SIMILAR PATTERNS OF AMINO ACIDS FOR 4EQ4_B_SALB601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2e ELONGATION FACTOR TU
(EF-TU)

(Bos taurus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 THR A 139
ILE A 106
THR A 430
GLY A 432
 None
 0.87A 4eq4B-1d2eA:
undetectable		 4eq4B-1d2eA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dt2 EXFOLIATIVE TOXIN B

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		4 LEU A 234
ILE A  55
VAL A  53
GLY A 199
 None
 0.71A 4eq4B-1dt2A:
undetectable		 4eq4B-1dt2A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 THR A 278
ILE A 296
VAL A 298
GLY A 313
 None
None
None
FAD  A 462 (-3.4A)
 0.79A 4eq4B-1ebdA:
undetectable		 4eq4B-1ebdA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g65 PROTEASOME COMPONENT
PUP3

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 LEU I 151
THR I   7
ILE I 110
VAL I 100
 None
 0.92A 4eq4B-1g65I:
undetectable		 4eq4B-1g65I:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1icp 12-OXOPHYTODIENOATE
REDUCTASE 1

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		4 TYR A 366
ILE A  96
VAL A 100
GLY A  66
 None
 0.84A 4eq4B-1icpA:
1.3		 4eq4B-1icpA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpu GLYCEROL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00465
(Fe-ADH) 		4 LEU A 265
ILE A 354
VAL A 350
GLY A 261
 None
 0.81A 4eq4B-1jpuA:
undetectable		 4eq4B-1jpuA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5o CPI-17

(Sus scrofa) 		PF05361
(PP1_inhibitor) 		4 ILE A  43
VAL A   3
THR A  67
GLY A  61
 None
 0.92A 4eq4B-1k5oA:
undetectable		 4eq4B-1k5oA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 LEU A 187
ILE A 389
VAL A 387
GLY A 466
 None
 0.92A 4eq4B-1mqqA:
0.0		 4eq4B-1mqqA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pfd FERREDOXIN

(Petroselinum
crispum) 		PF00111
(Fer2) 		4 THR A   9
VAL A  24
THR A  76
GLY A  49
 None
 0.87A 4eq4B-1pfdA:
undetectable		 4eq4B-1pfdA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 APOCYTOCHROME F

(Chlamydomonas
reinhardtii) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		4 LEU A 100
TYR A 102
ILE A  49
GLY A  72
 None
None
None
HEM  A 900 (-3.9A)
 0.93A 4eq4B-1q90A:
undetectable		 4eq4B-1q90A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxi MALATE DEHYDROGENASE

(Chloroflexus
aurantiacus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A  21
THR A 233
ILE A 116
VAL A 114
 None
 0.94A 4eq4B-1uxiA:
undetectable		 4eq4B-1uxiA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wm9 GTP CYCLOHYDROLASE I

(Thermus
thermophilus) 		PF01227
(GTP_cyclohydroI) 		4 LEU A 215
ILE A 121
VAL A 139
GLY A 101
 None
 0.88A 4eq4B-1wm9A:
undetectable		 4eq4B-1wm9A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3d MODULATOR OF DRUG
ACTIVITY B

(Escherichia
coli) 		PF02525
(Flavodoxin_2) 		4 LEU A 199
TYR A 195
ILE A  17
GLY A  41
 None
 0.78A 4eq4B-2b3dA:
2.0		 4eq4B-2b3dA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 THR A 229
ILE A  74
VAL A  78
GLY A 226
 None
 0.92A 4eq4B-2exrA:
undetectable		 4eq4B-2exrA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 LEU A 199
THR A 322
ILE A 159
VAL A 153
 None
 0.88A 4eq4B-2f43A:
undetectable		 4eq4B-2f43A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fy2 CHOLINE
O-ACETYLTRANSFERASE

(Homo sapiens) 		PF00755
(Carn_acyltransf) 		4 LEU A 172
ARG A 448
VAL A 331
GLY A 157
 None
 0.86A 4eq4B-2fy2A:
undetectable		 4eq4B-2fy2A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC

(Lactococcus
lactis) 		PF05147
(LANC_like) 		4 LEU A  39
TYR A  88
ILE A 329
GLY A 377
 None
 0.77A 4eq4B-2g02A:
undetectable		 4eq4B-2g02A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gl5 PUTATIVE DEHYDRATASE
PROTEIN

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 194
ILE A 223
VAL A 221
GLY A 202
 None
 0.86A 4eq4B-2gl5A:
undetectable		 4eq4B-2gl5A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB

