SIMILAR PATTERNS OF AMINO ACIDS FOR 4EYR_B_RITB301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1at0 17-HEDGEHOG

(Drosophila
melanogaster) 		PF01079
(Hint) 		4 LEU A 323
ALA A 346
ASP A 347
VAL A 373
 None
 0.92A 4eyrA-1at0A:
0.0		 4eyrA-1at0A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 LEU A  90
ALA A  85
VAL A  26
ILE A 268
 None
 0.97A 4eyrA-1c3lA:
0.0		 4eyrA-1c3lA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9k ADENOSYLCOBINAMIDE
KINASE

(Salmonella
enterica) 		PF02283
(CobU) 		4 ALA A 165
ASP A 166
ILE A  77
THR A   5
 None
 0.62A 4eyrA-1c9kA:
undetectable		 4eyrA-1c9kA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clx XYLANASE A

(Cellvibrio
japonicus) 		PF00331
(Glyco_hydro_10) 		4 LEU A   2
ALA A   6
ASP A   7
ILE A 242
 None
 0.99A 4eyrA-1clxA:
0.0		 4eyrA-1clxA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0r THERMOSOME

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		4 ALA B 235
ASP B 234
VAL B 231
THR B 359
 None
 0.98A 4eyrA-1e0rB:
undetectable		 4eyrA-1e0rB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5u INTIMIN

(Escherichia
coli) 		PF02368
(Big_2)
PF07979
(Intimin_C) 		4 LEU I  62
ASP I  54
ILE I   4
THR I  68
 None
 0.93A 4eyrA-1e5uI:
0.0		 4eyrA-1e5uI:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7c ELONGATION FACTOR
1-ALPHA

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 LEU A 374
ASN A 339
VAL A 342
ILE A 366
 None
 0.95A 4eyrA-1g7cA:
0.0		 4eyrA-1g7cA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ALA A  50
ASP A  49
ILE A  79
THR A  28
 None
 0.82A 4eyrA-1gg4A:
0.0		 4eyrA-1gg4A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 226
ASP A 425
VAL A 422
ILE A 237
 None
 0.83A 4eyrA-1hfuA:
0.0		 4eyrA-1hfuA:
11.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
ALA A  28
ASP A  29
VAL A  32
 A79  A 800 ( 3.8A)
A79  A 800 (-3.1A)
A79  A 800 (-2.8A)
A79  A 800 ( 4.4A)
 0.39A 4eyrA-1hvcA:
12.5		 4eyrA-1hvcA:
43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
ALA A  28
ASP A  29
VAL A  32
 A79  A 800 ( 4.0A)
A79  A 800 (-3.2A)
A79  A 800 (-2.7A)
A79  A 800 ( 4.3A)
 0.36A 4eyrA-1hvcA:
12.5		 4eyrA-1hvcA:
43.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Streptococcus
mutans) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 LEU A  38
ALA A  15
ASP A  14
ILE A 138
 None
MN  A 401 ( 4.1A)
MN  A 402 (-3.3A)
None
 0.81A 4eyrA-1i74A:
undetectable		 4eyrA-1i74A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia7 CELLULASE CEL9M

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9) 		4 LEU A 332
ALA A 310
VAL A 337
ILE A  73
 None
 0.95A 4eyrA-1ia7A:
undetectable		 4eyrA-1ia7A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermotoga
maritima) 		PF00218
(IGPS) 		4 LEU A  97
ALA A 103
ASP A 104
ILE A  46
 None
 0.91A 4eyrA-1j5tA:
undetectable		 4eyrA-1j5tA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jlv GLUTATHIONE
TRANSFERASE GST1-3

(Anopheles
cracens) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A 152
ASP A 100
VAL A  93
ILE A  68
 None
 0.91A 4eyrA-1jlvA:
undetectable		 4eyrA-1jlvA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jya YOPE REGULATOR

