SIMILAR PATTERNS OF AMINO ACIDS FOR 4EJW_A_SRYA2001_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5z L-LACTATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLU A 241
ILE A 240
GLU A 194
HIS A 195
 CD  A   1 (-2.4A)
NAD  A 352 ( 4.6A)
None
CD  A   3 ( 3.7A)
 1.10A 4ejwB-1a5zA:
1.8		 4ejwB-1a5zA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ccw PROTEIN (GLUTAMATE
MUTASE)

(Clostridium
cochlearium) 		PF06368
(Met_asp_mut_E) 		4 ILE B 406
ASN B 414
GLU B 432
VAL B 466
 None
 1.04A 4ejwB-1ccwB:
0.2		 4ejwB-1ccwB:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)

(Salmonella
enterica) 		PF00180
(Iso_dh) 		4 GLU A 323
ILE A 326
ASN A 327
GLU A 118
 None
 0.74A 4ejwB-1cnzA:
0.0		 4ejwB-1cnzA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT
II

(Salmonella
enterica) 		PF00117
(GATase) 		4 GLU B 112
ILE B 111
HIS B  86
VAL B 139
 None
 1.07A 4ejwB-1i1qB:
0.0		 4ejwB-1i1qB:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5y TRANSCRIPTIONAL
REGULATOR, BIOTIN
REPRESSOR FAMILY

(Thermotoga
maritima) 		PF02829
(3H)
PF08279
(HTH_11) 		4 GLU A 173
ILE A 172
HIS A 148
VAL A  91
 None
None
NI  A 201 (-3.3A)
None
 1.09A 4ejwB-1j5yA:
5.7		 4ejwB-1j5yA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ku2 SIGMA FACTOR SIGA

(Thermus
aquaticus) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2) 		4 GLU A 196
ILE A 150
GLU A 102
VAL A 106
 None
 1.11A 4ejwB-1ku2A:
1.7		 4ejwB-1ku2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdw CALPAIN II,
CATALYTIC SUBUNIT

(Rattus
norvegicus) 		PF00648
(Peptidase_C2) 		4 GLU A 119
ILE A 120
ASN A 117
GLU A 213
 None
 1.11A 4ejwB-1mdwA:
undetectable		 4ejwB-1mdwA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk0 CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA) 		4 GLU A 397
ILE A 398
ASN A 349
VAL A 343
 None
 1.11A 4ejwB-1pk0A:
0.0		 4ejwB-1pk0A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		4 GLU A  89
ILE A  93
HIS A 136
VAL A 104
 None
 1.07A 4ejwB-1przA:
undetectable		 4ejwB-1przA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1

(Saccharomyces
cerevisiae) 		PF00268
(Ribonuc_red_sm) 		4 GLU A 267
ASN A 266
GLU A 307
VAL A 334
 None
 1.11A 4ejwB-1smqA:
1.3		 4ejwB-1smqA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		4 GLU A 264
ASN A 307
GLU A 337
VAL A 162
 FSO  A1546 ( 3.1A)
FSO  A1546 (-3.0A)
None
None
 1.01A 4ejwB-1upxA:
undetectable		 4ejwB-1upxA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9k RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE C

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		4 GLU A  98
ILE A 102
HIS A 141
VAL A 113
 None
 1.05A 4ejwB-1v9kA:
undetectable		 4ejwB-1v9kA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqy HYPOTHETICAL PROTEIN
AGR_PAT_315

(Agrobacterium
fabrum) 		PF07978
(NIPSNAP) 		4 GLU A  88
ILE A  10
GLU A   5
HIS A  53
 None
 1.02A 4ejwB-1vqyA:
undetectable		 4ejwB-1vqyA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE

