SIMILAR PATTERNS OF AMINO ACIDS FOR 4ENH_A_FVXA602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clx XYLANASE A

(Cellvibrio
japonicus) 		PF00331
(Glyco_hydro_10) 		5 LEU A  65
ILE A  45
ALA A  13
ALA A  21
ALA A  16
 None
 0.78A 4enhA-1clxA:
0.0		 4enhA-1clxA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE

(Oryza sativa) 		PF00834
(Ribul_P_3_epim) 		5 LEU A  82
ILE A  55
ILE A  39
THR A  91
ALA A  87
 None
 1.01A 4enhA-1h1yA:
0.0		 4enhA-1h1yA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0d ENDODEOXYRIBONUCLEAS
E I

(Escherichia
virus T7) 		PF05367
(Phage_endo_I) 		5 LEU A  58
ILE A  62
ILE A 130
ALA A 127
ALA A 121
 None
 1.12A 4enhA-1m0dA:
undetectable		 4enhA-1m0dA:
14.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n97 CYP175A1

(Thermus
thermophilus) 		PF00067
(p450) 		5 ALA A 221
THR A 225
ALA A 268
TRP A 269
THR A 372
 HEM  A 602 (-3.3A)
HEM  A 602 (-3.8A)
HEM  A 602 ( 4.0A)
EDO  A 715 ( 4.4A)
None
 0.92A 4enhA-1n97A:
40.2		 4enhA-1n97A:
31.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ECDYSONE RECEPTOR

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		5 LEU D 439
ILE D 298
ALA D 299
GLY D 307
ALA D 438
 None
 0.71A 4enhA-1r20D:
undetectable		 4enhA-1r20D:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli) 		PF00294
(PfkB) 		5 LEU A 305
ILE A 301
ALA A 274
GLY A 254
ALA A 280
 None
None
None
ADP  A 310 (-3.3A)
None
 0.91A 4enhA-1rk2A:
0.0		 4enhA-1rk2A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus) 		PF00348
(polyprenyl_synt) 		5 LEU A 315
ALA A 305
ALA A 186
GLY A 190
ALA A  53
 None
 1.16A 4enhA-1wmwA:
0.1		 4enhA-1wmwA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LEU A 476
ILE A 479
ILE A 555
THR A 531
ALA A 473
 None
 0.99A 4enhA-1xpgA:
0.0		 4enhA-1xpgA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zef ALKALINE PHOSPHATASE

(Homo sapiens) 		PF00245
(Alk_phosphatase) 		5 LEU A  69
ALA A  51
THR A  48
ALA A 327
THR A 331
 None
 1.12A 4enhA-1zefA:
undetectable		 4enhA-1zefA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 LEU A 188
ILE A 201
ALA A 168
ALA A 176
THR A 175
 None
 1.08A 4enhA-1zfjA:
undetectable		 4enhA-1zfjA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2can ORNITHINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00202
(Aminotran_3) 		5 LEU A 402
ILE A 432
ALA A 390
GLY A 409
ALA A 404
 None
 1.01A 4enhA-2canA:
undetectable		 4enhA-2canA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 LEU A 321
ILE A  94
THR A 256
GLY A  87
ALA A 352
 None
 1.03A 4enhA-2de2A:
undetectable		 4enhA-2de2A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 PHE A 103
LEU A 132
ALA A 159
GLY A 183
ALA A 128
 None
None
None
GOL  A 501 (-3.3A)
None
 1.03A 4enhA-2de2A:
undetectable		 4enhA-2de2A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fz1 COAT PROTEIN

(Turnip yellow
mosaic virus) 		PF00983
(Tymo_coat) 		5 ILE A 157
ILE A 118
ALA A  84
THR A  81
ALA A  42
 None
 1.11A 4enhA-2fz1A:
undetectable		 4enhA-2fz1A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		5 PHE A 389
PHE A 469
LEU A 502
ILE A 480
ALA A 505
 None
 0.91A 4enhA-2jgpA:
undetectable		 4enhA-2jgpA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv2 PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Bacillus
subtilis) 		PF01680
(SOR_SNZ) 		5 LEU A 132
ILE A 199
ALA A 140
GLY A 142
ALA A 135
 None
 1.04A 4enhA-2nv2A:
undetectable		 4enhA-2nv2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg8 DPGC