(Yersinia
pseudotuberculosis) 		PF05932
(CesT) 		5 LEU A  74
ASN A  91
VAL A 111
ILE A  27
THR A 105
 None
 1.33A 4eyrA-1jyaA:
undetectable		 4eyrA-1jyaA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Streptococcus
gordonii) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 LEU A  40
ALA A  16
ASP A  15
ILE A 140
 None
MN  A 701 ( 4.0A)
MN  A 702 (-3.1A)
None
 0.82A 4eyrA-1k20A:
undetectable		 4eyrA-1k20A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 ALA A 726
ASP A 725
VAL A 833
THR A 828
 None
 0.99A 4eyrA-1l5jA:
undetectable		 4eyrA-1l5jA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus) 		PF02332
(Phenol_Hydrox) 		4 LEU B 332
ALA B 227
VAL B 223
ILE B 193
 None
 0.97A 4eyrA-1mtyB:
undetectable		 4eyrA-1mtyB:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE

(Arabidopsis
thaliana) 		PF16363
(GDP_Man_Dehyd) 		4 LEU A 138
ALA A 191
VAL A 133
ILE A 211
 None
 0.95A 4eyrA-1n7gA:
undetectable		 4eyrA-1n7gA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1omo ALANINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF02423
(OCD_Mu_crystall) 		4 LEU A 191
ALA A 215
ILE A 259
THR A 211
 LEU  A 191 ( 0.6A)
ALA  A 215 ( 0.0A)
ILE  A 259 ( 0.6A)
THR  A 211 ( 0.8A)
 0.96A 4eyrA-1omoA:
undetectable		 4eyrA-1omoA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ooe DIHYDROPTERIDINE
REDUCTASE

(Caenorhabditis
elegans) 		PF00106
(adh_short) 		4 ASN A  38
ALA A  41
ASP A  42
VAL A   8
 None
 0.98A 4eyrA-1ooeA:
undetectable		 4eyrA-1ooeA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn9 GLUTATHIONE
S-TRANSFERASE 1-6

(Anopheles
gambiae) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A 152
ASP A 100
VAL A  93
ILE A  68
 None
 0.97A 4eyrA-1pn9A:
undetectable		 4eyrA-1pn9A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		4 ASN L 183
ALA M 213
VAL L 241
ILE L 117
 None
BPH  L 271 ( 3.7A)
BPH  L 271 (-4.3A)
BPH  L 271 (-4.9A)
 0.77A 4eyrA-1pssL:
undetectable		 4eyrA-1pssL:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 LEU A 266
ALA A 183
VAL A 180
ILE A 260
 SND  A 500 (-3.6A)
None
None
None
 0.96A 4eyrA-1ptjA:
undetectable		 4eyrA-1ptjA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs1 ADP-RIBOSYLTRANSFERA
SE

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox) 		4 LEU A 262
ASP A 267
ILE A 129
THR A 219
 None
 0.91A 4eyrA-1qs1A:
undetectable		 4eyrA-1qs1A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2j PROTEIN FKBI

(Streptomyces
hygroscopicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ALA A 107
ASP A 150
VAL A 167
THR A  84
 None
 0.97A 4eyrA-1r2jA:
undetectable		 4eyrA-1r2jA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5e MULTIDRUG RESISTANCE
PROTEIN MEXA

(Pseudomonas
aeruginosa) 		PF00529
(HlyD)
PF16576
(HlyD_D23) 		5 LEU A 249
ASN A 244
VAL A 241
ILE A 141
THR A  35
 None
 1.45A 4eyrA-1t5eA:
undetectable		 4eyrA-1t5eA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF

(Pseudomonas
fluorescens) 		PF02567
(PhzC-PhzF) 		4 LEU A 176
ALA A 183
VAL A 205
ILE A 236
 None
 0.91A 4eyrA-1t6kA:
undetectable		 4eyrA-1t6kA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 LEU A 565
ASN A 566
ALA A 608
ILE A 660
 None
 0.98A 4eyrA-1u1hA:
undetectable		 4eyrA-1u1hA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udd TRANSCRIPTIONAL
REGULATOR

(Pyrococcus
horikoshii) 		PF03070
(TENA_THI-4) 		4 LEU A  50
ALA A 101
ASP A 100
VAL A  43
 None
 0.99A 4eyrA-1uddA:
undetectable		 4eyrA-1uddA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 LEU A 476
ASP A 383
ILE A 757
THR A 742
 None
 0.90A 4eyrA-1ut9A:
undetectable		 4eyrA-1ut9A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Thermus
thermophilus) 		PF01070
(FMN_dh) 		4 LEU A 140
ALA A 146
ASP A 147
ILE A  63
 None
 0.91A 4eyrA-1vcgA:
undetectable		 4eyrA-1vcgA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE

(Thermotoga
maritima) 		PF01207
(Dus) 		4 LEU A  23
ALA A  29
ASP A  30
ILE A 192
 None
None
None
FMN  A 322 (-4.7A)
 0.87A 4eyrA-1vhnA:
undetectable		 4eyrA-1vhnA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we0 ALKYL HYDROPEROXIDE
REDUCTASE C

(Amphibacillus
xylanus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 ALA A  41
ASP A  42
ILE A 104
THR A 115
 None
 0.88A 4eyrA-1we0A:
undetectable		 4eyrA-1we0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 382
ASN A 321
ALA A 323
ILE A 146
 CSO  A  92 ( 3.9A)
None
COA  A1001 ( 3.8A)
None
 0.98A 4eyrA-1wl4A:
undetectable		 4eyrA-1wl4A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 LEU A 117
ALA A 133
ILE A 220
THR A 180
 None
 0.82A 4eyrA-1xc6A:
undetectable		 4eyrA-1xc6A:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfa CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Mus musculus) 		PF00005
(ABC_tran)
PF14396
(CFTR_R) 		4 LEU A 570
ALA A 566
ASP A 565
VAL A 562
 None
 0.87A 4eyrA-1xfaA:
undetectable		 4eyrA-1xfaA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfk FORMIMIDOYLGLUTAMASE

(Vibrio cholerae) 		PF00491
(Arginase) 		4 LEU A 255
ALA A  65
ASP A  53
ILE A  93
 None
 0.97A 4eyrA-1xfkA:
undetectable		 4eyrA-1xfkA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 LEU A  99
ASN A  96
VAL A  48
ILE A  22
 None
 0.88A 4eyrA-1xjeA:
undetectable		 4eyrA-1xjeA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Homo sapiens) 		PF00005
(ABC_tran)
PF14396
(CFTR_R) 		4 LEU A 570
ALA A 566
ASP A 565
VAL A 562
 None
 0.91A 4eyrA-1xmjA:
undetectable		 4eyrA-1xmjA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		5 LEU A  22
ALA A   7
VAL A  52
ILE A  39
THR A  21
 None
 1.27A 4eyrA-1xw8A:
undetectable		 4eyrA-1xw8A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE

(Salmonella
enterica) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 ALA A  43
VAL A  46
ILE A  58
THR A  30
 None
 0.77A 4eyrA-1yb4A:
undetectable		 4eyrA-1yb4A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YIAJ

(Escherichia
coli) 		PF01614
(IclR) 		4 LEU A  94
ASN A 124
ILE A  70
THR A  98
 None
 0.99A 4eyrA-1ysqA:
undetectable		 4eyrA-1ysqA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA

(Mycobacterium
tuberculosis) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 ASP A 399
VAL A 361
ILE A 349
THR A 356
 None
 0.79A 4eyrA-1zj9A:
undetectable		 4eyrA-1zj9A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzw DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00782
(DSPc) 		4 LEU A 358
ALA A 337
ILE A 325
THR A 355
 None
 0.99A 4eyrA-1zzwA:
undetectable		 4eyrA-1zzwA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aja ANKYRIN REPEAT
FAMILY PROTEIN

(Legionella
pneumophila) 		no annotation 4 LEU A 329
ASN A 331
ALA A 334
ILE A 306
 None
 0.92A 4eyrA-2ajaA:
undetectable		 4eyrA-2ajaA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8t THYMIDINE KINASE

(Ureaplasma
parvum) 		PF00265
(TK) 		4 ALA A 143
ASP A 144
ILE A  93
THR A  18
 None
 0.77A 4eyrA-2b8tA:
undetectable		 4eyrA-2b8tA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch9 CYSTATIN F

(Homo sapiens) 		PF00031
(Cystatin) 		4 LEU A  69
ASN A  61
ILE A  75
THR A  97
 None
 0.96A 4eyrA-2ch9A:
undetectable		 4eyrA-2ch9A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4v ISOCITRATE
DEHYDROGENASE

(Acidithiobacillus
thiooxidans) 		PF00180
(Iso_dh) 		4 LEU A 315
ALA A 295
ASP A 296
VAL A 322
 None
 0.99A 4eyrA-2d4vA:
undetectable		 4eyrA-2d4vA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dld D-LACTATE
DEHYDROGENASE