(Methanocaldococcus
jannaschii) 		PF02492
(cobW) 		4 LEU A  28
THR A 135
ILE A 119
GLY A 103
 None
 0.69A 4eq4B-2hf8A:
1.7		 4eq4B-2hf8A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY

(Enterococcus
faecalis) 		PF04198
(Sugar-bind) 		4 THR A 134
ILE A 111
VAL A 113
GLY A 128
 None
 0.88A 4eq4B-2o0mA:
undetectable		 4eq4B-2o0mA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5z TYPE VI SECRETION
SYSTEM COMPONENT

(Escherichia
coli) 		PF05954
(Phage_GPD) 		4 LEU X 358
ILE X 326
VAL X 328
GLY X 313
 None
 0.76A 4eq4B-2p5zX:
undetectable		 4eq4B-2p5zX:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3x REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 1

(Rattus
norvegicus) 		PF00168
(C2) 		4 LEU A1571
ILE A1564
VAL A1544
GLY A1468
 None
 0.69A 4eq4B-2q3xA:
undetectable		 4eq4B-2q3xA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv0 PROTEIN MRKE

(Klebsiella
pneumoniae) 		PF00072
(Response_reg) 		4 LEU A 150
ILE A 107
VAL A  95
GLY A 118
 None
 0.85A 4eq4B-2qv0A:
2.7		 4eq4B-2qv0A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22)
PF01163
(RIO1) 		4 LEU A   6
ILE A  68
VAL A  63
GLY A  16
 None
 0.82A 4eq4B-2vwbA:
undetectable		 4eq4B-2vwbA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL

(Homo sapiens) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 THR A 369
ILE A 412
VAL A 414
GLY A 421
 None
 0.93A 4eq4B-2wd9A:
5.8		 4eq4B-2wd9A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zg6 PUTATIVE
UNCHARACTERIZED
PROTEIN ST2620

(Sulfurisphaera
tokodaii) 		PF13419
(HAD_2) 		4 LEU A  14
ARG A 193
VAL A 204
GLY A 171
 None
 0.92A 4eq4B-2zg6A:
undetectable		 4eq4B-2zg6A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvq NOTI RESTRICTION
ENDONUCLEASE

(Nocardia
otitidiscaviarum) 		PF12183
(NotI) 		4 THR A 114
ILE A 110
VAL A 134
GLY A 123
 None
 0.95A 4eq4B-3bvqA:
undetectable		 4eq4B-3bvqA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I

(Bacillus
anthracis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 THR A 248
ILE A 264
VAL A 266
GLY A 281
 None
None
None
FAD  A 446 (-3.3A)
 0.86A 4eq4B-3cgdA:
undetectable		 4eq4B-3cgdA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dci ARYLESTERASE

(Agrobacterium
fabrum) 		PF13472
(Lipase_GDSL_2) 		4 LEU A  37
ILE A  84
VAL A 131
GLY A 197
 None
 0.93A 4eq4B-3dciA:
undetectable		 4eq4B-3dciA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Thermoplasma
volcanium) 		PF01728
(FtsJ) 		4 LEU A  68
ILE A 130
VAL A 134
GLY A  46
 SAM  A   1 (-4.2A)
None
None
SAM  A   1 (-3.5A)
 0.91A 4eq4B-3douA:
undetectable		 4eq4B-3douA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Ruegeria
pomeroyi) 		PF13377
(Peripla_BP_3) 		4 THR A  86
ILE A 153
VAL A 151
GLY A 311
 None
 0.73A 4eq4B-3e3mA:
2.9		 4eq4B-3e3mA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01678
(DAP_epimerase) 		4 THR A 126
ILE A 131
VAL A 143
GLY A 102
 None
 0.83A 4eq4B-3ekmA:
undetectable		 4eq4B-3ekmA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eof PUTATIVE
OXIDOREDUCTASE

(Bacteroides
fragilis) 		PF00881
(Nitroreductase) 		4 THR A  75
ILE A 140
THR A 134
GLY A 131
 None
None
None
FMN  A 300 (-3.5A)
 0.67A 4eq4B-3eofA:
undetectable		 4eq4B-3eofA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f72 CADMIUM EFFLUX
SYSTEM ACCESSORY
PROTEIN

(Staphylococcus
aureus) 		PF01022
(HTH_5) 		4 LEU A  99
THR A  48
ILE A  39
GLY A  84
 None
 0.95A 4eq4B-3f72A:
undetectable		 4eq4B-3f72A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7n LIPASE

