SIMILAR PATTERNS OF AMINO ACIDS FOR 4EJJ_A_NCTA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE

(Trypanosoma
brucei) 		PF00162
(PGK) 		4 PHE A 167
GLY A 375
ILE A 372
PHE A 200
 None
ADP  A 421 (-3.3A)
None
None
 0.80A 4ejjA-13pkA:
0.0		 4ejjA-13pkA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ako EXONUCLEASE III

(Escherichia
coli) 		PF03372
(Exo_endo_phos) 		5 PHE A 110
ASN A   7
GLY A 150
ILE A  91
PHE A 128
 None
 1.41A 4ejjA-1akoA:
0.0		 4ejjA-1akoA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf5 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		5 PHE A 581
ASN A 515
GLY A 513
ILE A 565
PHE A 603
 None
 1.25A 4ejjA-1bf5A:
0.0		 4ejjA-1bf5A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf5 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		5 PHE A 581
ASN A 515
GLY A 513
THR A 510
ILE A 565
 None
 1.23A 4ejjA-1bf5A:
0.0		 4ejjA-1bf5A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjl PROCATHEPSIN L

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 PHE A 143
ASN A  76
GLY A 164
ILE A 211
 None
 0.90A 4ejjA-1cjlA:
0.0		 4ejjA-1cjlA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f82 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 PHE A  25
ASN A 178
GLY A 175
ILE A 172
 None
 0.78A 4ejjA-1f82A:
0.0		 4ejjA-1f82A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8f BENZYL ALCOHOL
DEHYDROGENASE

(Acinetobacter
calcoaceticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A  64
THR A  41
ILE A 370
PHE A 348
 None
 0.68A 4ejjA-1f8fA:
0.0		 4ejjA-1f8fA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvz KALLIKREIN-1E2

(Equus caballus) 		PF00089
(Trypsin) 		5 PHE A 228
GLY A 197
THR A 213
ILE A 190
PHE A 223
 None
 1.20A 4ejjA-1gvzA:
undetectable		 4ejjA-1gvzA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))

(Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10) 		4 ASN L  68
GLY L  70
THR L  74
ILE L   9
 None
SF4  L 423 (-3.9A)
CYS  L 432 (-3.3A)
None
 0.88A 4ejjA-1hfeL:
undetectable		 4ejjA-1hfeL:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igo FAMILY 11 XYLANASE

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11) 		4 PHE A  54
GLY A  51
THR A 178
ILE A  66
 None
 0.91A 4ejjA-1igoA:
0.0		 4ejjA-1igoA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		5 PHE A 124
ASN A 171
GLY A 169
THR A 122
ILE A 148
 None
 1.42A 4ejjA-1k32A:
undetectable		 4ejjA-1k32A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 PHE A 566
ASN A 466
GLY A 464
ILE A 461
PHE A 495
 None
 1.13A 4ejjA-1k72A:
undetectable		 4ejjA-1k72A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 PHE A 208
ASN A 434
GLY A 441
THR A 214
PHE A 825
 None
 1.48A 4ejjA-1kqfA:
undetectable		 4ejjA-1kqfA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krh BENZOATE
1,2-DIOXYGENASE
REDUCTASE

(Acinetobacter
sp.) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 PHE A 171
PHE A 197
GLY A 111
ILE A 137
PHE A 160
 None
 1.43A 4ejjA-1krhA:
undetectable		 4ejjA-1krhA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lv7 FTSH

(Escherichia
coli) 		PF00004
(AAA) 		4 PHE A 288
GLY A 190
ILE A 251
PHE A 240
 None
 0.85A 4ejjA-1lv7A:
undetectable		 4ejjA-1lv7A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m72 CASPASE-1

(Spodoptera
frugiperda) 		PF00656
(Peptidase_C14) 		4 PHE A 173
PHE A 158
THR A 118
ILE A 115
 None
 0.78A 4ejjA-1m72A:
undetectable		 4ejjA-1m72A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rro RAT ONCOMODULIN

