SIMILAR PATTERNS OF AMINO ACIDS FOR 4EJJ_C_NCTC501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)

(Rattus
norvegicus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 PHE A  77
ILE A 251
GLY A 250
THR A 255
 None
 0.84A 4ejjC-1bu8A:
undetectable		 4ejjC-1bu8A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 PHE A 928
ILE A 782
GLY A1046
THR A1050
 None
 0.70A 4ejjC-1c30A:
0.0		 4ejjC-1c30A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 PHE A 603
PHE A 583
ILE A 601
THR A 538
 None
 0.86A 4ejjC-1ciyA:
0.0		 4ejjC-1ciyA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ei6 PHOSPHONOACETATE
HYDROLASE

(Pseudomonas
fluorescens) 		PF01663
(Phosphodiest) 		4 PHE A 226
PHE A 181
ILE A  22
THR A 200
 None
 1.01A 4ejjC-1ei6A:
0.0		 4ejjC-1ei6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek2 EPOXIDE HYDROLASE

(Mus musculus) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		4 PHE A 385
PHE A 406
ILE A 427
THR A 402
 None
CDU  A1100 (-4.6A)
None
None
 0.98A 4ejjC-1ek2A:
0.0		 4ejjC-1ek2A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exf EXFOLIATVE TOXIN A

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		4 PHE A 200
ILE A 139
GLY A 140
THR A  43
 None
 1.03A 4ejjC-1exfA:
0.0		 4ejjC-1exfA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE

(Methanopyrus
kandleri) 		PF00296
(Bac_luciferase) 		4 PHE A 251
PHE A 283
ILE A 278
GLY A 279
 None
 0.98A 4ejjC-1ezwA:
0.0		 4ejjC-1ezwA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0b CELLULASE

(Rhodothermus
marinus) 		PF01670
(Glyco_hydro_12) 		4 PHE A  43
PHE A 206
ILE A  45
GLY A 214
 None
 1.02A 4ejjC-1h0bA:
0.0		 4ejjC-1h0bA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jny ELONGATION FACTOR
1-ALPHA

(Sulfolobus
solfataricus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 PHE A 297
PHE A 267
ILE A 265
GLY A 274
 None
 0.94A 4ejjC-1jnyA:
0.0		 4ejjC-1jnyA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxk ALPHA-AMYLASE,
SALIVARY

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 PHE A 229
PHE A 330
ILE A  13
GLY A  38
 PCA  A   1 ( 4.7A)
None
None
None
 1.01A 4ejjC-1jxkA:
undetectable		 4ejjC-1jxkA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9y FEZ-1 B-LACTAMASE

(Fluoribacter
gormanii) 		PF00753
(Lactamase_B) 		4 PHE A 154
ILE A 239
GLY A 195
THR A 197
 None
 1.04A 4ejjC-1l9yA:
undetectable		 4ejjC-1l9yA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE

(Homo sapiens) 		PF02574
(S-methyl_trans) 		4 PHE A 155
ILE A 157
GLY A 121
THR A  73
 None
 0.82A 4ejjC-1lt8A:
undetectable		 4ejjC-1lt8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa4 ENDO-BETA-1,4-GLUCAN
ASE

(Streptomyces
sp. 11AG8) 		PF01670
(Glyco_hydro_12) 		4 PHE A  39
PHE A 202
ILE A  41
GLY A 210
 None
 0.95A 4ejjC-1oa4A:
undetectable		 4ejjC-1oa4A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum) 		PF01425
(Amidase) 		4 PHE A  39
ILE A 102
GLY A  60
THR A 105
 None
 0.94A 4ejjC-1ocmA:
undetectable		 4ejjC-1ocmA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhb HALOPEROXIDASE

(Corallina
officinalis) 		PF01569
(PAP2) 		4 PHE A 176
PHE A 224
ILE A 323
GLY A 168
 None
 1.04A 4ejjC-1qhbA:
undetectable		 4ejjC-1qhbA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1

(Canis lupus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 PHE A  77
ILE A 251
GLY A 250
THR A 255
 None
 0.88A 4ejjC-1rp1A:
undetectable		 4ejjC-1rp1A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzg MAJOR ENVELOPE
PROTEIN E

