SIMILAR PATTERNS OF AMINO ACIDS FOR 4EYR_B_RITB301_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akm ORNITHINE
TRANSCARBAMYLASE

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ARG A 106
ALA A  65
ASP A  68
THR A 135
 None
 0.76A 4eyrB-1akmA:
undetectable		 4eyrB-1akmA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5l INTERFERON TAU

(Komagataella
pastoris) 		PF00143
(Interferon) 		4 ARG A  12
ASN A  14
GLY A  88
THR A 156
 SO4  A 201 (-2.8A)
None
None
None
 0.55A 4eyrB-1b5lA:
undetectable		 4eyrB-1b5lA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkg MOLECULAR CHAPERONE
DNAK

(Escherichia
coli) 		PF00012
(HSP70) 		4 GLY D 328
ALA D 327
ASP D 326
THR D 189
 None
 0.87A 4eyrB-1dkgD:
0.0		 4eyrB-1dkgD:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 GLY A 106
ALA A 107
ASP A 108
ASP A 138
 None
 0.54A 4eyrB-1e43A:
undetectable		 4eyrB-1e43A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 GLY A 268
ALA A 269
ASP A 247
THR A 262
 None
 0.88A 4eyrB-1edzA:
0.0		 4eyrB-1edzA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw8 PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		5 ARG A 110
ASN A  89
ALA A  91
ASP A 367
PRO A 335
 None
None
None
GOL  A 973 (-3.6A)
None
 1.47A 4eyrB-1fw8A:
undetectable		 4eyrB-1fw8A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 ASN A 176
GLY A 624
ALA A 625
THR A 281
 None
 0.86A 4eyrB-1g0dA:
0.0		 4eyrB-1g0dA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h14 ENDO-1,4-BETA-XYLANA
SE

(Pseudoalteromonas
haloplanktis) 		PF01270
(Glyco_hydro_8) 		5 ASN A  44
GLY A  42
ASP A  38
PRO A 374
THR A 375
 None
 1.33A 4eyrB-1h14A:
0.0		 4eyrB-1h14A:
13.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 ARG A   8
GLY A  27
ALA A  28
ASP A  29
ASP A  30
PRO A  81
 A79  A 800 (-3.4A)
A79  A 800 (-3.0A)
A79  A 800 (-3.1A)
A79  A 800 (-2.8A)
A79  A 800 ( 4.9A)
A79  A 800 ( 3.9A)
 0.89A 4eyrB-1hvcA:
12.5		 4eyrB-1hvcA:
43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 ARG A   8
GLY A  27
ALA A  28
ASP A  29
ASP A  30
PRO A  81
 A79  A 800 (-3.6A)
A79  A 800 (-3.0A)
A79  A 800 (-3.2A)
A79  A 800 (-2.7A)
A79  A 800 ( 4.7A)
A79  A 800 ( 3.4A)
 0.59A 4eyrB-1hvcA:
12.5		 4eyrB-1hvcA:
43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ARG A  87
GLY A  27
ALA A  28
ASP A  29
ASP A  30
 None
A79  A 800 (-3.0A)
A79  A 800 (-3.1A)
A79  A 800 (-2.8A)
A79  A 800 ( 4.9A)
 1.13A 4eyrB-1hvcA:
12.5		 4eyrB-1hvcA:
43.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 GLY A 247
ALA A 246
ASP A 242
PRO A 344
THR A 343
 None
 1.38A 4eyrB-1iq0A:
undetectable		 4eyrB-1iq0A:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js1 TRANSCARBAMYLASE

(Bacteroides
fragilis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 GLY X 229
ALA X 230
ASP X 231
THR X 202
 None
 0.47A 4eyrB-1js1X:
undetectable		 4eyrB-1js1X:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1d D-HYDANTOINASE

(Geobacillus
stearothermophilus) 		PF01979
(Amidohydro_1) 		4 GLY A 388
ASP A 390
ASP A 392
THR A  12
 None
 0.79A 4eyrB-1k1dA:
undetectable		 4eyrB-1k1dA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ll2 GLYCOGENIN-1

