SIMILAR PATTERNS OF AMINO ACIDS FOR 4EVR_A_BEZA401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6a HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN

(Homo sapiens) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		5 LEU A 138
VAL A 136
PHE A  12
PHE A 112
PHE A 145
 None
 1.50A 4evrA-1a6aA:
undetectable		 4evrA-1a6aA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amy 1,4-ALPHA-D-GLUCAN
GLUCANOHYDROLASE

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		5 LEU A  77
VAL A  26
PHE A 326
ALA A  32
PHE A   4
 None
 1.23A 4evrA-1amyA:
1.5		 4evrA-1amyA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b47 CBL

(Homo sapiens) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3) 		5 LEU A 230
TYR A 268
ALA A 262
PHE A 248
PHE A 244
 None
 1.08A 4evrA-1b47A:
0.1		 4evrA-1b47A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbv SIGNAL TRANSDUCTION
PROTEIN CBL

(Homo sapiens) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3)
PF14447
(Prok-RING_4) 		5 LEU A 230
TYR A 268
ALA A 262
PHE A 248
PHE A 244
 None
 1.08A 4evrA-1fbvA:
0.0		 4evrA-1fbvA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnf SEROTRANSFERRIN

(Oryctolagus
cuniculus) 		PF00405
(Transferrin) 		5 TYR A 514
VAL A 530
SER A 427
TYR A 425
ALA A 579
 CO3  A 701 ( 3.8A)
None
None
FE  A 703 ( 4.1A)
None
 1.19A 4evrA-1jnfA:
1.0		 4evrA-1jnfA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		5 LEU B 150
PHE B 222
ALA B 258
SER B 203
PHE B 191
 None
 1.42A 4evrA-1n94B:
undetectable		 4evrA-1n94B:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nf1 PROTEIN
(NEUROFIBROMIN)

(Homo sapiens) 		PF00616
(RasGAP) 		5 TYR A1296
LEU A1300
PHE A1389
PHE A1457
SER A1353
 None
 1.27A 4evrA-1nf1A:
0.1		 4evrA-1nf1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4o GLYCOLIPID
2-ALPHA-MANNOSYLTRAN
SFERASE

(Saccharomyces
cerevisiae) 		PF01793
(Glyco_transf_15) 		5 TYR A 344
LEU A 348
VAL A 364
SER A 366
SER A 291
 None
 1.36A 4evrA-1s4oA:
0.0		 4evrA-1s4oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv SEROTRANSFERRIN,
C-LOBE

(Homo sapiens) 		PF00405
(Transferrin) 		5 TYR E 514
VAL E 530
SER E 427
TYR E 425
ALA E 579
 CO3  E 701 ( 3.8A)
None
None
FE  E 703 ( 4.1A)
None
 1.19A 4evrA-1suvE:
1.4		 4evrA-1suvE:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmb ACETYLXYLAN ESTERASE
RELATED ENZYME

(Clostridium
acetobutylicum) 		PF03629
(SASA) 		5 LEU A 158
SER A 197
ASN A 178
PHE A 193
PHE A 216
 None
 1.44A 4evrA-1zmbA:
0.4		 4evrA-1zmbA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfr HYPOTHETICAL PROTEIN
AF1521

(Archaeoglobus
fulgidus) 		PF01661
(Macro) 		5 LEU A 124
VAL A 168
SER A 134
ALA A  26
PHE A  97
 None
 1.34A 4evrA-2bfrA:
4.6		 4evrA-2bfrA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ope PILX

(Neisseria
meningitidis) 		PF11530
(Pilin_PilX) 		5 TYR A  98
LEU A  66
VAL A  87
SER A  47
PHE A  69
 None
 1.47A 4evrA-2opeA:
undetectable		 4evrA-2opeA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Melanocarpus
albomyces) 		PF00840
(Glyco_hydro_7) 		5 LEU A 133
VAL A 131
PHE A 301
SER A 218
PHE A 223
 None
 1.34A 4evrA-2rfzA:
undetectable		 4evrA-2rfzA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 VAL A  49
TYR A  66
ALA A  35
SER A  70
PHE A  52
 None
 1.40A 4evrA-3a5kA:
2.8		 4evrA-3a5kA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djl PROTEIN AIDB

