SIMILAR PATTERNS OF AMINO ACIDS FOR 4EJJ_B_NCTB501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf5 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 PHE A 581
ASN A 515
GLY A 513
THR A 510
 None
 1.00A 4ejjB-1bf5A:
0.2		 4ejjB-1bf5A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		4 PHE C 503
VAL C 300
GLY A  90
PHE C 328
 None
None
HEM  A 605 (-3.5A)
None
 0.78A 4ejjB-1d7wC:
undetectable		 4ejjB-1d7wC:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		4 PHE A  16
VAL A  75
GLY A  19
THR A 170
 None
None
CL  A 385 ( 3.8A)
None
 0.98A 4ejjB-1dgmA:
0.0		 4ejjB-1dgmA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek2 EPOXIDE HYDROLASE

(Mus musculus) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		4 PHE A 385
PHE A 406
THR A 402
PHE A 265
 None
CDU  A1100 (-4.6A)
None
None
 1.00A 4ejjB-1ek2A:
0.0		 4ejjB-1ek2A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewr DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 VAL A 680
PHE A 639
GLY A 665
THR A 668
 None
 1.01A 4ejjB-1ewrA:
0.0		 4ejjB-1ewrA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlm HEMOGLOBIN (CYANO
MET)

(Molpadia
arenicola) 		PF00042
(Globin) 		4 PHE A  53
VAL A 109
PHE A  39
ASN A 113
 HEM  A 159 (-4.4A)
HEM  A 159 (-3.7A)
CYN  A 160 (-4.7A)
HEM  A 159 ( 4.1A)
 0.95A 4ejjB-1hlmA:
undetectable		 4ejjB-1hlmA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		4 ASN A 321
GLY A 252
THR A 183
PHE A 171
 None
 0.92A 4ejjB-1hxjA:
0.0		 4ejjB-1hxjA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 PHE A 208
ASN A 434
GLY A 441
THR A 214
PHE A 825
 None
 1.49A 4ejjB-1kqfA:
0.0		 4ejjB-1kqfA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpp PEPSIN

(Rhizomucor
pusillus) 		PF00026
(Asp) 		4 PHE A 258
PHE A 227
GLY A 196
PHE A 221
 None
 0.99A 4ejjB-1mppA:
0.0		 4ejjB-1mppA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvg DNA TOPOISOMERASE II

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 PHE A 362
ASN A 142
GLY A 140
THR A 138
 None
ANP  A 901 (-4.7A)
ANP  A 901 (-3.4A)
None
 1.00A 4ejjB-1pvgA:
0.0		 4ejjB-1pvgA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r82 GLYCOPROTEIN-FUCOSYL
GALACTOSIDE
ALPHA-GALACTOSYLTRAN
SFERASE

(Homo sapiens) 		PF03414
(Glyco_transf_6) 		4 PHE A 229
VAL A  95
GLY A 221
PHE A 269
 None
 0.92A 4ejjB-1r82A:
undetectable		 4ejjB-1r82A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttx ONCOMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 PHE A  30
VAL A 107
PHE A  71
PHE A  67
 None
 0.97A 4ejjB-1ttxA:
undetectable		 4ejjB-1ttxA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5d PROTEIN
DISULFIDE-ISOMERASE
A6

(Homo sapiens) 		PF00085
(Thioredoxin) 		4 PHE A  17
VAL A  67
ASN A  72
PHE A  90
 None
 0.98A 4ejjB-1x5dA:
undetectable		 4ejjB-1x5dA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc3 PUTATIVE
FRUCTOKINASE

(Bacillus
subtilis) 		PF00480
(ROK) 		4 PHE A  45
VAL A  90
GLY A  54
THR A 280
 None
 1.00A 4ejjB-1xc3A:
undetectable		 4ejjB-1xc3A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9c SULFITE OXIDASE

(Gallus gallus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 VAL A 290
PHE A 136
GLY A 296
PHE A 135
 None
MTE  A1501 (-3.5A)
MTE  A1501 (-3.8A)
MTE  A1501 (-4.7A)
 0.94A 4ejjB-2a9cA:
undetectable		 4ejjB-2a9cA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azp HYPOTHETICAL PROTEIN
PA1268

(Pseudomonas
aeruginosa) 		PF05544
(Pro_racemase) 		4 PHE A 269
VAL A 131
GLY A  94
THR A  16
 None
 0.81A 4ejjB-2azpA:
undetectable		 4ejjB-2azpA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A

