta) 		4 ASP B 218
SER A 170
ARG A 174
GLU A 172
 None
None
CSO  A 121 ( 3.3A)
None
 1.13A 4eysA-2dppB:
undetectable		 4eysA-2dppB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9f ARGININOSUCCINATE
LYASE

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		4 ASP A  35
ASP A  84
ARG A 110
GLU A  90
 None
 1.00A 4eysA-2e9fA:
undetectable		 4eysA-2e9fA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 SER A 339
ASP A 340
ARG A 126
GLU A 460
 None
 1.07A 4eysA-2gv9A:
undetectable		 4eysA-2gv9A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF13432
(TPR_16) 		4 SER A 535
ASP A 538
SER A 541
ARG A 540
 None
 1.14A 4eysA-2gw1A:
undetectable		 4eysA-2gw1A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlx XYLULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 SER A  34
SER A  41
ASP A  98
ARG A 100
 None
 1.25A 4eysA-2nlxA:
1.1		 4eysA-2nlxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 ASP A 517
SER A 267
ARG A 526
GLU A 417
 None
None
PRX  A 998 (-3.9A)
PRX  A 998 ( 4.8A)
 1.21A 4eysA-2p2mA:
2.6		 4eysA-2p2mA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 SER A 998
ASP A 999
ARG A 974
GLU A 980
 None
 0.95A 4eysA-2qf7A:
2.6		 4eysA-2qf7A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		4 SER A 548
ASP A 544
ARG A 791
GLU A 742
 None
 1.22A 4eysA-2w92A:
undetectable		 4eysA-2w92A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wuq BETA-LACTAMASE
REGULATORY PROTEIN
BLAB

(Streptomyces
cacaoi) 		PF13354
(Beta-lactamase2) 		5 SER A 109
ASP A 110
SER A 114
ASP A 115
ARG A 145
 None
 1.44A 4eysA-2wuqA:
undetectable		 4eysA-2wuqA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xiv HYPOTHETICAL
INVASION PROTEIN

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		4 ASP A 447
ASP A 268
ARG A 458
GLU A 444
 None
 1.26A 4eysA-2xivA:
undetectable		 4eysA-2xivA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT FACTOR B

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin)
PF00092
(VWA) 		4 SER F 185
ASP F 422
ARG F 683
GLU F 596
 None
 1.08A 4eysA-2xwbF:
3.2		 4eysA-2xwbF:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2k TRNA(ILE)-LYSIDINE
SYNTHASE

(Geobacillus
kaustophilus) 		PF01171
(ATP_bind_3)
PF09179
(TilS)
PF11734
(TilS_C) 		4 SER A  31
ASP A  30
ASP A 189
GLU A  66
 None
 1.25A 4eysA-3a2kA:
2.1		 4eysA-3a2kA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		no annotation 4 SER C 329
ASP C 328
SER C 331
ASP C 113
 None
 1.17A 4eysA-3amjC:
undetectable		 4eysA-3amjC:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwk CYSTEINE PROTEASE
FALCIPAIN-3

(Plasmodium
falciparum) 		PF00112
(Peptidase_C1) 		4 ASP A 112
SER A 109
ARG A 131
GLU A  78
 None
 1.15A 4eysA-3bwkA:
undetectable		 4eysA-3bwkA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c10 HISTONE DEACETYLASE
7A

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 SER A 644
ASP A 647
ARG A 570
GLU A 576
 None
 1.11A 4eysA-3c10A:
undetectable		 4eysA-3c10A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 SER A  76
ASP A  75
ASP A  73
GLU A  27
 None
 1.20A 4eysA-3cinA:
undetectable		 4eysA-3cinA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq0 PUTATIVE
TRANSALDOLASE
YGR043C

(Saccharomyces
cerevisiae) 		PF00923
(TAL_FSA) 		4 SER A 189
ASP A  43
ARG A 104
GLU A 233
 None
 1.09A 4eysA-3cq0A:
undetectable		 4eysA-3cq0A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw6 CELLULASE

(uncultured
bacterium) 		PF12891
(Glyco_hydro_44) 		4 SER A 354
ASP A 357
ASP A 465
GLU A 363
 None
 1.00A 4eysA-3fw6A:
2.1		 4eysA-3fw6A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gv5 DNA POLYMERASE IOTA