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		4 PHE A 212
ILE A 195
GLY A 127
THR A  55
 None
 1.01A 4ejjC-1uzgA:
undetectable		 4ejjC-1uzgA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwa ENDOGLUCANASE

(Rhodothermus
marinus) 		PF01670
(Glyco_hydro_12) 		4 PHE A  43
PHE A 206
ILE A  45
GLY A 214
 None
 1.00A 4ejjC-2bwaA:
undetectable		 4ejjC-2bwaA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		4 PHE A 210
ILE A 122
GLY A 121
THR A 302
 None
 0.99A 4ejjC-2bxyA:
undetectable		 4ejjC-2bxyA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		4 PHE A 221
ILE A 217
GLY A 216
THR A 210
 None
 0.99A 4ejjC-2d0oA:
undetectable		 4ejjC-2d0oA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d57 AQUAPORIN-4

(Rattus
norvegicus) 		PF00230
(MIP) 		4 PHE A  48
PHE A  77
GLY A  54
THR A  56
 None
 1.03A 4ejjC-2d57A:
undetectable		 4ejjC-2d57A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36

(Canis lupus) 		PF03388
(Lectin_leg-like) 		5 PHE A 118
PHE A 206
ILE A 133
GLY A 132
THR A 163
 None
 1.30A 4ejjC-2dupA:
undetectable		 4ejjC-2dupA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2b AQUAPORIN AQPM

(Methanothermobacter
marburgensis) 		PF00230
(MIP) 		4 PHE A 138
ILE A  44
GLY A  45
THR A  29
 None
 1.03A 4ejjC-2f2bA:
undetectable		 4ejjC-2f2bA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gkd CALC

(Micromonospora
echinospora) 		no annotation 4 PHE A  27
PHE A  65
ILE A 140
GLY A 136
 None
 1.02A 4ejjC-2gkdA:
undetectable		 4ejjC-2gkdA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jhq URACIL
DNA-GLYCOSYLASE

(Vibrio cholerae) 		PF03167
(UDG) 		4 PHE A  48
PHE A 144
ILE A  11
GLY A  12
 None
 0.97A 4ejjC-2jhqA:
undetectable		 4ejjC-2jhqA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nly DIVERGENT
POLYSACCHARIDE
DEACETYLASE
HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF04748
(Polysacc_deac_2) 		4 PHE A  41
PHE A  51
GLY A 219
THR A 228
 None
 0.97A 4ejjC-2nlyA:
undetectable		 4ejjC-2nlyA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxo HYPOTHETICAL PROTEIN
SCO4506

(Streptomyces
coelicolor) 		PF02621
(VitK2_biosynth) 		4 PHE A  33
PHE A 209
ILE A  54
GLY A  55
 None
 0.72A 4ejjC-2nxoA:
undetectable		 4ejjC-2nxoA:
22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		5 PHE A 107
PHE A 209
ILE A 300
GLY A 301
THR A 305
 None
None
None
HEM  A 500 ( 4.7A)
HEM  A 500 (-3.6A)
 0.34A 4ejjC-2pg6A:
64.2		 4ejjC-2pg6A:
99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 PHE A  96
ILE A 269
GLY A 268
THR A 273
 None
 0.87A 4ejjC-2pplA:
undetectable		 4ejjC-2pplA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 PHE A 553
PHE A 682
ILE A 549
GLY A 678
 None
 1.03A 4ejjC-2vz9A:
undetectable		 4ejjC-2vz9A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 PHE A 295
PHE A 257
ILE A 252
GLY A 253
 None
 1.04A 4ejjC-2w40A:
undetectable		 4ejjC-2w40A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbv FIBER PROTEIN

(Canine
mastadenovirus
A) 		no annotation 4 PHE A 418
PHE A 528
ILE A 383
THR A 530
 None
 0.74A 4ejjC-2wbvA:
undetectable		 4ejjC-2wbvA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB

(Salmonella
enterica) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 PHE A 398
PHE A 321
ILE A  45
GLY A  47
 None
 0.90A 4ejjC-2wnwA:
undetectable		 4ejjC-2wnwA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z87 CHONDROITIN SYNTHASE

(Escherichia
coli) 		PF00535
(Glycos_transf_2) 		4 PHE A 340
PHE A 351
ILE A 237
GLY A 335
 None
None
None
UD2  A 683 ( 4.8A)
 0.99A 4ejjC-2z87A:
undetectable		 4ejjC-2z87A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b57 LIN1889 PROTEIN

