SIMILAR PATTERNS OF AMINO ACIDS FOR 4EOH_A_TEPA402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4i METHYLENETETRAHYDROF
OLATE DEHYDROGENASE
/
METHENYLTETRAHYDROFO
LATE CYCLOHYDROLASE

(Homo sapiens) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 SER A 174
GLY A 172
THR A 148
VAL A 213
 NDP  A 302 (-2.6A)
NDP  A 302 (-3.5A)
NDP  A 302 (-3.6A)
None
 0.92A 4eohA-1a4iA:
4.1		 4eohA-1a4iA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvn PROTEIN
(TENDAMISTAT)

(Streptomyces
tendae) 		PF01356
(A_amylase_inhib) 		4 SER T 863
GLY T 862
THR T 841
ASP T 858
 None
 1.14A 4eohA-1bvnT:
undetectable		 4eohA-1bvnT:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlk THROMBIN HEAVY CHAIN

(Bos taurus) 		PF00089
(Trypsin) 		4 SER B 223
GLY B 187
THR B 219
VAL B  17
 None
 1.11A 4eohA-1dlkB:
undetectable		 4eohA-1dlkB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drk D-RIBOSE-BINDING
PROTEIN

(Escherichia
coli) 		PF13407
(Peripla_BP_4) 		4 SER A 136
THR A  87
VAL A  71
ASP A  69
 None
 1.12A 4eohA-1drkA:
2.6		 4eohA-1drkA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		4 SER M  62
GLY M  63
VAL M 471
ASP M  65
 None
 1.14A 4eohA-1dwaM:
undetectable		 4eohA-1dwaM:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h9h TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		4 SER E 195
GLY E  43
THR E 229
VAL E  53
 None
 1.12A 4eohA-1h9hE:
undetectable		 4eohA-1h9hE:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ll2 GLYCOGENIN-1

(Oryctolagus
cuniculus) 		PF01501
(Glyco_transf_8) 		4 SER A 134
GLY A 135
THR A  83
ASP A 102
 UPG  A 334 (-3.2A)
UPG  A 334 ( 4.1A)
None
MN  A 333 ( 3.1A)
 1.04A 4eohA-1ll2A:
undetectable		 4eohA-1ll2A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 SER A1185
GLY A 574
THR A1083
VAL A1049
 None
None
MTE  A3003 (-4.5A)
None
 1.15A 4eohA-1n5xA:
2.5		 4eohA-1n5xA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1

(Pinus taeda) 		PF05368
(NmrA) 		4 SER A 223
GLY A 183
THR A 277
ASP A 182
 None
 1.14A 4eohA-1qycA:
5.3		 4eohA-1qycA:
23.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rfv PYRIDOXAL KINASE

(Ovis aries) 		PF08543
(Phos_pyr_kin) 		5 SER A  12
GLY A  20
THR A  47
VAL A 231
ASP A 235
 None
 0.69A 4eohA-1rfvA:
48.0		 4eohA-1rfvA:
86.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4f RNA-DEPENDENT RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		4 SER A 343
GLY A 450
THR A 500
ASP A 449
 None
 1.10A 4eohA-1s4fA:
undetectable		 4eohA-1s4fA:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1td2 PYRIDOXAMINE KINASE

(Escherichia
coli) 		PF08543
(Phos_pyr_kin) 		4 GLY A  18
THR A  45
VAL A 220
ASP A 224
 PXL  A 288 ( 4.1A)
PXL  A 288 (-2.7A)
PXL  A 288 (-4.5A)
PXL  A 288 (-2.5A)
 0.44A 4eohA-1td2A:
36.8		 4eohA-1td2A:
32.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1td2 PYRIDOXAMINE KINASE