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		4 SER B 154
SER B 177
ARG B 139
GLU B 182
 None
 1.13A 4eysA-3gv5B:
undetectable		 4eysA-3gv5B:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 SER A 182
ASP A 181
SER A 186
GLU A 155
 None
 1.20A 4eysA-3h9uA:
2.7		 4eysA-3h9uA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kf8 PROTEIN STN1
PROTEIN TEN1

(Candida
tropicalis;
Candida
tropicalis) 		PF10451
(Stn1)
PF12658
(Ten1) 		4 SER A 114
ASP B  83
ARG B  27
GLU A 189
 None
 1.24A 4eysA-3kf8A:
undetectable		 4eysA-3kf8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		4 ASP A 344
ASP A 349
ARG A 345
GLU A 230
 None
 1.15A 4eysA-3kl9A:
undetectable		 4eysA-3kl9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kt4 PKHD-TYPE
HYDROXYLASE TPA1

(Saccharomyces
cerevisiae) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		4 ASP A 636
SER A 634
ASP A 528
GLU A 301
 None
 1.24A 4eysA-3kt4A:
undetectable		 4eysA-3kt4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA

(Allochromatium
vinosum) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 SER A 185
ASP A 173
ARG A 177
GLU A 254
 None
 1.18A 4eysA-3myrA:
2.6		 4eysA-3myrA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 SER A 219
ASP A 218
SER A 223
GLU A 192
 None
None
None
ADN  A 500 (-3.6A)
 1.18A 4eysA-3n58A:
2.9		 4eysA-3n58A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ns4 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 53

(Saccharomyces
cerevisiae) 		PF16854
(VPS53_C) 		4 SER A 700
ASP A 699
ARG A 743
GLU A 759
 None
 1.17A 4eysA-3ns4A:
undetectable		 4eysA-3ns4A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz3 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		no annotation 4 SER A  90
ASP A  89
SER A  88
GLU A  85
 SO4  A 401 (-4.8A)
None
None
None
 1.14A 4eysA-3nz3A:
undetectable		 4eysA-3nz3A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odh OKRAI ENDONUCLEASE

(Oceanobacter
kriegii) 		PF02923
(BamHI) 		4 SER A 108
SER A 106
ARG A 143
GLU A 149
 None
 1.18A 4eysA-3odhA:
undetectable		 4eysA-3odhA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 SER A 232
ASP A 231
SER A 236
GLU A 205
 None
 1.21A 4eysA-3oneA:
2.7		 4eysA-3oneA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qh4 ESTERASE LIPW

(Mycobacterium
marinum) 		PF07859
(Abhydrolase_3) 		4 ASP A 100
SER A 288
ARG A  41
GLU A  48
 None
 0.84A 4eysA-3qh4A:
undetectable		 4eysA-3qh4A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re2 PREDICTED PROTEIN

(Nematostella
vectensis) 		PF05053
(Menin) 		4 SER A 228
ASP A 227
SER A 232
GLU A  42
 None
 0.99A 4eysA-3re2A:
undetectable		 4eysA-3re2A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t32 AMINOTRANSFERASE,
CLASS I/II

(Bacillus
anthracis) 		PF00155
(Aminotran_1_2) 		4 ASP A 332
SER A 330
ARG A 334
GLU A 350
 None
 1.00A 4eysA-3t32A:
undetectable		 4eysA-3t32A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tg3 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
16

(Homo sapiens) 		PF00581
(Rhodanese) 		4 ASP A  89
SER A  31
ASP A  30
GLU A  36
 None
 1.25A 4eysA-3tg3A:
undetectable		 4eysA-3tg3A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 SER A  67
ASP A 417
ARG A 415
GLU A 348
 None
 0.96A 4eysA-3u9sA:
3.1		 4eysA-3u9sA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 SER A1073
ASP A1069
ARG A1046
GLU A 570
 None
 1.09A 4eysA-3ummA:
4.2		 4eysA-3ummA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up6 HYPOTHETICAL PROTEIN
BACOVA_04078

(Bacteroides
ovatus) 		no annotation 4 SER A 113
SER A 116
ASP A 119
GLU A 110
 None
 1.26A 4eysA-3up6A:
undetectable		 4eysA-3up6A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w53 BETA-GLUCOSIDASE

