SIMILAR PATTERNS OF AMINO ACIDS FOR 4EYR_B_RITB301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1at0 17-HEDGEHOG

(Drosophila
melanogaster) 		PF01079
(Hint) 		4 LEU A 323
ALA A 346
ASP A 347
VAL A 373
 None
 0.92A 4eyrA-1at0A:
0.0		 4eyrA-1at0A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 LEU A  90
ALA A  85
VAL A  26
ILE A 268
 None
 0.97A 4eyrA-1c3lA:
0.0		 4eyrA-1c3lA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9k ADENOSYLCOBINAMIDE
KINASE

(Salmonella
enterica) 		PF02283
(CobU) 		4 ALA A 165
ASP A 166
ILE A  77
THR A   5
 None
 0.62A 4eyrA-1c9kA:
undetectable		 4eyrA-1c9kA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clx XYLANASE A

(Cellvibrio
japonicus) 		PF00331
(Glyco_hydro_10) 		4 LEU A   2
ALA A   6
ASP A   7
ILE A 242
 None
 0.99A 4eyrA-1clxA:
0.0		 4eyrA-1clxA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0r THERMOSOME

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		4 ALA B 235
ASP B 234
VAL B 231
THR B 359
 None
 0.98A 4eyrA-1e0rB:
undetectable		 4eyrA-1e0rB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5u INTIMIN

(Escherichia
coli) 		PF02368
(Big_2)
PF07979
(Intimin_C) 		4 LEU I  62
ASP I  54
ILE I   4
THR I  68
 None
 0.93A 4eyrA-1e5uI:
0.0		 4eyrA-1e5uI:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7c ELONGATION FACTOR
1-ALPHA

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 LEU A 374
ASN A 339
VAL A 342
ILE A 366
 None
 0.95A 4eyrA-1g7cA:
0.0		 4eyrA-1g7cA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ALA A  50
ASP A  49
ILE A  79
THR A  28
 None
 0.82A 4eyrA-1gg4A:
0.0		 4eyrA-1gg4A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 226
ASP A 425
VAL A 422
ILE A 237
 None
 0.83A 4eyrA-1hfuA:
0.0		 4eyrA-1hfuA:
11.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
ALA A  28
ASP A  29
VAL A  32
 A79  A 800 ( 3.8A)
A79  A 800 (-3.1A)
A79  A 800 (-2.8A)
A79  A 800 ( 4.4A)
 0.39A 4eyrA-1hvcA:
12.5		 4eyrA-1hvcA:
43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
ALA A  28
ASP A  29
VAL A  32
 A79  A 800 ( 4.0A)
A79  A 800 (-3.2A)
A79  A 800 (-2.7A)
A79  A 800 ( 4.3A)
 0.36A 4eyrA-1hvcA:
12.5		 4eyrA-1hvcA:
43.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Streptococcus
mutans) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 LEU A  38
ALA A  15
ASP A  14
ILE A 138
 None
MN  A 401 ( 4.1A)
MN  A 402 (-3.3A)
None
 0.81A 4eyrA-1i74A:
undetectable		 4eyrA-1i74A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia7 CELLULASE CEL9M

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9) 		4 LEU A 332
ALA A 310
VAL A 337
ILE A  73
 None
 0.95A 4eyrA-1ia7A:
undetectable		 4eyrA-1ia7A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermotoga
maritima) 		PF00218
(IGPS) 		4 LEU A  97
ALA A 103
ASP A 104
ILE A  46
 None
 0.91A 4eyrA-1j5tA:
undetectable		 4eyrA-1j5tA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jlv GLUTATHIONE
TRANSFERASE GST1-3

(Anopheles
cracens) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A 152
ASP A 100
VAL A  93
ILE A  68
 None
 0.91A 4eyrA-1jlvA:
undetectable		 4eyrA-1jlvA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jya YOPE REGULATOR

(Yersinia
pseudotuberculosis) 		PF05932
(CesT) 		5 LEU A  74
ASN A  91
VAL A 111
ILE A  27
THR A 105
 None
 1.33A 4eyrA-1jyaA:
undetectable		 4eyrA-1jyaA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Streptococcus
gordonii) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 LEU A  40
ALA A  16
ASP A  15
ILE A 140
 None
MN  A 701 ( 4.0A)
MN  A 702 (-3.1A)
None
 0.82A 4eyrA-1k20A:
undetectable		 4eyrA-1k20A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 ALA A 726
ASP A 725
VAL A 833
THR A 828
 None
 0.99A 4eyrA-1l5jA:
undetectable		 4eyrA-1l5jA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus) 		PF02332
(Phenol_Hydrox) 		4 LEU B 332
ALA B 227
VAL B 223
ILE B 193
 None
 0.97A 4eyrA-1mtyB:
undetectable		 4eyrA-1mtyB:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE

(Arabidopsis
thaliana) 		PF16363
(GDP_Man_Dehyd) 		4 LEU A 138
ALA A 191
VAL A 133
ILE A 211
 None
 0.95A 4eyrA-1n7gA:
undetectable		 4eyrA-1n7gA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1omo ALANINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF02423
(OCD_Mu_crystall) 		4 LEU A 191
ALA A 215
ILE A 259
THR A 211
 LEU  A 191 ( 0.6A)
ALA  A 215 ( 0.0A)
ILE  A 259 ( 0.6A)
THR  A 211 ( 0.8A)
 0.96A 4eyrA-1omoA:
undetectable		 4eyrA-1omoA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ooe DIHYDROPTERIDINE
REDUCTASE

(Caenorhabditis
elegans) 		PF00106
(adh_short) 		4 ASN A  38
ALA A  41
ASP A  42
VAL A   8
 None
 0.98A 4eyrA-1ooeA:
undetectable		 4eyrA-1ooeA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn9 GLUTATHIONE
S-TRANSFERASE 1-6

(Anopheles
gambiae) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A 152
ASP A 100
VAL A  93
ILE A  68
 None
 0.97A 4eyrA-1pn9A:
undetectable		 4eyrA-1pn9A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		4 ASN L 183
ALA M 213
VAL L 241
ILE L 117
 None
BPH  L 271 ( 3.7A)
BPH  L 271 (-4.3A)
BPH  L 271 (-4.9A)
 0.77A 4eyrA-1pssL:
undetectable		 4eyrA-1pssL:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 LEU A 266
ALA A 183
VAL A 180
ILE A 260
 SND  A 500 (-3.6A)
None
None
None
 0.96A 4eyrA-1ptjA:
undetectable		 4eyrA-1ptjA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs1 ADP-RIBOSYLTRANSFERA
SE