(Aeropyrum
pernix) 		PF00793
(DAHP_synth_1) 		4 GLU A 171
ILE A 168
GLU A 108
VAL A 118
 None
None
PEP  A 302 ( 4.3A)
None
 1.05A 4ejwB-1vs1A:
undetectable		 4ejwB-1vs1A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
GAMMA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 ILE E 225
ASN E 224
GLU E 182
VAL E 279
 None
 0.83A 4ejwB-2bg9E:
undetectable		 4ejwB-2bg9E:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		4 GLU A 225
ILE A 222
GLU A 123
VAL A  30
 None
None
NA  A1540 (-4.8A)
None
 0.99A 4ejwB-2ehqA:
undetectable		 4ejwB-2ehqA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frv PERIPLASMIC
HYDROGENASE

(Desulfovibrio
gigas) 		no annotation 4 GLU L  24
ILE L  23
GLU L  18
VAL L 535
 None
 1.07A 4ejwB-2frvL:
undetectable		 4ejwB-2frvL:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghp U4/U6
SNRNA-ASSOCIATED
SPLICING FACTOR
PRP24

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		4 GLU A 281
ILE A 282
GLU A 267
VAL A 189
 None
 0.83A 4ejwB-2ghpA:
undetectable		 4ejwB-2ghpA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE

(Xanthomonas
campestris) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 333
ILE A 337
ASN A 334
GLU A 274
 None
None
None
MG  A 601 (-3.1A)
 1.12A 4ejwB-2hneA:
undetectable		 4ejwB-2hneA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF00849
(PseudoU_synth_2)
PF01479
(S4) 		4 GLU A  89
ILE A  93
HIS A 136
VAL A 104
 None
 1.10A 4ejwB-2istA:
undetectable		 4ejwB-2istA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 ILE A1710
ASN A1711
GLU A1766
VAL A1905
 None
 1.06A 4ejwB-2ix8A:
undetectable		 4ejwB-2ix8A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mlw TYPE-1BA CYTOLYTIC
DELTA-ENDOTOXIN

(Dickeya
dadantii) 		PF01338
(Bac_thur_toxin) 		4 GLU A   4
ILE A   5
ASN A  11
VAL A  41
 None
 1.12A 4ejwB-2mlwA:
undetectable		 4ejwB-2mlwA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p62 HYPOTHETICAL PROTEIN
PH0156

(Pyrococcus
horikoshii) 		PF11536
(DUF3226) 		4 GLU A  66
ILE A   7
GLU A  90
VAL A  82
 None
 1.04A 4ejwB-2p62A:
undetectable		 4ejwB-2p62A:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prv UNCHARACTERIZED
PROTEIN YOBK

(Bacillus
subtilis) 		PF14567
(SUKH_5) 		4 GLU A 131
ILE A 130
GLU A  32
VAL A  88
 None
None
EDO  A 161 (-3.2A)
None
 0.92A 4ejwB-2prvA:
undetectable		 4ejwB-2prvA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzc TRANSCRIPTIONAL
ACTIVATOR TENA-1

(Sulfolobus
solfataricus) 		PF03070
(TENA_THI-4) 		4 ILE A  39
GLU A 198
HIS A  24
VAL A 143
 None
IMD  A 214 (-2.7A)
None
None
 1.12A 4ejwB-2qzcA:
undetectable		 4ejwB-2qzcA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E

(Bacillus cereus) 		PF04204
(HTS) 		4 GLU A 199
ILE A 202
GLU A 226
VAL A 177
 None
 0.83A 4ejwB-2vdjA:
undetectable		 4ejwB-2vdjA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wim NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF07679
(I-set) 		4 GLU A  86
ILE A  85
ASN A  84
VAL A 107
 None
 1.04A 4ejwB-2wimA:
undetectable		 4ejwB-2wimA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbl PUTATIVE ISOMERASE

(Salmonella
enterica) 		PF07221
(GlcNAc_2-epim) 		4 GLU A 130
ILE A  79
ASN A  83
VAL A 184
 None
 1.11A 4ejwB-2zblA:
undetectable		 4ejwB-2zblA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a18 ALDOXIME DEHYDRATASE