(Micrococcus
antarcticus) 		PF00232
(Glyco_hydro_1) 		4 ASP A 110
SER A 106
ASP A 103
ARG A 107
 None
 1.26A 4eysA-3w53A:
2.6		 4eysA-3w53A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 SER A 104
ASP A 100
ARG A 200
GLU A 271
 GOL  A 601 (-3.2A)
None
BGC  A 605 (-3.0A)
BGC  A 605 (-3.3A)
 1.24A 4eysA-3wy2A:
undetectable		 4eysA-3wy2A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		4 SER A 236
ASP A 241
ARG A 485
GLU A 475
 None
 1.21A 4eysA-3x1lA:
undetectable		 4eysA-3x1lA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF02156
(Glyco_hydro_26)
PF16990
(CBM_35) 		4 SER A 198
ASP A 275
ARG A 274
GLU A 203
 None
 1.25A 4eysA-3zm8A:
undetectable		 4eysA-3zm8A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqt LAMININ SUBUNIT
GAMMA-1

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		4 SER A 177
ASP A 205
SER A 208
ASP A 209
 None
 1.14A 4eysA-4aqtA:
undetectable		 4eysA-4aqtA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsq PEROXIREDOXIN TYPE-2

(Saccharomyces
cerevisiae) 		PF08534
(Redoxin) 		4 SER A  30
ASP A  25
SER A  28
ASP A  27
 None
 1.26A 4eysA-4dsqA:
undetectable		 4eysA-4dsqA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE

(Mycobacterium
avium) 		PF04909
(Amidohydro_2) 		4 SER A 206
ASP A 209
ASP A 213
ARG A 282
 None
 1.14A 4eysA-4dziA:
undetectable		 4eysA-4dziA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		4 SER A 254
ASP A 253
ARG A 244
GLU A 260
 None
 1.25A 4eysA-4e0tA:
undetectable		 4eysA-4e0tA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei6 VALPHA1 XV19 TYPE II
NATURAL KILLER T
CELL RECEPTOR (MOUSE
VARIABLE DOMAIN,
HUMAN CONSTANT
DOMAIN)

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		4 SER A  84
ASP A  83
SER A  82
GLU A  15
 None
 1.15A 4eysA-4ei6A:
undetectable		 4eysA-4ei6A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eme M18 ASPARTYL
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF02127
(Peptidase_M18) 		4 SER A  22
ASP A 378
ARG A  63
GLU A 300
 None
 0.90A 4eysA-4emeA:
undetectable		 4eysA-4emeA:
20.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eys MCCC FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF02016
(Peptidase_S66) 		6 SER A 109
ASP A 110
SER A 212
ASP A 215
ARG A 221
GLU A 253
 AMP  A 401 (-2.9A)
ACT  A 402 (-4.9A)
ACT  A 402 (-3.2A)
ACT  A 402 ( 4.5A)
ACT  A 402 (-3.6A)
ACT  A 402 ( 3.8A)
 0.55A 4eysA-4eysA:
65.5		 4eysA-4eysA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 ASP A 314
SER A 311
ARG A 376
GLU A 415
 None
 1.13A 4eysA-4fddA:
undetectable		 4eysA-4fddA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i66 UNCHARACTERIZED
PROTEIN HOCH_4089

(Haliangium
ochraceum) 		PF13709
(DUF4159) 		4 SER A 173
ASP A 129
ARG A 133
GLU A 177
 None
 1.05A 4eysA-4i66A:
3.0		 4eysA-4i66A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkw BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1

(Homo sapiens) 		PF07686
(V-set) 		4 SER A  94
ASP A  93
SER A  92
GLU A 118
 None
 1.07A 4eysA-4jkwA:
undetectable		 4eysA-4jkwA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN

(Neisseria
meningitidis) 		PF00884
(Sulfatase) 		4 SER A 325
ASP A 324
ARG A 390
GLU A 352
 None
TPO  A 280 ( 3.9A)
NA  A 606 (-4.1A)
NA  A 606 (-3.2A)
 1.22A 4eysA-4kavA:
undetectable		 4eysA-4kavA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nar PUTATIVE URONATE
ISOMERASE