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox) 		4 LEU A 262
ASP A 267
ILE A 129
THR A 219
 None
 0.91A 4eyrA-1qs1A:
undetectable		 4eyrA-1qs1A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2j PROTEIN FKBI

(Streptomyces
hygroscopicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ALA A 107
ASP A 150
VAL A 167
THR A  84
 None
 0.97A 4eyrA-1r2jA:
undetectable		 4eyrA-1r2jA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5e MULTIDRUG RESISTANCE
PROTEIN MEXA

(Pseudomonas
aeruginosa) 		PF00529
(HlyD)
PF16576
(HlyD_D23) 		5 LEU A 249
ASN A 244
VAL A 241
ILE A 141
THR A  35
 None
 1.45A 4eyrA-1t5eA:
undetectable		 4eyrA-1t5eA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF

(Pseudomonas
fluorescens) 		PF02567
(PhzC-PhzF) 		4 LEU A 176
ALA A 183
VAL A 205
ILE A 236
 None
 0.91A 4eyrA-1t6kA:
undetectable		 4eyrA-1t6kA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 LEU A 565
ASN A 566
ALA A 608
ILE A 660
 None
 0.98A 4eyrA-1u1hA:
undetectable		 4eyrA-1u1hA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udd TRANSCRIPTIONAL
REGULATOR

(Pyrococcus
horikoshii) 		PF03070
(TENA_THI-4) 		4 LEU A  50
ALA A 101
ASP A 100
VAL A  43
 None
 0.99A 4eyrA-1uddA:
undetectable		 4eyrA-1uddA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 LEU A 476
ASP A 383
ILE A 757
THR A 742
 None
 0.90A 4eyrA-1ut9A:
undetectable		 4eyrA-1ut9A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Thermus
thermophilus) 		PF01070
(FMN_dh) 		4 LEU A 140
ALA A 146
ASP A 147
ILE A  63
 None
 0.91A 4eyrA-1vcgA:
undetectable		 4eyrA-1vcgA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE

(Thermotoga
maritima) 		PF01207
(Dus) 		4 LEU A  23
ALA A  29
ASP A  30
ILE A 192
 None
None
None
FMN  A 322 (-4.7A)
 0.87A 4eyrA-1vhnA:
undetectable		 4eyrA-1vhnA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we0 ALKYL HYDROPEROXIDE
REDUCTASE C

(Amphibacillus
xylanus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 ALA A  41
ASP A  42
ILE A 104
THR A 115
 None
 0.88A 4eyrA-1we0A:
undetectable		 4eyrA-1we0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 382
ASN A 321
ALA A 323
ILE A 146
 CSO  A  92 ( 3.9A)
None
COA  A1001 ( 3.8A)
None
 0.98A 4eyrA-1wl4A:
undetectable		 4eyrA-1wl4A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 LEU A 117
ALA A 133
ILE A 220
THR A 180
 None
 0.82A 4eyrA-1xc6A:
undetectable		 4eyrA-1xc6A:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfa CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Mus musculus) 		PF00005
(ABC_tran)
PF14396
(CFTR_R) 		4 LEU A 570
ALA A 566
ASP A 565
VAL A 562
 None
 0.87A 4eyrA-1xfaA:
undetectable		 4eyrA-1xfaA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfk FORMIMIDOYLGLUTAMASE

(Vibrio cholerae) 		PF00491
(Arginase) 		4 LEU A 255
ALA A  65
ASP A  53
ILE A  93
 None
 0.97A 4eyrA-1xfkA:
undetectable		 4eyrA-1xfkA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 LEU A  99
ASN A  96
VAL A  48
ILE A  22
 None
 0.88A 4eyrA-1xjeA:
undetectable		 4eyrA-1xjeA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Homo sapiens) 		PF00005
(ABC_tran)
PF14396
(CFTR_R) 		4 LEU A 570
ALA A 566
ASP A 565
VAL A 562
 None
 0.91A 4eyrA-1xmjA:
undetectable		 4eyrA-1xmjA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		5 LEU A  22
ALA A   7
VAL A  52
ILE A  39
THR A  21
 None
 1.27A 4eyrA-1xw8A:
undetectable		 4eyrA-1xw8A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE

(Salmonella
enterica) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 ALA A  43
VAL A  46
ILE A  58
THR A  30
 None
 0.77A 4eyrA-1yb4A:
undetectable		 4eyrA-1yb4A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YIAJ

(Escherichia
coli) 		PF01614
(IclR) 		4 LEU A  94
ASN A 124
ILE A  70
THR A  98
 None
 0.99A 4eyrA-1ysqA:
undetectable		 4eyrA-1ysqA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA

(Mycobacterium
tuberculosis) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 ASP A 399
VAL A 361
ILE A 349
THR A 356
 None
 0.79A 4eyrA-1zj9A:
undetectable		 4eyrA-1zj9A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzw DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00782
(DSPc) 		4 LEU A 358
ALA A 337
ILE A 325
THR A 355
 None
 0.99A 4eyrA-1zzwA:
undetectable		 4eyrA-1zzwA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aja ANKYRIN REPEAT
FAMILY PROTEIN

(Legionella
pneumophila) 		no annotation 4 LEU A 329
ASN A 331
ALA A 334
ILE A 306
 None
 0.92A 4eyrA-2ajaA:
undetectable		 4eyrA-2ajaA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8t THYMIDINE KINASE

(Ureaplasma
parvum) 		PF00265
(TK) 		4 ALA A 143
ASP A 144
ILE A  93
THR A  18
 None
 0.77A 4eyrA-2b8tA:
undetectable		 4eyrA-2b8tA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch9 CYSTATIN F

(Homo sapiens) 		PF00031
(Cystatin) 		4 LEU A  69
ASN A  61
ILE A  75
THR A  97
 None
 0.96A 4eyrA-2ch9A:
undetectable		 4eyrA-2ch9A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4v ISOCITRATE
DEHYDROGENASE

(Acidithiobacillus
thiooxidans) 		PF00180
(Iso_dh) 		4 LEU A 315
ALA A 295
ASP A 296
VAL A 322
 None
 0.99A 4eyrA-2d4vA:
undetectable		 4eyrA-2d4vA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dld D-LACTATE
DEHYDROGENASE

(Lactobacillus
helveticus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A  43
ALA A  47
ASP A  48
THR A  32
 None
 0.85A 4eyrA-2dldA:
undetectable		 4eyrA-2dldA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9y CARBAMATE KINASE