(Rhodococcus
erythropolis) 		PF13816
(Dehydratase_hem) 		4 ILE A  94
ASN A  92
HIS A 282
VAL A 208
 None
 1.03A 4ejwB-3a18A:
undetectable		 4ejwB-3a18A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a27 UNCHARACTERIZED
PROTEIN MJ1557

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		4 ILE A 107
ASN A 139
GLU A  58
VAL A  11
 None
 1.07A 4ejwB-3a27A:
undetectable		 4ejwB-3a27A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzj UV ENDONUCLEASE

(Thermus
thermophilus) 		PF03851
(UvdE) 		4 GLU A 185
ASN A 207
GLU A 269
VAL A 141
 None
None
MN  A 281 ( 4.9A)
None
 0.99A 4ejwB-3bzjA:
undetectable		 4ejwB-3bzjA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME

(Schistosoma
japonicum) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 GLU A 184
ILE A 189
GLU A  30
VAL A  14
 None
 0.92A 4ejwB-3cruA:
undetectable		 4ejwB-3cruA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxl N-CHIMERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		4 GLU A 291
ILE A 292
GLU A 410
HIS A 407
 None
 1.09A 4ejwB-3cxlA:
undetectable		 4ejwB-3cxlA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dli METHYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF13489
(Methyltransf_23) 		4 ILE A 395
ASN A 392
GLU A 380
VAL A 269
 None
 1.08A 4ejwB-3dliA:
undetectable		 4ejwB-3dliA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dt5 UNCHARACTERIZED
PROTEIN AF_0924

(Archaeoglobus
fulgidus) 		no annotation 4 GLU A 110
ILE A 109
GLU A 166
VAL A 127
 None
None
EDO  A 302 (-3.7A)
None
 1.02A 4ejwB-3dt5A:
undetectable		 4ejwB-3dt5A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)

(Escherichia
coli;
Homo sapiens) 		PF00085
(Thioredoxin) 		4 GLU A 542
ILE A 526
ASN A 530
GLU A 483
 None
 0.99A 4ejwB-3dxbA:
undetectable		 4ejwB-3dxbA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		4 GLU X 136
ILE X 137
ASN X 173
GLU X 162
 None
 0.91A 4ejwB-3e13X:
undetectable		 4ejwB-3e13X:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 GLU A1417
ILE A1418
GLU A1350
VAL A1381
 None
 1.06A 4ejwB-3ecqA:
undetectable		 4ejwB-3ecqA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh8 METAL ABC
TRANSPORTER
SUBSTRATE-BINDING
LIPOPROTEIN

(Streptococcus
pyogenes) 		PF01297
(ZnuA) 		4 ILE A  90
GLU A  68
HIS A  67
VAL A  60
 None
None
FE  A 401 (-3.3A)
None
 0.83A 4ejwB-3hh8A:
undetectable		 4ejwB-3hh8A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7f ASPARTYL-TRNA
SYNTHETASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ILE A 339
ASN A 342
GLU A 351
VAL A 461
 None
 1.06A 4ejwB-3i7fA:
1.3		 4ejwB-3i7fA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ife PEPTIDASE T

(Bacillus
anthracis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLU A   7
ILE A   6
GLU A 385
VAL A  91
 None
 1.06A 4ejwB-3ifeA:
undetectable		 4ejwB-3ifeA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izy TRANSLATION
INITIATION FACTOR
IF-2, MITOCHONDRIAL

(Bos taurus) 		PF00009
(GTP_EFTU)
PF11987
(IF-2) 		4 GLU P 713
ILE P 617
GLU P 545
VAL P 515
 None
 0.99A 4ejwB-3izyP:
undetectable		 4ejwB-3izyP:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 C381 TURRET PROTEIN