(Penicillium
expansum) 		PF01764
(Lipase_3) 		4 TYR A 204
ILE A 140
VAL A  99
GLY A 135
 None
 0.84A 4eq4B-3g7nA:
undetectable		 4eq4B-3g7nA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g87 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Burkholderia
pseudomallei) 		PF00698
(Acyl_transf_1) 		4 LEU A  99
TYR A 232
VAL A 249
GLY A  94
 None
 0.71A 4eq4B-3g87A:
undetectable		 4eq4B-3g87A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gde DNA LIGASE

(Archaeoglobus
fulgidus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 LEU A  70
TYR A 144
ILE A 159
GLY A  64
 None
 0.88A 4eq4B-3gdeA:
undetectable		 4eq4B-3gdeA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  42
ILE A  10
VAL A  86
GLY A  52
 None
 0.80A 4eq4B-3i6eA:
undetectable		 4eq4B-3i6eA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  40
ILE A   8
VAL A  84
GLY A  50
 None
 0.90A 4eq4B-3i6tA:
2.1		 4eq4B-3i6tA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ita D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC

(Escherichia
coli) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 LEU A 236
THR A 157
VAL A  26
GLY A  30
 None
 0.88A 4eq4B-3itaA:
undetectable		 4eq4B-3itaA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Desulfovibrio
vulgaris) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 THR A 259
ILE A 275
VAL A 277
GLY A 292
 None
 0.89A 4eq4B-3iwaA:
undetectable		 4eq4B-3iwaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg0 ORNITHINE
AMINOTRANSFERASE

(Plasmodium
falciparum) 		PF00202
(Aminotran_3) 		4 LEU A 389
THR A 386
VAL A 202
GLY A 347
 None
 0.86A 4eq4B-3lg0A:
undetectable		 4eq4B-3lg0A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		4 LEU A 321
THR A 229
ILE A 329
GLY A 326
 None
 0.85A 4eq4B-3lpdA:
undetectable		 4eq4B-3lpdA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcp GLUCOKINASE

(Parabacteroides
distasonis) 		PF00480
(ROK) 		4 LEU A 242
ILE A 263
VAL A 340
GLY A 247
 None
 0.67A 4eq4B-3mcpA:
undetectable		 4eq4B-3mcpA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpg DIHYDROOROTASE

(Bacillus
anthracis) 		PF01979
(Amidohydro_1) 		4 THR A 373
VAL A 117
THR A  87
GLY A  54
 None
 0.94A 4eq4B-3mpgA:
0.9		 4eq4B-3mpgA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0v FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Pseudomonas
putida) 		PF00551
(Formyl_trans_N) 		4 LEU A 168
ILE A 235
VAL A 284
GLY A 268
 None
 0.79A 4eq4B-3n0vA:
undetectable		 4eq4B-3n0vA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oox PUTATIVE 2OG-FE(II)
OXYGENASE FAMILY
PROTEIN

(Caulobacter
vibrioides) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 LEU A 226
ILE A  47
VAL A  51
GLY A 201
 None
None
None
EDO  A 321 ( 4.3A)
 0.76A 4eq4B-3ooxA:
undetectable		 4eq4B-3ooxA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT
PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF02912
(Phe_tRNA-synt_N)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 LEU B 574
VAL A 173
THR A 129
GLY A 191
 None
 0.86A 4eq4B-3pcoB:
undetectable		 4eq4B-3pcoB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sd7 PUTATIVE PHOSPHATASE

(Clostridioides
difficile) 		PF13419
(HAD_2) 		4 LEU A  16
ILE A 211
VAL A 205
GLY A 167
 None
 0.89A 4eq4B-3sd7A:
undetectable		 4eq4B-3sd7A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		4 LEU A 321
THR A 229
ILE A 329
GLY A 326
 None
 0.83A 4eq4B-3ti7A:
undetectable		 4eq4B-3ti7A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uhj PROBABLE GLYCEROL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00465
(Fe-ADH) 		4 LEU A 287
ILE A 376
VAL A 372
GLY A 283
 None
 0.89A 4eq4B-3uhjA:
undetectable		 4eq4B-3uhjA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Streptomyces
avermitilis) 		PF00215
(OMPdecase) 		4 THR A  82
ILE A  24
VAL A  22
GLY A  55
 None
 0.72A 4eq4B-3v75A:
undetectable		 4eq4B-3v75A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3won DIPEPTIDYL
AMINOPEPTIDASE BII