(Streptomyces
toyocaensis) 		PF00378
(ECH_1) 		6 PHE A 304
LEU A 372
ALA A 354
ALA A 293
GLY A 297
ALA A 288
 None
 1.48A 4enhA-2pg8A:
undetectable		 4enhA-2pg8A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		5 ILE A 347
ALA A 348
ALA A  17
GLY A  15
THR A  21
 None
None
TLA  A 527 (-3.3A)
TLA  A 527 (-3.2A)
None
 1.08A 4enhA-2pyxA:
undetectable		 4enhA-2pyxA:
22.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q9g CYTOCHROME P450 46A1

(Homo sapiens) 		PF00067
(p450) 		12 PHE A  80
PHE A 121
LEU A 219
ILE A 222
ILE A 301
ALA A 302
THR A 306
ALA A 367
TRP A 368
GLY A 369
ALA A 474
THR A 475
 None
None
None
None
None
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
HEM  A 505 (-3.5A)
None
None
None
None
 0.38A 4enhA-2q9gA:
66.8		 4enhA-2q9gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 167
ALA A 123
ALA A  93
GLY A  97
ALA A  64
 None
 1.14A 4enhA-2v7bA:
undetectable		 4enhA-2v7bA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ve3 PUTATIVE CYTOCHROME
P450 120

(Synechocystis
sp. PCC 6803) 		PF00067
(p450) 		5 PHE A  69
PHE A 336
ILE A  46
GLY A 320
ALA A  64
 None
None
None
REA  A1445 (-4.5A)
None
 1.11A 4enhA-2ve3A:
41.4		 4enhA-2ve3A:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2veo LIPASE A

(Moesziomyces
antarcticus) 		PF03583
(LIP) 		5 PHE A  88
ILE A 126
ILE A 381
ALA A 187
GLY A 185
 None
None
None
None
PG4  A1443 ( 4.3A)
 1.15A 4enhA-2veoA:
undetectable		 4enhA-2veoA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqx METALLOPROTEINASE

(Serratia
proteamaculans) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
PF16485
(PLN_propep) 		5 LEU A 241
ILE A  18
ILE A 221
ALA A 218
GLY A 143
 None
 0.99A 4enhA-2vqxA:
undetectable		 4enhA-2vqxA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 PHE A 545
LEU A 627
ILE A 744
ALA A 595
THR A 605
 None
 1.10A 4enhA-2vwkA:
undetectable		 4enhA-2vwkA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio) 		PF00514
(Arm) 		5 ILE A 464
ALA A 463
THR A 449
ALA A 445
GLY A 441
 None
 1.10A 4enhA-2z6gA:
undetectable		 4enhA-2z6gA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbl PUTATIVE ISOMERASE

(Salmonella
enterica) 		PF07221
(GlcNAc_2-epim) 		5 PHE A   4
LEU A 257
ALA A 321
ALA A 327
THR A 324
 None
 1.10A 4enhA-2zblA:
undetectable		 4enhA-2zblA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpb NITRILE HYDRATASE
SUBUNIT ALPHA
NITRILE HYDRATASE
SUBUNIT BETA

(Rhodococcus
erythropolis) 		PF02211
(NHase_beta)
PF02979
(NHase_alpha) 		5 LEU B  35
ALA A  28
ALA B  99
GLY B 101
ALA A  22
 None
 1.13A 4enhA-2zpbB:
undetectable		 4enhA-2zpbB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		5 LEU A 266
ILE A 262
ALA A 482
ALA A 554
THR A 484
 None
 1.16A 4enhA-3aqpA:
undetectable		 4enhA-3aqpA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7m CELLULASE

(Rhodothermus
marinus) 		PF01670
(Glyco_hydro_12) 		5 LEU A  75
ILE A 175
ALA A 101
TRP A 188
GLY A 111
 None
 1.03A 4enhA-3b7mA:
undetectable		 4enhA-3b7mA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bge PREDICTED ATPASE