(Oryctolagus
cuniculus) 		PF01501
(Glyco_transf_8) 		5 GLY A  18
ALA A 103
ASP A 104
ASP A 102
THR A  39
 None
UPG  A 334 (-3.3A)
MN  A 333 ( 2.1A)
MN  A 333 ( 3.1A)
None
 1.28A 4eyrB-1ll2A:
undetectable		 4eyrB-1ll2A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4x PBCV-1 VIRUS CAPSID

(Paramecium
bursaria
Chlorella virus
1) 		PF04451
(Capsid_NCLDV)
PF16903
(Capsid_N) 		4 ASN A 280
GLY A 289
ALA A 288
ASP A 299
 None
 0.88A 4eyrB-1m4xA:
undetectable		 4eyrB-1m4xA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8p CYSTATHIONINE
GAMMA-LYASE

(Saccharomyces
cerevisiae) 		PF01053
(Cys_Met_Meta_PP) 		4 GLY A 193
ALA A 194
ASP A 195
THR A 146
 None
 0.74A 4eyrB-1n8pA:
undetectable		 4eyrB-1n8pA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfg D-HYDANTOINASE

(Ralstonia
pickettii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 GLY A 385
ASP A 387
ASP A 389
THR A  12
 None
 0.69A 4eyrB-1nfgA:
undetectable		 4eyrB-1nfgA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyt SHIKIMATE
5-DEHYDROGENASE

(Escherichia
coli) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ARG A 154
GLY A  83
ALA A  84
PRO A  63
 NAP  A1401 (-4.0A)
None
None
NAP  A1401 ( 4.7A)
 0.81A 4eyrB-1nytA:
undetectable		 4eyrB-1nytA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9b HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN YDIB

(Escherichia
coli) 		PF08501
(Shikimate_dh_N) 		4 ARG A 156
GLY A 134
ALA A 135
ASP A 107
 NAI  A 301 (-3.5A)
NAI  A 301 (-3.1A)
NAI  A 301 (-3.7A)
PO4  A 302 (-3.0A)
 0.76A 4eyrB-1o9bA:
undetectable		 4eyrB-1o9bA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9j ALDEHYDE
DEHYDROGENASE,
CYTOSOLIC 1

(Elephantulus
edwardii) 		PF00171
(Aldedh) 		5 GLY A 229
ALA A 228
ASP A  55
ASP A  58
PRO A 198
 NAD  A1501 (-3.5A)
None
None
None
None
 1.32A 4eyrB-1o9jA:
undetectable		 4eyrB-1o9jA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 GLY A 192
ALA A 193
PRO A 165
THR A 133
 None
None
None
GDP  A1318 ( 4.9A)
 0.73A 4eyrB-1ofuA:
undetectable		 4eyrB-1ofuA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh3 NON-CATALYTIC
PROTEIN 1

(Piromyces equi) 		no annotation 4 ARG A 124
GLY A  47
ALA A  48
ASP A 114
 None
 0.87A 4eyrB-1oh3A:
undetectable		 4eyrB-1oh3A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh9 ACETYLGLUTAMATE
KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		4 GLY A 173
ALA A 174
ASP A 175
PRO A 143
 None
 0.80A 4eyrB-1oh9A:
undetectable		 4eyrB-1oh9A:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q9p HIV-1 PROTEASE

(Homo sapiens) 		PF00077
(RVP) 		4 GLY A  27
ALA A  28
ASP A  29
ASP A  30
 None
 0.34A 4eyrB-1q9pA:
10.2		 4eyrB-1q9pA:
83.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)

(Rattus
norvegicus) 		PF00149
(Metallophos) 		4 ARG A  37
GLY A  43
ALA A  44
ASP A  45
 None
 0.83A 4eyrB-1qfcA:
undetectable		 4eyrB-1qfcA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3f TRNA PSEUDOURIDINE
SYNTHASE B