(Starkeya
novella) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 VAL A 204
PHE A  53
GLY A 210
PHE A  52
 None
MSS  A1374 (-3.2A)
MSS  A1374 (-3.8A)
None
 0.98A 4ejjB-2ca4A:
undetectable		 4ejjB-2ca4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mus musculus) 		PF00342
(PGI) 		4 PHE A 348
VAL A 167
GLY A 488
PHE A 352
 None
 0.86A 4ejjB-2cxnA:
undetectable		 4ejjB-2cxnA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkh 3-HYDROXYBENZOATE
HYDROXYLASE

(Comamonas
testosteroni) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		4 PHE A 467
VAL A 611
GLY A 490
PHE A 504
 None
 0.75A 4ejjB-2dkhA:
undetectable		 4ejjB-2dkhA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA

(Staphylococcus
aureus) 		PF01039
(Carboxyl_trans) 		4 VAL B 111
GLY B 142
THR B 183
PHE B 159
 None
 0.82A 4ejjB-2f9iB:
undetectable		 4ejjB-2f9iB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fct SYRINGOMYCIN
BIOSYNTHESIS ENZYME
2

(Pseudomonas
syringae) 		PF05721
(PhyH) 		4 PHE A 148
GLY A 224
THR A 146
PHE A  74
 None
 1.01A 4ejjB-2fctA:
undetectable		 4ejjB-2fctA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gd9 HYPOTHETICAL PROTEIN
YYAP

(Bacillus
subtilis) 		PF01872
(RibD_C) 		4 VAL A 161
ASN A 135
GLY A 137
PHE A 142
 None
 0.98A 4ejjB-2gd9A:
undetectable		 4ejjB-2gd9A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjm LACTOPEROXIDASE

(Bubalus bubalis) 		PF03098
(An_peroxidase) 		4 PHE A 503
VAL A 300
GLY A  90
PHE A 328
 None
None
HEM  A 605 (-3.4A)
None
 0.88A 4ejjB-2gjmA:
undetectable		 4ejjB-2gjmA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq6 SEROLOGICALLY
DEFINED COLON CANCER
ANTIGEN 10

(Homo sapiens) 		PF00160
(Pro_isomerase) 		4 PHE A 113
PHE A  54
THR A  19
PHE A 115
 None
 0.97A 4ejjB-2hq6A:
undetectable		 4ejjB-2hq6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 PHE X 525
ASN X 336
GLY X  14
THR X  36
 None
None
SF4  X 800 ( 4.5A)
None
 1.00A 4ejjB-2iv2X:
undetectable		 4ejjB-2iv2X:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nly DIVERGENT
POLYSACCHARIDE
DEACETYLASE
HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF04748
(Polysacc_deac_2) 		4 PHE A  41
PHE A  51
GLY A 219
THR A 228
 None
 0.94A 4ejjB-2nlyA:
undetectable		 4ejjB-2nlyA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq9 ENDONUCLEASE 4

(Escherichia
coli) 		PF01261
(AP_endonuc_2) 		4 VAL A 168
PHE A  91
ASN A 131
PHE A 108
 None
 1.02A 4ejjB-2nq9A:
undetectable		 4ejjB-2nq9A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 VAL A  39
GLY A  14
THR A 372
PHE A 369
 None
 1.02A 4ejjB-2nyaA:
undetectable		 4ejjB-2nyaA:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		6 PHE A 107
VAL A 117
PHE A 209
GLY A 301
THR A 305
PHE A 480
 None
HEM  A 500 (-3.7A)
None
HEM  A 500 ( 4.7A)
HEM  A 500 (-3.6A)
None
 0.37A 4ejjB-2pg6A:
64.3		 4ejjB-2pg6A:
99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 PHE G 771
VAL G1058
PHE G 767
GLY G 734
 None
 0.96A 4ejjB-2uv8G:
undetectable		 4ejjB-2uv8G:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6o THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Schistosoma
mansoni) 		PF00462
(Glutaredoxin)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 PHE A 343
VAL A 291
GLY A 303
THR A 475
 PG4  A1597 (-3.7A)
None
None
None
 1.00A 4ejjB-2v6oA:
undetectable		 4ejjB-2v6oA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		4 VAL A 275
PHE A 356
GLY A 330
THR A 374
 None
 0.92A 4ejjB-3a6pA:
undetectable		 4ejjB-3a6pA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN-TYPE

