SIMILAR PATTERNS OF AMINO ACIDS FOR 4EM2_A_SALA504

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4s BETAINE ALDEHYDE
DEHYDROGENASE

(Gadus morhua) 		PF00171
(Aldedh) 		4 PHE A 188
GLY A 198
LEU A 201
ILE A 200
 None
 0.81A 4em2A-1a4sA:
0.0		 4em2A-1a4sA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 GLY A 295
LEU A 296
ILE A 297
ILE A 315
 None
 0.67A 4em2A-1ad3A:
0.0		 4em2A-1ad3A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 LEU A 152
ILE A 153
ILE A 121
THR A 120
 None
 0.77A 4em2A-1ad3A:
0.0		 4em2A-1ad3A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		4 PHE A 429
GLY A 355
LEU A 354
ILE A 357
 None
 0.87A 4em2A-1ehkA:
0.0		 4em2A-1ehkA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1goj KINESIN HEAVY CHAIN

(Neurospora
crassa) 		PF00225
(Kinesin) 		4 GLY A  88
ILE A 305
THR A 317
THR A 320
 None
 0.86A 4em2A-1gojA:
undetectable		 4em2A-1gojA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4u NIDOGEN-1

(Mus musculus) 		PF07474
(G2F) 		4 GLY A 461
ILE A 464
ILE A 518
THR A 441
 None
 0.84A 4em2A-1h4uA:
undetectable		 4em2A-1h4uA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7k CATALASE

(Proteus
mirabilis) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 PHE A  64
GLY A 293
LEU A 258
ILE A  70
 None
 0.82A 4em2A-1h7kA:
undetectable		 4em2A-1h7kA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6a HYDROGEN
PEROXIDE-INDUCIBLE
GENES ACTIVATOR

(Escherichia
coli) 		PF03466
(LysR_substrate) 		4 GLY A 102
LEU A  97
ILE A  98
ILE A 268
 None
 0.69A 4em2A-1i6aA:
undetectable		 4em2A-1i6aA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		4 GLY A 170
LEU A 173
ILE A 174
ILE A 209
 None
 0.72A 4em2A-1jftA:
undetectable		 4em2A-1jftA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 GLY A 170
LEU A 173
ILE A 174
ILE A 209
 None
 0.82A 4em2A-1jhzA:
undetectable		 4em2A-1jhzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kri VP4

(Rotavirus A) 		PF00426
(VP4_haemagglut) 		4 GLY A  90
LEU A 107
ILE A 106
ILE A 130
 None
 0.76A 4em2A-1kriA:
undetectable		 4em2A-1kriA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvo PHOP RESPONSE
REGULATOR

(Bacillus
subtilis) 		PF00072
(Response_reg) 		4 PHE A  87
GLY A  92
LEU A  95
ILE A  77
 None
None
None
NA  A 202 ( 4.6A)
 0.80A 4em2A-1mvoA:
0.0		 4em2A-1mvoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7r HYALURONIDASE

(Streptococcus
pneumoniae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 PHE A 381
LEU A 416
ILE A 413
ILE A 485
 None
 0.80A 4em2A-1n7rA:
0.0		 4em2A-1n7rA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og3 T-CELL
ECTO-ADP-RIBOSYLTRAN
SFERASE 2

(Rattus
norvegicus) 		PF01129
(ART) 		4 PHE A  67
GLY A  72
LEU A  75
ILE A  57
 None
 0.80A 4em2A-1og3A:
undetectable		 4em2A-1og3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0n ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Bacillus
subtilis) 		PF01070
(FMN_dh) 		4 GLY A  50
LEU A  52
ILE A 182
THR A 253
 None
 0.85A 4em2A-1p0nA:
undetectable		 4em2A-1p0nA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 GLY A   7
LEU A 330
ILE A  45
THR A  61
 None
 0.83A 4em2A-1u1hA:
undetectable		 4em2A-1u1hA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		4 GLY A 264
ILE A 265
ARG A 487
THR A 275
 None
 0.80A 4em2A-1xrsA:
undetectable		 4em2A-1xrsA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzm PUTATIVE
DEOXYRIBONUCLEASE
YJJV

