SIMILAR PATTERNS OF AMINO ACIDS FOR 4EM0_B_KANB302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eax PEPTIDOGLYCAN
RECOGNITION
PROTEIN-I-BETA

(Homo sapiens) 		PF01510
(Amidase_2) 		5 TYR A 274
LEU A 277
THR A 308
LEU A 255
ARG A 244
 None
 1.48A 4em0B-2eaxA:
0.0		 4em0B-2eaxA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 267
THR A 249
TYR A 262
LEU A 201
VAL A 252
 None
 1.42A 4em0B-3mi9A:
0.0		 4em0B-3mi9A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohp HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Vibrio cholerae) 		PF00156
(Pribosyltran) 		5 LEU A  40
THR A 106
LEU A 114
ARG A 117
VAL A  79
 None
 1.33A 4em0B-3ohpA:
0.0		 4em0B-3ohpA:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4em2 UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349

(Staphylococcus
aureus) 		PF01047
(MarR) 		11 TYR A  52
TYR A  55
LEU A  56
THR A  59
TYR A  70
TRP A  73
LEU A  74
ARG A  77
ARG A  94
VAL A 145
GLN A 149
 SAL  A 501 (-4.6A)
SAL  A 502 (-4.2A)
SAL  A 501 (-4.4A)
SAL  A 502 (-3.2A)
SAL  A 501 (-4.8A)
SAL  A 502 (-3.6A)
SAL  A 504 ( 3.8A)
SAL  A 501 ( 3.0A)
SAL  A 504 (-4.0A)
SAL  A 502 (-4.6A)
SAL  A 502 (-4.5A)
 0.44A 4em0B-4em2A:
24.0		 4em0B-4em2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le5 S-ADENOSYLMETHIONINE
SYNTHETASE

(Campylobacter
jejuni) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 TYR A 288
LEU A 359
LEU A  30
VAL A 372
GLN A 377
 None
 1.31A 4em0B-4le5A:
0.0		 4em0B-4le5A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb7 UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF13149
(Mfa_like_1) 		5 TYR A 347
LEU A 334
THR A 299
LEU A 215
VAL A 293
 None
 1.46A 4em0B-4qb7A:
0.0		 4em0B-4qb7A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roa SERPIN 2

(Anopheles
gambiae) 		PF00079
(Serpin) 		5 LEU A  66
THR A  65
TYR A 144
LEU A 106
VAL A  89
 None
 1.43A 4em0B-4roaA:
0.1		 4em0B-4roaA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmr PUTATIVE
METHYL-ACCEPTING
CHEMOTAXIS SIGNAL
TRANSDUCTION PROTEIN

(Campylobacter
jejuni) 		PF02743
(dCache_1) 		5 THR A 178
TYR A 118
LEU A 128
ARG A 141
VAL A 176
 None
ILE  A 301 (-3.6A)
ILE  A 301 ( 4.8A)
None
None
 1.31A 4em0B-4xmrA:
0.0		 4em0B-4xmrA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm0 ALPHA-MANNOSIDASE,AL
PHA-MANNOSIDASE,ALPH
A-MANNOSIDASE

(Saccharomyces
cerevisiae) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 TYR A 331
LEU A 512
THR A 508
TYR A 498
GLN A 321
 None
 1.44A 4em0B-5jm0A:
0.0		 4em0B-5jm0A:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l25 BORON TRANSPORTER 1

(Arabidopsis
thaliana) 		PF00955
(HCO3_cotransp) 		5 TYR A 103
THR A  99
TYR A 308
LEU A 339
VAL A  95
 None
 1.47A 4em0B-5l25A:
undetectable		 4em0B-5l25A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A 347
THR A 350
TYR A 374
LEU A 444
ARG A 488
 None
 1.45A 4em0B-5opjA:
undetectable		 4em0B-5opjA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfp EXOCYST COMPLEX
COMPONENT SEC6

(Saccharomyces
cerevisiae) 		no annotation 5 TYR C 738
TYR C 742
THR C 793
LEU C 665
GLN C 712
 None
 1.32A 4em0B-5yfpC:
undetectable		 4em0B-5yfpC:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dch SCOE PROTEIN

(Streptomyces
coeruleorubidus) 		no annotation 5 TYR A 168
LEU A 233
THR A 222
LEU A 255
ARG A 258
 None
 1.49A 4em0B-6dchA:
undetectable		 4em0B-6dchA:
27.27