(Aeropyrum
pernix) 		PF00696
(AA_kinase) 		5 LEU A 223
ALA A 229
ASP A 230
VAL A 233
THR A  52
 None
 1.13A 4eyrA-2e9yA:
undetectable		 4eyrA-2e9yA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Aquifex
aeolicus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 141
ALA A 270
ILE A  76
THR A  81
 None
 0.97A 4eyrA-2ebdA:
undetectable		 4eyrA-2ebdA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efe SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana) 		PF00071
(Ras) 		4 ALA B 138
ASP B 137
VAL B  92
THR B 152
 None
 0.97A 4eyrA-2efeB:
undetectable		 4eyrA-2efeB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egg SHIKIMATE
5-DEHYDROGENASE

(Geobacillus
kaustophilus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ASN A 172
ALA A 178
VAL A 146
THR A 212
 None
 0.98A 4eyrA-2eggA:
undetectable		 4eyrA-2eggA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Aquifex
aeolicus) 		PF00290
(Trp_syntA) 		4 ALA A 228
ASP A 229
VAL A 232
ILE A 166
 None
 0.92A 4eyrA-2ekcA:
undetectable		 4eyrA-2ekcA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2euh NADP DEPENDENT NON
PHOSPHORYLATING
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Streptococcus
mutans) 		PF00171
(Aldedh) 		4 ALA A 175
VAL A  42
ILE A 238
THR A 207
 None
 0.94A 4eyrA-2euhA:
undetectable		 4eyrA-2euhA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 ALA A 373
ASP A 372
VAL A 363
ILE A 407
 None
 0.90A 4eyrA-2eyqA:
undetectable		 4eyrA-2eyqA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 LEU A 212
ALA A 192
VAL A  55
THR A 214
 None
None
None
FAD  A1000 (-4.2A)
 0.87A 4eyrA-2fjaA:
undetectable		 4eyrA-2fjaA:
8.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE

(Equine
infectious
anemia virus) 		PF00077
(RVP) 		4 LEU A  23
ALA A  28
ASP A  29
VAL A  32
 None
LP1  A 201 (-3.5A)
LP1  A 201 (-3.6A)
None
 0.27A 4eyrA-2fmbA:
13.9		 4eyrA-2fmbA:
30.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB

(Methanocaldococcus
jannaschii) 		PF02492
(cobW) 		4 ALA A 161
ASP A 162
VAL A 165
ILE A 119
 None
 0.62A 4eyrA-2hf8A:
undetectable		 4eyrA-2hf8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00288
(GHMP_kinases_N) 		4 LEU A 303
ALA A 289
VAL A 185
ILE A  17
 None
 0.97A 4eyrA-2hkeA:
undetectable		 4eyrA-2hkeA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i96 CYTOCHROME B5

(Homo sapiens) 		PF00173
(Cyt-b5) 		4 LEU A  71
ALA A  79
ASP A  78
THR A  46
 None
HEM  A 129 ( 3.1A)
None
None
 0.96A 4eyrA-2i96A:
undetectable		 4eyrA-2i96A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ig8 HYPOTHETICAL PROTEIN
PA3499

(Pseudomonas
aeruginosa) 		PF01042
(Ribonuc_L-PSP) 		4 LEU A  67
ALA A 130
VAL A  75
ILE A  94
 None
 0.96A 4eyrA-2ig8A:
undetectable		 4eyrA-2ig8A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n03 PLECTIN

(Homo sapiens) 		PF00681
(Plectin) 		4 LEU A4449
ALA A4472
ASP A4471
VAL A4483
 None
 0.90A 4eyrA-2n03A:
undetectable		 4eyrA-2n03A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 LEU A 238
ASN A 156
VAL A 135
ILE A 318
 None
 0.98A 4eyrA-2np0A:
undetectable		 4eyrA-2np0A:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 ALA A 289
VAL A 259
ILE A 314
THR A 283
 ALA  A 289 ( 0.0A)
VAL  A 259 ( 0.6A)
ILE  A 314 ( 0.4A)
THR  A 283 ( 0.8A)
 0.89A 4eyrA-2nvvA:
undetectable		 4eyrA-2nvvA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00275
(EPSP_synthase) 		4 ALA A 380
ASP A 383
ILE A 392
THR A   3
 None
 0.96A 4eyrA-2o0xA:
undetectable		 4eyrA-2o0xA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o57 PUTATIVE SARCOSINE
DIMETHYLGLYCINE
METHYLTRANSFERASE

(Galdieria
sulphuraria) 		PF08241
(Methyltransf_11) 		4 LEU A 130
ALA A  97
ASP A  88
ILE A  45
 None
 0.90A 4eyrA-2o57A:
undetectable		 4eyrA-2o57A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohw YUEI PROTEIN

(Bacillus
subtilis) 		PF07997
(DUF1694) 		4 LEU A  29
ALA A  39
ILE A 124
THR A 101
 None
 0.91A 4eyrA-2ohwA:
undetectable		 4eyrA-2ohwA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi2 MEVALONATE KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 LEU A 275
ALA A 167
ASP A 168
ILE A  15
 None
 0.95A 4eyrA-2oi2A:
undetectable		 4eyrA-2oi2A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozv HYPOTHETICAL PROTEIN
ATU0636

(Agrobacterium
fabrum) 		PF05175
(MTS) 		4 LEU A 119
ALA A  49
ILE A 177
THR A 163
 None
 0.92A 4eyrA-2ozvA:
undetectable		 4eyrA-2ozvA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1

(Pyrococcus
abyssi) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 LEU A 201
ALA A 219
VAL A 138
ILE A 167
 None
 0.95A 4eyrA-2pnzA:
undetectable		 4eyrA-2pnzA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt5 SHIKIMATE KINASE

(Aquifex
aeolicus) 		PF01202
(SKI) 		4 ALA A 140
ASP A 141
VAL A 144
ILE A  74
 None
 0.60A 4eyrA-2pt5A:
undetectable		 4eyrA-2pt5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		4 ASN A 393
ASP A 386
ILE A 208
THR A 370
 None
 0.98A 4eyrA-2pyxA:
undetectable		 4eyrA-2pyxA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzf CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Homo sapiens) 		PF00005
(ABC_tran) 		4 LEU A 570
ALA A 566
ASP A 565
VAL A 562
 None
 0.74A 4eyrA-2pzfA:
undetectable		 4eyrA-2pzfA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q74 INOSITOL-1-MONOPHOSP
HATASE

(Mycobacterium
tuberculosis) 		PF00459
(Inositol_P) 		5 LEU A 155
ASP A 214
VAL A 136
ILE A 116
THR A 143
 None
 1.39A 4eyrA-2q74A:
undetectable		 4eyrA-2q74A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Aromatoleum
aromaticum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 365
ALA A 306
VAL A 349
ILE A  31
 None
 0.92A 4eyrA-2qdeA:
undetectable		 4eyrA-2qdeA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7a BACTERIAL HEME
BINDING PROTEIN