(Lactobacillus
helveticus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A  43
ALA A  47
ASP A  48
THR A  32
 None
 0.85A 4eyrA-2dldA:
undetectable		 4eyrA-2dldA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9y CARBAMATE KINASE

(Aeropyrum
pernix) 		PF00696
(AA_kinase) 		5 LEU A 223
ALA A 229
ASP A 230
VAL A 233
THR A  52
 None
 1.13A 4eyrA-2e9yA:
undetectable		 4eyrA-2e9yA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Aquifex
aeolicus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 141
ALA A 270
ILE A  76
THR A  81
 None
 0.97A 4eyrA-2ebdA:
undetectable		 4eyrA-2ebdA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efe SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana) 		PF00071
(Ras) 		4 ALA B 138
ASP B 137
VAL B  92
THR B 152
 None
 0.97A 4eyrA-2efeB:
undetectable		 4eyrA-2efeB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egg SHIKIMATE
5-DEHYDROGENASE

(Geobacillus
kaustophilus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ASN A 172
ALA A 178
VAL A 146
THR A 212
 None
 0.98A 4eyrA-2eggA:
undetectable		 4eyrA-2eggA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Aquifex
aeolicus) 		PF00290
(Trp_syntA) 		4 ALA A 228
ASP A 229
VAL A 232
ILE A 166
 None
 0.92A 4eyrA-2ekcA:
undetectable		 4eyrA-2ekcA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2euh NADP DEPENDENT NON
PHOSPHORYLATING
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Streptococcus
mutans) 		PF00171
(Aldedh) 		4 ALA A 175
VAL A  42
ILE A 238
THR A 207
 None
 0.94A 4eyrA-2euhA:
undetectable		 4eyrA-2euhA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 ALA A 373
ASP A 372
VAL A 363
ILE A 407
 None
 0.90A 4eyrA-2eyqA:
undetectable		 4eyrA-2eyqA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 LEU A 212
ALA A 192
VAL A  55
THR A 214
 None
None
None
FAD  A1000 (-4.2A)
 0.87A 4eyrA-2fjaA:
undetectable		 4eyrA-2fjaA:
8.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE

(Equine
infectious
anemia virus) 		PF00077
(RVP) 		4 LEU A  23
ALA A  28
ASP A  29
VAL A  32
 None
LP1  A 201 (-3.5A)
LP1  A 201 (-3.6A)
None
 0.27A 4eyrA-2fmbA:
13.9		 4eyrA-2fmbA:
30.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB

(Methanocaldococcus
jannaschii) 		PF02492
(cobW) 		4 ALA A 161
ASP A 162
VAL A 165
ILE A 119
 None
 0.62A 4eyrA-2hf8A:
undetectable		 4eyrA-2hf8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00288
(GHMP_kinases_N) 		4 LEU A 303
ALA A 289
VAL A 185
ILE A  17
 None
 0.97A 4eyrA-2hkeA:
undetectable		 4eyrA-2hkeA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i96 CYTOCHROME B5

(Homo sapiens) 		PF00173
(Cyt-b5) 		4 LEU A  71
ALA A  79
ASP A  78
THR A  46
 None
HEM  A 129 ( 3.1A)
None
None
 0.96A 4eyrA-2i96A:
undetectable		 4eyrA-2i96A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ig8 HYPOTHETICAL PROTEIN
PA3499

(Pseudomonas
aeruginosa) 		PF01042
(Ribonuc_L-PSP) 		4 LEU A  67
ALA A 130
VAL A  75
ILE A  94
 None
 0.96A 4eyrA-2ig8A:
undetectable		 4eyrA-2ig8A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n03 PLECTIN

(Homo sapiens) 		PF00681
(Plectin) 		4 LEU A4449
ALA A4472
ASP A4471
VAL A4483
 None
 0.90A 4eyrA-2n03A:
undetectable		 4eyrA-2n03A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 LEU A 238
ASN A 156
VAL A 135
ILE A 318
 None
 0.98A 4eyrA-2np0A:
undetectable		 4eyrA-2np0A:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 ALA A 289
VAL A 259
ILE A 314
THR A 283
 ALA  A 289 ( 0.0A)
VAL  A 259 ( 0.6A)
ILE  A 314 ( 0.4A)
THR  A 283 ( 0.8A)
 0.89A 4eyrA-2nvvA:
undetectable		 4eyrA-2nvvA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00275
(EPSP_synthase) 		4 ALA A 380
ASP A 383
ILE A 392
THR A   3
 None
 0.96A 4eyrA-2o0xA:
undetectable		 4eyrA-2o0xA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o57 PUTATIVE SARCOSINE
DIMETHYLGLYCINE
METHYLTRANSFERASE

