SIMILAR PATTERNS OF AMINO ACIDS FOR 4EM2_A_SALA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cly IGG FAB (HUMAN IGG1,
KAPPA)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.15A 4em2A-1clyH:
undetectable		 4em2A-1clyH:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbj IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.19A 4em2A-1dbjH:
undetectable		 4em2A-1dbjH:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dr9 T LYMPHOCYTE
ACTIVATION ANTIGEN

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2) 		4 TYR A  80
LEU A  14
LEU A  72
ARG A  56
 None
 1.50A 4em2A-1dr9A:
undetectable		 4em2A-1dr9A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3r FV ANTIBODY FRAGMENT

(Rattus
norvegicus) 		PF07686
(V-set) 		4 TYR B  93
LEU B  20
LEU B  85
ARG B  66
 None
 1.37A 4em2A-1f3rB:
undetectable		 4em2A-1f3rB:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3p ANTIBODY FAB
FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.25A 4em2A-1h3pH:
undetectable		 4em2A-1h3pH:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kri VP4

(Rotavirus A) 		PF00426
(VP4_haemagglut) 		4 TYR A 206
LEU A  65
TYR A 219
LEU A 224
 None
 1.14A 4em2A-1kriA:
undetectable		 4em2A-1kriA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lo3 IG GAMMA 2A HEAVY
CHAIN

(Mus musculus) 		no annotation 4 TYR Y  96
LEU Y  83
LEU Y  88
ARG Y  69
 None
 1.23A 4em2A-1lo3Y:
undetectable		 4em2A-1lo3Y:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lo4 IG GAMMA 2A HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  93
LEU H  80
LEU H  85
ARG H  66
 None
 1.28A 4em2A-1lo4H:
undetectable		 4em2A-1lo4H:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd H57 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR F  90
LEU F  80
LEU F  82
ARG F  66
 None
 1.28A 4em2A-1nfdF:
undetectable		 4em2A-1nfdF:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN
(IMMUNOGLOBULIN
HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR A  94
LEU A  81
LEU A  86
ARG A  67
 None
 1.24A 4em2A-1qgcA:
undetectable		 4em2A-1qgcA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r24 PROTEIN (IGG3-KAPPA
ANTIBODY (HEAVY
CHAIN))

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  94
LEU B  81
LEU B  86
ARG B  67
 None
 1.24A 4em2A-1r24B:
undetectable		 4em2A-1r24B:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4k IMMUNOGLOBULIN IGG1,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  90
LEU B  80
LEU B  83
ARG B  66
 None
 1.18A 4em2A-1t4kB:
undetectable		 4em2A-1t4kB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zan FAB AD11 HEAVY CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.23A 4em2A-1zanH:
undetectable		 4em2A-1zanH:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zea MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.16A 4em2A-1zeaH:
undetectable		 4em2A-1zeaH:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zel HYPOTHETICAL PROTEIN
RV2827C

(Mycobacterium
tuberculosis) 		PF09407
(AbiEi_1)
PF13338
(AbiEi_4) 		4 TYR A 112
LEU A 110
LEU A 160
ARG A 157
 None
 1.35A 4em2A-1zelA:
2.5		 4em2A-1zelA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvh IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN

(Camelus
dromedarius) 		PF07686
(V-set) 		4 TYR A  94
LEU A  81
LEU A  86
ARG A  67
 None
 1.27A 4em2A-1zvhA:
undetectable		 4em2A-1zvhA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9o DNAJ (HSP40)
HOMOLOG, SUBFAMILY
C, MEMBER 17

(Homo sapiens) 		PF00076
(RRM_1) 		4 LEU A 237
TYR A 189
LEU A 197
ARG A 196
 None
 1.44A 4em2A-2d9oA:
undetectable		 4em2A-2d9oA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 175
TYR A 195
LEU A  58
ARG A  92
 None
 1.44A 4em2A-2eq9A:
undetectable		 4em2A-2eq9A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjz CATALYTIC
ELIMINATION ANTIBODY
13G5 HEAVY CHAIN

(Mus musculus) 		no annotation 4 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.21A 4em2A-2gjzH:
undetectable		 4em2A-2gjzH:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 TYR A 399
LEU A 397
LEU A 432
ARG A 430
 None
 1.42A 4em2A-2gv9A:
1.7		 4em2A-2gv9A:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igf IGG1-KAPPA B13I2 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.22A 4em2A-2igfH:
undetectable		 4em2A-2igfH:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9b POSSIBLE PROLIDASE