(Pseudoxanthomonas
mexicana) 		PF10459
(Peptidase_S46) 		4 ARG A 220
VAL A 696
THR A 222
GLY A 207
 VAL  A 801 (-4.5A)
None
None
None
 0.63A 4eq4B-3wonA:
undetectable		 4eq4B-3wonA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zre THIOL PEROXIDASE

(Yersinia
pseudotuberculosis) 		PF08534
(Redoxin) 		4 THR A 131
ILE A  52
VAL A 136
GLY A 119
 None
 0.84A 4eq4B-3zreA:
undetectable		 4eq4B-3zreA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE

(Thermotoga
maritima) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		4 LEU A  64
ILE A  81
THR A  11
GLY A  22
 None
 0.75A 4eq4B-4a2bA:
undetectable		 4eq4B-4a2bA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2

(Homo sapiens) 		PF00753
(Lactamase_B) 		4 LEU A  59
ILE A  73
VAL A  75
GLY A  48
 None
 0.95A 4eq4B-4ad9A:
undetectable		 4eq4B-4ad9A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2

(Homo sapiens) 		PF00753
(Lactamase_B) 		4 LEU A  59
ILE A  73
VAL A  75
GLY A  85
 None
 0.89A 4eq4B-4ad9A:
undetectable		 4eq4B-4ad9A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg0 POLYPROTEIN

(Saint Louis
encephalitis
virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		4 LEU A  23
THR A   6
ILE A 297
VAL A 295
 None
 0.90A 4eq4B-4fg0A:
undetectable		 4eq4B-4fg0A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhi MTN13 PROTEIN

(Medicago
truncatula) 		PF00407
(Bet_v_1) 		4 LEU A  90
TYR A 133
ILE A  98
GLY A  87
 None
EMU  A 202 ( 4.3A)
EMU  A 202 ( 4.9A)
None
 0.94A 4eq4B-4jhiA:
undetectable		 4eq4B-4jhiA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo6 STREPTAVIDIN

(Streptomyces
avidinii) 		PF01382
(Avidin) 		4 THR A  71
ILE A  17
VAL A  31
GLY A  74
 None
 0.81A 4eq4B-4jo6A:
undetectable		 4eq4B-4jo6A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4koa 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 THR A  71
ILE A   7
VAL A  59
GLY A  78
 NDP  A 500 (-4.6A)
None
None
None
 0.95A 4eq4B-4koaA:
undetectable		 4eq4B-4koaA:
19.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l39 4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12

(Arabidopsis
thaliana) 		PF03321
(GH3) 		8 LEU A 116
TYR A 120
ARG A 123
THR A 161
ILE A 217
VAL A 299
THR A 324
GLY A 326
 SAL  A 602 (-4.7A)
SAL  A 602 (-4.3A)
SAL  A 602 (-3.1A)
None
SAL  A 602 ( 4.4A)
APC  A 603 (-4.2A)
SAL  A 602 ( 3.7A)
SAL  A 602 ( 3.6A)
 0.33A 4eq4B-4l39A:
63.2		 4eq4B-4l39A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5n URACIL-DNA
GLYCOSYLASE

(Human
alphaherpesvirus
1) 		PF03167
(UDG) 		4 LEU A 187
ILE A 173
VAL A 169
GLY A  86
 None
ACT  A 304 ( 4.5A)
None
None
 0.90A 4eq4B-4l5nA:
undetectable		 4eq4B-4l5nA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 4 THR A 266
ILE A 178
VAL A 187
GLY A 181
 None
None
None
F6P  A 701 (-3.6A)
 0.94A 4eq4B-4lc9A:
3.3		 4eq4B-4lc9A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mca GLYCEROL
DEHYDROGENASE

(Serratia
plymuthica) 		PF00465
(Fe-ADH) 		4 LEU A 263
ILE A 352
VAL A 348
GLY A 259
 None
 0.83A 4eq4B-4mcaA:
undetectable		 4eq4B-4mcaA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mea PREDICTED PROTEIN

(Acinetobacter
nosocomialis) 		PF00561
(Abhydrolase_1) 		4 LEU A 167
TYR A 154
ILE A 114
GLY A 141
 None
 0.82A 4eq4B-4meaA:
undetectable		 4eq4B-4meaA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o87 N-TAGGED NUCLEASE

(Millerozyma
acaciae) 		no annotation 4 LEU A 200
ILE A 268
THR A 183
GLY A 180
 None
 0.78A 4eq4B-4o87A:
undetectable		 4eq4B-4o87A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovm UNCHARACTERIZED
PROTEIN SGCJ