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 4 GLU P 261
ILE P 262
ASN P 263
GLU P 374
 None
 0.97A 4ejwB-3j31P:
undetectable		 4ejwB-3j31P:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsa HOMOSERINE
DEHYDROGENASE

(Thermoplasma
volcanium) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 ILE A 322
ASN A 318
HIS A 225
VAL A 160
 None
 1.10A 4ejwB-3jsaA:
undetectable		 4ejwB-3jsaA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		4 GLU X1270
ILE X1268
GLU X 182
HIS X1299
 None
 1.09A 4ejwB-3lxuX:
undetectable		 4ejwB-3lxuX:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lz8 PUTATIVE CHAPERONE
DNAJ

(Klebsiella
pneumoniae) 		PF01556
(DnaJ_C) 		4 GLU A 120
ILE A 121
GLU A 129
VAL A 167
 None
 1.05A 4ejwB-3lz8A:
undetectable		 4ejwB-3lz8A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases) 		4 GLU B1020
ILE B1019
GLU B1014
VAL B1560
 None
 1.09A 4ejwB-3myrB:
undetectable		 4ejwB-3myrB:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no3 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Parabacteroides
distasonis) 		PF03009
(GDPD) 		4 GLU A  59
ILE A 156
GLU A 181
VAL A 201
 MG  A 301 ( 2.6A)
None
None
None
 0.95A 4ejwB-3no3A:
undetectable		 4ejwB-3no3A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE

(Thermoplasma
acidophilum) 		PF01494
(FAD_binding_3) 		4 GLU A 144
ILE A 145
GLU A 162
VAL A   9
 None
None
FAD  A 501 (-3.9A)
FAD  A 501 ( 4.8A)
 1.11A 4ejwB-3oz2A:
undetectable		 4ejwB-3oz2A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p54 ENVELOPE
GLYCOPROTEIN

(Japanese
encephalitis
virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		4 GLU A  49
ILE A  48
ASN A  47
VAL A 176
 None
 1.11A 4ejwB-3p54A:
undetectable		 4ejwB-3p54A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm8 CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF13499
(EF-hand_7) 		4 GLU A 352
ASN A 345
GLU A 371
VAL A 446
 None
 1.00A 4ejwB-3pm8A:
undetectable		 4ejwB-3pm8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qax PROBABLE ABC
TRANSPORTER
ARGININE-BINDING
PROTEIN ARTJ

(Chlamydia
pneumoniae) 		PF00497
(SBP_bac_3) 		4 GLU A 206
ILE A 210
GLU A  24
VAL A  53
 None
None
ARG  A 600 (-3.9A)
None
 1.04A 4ejwB-3qaxA:
undetectable		 4ejwB-3qaxA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt3 PUTATIVE
UNCHARACTERIZED
PROTEIN CPE0426

(Clostridium
perfringens) 		PF06824
(Glyco_hydro_125) 		4 GLU A 393
ILE A 359
ASN A 302
VAL A  53
 None
None
EDO  A 428 (-3.7A)
None
 0.91A 4ejwB-3qt3A:
undetectable		 4ejwB-3qt3A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rxy NIF3 PROTEIN

(Sphaerobacter
thermophilus) 		no annotation 4 GLU A 230
ILE A 226
ASN A 204
VAL A 218
 None
None
CL  A 277 (-4.2A)
None
 1.04A 4ejwB-3rxyA:
undetectable		 4ejwB-3rxyA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsv XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF13229
(Beta_helix) 		4 GLU A 252
ILE A 251
ASN A 314
VAL A 365
 None
 1.11A 4ejwB-3vsvA:
undetectable		 4ejwB-3vsvA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsv XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF13229
(Beta_helix) 		4 GLU A 291
ASN A 295
GLU A 461
HIS A 455
 None
 1.00A 4ejwB-3vsvA:
undetectable		 4ejwB-3vsvA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu2 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 ILE A  60
ASN A  61
GLU A 251
VAL A 243
 None
 0.91A 4ejwB-3vu2A:
undetectable		 4ejwB-3vu2A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvj OVALBUMIN