(Shigella
dysenteriae) 		PF01497
(Peripla_BP_2) 		4 LEU A 167
ALA A 183
VAL A 218
THR A 220
 None
HEM  A 600 (-3.9A)
None
None
 0.87A 4eyrA-2r7aA:
undetectable		 4eyrA-2r7aA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 212
ASP A 216
VAL A 136
ILE A 195
 None
ANP  A1480 (-3.5A)
None
None
 0.90A 4eyrA-2v55A:
undetectable		 4eyrA-2v55A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc6 DIHYDRODIPICOLINATE
SYNTHASE

(Sinorhizobium
meliloti) 		PF00701
(DHDPS) 		4 ALA A 163
ASP A 162
ILE A 114
THR A  43
 MCL  A 161 ( 4.6A)
None
None
MCL  A 161 ( 4.6A)
 0.84A 4eyrA-2vc6A:
undetectable		 4eyrA-2vc6A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkn FORMAMIDASE

(Delftia
acidovorans) 		PF03069
(FmdA_AmdA) 		4 LEU A 306
ALA A 335
VAL A 358
THR A 379
 None
 0.98A 4eyrA-2wknA:
undetectable		 4eyrA-2wknA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)

(Archaeoglobus
fulgidus) 		PF02492
(cobW) 		4 ALA A 156
ASP A 157
VAL A 160
ILE A 114
 None
 0.66A 4eyrA-2wsmA:
undetectable		 4eyrA-2wsmA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsu PUTATIVE FIBER
PROTEIN

(Porcine
mastadenovirus
B) 		PF00337
(Gal-bind_lectin) 		4 LEU A 663
ALA A 591
ILE A 620
THR A 639
 None
 0.90A 4eyrA-2wsuA:
undetectable		 4eyrA-2wsuA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 ASN A 854
VAL A 851
ILE A 886
THR A 818
 None
 0.98A 4eyrA-2x05A:
undetectable		 4eyrA-2x05A:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		4 LEU A 504
ALA A 101
ASP A 103
VAL A  95
 None
 0.93A 4eyrA-2yevA:
undetectable		 4eyrA-2yevA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 260
ALA A 276
ASP A 273
ILE A 301
 None
 0.95A 4eyrA-2z63A:
undetectable		 4eyrA-2z63A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acz METHIONINE
GAMMA-LYASE

(Entamoeba
histolytica) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A 189
ALA A 196
ASP A 197
ILE A 102
 None
 0.72A 4eyrA-3aczA:
undetectable		 4eyrA-3aczA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		4 ALA A 404
VAL A 303
ILE A 389
THR A 358
 None
 0.83A 4eyrA-3afgA:
undetectable		 4eyrA-3afgA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aj6 MAIN HEMAGGLUTININ
COMPONENT

(Clostridium
botulinum) 		no annotation 5 LEU A 158
ASN A 278
ASP A 271
VAL A 268
THR A 156
 None
 1.38A 4eyrA-3aj6A:
undetectable		 4eyrA-3aj6A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1r RIBOKINASE, PUTATIVE

(Burkholderia
thailandensis) 		PF00294
(PfkB) 		4 LEU A 282
ALA A 254
ASP A 253
ILE A 218
 None
None
AMP  A 501 (-2.8A)
None
 0.96A 4eyrA-3b1rA:
undetectable		 4eyrA-3b1rA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2n UNCHARACTERIZED
PROTEIN Q99UF4

(Staphylococcus
aureus) 		PF00072
(Response_reg) 		4 ASP A 101
VAL A 104
ILE A   7
THR A  84
 None
 0.91A 4eyrA-3b2nA:
undetectable		 4eyrA-3b2nA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5q PUTATIVE SULFATASE
YIDJ

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 ASP A  24
VAL A 256
ILE A  20
THR A  41
 None
 0.96A 4eyrA-3b5qA:
undetectable		 4eyrA-3b5qA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE

(Methanocaldococcus
jannaschii) 		PF03587
(EMG1) 		4 LEU A 129
ALA A 135
VAL A 176
ILE A 183
 None
 0.90A 4eyrA-3bbhA:
undetectable		 4eyrA-3bbhA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I

(Bacillus
anthracis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ASN A 259
ALA A 263
VAL A 266
ILE A 299
 None
None
None
FAD  A 446 ( 4.0A)
 0.77A 4eyrA-3cgdA:
undetectable		 4eyrA-3cgdA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION

(Ruegeria
pomeroyi) 		no annotation 4 LEU A 194
ALA A 140
VAL A 163
THR A 197
 None
 0.92A 4eyrA-3cvoA:
undetectable		 4eyrA-3cvoA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N) 		4 LEU A 315
ALA A 301
VAL A 197
ILE A  21
 None
 0.95A 4eyrA-3d4jA:
undetectable		 4eyrA-3d4jA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6b GLUTARYL-COA
DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ALA A 176
ASP A 177
VAL A 107
ILE A  54
 None
 0.98A 4eyrA-3d6bA:
undetectable		 4eyrA-3d6bA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE

(Cytophaga
hutchinsonii) 		PF00682
(HMGL-like) 		4 ALA A 210
VAL A 244
ILE A 168
THR A 228
 None
 0.96A 4eyrA-3eegA:
undetectable		 4eyrA-3eegA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN

([Eubacterium]
rectale) 		PF13614
(AAA_31) 		5 LEU A 195
ASN A 192
ALA A 191
VAL A 106
ILE A  81
 None
 1.39A 4eyrA-3fkqA:
undetectable		 4eyrA-3fkqA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akm ORNITHINE
TRANSCARBAMYLASE

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ARG A 106
ALA A  65
ASP A  68
THR A 135
 None
 0.76A 4eyrB-1akmA:
undetectable		 4eyrB-1akmA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5l INTERFERON TAU

(Komagataella
pastoris) 		PF00143
(Interferon) 		4 ARG A  12
ASN A  14
GLY A  88
THR A 156
 SO4  A 201 (-2.8A)
None
None
None
 0.55A 4eyrB-1b5lA:
undetectable		 4eyrB-1b5lA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkg MOLECULAR CHAPERONE
DNAK