(Toxoplasma
gondii) 		PF00160
(Pro_isomerase) 		4 PHE A  43
VAL A 166
GLY A  59
PHE A  34
 None
 0.80A 4ejjB-3bo7A:
undetectable		 4ejjB-3bo7A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dgz THIOREDOXIN
REDUCTASE 2

(Mus musculus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 PHE A 242
VAL A 190
GLY A 202
THR A 368
 None
 1.01A 4ejjB-3dgzA:
undetectable		 4ejjB-3dgzA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT ALPHA
BENZENE
1,2-DIOXYGENASE
SUBUNIT BETA

(Pseudomonas
putida) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
PF00866
(Ring_hydroxyl_B) 		4 VAL A 371
PHE B  46
GLY B  90
PHE B 186
 None
 1.02A 4ejjB-3eqqA:
undetectable		 4ejjB-3eqqA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)

(Salmonella
enterica) 		PF09982
(DUF2219) 		4 PHE A 176
VAL A 171
GLY A 200
PHE A  82
 GOL  A 302 (-4.3A)
None
None
None
 0.97A 4ejjB-3fidA:
undetectable		 4ejjB-3fidA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0t PUTATIVE
AMINOTRANSFERASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		4 PHE A 261
VAL A 336
PHE A  93
GLY A 225
 None
 0.85A 4ejjB-3g0tA:
undetectable		 4ejjB-3g0tA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2d CHEC-LIKE
SUPERFAMILY PROTEIN

(Shewanella
oneidensis) 		PF13690
(CheX) 		4 PHE A   9
PHE A 111
GLY A  55
THR A  53
 None
 0.82A 4ejjB-3h2dA:
undetectable		 4ejjB-3h2dA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2z MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Shigella
flexneri) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 VAL A 174
PHE A  29
ASN A  10
GLY A  12
 None
None
ACT  A 383 (-4.8A)
None
 0.96A 4ejjB-3h2zA:
undetectable		 4ejjB-3h2zA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE

(Vibrio cholerae) 		PF00342
(PGI) 		4 PHE A 346
VAL A 166
GLY A 484
PHE A 350
 None
 0.82A 4ejjB-3hjbA:
undetectable		 4ejjB-3hjbA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		4 PHE A  50
GLY A  42
THR A  63
PHE A  98
 None
 0.83A 4ejjB-3hxwA:
undetectable		 4ejjB-3hxwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A 648
PHE A 646
GLY A 666
THR A 669
 None
 0.98A 4ejjB-3kn5A:
undetectable		 4ejjB-3kn5A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 PHE A 842
ASN A 889
GLY A 891
PHE A 797
 None
 0.93A 4ejjB-3lppA:
undetectable		 4ejjB-3lppA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00342
(PGI) 		4 PHE A 345
VAL A 165
GLY A 483
PHE A 349
 None
 0.85A 4ejjB-3nbuA:
undetectable		 4ejjB-3nbuA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oos ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		4 PHE A 269
PHE A  41
GLY A 121
PHE A  45
 None
 0.65A 4ejjB-3oosA:
undetectable		 4ejjB-3oosA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdq 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Clostridium
aminobutyricum) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 PHE A 269
VAL A 291
ASN A 295
GLY A 335
 None
None
None
COA  A 500 ( 4.5A)
 0.99A 4ejjB-3qdqA:
undetectable		 4ejjB-3qdqA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r18 SULFITE OXIDASE

(Gallus gallus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 VAL A 290
PHE A 136
GLY A 296
PHE A 135
 None
MTE  A 501 (-3.3A)
MTE  A 501 (-3.8A)
MTE  A 501 (-4.7A)
 0.94A 4ejjB-3r18A:
undetectable		 4ejjB-3r18A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 PHE A 614
VAL A 670
GLY A 598
PHE A 657
 None
 1.00A 4ejjB-3syjA:
undetectable		 4ejjB-3syjA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Bos taurus) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase) 		4 PHE A 759
ASN A 795
GLY A 800
THR A 804
 None
CA  A1003 (-3.7A)
None
None
 1.01A 4ejjB-3tlmA:
undetectable		 4ejjB-3tlmA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue1 PENICILLIN-BINDING
PROTEIN 1A

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		5 VAL A  50
PHE A  63
ASN A 146
GLY A 156
PHE A  59
 None
 1.45A 4ejjB-3ue1A:
undetectable		 4ejjB-3ue1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3utn THIOSULFATE
SULFURTRANSFERASE
TUM1