(Escherichia
coli) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 LEU A 439
VAL A 445
PHE A 377
ALA A 452
PHE A 453
 None
 1.48A 4evrA-3djlA:
undetectable		 4evrA-3djlA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 265
VAL A 255
ALA A 230
PHE A 222
SER A 269
 None
 1.31A 4evrA-3gdnA:
3.7		 4evrA-3gdnA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsi PHOSPHATIDYLSERINE
SYNTHASE

(Haemophilus
influenzae) 		PF13091
(PLDc_2) 		5 LEU A 246
VAL A 259
TYR A 371
PHE A  18
SER A 244
 None
 1.31A 4evrA-3hsiA:
undetectable		 4evrA-3hsiA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh8 MAOC-LIKE
DEHYDRATASE

(Phytophthora
capsici) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		5 LEU A  52
VAL A  96
PHE A 271
SER A 225
PHE A 288
 None
 1.46A 4evrA-3kh8A:
undetectable		 4evrA-3kh8A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
CALCINEURIN SUBUNIT
B TYPE 1

(Homo sapiens;
Homo sapiens) 		PF00149
(Metallophos)
PF13499
(EF-hand_7) 		5 LEU B 115
VAL B 114
ALA B  94
SER A 353
PHE A 350
 None
 1.39A 4evrA-3ll8B:
undetectable		 4evrA-3ll8B:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm3 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12979
(DUF3863)
PF12980
(DUF3864) 		5 LEU A 146
VAL A 151
TYR A 136
ALA A 158
SER A  65
 None
 1.13A 4evrA-3lm3A:
undetectable		 4evrA-3lm3A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nf4 ACYL-COA
DEHYDROGENASE

(Mycolicibacterium
thermoresistibile) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 174
VAL A 190
PHE A 199
ALA A 169
SER A 130
 None
 1.21A 4evrA-3nf4A:
undetectable		 4evrA-3nf4A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o38 SHORT CHAIN
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 LEU A  87
VAL A  84
SER A 131
ALA A 105
SER A  49
 None
 1.42A 4evrA-3o38A:
4.4		 4evrA-3o38A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odp PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Clostridium
novyi) 		PF01380
(SIS) 		5 LEU A 184
VAL A  75
SER A  77
ALA A 238
SER A 348
 None
 1.06A 4evrA-3odpA:
3.5		 4evrA-3odpA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 266
VAL A 256
ALA A 231
PHE A 222
SER A 270
 FAD  A 773 ( 4.6A)
None
None
None
None
 1.35A 4evrA-3redA:
3.0		 4evrA-3redA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sz6 CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF05031
(NEAT) 		5 VAL A  78
PHE A 114
ALA A  63
PHE A  42
PHE A 144
 None
 1.45A 4evrA-3sz6A:
undetectable		 4evrA-3sz6A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkr PEROXIREDOXIN-4

(Homo sapiens) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 LEU A 162
SER A  40
ALA A  42
PHE A 166
PHE A  78
 None
 1.07A 4evrA-3tkrA:
undetectable		 4evrA-3tkrA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 LEU A2511
VAL A2512
ALA A2519
PHE A2593
PHE A2596
 None
 1.44A 4evrA-3vkgA:
undetectable		 4evrA-3vkgA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		5 LEU A 743
VAL A 649
PHE A  99
SER A 236
PHE A 103
 None
None
DMU  A1776 (-4.5A)
None
None
 1.17A 4evrA-4a01A:
undetectable		 4evrA-4a01A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5g ANIONIC PEROXIDASE

(Raphanus
sativus) 		PF00141
(peroxidase) 		5 SER A 107
PHE A 277
PHE A 173
SER A 114
PHE A 230
 None
None
HEM  A1307 (-4.8A)
None
None
 1.44A 4evrA-4a5gA:
undetectable		 4evrA-4a5gA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccw CARBOXYL ESTERASE NP