(Escherichia
coli) 		PF01026
(TatD_DNase) 		4 PHE A  46
GLY A  64
LEU A  65
ILE A  98
 None
 0.84A 4em2A-1zzmA:
undetectable		 4em2A-1zzmA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 GLY A1328
LEU A1331
ILE A1005
THR A1022
 None
 0.87A 4em2A-2bruA:
undetectable		 4em2A-2bruA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2crp REGULATOR OF
G-PROTEIN SIGNALING
5

(Homo sapiens) 		PF00615
(RGS) 		4 ILE A  85
ILE A  95
THR A  99
THR A 103
 None
 0.65A 4em2A-2crpA:
undetectable		 4em2A-2crpA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9d BAG FAMILY MOLECULAR
CHAPERONE REGULATOR
5

(Homo sapiens) 		PF02179
(BAG) 		4 GLY A  45
LEU A  46
ILE A  47
ILE A  76
 None
 0.63A 4em2A-2d9dA:
undetectable		 4em2A-2d9dA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum) 		PF13378
(MR_MLE_C) 		4 GLY A  62
LEU A  63
ILE A  64
THR A  12
 None
 0.61A 4em2A-2dw6A:
undetectable		 4em2A-2dw6A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv2 RCD1 REQUIRED FOR
CELL
DIFFERENTIATION1
HOMOLOG

(Homo sapiens) 		PF04078
(Rcd1) 		4 GLY A 179
ILE A 183
ARG A 189
ILE A 148
 None
 0.74A 4em2A-2fv2A:
undetectable		 4em2A-2fv2A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Sulfurisphaera
tokodaii) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		4 GLY A 159
ILE A 119
ILE A 144
THR A 185
 None
 0.63A 4em2A-2ggqA:
undetectable		 4em2A-2ggqA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8l PROTEIN
DISULFIDE-ISOMERASE
A3

(Homo sapiens) 		PF13848
(Thioredoxin_6) 		4 PHE A 160
GLY A 158
ILE A 156
ILE A 232
 None
 0.78A 4em2A-2h8lA:
undetectable		 4em2A-2h8lA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqf CATALASE

(Helicobacter
pylori) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 PHE A  66
GLY A 295
LEU A 260
ILE A  72
 None
 0.85A 4em2A-2iqfA:
undetectable		 4em2A-2iqfA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw0 CHITIN DEACETYLASE

(Colletotrichum
lindemuthianum) 		PF01522
(Polysacc_deac_1) 		4 PHE A  72
ILE A  62
THR A 212
THR A 217
 None
 0.84A 4em2A-2iw0A:
undetectable		 4em2A-2iw0A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o03 PROBABLE ZINC UPTAKE
REGULATION PROTEIN
FURB

(Mycobacterium
tuberculosis) 		PF01475
(FUR) 		4 ILE A  16
ILE A  43
THR A  47
THR A  51
 None
 0.76A 4em2A-2o03A:
6.3		 4em2A-2o03A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owp HYPOTHETICAL PROTEIN
BXE_B1374

(Paraburkholderia
xenovorans) 		PF11533
(DUF3225) 		4 PHE A  91
GLY A 100
LEU A 124
ILE A 125
 None
 0.86A 4em2A-2owpA:
undetectable		 4em2A-2owpA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qj8 MLR6093 PROTEIN

(Mesorhizobium
japonicum) 		PF04952
(AstE_AspA) 		4 PHE A 206
GLY A  60
LEU A  63
ILE A  49
 None
 0.84A 4em2A-2qj8A:
undetectable		 4em2A-2qj8A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 LEU B 730
ILE B 734
ILE B 717
THR B 745
 None
 0.78A 4em2A-2rhqB:
undetectable		 4em2A-2rhqB:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2var FRUCTOKINASE

(Sulfolobus
solfataricus) 		PF00294
(PfkB) 		4 GLY A  88
LEU A  11
ILE A  12
ILE A  65
 None
KDG  A1313 ( 4.7A)
None
None
 0.73A 4em2A-2varA:
undetectable		 4em2A-2varA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8p CHOLINE-BINDING
PROTEIN F

(Streptococcus
pneumoniae) 		PF01473
(CW_binding_1) 		4 PHE A 146
GLY A 144
LEU A 143
ILE A 156
 None
None
GOL  A1316 (-4.6A)
GOL  A1316 (-4.4A)
 0.84A 4em2A-2x8pA:
undetectable		 4em2A-2x8pA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT

(Rattus
norvegicus) 		PF01602
(Adaptin_N) 		4 PHE A 548
GLY A 505
LEU A 504
ILE A 503
 None
 0.86A 4em2A-2xa7A:
undetectable		 4em2A-2xa7A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro) 		4 GLY C  38
LEU C  65
ILE C  64
THR C  41
 None
None
None
SF4  C1413 ( 4.6A)
 0.77A 4em2A-2ynmC:
undetectable		 4em2A-2ynmC:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74

(Saccharomyces
cerevisiae) 		PF05719
(GPP34) 		4 GLY A 333
LEU A 123
ARG A 126
ILE A 112
 None
 0.54A 4em2A-2ziiA:
2.9		 4em2A-2ziiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 PHE A 536
GLY A 586
LEU A 550
ILE A 551
 None
 0.86A 4em2A-2ztgA:
undetectable		 4em2A-2ztgA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7k REGULATOR OF
G-PROTEIN SIGNALING
16

(Mus musculus) 		PF00615
(RGS) 		4 ILE B 121
ILE B 131
THR B 135
THR B 139
 None
 0.66A 4em2A-3c7kB:
undetectable		 4em2A-3c7kB:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8b FIDGETIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 GLY A 405
ILE A 403
ILE A 565
THR A 445
 None
None
None
ADP  A 900 (-4.3A)
 0.74A 4em2A-3d8bA:
undetectable		 4em2A-3d8bA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0h UNCHARACTERIZED
PROTEIN

(Chlorobaculum
tepidum) 		PF06445
(GyrI-like) 		4 PHE A  58
LEU A  21
ILE A  22
ILE A  42
 None
 0.76A 4em2A-3e0hA:
undetectable		 4em2A-3e0hA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyy PUTATIVE IRON UPTAKE
REGULATORY PROTEIN

(Streptomyces
coelicolor) 		PF01475
(FUR) 		4 LEU A  23
ILE A  50
THR A  54
THR A  58
 None
 0.70A 4em2A-3eyyA:
6.5		 4em2A-3eyyA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fet ELECTRON TRANSFER
FLAVOPROTEIN SUBUNIT
ALPHA RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01012
(ETF) 		4 GLY A  83
ILE A  72
THR A 130
THR A  93
 None
 0.86A 4em2A-3fetA:
undetectable		 4em2A-3fetA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhl PUTATIVE
OXIDOREDUCTASE

(Bacteroides
fragilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 GLY A 178
LEU A 181
ILE A 182
ILE A 214
 None
 0.71A 4em2A-3fhlA:
undetectable		 4em2A-3fhlA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfk REGULATORY PROTEIN
SPX

(Bacillus
subtilis) 		PF03960
(ArsC) 		4 LEU A  82
ILE A  83
ILE A  57
THR A  53
 None
 0.79A 4em2A-3gfkA:
undetectable		 4em2A-3gfkA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE

(Yersinia pestis) 		PF00709
(Adenylsucc_synt) 		4 GLY A 234
ARG A 318
ILE A 322
THR A 245
 None
 0.71A 4em2A-3hidA:
undetectable		 4em2A-3hidA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		4 PHE A 103
GLY A  44
LEU A  85
ILE A  84
 None
 0.87A 4em2A-3hutA:
undetectable		 4em2A-3hutA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 GLY A 661
ILE A 662
ILE A 571
THR A 625
 None
 0.85A 4em2A-3iayA:
undetectable		 4em2A-3iayA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kin KINESIN HEAVY CHAIN

(Rattus
norvegicus) 		PF00225
(Kinesin) 		4 GLY A  86
ILE B 302
THR B 314
THR B 317
 None
 0.83A 4em2A-3kinA:
undetectable		 4em2A-3kinA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kje CO
DEHYDROGENASE/ACETYL
-COA SYNTHASE
COMPLEX, ACCESSORY
PROTEIN COOC

(Carboxydothermus
hydrogenoformans) 		PF01656
(CbiA) 		4 GLY A  19
LEU A  20
ILE A  21
THR A  45
 None
 0.81A 4em2A-3kjeA:
1.1		 4em2A-3kjeA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knu TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Anaplasma
phagocytophilum) 		PF01746
(tRNA_m1G_MT) 		4 PHE A  36
LEU A  77
ILE A   2
THR A  81
 None
 0.75A 4em2A-3knuA:
undetectable		 4em2A-3knuA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nc3 CYTOCHROME P450 CYPX