(Escherichia
coli) 		PF01509
(TruB_N)
PF09157
(TruB-C_2)
PF16198
(TruB_C_2) 		4 ASN A  37
GLY A   8
ASP A  10
PRO A 232
 None
 0.73A 4eyrB-1r3fA:
undetectable		 4eyrB-1r3fA:
16.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		6 ARG A   8
GLY A  27
ALA A  28
ASP A  29
ASP A  30
PRO A  81
 None
 0.59A 4eyrB-1sivA:
17.9		 4eyrB-1sivA:
47.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF06026
(Rib_5-P_isom_A) 		4 ARG A 213
GLY A  87
ALA A  88
ASP A  89
 None
 0.88A 4eyrB-1uj4A:
undetectable		 4eyrB-1uj4A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 218
ALA A 219
ASP A 220
THR A 205
 None
 0.88A 4eyrB-1uufA:
undetectable		 4eyrB-1uufA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb5 TRANSLATION
INITIATION FACTOR
EIF-2B

(Pyrococcus
horikoshii) 		PF01008
(IF-2B) 		4 GLY A 184
ALA A 185
ASP A 186
PRO A 271
 None
 0.85A 4eyrB-1vb5A:
undetectable		 4eyrB-1vb5A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY

(Thermotoga
maritima) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 ALA A 128
ASP A 129
ASP A 181
PRO A 211
 None
 0.81A 4eyrB-1vmaA:
undetectable		 4eyrB-1vmaA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xec DECORIN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 ASN A 238
ALA A 209
ASP A 208
ASP A 232
 None
 0.84A 4eyrB-1xecA:
undetectable		 4eyrB-1xecA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7n L(+)-MANDELATE
DEHYDROGENASE

(Pseudomonas
putida;
Spinacia
oleracea) 		PF01070
(FMN_dh) 		4 GLY A 246
ALA A 247
ASP A 248
THR A 157
 None
 0.87A 4eyrB-2a7nA:
undetectable		 4eyrB-2a7nA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN

(Streptococcus
pneumoniae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ASN A 316
GLY A 317
ALA A 318
ASP A 319
 None
 0.79A 4eyrB-2am2A:
undetectable		 4eyrB-2am2A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bws XAA-PRO
AMINOPEPTIDASE P

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 ARG A 221
GLY A 262
ALA A 261
ASP A 260
 None
None
None
MN  A1442 (-2.0A)
 0.83A 4eyrB-2bwsA:
undetectable		 4eyrB-2bwsA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		5 GLY A 487
ALA A 491
ASP A 493
PRO A 270
THR A 246
 None
 1.28A 4eyrB-2d4eA:
undetectable		 4eyrB-2d4eA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7u ADENYLOSUCCINATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00709
(Adenylsucc_synt) 		5 ARG A  55
GLY A 132
ALA A 134
ASP A 137
PRO A  78
 None
 1.47A 4eyrB-2d7uA:
undetectable		 4eyrB-2d7uA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF05694
(SBP56) 		4 ARG A 346
GLY A 365
ALA A 371
ASP A 372
 None
 0.80A 4eyrB-2eceA:
undetectable		 4eyrB-2eceA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eih ALCOHOL
DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 235
ALA A 236
ASP A 237
THR A 197
 None
 0.64A 4eyrB-2eihA:
undetectable		 4eyrB-2eihA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 ASN A 181
GLY A 184
ALA A 185
ASP A 186
 None
GOL  A2004 ( 4.4A)
None
None
 0.82A 4eyrB-2elcA:
undetectable		 4eyrB-2elcA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eng ENDOGLUCANASE V

(Humicola
insolens) 		PF02015
(Glyco_hydro_45) 		4 GLY A 128
ASP A 121
PRO A  61
THR A  60
 None
 0.87A 4eyrB-2engA:
undetectable		 4eyrB-2engA:
16.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE

(Equine
infectious
anemia virus) 		PF00077
(RVP) 		4 ARG A   8
GLY A  27
ALA A  28
ASP A  29
 LP1  A 201 (-3.5A)
LP1  A 201 (-3.8A)
LP1  A 201 (-3.5A)
LP1  A 201 (-3.6A)
 0.39A 4eyrB-2fmbA:
13.9		 4eyrB-2fmbA:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE

(Equine
infectious
anemia virus) 		PF00077
(RVP) 		4 GLY A  27
ALA A  28
ASP A  29
PRO A  86
 LP1  A 201 (-3.8A)
LP1  A 201 (-3.5A)
LP1  A 201 (-3.6A)
LP1  A 201 (-3.9A)
 0.41A 4eyrB-2fmbA:
13.9		 4eyrB-2fmbA:
30.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fq0 ACYL CARRIER PROTEIN

(Plasmodium
falciparum) 		PF00550
(PP-binding) 		4 GLY A  34
ALA A  35
ASP A  36
ASP A  39
 PNS  A 137 ( 3.2A)
None
PNS  A 137 (-2.3A)
None
 0.71A 4eyrB-2fq0A:
undetectable		 4eyrB-2fq0A:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuk XC6422 PROTEIN

(Xanthomonas
campestris) 		PF12146
(Hydrolase_4) 		4 GLY A 206
ALA A 207
PRO A 191
THR A 193
 None
 0.86A 4eyrB-2fukA:
undetectable		 4eyrB-2fukA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gr7 ADHESIN

(Haemophilus
influenzae) 		PF03895
(YadA_anchor) 		4 ASN A1083
GLY A1027
ALA A1026
ASP A1025
 None
 0.86A 4eyrB-2gr7A:
undetectable		 4eyrB-2gr7A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gr8 ADHESIN

(Haemophilus
influenzae) 		PF03895
(YadA_anchor) 		4 ASN A1083
GLY A1027
ALA A1026
ASP A1025
 None
 0.76A 4eyrB-2gr8A:
undetectable		 4eyrB-2gr8A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF13432
(TPR_16) 		5 ASN A 210
ALA A 185
ASP A 184
ASP A 188
PRO A 519
 None
 1.44A 4eyrB-2gw1A:
undetectable		 4eyrB-2gw1A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hev TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER 4

(Homo sapiens) 		PF00020
(TNFR_c6) 		4 ARG R  65
GLY R  70
ASP R 104
PRO R  80
 None
 0.87A 4eyrB-2hevR:
undetectable		 4eyrB-2hevR:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis) 		PF13419
(HAD_2) 		5 ARG A 103
ASP A   8
ASP A 171
PRO A 164
THR A 167
 None
 1.45A 4eyrB-2i6xA:
undetectable		 4eyrB-2i6xA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)

(Streptomyces
galilaeus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 GLY A 296
ALA A 297
PRO A 226
THR A 227
 None
 0.80A 4eyrB-2ipiA:
undetectable		 4eyrB-2ipiA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iss PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Thermotoga
maritima) 		PF01680
(SOR_SNZ) 		4 GLY A 129
ALA A 130
ASP A 132
PRO A 207
 None
 0.76A 4eyrB-2issA:
undetectable		 4eyrB-2issA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jnc CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
2

(Mus musculus) 		PF02793
(HRM) 		4 ARG A  47
GLY A  55
PRO A  72
THR A  62
 None
 0.78A 4eyrB-2jncA:
undetectable		 4eyrB-2jncA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lli PROTEIN AIR2

(Saccharomyces
cerevisiae) 		PF00098
(zf-CCHC) 		5 GLY A  29
ALA A  30
ASP A  33
ASP A  32
PRO A  21
 None
 1.38A 4eyrB-2lliA:
undetectable		 4eyrB-2lliA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mgv BIFUNCTIONAL
MEMBRANE-ASSOCIATED
PENICILLIN-BINDING
PROTEIN 1A/1B PONA2