(Escherichia
coli) 		PF08543
(Phos_pyr_kin) 		4 SER A  10
THR A  45
VAL A 220
ASP A 224
 PXL  A 288 (-2.4A)
PXL  A 288 (-2.7A)
PXL  A 288 (-4.5A)
PXL  A 288 (-2.5A)
 0.78A 4eohA-1td2A:
36.8		 4eohA-1td2A:
32.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ul7 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Mus musculus) 		PF02149
(KA1) 		4 GLY A  54
THR A  85
VAL A  60
ASP A  53
 None
 1.12A 4eohA-1ul7A:
undetectable		 4eohA-1ul7A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxr MANNOSE-BINDING
LECTIN

(Morus nigra) 		PF01419
(Jacalin) 		4 SER A  34
GLY A  33
THR A  13
ASP A  31
 None
 1.14A 4eohA-1xxrA:
undetectable		 4eohA-1xxrA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7n L(+)-MANDELATE
DEHYDROGENASE

(Pseudomonas
putida;
Spinacia
oleracea) 		PF01070
(FMN_dh) 		4 SER A 291
GLY A 290
VAL A   8
ASP A 332
 None
 1.11A 4eohA-2a7nA:
undetectable		 4eohA-2a7nA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1c ISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		4 GLY A  27
THR A  73
VAL A  60
ASP A  28
 None
 1.05A 4eohA-2d1cA:
undetectable		 4eohA-2d1cA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 SER A  91
GLY A  88
THR A 212
ASP A  86
 None
None
FAD  A1001 ( 4.2A)
None
 1.10A 4eohA-2ebaA:
undetectable		 4eohA-2ebaA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frv PERIPLASMIC
HYDROGENASE

(Desulfovibrio
gigas) 		no annotation 4 SER L  37
GLY L 491
THR L  40
VAL L 535
 None
 1.02A 4eohA-2frvL:
undetectable		 4eohA-2frvL:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		4 SER A 733
GLY A 732
THR A 825
ASP A 659
 None
 0.91A 4eohA-2g28A:
undetectable		 4eohA-2g28A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozv HYPOTHETICAL PROTEIN
ATU0636

(Agrobacterium
fabrum) 		PF05175
(MTS) 		4 GLY A  52
THR A 163
VAL A 127
ASP A  50
 None
 1.11A 4eohA-2ozvA:
4.4		 4eohA-2ozvA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdl CHYMASE 2

(Mesocricetus
auratus) 		PF00089
(Trypsin) 		4 SER A 152
GLY A 142
VAL A 139
ASP A 194
 None
 1.10A 4eohA-2rdlA:
undetectable		 4eohA-2rdlA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 SER A 248
GLY A 281
VAL A 276
ASP A 278
 None
 0.98A 4eohA-2xtlA:
2.6		 4eohA-2xtlA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynk WZI

(Escherichia
coli) 		PF14052
(Caps_assemb_Wzi) 		4 SER A 439
GLY A 440
VAL A 446
ASP A 441
 None
 1.15A 4eohA-2ynkA:
undetectable		 4eohA-2ynkA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Thermus
thermophilus) 		PF00753
(Lactamase_B) 		4 GLY A 189
THR A  38
VAL A  22
ASP A 190
 None
None
None
ZN  A 319 ( 2.4A)
 0.94A 4eohA-2zo4A:
undetectable		 4eohA-2zo4A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak4 NADH-DEPENDENT
QUINUCLIDINONE
REDUCTASE

(Agrobacterium
tumefaciens) 		PF13561
(adh_short_C2) 		4 GLY A  16
THR A  65
VAL A  62
ASP A  40
 NAD  A 901 (-3.6A)
NAD  A 901 ( 4.3A)
NAD  A 901 (-4.8A)
NAD  A 901 (-2.8A)
 1.02A 4eohA-3ak4A:
6.4		 4eohA-3ak4A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwx ALPHA/BETA HYDROLASE

(Novosphingobium
aromaticivorans) 		PF12697
(Abhydrolase_6) 		4 SER A 237
GLY A 234
THR A 244
VAL A 231
 None
 1.10A 4eohA-3bwxA:
5.9		 4eohA-3bwxA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 SER A 935
GLY A 955
VAL A 910
ASP A 954
 None
 1.12A 4eohA-3f2bA:
undetectable		 4eohA-3f2bA:
15.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fhx PYRIDOXAL KINASE