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		5 VAL A 275
SER A 130
PHE A 182
ALA A  64
PHE A 201
 None
VKC  A1294 ( 3.8A)
VKC  A1294 (-4.5A)
VKC  A1294 (-3.4A)
None
 1.30A 4evrA-4ccwA:
3.2		 4evrA-4ccwA:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4evq PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		11 TYR A  46
LEU A  49
VAL A 107
SER A 109
ASN A 130
PHE A 150
TYR A 178
ALA A 180
PHE A 230
SER A 232
PHE A 257
 PHB  A 406 (-4.1A)
None
PHB  A 406 (-4.9A)
PHB  A 406 (-2.6A)
PHB  A 406 (-3.7A)
None
PHB  A 406 ( 4.3A)
PHB  A 406 (-3.2A)
PHB  A 406 (-4.8A)
PHB  A 406 (-2.7A)
PHB  A 406 (-3.8A)
 0.12A 4evrA-4evqA:
65.8		 4evrA-4evqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4evq PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		5 TYR A 178
SER A 232
PHE A 150
TYR A  46
SER A 109
 PHB  A 406 ( 4.3A)
PHB  A 406 (-2.7A)
None
PHB  A 406 (-4.1A)
PHB  A 406 (-2.6A)
 1.17A 4evrA-4evqA:
65.8		 4evrA-4evqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY

(Staphylococcus
aureus) 		PF00877
(NLPC_P60)
PF13702
(Lysozyme_like) 		5 LEU A 200
ASN A 194
TYR A 156
ALA A 161
PHE A 196
 None
 1.44A 4evrA-4fdyA:
undetectable		 4evrA-4fdyA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio cholerae) 		PF00496
(SBP_bac_5) 		5 LEU A 123
VAL A 130
PHE A  90
PHE A  67
PHE A 121
 None
 1.46A 4evrA-4gf8A:
undetectable		 4evrA-4gf8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwv SHORT CHAIN
ENOYL-COA HYDRATASE

(Novosphingobium
aromaticivorans) 		PF00378
(ECH_1) 		5 LEU A 185
VAL A 120
PHE A 127
ALA A 113
PHE A  61
 None
 1.31A 4evrA-4jwvA:
2.5		 4evrA-4jwvA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		5 LEU A 197
VAL A 181
PHE A 222
ALA A 253
PHE A 232
 None
 1.44A 4evrA-4p58A:
undetectable		 4evrA-4p58A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4j ABC TRANSPORTER

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 LEU A 162
VAL A 158
SER A 156
TYR A 275
ALA A 148
 None
 1.44A 4evrA-4q4jA:
undetectable		 4evrA-4q4jA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Dictyostelium
purpureum) 		PF05450
(Nicastrin) 		5 LEU A 527
ALA A 270
PHE A 222
SER A 220
PHE A 283
 None
 1.49A 4evrA-4r12A:
undetectable		 4evrA-4r12A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txw HYALURONOGLUCOSAMINI
DASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		5 TYR A  39
LEU A 149
PHE A 135
ALA A   6
PHE A  27
 None
 1.26A 4evrA-4txwA:
undetectable		 4evrA-4txwA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Pseudomonas
aeruginosa) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 TYR M 212
LEU M 204
VAL M 163
ALA M 216
PHE M 200
 None
 1.20A 4evrA-4wj3M:
undetectable		 4evrA-4wj3M:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgd NITRILE HYDRATASE
ALPHA SUBUNIT

(Comamonas
testosteroni) 		PF02979
(NHase_alpha) 		5 LEU A  62
VAL A  86
ALA A 106
PHE A  77
SER A  70
 None
 1.33A 4evrA-4zgdA:
undetectable		 4evrA-4zgdA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgd NITRILE HYDRATASE
ALPHA SUBUNIT