(Mycobacterium
tuberculosis) 		PF03793
(PASTA) 		5 GLY A  23
ALA A  22
ASP A  21
PRO A  47
THR A  51
 None
 1.29A 4eyrB-2mgvA:
undetectable		 4eyrB-2mgvA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mt9 FLAVODOXIN-2

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		4 GLY A  94
ASP A  89
ASP A 145
THR A 121
 None
 0.71A 4eyrB-2mt9A:
undetectable		 4eyrB-2mt9A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE

(Homo sapiens) 		PF01053
(Cys_Met_Meta_PP) 		4 GLY A 202
ALA A 203
ASP A 204
THR A 158
 None
 0.47A 4eyrB-2nmpA:
undetectable		 4eyrB-2nmpA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o14 HYPOTHETICAL PROTEIN
YXIM

(Bacillus
subtilis) 		PF13472
(Lipase_GDSL_2) 		4 GLY A 269
ALA A 270
ASP A 271
THR A 161
 None
 0.83A 4eyrB-2o14A:
undetectable		 4eyrB-2o14A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocb RAS-RELATED PROTEIN
RAB-9B

(Homo sapiens) 		PF00071
(Ras) 		4 GLY A  79
ALA A  80
ASP A  81
THR A  63
 None
 0.75A 4eyrB-2ocbA:
undetectable		 4eyrB-2ocbA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 ARG A 186
ASN A 572
GLY A 194
ASP A 196
THR A 576
 None
 1.50A 4eyrB-2okjA:
undetectable		 4eyrB-2okjA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okk GLUTAMATE
DECARBOXYLASE 2

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 ARG A 177
ASN A 563
GLY A 185
ASP A 187
THR A 567
 None
 1.49A 4eyrB-2okkA:
undetectable		 4eyrB-2okkA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ory LIPASE

(Photobacterium
sp. M37) 		PF01764
(Lipase_3) 		4 GLY A 338
ALA A 337
ASP A 334
PRO A  94
 None
 0.76A 4eyrB-2oryA:
undetectable		 4eyrB-2oryA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osy ENDOGLYCOCERAMIDASE
II

(Rhodococcus sp.) 		PF00150
(Cellulase) 		4 GLY A 458
ALA A 459
ASP A 460
PRO A 433
 None
 0.81A 4eyrB-2osyA:
undetectable		 4eyrB-2osyA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph1 NUCLEOTIDE-BINDING
PROTEIN

(Archaeoglobus
fulgidus) 		PF10609
(ParA) 		4 ALA A  55
ASP A  56
ASP A 135
PRO A 153
 None
 0.84A 4eyrB-2ph1A:
undetectable		 4eyrB-2ph1A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjg PUTATIVE ALDOLASE
MJ0400

(Methanocaldococcus
jannaschii) 		PF01791
(DeoC) 		4 GLY A 112
ALA A 113
ASP A 114
THR A 103
 None
 0.86A 4eyrB-2qjgA:
undetectable		 4eyrB-2qjgA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r01 NITROREDUCTASE
FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF00881
(Nitroreductase) 		4 GLY A 108
ALA A 109
ASP A 112
THR A 153
 None
 0.76A 4eyrB-2r01A:
undetectable		 4eyrB-2r01A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbc SUGAR KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		4 ARG A 157
GLY A 177
PRO A 213
THR A 215
 None
 0.84A 4eyrB-2rbcA:
undetectable		 4eyrB-2rbcA:
15.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 ARG A   8
GLY A  27
ALA A  28
ASP A  29
ASP A  30
PRO A  81
 AB1  A 501 ( 4.7A)
AB1  A 501 (-3.9A)
AB1  A 501 (-3.5A)
AB1  A 501 ( 3.3A)
AB1  A 501 (-3.8A)
AB1  A 501 (-4.2A)
 0.41A 4eyrB-2rkfA:
18.9		 4eyrB-2rkfA:
81.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vea PHYTOCHROME-LIKE
PROTEIN CPH1