(Haemophilus
influenzae) 		PF12002
(MgsA_C) 		5 LEU A 261
ILE A 336
ALA A 335
ALA A 298
GLY A 303
 None
 0.98A 4enhA-3bgeA:
undetectable		 4enhA-3bgeA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		5 LEU A 415
ALA A 393
ALA A 388
GLY A 365
ALA A 442
 None
 1.16A 4enhA-3gcwA:
undetectable		 4enhA-3gcwA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyv SULFIDE-QUINONE
REDUCTASE

(Aquifex
aeolicus) 		PF07992
(Pyr_redox_2) 		5 LEU A  32
ILE A  71
ILE A  15
ALA A  16
ALA A 325
 None
 0.93A 4enhA-3hyvA:
undetectable		 4enhA-3hyvA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 2
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01257
(2Fe-2S_thioredx)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		5 LEU 2  31
ILE 2  49
ALA 2  50
GLY 3 212
ALA 2  64
 None
 0.96A 4enhA-3i9v2:
undetectable		 4enhA-3i9v2:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ku0 RIBOSOME-INACTIVATIN
G PROTEIN GELONIN

(Suregada
multiflora) 		PF00161
(RIP) 		5 LEU A 157
ILE A 161
ILE A  66
ALA A  67
ALA A  90
 None
ADE  A 800 (-4.0A)
None
None
None
 1.08A 4enhA-3ku0A:
undetectable		 4enhA-3ku0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		5 ILE A 159
ALA A  13
ALA A 116
GLY A 120
ALA A  20
 None
 1.00A 4enhA-3nixA:
undetectable		 4enhA-3nixA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prb FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Methanocaldococcus
jannaschii) 		PF00254
(FKBP_C) 		5 PHE A 216
ILE A 200
ALA A 201
ALA A 211
GLY A 177
 None
 0.81A 4enhA-3prbA:
undetectable		 4enhA-3prbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4d POSSIBLE
CHLOROMUCONATE
CYCLOISOMERASE
MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY

(Cytophaga
hutchinsonii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 279
ALA A 275
ALA A 303
GLY A 300
ALA A 308
 None
 1.13A 4enhA-3q4dA:
undetectable		 4enhA-3q4dA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6y ASPARTASE

(Bacillus sp.
YM55-1) 		PF00206
(Lyase_1) 		5 LEU A 160
ILE A 373
ILE A 215
ALA A 280
GLY A 342
 LEU  A 160 ( 0.6A)
ILE  A 373 ( 0.7A)
ILE  A 215 ( 0.7A)
ALA  A 280 ( 0.0A)
GLY  A 342 ( 0.0A)
 1.16A 4enhA-3r6yA:
undetectable		 4enhA-3r6yA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rku OXIDOREDUCTASE
YMR226C

(Saccharomyces
cerevisiae) 		PF00106
(adh_short) 		5 ILE A 248
ILE A 196
GLY A 148
ALA A 239
THR A 240
 None
 1.05A 4enhA-3rkuA:
undetectable		 4enhA-3rkuA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		5 LEU A 364
ILE A 335
ALA A 336
GLY A 107
ALA A 371
 None
 0.85A 4enhA-3sggA:
undetectable		 4enhA-3sggA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v3t CELL DIVISION GTPASE
FTSZ, DIVERGED

(Clostridium
botulinum) 		PF00091
(Tubulin) 		5 LEU A  31
ILE A  33
ALA A  78
ALA A 112
GLY A 110
 None
 1.00A 4enhA-3v3tA:
undetectable		 4enhA-3v3tA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbb DIAMINOPIMELATE
DEHYDROGENASE