(Listeria
innocua) 		PF01966
(HD) 		4 PHE A 137
PHE A 161
ILE A 133
GLY A 132
 None
 0.98A 4ejjC-3b57A:
undetectable		 4ejjC-3b57A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7m CELLULASE

(Rhodothermus
marinus) 		PF01670
(Glyco_hydro_12) 		4 PHE A  43
PHE A 197
ILE A  45
GLY A 205
 None
 1.02A 4ejjC-3b7mA:
undetectable		 4ejjC-3b7mA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdz P450CIN

(Citrobacter
braakii) 		PF00067
(p450) 		4 PHE A 364
PHE A 396
ILE A 394
GLY A 138
 None
 0.94A 4ejjC-3bdzA:
29.8		 4ejjC-3bdzA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djb HYDROLASE, HD FAMILY

(Bacillus
thuringiensis) 		PF01966
(HD) 		4 PHE A 136
PHE A 173
ILE A 132
GLY A 131
 None
 1.00A 4ejjC-3djbA:
undetectable		 4ejjC-3djbA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eur UNCHARACTERIZED
PROTEIN

(Bacteroides
fragilis) 		PF13905
(Thioredoxin_8) 		4 PHE A  11
ILE A  70
GLY A  93
THR A  91
 None
 0.88A 4ejjC-3eurA:
undetectable		 4ejjC-3eurA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis) 		PF12741
(SusD-like) 		4 PHE A 459
PHE A 321
ILE A 305
GLY A 302
 None
 0.94A 4ejjC-3gzsA:
undetectable		 4ejjC-3gzsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2d CHEC-LIKE
SUPERFAMILY PROTEIN

(Shewanella
oneidensis) 		PF13690
(CheX) 		4 PHE A   9
PHE A 111
GLY A  55
THR A  53
 None
 0.89A 4ejjC-3h2dA:
undetectable		 4ejjC-3h2dA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B

(Sulfurisphaera
tokodaii) 		PF00994
(MoCF_biosynth) 		4 PHE A  73
ILE A  23
GLY A  89
THR A  91
 None
 1.02A 4ejjC-3iwtA:
undetectable		 4ejjC-3iwtA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A 648
PHE A 646
GLY A 666
THR A 669
 None
 0.96A 4ejjC-3kn5A:
undetectable		 4ejjC-3kn5A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lx6 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		4 PHE A 434
PHE A 421
ILE A  96
GLY A  97
 None
 0.96A 4ejjC-3lx6A:
undetectable		 4ejjC-3lx6A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		4 PHE A 434
PHE A 421
ILE A  96
GLY A  97
 None
 0.95A 4ejjC-3me5A:
undetectable		 4ejjC-3me5A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myu HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37

(Mycoplasma
genitalium) 		PF06646
(Mycoplasma_p37) 		4 PHE A  36
PHE A  55
ILE A 324
GLY A 325
 None
 0.79A 4ejjC-3myuA:
undetectable		 4ejjC-3myuA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT BETA

(Desulfovibrio
gigas) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 PHE B 305
ILE B 206
GLY B 205
THR B 156
 None
 0.97A 4ejjC-3or2B:
undetectable		 4ejjC-3or2B:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Entamoeba
histolytica) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 PHE A   4
ILE A  37
GLY A  36
THR A  56
 None
 0.99A 4ejjC-3p91A:
undetectable		 4ejjC-3p91A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4d POSSIBLE
CHLOROMUCONATE
CYCLOISOMERASE
MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY

(Cytophaga
hutchinsonii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A  51
PHE A  19
ILE A  21
THR A 135
 ALA  A2473 ( 4.6A)
DAL  A2472 (-4.8A)
ALA  A2473 ( 4.8A)
DAL  A2472 (-3.6A)
 0.68A 4ejjC-3q4dA:
undetectable		 4ejjC-3q4dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcm TATD FAMILY
HYDROLASE

(Pseudomonas
putida) 		PF01026
(TatD_DNase) 		4 PHE A 131
ILE A   6
GLY A   7
THR A  37
 None
 0.81A 4ejjC-3rcmA:
undetectable		 4ejjC-3rcmA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rxy NIF3 PROTEIN