(Escherichia
coli) 		PF00012
(HSP70) 		4 GLY D 328
ALA D 327
ASP D 326
THR D 189
 None
 0.87A 4eyrB-1dkgD:
0.0		 4eyrB-1dkgD:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 GLY A 106
ALA A 107
ASP A 108
ASP A 138
 None
 0.54A 4eyrB-1e43A:
undetectable		 4eyrB-1e43A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 GLY A 268
ALA A 269
ASP A 247
THR A 262
 None
 0.88A 4eyrB-1edzA:
0.0		 4eyrB-1edzA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw8 PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		5 ARG A 110
ASN A  89
ALA A  91
ASP A 367
PRO A 335
 None
None
None
GOL  A 973 (-3.6A)
None
 1.47A 4eyrB-1fw8A:
undetectable		 4eyrB-1fw8A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 ASN A 176
GLY A 624
ALA A 625
THR A 281
 None
 0.86A 4eyrB-1g0dA:
0.0		 4eyrB-1g0dA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h14 ENDO-1,4-BETA-XYLANA
SE

(Pseudoalteromonas
haloplanktis) 		PF01270
(Glyco_hydro_8) 		5 ASN A  44
GLY A  42
ASP A  38
PRO A 374
THR A 375
 None
 1.33A 4eyrB-1h14A:
0.0		 4eyrB-1h14A:
13.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 ARG A   8
GLY A  27
ALA A  28
ASP A  29
ASP A  30
PRO A  81
 A79  A 800 (-3.4A)
A79  A 800 (-3.0A)
A79  A 800 (-3.1A)
A79  A 800 (-2.8A)
A79  A 800 ( 4.9A)
A79  A 800 ( 3.9A)
 0.89A 4eyrB-1hvcA:
12.5		 4eyrB-1hvcA:
43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 ARG A   8
GLY A  27
ALA A  28
ASP A  29
ASP A  30
PRO A  81
 A79  A 800 (-3.6A)
A79  A 800 (-3.0A)
A79  A 800 (-3.2A)
A79  A 800 (-2.7A)
A79  A 800 ( 4.7A)
A79  A 800 ( 3.4A)
 0.59A 4eyrB-1hvcA:
12.5		 4eyrB-1hvcA:
43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ARG A  87
GLY A  27
ALA A  28
ASP A  29
ASP A  30
 None
A79  A 800 (-3.0A)
A79  A 800 (-3.1A)
A79  A 800 (-2.8A)
A79  A 800 ( 4.9A)
 1.13A 4eyrB-1hvcA:
12.5		 4eyrB-1hvcA:
43.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 GLY A 247
ALA A 246
ASP A 242
PRO A 344
THR A 343
 None
 1.38A 4eyrB-1iq0A:
undetectable		 4eyrB-1iq0A:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js1 TRANSCARBAMYLASE

(Bacteroides
fragilis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 GLY X 229
ALA X 230
ASP X 231
THR X 202
 None
 0.47A 4eyrB-1js1X:
undetectable		 4eyrB-1js1X:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1d D-HYDANTOINASE

(Geobacillus
stearothermophilus) 		PF01979
(Amidohydro_1) 		4 GLY A 388
ASP A 390
ASP A 392
THR A  12
 None
 0.79A 4eyrB-1k1dA:
undetectable		 4eyrB-1k1dA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ll2 GLYCOGENIN-1

(Oryctolagus
cuniculus) 		PF01501
(Glyco_transf_8) 		5 GLY A  18
ALA A 103
ASP A 104
ASP A 102
THR A  39
 None
UPG  A 334 (-3.3A)
MN  A 333 ( 2.1A)
MN  A 333 ( 3.1A)
None
 1.28A 4eyrB-1ll2A:
undetectable		 4eyrB-1ll2A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4x PBCV-1 VIRUS CAPSID

(Paramecium
bursaria
Chlorella virus
1) 		PF04451
(Capsid_NCLDV)
PF16903
(Capsid_N) 		4 ASN A 280
GLY A 289
ALA A 288
ASP A 299
 None
 0.88A 4eyrB-1m4xA:
undetectable		 4eyrB-1m4xA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8p CYSTATHIONINE
GAMMA-LYASE

(Saccharomyces
cerevisiae) 		PF01053
(Cys_Met_Meta_PP) 		4 GLY A 193
ALA A 194
ASP A 195
THR A 146
 None
 0.74A 4eyrB-1n8pA:
undetectable		 4eyrB-1n8pA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfg D-HYDANTOINASE

(Ralstonia
pickettii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 GLY A 385
ASP A 387
ASP A 389
THR A  12
 None
 0.69A 4eyrB-1nfgA:
undetectable		 4eyrB-1nfgA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyt SHIKIMATE
5-DEHYDROGENASE

(Escherichia
coli) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ARG A 154
GLY A  83
ALA A  84
PRO A  63
 NAP  A1401 (-4.0A)
None
None
NAP  A1401 ( 4.7A)
 0.81A 4eyrB-1nytA:
undetectable		 4eyrB-1nytA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9b HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN YDIB

(Escherichia
coli) 		PF08501
(Shikimate_dh_N) 		4 ARG A 156
GLY A 134
ALA A 135
ASP A 107
 NAI  A 301 (-3.5A)
NAI  A 301 (-3.1A)
NAI  A 301 (-3.7A)
PO4  A 302 (-3.0A)
 0.76A 4eyrB-1o9bA:
undetectable		 4eyrB-1o9bA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9j ALDEHYDE
DEHYDROGENASE,
CYTOSOLIC 1

(Elephantulus
edwardii) 		PF00171
(Aldedh) 		5 GLY A 229
ALA A 228
ASP A  55
ASP A  58
PRO A 198
 NAD  A1501 (-3.5A)
None
None
None
None
 1.32A 4eyrB-1o9jA:
undetectable		 4eyrB-1o9jA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 GLY A 192
ALA A 193
PRO A 165
THR A 133
 None
None
None
GDP  A1318 ( 4.9A)
 0.73A 4eyrB-1ofuA:
undetectable		 4eyrB-1ofuA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh3 NON-CATALYTIC
PROTEIN 1

(Piromyces equi) 		no annotation 4 ARG A 124
GLY A  47
ALA A  48
ASP A 114
 None
 0.87A 4eyrB-1oh3A:
undetectable		 4eyrB-1oh3A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh9 ACETYLGLUTAMATE
KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		4 GLY A 173
ALA A 174
ASP A 175
PRO A 143
 None
 0.80A 4eyrB-1oh9A:
undetectable		 4eyrB-1oh9A:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q9p HIV-1 PROTEASE

(Homo sapiens) 		PF00077
(RVP) 		4 GLY A  27
ALA A  28
ASP A  29
ASP A  30
 None
 0.34A 4eyrB-1q9pA:
10.2		 4eyrB-1q9pA:
83.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)