(Symbiobacterium
thermophilum) 		PF01408
(GFO_IDH_MocA)
PF16654
(DAPDH_C) 		5 LEU A   4
ALA A  64
ALA A 113
GLY A 274
ALA A 269
 None
 1.06A 4enhA-3wbbA:
undetectable		 4enhA-3wbbA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		5 LEU A 454
THR A 422
GLY A 533
ALA A 689
THR A 426
 None
None
K  A1772 ( 4.6A)
None
None
 1.01A 4enhA-4a01A:
undetectable		 4enhA-4a01A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 5 LEU D 201
ILE D 133
ALA D 130
GLY D 260
ALA D 239
 None
 1.09A 4enhA-4em6D:
undetectable		 4enhA-4em6D:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE

(Escherichia
coli) 		PF00378
(ECH_1) 		5 LEU A  17
ILE A  52
ALA A  97
GLY A 126
ALA A  60
 None
 1.01A 4enhA-4fzwA:
undetectable		 4enhA-4fzwA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT

(Streptococcus
pneumoniae) 		PF13458
(Peripla_BP_6) 		5 LEU A 145
ILE A 154
ALA A 124
GLY A  57
ALA A 140
 None
None
None
None
ILE  A 401 (-4.1A)
 0.94A 4enhA-4gnrA:
undetectable		 4enhA-4gnrA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hac MEVALONATE KINASE

(Methanosarcina
mazei) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ILE A 119
ALA A 120
ALA A  96
GLY A  93
THR A  99
 None
 0.91A 4enhA-4hacA:
undetectable		 4enhA-4hacA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irf MALARIAL CLPB2
ATPASE/HSP101
PROTEIN

(Plasmodium
falciparum) 		PF02861
(Clp_N) 		5 PHE A 131
LEU A  72
ILE A  68
ILE A  26
GLY A 120
 None
 1.07A 4enhA-4irfA:
undetectable		 4enhA-4irfA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE

(Pseudomonas
savastanoi) 		PF01593
(Amino_oxidase) 		5 LEU A 277
ILE A 274
ILE A  48
ALA A 523
ALA A 103
 None
None
None
FAD  A 601 (-3.1A)
None
 1.03A 4enhA-4iv9A:
undetectable		 4enhA-4iv9A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jat ALPHA-PYRONE
SYNTHESIS POLYKETIDE
SYNTHASE-LIKE PKS11

(Mycobacterium
tuberculosis) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A  84
ALA A 160
ALA A   5
GLY A 209
ALA A  87
 None
 1.04A 4enhA-4jatA:
undetectable		 4enhA-4jatA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jat ALPHA-PYRONE
SYNTHESIS POLYKETIDE
SYNTHASE-LIKE PKS11

(Mycobacterium
tuberculosis) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A  84
ALA A 160
ALA A   5
GLY A 210
ALA A  87
 None
 0.93A 4enhA-4jatA:
undetectable		 4enhA-4jatA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jq9 DIHYDROLIPOYL
DEHYDROGENASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 422
ILE A 413
ILE A 350
ALA A 351
ALA A 214
 None
 1.06A 4enhA-4jq9A:
undetectable		 4enhA-4jq9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li3 CYSTEINE SYNTHASE

(Haemophilus
influenzae) 		PF00291
(PALP) 		5 LEU X 104
ILE X  75
ALA X  76
ALA X  81
GLY X  85
 None
None
LLP  X  42 ( 3.2A)
None
None
 1.14A 4enhA-4li3X:
undetectable		 4enhA-4li3X:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m02 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		PF05345
(He_PIG) 		5 ALA A 548
THR A 550
GLY A 518
ALA A 563
THR A 561
 None
 0.97A 4enhA-4m02A:
undetectable		 4enhA-4m02A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		5 LEU A 262
ILE A 261
ALA A 331
GLY A 584
ALA A  26
 None
 1.02A 4enhA-4mifA:
undetectable		 4enhA-4mifA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo9 PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		5 PHE A 211
LEU A 286
ILE A 259
GLY A 295
THR A 290
 None
 1.14A 4enhA-4mo9A:
undetectable		 4enhA-4mo9A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzp ARGININOSUCCINATE
SYNTHASE

(Campylobacter
jejuni) 		PF00764
(Arginosuc_synth) 		5 LEU A  68
ILE A  40
ALA A 103
ALA A  11
ALA A  38
 None
 0.89A 4enhA-4nzpA:
undetectable		 4enhA-4nzpA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzs BETA-KETOTHIOLASE
BKTB