(Sphaerobacter
thermophilus) 		no annotation 4 PHE A 129
ILE A  44
GLY A  45
THR A 118
 None
 1.00A 4ejjC-3rxyA:
undetectable		 4ejjC-3rxyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5p RIBOSE 5-PHOSPHATE
ISOMERASE

(Giardia
intestinalis) 		PF02502
(LacAB_rpiB) 		4 PHE A  45
ILE A  71
GLY A  70
THR A  67
 None
SO4  A 146 (-4.0A)
SO4  A 146 (-3.3A)
SO4  A 146 (-3.9A)
 1.01A 4ejjC-3s5pA:
undetectable		 4ejjC-3s5pA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slc ACETATE KINASE

(Salmonella
enterica) 		PF00871
(Acetate_kinase) 		4 PHE A 354
ILE A 314
GLY A 315
THR A 318
 None
 0.65A 4ejjC-3slcA:
undetectable		 4ejjC-3slcA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1p ALPHA-1-ANTITRYPSIN

(Homo sapiens) 		PF00079
(Serpin) 		4 PHE A  61
PHE A 312
ILE A 308
GLY A 304
 None
 1.01A 4ejjC-3t1pA:
undetectable		 4ejjC-3t1pA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 PHE A 122
PHE A 180
ILE A 193
GLY A 190
THR A 187
 None
 1.35A 4ejjC-3tqiA:
undetectable		 4ejjC-3tqiA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0f ENDONUCLEASE 8-LIKE
3

(Mus musculus) 		PF06831
(H2TH) 		4 PHE A 131
ILE A  14
GLY A  11
THR A  79
 None
 0.83A 4ejjC-3w0fA:
undetectable		 4ejjC-3w0fA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif PENTON PROTEIN

(Bovine
mastadenovirus
B) 		PF01686
(Adeno_Penton_B) 		4 PHE M 260
ILE M 250
GLY M 249
THR M 337
 None
 0.87A 4ejjC-3zifM:
undetectable		 4ejjC-3zifM:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE

(Bacteroides
ovatus) 		PF03414
(Glyco_transf_6) 		4 PHE A  94
PHE A  28
ILE A   5
GLY A   4
 None
 0.85A 4ejjC-4ayjA:
undetectable		 4ejjC-4ayjA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		4 PHE A 385
PHE A 352
ILE A 451
GLY A 452
 None
 0.92A 4ejjC-4db4A:
undetectable		 4ejjC-4db4A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4er8 TNPAREP FOR PROTEIN

(Escherichia
coli) 		no annotation 4 PHE A 157
PHE A  15
GLY A 160
THR A  17
 None
 0.99A 4ejjC-4er8A:
undetectable		 4ejjC-4er8A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eu2 PROTEASOME COMPONENT
C7-ALPHA

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 PHE A 186
ILE A 194
GLY A  47
THR A  51
 None
 0.84A 4ejjC-4eu2A:
undetectable		 4ejjC-4eu2A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 PHE A 403
PHE A 427
ILE A 379
GLY A 382
 None
 1.03A 4ejjC-4f7zA:
undetectable		 4ejjC-4f7zA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		4 PHE A 157
ILE A 280
GLY A 178
THR A 180
 None
 0.82A 4ejjC-4k0eA:
undetectable		 4ejjC-4k0eA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX

(Pseudomonas
aeruginosa) 		no annotation 4 PHE B 324
PHE B 147
GLY B  84
THR B 143
 None
 0.89A 4ejjC-4kncB:
undetectable		 4ejjC-4kncB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 PHE E 403
PHE E 427
ILE E 379
GLY E 382
 None
 1.03A 4ejjC-4mh0E:
undetectable		 4ejjC-4mh0E:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk6 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		4 PHE A 293
PHE A 301
ILE A 281
THR A 239
 None
 0.91A 4ejjC-4nk6A:
undetectable		 4ejjC-4nk6A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozy POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		4 PHE A 293
PHE A 301
ILE A 281
THR A 239
 None
 0.88A 4ejjC-4ozyA:
undetectable		 4ejjC-4ozyA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1

(Homo sapiens) 		PF00899
(ThiF)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 PHE A 275
ILE A 277
GLY A 230
THR A 225
 None
 0.90A 4ejjC-4p22A:
undetectable		 4ejjC-4p22A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p63 PROBABLE
DEOXYHYPUSINE
SYNTHASE