(Bifidobacterium
longum) 		PF01979
(Amidohydro_1) 		4 TYR A 366
LEU A 362
TYR A 449
LEU A 303
 None
 1.25A 4em2A-2p9bA:
0.0		 4em2A-2p9bA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 TYR A  13
LEU A  44
TYR A 460
LEU A 369
 None
 1.36A 4em2A-2pwhA:
0.0		 4em2A-2pwhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae) 		PF04097
(Nic96) 		4 TYR A 477
TYR A 277
LEU A 278
ARG A 342
 None
 1.44A 4em2A-2rfoA:
0.0		 4em2A-2rfoA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uud NQ10-1.12 ANTI-PHOX
ANTIBODY

(Mus musculus) 		PF07686
(V-set) 		4 TYR H  90
LEU H  20
LEU H  82
ARG H  66
 None
 1.35A 4em2A-2uudH:
undetectable		 4em2A-2uudH:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uud NQ10-1.12 ANTI-PHOX
ANTIBODY

(Mus musculus) 		PF07686
(V-set) 		4 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.26A 4em2A-2uudH:
undetectable		 4em2A-2uudH:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 TYR A  95
LEU A 119
TYR A 542
LEU A 497
 None
 1.32A 4em2A-2wpgA:
0.0		 4em2A-2wpgA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1o GELSOLIN NANOBODY

(Lama glama) 		PF07686
(V-set) 		4 TYR A  94
LEU A  81
LEU A  86
ARG A  67
 None
 1.26A 4em2A-2x1oA:
undetectable		 4em2A-2x1oA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F

(Drosophila
melanogaster) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		4 TYR A 397
LEU A 396
LEU A 719
ARG A 722
 None
 1.14A 4em2A-2x6kA:
0.6		 4em2A-2x6kA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2a FAB 447-52D HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.23A 4em2A-3c2aH:
undetectable		 4em2A-3c2aH:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb5 FACT COMPLEX SUBUNIT
SPT16

(Schizosaccharomyces
pombe) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		4 TYR A 407
LEU A 409
LEU A 348
ARG A 345
 None
 1.09A 4em2A-3cb5A:
0.1		 4em2A-3cb5A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		4 TYR A  94
LEU A 118
TYR A 541
LEU A 496
 None
 1.37A 4em2A-3czeA:
undetectable		 4em2A-3czeA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsf FAB FRAGMENT OF
ANTI-OSTEOPONTIN
ANTIBODY 23C3, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  96
LEU H  83
LEU H  88
ARG H  69
 None
 1.23A 4em2A-3dsfH:
undetectable		 4em2A-3dsfH:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 LEU A 855
TYR A 655
LEU A 618
ARG A 847
 None
 0.69A 4em2A-3dy5A:
0.4		 4em2A-3dy5A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo6 PROTEIN OF UNKNOWN
FUNCTION (DUF1255)

(Acidithiobacillus
ferrooxidans) 		PF06865
(DUF1255) 		4 TYR A 101
LEU A  42
TYR A  47
LEU A  49
 None
 1.28A 4em2A-3eo6A:
undetectable		 4em2A-3eo6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7w PUTATIVE
FRUCTOSAMINE-3-KINAS
E

(Thermobifida
fusca) 		PF03881
(Fructosamin_kin) 		4 LEU A  53
TYR A 126
LEU A 130
ARG A 155
 None
PEG  A 296 ( 4.1A)
None
None
 1.38A 4em2A-3f7wA:
undetectable		 4em2A-3f7wA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo0 CATALYTIC ANTIBODY
FAB 13G5 IGG2B HEAVY
CHAIN CHIMERA

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  93
LEU H  80
LEU H  85
ARG H  66
 None
 1.09A 4em2A-3fo0H:
undetectable		 4em2A-3fo0H:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijs IMMUNOGLOBULIN HEAVY
CHAIN (IGG3)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  90
LEU B  80
LEU B  82
ARG B  66
 None
 1.25A 4em2A-3ijsB:
undetectable		 4em2A-3ijsB:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu4 CHP3 FAB HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.17A 4em2A-3iu4H:
undetectable		 4em2A-3iu4H:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbg NANOBODY VHH PVSS21E

(Camelus
dromedarius) 		PF07686
(V-set) 		4 TYR 7  92
LEU 7  79
LEU 7  84
ARG 7  65
 None
 1.19A 4em2A-3jbg7:
undetectable		 4em2A-3jbg7:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B

(Legionella
pneumophila) 		PF00501
(AMP-binding) 		4 TYR A 462
LEU A 458
TYR A 498
ARG A 560
 None
 1.47A 4em2A-3kxwA:
undetectable		 4em2A-3kxwA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucq AMYLOSUCRASE

(Deinococcus
geothermalis) 		PF00128
(Alpha-amylase) 		4 TYR A  46
LEU A  42
LEU A 264
ARG A  56
 None
 1.22A 4em2A-3ucqA:
0.8		 4em2A-3ucqA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyr ANTIBODY FAB HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  94
LEU H  81
LEU H  86
ARG H  67
 None
 1.23A 4em2A-3uyrH:
undetectable		 4em2A-3uyrH:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zkm FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR C  93
LEU C  80
LEU C  85
ARG C  66
 None
None
None
GOL  C1217 (-3.8A)
 1.30A 4em2A-3zkmC:
undetectable		 4em2A-3zkmC:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axn CHITINASE C1