(Dromaius
novaehollandiae) 		PF00079
(Serpin) 		4 GLU A 151
ILE A 158
GLU A 326
VAL A 174
 None
 1.13A 4ejwB-3vvjA:
undetectable		 4ejwB-3vvjA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1

(Sulfolobus
solfataricus) 		PF10040
(CRISPR_Cas6) 		4 GLU A 275
ILE A 276
GLU A 127
VAL A 119
 None
 0.95A 4ejwB-3zfvA:
undetectable		 4ejwB-3zfvA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arp PESTICIN

(Yersinia pestis) 		PF16754
(Pesticin) 		4 ILE A 153
ASN A 152
GLU A 101
VAL A 147
 None
 1.04A 4ejwB-4arpA:
undetectable		 4ejwB-4arpA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzg ALDOSE 1-EPIMERASE

(Bacillus
subtilis) 		PF01263
(Aldose_epim) 		4 GLU A  93
ILE A  91
ASN A  92
VAL A 292
 MAL  A 500 (-3.7A)
None
None
None
 1.03A 4ejwB-4bzgA:
undetectable		 4ejwB-4bzgA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 GLU H 184
ILE H 183
ASN H 182
GLU H 141
 None
 0.95A 4ejwB-4cr4H:
undetectable		 4ejwB-4cr4H:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crn ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX

(Saccharomyces
cerevisiae) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 GLU X 385
ILE X 318
GLU X 415
VAL X 412
 None
 1.07A 4ejwB-4crnX:
undetectable		 4ejwB-4crnX:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e08 DJ-1 BETA

(Drosophila
melanogaster) 		PF01965
(DJ-1_PfpI) 		4 GLU A  94
ILE A 100
ASN A 148
VAL A 138
 None
 1.08A 4ejwB-4e08A:
undetectable		 4ejwB-4e08A:
19.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eju TRANSCRIPTIONAL
REGULATOR TCAR

(Staphylococcus
epidermidis) 		PF12802
(MarR_2) 		5 GLU A  13
ILE A  16
GLU A  39
HIS A  42
VAL A  63
 None
 0.71A 4ejwB-4ejuA:
19.6		 4ejwB-4ejuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fyc THIOL:DISULFIDE
INTERCHANGE PROTEIN
(DSBC)

(Helicobacter
pylori) 		PF13098
(Thioredoxin_2) 		4 GLU A 138
ILE A 139
GLU A 144
VAL A 118
 None
 0.94A 4ejwB-4fycA:
undetectable		 4ejwB-4fycA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		4 GLU A  14
ILE A 157
ASN A 159
GLU A 202
 None
 1.07A 4ejwB-4gpgA:
undetectable		 4ejwB-4gpgA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i05 CATHEPSIN B-LIKE
PEPTIDASE (C01
FAMILY)

(Schistosoma
mansoni) 		PF00112
(Peptidase_C1) 		4 GLU A 142
ILE A 193
HIS A 181
VAL A 247
 None
 1.05A 4ejwB-4i05A:
undetectable		 4ejwB-4i05A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2

(Sulfolobus
solfataricus) 		PF10040
(CRISPR_Cas6) 		4 GLU A 276
ILE A 277
GLU A 128
VAL A 120
 None
 0.97A 4ejwB-4ilrA:
undetectable		 4ejwB-4ilrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLU A  96
ASN A 141
GLU A  60
HIS A  64
 None
EDO  A 302 ( 4.3A)
None
None
 1.02A 4ejwB-4jxfA:
undetectable		 4ejwB-4jxfA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksi LEUCINE
AMINOPEPTIDASE 1,
CHLOROPLASTIC