(Saccharomyces
cerevisiae) 		PF00581
(Rhodanese) 		4 PHE X  56
VAL X  95
PHE X  78
GLY X 112
 None
 0.98A 4ejjB-3utnX:
undetectable		 4ejjB-3utnX:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcu B1 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN

(Lamellibrachia
satsuma) 		PF00042
(Globin) 		5 PHE D  41
VAL D 116
PHE D  64
GLY D  33
THR D  68
 None
 1.34A 4ejjB-3wcuD:
undetectable		 4ejjB-3wcuD:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		4 PHE A 286
VAL A 274
GLY A  27
PHE A 293
 None
 0.99A 4ejjB-4a0hA:
undetectable		 4ejjB-4a0hA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6j PHOSPHOSERINE
PHOSPHATASE

(Thermococcus
onnurineus) 		PF12710
(HAD) 		4 PHE A  64
PHE A  98
GLY A 126
PHE A  18
 None
 1.00A 4ejjB-4b6jA:
undetectable		 4ejjB-4b6jA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqa UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF08522
(DUF1735)
PF13385
(Laminin_G_3) 		4 VAL A 177
PHE A 281
GLY A 207
PHE A 185
 None
 0.97A 4ejjB-4dqaA:
undetectable		 4ejjB-4dqaA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqv INVERTASE 2

(Saccharomyces
cerevisiae) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 PHE A 192
PHE A 241
ASN A 194
GLY A 196
 None
 0.92A 4ejjB-4eqvA:
undetectable		 4ejjB-4eqvA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4er8 TNPAREP FOR PROTEIN

(Escherichia
coli) 		no annotation 4 PHE A 157
PHE A  15
GLY A 160
THR A  17
 None
 0.87A 4ejjB-4er8A:
undetectable		 4ejjB-4er8A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		4 PHE A 362
ASN A 142
GLY A 140
THR A 138
 None
ANP  A1202 (-4.6A)
ANP  A1202 (-2.9A)
None
 0.98A 4ejjB-4gfhA:
undetectable		 4ejjB-4gfhA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 VAL A 925
PHE A 912
GLY A 931
PHE A 975
 None
 0.99A 4ejjB-4iugA:
undetectable		 4ejjB-4iugA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j57 THIOREDOXIN
REDUCTASE 2

(Plasmodium
falciparum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 PHE A 279
VAL A 227
GLY A 239
THR A 399
 None
 0.99A 4ejjB-4j57A:
undetectable		 4ejjB-4j57A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9w PROLINE RACEMASE
FAMILY PROTEIN

(Pseudomonas
protegens) 		PF05544
(Pro_racemase) 		4 PHE A 269
VAL A 131
GLY A  94
THR A  16
 GOL  A 404 (-4.7A)
None
None
None
 0.88A 4ejjB-4j9wA:
undetectable		 4ejjB-4j9wA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k8l PROLINE RACEMASE

(Ochrobactrum
anthropi) 		PF05544
(Pro_racemase) 		4 PHE A 174
GLY A 171
THR A 257
PHE A 223
 None
 0.92A 4ejjB-4k8lA:
undetectable		 4ejjB-4k8lA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX

(Pseudomonas
aeruginosa) 		no annotation 4 PHE B 324
PHE B 147
GLY B  84
THR B 143
 None
 0.96A 4ejjB-4kncB:
undetectable		 4ejjB-4kncB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpr THIOREDOXIN
REDUCTASE 1,
CYTOPLASMIC

(Rattus
norvegicus) 		no annotation 4 PHE E 247
VAL E 195
GLY E 207
THR E 376
 MPD  E 503 ( 4.1A)
None
None
None
 1.00A 4ejjB-4kprE:
undetectable		 4ejjB-4kprE:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8n PDZ DOMAIN PROTEIN

(Parabacteroides
distasonis) 		PF00595
(PDZ)
PF13590
(DUF4136) 		4 VAL A 301
PHE A 167
THR A 192
PHE A 169
 None
 1.01A 4ejjB-4l8nA:
undetectable		 4ejjB-4l8nA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CWC27 HOMOLOG