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		4 TYR A 207
LEU A 239
TYR A 250
LEU A 183
 None
 1.38A 4em2A-4axnA:
undetectable		 4em2A-4axnA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 4 TYR A 397
LEU A 497
TYR A 491
LEU A 486
 None
 1.46A 4em2A-4btpA:
0.0		 4em2A-4btpA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwf UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		4 LEU A 141
TYR A  73
LEU A 174
ARG A 177
 None
 1.33A 4em2A-4bwfA:
undetectable		 4em2A-4bwfA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c57 NANOBODY

(Lama glama) 		PF07686
(V-set) 		4 TYR C 102
LEU C  89
LEU C  94
ARG C  75
 None
 1.26A 4em2A-4c57C:
undetectable		 4em2A-4c57C:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4erc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
23

(Homo sapiens) 		PF00782
(DSPc) 		4 LEU A  16
TYR A 109
LEU A 110
ARG A 114
 None
 1.33A 4em2A-4ercA:
undetectable		 4em2A-4ercA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmf POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 1

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2)
PF13927
(Ig_3) 		4 TYR A 122
LEU A  49
LEU A 114
ARG A  96
 None
 1.41A 4em2A-4fmfA:
undetectable		 4em2A-4fmfA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxa 13D9 FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.32A 4em2A-4hxaH:
undetectable		 4em2A-4hxaH:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 HEAVY
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  90
LEU H  79
LEU H  82
ARG H  66
 None
 1.28A 4em2A-4jo2H:
undetectable		 4em2A-4jo2H:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvc IG HEAVY CHAIN V
REGION MOPC 21, IGH
PROTEIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  94
LEU H  81
LEU H  86
ARG H  67
 None
 1.20A 4em2A-4kvcH:
undetectable		 4em2A-4kvcH:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmq IMMUNOGLOBULIN G1
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR E  90
LEU E  80
LEU E  82
ARG E  66
 TYR  E  90 ( 1.3A)
LEU  E  80 ( 0.5A)
LEU  E  82 ( 0.6A)
ARG  E  66 ( 0.6A)
 1.17A 4em2A-4lmqE:
undetectable		 4em2A-4lmqE:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9g ANTIBODY 17HD9,
HEAVY CHAIN

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR A  90
LEU A  77
LEU A  82
ARG A  66
 None
 1.26A 4em2A-4n9gA:
undetectable		 4em2A-4n9gA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nec PUTATIVE
SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
lasaliensis) 		PF13649
(Methyltransf_25) 		4 LEU A 113
TYR A 125
LEU A  96
ARG A 121
 SAH  A 401 (-4.1A)
None
SAH  A 401 ( 4.5A)
None
 1.18A 4em2A-4necA:
undetectable		 4em2A-4necA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6b NON-STRUCTURAL
PROTEIN 1

(Dengue virus) 		PF00948
(Flavi_NS1) 		4 TYR A 323
LEU A 321
TYR A 260
ARG A 294
 None
 1.27A 4em2A-4o6bA:
undetectable		 4em2A-4o6bA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6d NS1

(West Nile virus) 		PF00948
(Flavi_NS1) 		4 TYR B 323
LEU B 321
TYR B 260
ARG B 294
 None
 1.35A 4em2A-4o6dB:
undetectable		 4em2A-4o6dB:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3c HEAVY CHAIN FAB
FRAGMENT OF ANTIBODY
LEM-2/15

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  94
LEU H  81
LEU H  86
ARG H  67
 None
 1.13A 4em2A-4p3cH:
undetectable		 4em2A-4p3cH:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yaq PG9_N100FY FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 4 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.21A 4em2A-4yaqH:
undetectable		 4em2A-4yaqH:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxb FAB 83-7 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR A  93
LEU A  80
LEU A  85
ARG A  66
 None
 1.38A 4em2A-4zxbA:
undetectable		 4em2A-4zxbA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayq SODIUM CHANNEL
SUBUNIT BETA-4