(Solanum
lycopersicum) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 GLU A 242
ILE A 241
GLU A 566
VAL A 251
 None
None
None
MPD  A 613 ( 4.9A)
 0.98A 4ejwB-4ksiA:
undetectable		 4ejwB-4ksiA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8n PDZ DOMAIN PROTEIN

(Parabacteroides
distasonis) 		PF00595
(PDZ)
PF13590
(DUF4136) 		4 GLU A 180
ILE A 183
ASN A 184
VAL A 277
 None
 1.06A 4ejwB-4l8nA:
undetectable		 4ejwB-4l8nA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lm8 EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT MTRC

(Shewanella
oneidensis) 		PF14522
(Cytochrome_C7) 		4 GLU A 503
ILE A 330
ASN A 331
GLU A 336
 EDO  A 823 (-3.6A)
EDO  A 823 ( 4.2A)
EDO  A 823 (-3.3A)
None
 0.95A 4ejwB-4lm8A:
undetectable		 4ejwB-4lm8A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lpl GLYCOSYL HYDROLASE,
FAMILY
31/FIBRONECTIN TYPE
III DOMAIN PROTEIN

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		4 GLU A1011
ILE A1010
GLU A1090
VAL A1060
 None
None
CA  A1101 (-3.4A)
None
 1.08A 4ejwB-4lplA:
undetectable		 4ejwB-4lplA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		4 ILE A 229
ASN A 241
GLU A  14
VAL A 313
 None
None
MLI  A 502 (-4.7A)
None
 0.99A 4ejwB-4m9dA:
undetectable		 4ejwB-4m9dA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN

(Thermomonospora
curvata) 		PF13458
(Peripla_BP_6) 		4 GLU A  94
ILE A  93
ASN A  83
VAL A  41
 None
 1.03A 4ejwB-4n03A:
undetectable		 4ejwB-4n03A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf2 ORNITHINE
CARBAMOYLTRANSFERASE

(Bacillus
anthracis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 GLU A 195
ILE A 196
ASN A 193
VAL A 115
 None
 1.13A 4ejwB-4nf2A:
undetectable		 4ejwB-4nf2A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI

(Staphylococcus
aureus) 		PF02976
(MutH) 		4 GLU A 378
ILE A 381
ASN A 382
GLU A 332
 None
 1.11A 4ejwB-4pxgA:
undetectable		 4ejwB-4pxgA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		4 ILE A 204
GLU A  23
HIS A  25
VAL A  70
 None
None
MN  A 902 (-3.3A)
None
 1.04A 4ejwB-4w8yA:
undetectable		 4ejwB-4w8yA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wo4 ANTIGEN-PRESENTING
GLYCOPROTEIN CD1D

(Homo sapiens) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 GLU A 132
ILE A 145
ASN A 149
VAL A  98
 None
 1.13A 4ejwB-4wo4A:
undetectable		 4ejwB-4wo4A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7e LMO1422 PROTEIN

(Listeria
monocytogenes) 		PF04069
(OpuAC) 		4 GLU A 247
ILE A 250
ASN A 251
GLU A 235
 None
 0.92A 4ejwB-4z7eA:
undetectable		 4ejwB-4z7eA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv9 UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF01738
(DLH) 		4 GLU A 106
ILE A 114
ASN A 111
VAL A 154
 CME  A 186 ( 4.8A)
None
None
None
 1.07A 4ejwB-4zv9A:
undetectable		 4ejwB-4zv9A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		4 GLU A 425
ILE A 428
ASN A 429
VAL A 602
 None
 0.89A 4ejwB-5a2rA:
undetectable		 4ejwB-5a2rA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		4 GLU A1056
ILE A1057
ASN A1058
HIS A1156
 None
 1.11A 4ejwB-5amqA:
undetectable		 4ejwB-5amqA:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c00 MDBA PROTEIN