(Synechocystis
sp. PCC 6803) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 ARG A 165
GLY A 270
ALA A 271
ASP A 226
THR A 168
 None
 1.10A 4eyrB-2veaA:
undetectable		 4eyrB-2veaA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		4 GLY A 363
ASP A 365
ASP A 367
THR A  14
 None
 0.72A 4eyrB-2vhlA:
undetectable		 4eyrB-2vhlA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbp L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
vinaceus) 		PF02668
(TauD) 		4 GLY A 191
ASP A 302
ASP A 305
THR A 195
 None
 0.83A 4eyrB-2wbpA:
undetectable		 4eyrB-2wbpA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnx GLYCOSIDE HYDROLASE,
FAMILY 9

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		4 GLY A  89
ALA A  90
ASP A  91
THR A 147
 None
 0.78A 4eyrB-2wnxA:
undetectable		 4eyrB-2wnxA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wok CLAVULANIC ACID
BIOSYNTHESIS
OLIGOPEPTIDE BINDING
PROTEIN 2

(Streptomyces
clavuligerus) 		PF00496
(SBP_bac_5) 		5 ARG A 300
GLY A 454
ALA A 455
ASP A 456
THR A 355
 None
GOL  A1562 ( 3.6A)
None
None
None
 1.25A 4eyrB-2wokA:
undetectable		 4eyrB-2wokA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE

(Homo sapiens) 		PF00004
(AAA) 		4 GLY A 584
ALA A 585
ASP A 588
PRO A 623
 None
 0.66A 4eyrB-2x8aA:
undetectable		 4eyrB-2x8aA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymv ACG NITROREDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 5 GLY A 253
ALA A 252
ASP A 251
ASP A 248
THR A 274
 None
None
None
None
FNR  A1330 (-3.2A)
 1.44A 4eyrB-2ymvA:
undetectable		 4eyrB-2ymvA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymv ACG NITROREDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 5 GLY A 253
ALA A 252
ASP A 251
ASP A 248
THR A 277
 None
 1.36A 4eyrB-2ymvA:
undetectable		 4eyrB-2ymvA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzw ADP-RIBOSYLGLYCOHYDR
OLASE

(Thermus
thermophilus) 		PF03747
(ADP_ribosyl_GH) 		4 ARG A  11
GLY A 270
ALA A 271
ASP A 237
 None
 0.75A 4eyrB-2yzwA:
undetectable		 4eyrB-2yzwA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zki 199AA LONG
HYPOTHETICAL TRP
REPRESSOR BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF03358
(FMN_red) 		4 ARG A 186
GLY A  32
ALA A  33
PRO A 109
 None
 0.82A 4eyrB-2zkiA:
undetectable		 4eyrB-2zkiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aja PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		PF01083
(Cutinase) 		5 ARG A 250
GLY A 192
ASP A 197
ASP A 199
THR A 261
 None
 1.43A 4eyrB-3ajaA:
undetectable		 4eyrB-3ajaA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)

(Thermus
thermophilus) 		PF14520
(HHH_5)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb) 		4 GLY A 411
ALA A 412
ASP A 373
PRO A 425
 None
 0.86A 4eyrB-3auoA:
undetectable		 4eyrB-3auoA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 GLY A  72
ASP A  67
PRO A  94
THR A  88
 None
 0.72A 4eyrB-3cghA:
undetectable		 4eyrB-3cghA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clq UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF06545
(DUF1116) 		4 ALA A 135
ASP A 134
ASP A 131
PRO A 445
 None
 0.86A 4eyrB-3clqA:
undetectable		 4eyrB-3clqA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbg PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 GLY A 359
ALA A 360
ASP A 361
PRO A  24
 None
 0.54A 4eyrB-3dbgA:
undetectable		 4eyrB-3dbgA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc8 DIHYDROPYRIMIDINASE

(Sinorhizobium
meliloti) 		PF01979
(Amidohydro_1) 		5 GLY A 385
ALA A 386
ASP A 387
ASP A 389
THR A  12
 None
 1.06A 4eyrB-3dc8A:
undetectable		 4eyrB-3dc8A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dev SH1221