(Rattus
norvegicus) 		PF00149
(Metallophos) 		4 ARG A  37
GLY A  43
ALA A  44
ASP A  45
 None
 0.83A 4eyrB-1qfcA:
undetectable		 4eyrB-1qfcA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3f TRNA PSEUDOURIDINE
SYNTHASE B

(Escherichia
coli) 		PF01509
(TruB_N)
PF09157
(TruB-C_2)
PF16198
(TruB_C_2) 		4 ASN A  37
GLY A   8
ASP A  10
PRO A 232
 None
 0.73A 4eyrB-1r3fA:
undetectable		 4eyrB-1r3fA:
16.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		6 ARG A   8
GLY A  27
ALA A  28
ASP A  29
ASP A  30
PRO A  81
 None
 0.59A 4eyrB-1sivA:
17.9		 4eyrB-1sivA:
47.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF06026
(Rib_5-P_isom_A) 		4 ARG A 213
GLY A  87
ALA A  88
ASP A  89
 None
 0.88A 4eyrB-1uj4A:
undetectable		 4eyrB-1uj4A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 218
ALA A 219
ASP A 220
THR A 205
 None
 0.88A 4eyrB-1uufA:
undetectable		 4eyrB-1uufA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb5 TRANSLATION
INITIATION FACTOR
EIF-2B

(Pyrococcus
horikoshii) 		PF01008
(IF-2B) 		4 GLY A 184
ALA A 185
ASP A 186
PRO A 271
 None
 0.85A 4eyrB-1vb5A:
undetectable		 4eyrB-1vb5A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY

(Thermotoga
maritima) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 ALA A 128
ASP A 129
ASP A 181
PRO A 211
 None
 0.81A 4eyrB-1vmaA:
undetectable		 4eyrB-1vmaA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xec DECORIN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 ASN A 238
ALA A 209
ASP A 208
ASP A 232
 None
 0.84A 4eyrB-1xecA:
undetectable		 4eyrB-1xecA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7n L(+)-MANDELATE
DEHYDROGENASE

(Pseudomonas
putida;
Spinacia
oleracea) 		PF01070
(FMN_dh) 		4 GLY A 246
ALA A 247
ASP A 248
THR A 157
 None
 0.87A 4eyrB-2a7nA:
undetectable		 4eyrB-2a7nA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN

(Streptococcus
pneumoniae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ASN A 316
GLY A 317
ALA A 318
ASP A 319
 None
 0.79A 4eyrB-2am2A:
undetectable		 4eyrB-2am2A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bws XAA-PRO
AMINOPEPTIDASE P

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 ARG A 221
GLY A 262
ALA A 261
ASP A 260
 None
None
None
MN  A1442 (-2.0A)
 0.83A 4eyrB-2bwsA:
undetectable		 4eyrB-2bwsA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		5 GLY A 487
ALA A 491
ASP A 493
PRO A 270
THR A 246
 None
 1.28A 4eyrB-2d4eA:
undetectable		 4eyrB-2d4eA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7u ADENYLOSUCCINATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00709
(Adenylsucc_synt) 		5 ARG A  55
GLY A 132
ALA A 134
ASP A 137
PRO A  78
 None
 1.47A 4eyrB-2d7uA:
undetectable		 4eyrB-2d7uA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF05694
(SBP56) 		4 ARG A 346
GLY A 365
ALA A 371
ASP A 372
 None
 0.80A 4eyrB-2eceA:
undetectable		 4eyrB-2eceA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eih ALCOHOL
DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 235
ALA A 236
ASP A 237
THR A 197
 None
 0.64A 4eyrB-2eihA:
undetectable		 4eyrB-2eihA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 ASN A 181
GLY A 184
ALA A 185
ASP A 186
 None
GOL  A2004 ( 4.4A)
None
None
 0.82A 4eyrB-2elcA:
undetectable		 4eyrB-2elcA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eng ENDOGLUCANASE V

(Humicola
insolens) 		PF02015
(Glyco_hydro_45) 		4 GLY A 128
ASP A 121
PRO A  61
THR A  60
 None
 0.87A 4eyrB-2engA:
undetectable		 4eyrB-2engA:
16.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE

(Equine
infectious
anemia virus) 		PF00077
(RVP) 		4 ARG A   8
GLY A  27
ALA A  28
ASP A  29
 LP1  A 201 (-3.5A)
LP1  A 201 (-3.8A)
LP1  A 201 (-3.5A)
LP1  A 201 (-3.6A)
 0.39A 4eyrB-2fmbA:
13.9		 4eyrB-2fmbA:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE

(Equine
infectious
anemia virus) 		PF00077
(RVP) 		4 GLY A  27
ALA A  28
ASP A  29
PRO A  86
 LP1  A 201 (-3.8A)
LP1  A 201 (-3.5A)
LP1  A 201 (-3.6A)
LP1  A 201 (-3.9A)
 0.41A 4eyrB-2fmbA:
13.9		 4eyrB-2fmbA:
30.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fq0 ACYL CARRIER PROTEIN

(Plasmodium
falciparum) 		PF00550
(PP-binding) 		4 GLY A  34
ALA A  35
ASP A  36
ASP A  39
 PNS  A 137 ( 3.2A)
None
PNS  A 137 (-2.3A)
None
 0.71A 4eyrB-2fq0A:
undetectable		 4eyrB-2fq0A:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuk XC6422 PROTEIN

(Xanthomonas
campestris) 		PF12146
(Hydrolase_4) 		4 GLY A 206
ALA A 207
PRO A 191
THR A 193
 None
 0.86A 4eyrB-2fukA:
undetectable		 4eyrB-2fukA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gr7 ADHESIN

(Haemophilus
influenzae) 		PF03895
(YadA_anchor) 		4 ASN A1083
GLY A1027
ALA A1026
ASP A1025
 None
 0.86A 4eyrB-2gr7A:
undetectable		 4eyrB-2gr7A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gr8 ADHESIN

(Haemophilus
influenzae) 		PF03895
(YadA_anchor) 		4 ASN A1083
GLY A1027
ALA A1026
ASP A1025
 None
 0.76A 4eyrB-2gr8A:
undetectable		 4eyrB-2gr8A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF13432
(TPR_16) 		5 ASN A 210
ALA A 185
ASP A 184
ASP A 188
PRO A 519
 None
 1.44A 4eyrB-2gw1A:
undetectable		 4eyrB-2gw1A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hev TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER 4

(Homo sapiens) 		PF00020
(TNFR_c6) 		4 ARG R  65
GLY R  70
ASP R 104
PRO R  80
 None
 0.87A 4eyrB-2hevR:
undetectable		 4eyrB-2hevR:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis) 		PF13419
(HAD_2) 		5 ARG A 103
ASP A   8
ASP A 171
PRO A 164
THR A 167
 None
 1.45A 4eyrB-2i6xA:
undetectable		 4eyrB-2i6xA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)