(Homo sapiens) 		PF00160
(Pro_isomerase) 		4 PHE A 113
PHE A  54
THR A  19
PHE A 115
 None
 0.97A 4ejjB-4r3eA:
undetectable		 4ejjB-4r3eA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		4 PHE A 368
VAL A 332
ASN A 342
GLY A 399
 TRS  A 802 (-3.8A)
None
None
None
 0.94A 4ejjB-4rhhA:
undetectable		 4ejjB-4rhhA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnr PGT130 HEAVY CHAIN
PGT130 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE B  98
PHE A 100
ASN A  60
GLY A  49
 None
 1.02A 4ejjB-4rnrB:
undetectable		 4ejjB-4rnrB:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkx LYS-GINGIPAIN W83

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		5 VAL L 364
PHE L 307
GLY L 591
THR L 552
PHE L 268
 None
 1.47A 4ejjB-4tkxL:
undetectable		 4ejjB-4tkxL:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzu ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 PHE A 104
ASN A 215
GLY A 217
PHE A 241
 None
 0.97A 4ejjB-4uzuA:
undetectable		 4ejjB-4uzuA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE

(Colias
eurytheme) 		PF00342
(PGI) 		4 PHE A 351
VAL A 171
GLY A 491
PHE A 355
 None
 0.82A 4ejjB-4wmjA:
undetectable		 4ejjB-4wmjA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xt8 RV2671

(Mycobacterium
tuberculosis) 		PF01872
(RibD_C) 		4 VAL A  85
GLY A 124
THR A 152
PHE A 133
 NAP  A 301 (-4.3A)
None
None
None
 0.99A 4ejjB-4xt8A:
undetectable		 4ejjB-4xt8A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE

(Homo sapiens) 		PF03414
(Glyco_transf_6) 		4 PHE A 229
VAL A  95
GLY A 221
PHE A 269
 None
 0.93A 4ejjB-4y63A:
undetectable		 4ejjB-4y63A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 VAL A 178
PHE A 166
GLY A 170
PHE A 134
 None
 1.00A 4ejjB-4ztxA:
undetectable		 4ejjB-4ztxA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 PHE A 323
VAL A 293
PHE A 137
GLY A 114
 None
ST9  A 403 (-4.8A)
None
None
 0.78A 4ejjB-4zyoA:
undetectable		 4ejjB-4zyoA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		4 PHE A 240
VAL A 187
GLY A 184
PHE A 199
 None
 1.01A 4ejjB-5a42A:
undetectable		 4ejjB-5a42A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by7 3-OXOACYL-ACP
SYNTHASE III

(Verrucosispora
maris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 VAL A  19
ASN A   2
GLY A   6
PHE A 152
 None
 0.92A 4ejjB-5by7A:
undetectable		 4ejjB-5by7A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlj CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Escherichia
coli) 		no annotation 4 PHE D 120
VAL D 207
GLY D 139
PHE D 124
 None
 0.95A 4ejjB-5dljD:
undetectable		 4ejjB-5dljD:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1

(Homo sapiens) 		PF00083
(Sugar_tr) 		4 PHE A  72
PHE A  26
GLY A 134
THR A 137
 None
None
None
5RH  A 501 (-2.9A)
 1.01A 4ejjB-5eqiA:
undetectable		 4ejjB-5eqiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f84 COAGULATION FACTOR
IX
O-GLUCOSYLTRANSFERAS
E RUMI

(Drosophila
melanogaster;
Homo sapiens) 		PF00008
(EGF)
PF05686
(Glyco_transf_90) 		4 ASN B  54
GLY A 190
THR A 185
PHE A 278
 None
None
None
UDP  A 501 ( 3.3A)
 0.91A 4ejjB-5f84B:
undetectable		 4ejjB-5f84B:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn1 COAT PROTEIN

(Pepino mosaic
virus) 		PF00286
(Flexi_CP) 		4 PHE A 126
GLY A  62
THR A  75
PHE A 130
 None
 0.94A 4ejjB-5fn1A:
undetectable		 4ejjB-5fn1A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftf TPR DOMAIN PROTEIN

(Bacteroides sp.
3_1_23) 		PF05970
(PIF1) 		4 ASN A  61
GLY A  63
THR A 330
PHE A 264
 None
 1.02A 4ejjB-5ftfA:
undetectable		 4ejjB-5ftfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL

(Oryctolagus
cuniculus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 PHE A 254
PHE A 196
ASN A 172
GLY A 460
 None
 0.97A 4ejjB-5h53A:
undetectable		 4ejjB-5h53A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijb TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF00560
(LRR_1)
PF11921
(DUF3439)
PF13855
(LRR_8) 		4 PHE A 121
PHE A 116
THR A 135
PHE A 143
 None
 0.93A 4ejjB-5ijbA:
undetectable		 4ejjB-5ijbA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		4 VAL A  39
GLY A 200
THR A 174
PHE A  12
 None
 0.99A 4ejjB-5j44A:
undetectable		 4ejjB-5j44A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6b ALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		4 PHE A  80
ASN A  96
GLY A 100
THR A 103
 None
 0.72A 4ejjB-5j6bA:
undetectable		 4ejjB-5j6bA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlv SYNAPTIC VESICLE
GLYCOPROTEIN 2C

(Homo sapiens) 		PF13599
(Pentapeptide_4) 		4 PHE C 522
VAL C 505
PHE C 517
PHE C 532
 None
 0.97A 4ejjB-5jlvC:
undetectable		 4ejjB-5jlvC:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		4 PHE A  80
ASN A  96
GLY A 100
THR A 103
 None
 0.66A 4ejjB-5jryA:
undetectable		 4ejjB-5jryA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		4 PHE A 669
VAL A 466
GLY A 256
PHE A 494
 None
None
HEM  A 812 (-3.3A)
None
 0.75A 4ejjB-5mfaA:
undetectable		 4ejjB-5mfaA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svd NUCLEOLAR PROTEIN 9

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		4 VAL A 389
PHE A 338
GLY A 348
PHE A 325
 VAL  A 389 ( 0.6A)
PHE  A 338 ( 1.3A)
GLY  A 348 ( 0.0A)
PHE  A 325 ( 1.3A)
 0.94A 4ejjB-5svdA:
undetectable		 4ejjB-5svdA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc5 CHS2 CHALCONE
SYNTHASE

(Malus domestica) 		no annotation 4 VAL A 271
PHE A 215
GLY A 305
PHE A 265
 None
 0.93A 4ejjB-5uc5A:
undetectable		 4ejjB-5uc5A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufv GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN

(Thermothelomyces
thermophila) 		PF03443
(Glyco_hydro_61) 		4 VAL A 177
PHE A 225
GLY A 145
PHE A 102
 None
 0.95A 4ejjB-5ufvA:
undetectable		 4ejjB-5ufvA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxv SENSORY TRANSDUCTION
REGULATORY PROTEIN

(Bartonella
quintana) 		no annotation 4 PHE A 235
VAL A 104
PHE A 256
THR A  92
 None
 0.99A 4ejjB-5uxvA:
undetectable		 4ejjB-5uxvA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1d PROTOCADHERIN-15

(Mus musculus) 		no annotation 4 PHE A 458
ASN A 475
GLY A 381
PHE A 431
 None
 0.91A 4ejjB-5w1dA:
undetectable		 4ejjB-5w1dA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxl RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae) 		PF04427
(Brix) 		4 PHE A 201
VAL A 118
PHE A 165
PHE A 161
 None
 1.01A 4ejjB-5wxlA:
undetectable		 4ejjB-5wxlA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 4 PHE A 669
VAL A 466
GLY A 256
PHE A 494
 None
 0.78A 4ejjB-6azpA:
undetectable		 4ejjB-6azpA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnk IGG1 HEAVY CHAIN
IGG1 KAPPA LIGHT
CHAIN

(Mus musculus) 		no annotation 4 PHE F 103
ASN G  62
GLY G  50
PHE F  94
 None
 1.00A 4ejjB-6cnkF:
undetectable		 4ejjB-6cnkF:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6y APRA
METHYLTRANSFERASE 2

(Moorea
bouillonii) 		no annotation 4 PHE A 793
VAL A 762
GLY A 952
PHE A 797
 None
 0.79A 4ejjB-6d6yA:
undetectable		 4ejjB-6d6yA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es1 SYNAPTIC VESICLE
GLYCOPROTEIN 2C

(Homo sapiens) 		no annotation 4 PHE B 522
VAL B 505
PHE B 517
PHE B 532
 None
 0.98A 4ejjB-6es1B:
undetectable		 4ejjB-6es1B:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es1 SYNAPTIC VESICLE
GLYCOPROTEIN 2C

(Homo sapiens) 		no annotation 4 PHE B 542
VAL B 525
PHE B 537
PHE B 552
 None
 0.98A 4ejjB-6es1B:
undetectable		 4ejjB-6es1B:
10.06