(Mus musculus) 		PF07686
(V-set) 		4 TYR A 129
LEU A  51
LEU A 121
ARG A 100
 None
 1.29A 4em2A-5ayqA:
undetectable		 4em2A-5ayqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cin FAB 4E10 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.34A 4em2A-5cinH:
undetectable		 4em2A-5cinH:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1z Y10 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  95
LEU B  82
LEU B  87
ARG B  68
 None
 1.28A 4em2A-5d1zB:
undetectable		 4em2A-5d1zB:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H 217
LEU H 204
LEU H 209
ARG H 190
 None
 1.28A 4em2A-5fhxH:
undetectable		 4em2A-5fhxH:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 TYR A 177
LEU A 173
LEU A 154
ARG A 151
 None
 1.48A 4em2A-5hm5A:
2.5		 4em2A-5hm5A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 TYR A1096
LEU A1099
LEU A1072
ARG A1107
 None
 1.48A 4em2A-5i6hA:
undetectable		 4em2A-5i6hA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijk 1E03 FAB FRAGMENT
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR A 102
LEU A  89
LEU A  94
ARG A  75
 None
 1.14A 4em2A-5ijkA:
undetectable		 4em2A-5ijkA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp2 CAMELID NANOBODY
VHH04

(Lama glama) 		no annotation 4 TYR C  94
LEU C  81
LEU C  86
ARG C  67
 None
 1.24A 4em2A-5mp2C:
undetectable		 4em2A-5mp2C:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5th9 GS-5745 FAB HEAVY
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  93
LEU H  80
LEU H  85
ARG H  66
 None
 1.14A 4em2A-5th9H:
undetectable		 4em2A-5th9H:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3j DH511.1 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.19A 4em2A-5u3jH:
undetectable		 4em2A-5u3jH:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3l DH511.2 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 4 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.27A 4em2A-5u3lH:
undetectable		 4em2A-5u3lH:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3n DH511.12P FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.19A 4em2A-5u3nH:
undetectable		 4em2A-5u3nH:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3p DH511.4 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.16A 4em2A-5u3pH:
undetectable		 4em2A-5u3pH:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vic FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.26A 4em2A-5vicH:
undetectable		 4em2A-5vicH:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vob FAB 8I21 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  94
LEU H  81
LEU H  86
ARG H  67
 None
 1.22A 4em2A-5vobH:
undetectable		 4em2A-5vobH:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wym ANTI-CONNEXIN26
SCFV,IG HEAVY
CHAIN,LINKER,ANTI-CO
NNEXIN26 SCFV,IG
LIGHT CHAIN

(Homo sapiens;
synthetic
construct) 		no annotation 4 TYR A  94
LEU A  81
LEU A  86
ARG A  67
 None
 1.31A 4em2A-5wymA:
undetectable		 4em2A-5wymA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0t 6H8 FAB FRAGMENT
HEAVY CHAIN

(Mus musculus) 		no annotation 4 TYR A 115
LEU A 102
LEU A 107
ARG A  88
 None
 1.21A 4em2A-5x0tA:
undetectable		 4em2A-5x0tA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5w NECTIN-1

(Sus scrofa) 		PF07686
(V-set) 		4 TYR B  86
LEU B  13
LEU B  78
ARG B  60
 None
 1.50A 4em2A-5x5wB:
undetectable		 4em2A-5x5wB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xaw SODIUM CHANNEL
SUBUNIT BETA-4

(Homo sapiens) 		PF07686
(V-set) 		4 TYR A 129
LEU A  51
LEU A 121
ARG A 100
 None
None
None
PG4  A 202 (-4.0A)
 1.36A 4em2A-5xawA:
undetectable		 4em2A-5xawA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bev THIOSULFATE
SULFURTRANSFERASE/RH
ODANESE-LIKE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 4 LEU A  52
TYR A  97
LEU A  75
ARG A  22
 None
 1.31A 4em2A-6bevA:
undetectable		 4em2A-6bevA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9u HEAVY CHAIN OF FAB
1B2

(Homo sapiens) 		no annotation 4 TYR H  98
LEU H  85
LEU H  90
ARG H  71
 None
 1.19A 4em2A-6c9uH:
undetectable		 4em2A-6c9uH:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ca6 PCT64_35S HEAVY
CHAIN

(Homo sapiens) 		no annotation 4 TYR H  90
LEU H  80
LEU H  82
ARG H  66
 None
 1.23A 4em2A-6ca6H:
undetectable		 4em2A-6ca6H:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehx SCFV ABVANCE:
INCREASING OUR
KNOWLEDGE OF
ANTIBODY STRUCTURAL
SPACE TO ENABLE
FASTER AND BETTER
DECISION MAKING IN
DRUG DISCOVERY

(Homo sapiens) 		no annotation 4 TYR B  94
LEU B  81
LEU B  86
ARG B  67
 None
 1.37A 4em2A-6ehxB:
undetectable		 4em2A-6ehxB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ek2 SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		no annotation 4 TYR H 263
LEU H 250
LEU H 255
ARG H 236
 None
 1.33A 4em2A-6ek2H:
undetectable		 4em2A-6ek2H:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 4 TYR A 356
LEU A 361
TYR A  27
ARG A  72
 None
 1.36A 4em2A-6gh2A:
undetectable		 4em2A-6gh2A:
16.77