(Rattus rattus) 		PF13499
(EF-hand_7) 		4 PHE A  29
PHE A  70
ILE A  50
PHE A  66
 None
 0.87A 4ejjA-1rroA:
undetectable		 4ejjA-1rroA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 PHE A 527
GLY A 136
ILE A 438
PHE A  95
 None
 0.90A 4ejjA-1tmoA:
undetectable		 4ejjA-1tmoA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttx ONCOMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 PHE A  30
PHE A  71
ILE A  51
PHE A  67
 None
 0.82A 4ejjA-1ttxA:
undetectable		 4ejjA-1ttxA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vli SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
SPSE

(Bacillus
subtilis) 		PF03102
(NeuB)
PF08666
(SAF) 		4 GLY A 358
THR A 308
ILE A 312
PHE A 318
 None
 0.80A 4ejjA-1vliA:
undetectable		 4ejjA-1vliA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x42 HYPOTHETICAL PROTEIN
PH0459

(Pyrococcus
horikoshii) 		PF13419
(HAD_2) 		4 ASN A 181
GLY A 179
ILE A 121
PHE A 161
 None
 0.73A 4ejjA-1x42A:
undetectable		 4ejjA-1x42A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN

(Legionella
pneumophila) 		PF01369
(Sec7) 		5 PHE A 288
ASN A 143
THR A 256
ILE A 107
PHE A 196
 None
 1.32A 4ejjA-1xszA:
undetectable		 4ejjA-1xszA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int) 		5 PHE A 581
ASN A 515
GLY A 513
ILE A 565
PHE A 603
 None
 1.19A 4ejjA-1yvlA:
undetectable		 4ejjA-1yvlA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int) 		5 PHE A 581
ASN A 515
GLY A 513
THR A 510
ILE A 565
 None
 1.25A 4ejjA-1yvlA:
undetectable		 4ejjA-1yvlA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa1 HEMOGLOBIN BETA-C
CHAIN

(Trematomus
newnesi) 		PF00042
(Globin) 		4 PHE B  15
GLY B  70
ILE B  81
PHE B 133
 None
HEM  B 400 ( 4.3A)
None
None
 0.87A 4ejjA-2aa1B:
undetectable		 4ejjA-2aa1B:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 PHE A  95
ASN A  75
ILE A 114
PHE A 116
 None
NAG  A1092 (-3.1A)
None
None
 0.84A 4ejjA-2bucA:
undetectable		 4ejjA-2bucA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djk PROTEIN
DISULFIDE-ISOMERASE

(Humicola
insolens) 		PF13848
(Thioredoxin_6) 		4 PHE A  82
ASN A  56
GLY A  58
ILE A  47
 None
 0.89A 4ejjA-2djkA:
undetectable		 4ejjA-2djkA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes) 		PF02384
(N6_Mtase) 		4 PHE A 241
PHE A 328
GLY A 269
ILE A 324
 None
GOL  A 401 (-4.9A)
None
None
 0.81A 4ejjA-2f8lA:
undetectable		 4ejjA-2f8lA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq6 SEROLOGICALLY
DEFINED COLON CANCER
ANTIGEN 10

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 PHE A 113
PHE A  54
THR A  19
ILE A  24
PHE A 115
 None
 1.15A 4ejjA-2hq6A:
undetectable		 4ejjA-2hq6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ido DNA POLYMERASE III
EPSILON SUBUNIT

(Escherichia
coli) 		PF00929
(RNase_T) 		5 PHE A  79
PHE A 111
THR A 121
ILE A  90
PHE A  86
 None
 1.29A 4ejjA-2idoA:
undetectable		 4ejjA-2idoA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn3 CASPASE-1

(Spodoptera
frugiperda) 		PF00656
(Peptidase_C14) 		4 PHE C 173
PHE C 158
THR C 118
ILE C 115
 None
 0.91A 4ejjA-2nn3C:
undetectable		 4ejjA-2nn3C:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pal PARVALBUMIN