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 312
ILE A 315
ALA A 389
ALA A 297
GLY A 293
 None
 0.96A 4enhA-4nzsA:
undetectable		 4enhA-4nzsA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov4 2-ISOPROPYLMALATE
SYNTHASE

(Leptospira
biflexa) 		PF00682
(HMGL-like) 		5 LEU A 260
ILE A 262
GLY A 236
ALA A 250
THR A 249
 None
 1.07A 4enhA-4ov4A:
undetectable		 4enhA-4ov4A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		5 LEU B 415
ALA B 393
ALA B 388
GLY B 365
ALA B 442
 None
 1.11A 4enhA-4ov6B:
undetectable		 4enhA-4ov6B:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Mycobacterium
tuberculosis) 		PF01497
(Peripla_BP_2) 		5 LEU A 179
ILE A 209
ALA A 195
ALA A 217
ALA A 192
 None
 1.15A 4enhA-4pm4A:
undetectable		 4enhA-4pm4A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ILE A 330
ALA A 331
ALA A 265
GLY A 268
ALA A 260
 None
 1.08A 4enhA-4rcnA:
undetectable		 4enhA-4rcnA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpd CAPSID PROTEIN

(Norwalk virus) 		PF08435
(Calici_coat_C) 		5 PHE A 359
LEU A 389
ILE A 332
ILE A 433
ALA A 330
 None
 1.16A 4enhA-4rpdA:
undetectable		 4enhA-4rpdA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tv6 2-DEHYDRO-3-DEOXYGLU
CARATE ALDOLASE

(Staphylococcus
aureus) 		PF03328
(HpcH_HpaI) 		5 ILE A  30
ALA A  56
ALA A  89
GLY A  91
ALA A  62
 None
 1.13A 4enhA-4tv6A:
undetectable		 4enhA-4tv6A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcq TUBZ

(Clostridium
phage c-st) 		PF00091
(Tubulin) 		5 LEU A  31
ILE A  33
ALA A  78
ALA A 112
GLY A 110
 None
 1.02A 4enhA-4xcqA:
undetectable		 4enhA-4xcqA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysh GLYCINE OXIDASE

(Geobacillus
kaustophilus) 		PF01266
(DAO) 		5 ILE A  86
ALA A 168
ALA A  17
GLY A  13
ALA A 162
 None
None
None
FAD  A 401 (-3.3A)
None
 1.04A 4enhA-4yshA:
undetectable		 4enhA-4yshA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bul FLAVIN-DEPENDENT
HALOGENASE TRIPLE
MUTANT

(Streptomyces) 		PF04820
(Trp_halogenase) 		5 PHE A 104
LEU A  60
ILE A  57
ILE A 108
GLY A 378
 None
 1.06A 4enhA-5bulA:
undetectable		 4enhA-5bulA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck7 ADP-DEPENDENT
GLUCOKINASE

(Mus musculus) 		PF04587
(ADP_PFK_GK) 		5 PHE A 231
LEU A  96
ILE A 142
ALA A 143
ALA A 152
 None
 0.87A 4enhA-5ck7A:
undetectable		 4enhA-5ck7A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		6 LEU A 181
ILE A 263
ALA A 264
THR A 268
ALA A 328
THR A 438
 None
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.4A)
HEM  A 501 ( 3.8A)
None
 0.89A 4enhA-5e78A:
43.1		 4enhA-5e78A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Bacillus
subtilis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 LEU A 329
ILE A 127
ILE A 257
ALA A 256
GLY A 119
 LEU  A 329 ( 0.6A)
ILE  A 127 ( 0.6A)
ILE  A 257 ( 0.6A)
ALA  A 256 ( 0.0A)
GLY  A 119 ( 0.0A)
 1.04A 4enhA-5ep8A:
undetectable		 4enhA-5ep8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Bacillus
subtilis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 PHE A 309
LEU A 329
ILE A 127
ALA A 256
GLY A 119
 PHE  A 309 ( 1.3A)
LEU  A 329 ( 0.6A)
ILE  A 127 ( 0.6A)
ALA  A 256 ( 0.0A)
GLY  A 119 ( 0.0A)
 1.03A 4enhA-5ep8A:
undetectable		 4enhA-5ep8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		no annotation 5 PHE B 183
ILE B 187
GLY B 148
ALA B 168
THR B 145
 None
None
None
TCR  B 609 (-4.1A)
CL  B 605 ( 3.9A)
 1.13A 4enhA-5fbhB:
undetectable		 4enhA-5fbhB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyg ENDO-1,4-BETA-XYLANA
SE