(Homo sapiens) 		PF08543
(Phos_pyr_kin) 		4 SER A  12
GLY A  20
THR A  47
VAL A 231
 PXL  A 313 (-3.3A)
None
PXL  A 313 (-2.7A)
SO4  A 314 ( 4.0A)
 0.18A 4eohA-3fhxA:
51.8		 4eohA-3fhxA:
99.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foa TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N) 		4 SER A 108
GLY A 138
THR A 105
ASP A 135
 None
 1.13A 4eohA-3foaA:
4.1		 4eohA-3foaA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2n TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		4 SER U 108
GLY U 138
THR U 105
ASP U 135
 None
 1.13A 4eohA-3j2nU:
4.6		 4eohA-3j2nU:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j70 MONOCLONAL ANTIBODY
17B LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER A 203
GLY A 118
THR A 151
VAL A 142
 None
 0.92A 4eohA-3j70A:
undetectable		 4eohA-3j70A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njp EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 SER A 423
GLY A 425
THR A 450
VAL A 500
 None
 1.05A 4eohA-3njpA:
undetectable		 4eohA-3njpA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		4 SER A 276
GLY A 278
VAL A 283
ASP A 281
 None
 1.04A 4eohA-3o8lA:
3.3		 4eohA-3o8lA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxx CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 GLY A  14
THR A 131
VAL A  74
ASP A  37
 None
None
None
NAD  A 284 (-2.8A)
 1.15A 4eohA-3pxxA:
6.5		 4eohA-3pxxA:
19.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pzs PYRIDOXAMINE KINASE

(Yersinia pestis) 		PF08543
(Phos_pyr_kin) 		5 SER A   9
GLY A  17
THR A  44
VAL A 219
ASP A 223
 None
None
None
SO4  A 288 (-3.6A)
SO4  A 288 (-3.4A)
 0.39A 4eohA-3pzsA:
40.4		 4eohA-3pzsA:
31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 SER C1185
GLY C 574
THR C1083
VAL C1049
 None
 1.12A 4eohA-3sr6C:
undetectable		 4eohA-3sr6C:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swo GLUTARYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 SER A 103
GLY A 100
THR A 222
ASP A  98
 EDO  A 503 ( 4.0A)
None
FDA  A 500 ( 3.9A)
None
 1.09A 4eohA-3swoA:
undetectable		 4eohA-3swoA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Bos taurus) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase) 		4 SER A 350
GLY A 701
THR A 357
ASP A 706
 None
None
None
MG  A1005 ( 4.7A)
 1.14A 4eohA-3tlmA:
undetectable		 4eohA-3tlmA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14

(Pyrococcus
furiosus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 GLY A 184
THR A  66
VAL A  78
ASP A 181
 None
 1.08A 4eohA-3tm5A:
3.5		 4eohA-3tm5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tos CALS11

(Micromonospora
echinospora) 		PF05711
(TylF) 		4 GLY A  77
THR A 196
VAL A 167
ASP A 107
 SAH  A 258 (-3.4A)
None
SAH  A 258 (-3.6A)
SAH  A 258 (-2.7A)
 1.14A 4eohA-3tosA:
5.2		 4eohA-3tosA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 GLY A 201
THR A 494
VAL A 208
ASP A 205
 None
 1.10A 4eohA-4arxA:
2.8		 4eohA-4arxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4u BIFUNCTIONAL PROTEIN
FOLD

(Acinetobacter
baumannii) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 SER A 167
GLY A 165
THR A 141
VAL A 206
 NAP  A1001 (-4.5A)
NAP  A1001 (-3.6A)
None
None
 1.04A 4eohA-4b4uA:
4.2		 4eohA-4b4uA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE

(Trypanosoma
brucei) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 SER A 211
GLY A 378
THR A 366
VAL A 334
 None
 1.12A 4eohA-4bi9A:
undetectable		 4eohA-4bi9A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e79 UDP-3-O-ACYLGLUCOSAM
INE
N-ACYLTRANSFERASE

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF04613
(LpxD)
PF14602
(Hexapep_2) 		4 SER A 118
GLY A 136
THR A 103
VAL A 140
 None
 1.13A 4eohA-4e79A:
undetectable		 4eohA-4e79A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn4 SHORT CHAIN
DEHYDROGENASE

(Sulfolobus
acidocaldarius) 		PF13561
(adh_short_C2) 		4 SER A 203
GLY A  98
THR A 209
ASP A  97
 None
 0.98A 4eohA-4fn4A:
6.4		 4eohA-4fn4A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13306
(LRR_5) 		4 SER A 305
GLY A 304
THR A 312
VAL A 301
 EDO  A 502 (-4.9A)
None
None
None
 1.08A 4eohA-4fs7A:
undetectable		 4eohA-4fs7A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gys ALLOPHANATE
HYDROLASE

(Granulibacter
bethesdensis) 		PF01425
(Amidase) 		4 SER A 234
GLY A 190
THR A 100
VAL A 207
 None
 0.98A 4eohA-4gysA:
undetectable		 4eohA-4gysA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnl MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Enterococcus
gallinarum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A  33
GLY A  34
VAL A 315
ASP A  99
 None
 1.13A 4eohA-4hnlA:
undetectable		 4eohA-4hnlA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6k AMIDOHYDROLASE
FAMILY PROTEIN

(Acinetobacter
baumannii) 		PF04909
(Amidohydro_2) 		4 SER A 190
GLY A 224
VAL A  49
ASP A   7
 None
 1.11A 4eohA-4i6kA:
undetectable		 4eohA-4i6kA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kp2 HOMOACONITASE LARGE
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		4 SER A 301
GLY A 305
THR A 122
ASP A 309
 None
 0.95A 4eohA-4kp2A:
undetectable		 4eohA-4kp2A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ml9 UNCHARACTERIZED
PROTEIN

(Sebaldella
termitidis) 		PF00977
(His_biosynth) 		4 SER A  31
GLY A 258
VAL A 264
ASP A 262
 None
GOL  A 307 (-3.6A)
None
EDO  A 310 (-3.6A)
 1.12A 4eohA-4ml9A:
2.7		 4eohA-4ml9A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mln PREDICTED HD
PHOSPHOHYDROLASE
PHNZ

(uncultured
bacterium
HF130_AEPn_1) 		PF01966
(HD) 		4 SER A 123
THR A 129
VAL A 105
ASP A 161
 ODV  A 203 ( 4.9A)
ODV  A 203 (-3.3A)
ODV  A 203 ( 4.6A)
FE  A 201 (-2.4A)
 1.13A 4eohA-4mlnA:
undetectable		 4eohA-4mlnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01425
(Amidase) 		4 SER A 216
GLY A 172
THR A  79
VAL A 189
 None
 0.89A 4eohA-4n0iA:
undetectable		 4eohA-4n0iA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6w PREDICTED HD
PHOSPHOHYDROLASE
PHNZ

(uncultured
bacterium
HF130_AEPn_1) 		PF01966
(HD) 		4 SER A 123
THR A 129
VAL A 105
ASP A 161
 FLC  A 203 ( 4.5A)
FLC  A 203 (-3.2A)
None
FE  A 202 ( 2.5A)
 0.96A 4eohA-4n6wA:
undetectable		 4eohA-4n6wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN

(Cupriavidus
taiwanensis) 		PF13561
(adh_short_C2) 		4 GLY A  12
THR A  64
VAL A  61
ASP A  36
 None
 1.14A 4eohA-4nbvA:
6.9		 4eohA-4nbvA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqy ISOPROPYLMALATE/CITR
AMALATE ISOMERASE
LARGE SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		4 SER A 303
GLY A 307
THR A 127
ASP A 311
 None
 1.01A 4eohA-4nqyA:
undetectable		 4eohA-4nqyA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 SER A  80
GLY A  82
THR A1218
VAL A1196
 None
 1.04A 4eohA-4o9xA:
undetectable		 4eohA-4o9xA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ops MAJOR CAPSID PROTEIN