(Staphylococcus
haemolyticus) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 ARG A 267
GLY A 284
ALA A 279
ASP A 277
 SO4  A 322 (-4.3A)
None
None
None
 0.83A 4eyrB-3devA:
undetectable		 4eyrB-3devA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE

(Bacillus cereus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ARG A  89
GLY A  98
ALA A  99
PRO A  80
 None
 0.83A 4eyrB-3dhvA:
undetectable		 4eyrB-3dhvA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9d ZGC:56074

(Danio rerio) 		PF00300
(His_Phos_1) 		5 ARG A 238
GLY A 170
ALA A 171
ASP A 168
THR A   3
 None
 1.17A 4eyrB-3e9dA:
undetectable		 4eyrB-3e9dA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emo HIA (ADHESIN)

(Haemophilus
influenzae) 		no annotation 4 ASN C1083
GLY C1027
ALA C1026
ASP C1025
 None
 0.86A 4eyrB-3emoC:
undetectable		 4eyrB-3emoC:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		4 GLY A  87
ALA A  88
ASP A  89
THR A 225
 None
 0.80A 4eyrB-3g8mA:
undetectable		 4eyrB-3g8mA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goc ENDONUCLEASE V

(Streptomyces
avermitilis) 		PF04493
(Endonuclease_5) 		4 GLY A  38
ALA A  65
ASP A  64
PRO A 137
 None
 0.88A 4eyrB-3gocA:
undetectable		 4eyrB-3gocA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gt7 SENSOR PROTEIN

(Syntrophus
aciditrophicus) 		PF00072
(Response_reg) 		4 ARG A 102
GLY A 107
ALA A 108
ASP A 109
 None
 0.53A 4eyrB-3gt7A:
undetectable		 4eyrB-3gt7A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3y CARBOHYDRATE KINASE

(Klebsiella
pneumoniae) 		PF00294
(PfkB) 		4 ARG A  55
GLY A  40
ALA A  41
PRO A  77
 None
 0.86A 4eyrB-3i3yA:
undetectable		 4eyrB-3i3yA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwp COPPER HOMEOSTASIS
PROTEIN CUTC HOMOLOG

(Homo sapiens) 		PF03932
(CutC) 		4 GLY A 110
ALA A 111
ASP A 112
THR A  61
 None
 0.77A 4eyrB-3iwpA:
undetectable		 4eyrB-3iwpA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4s FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		4 ASN A  35
GLY A  29
ALA A  57
ASP A  75
 None
 0.77A 4eyrB-3j4sA:
undetectable		 4eyrB-3j4sA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzy INTERSECTIN 2

(Homo sapiens) 		PF00168
(C2) 		4 GLY A1560
ASP A1610
PRO A1650
THR A1651
 None
 0.71A 4eyrB-3jzyA:
undetectable		 4eyrB-3jzyA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2k PUTATIVE
CARBOXYPEPTIDASE

(Burkholderia
mallei) 		PF00246
(Peptidase_M14) 		5 ARG A 144
ASN A 228
GLY A 231
ALA A 232
THR A 140
 None
 1.38A 4eyrB-3k2kA:
undetectable		 4eyrB-3k2kA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg7 CURH

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		4 ARG A1191
GLY A1210
PRO A1143
THR A1142
 None
 0.76A 4eyrB-3kg7A:
undetectable		 4eyrB-3kg7A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A

(Streptococcus
mutans) 		PF06026
(Rib_5-P_isom_A) 		4 ARG A 209
GLY A  83
ALA A  84
ASP A  85
 None
 0.69A 4eyrB-3l7oA:
undetectable		 4eyrB-3l7oA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III

(Rhodopseudomonas
palustris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 GLY A 334
ALA A 333
PRO A  14
THR A  13
 None
 0.81A 4eyrB-3ledA:
undetectable		 4eyrB-3ledA:
13.87