(Galdieria
sulphuraria) 		PF08241
(Methyltransf_11) 		4 LEU A 130
ALA A  97
ASP A  88
ILE A  45
 None
 0.90A 4eyrA-2o57A:
undetectable		 4eyrA-2o57A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohw YUEI PROTEIN

(Bacillus
subtilis) 		PF07997
(DUF1694) 		4 LEU A  29
ALA A  39
ILE A 124
THR A 101
 None
 0.91A 4eyrA-2ohwA:
undetectable		 4eyrA-2ohwA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi2 MEVALONATE KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 LEU A 275
ALA A 167
ASP A 168
ILE A  15
 None
 0.95A 4eyrA-2oi2A:
undetectable		 4eyrA-2oi2A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozv HYPOTHETICAL PROTEIN
ATU0636

(Agrobacterium
fabrum) 		PF05175
(MTS) 		4 LEU A 119
ALA A  49
ILE A 177
THR A 163
 None
 0.92A 4eyrA-2ozvA:
undetectable		 4eyrA-2ozvA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1

(Pyrococcus
abyssi) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 LEU A 201
ALA A 219
VAL A 138
ILE A 167
 None
 0.95A 4eyrA-2pnzA:
undetectable		 4eyrA-2pnzA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt5 SHIKIMATE KINASE

(Aquifex
aeolicus) 		PF01202
(SKI) 		4 ALA A 140
ASP A 141
VAL A 144
ILE A  74
 None
 0.60A 4eyrA-2pt5A:
undetectable		 4eyrA-2pt5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		4 ASN A 393
ASP A 386
ILE A 208
THR A 370
 None
 0.98A 4eyrA-2pyxA:
undetectable		 4eyrA-2pyxA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzf CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Homo sapiens) 		PF00005
(ABC_tran) 		4 LEU A 570
ALA A 566
ASP A 565
VAL A 562
 None
 0.74A 4eyrA-2pzfA:
undetectable		 4eyrA-2pzfA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q74 INOSITOL-1-MONOPHOSP
HATASE

(Mycobacterium
tuberculosis) 		PF00459
(Inositol_P) 		5 LEU A 155
ASP A 214
VAL A 136
ILE A 116
THR A 143
 None
 1.39A 4eyrA-2q74A:
undetectable		 4eyrA-2q74A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Aromatoleum
aromaticum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 365
ALA A 306
VAL A 349
ILE A  31
 None
 0.92A 4eyrA-2qdeA:
undetectable		 4eyrA-2qdeA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7a BACTERIAL HEME
BINDING PROTEIN

(Shigella
dysenteriae) 		PF01497
(Peripla_BP_2) 		4 LEU A 167
ALA A 183
VAL A 218
THR A 220
 None
HEM  A 600 (-3.9A)
None
None
 0.87A 4eyrA-2r7aA:
undetectable		 4eyrA-2r7aA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 212
ASP A 216
VAL A 136
ILE A 195
 None
ANP  A1480 (-3.5A)
None
None
 0.90A 4eyrA-2v55A:
undetectable		 4eyrA-2v55A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc6 DIHYDRODIPICOLINATE
SYNTHASE

(Sinorhizobium
meliloti) 		PF00701
(DHDPS) 		4 ALA A 163
ASP A 162
ILE A 114
THR A  43
 MCL  A 161 ( 4.6A)
None
None
MCL  A 161 ( 4.6A)
 0.84A 4eyrA-2vc6A:
undetectable		 4eyrA-2vc6A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkn FORMAMIDASE

(Delftia
acidovorans) 		PF03069
(FmdA_AmdA) 		4 LEU A 306
ALA A 335
VAL A 358
THR A 379
 None
 0.98A 4eyrA-2wknA:
undetectable		 4eyrA-2wknA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)