(Pyrococcus
horikoshii) 		PF01916
(DS) 		4 PHE A 176
PHE A 157
ILE A 217
GLY A 218
 None
 0.70A 4ejjC-4p63A:
undetectable		 4ejjC-4p63A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgk UNCHARACTERIZED
PROTEIN

(Yersinia pestis) 		PF07350
(DUF1479) 		4 PHE A 395
PHE A 111
ILE A 137
GLY A 136
 None
 0.88A 4ejjC-4rgkA:
undetectable		 4ejjC-4rgkA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)

(Bacillus
halodurans) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		5 PHE A 527
PHE A 472
ILE A 551
GLY A 560
THR A 465
 None
 1.44A 4ejjC-4v2xA:
undetectable		 4ejjC-4v2xA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wco C-TYPE LECTIN DOMAIN
FAMILY 2 MEMBER D

(Homo sapiens) 		PF00059
(Lectin_C) 		4 PHE A  89
PHE A 121
ILE A  80
GLY A  81
 None
 0.95A 4ejjC-4wcoA:
undetectable		 4ejjC-4wcoA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xx6 BETA-XYLANASE

(Gloeophyllum
trabeum) 		PF00331
(Glyco_hydro_10) 		4 PHE A 328
PHE A  69
ILE A 308
GLY A 307
 None
 1.04A 4ejjC-4xx6A:
undetectable		 4ejjC-4xx6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y6t COAT PROTEIN

(Tobacco streak
virus) 		PF01787
(Ilar_coat) 		4 PHE A 183
PHE A 151
ILE A 141
GLY A 142
 None
 0.80A 4ejjC-4y6tA:
undetectable		 4ejjC-4y6tA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydj HEAVY CHAIN OF
ANTIBODY 44-VRC13.01

(Homo sapiens) 		no annotation 4 PHE H  35
ILE H  35
GLY H  49
THR H  58
 None
 0.79A 4ejjC-4ydjH:
undetectable		 4ejjC-4ydjH:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 PHE A 492
ILE A 217
GLY A 218
THR A 575
 None
 0.89A 4ejjC-4yzwA:
undetectable		 4ejjC-4yzwA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		4 PHE A1046
ILE A 948
GLY A 994
THR A 992
 None
 0.89A 4ejjC-4zhjA:
undetectable		 4ejjC-4zhjA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az4 FLAGELLAR HOOK
SUBUNIT PROTEIN

(Campylobacter
jejuni) 		PF07196
(Flagellin_IN)
PF07559
(FlaE) 		4 PHE A 771
ILE A 165
GLY A 746
THR A 744
 None
 0.83A 4ejjC-5az4A:
undetectable		 4ejjC-5az4A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SHORT-ROOT
ZINC FINGER PROTEIN
JACKDAW

(Arabidopsis
thaliana) 		PF00096
(zf-C2H2)
PF03514
(GRAS) 		4 PHE B 218
PHE C 206
ILE B 311
THR B 267
 None
 1.02A 4ejjC-5b3hB:
undetectable		 4ejjC-5b3hB:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza C
virus) 		PF00603
(Flu_PA) 		4 PHE A 156
PHE A  12
ILE A  40
GLY A  39
 None
 0.93A 4ejjC-5d9aA:
undetectable		 4ejjC-5d9aA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu5 CBM77-RFPL

(Ruminococcus
flavefaciens) 		no annotation 4 PHE A1072
ILE A1084
GLY A1086
THR A1112
 None
 0.95A 4ejjC-5fu5A:
undetectable		 4ejjC-5fu5A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		4 PHE A 234
ILE A 219
GLY A 224
THR A 228
 None
 0.90A 4ejjC-5gu6A:
undetectable		 4ejjC-5gu6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL

(Oryctolagus
cuniculus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 PHE A 254
PHE A 196
ILE A 459
GLY A 460
 None
 0.81A 4ejjC-5h53A:
undetectable		 4ejjC-5h53A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA

(Escherichia
coli) 		PF09481
(CRISPR_Cse1) 		4 PHE A  91
PHE A 233
ILE A  54
GLY A  55
 None
 1.04A 4ejjC-5h9fA:
undetectable		 4ejjC-5h9fA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxz BARBITURASE