(termite gut
metagenome) 		PF00457
(Glyco_hydro_11) 		5 PHE A 150
ILE A 243
GLY A  55
ALA A  74
THR A  75
 None
 1.10A 4enhA-5gygA:
undetectable		 4enhA-5gygA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3

(Saccharomyces
cerevisiae) 		PF13513
(HEAT_EZ) 		5 LEU A 495
ILE A 517
ALA A 518
ALA A 567
GLY A 569
 None
 0.77A 4enhA-5h2vA:
undetectable		 4enhA-5h2vA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn4 HOMOISOCITRATE
DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00180
(Iso_dh) 		5 ILE A  58
ILE A 243
ALA A 244
GLY A  67
ALA A   5
 None
 1.11A 4enhA-5hn4A:
undetectable		 4enhA-5hn4A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005

(uncultured
bacterium) 		PF02522
(Antibiotic_NAT) 		5 LEU A  46
ILE A 102
ALA A 120
ALA A  25
GLY A 152
 None
 1.05A 4enhA-5ht0A:
undetectable		 4enhA-5ht0A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htp PROBABLE SUGAR
KINASE

(Synechococcus
elongatus) 		PF02782
(FGGY_C) 		5 ILE A  66
ALA A  67
THR A 407
GLY A  10
ALA A  16
 None
 1.12A 4enhA-5htpA:
undetectable		 4enhA-5htpA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7v DESIGNED PROTEIN
HR00C3

(synthetic
construct) 		no annotation 5 LEU A 119
ILE A  74
ALA A  73
ALA A   6
ALA A  58
 None
 1.01A 4enhA-5k7vA:
undetectable		 4enhA-5k7vA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7v DESIGNED PROTEIN
HR00C3

(synthetic
construct) 		no annotation 5 LEU A 212
ILE A 167
ALA A 166
ALA A  99
ALA A 151
 None
 0.98A 4enhA-5k7vA:
undetectable		 4enhA-5k7vA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		5 LEU A 455
ILE A 368
ILE A 411
ALA A 427
GLY A 440
 None
 1.10A 4enhA-5kcaA:
undetectable		 4enhA-5kcaA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		5 PHE A 972
LEU A 956
ILE A 818
THR A 976
THR A 981
 None
 1.08A 4enhA-5kf7A:
undetectable		 4enhA-5kf7A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2r FUMARATE HYDRATASE

(Leishmania
major) 		PF05681
(Fumerase)
PF05683
(Fumerase_C) 		5 LEU A 244
ILE A 240
ILE A 257
ALA A 258
GLY A 262
 None
 1.10A 4enhA-5l2rA:
undetectable		 4enhA-5l2rA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7l ELP3 FAMILY, ELP3
FAMILY

(Dehalococcoides
mccartyi) 		PF04055
(Radical_SAM)
PF16199
(Radical_SAM_C) 		5 LEU A 401
ILE A 419
ALA A 418
GLY A 413
ALA A 404
 None
 0.82A 4enhA-5l7lA:
undetectable		 4enhA-5l7lA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE

(Enterobacter
cloacae) 		PF00724
(Oxidored_FMN) 		5 LEU A 268
ILE A 232
ILE A 257
ALA A 253
GLY A 185
 None
 1.14A 4enhA-5lgxA:
undetectable		 4enhA-5lgxA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR

(Mus musculus) 		no annotation 5 PHE B  40
LEU B  68
ILE B 108
GLY B 196
ALA B  31
 None
 1.15A 4enhA-5lhsB:
undetectable		 4enhA-5lhsB:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 ILE B 428
ILE B 453
ALA B 451
ALA B 490
GLY B 435
 None
 1.11A 4enhA-5mkkB:
undetectable		 4enhA-5mkkB:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		5 LEU A 693
ILE A 696
ALA A 738
ALA A 756
GLY A 758
 None
 0.82A 4enhA-5o0sA:
undetectable		 4enhA-5o0sA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Thermus
thermophilus) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 PHE A  93
LEU A  68
ILE A 113
ALA A 114
ALA A 122
 None
 0.86A 4enhA-5t3oA:
undetectable		 4enhA-5t3oA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2g PENICILLIN-BINDING
PROTEIN 1A

(Haemophilus
influenzae) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		5 ALA A 562
ALA A 741
TRP A 776
GLY A 727
THR A 750
 None
 1.01A 4enhA-5u2gA:
undetectable		 4enhA-5u2gA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viu ACETYLORNITHINE
AMINOTRANSFERASE

(Elizabethkingia
anophelis) 		PF00202
(Aminotran_3) 		5 LEU A 374
ILE A 404
ALA A 362
GLY A 381
ALA A 376
 None
 1.03A 4enhA-5viuA:
undetectable		 4enhA-5viuA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrv PROTEIN REGULATED BY
ACID PH

(Agrobacterium
fabrum) 		PF09924
(DUF2156) 		5 ILE A 587
ALA A 846
GLY A 812
ALA A 852
THR A 853
 None
 1.16A 4enhA-5vrvA:
undetectable		 4enhA-5vrvA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfs PE FAMILY PROTEIN
PE8
PPE FAMILY PROTEIN
PPE15

(Mycobacterium
tuberculosis) 		PF00823
(PPE)
no annotation 		5 PHE A  55
ALA B 100
ALA B 157
GLY B 159
ALA B  94
 None
 1.14A 4enhA-5xfsA:
undetectable		 4enhA-5xfsA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E

(Staphylococcus
aureus) 		no annotation 5 ILE A  32
ALA A 273
ALA A  22
ALA A  27
THR A  26
 None
 1.10A 4enhA-5xoeA:
undetectable		 4enhA-5xoeA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvi GLUTAMATE
DEHYDROGENASE

(Aspergillus
niger) 		no annotation 5 LEU A  74
THR A 447
ALA A 444
GLY A 419
ALA A 104
 None
 1.14A 4enhA-5xviA:
undetectable		 4enhA-5xviA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzd ENOYL-COA HYDRATASE

(Roseovarius
nubinhibens) 		no annotation 5 LEU A  19
ILE A  54
ALA A 100
GLY A 129
ALA A  62
 None
 1.10A 4enhA-5xzdA:
undetectable		 4enhA-5xzdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica) 		no annotation 5 PHE A 315
LEU A 118
ILE A 136
ALA A 277
THR A 281
 None
 0.95A 4enhA-5yhpA:
undetectable		 4enhA-5yhpA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 5 LEU A1452
ILE A1372
ILE A1471
ALA A1455
THR A1456
 None
 0.97A 4enhA-6bhuA:
undetectable		 4enhA-6bhuA:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 5 LEU A 426
ILE A 405
ALA A 398
ALA A 364
GLY A 368
 None
 0.98A 4enhA-6cmzA:
undetectable		 4enhA-6cmzA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ep3 -

(-) 		no annotation 5 ILE A 202
ALA A 198
ALA A  99
GLY A 102
ALA A  94
 None
None
None
None
EDO  A 303 (-3.8A)
 0.96A 4enhA-6ep3A:
undetectable		 4enhA-6ep3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ey5 T9SS COMPONENT
CYTOPLASMIC MEMBRANE
PROTEIN PORM

(Porphyromonas
gingivalis) 		no annotation 5 LEU A 357
ILE A 336
THR A 393
ALA A 391
ALA A 350
 None
 0.77A 4enhA-6ey5A:
undetectable		 4enhA-6ey5A:
11.74