(Streptomyces
carzinostaticus) 		PF14534
(DUF4440) 		4 TYR A 136
ILE A 118
THR A 100
GLY A  83
 None
 0.75A 4eq4B-4ovmA:
undetectable		 4eq4B-4ovmA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oyy CUTINASE

(Humicola
insolens) 		PF01083
(Cutinase) 		4 LEU A  22
ILE A 111
VAL A 115
GLY A 128
 None
 0.85A 4eq4B-4oyyA:
undetectable		 4eq4B-4oyyA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN

(Legionella
pneumophila) 		PF13855
(LRR_8) 		4 LEU A 250
ILE A 228
VAL A 201
GLY A 222
 SO4  A 504 (-4.5A)
None
None
None
 0.89A 4eq4B-4q62A:
undetectable		 4eq4B-4q62A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u02 AMINO ACID ABC
TRANSPORTER,
ATP-BINDING PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran) 		4 LEU A 242
ILE A  36
VAL A  34
GLY A 199
 None
 0.95A 4eq4B-4u02A:
undetectable		 4eq4B-4u02A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjp MONOSACCHARIDE-TRANS
PORTING ATPASE

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		4 THR A 269
ILE A 283
VAL A 285
GLY A 263
 None
 0.84A 4eq4B-4zjpA:
2.9		 4eq4B-4zjpA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8w CGMP-DEPENDENT
PROTEIN KINASE 2

(Homo sapiens) 		PF00027
(cNMP_binding) 		4 THR A 229
ILE A 225
VAL A 215
GLY A 232
 None
None
PCG  A 302 (-4.7A)
PCG  A 302 (-3.6A)
 0.92A 4eq4B-5c8wA:
undetectable		 4eq4B-5c8wA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9e SEPL

(Escherichia
coli) 		PF07201
(HrpJ) 		4 LEU A 167
ILE A 100
THR A  95
GLY A 172
 None
 0.77A 4eq4B-5c9eA:
undetectable		 4eq4B-5c9eA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm3 L-GLUTAMINE
SYNTHETASE

(Chromohalobacter
salexigens) 		PF00120
(Gln-synt_C) 		4 ARG A 190
THR A 179
THR A 203
GLY A 205
 None
 0.85A 4eq4B-5dm3A:
undetectable		 4eq4B-5dm3A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC

(Bacillus
subtilis) 		PF00698
(Acyl_transf_1) 		4 LEU A  94
TYR A 229
VAL A 246
GLY A  89
 None
 0.74A 4eq4B-5dz6A:
undetectable		 4eq4B-5dz6A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE

(Bacillus
subtilis) 		PF00698
(Acyl_transf_1) 		4 LEU A  94
TYR A 229
VAL A 246
GLY A  89
 None
 0.67A 4eq4B-5dz7A:
undetectable		 4eq4B-5dz7A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4r KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 TYR A 366
ILE A 282
VAL A 278
GLY A 194
 None
 0.86A 4eq4B-5e4rA:
2.1		 4eq4B-5e4rA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyg CYTOCHROME P450

(Marinobacter
hydrocarbonoclasticus) 		PF00067
(p450) 		4 LEU A 435
ILE A 446
VAL A 448
GLY A 323
 None
 0.86A 4eq4B-5fygA:
undetectable		 4eq4B-5fygA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		4 TYR A 182
ILE A 198
VAL A 234
GLY A 124
 None
 0.76A 4eq4B-5gsmA:
undetectable		 4eq4B-5gsmA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hoe HYDROLASE

(Sinorhizobium
meliloti) 		PF13472
(Lipase_GDSL_2) 		4 LEU A  44
ILE A  90
VAL A 139
GLY A 207
 None
 0.84A 4eq4B-5hoeA:
undetectable		 4eq4B-5hoeA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL

(Coccidioides
posadasii) 		PF00579
(tRNA-synt_1b) 		4 LEU A 330
THR A 328
VAL A 117
GLY A 127
 None
None
TYR  A 501 ( 4.0A)
None
 0.83A 4eq4B-5ijxA:
undetectable		 4eq4B-5ijxA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Flavobacterium
psychrophilum) 		PF10459
(Peptidase_S46) 		4 ARG A 215
VAL A 683
THR A 217
GLY A 202
 None
 0.73A 4eq4B-5jxfA:
undetectable		 4eq4B-5jxfA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyv LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ARG A 218
ILE A 351
VAL A 366
GLY A 341
 SLU  A 601 ( 4.2A)
None
None
SLU  A 601 (-4.0A)
 0.94A 4eq4B-5kyvA:
9.8		 4eq4B-5kyvA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL

(Bos taurus) 		PF00329
(Complex1_30kDa) 		4 LEU C  61
TYR C  94
ILE C 117
GLY C  56
 None
 0.75A 4eq4B-5lc5C:
undetectable		 4eq4B-5lc5C:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH

(Eremococcus
coleocola) 		PF01566
(Nramp) 		4 ARG A 369
THR A 350
ILE A 122
THR A 372
 None
 0.79A 4eq4B-5m8jA:
undetectable		 4eq4B-5m8jA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7z LIPOPOLYSACCHARIDE
1,6-GALACTOSYLTRANSF
ERASE

(Salmonella
enterica) 		no annotation 4 LEU A 122
ILE A 158
VAL A 160
GLY A 143
 None
 0.78A 4eq4B-5n7zA:
undetectable		 4eq4B-5n7zA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ook PHYCOCYANIN, ALPHA
SUBUNIT
PHYCOCYANIN, BETA
SUBUNIT

(Acaryochloris
marina) 		no annotation 4 THR B   6
ILE A   6
VAL A   9
GLY B 102
 None
 0.85A 4eq4B-5ookB:
undetectable		 4eq4B-5ookB:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot0 L-ASPARAGINASE

(Thermococcus
kodakarensis) 		no annotation 4 THR A   8
ILE A  81
VAL A 106
GLY A  66
 None
 0.90A 4eq4B-5ot0A:
1.3		 4eq4B-5ot0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sga PROTEINASE A (SGPA)

(Streptomyces
griseus) 		PF00089
(Trypsin) 		4 LEU E 235
ILE E 124
VAL E 118
GLY E 211
 None
 0.90A 4eq4B-5sgaE:
undetectable		 4eq4B-5sgaE:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t33 RHPA GP120 CORE

(Human
immunodeficiency
virus) 		PF00516
(GP120) 		4 TYR G 484
ARG G 273
VAL G 270
GLY G 451
 None
 0.80A 4eq4B-5t33G:
undetectable		 4eq4B-5t33G:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE

(Sinorhizobium
meliloti) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A 112
ILE A 198
VAL A 228
GLY A 106
 None
 0.81A 4eq4B-5v72A:
2.6		 4eq4B-5v72A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w75 ELONGATION FACTOR TU

(Thermotoga
neapolitana) 		no annotation 4 THR A  94
ILE A  61
THR A 383
GLY A 385
 None
 0.85A 4eq4B-5w75A:
1.8		 4eq4B-5w75A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w76 ANCESTRAL ELOGATION
FACTOR N153

(synthetic
construct) 		no annotation 4 THR A  94
ILE A  61
THR A 383
GLY A 385
 None
 0.92A 4eq4B-5w76A:
1.5		 4eq4B-5w76A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE

(unidentified) 		PF00465
(Fe-ADH) 		4 LEU A 263
ILE A 352
VAL A 348
GLY A 259
 None
 0.86A 4eq4B-5xn8A:
undetectable		 4eq4B-5xn8A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1

(Desulfovibrio
vulgaris;
Homo sapiens) 		PF00001
(7tm_1)
PF00258
(Flavodoxin_1) 		4 LEU A 286
THR A 201
ILE A 247
GLY A 281
 None
 0.72A 4eq4B-5xraA:
undetectable		 4eq4B-5xraA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z95 -

(-) 		no annotation 4 ARG A 176
THR A  56
VAL A  32
GLY A  27
 None
 0.89A 4eq4B-5z95A:
undetectable		 4eq4B-5z95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15) 		no annotation 4 THR A 832
ILE A 717
VAL A 719
GLY A 825
 None
 0.82A 4eq4B-6bfuA:
undetectable		 4eq4B-6bfuA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk5 UBIQUITIN LIGASE CBL

(Salpingoeca
rosetta) 		no annotation 4 LEU A 317
THR A 290
THR A 298
GLY A 287
 None
 0.92A 4eq4B-6bk5A:
undetectable		 4eq4B-6bk5A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA

(Chromobacterium
violaceum) 		no annotation 4 LEU B 402
ILE B 191
VAL B 195
GLY B  16
 None
 0.90A 4eq4B-6esdB:
undetectable		 4eq4B-6esdB:
8.64