(Corynebacterium
diphtheriae) 		PF13462
(Thioredoxin_4) 		4 GLU A 150
ASN A 154
GLU A  87
VAL A 116
 None
 1.11A 4ejwB-5c00A:
undetectable		 4ejwB-5c00A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA

(Homo sapiens) 		PF00169
(PH)
PF16746
(BAR_3) 		4 GLU B 102
ASN B 209
HIS A 100
VAL B  47
 None
 0.89A 4ejwB-5c5bB:
0.9		 4ejwB-5c5bB:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1p ATP-DEPENDENT RNA
LIGASE

(Methanothermobacter
thermautotrophicus) 		PF09414
(RNA_ligase) 		4 GLU A 151
ILE A 153
ASN A 157
GLU A 132
 APK  A  97 ( 3.0A)
None
None
None
 1.12A 4ejwB-5d1pA:
undetectable		 4ejwB-5d1pA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
T-COMPLEX PROTEIN 1
SUBUNIT EPSILON

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		4 GLU b  12
ILE b 515
ASN b 513
VAL e 123
 None
 1.09A 4ejwB-5gw5b:
undetectable		 4ejwB-5gw5b:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA
T-COMPLEX PROTEIN 1
SUBUNIT THETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		4 GLU q  74
ILE h 524
ASN h 526
VAL q  82
 None
 0.98A 4ejwB-5gw5q:
undetectable		 4ejwB-5gw5q:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE

(Arabidopsis
thaliana) 		PF02458
(Transferase) 		4 GLU A  83
ILE A  84
ASN A  24
HIS A  35
 None
 1.10A 4ejwB-5kjuA:
undetectable		 4ejwB-5kjuA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		4 ILE A 428
ASN A 425
GLU A 416
VAL A 441
 None
 0.83A 4ejwB-5lq3A:
0.7		 4ejwB-5lq3A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 GLU A 746
ASN A 787
GLU A 410
VAL A 418
 None
 1.07A 4ejwB-5n0cA:
undetectable		 4ejwB-5n0cA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE

(Cupriavidus
metallidurans) 		PF00724
(Oxidored_FMN) 		4 ILE A  19
ASN A  17
GLU A 173
VAL A  89
 None
 1.04A 4ejwB-5ocsA:
undetectable		 4ejwB-5ocsA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsc UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 GLU A  34
ILE A  35
GLU A  80
VAL A 345
 None
 0.94A 4ejwB-5tscA:
undetectable		 4ejwB-5tscA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM2
DNA REPLICATION
LICENSING FACTOR
MCM6

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 GLU 6 624
ILE 6 623
GLU 2 592
VAL 2 574
 None
 1.01A 4ejwB-5udb6:
undetectable		 4ejwB-5udb6:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azh TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Clostridium
perfringens) 		no annotation 4 GLU A  10
ILE A  13
ASN A  14
GLU A 162
 None
 0.64A 4ejwB-6azhA:
undetectable		 4ejwB-6azhA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE

(Carboxydothermus
hydrogenoformans) 		no annotation 4 GLU X 340
ILE X 341
HIS X 259
VAL X 356
 None
 1.11A 4ejwB-6elqX:
undetectable		 4ejwB-6elqX:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en3 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE
F2,MULTIFUNCTIONAL-A
UTOPROCESSING
REPEATS-IN-TOXIN

(Streptococcus
pyogenes;
Vibrio cholerae) 		no annotation 4 GLU A 606
ILE A 610
ASN A 607
VAL A 555
 None
 1.08A 4ejwB-6en3A:
undetectable		 4ejwB-6en3A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans) 		no annotation 4 GLU A  80
ILE A  83
ASN A  84
GLU A  66
 None
 0.86A 4ejwB-6enoA:
undetectable		 4ejwB-6enoA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans) 		no annotation 4 GLU A  80
ILE A  83
ASN A  84
VAL A 133
 None
 1.03A 4ejwB-6enoA:
undetectable		 4ejwB-6enoA:
18.92