(Thermotoga
maritima) 		PF09861
(DUF2088) 		4 ASP A  38
ASP A 280
ARG A  74
GLU A  80
 None
 0.89A 4eysA-4narA:
undetectable		 4eysA-4narA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4g PEPTIDOGLYCAN
ENDOPEPTIDASE RIPA

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		4 ASP X1185
ASP X1006
ARG X1196
GLU X1182
 None
 1.24A 4eysA-4q4gX:
undetectable		 4eysA-4q4gX:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 4 SER A 384
ASP A 383
ASP A 275
GLU A 425
 None
CL  A 910 (-4.9A)
CL  A 911 ( 4.5A)
None
 0.87A 4eysA-4qnlA:
2.6		 4eysA-4qnlA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1p ATP-DEPENDENT RNA
LIGASE

(Methanothermobacter
thermautotrophicus) 		PF09414
(RNA_ligase) 		4 ASP A 237
SER A 239
ARG A  91
GLU A 189
 None
 1.22A 4eysA-5d1pA:
undetectable		 4eysA-5d1pA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7g IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650

(Bacteroides
ovatus) 		no annotation 4 SER A 426
SER A 440
ARG A 485
GLU A 394
 None
 1.21A 4eysA-5e7gA:
undetectable		 4eysA-5e7gA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7h IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650

(Bacteroides
ovatus) 		PF01833
(TIG) 		4 SER A 426
SER A 440
ARG A 485
GLU A 394
 None
 1.03A 4eysA-5e7hA:
undetectable		 4eysA-5e7hA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eft P9-1

(Southern rice
black-streaked
dwarf virus) 		PF06043
(Reo_P9) 		4 SER B 168
ASP B 120
ARG B 175
GLU B 189
 None
 1.25A 4eysA-5eftB:
undetectable		 4eysA-5eftB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3y UNCONVENTIONAL
MYOSIN-VIIB

(Mus musculus) 		PF00784
(MyTH4) 		4 SER A1194
ASP A1193
ARG A1151
GLU A1200
 None
 1.01A 4eysA-5f3yA:
undetectable		 4eysA-5f3yA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsy MACRODOMAIN

(Trypanosoma
brucei) 		PF01661
(Macro) 		4 ASP A 115
SER A 203
ASP A 241
ARG A 202
 None
 1.23A 4eysA-5fsyA:
undetectable		 4eysA-5fsyA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fvn OMPC PORIN

(Enterobacter
cloacae) 		PF00267
(Porin_1) 		4 SER A 155
SER A 202
ASP A 205
GLU A 159
 None
 0.87A 4eysA-5fvnA:
undetectable		 4eysA-5fvnA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 SER A 481
SER A 435
ASP A 436
GLU A 484
 MG  A 715 (-3.1A)
MG  A 715 (-3.8A)
None
None
 1.20A 4eysA-5ixqA:
undetectable		 4eysA-5ixqA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		4 ASP A 219
SER A 125
ASP A 126
GLU A 123
 None
 0.92A 4eysA-5j44A:
undetectable		 4eysA-5j44A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjd COLLAGEN TYPE IV
ALPHA-3-BINDING
PROTEIN

(Homo sapiens) 		PF01852
(START) 		4 SER B 511
ASP B 510
ARG B 366
GLU B 456
 None
 0.85A 4eysA-5jjdB:
undetectable		 4eysA-5jjdB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvk UNCHARACTERIZED
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 4 ASP A 496
ASP A  73
ARG A  70
GLU A  93
 None
 1.08A 4eysA-5jvkA:
3.6		 4eysA-5jvkA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF02012
(BNR) 		4 SER A  77
ASP A  78
ASP A  83
GLU A  32
 None
 1.06A 4eysA-5jwzA:
undetectable		 4eysA-5jwzA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxf FLOWERING TIME
CONTROL PROTEIN FPA

(Arabidopsis
thaliana) 		PF07744
(SPOC) 		4 SER A 517
ASP A 520
SER A 539
ASP A 540
 None
 1.21A 4eysA-5kxfA:
undetectable		 4eysA-5kxfA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB

(Klebsiella
pneumoniae) 		PF00005
(ABC_tran)
PF12399
(BCA_ABC_TP_C) 		4 SER A 133
ASP A 132
SER A  94
ASP A  97
 None
 1.26A 4eysA-5l75A:
undetectable		 4eysA-5l75A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT

(Ovis aries) 		PF00420
(Oxidored_q2) 		4 ASP k  28
ASP k 131
ARG k 104
GLU k 125
 None
 1.23A 4eysA-5lnkk:
undetectable		 4eysA-5lnkk:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, 42 KDA
SUBUNIT

(Ovis aries) 		PF00420
(Oxidored_q2) 		4 SER k 130
ASP k 131
ARG k 104
GLU k 125
 None
 1.15A 4eysA-5lnkk:
undetectable		 4eysA-5lnkk:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Streptomyces
venezuelae) 		PF00982
(Glyco_transf_20) 		4 SER A  44
ASP A  43
SER A   3
ASP A 133
 None
 1.26A 4eysA-5lqdA:
undetectable		 4eysA-5lqdA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvh BACCELL_00856

(Bacteroides
cellulosilyticus) 		PF15892
(BNR_4) 		4 SER A 274
ASP A 339
ARG A 395
GLU A 204
 None
 0.95A 4eysA-5mvhA:
undetectable		 4eysA-5mvhA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 SER A 234
ASP A 235
SER A 207
ASP A 205
 None
 1.20A 4eysA-5necA:
undetectable		 4eysA-5necA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE

(metagenome) 		no annotation 4 SER A  50
ASP A  51
ARG A  52
GLU A 292
 None
 1.24A 4eysA-5nfqA:
undetectable		 4eysA-5nfqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ook PHYCOCYANIN, ALPHA
SUBUNIT

(Acaryochloris
marina) 		no annotation 4 SER A  10
ASP A  13
ARG A  17
GLU A  23
 None
 1.26A 4eysA-5ookA:
undetectable		 4eysA-5ookA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 SER A 238
ASP A 237
SER A 242
GLU A 211
 None
None
None
SAH  A 502 (-3.8A)
 1.20A 4eysA-5utuA:
2.4		 4eysA-5utuA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE

(Naegleria
fowleri) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 SER A 224
ASP A 223
SER A 228
GLU A 197
 None
None
None
ADN  A 502 (-3.5A)
 1.24A 4eysA-5v96A:
2.7		 4eysA-5v96A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCE

(Pseudomonas
aeruginosa) 		PF06833
(MdcE) 		4 ASP A  82
ASP A  34
ARG A  43
GLU A  77
 None
 1.06A 4eysA-5vipA:
undetectable		 4eysA-5vipA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D

(Methylobacterium
extorquens) 		no annotation 4 ASP D  94
ASP D  72
ARG D  91
GLU D 158
 None
 1.04A 4eysA-5vrdD:
undetectable		 4eysA-5vrdD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii) 		no annotation 4 SER A 348
ASP A 347
ARG A 199
GLU A 331
 None
 1.00A 4eysA-5z0yA:
undetectable		 4eysA-5z0yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae) 		no annotation 4 ASP A 259
SER A 170
ARG A 171
GLU A 168
 None
 1.14A 4eysA-6brdA:
undetectable		 4eysA-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvg PROTEIN-N(PI)-PHOSPH
OHISTIDINE-SUGAR
PHOSPHOTRANSFERASE
(ENZYME II OF THE
PHOSPHOTRANSFERASE
SYSTEM) (PTS SYSTEM
GLUCOSE-SPECIFIC
IIBC COMPONENT)

(Bacillus cereus) 		no annotation 4 SER A 218
ASP A 217
ASP A 384
ARG A 305
 None
 1.04A 4eysA-6bvgA:
undetectable		 4eysA-6bvgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fea NITROGENASE PROTEIN
ALPHA CHAIN
VANADIUM
NITROGENASE, DELTA
SUBUNIT, VNFG

(Azotobacter
vinelandii;
Azotobacter
vinelandii) 		no annotation
no annotation 		4 ASP C  97
ASP A  27
ARG A  29
GLU C  14
 None
None
None
MG  C 201 ( 4.8A)
 1.15A 4eysA-6feaC:
undetectable		 4eysA-6feaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 4 SER A 186
ASP A 185
SER A 190
GLU A 159
 None
None
None
ADN  A 501 (-3.9A)
 1.25A 4eysA-6gbnA:
3.1		 4eysA-6gbnA:
undetectable