(Norwalk virus) 		PF08435
(Calici_coat_C) 		4 GLY A 354
THR A 323
VAL A 351
ASP A 355
 None
 0.97A 4eohA-4opsA:
undetectable		 4eohA-4opsA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oyy CUTINASE

(Humicola
insolens) 		PF01083
(Cutinase) 		4 SER A 105
GLY A 133
THR A  37
ASP A 160
 None
 1.00A 4eohA-4oyyA:
2.2		 4eohA-4oyyA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzv 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE/DI
HYDROPTEROATE
SYNTHASE

(Francisella
tularensis) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		4 GLY A 347
THR A 215
VAL A 278
ASP A 345
 None
EDO  A 503 (-3.7A)
None
None
 0.68A 4eohA-4pzvA:
undetectable		 4eohA-4pzvA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4quk DIHYDROFLAVONOL-4-RE
DUCTASE

(Medicago
truncatula) 		PF01370
(Epimerase) 		4 GLY A  71
THR A  13
VAL A  76
ASP A  74
 None
 0.88A 4eohA-4qukA:
3.0		 4eohA-4qukA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII

(Loxosceles
intermedia) 		no annotation 4 SER A 167
GLY A 168
THR A  95
ASP A 170
 IPD  A 304 (-3.9A)
None
None
GOL  A 305 (-3.8A)
 1.14A 4eohA-4rw3A:
undetectable		 4eohA-4rw3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Yersinia
enterocolitica) 		PF01380
(SIS) 		4 SER A 209
GLY A 211
THR A  87
VAL A 219
 None
 1.10A 4eohA-4s12A:
2.8		 4eohA-4s12A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1i PYRIDOXAL KINASE

(Entamoeba
histolytica) 		PF08543
(Phos_pyr_kin) 		4 SER B  10
GLY B  18
THR B  45
ASP B 218
 PLP  B 302 (-2.4A)
PLP  B 302 ( 4.4A)
PLP  B 302 (-3.2A)
PLP  B 302 (-3.5A)
 0.72A 4eohA-4s1iB:
34.2		 4eohA-4s1iB:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
HB3VAR03 CIDRA
DOMAIN

(Homo sapiens;
Plasmodium
falciparum) 		PF03011
(PFEMP)
PF16497
(MHC_I_3) 		4 SER A 653
GLY B  78
THR B  46
VAL B  25
 None
 1.05A 4eohA-4v3dA:
undetectable		 4eohA-4v3dA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 GLY A 201
THR A 494
VAL A 208
ASP A 205
 None
 1.07A 4eohA-4w8jA:
2.9		 4eohA-4w8jA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		4 GLY A  14
THR A  66
VAL A  63
ASP A  38
 None
 1.06A 4eohA-4weoA:
4.3		 4eohA-4weoA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 SER A 446
GLY A 449
VAL A 576
ASP A 578
 None
 0.94A 4eohA-4wjlA:
undetectable		 4eohA-4wjlA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		no annotation 4 SER E 504
GLY E 503
THR E 489
ASP E 502
 None
 1.13A 4eohA-4xmmE:
undetectable		 4eohA-4xmmE:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF00497
(SBP_bac_3) 		4 SER A 202
GLY A 104
THR A  85
ASP A 177
 None
None
EDO  A 403 ( 4.9A)
GSH  A 401 (-3.0A)
 1.09A 4eohA-4z9nA:
undetectable		 4eohA-4z9nA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 SER B 216
GLY B 387
THR B 308
VAL B 347
 None
 0.87A 4eohA-5a8rB:
undetectable		 4eohA-5a8rB:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b6a PYRIDOXAL KINASE
PDXY