(Archaeoglobus
fulgidus) 		PF02492
(cobW) 		4 ALA A 156
ASP A 157
VAL A 160
ILE A 114
 None
 0.66A 4eyrA-2wsmA:
undetectable		 4eyrA-2wsmA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsu PUTATIVE FIBER
PROTEIN

(Porcine
mastadenovirus
B) 		PF00337
(Gal-bind_lectin) 		4 LEU A 663
ALA A 591
ILE A 620
THR A 639
 None
 0.90A 4eyrA-2wsuA:
undetectable		 4eyrA-2wsuA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 ASN A 854
VAL A 851
ILE A 886
THR A 818
 None
 0.98A 4eyrA-2x05A:
undetectable		 4eyrA-2x05A:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		4 LEU A 504
ALA A 101
ASP A 103
VAL A  95
 None
 0.93A 4eyrA-2yevA:
undetectable		 4eyrA-2yevA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 260
ALA A 276
ASP A 273
ILE A 301
 None
 0.95A 4eyrA-2z63A:
undetectable		 4eyrA-2z63A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acz METHIONINE
GAMMA-LYASE

(Entamoeba
histolytica) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A 189
ALA A 196
ASP A 197
ILE A 102
 None
 0.72A 4eyrA-3aczA:
undetectable		 4eyrA-3aczA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		4 ALA A 404
VAL A 303
ILE A 389
THR A 358
 None
 0.83A 4eyrA-3afgA:
undetectable		 4eyrA-3afgA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aj6 MAIN HEMAGGLUTININ
COMPONENT

(Clostridium
botulinum) 		no annotation 5 LEU A 158
ASN A 278
ASP A 271
VAL A 268
THR A 156
 None
 1.38A 4eyrA-3aj6A:
undetectable		 4eyrA-3aj6A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1r RIBOKINASE, PUTATIVE

(Burkholderia
thailandensis) 		PF00294
(PfkB) 		4 LEU A 282
ALA A 254
ASP A 253
ILE A 218
 None
None
AMP  A 501 (-2.8A)
None
 0.96A 4eyrA-3b1rA:
undetectable		 4eyrA-3b1rA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2n UNCHARACTERIZED
PROTEIN Q99UF4

(Staphylococcus
aureus) 		PF00072
(Response_reg) 		4 ASP A 101
VAL A 104
ILE A   7
THR A  84
 None
 0.91A 4eyrA-3b2nA:
undetectable		 4eyrA-3b2nA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5q PUTATIVE SULFATASE
YIDJ

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 ASP A  24
VAL A 256
ILE A  20
THR A  41
 None
 0.96A 4eyrA-3b5qA:
undetectable		 4eyrA-3b5qA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE

(Methanocaldococcus
jannaschii) 		PF03587
(EMG1) 		4 LEU A 129
ALA A 135
VAL A 176
ILE A 183
 None
 0.90A 4eyrA-3bbhA:
undetectable		 4eyrA-3bbhA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I

(Bacillus
anthracis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ASN A 259
ALA A 263
VAL A 266
ILE A 299
 None
None
None
FAD  A 446 ( 4.0A)
 0.77A 4eyrA-3cgdA:
undetectable		 4eyrA-3cgdA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION

(Ruegeria
pomeroyi) 		no annotation 4 LEU A 194
ALA A 140
VAL A 163
THR A 197
 None
 0.92A 4eyrA-3cvoA:
undetectable		 4eyrA-3cvoA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N) 		4 LEU A 315
ALA A 301
VAL A 197
ILE A  21
 None
 0.95A 4eyrA-3d4jA:
undetectable		 4eyrA-3d4jA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6b GLUTARYL-COA
DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ALA A 176
ASP A 177
VAL A 107
ILE A  54
 None
 0.98A 4eyrA-3d6bA:
undetectable		 4eyrA-3d6bA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE

(Cytophaga
hutchinsonii) 		PF00682
(HMGL-like) 		4 ALA A 210
VAL A 244
ILE A 168
THR A 228
 None
 0.96A 4eyrA-3eegA:
undetectable		 4eyrA-3eegA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN

([Eubacterium]
rectale) 		PF13614
(AAA_31) 		5 LEU A 195
ASN A 192
ALA A 191
VAL A 106
ILE A  81
 None
 1.39A 4eyrA-3fkqA:
undetectable		 4eyrA-3fkqA:
12.81