(Bacillus
subtilis) 		PF00067
(p450) 		4 PHE A 324
LEU A 249
ILE A 246
THR A 241
 None
None
None
HEM  A 406 (-3.5A)
 0.81A 4em2A-3nc3A:
undetectable		 4em2A-3nc3A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Vibrio cholerae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 GLY A 233
LEU A 236
ILE A 237
ILE A 245
 None
None
None
EDO  A 504 (-4.7A)
 0.76A 4em2A-3p4eA:
undetectable		 4em2A-3p4eA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb0 DIHYDRODIPICOLINATE
SYNTHASE

(Thermotoga
maritima) 		PF00701
(DHDPS) 		4 GLY A  98
LEU A 127
ILE A  -4
THR A   0
 None
 0.85A 4em2A-3pb0A:
undetectable		 4em2A-3pb0A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H

(Human
gammaherpesvirus
4) 		no annotation 4 GLY A 391
LEU A 392
ILE A 393
THR A 438
 None
 0.85A 4em2A-3phfA:
undetectable		 4em2A-3phfA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwb PROBABLE QUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 160
LEU A 163
ILE A 164
ILE A 301
 NDP  A 335 (-3.3A)
None
None
None
 0.45A 4em2A-3qwbA:
undetectable		 4em2A-3qwbA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr3 MICROCIN IMMUNITY
PROTEIN MCCF

(Bacillus
anthracis) 		PF02016
(Peptidase_S66) 		4 GLY A  14
LEU A  45
ILE A  44
THR A  83
 None
 0.87A 4em2A-3sr3A:
undetectable		 4em2A-3sr3A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3szb ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		4 GLY A 295
LEU A 296
ILE A 297
ILE A 315
 None
 0.71A 4em2A-3szbA:
undetectable		 4em2A-3szbA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 GLY A  47
ILE A  49
ILE A  33
THR A  58
 None
 0.86A 4em2A-3u5tA:
undetectable		 4em2A-3u5tA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 LEU A 944
ILE A 945
ARG A 971
ILE A 975
 None
 0.71A 4em2A-3w9hA:
1.4		 4em2A-3w9hA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD) 		4 PHE A 536
GLY A 586
LEU A 550
ILE A 551
 None
 0.82A 4em2A-3wqyA:
undetectable		 4em2A-3wqyA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe PROTEIN SMG-7

(Caenorhabditis
elegans) 		PF10373
(EST1_DNA_bind) 		4 GLY B 171
LEU B 172
ILE B 173
ARG B 141
 None
 0.71A 4em2A-3zheB:
undetectable		 4em2A-3zheB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a34 RBSD/FUCU TRANSPORT
PROTEIN FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF05025
(RbsD_FucU) 		4 ILE A 103
ILE A  93
THR A  98
THR A 102
 None
 0.87A 4em2A-4a34A:
undetectable		 4em2A-4a34A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac3 BIFUNCTIONAL PROTEIN
GLMU

(Streptococcus
pneumoniae) 		PF00132
(Hexapep)
PF00483
(NTP_transferase)
PF14602
(Hexapep_2) 		4 GLY A 171
ILE A 127
ILE A 152
THR A 199
 None
 0.76A 4em2A-4ac3A:
undetectable		 4em2A-4ac3A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF05292
(MCD)
PF17408
(MCD_N) 		4 GLY A 304
LEU A 307
ILE A 308
ILE A 291
 None
 0.71A 4em2A-4f0xA:
undetectable		 4em2A-4f0xA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C)
PF13654
(AAA_32) 		4 PHE A  29
LEU A  39
ILE A  43
THR A  69
 None
 0.83A 4em2A-4fwgA:
undetectable		 4em2A-4fwgA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqe CARBOXYVINYL-CARBOXY
PHOSPHONATE
PHOSPHORYLMUTASE

(Bacillus
anthracis) 		PF13714
(PEP_mutase) 		4 GLY A  96
ILE A  93
ILE A 150
THR A 106
 None
 0.83A 4em2A-4iqeA:
undetectable		 4em2A-4iqeA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je3 CENTRAL KINETOCHORE
SUBUNIT CHL4
CENTRAL KINETOCHORE
SUBUNIT IML3