(Pseudomonas
aeruginosa) 		PF08543
(Phos_pyr_kin) 		5 SER A  12
GLY A  20
THR A  47
VAL A 221
ASP A 225
 TRS  A 301 (-3.1A)
TRS  A 301 ( 4.5A)
TRS  A 301 (-3.0A)
None
MG  A 302 (-3.0A)
 0.31A 4eohA-5b6aA:
39.0		 4eohA-5b6aA:
31.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1

(Chaetomium
thermophilum) 		PF00400
(WD40) 		4 SER B 790
GLY B 792
VAL B 770
ASP B 794
 None
 1.05A 4eohA-5cxcB:
undetectable		 4eohA-5cxcB:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6o HOMOSERINE
O-ACETYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF00561
(Abhydrolase_1) 		4 SER A 220
GLY A 324
VAL A 331
ASP A 321
 None
 1.14A 4eohA-5d6oA:
2.1		 4eohA-5d6oA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdn PHOSPHOENOLPYRUVATE
CARBOXYLASE 3

(Arabidopsis
thaliana) 		PF00311
(PEPcase) 		4 GLY A 527
THR A 633
VAL A 559
ASP A 450
 None
 1.13A 4eohA-5fdnA:
undetectable		 4eohA-5fdnA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		4 SER A  86
GLY A  85
VAL A   2
ASP A  44
 None
 1.00A 4eohA-5ffnA:
5.8		 4eohA-5ffnA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqm PROTEIN UPS1,
MITOCHONDRIAL,MITOCH
ONDRIAL DISTRIBUTION
AND MORPHOLOGY
PROTEIN 35

(Saccharomyces
cerevisiae) 		PF04707
(PRELI)
PF05254
(UPF0203) 		4 GLY A  48
THR A  90
VAL A  83
ASP A  45
 None
 1.14A 4eohA-5jqmA:
undetectable		 4eohA-5jqmA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1

(Escherichia
coli) 		PF00884
(Sulfatase) 		4 GLY A 372
THR A 451
VAL A 377
ASP A 375
 None
 1.03A 4eohA-5k4pA:
undetectable		 4eohA-5k4pA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kia L-THREONINE
3-DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 SER A 240
GLY A 171
VAL A 215
ASP A 195
 None
 1.01A 4eohA-5kiaA:
undetectable		 4eohA-5kiaA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 2

(Sus scrofa) 		no annotation 4 SER A 350
GLY A 701
THR A 357
ASP A 706
 None
None
None
MGF  A1001 ( 4.0A)
 1.12A 4eohA-5mpmA:
undetectable		 4eohA-5mpmA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mx9 PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-2

(Escherichia
coli) 		PF00884
(Sulfatase) 		4 GLY A 372
THR A 451
VAL A 377
ASP A 375
 None
 1.06A 4eohA-5mx9A:
undetectable		 4eohA-5mx9A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8p S-LAYER PROTEIN

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		4 SER A 850
GLY A 872
THR A 854
ASP A 878
 None
CA  A9014 ( 4.9A)
None
CA  A9014 (-3.4A)
 1.07A 4eohA-5n8pA:
undetectable		 4eohA-5n8pA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n97 S-LAYER PROTEIN RSAA

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		4 SER A 850
GLY A 872
THR A 854
ASP A 878
 None
CA  A9014 ( 4.9A)
None
CA  A9014 (-3.4A)
 1.08A 4eohA-5n97A:
undetectable		 4eohA-5n97A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nm7 PEPTIDOGLYCAN-BINDIN
G DOMAIN 1

(Burkholderia) 		no annotation 4 SER G 165
GLY G 169
THR G 176
VAL G 196
 None
 1.10A 4eohA-5nm7G:
undetectable		 4eohA-5nm7G:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3z SORBITOL-6-PHOSPHATE
DEHYDROGENASE

(Erwinia
amylovora) 		no annotation 4 GLY A   9
THR A  63
VAL A  60
ASP A  33
 None
 1.00A 4eohA-5o3zA:
5.3		 4eohA-5o3zA:
15.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tqi PYRIDOXAL KINASE
PDXY