(Comamonas
testosteroni) 		PF02979
(NHase_alpha) 		5 LEU A  62
VAL A  86
ALA A 157
PHE A  77
SER A  70
 None
 1.22A 4evrA-4zgdA:
undetectable		 4evrA-4zgdA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axi E3 UBIQUITIN-PROTEIN
LIGASE CBL-B

(Mus musculus) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3) 		5 LEU A 222
TYR A 260
ALA A 254
PHE A 240
PHE A 236
 None
 0.97A 4evrA-5axiA:
undetectable		 4evrA-5axiA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 266
VAL A 256
ALA A 231
PHE A 222
SER A 270
 FAD  A 601 ( 4.7A)
None
None
None
None
 1.31A 4evrA-5eb5A:
2.7		 4evrA-5eb5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fx8 LINOLEATE
11-LIPOXYGENASE

(Gaeumannomyces
avenae) 		PF00305
(Lipoxygenase) 		5 LEU A 560
ASN A 564
ALA A 571
PHE A 411
PHE A 415
 None
 1.34A 4evrA-5fx8A:
undetectable		 4evrA-5fx8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3

(Saccharomyces
cerevisiae) 		PF13513
(HEAT_EZ) 		5 LEU A 223
VAL A 198
ALA A 238
PHE A 230
SER A 226
 None
 1.48A 4evrA-5h2vA:
undetectable		 4evrA-5h2vA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 LEU A 750
VAL A 774
TYR A 839
ALA A 826
PHE A 815
 None
 1.25A 4evrA-5h42A:
undetectable		 4evrA-5h42A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig5 CAMKII-B HUB

(Nematostella
vectensis) 		PF08332
(CaMKII_AD) 		5 TYR A 369
LEU A 357
VAL A 373
ASN A 464
ALA A 379
 None
 1.49A 4evrA-5ig5A:
undetectable		 4evrA-5ig5A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqo NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bacteroides
thetaiotaomicron) 		PF07944
(Glyco_hydro_127) 		5 LEU A 407
VAL A 331
TYR A 367
ALA A 293
PHE A 391
 None
 1.41A 4evrA-5mqoA:
undetectable		 4evrA-5mqoA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntf AMINOPEPTIDASE

(Trypanosoma
cruzi) 		PF00883
(Peptidase_M17) 		5 TYR A 350
LEU A 356
VAL A 366
PHE A 477
ALA A 371
 None
None
None
None
SO4  A 601 (-4.2A)
 1.35A 4evrA-5ntfA:
2.4		 4evrA-5ntfA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjj TRANSCRIPTIONAL
REGULATOR, ICLR
FAMILY

(Alicyclobacillus
acidocaldarius) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		5 LEU A 222
VAL A 130
PHE A 136
SER A 220
PHE A 143
 None
 1.31A 4evrA-5tjjA:
undetectable		 4evrA-5tjjA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vp3 MNEMIOPSIN 1

(Mnemiopsis
leidyi) 		no annotation 5 TYR A 131
LEU A 127
VAL A  81
PHE A  43
PHE A 155
 None
 1.44A 4evrA-5vp3A:
undetectable		 4evrA-5vp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG

(Homo sapiens) 		no annotation 5 LEU A  66
VAL A  70
SER A  31
ALA A  33
SER A  41
 None
 1.39A 4evrA-5wc2A:
undetectable		 4evrA-5wc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER

(Yersinia pestis) 		no annotation 5 TYR A 330
LEU A 334
SER A 339
TYR A 342
ALA A 257
 None
NA  A 401 ( 4.6A)
None
None
None
 1.30A 4evrA-6b2yA:
undetectable		 4evrA-6b2yA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6crj NORWALK VIRUS, MNV-1
CAPSID PROTEIN
CHIMERA

(Norwalk virus) 		no annotation 5 VAL B 391
PHE B 289
TYR B 295
ALA B 305
PHE B 355
 None
 1.40A 4evrA-6crjB:
undetectable		 4evrA-6crjB:
undetectable