(Saccharomyces
cerevisiae) 		PF05238
(CENP-N)
no annotation 		4 GLY A 176
LEU A 175
ARG B 396
ILE B 398
 None
 0.85A 4em2A-4je3A:
undetectable		 4em2A-4je3A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwx GLUN2A

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 PHE A  76
LEU A  67
ILE A  66
ILE A 247
 None
 0.68A 4em2A-4jwxA:
undetectable		 4em2A-4jwxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 PHE A  76
LEU A  67
ILE A  66
ILE A 247
 None
 0.86A 4em2A-4jwyA:
undetectable		 4em2A-4jwyA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 PHE A 127
GLY A 246
LEU A 115
THR A 243
 None
None
1N4  A 301 ( 4.9A)
None
 0.87A 4em2A-4jwyA:
undetectable		 4em2A-4jwyA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k92 CLIP-ASSOCIATING
PROTEIN 1

(Homo sapiens) 		PF12348
(CLASP_N) 		4 PHE A 306
GLY A 393
LEU A 435
ILE A 436
 None
 0.82A 4em2A-4k92A:
undetectable		 4em2A-4k92A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF13646
(HEAT_2) 		4 PHE A  80
LEU A  39
ILE A  38
ILE A  60
 None
 0.80A 4em2A-4l7mA:
undetectable		 4em2A-4l7mA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6x ANKYRIN-3

(Homo sapiens) 		PF00531
(Death) 		4 GLY A  92
ILE A  94
ARG A   7
THR A  65
 None
 0.81A 4em2A-4o6xA:
undetectable		 4em2A-4o6xA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o89 RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Pyrococcus
horikoshii) 		PF01137
(RTC)
PF05189
(RTC_insert) 		4 GLY A 285
LEU A 288
ILE A 289
ILE A 335
 None
 0.63A 4em2A-4o89A:
undetectable		 4em2A-4o89A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2v CYSTEINE SYNTHETASE

(Helicobacter
pylori) 		PF00291
(PALP) 		4 GLY A  50
LEU A  53
ILE A  54
ILE A  69
 LLP  A  46 ( 3.9A)
None
None
None
 0.78A 4em2A-4r2vA:
0.4		 4em2A-4r2vA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE

(Zophobas
atratus) 		PF00501
(AMP-binding) 		4 GLY A 235
LEU A 234
ILE A 233
ARG A 244
 None
 0.71A 4em2A-4w8oA:
undetectable		 4em2A-4w8oA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1

(Homo sapiens) 		PF00569
(ZZ)
PF06701
(MIB_HERC2) 		4 PHE A  42
GLY A  13
ILE A  70
THR A  76
 None
 0.82A 4em2A-4xibA:
undetectable		 4em2A-4xibA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A 313
LEU A 314
ILE A 315
ILE A  19
 None
 0.71A 4em2A-4zo6A:
undetectable		 4em2A-4zo6A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az4 FLAGELLAR HOOK
SUBUNIT PROTEIN

(Campylobacter
jejuni) 		PF07196
(Flagellin_IN)
PF07559
(FlaE) 		4 PHE A 765
GLY A 763
ILE A 761
ILE A 159
 None
 0.87A 4em2A-5az4A:
undetectable		 4em2A-5az4A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7s LON PROTEASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C) 		4 GLY A 599
LEU A 610
ILE A 612
THR A 682
 None
 0.79A 4em2A-5e7sA:
undetectable		 4em2A-5e7sA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32

(Mycobacterium
marinum) 		PF00501
(AMP-binding) 		4 PHE A 249
LEU A  91
ILE A  92
ILE A  54
 None
 0.83A 4em2A-5ey9A:
undetectable		 4em2A-5ey9A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hnz PROTEIN CLARET
SEGREGATIONAL,PROTEI
N CLARET
SEGREGATIONAL,PLUS-E
ND DIRECTED
KINESIN-1/KINESIN-14
,PROTEIN CLARET
SEGREGATIONAL,PROTEI
N CLARET
SEGREGATIONAL

(Drosophila
melanogaster;
Rattus
norvegicus) 		PF00225
(Kinesin) 		4 GLY K 101
ILE K 316
THR K 328
THR K 331
 None
 0.79A 4em2A-5hnzK:
undetectable		 4em2A-5hnzK:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i45 GLYCOSYL
TRANSFERASES GROUP 1
FAMILY PROTEIN