(Burkholderia
multivorans) 		PF08543
(Phos_pyr_kin) 		4 SER A   9
GLY A  17
VAL A 217
ASP A 221
 None
 0.66A 4eohA-5tqiA:
37.6		 4eohA-5tqiA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5trw PYRIDOXAL KINASE
PDXY

(Paraburkholderia
xenovorans) 		PF08543
(Phos_pyr_kin) 		4 GLY A  18
THR A  45
VAL A 218
ASP A 222
 None
 0.40A 4eohA-5trwA:
37.8		 4eohA-5trwA:
34.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5trw PYRIDOXAL KINASE
PDXY

(Paraburkholderia
xenovorans) 		PF08543
(Phos_pyr_kin) 		4 SER A  10
THR A  45
VAL A 218
ASP A 222
 None
 0.72A 4eohA-5trwA:
37.8		 4eohA-5trwA:
34.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA

(Human
immunodeficiency
virus 1;
Sulfolobus
solfataricus) 		PF00552
(IN_DBD_C)
PF00665
(rve)
PF02022
(Integrase_Zn) 		4 SER A 119
GLY A 118
THR A  97
ASP A 116
 None
None
None
MG  A 501 (-2.8A)
 1.07A 4eohA-5u1cA:
undetectable		 4eohA-5u1cA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 SER A 700
GLY A 701
THR A 625
VAL A 483
 None
None
None
AGS  A2001 (-4.9A)
 1.08A 4eohA-5v8fA:
undetectable		 4eohA-5v8fA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vis DIHYDROPTEROATE
SYNTHASE

(soil metagenome) 		PF00809
(Pterin_bind) 		4 GLY A 179
THR A 139
VAL A 107
ASP A 177
 None
 1.09A 4eohA-5visA:
undetectable		 4eohA-5visA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xau LAMININ SUBUNIT
ALPHA-5

(Homo sapiens) 		PF02210
(Laminin_G_2)
PF06009
(Laminin_II) 		4 SER A3086
GLY A2948
VAL A3111
ASP A2947
 None
 0.95A 4eohA-5xauA:
undetectable		 4eohA-5xauA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgt SINGLE-STRANDED
DNA-BINDING PROTEIN

(Staphylococcus
aureus) 		PF00436
(SSB) 		4 SER A  25
THR A  28
VAL A  61
ASP A  59
 None
 1.06A 4eohA-5xgtA:
undetectable		 4eohA-5xgtA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN

(Escherichia
coli) 		no annotation 4 GLY A 370
THR A 449
VAL A 375
ASP A 373
 None
 1.07A 4eohA-5xnuA:
undetectable		 4eohA-5xnuA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 4 SER A 343
GLY A 450
THR A 500
ASP A 449
 None
 1.07A 4eohA-5y6rA:
undetectable		 4eohA-5y6rA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5f NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia
enterocolitica) 		no annotation 4 SER A 290
GLY A 263
THR A 179
ASP A 262
 None
None
SO4  A 401 (-2.8A)
None
 0.95A 4eohA-6b5fA:
undetectable		 4eohA-6b5fA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqw BACTERIAL ACTIN ALFA

(Bacillus
subtilis) 		no annotation 4 SER A 171
GLY A 170
THR A  77
ASP A 168
 ANP  A 301 (-2.5A)
ANP  A 301 (-3.1A)
None
ANP  A 301 ( 3.8A)
 1.09A 4eohA-6bqwA:
undetectable		 4eohA-6bqwA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9y SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Paraburkholderia
phymatum) 		no annotation 4 GLY A  15
THR A  66
VAL A  63
ASP A  39
 None
 0.96A 4eohA-6d9yA:
5.1		 4eohA-6d9yA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))

(Escherichia
coli) 		no annotation 4 SER A 243
GLY A 177
THR A 251
ASP A 201
 None
 1.12A 4eohA-6dkhA:
4.7		 4eohA-6dkhA:
19.15