(Streptomyces
galilaeus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 GLY A 296
ALA A 297
PRO A 226
THR A 227
 None
 0.80A 4eyrB-2ipiA:
undetectable		 4eyrB-2ipiA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iss PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Thermotoga
maritima) 		PF01680
(SOR_SNZ) 		4 GLY A 129
ALA A 130
ASP A 132
PRO A 207
 None
 0.76A 4eyrB-2issA:
undetectable		 4eyrB-2issA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jnc CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
2

(Mus musculus) 		PF02793
(HRM) 		4 ARG A  47
GLY A  55
PRO A  72
THR A  62
 None
 0.78A 4eyrB-2jncA:
undetectable		 4eyrB-2jncA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lli PROTEIN AIR2

(Saccharomyces
cerevisiae) 		PF00098
(zf-CCHC) 		5 GLY A  29
ALA A  30
ASP A  33
ASP A  32
PRO A  21
 None
 1.38A 4eyrB-2lliA:
undetectable		 4eyrB-2lliA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mgv BIFUNCTIONAL
MEMBRANE-ASSOCIATED
PENICILLIN-BINDING
PROTEIN 1A/1B PONA2

(Mycobacterium
tuberculosis) 		PF03793
(PASTA) 		5 GLY A  23
ALA A  22
ASP A  21
PRO A  47
THR A  51
 None
 1.29A 4eyrB-2mgvA:
undetectable		 4eyrB-2mgvA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mt9 FLAVODOXIN-2

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		4 GLY A  94
ASP A  89
ASP A 145
THR A 121
 None
 0.71A 4eyrB-2mt9A:
undetectable		 4eyrB-2mt9A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE

(Homo sapiens) 		PF01053
(Cys_Met_Meta_PP) 		4 GLY A 202
ALA A 203
ASP A 204
THR A 158
 None
 0.47A 4eyrB-2nmpA:
undetectable		 4eyrB-2nmpA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o14 HYPOTHETICAL PROTEIN
YXIM

(Bacillus
subtilis) 		PF13472
(Lipase_GDSL_2) 		4 GLY A 269
ALA A 270
ASP A 271
THR A 161
 None
 0.83A 4eyrB-2o14A:
undetectable		 4eyrB-2o14A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocb RAS-RELATED PROTEIN
RAB-9B

(Homo sapiens) 		PF00071
(Ras) 		4 GLY A  79
ALA A  80
ASP A  81
THR A  63
 None
 0.75A 4eyrB-2ocbA:
undetectable		 4eyrB-2ocbA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 ARG A 186
ASN A 572
GLY A 194
ASP A 196
THR A 576
 None
 1.50A 4eyrB-2okjA:
undetectable		 4eyrB-2okjA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okk GLUTAMATE
DECARBOXYLASE 2

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 ARG A 177
ASN A 563
GLY A 185
ASP A 187
THR A 567
 None
 1.49A 4eyrB-2okkA:
undetectable		 4eyrB-2okkA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ory LIPASE

(Photobacterium
sp. M37) 		PF01764
(Lipase_3) 		4 GLY A 338
ALA A 337
ASP A 334
PRO A  94
 None
 0.76A 4eyrB-2oryA:
undetectable		 4eyrB-2oryA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osy ENDOGLYCOCERAMIDASE
II

(Rhodococcus sp.) 		PF00150
(Cellulase) 		4 GLY A 458
ALA A 459
ASP A 460
PRO A 433
 None
 0.81A 4eyrB-2osyA:
undetectable		 4eyrB-2osyA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph1 NUCLEOTIDE-BINDING
PROTEIN

(Archaeoglobus
fulgidus) 		PF10609
(ParA) 		4 ALA A  55
ASP A  56
ASP A 135
PRO A 153
 None
 0.84A 4eyrB-2ph1A:
undetectable		 4eyrB-2ph1A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjg PUTATIVE ALDOLASE
MJ0400

(Methanocaldococcus
jannaschii) 		PF01791
(DeoC) 		4 GLY A 112
ALA A 113
ASP A 114
THR A 103
 None
 0.86A 4eyrB-2qjgA:
undetectable		 4eyrB-2qjgA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r01 NITROREDUCTASE
FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF00881
(Nitroreductase) 		4 GLY A 108
ALA A 109
ASP A 112
THR A 153
 None
 0.76A 4eyrB-2r01A:
undetectable		 4eyrB-2r01A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbc SUGAR KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		4 ARG A 157
GLY A 177
PRO A 213
THR A 215
 None
 0.84A 4eyrB-2rbcA:
undetectable		 4eyrB-2rbcA:
15.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 ARG A   8
GLY A  27
ALA A  28
ASP A  29
ASP A  30
PRO A  81
 AB1  A 501 ( 4.7A)
AB1  A 501 (-3.9A)
AB1  A 501 (-3.5A)
AB1  A 501 ( 3.3A)
AB1  A 501 (-3.8A)
AB1  A 501 (-4.2A)
 0.41A 4eyrB-2rkfA:
18.9		 4eyrB-2rkfA:
81.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vea PHYTOCHROME-LIKE
PROTEIN CPH1

(Synechocystis
sp. PCC 6803) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 ARG A 165
GLY A 270
ALA A 271
ASP A 226
THR A 168
 None
 1.10A 4eyrB-2veaA:
undetectable		 4eyrB-2veaA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		4 GLY A 363
ASP A 365
ASP A 367
THR A  14
 None
 0.72A 4eyrB-2vhlA:
undetectable		 4eyrB-2vhlA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbp L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
vinaceus) 		PF02668
(TauD) 		4 GLY A 191
ASP A 302
ASP A 305
THR A 195
 None
 0.83A 4eyrB-2wbpA:
undetectable		 4eyrB-2wbpA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnx GLYCOSIDE HYDROLASE,
FAMILY 9

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		4 GLY A  89
ALA A  90
ASP A  91
THR A 147
 None
 0.78A 4eyrB-2wnxA:
undetectable		 4eyrB-2wnxA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wok CLAVULANIC ACID
BIOSYNTHESIS
OLIGOPEPTIDE BINDING
PROTEIN 2

(Streptomyces
clavuligerus) 		PF00496
(SBP_bac_5) 		5 ARG A 300
GLY A 454
ALA A 455
ASP A 456
THR A 355
 None
GOL  A1562 ( 3.6A)
None
None
None
 1.25A 4eyrB-2wokA:
undetectable		 4eyrB-2wokA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE

(Homo sapiens) 		PF00004
(AAA) 		4 GLY A 584
ALA A 585
ASP A 588
PRO A 623
 None
 0.66A 4eyrB-2x8aA:
undetectable		 4eyrB-2x8aA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymv ACG NITROREDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 5 GLY A 253
ALA A 252
ASP A 251
ASP A 248
THR A 274
 None
None
None
None
FNR  A1330 (-3.2A)
 1.44A 4eyrB-2ymvA:
undetectable		 4eyrB-2ymvA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymv ACG NITROREDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 5 GLY A 253
ALA A 252
ASP A 251
ASP A 248
THR A 277
 None
 1.36A 4eyrB-2ymvA:
undetectable		 4eyrB-2ymvA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzw ADP-RIBOSYLGLYCOHYDR
OLASE

(Thermus
thermophilus) 		PF03747
(ADP_ribosyl_GH) 		4 ARG A  11
GLY A 270
ALA A 271
ASP A 237
 None
 0.75A 4eyrB-2yzwA:
undetectable		 4eyrB-2yzwA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zki 199AA LONG
HYPOTHETICAL TRP
REPRESSOR BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF03358
(FMN_red) 		4 ARG A 186
GLY A  32
ALA A  33
PRO A 109
 None
 0.82A 4eyrB-2zkiA:
undetectable		 4eyrB-2zkiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aja PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		PF01083
(Cutinase) 		5 ARG A 250
GLY A 192
ASP A 197
ASP A 199
THR A 261
 None
 1.43A 4eyrB-3ajaA:
undetectable		 4eyrB-3ajaA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)

(Thermus
thermophilus) 		PF14520
(HHH_5)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb) 		4 GLY A 411
ALA A 412
ASP A 373
PRO A 425
 None
 0.86A 4eyrB-3auoA:
undetectable		 4eyrB-3auoA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 GLY A  72
ASP A  67
PRO A  94
THR A  88
 None
 0.72A 4eyrB-3cghA:
undetectable		 4eyrB-3cghA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clq UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF06545
(DUF1116) 		4 ALA A 135
ASP A 134
ASP A 131
PRO A 445
 None
 0.86A 4eyrB-3clqA:
undetectable		 4eyrB-3clqA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbg PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 GLY A 359
ALA A 360
ASP A 361
PRO A  24
 None
 0.54A 4eyrB-3dbgA:
undetectable		 4eyrB-3dbgA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc8 DIHYDROPYRIMIDINASE

(Sinorhizobium
meliloti) 		PF01979
(Amidohydro_1) 		5 GLY A 385
ALA A 386
ASP A 387
ASP A 389
THR A  12
 None
 1.06A 4eyrB-3dc8A:
undetectable		 4eyrB-3dc8A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dev SH1221

(Staphylococcus
haemolyticus) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 ARG A 267
GLY A 284
ALA A 279
ASP A 277
 SO4  A 322 (-4.3A)
None
None
None
 0.83A 4eyrB-3devA:
undetectable		 4eyrB-3devA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE

(Bacillus cereus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ARG A  89
GLY A  98
ALA A  99
PRO A  80
 None
 0.83A 4eyrB-3dhvA:
undetectable		 4eyrB-3dhvA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9d ZGC:56074

(Danio rerio) 		PF00300
(His_Phos_1) 		5 ARG A 238
GLY A 170
ALA A 171
ASP A 168
THR A   3
 None
 1.17A 4eyrB-3e9dA:
undetectable		 4eyrB-3e9dA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emo HIA (ADHESIN)

(Haemophilus
influenzae) 		no annotation 4 ASN C1083
GLY C1027
ALA C1026
ASP C1025
 None
 0.86A 4eyrB-3emoC:
undetectable		 4eyrB-3emoC:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		4 GLY A  87
ALA A  88
ASP A  89
THR A 225
 None
 0.80A 4eyrB-3g8mA:
undetectable		 4eyrB-3g8mA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goc ENDONUCLEASE V

(Streptomyces
avermitilis) 		PF04493
(Endonuclease_5) 		4 GLY A  38
ALA A  65
ASP A  64
PRO A 137
 None
 0.88A 4eyrB-3gocA:
undetectable		 4eyrB-3gocA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gt7 SENSOR PROTEIN

(Syntrophus
aciditrophicus) 		PF00072
(Response_reg) 		4 ARG A 102
GLY A 107
ALA A 108
ASP A 109
 None
 0.53A 4eyrB-3gt7A:
undetectable		 4eyrB-3gt7A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3y CARBOHYDRATE KINASE

(Klebsiella
pneumoniae) 		PF00294
(PfkB) 		4 ARG A  55
GLY A  40
ALA A  41
PRO A  77
 None
 0.86A 4eyrB-3i3yA:
undetectable		 4eyrB-3i3yA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwp COPPER HOMEOSTASIS
PROTEIN CUTC HOMOLOG

(Homo sapiens) 		PF03932
(CutC) 		4 GLY A 110
ALA A 111
ASP A 112
THR A  61
 None
 0.77A 4eyrB-3iwpA:
undetectable		 4eyrB-3iwpA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4s FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		4 ASN A  35
GLY A  29
ALA A  57
ASP A  75
 None
 0.77A 4eyrB-3j4sA:
undetectable		 4eyrB-3j4sA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzy INTERSECTIN 2

(Homo sapiens) 		PF00168
(C2) 		4 GLY A1560
ASP A1610
PRO A1650
THR A1651
 None
 0.71A 4eyrB-3jzyA:
undetectable		 4eyrB-3jzyA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2k PUTATIVE
CARBOXYPEPTIDASE

(Burkholderia
mallei) 		PF00246
(Peptidase_M14) 		5 ARG A 144
ASN A 228
GLY A 231
ALA A 232
THR A 140
 None
 1.38A 4eyrB-3k2kA:
undetectable		 4eyrB-3k2kA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg7 CURH

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		4 ARG A1191
GLY A1210
PRO A1143
THR A1142
 None
 0.76A 4eyrB-3kg7A:
undetectable		 4eyrB-3kg7A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A

(Streptococcus
mutans) 		PF06026
(Rib_5-P_isom_A) 		4 ARG A 209
GLY A  83
ALA A  84
ASP A  85
 None
 0.69A 4eyrB-3l7oA:
undetectable		 4eyrB-3l7oA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III

(Rhodopseudomonas
palustris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 GLY A 334
ALA A 333
PRO A  14
THR A  13
 None
 0.81A 4eyrB-3ledA:
undetectable		 4eyrB-3ledA:
13.87