(Francisella
tularensis) 		PF00534
(Glycos_transf_1) 		4 GLY A 167
ILE A 250
ARG A 317
ILE A 311
 None
 0.84A 4em2A-5i45A:
undetectable		 4em2A-5i45A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 GLY A1065
LEU A 845
ILE A 864
THR A 856
 None
 0.70A 4em2A-5ip9A:
undetectable		 4em2A-5ip9A:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l20 CLOSTRIPAIN-RELATED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF03415
(Peptidase_C11)
no annotation 		4 GLY B 243
LEU B 246
ILE B 247
ILE A  76
 None
 0.57A 4em2A-5l20B:
undetectable		 4em2A-5l20B:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6

(Bos taurus) 		PF00499
(Oxidored_q3) 		4 PHE J  20
GLY J  32
LEU J  33
ILE J  34
 None
 0.71A 4em2A-5lc5J:
undetectable		 4em2A-5lc5J:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my5 ABC TRANSPORTER
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Desulfovibrio
alaskensis) 		PF12849
(PBP_like_2) 		4 GLY A  88
LEU A 190
ILE A  86
ILE A 108
 None
 0.82A 4em2A-5my5A:
undetectable		 4em2A-5my5A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nck N-ACETYLMANNOSAMINE
KINASE

(Fusobacterium
nucleatum) 		PF00480
(ROK) 		4 GLY A  10
ILE A   8
ILE A  82
THR A  32
 None
 0.73A 4em2A-5nckA:
undetectable		 4em2A-5nckA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t38 EVDMO1

(Micromonospora
carbonacea) 		PF13847
(Methyltransf_31) 		4 GLY A  82
LEU A  81
ILE A  80
THR A  69
 None
 0.84A 4em2A-5t38A:
undetectable		 4em2A-5t38A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 PHE A 245
LEU A 124
ILE A 125
ILE A 193
 None
 0.80A 4em2A-5weoA:
undetectable		 4em2A-5weoA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE

(Saccharomyces
cerevisiae) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		4 GLY A 762
LEU A 763
ILE A 764
ILE A 787
 None
 0.86A 4em2A-5xvmA:
1.7		 4em2A-5xvmA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zov -

(-) 		no annotation 4 GLY A 356
ILE A 358
ILE A 280
THR A  88
 None
ASC  A 501 ( 4.9A)
None
None
 0.48A 4em2A-5zovA:
undetectable		 4em2A-5zovA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aoo MALATE DEHYDROGENASE

(Haemophilus
influenzae) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 101
ILE A 102
ILE A 116
THR A 124
 None
 0.70A 4em2A-6aooA:
undetectable		 4em2A-6aooA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0w HISTONE H3-LIKE
CENTROMERIC PROTEIN
A
HISTONE H4

(Homo sapiens) 		no annotation 4 GLY B  48
LEU B  49
ILE B  50
THR A 120
 GLY  B  48 ( 0.0A)
LEU  B  49 ( 0.6A)
ILE  B  50 ( 0.7A)
THR  A 120 ( 0.8A)
 0.81A 4em2A-6c0wB:
undetectable		 4em2A-6c0wB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5d LLAJI.R1

(Helicobacter
pylori) 		no annotation 4 GLY A 118
LEU A 119
ILE A 120
ILE A  90
 None
 0.86A 4em2A-6c5dA:
undetectable		 4em2A-6c5dA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 4 GLY A  25
LEU A  27
ILE A  29
THR A  31
 None
 0.86A 4em2A-6cmzA:
undetectable		 4em2A-6cmzA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
GAMMA-2,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT GAMMA-2

(Homo sapiens) 		no annotation 4 PHE E 306
ILE A 232
THR A 256
THR A 260
 None
None
Y01  E 401 ( 4.4A)
None
 0.86A 4em2A-6d6uE:
undetectable		 4em2A-6d6uE:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dgc ISC1926 TNPA
C-TERMINAL CATALYTIC
DOMAIN

(Sulfolobus sp.
L00 11) 		no annotation 4 GLY A 145
ILE A 149
THR A 113
THR A 142
 None
 0.65A 4em2A-6dgcA:
undetectable		 4em2A-6dgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8s PUTATIVE KILLER
PROTEIN
XRE FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
putida) 		no annotation 4 GLY A  12
ILE A  14
ARG B  31
ILE A   9
 None
 0.84A 4em2A-6f8sA:
undetectable		 4em2A-6f8sA:
20.92