(Rhodococcus
erythropolis) 		PF09663
(Amido_AtzD_TrzD) 		4 PHE A  97
PHE A 297
ILE A  39
GLY A  40
 None
 0.92A 4ejjC-5hxzA:
undetectable		 4ejjC-5hxzA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id6 CPF1

(Lachnospiraceae
bacterium
ND2006) 		no annotation 4 PHE A 395
PHE A 389
ILE A 344
GLY A 341
 None
 1.03A 4ejjC-5id6A:
undetectable		 4ejjC-5id6A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihy UNCHARACTERIZED
PROTEIN

(Bacillus
subtilis) 		PF01966
(HD) 		4 PHE A 138
PHE A 159
ILE A 134
GLY A 133
 None
 1.02A 4ejjC-5ihyA:
undetectable		 4ejjC-5ihyA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm0 ALPHA-MANNOSIDASE,AL
PHA-MANNOSIDASE,ALPH
A-MANNOSIDASE

(Saccharomyces
cerevisiae) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 PHE A 389
ILE A 428
GLY A 369
THR A 371
 None
 1.04A 4ejjC-5jm0A:
undetectable		 4ejjC-5jm0A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksw DIHYDROOROTATE
DEHYDROGENASE

(Lactococcus
lactis) 		PF01180
(DHO_dh) 		4 PHE A  29
ILE A  84
GLY A  80
THR A  51
 None
None
None
CL  A 402 (-3.8A)
 1.04A 4ejjC-5kswA:
undetectable		 4ejjC-5kswA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus) 		no annotation 4 PHE A 560
PHE A 722
ILE A 690
GLY A 691
 None
 0.86A 4ejjC-5n2gA:
undetectable		 4ejjC-5n2gA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr9 FERREDOXIN-NADP
REDUCTASE

(Neisseria
gonorrhoeae) 		PF00175
(NAD_binding_1) 		4 PHE A 165
PHE A  80
ILE A 132
GLY A 129
 None
None
None
EDO  A 304 (-3.3A)
 1.01A 4ejjC-5tr9A:
undetectable		 4ejjC-5tr9A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux4 CATHEPSIN D

(Rattus
norvegicus) 		no annotation 4 PHE A 328
ILE A 321
GLY A 317
THR A 229
 None
None
None
3UT  A 404 ( 4.8A)
 1.02A 4ejjC-5ux4A:
undetectable		 4ejjC-5ux4A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v44 SACSIN

(Homo sapiens) 		no annotation 4 PHE A 194
PHE A 271
ILE A 206
THR A 269
 None
 0.91A 4ejjC-5v44A:
undetectable		 4ejjC-5v44A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4a P-GRANULE SCAFFOLD

(Caenorhabditis
japonica) 		no annotation 4 PHE A 197
ILE A  14
GLY A  13
THR A 204
 None
 1.00A 4ejjC-5w4aA:
undetectable		 4ejjC-5w4aA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwp ORF1AB

(Middle East
respiratory
syndrome-related
coronavirus) 		no annotation 4 PHE B 225
ILE B 154
GLY B 222
THR B 220
 None
 1.00A 4ejjC-5wwpB:
undetectable		 4ejjC-5wwpB:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmg UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 PHE A  82
ILE A 221
GLY A  31
THR A 256
 None
 1.01A 4ejjC-5xmgA:
undetectable		 4ejjC-5xmgA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y30 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo sapiens) 		no annotation 4 PHE A  98
PHE A 111
ILE A  82
THR A 134
 None
 0.76A 4ejjC-5y30A:
undetectable		 4ejjC-5y30A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo sapiens) 		no annotation 4 PHE B  98
PHE B 111
ILE B  82
THR B 134
 None
 0.75A 4ejjC-5y31B:
undetectable		 4ejjC-5y31B:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE

(Paracoccus
denitrificans) 		no annotation 4 PHE A 534
ILE A 244
GLY A 247
THR A 236
 None
 0.97A 4ejjC-6es9A:
undetectable		 4ejjC-6es9A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fx4 E3 UBIQUITIN-PROTEIN
LIGASE SMURF2

(Homo sapiens) 		no annotation 4 PHE A  26
PHE A  68
ILE A  90
THR A  46
 None
 1.04A 4ejjC-6fx4A:
undetectable		 4ejjC-6fx4A:
11.78