(Esox lucius) 		PF13499
(EF-hand_7) 		4 PHE A  29
PHE A  70
ILE A  50
PHE A  66
 None
 0.87A 4ejjA-2palA:
undetectable		 4ejjA-2palA:
11.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		6 PHE A 107
PHE A 209
GLY A 301
THR A 305
ILE A 366
PHE A 480
 None
None
HEM  A 500 ( 4.7A)
HEM  A 500 (-3.6A)
HEM  A 500 ( 4.1A)
None
 0.41A 4ejjA-2pg6A:
64.2		 4ejjA-2pg6A:
99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		4 PHE A 210
GLY A  39
THR A  45
ILE A 239
 None
 0.92A 4ejjA-2pqdA:
undetectable		 4ejjA-2pqdA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		4 PHE A 488
PHE A 371
GLY A 172
ILE A 411
 None
 0.73A 4ejjA-2qzpA:
undetectable		 4ejjA-2qzpA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wag LYSOZYME, PUTATIVE

(Bacillus
anthracis) 		PF01183
(Glyco_hydro_25) 		5 PHE A  40
PHE A 182
THR A 181
ILE A 142
PHE A  42
 None
None
GOL  A1225 (-3.0A)
None
None
 1.49A 4ejjA-2wagA:
undetectable		 4ejjA-2wagA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		5 PHE A 664
PHE A 662
THR A 654
ILE A 689
PHE A 691
 None
 1.49A 4ejjA-2yocA:
undetectable		 4ejjA-2yocA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		4 PHE A 301
THR A 242
ILE A 239
PHE A 296
 None
 0.84A 4ejjA-2zwaA:
undetectable		 4ejjA-2zwaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 PHE A 143
ASN A 374
GLY A 372
ILE A  75
 None
 0.91A 4ejjA-3ai7A:
undetectable		 4ejjA-3ai7A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5o UPF0311 PROTEIN
RPA1785

(Rhodopseudomonas
palustris) 		PF11578
(DUF3237) 		5 PHE A 119
PHE A  74
THR A  76
ILE A  46
PHE A  11
 None
 1.23A 4ejjA-3c5oA:
undetectable		 4ejjA-3c5oA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce9 GLYCEROL
DEHYDROGENASE

(Clostridium
acetobutylicum) 		PF13685
(Fe-ADH_2) 		4 PHE A 126
ASN A 123
GLY A 168
ILE A 157
 None
 0.85A 4ejjA-3ce9A:
undetectable		 4ejjA-3ce9A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d46 PUTATIVE GALACTONATE
DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASN A 135
GLY A 307
THR A 311
ILE A 315
PHE A 288
 None
 1.28A 4ejjA-3d46A:
undetectable		 4ejjA-3d46A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d46 PUTATIVE GALACTONATE
DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A 389
GLY A 308
THR A 310
ILE A 112
 None
 0.79A 4ejjA-3d46A:
undetectable		 4ejjA-3d46A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ey5 ACETYLTRANSFERASE-LI
KE, GNAT FAMILY

(Bacteroides
thetaiotaomicron) 		PF00583
(Acetyltransf_1) 		4 PHE A  76
GLY A  88
THR A  78
ILE A  52
 None
 0.88A 4ejjA-3ey5A:
undetectable		 4ejjA-3ey5A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 PHE A 260
THR A 179
ILE A 269
PHE A 228
 None
 0.82A 4ejjA-3fefA:
undetectable		 4ejjA-3fefA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 GLY A 337
THR A 339
ILE A 424
PHE A 429
 None
 0.84A 4ejjA-3gcwA:
undetectable		 4ejjA-3gcwA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggr CELL CYCLE
CHECKPOINT CONTROL
PROTEIN RAD9A

(Homo sapiens) 		PF04139
(Rad9) 		5 PHE A 249
PHE A 217
GLY A 169
THR A 167
PHE A 222
 None
 1.50A 4ejjA-3ggrA:
undetectable		 4ejjA-3ggrA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2d CHEC-LIKE
SUPERFAMILY PROTEIN

(Shewanella
oneidensis) 		PF13690
(CheX) 		4 PHE A   9
PHE A 111
GLY A  55
THR A  53
 None
 0.84A 4ejjA-3h2dA:
undetectable		 4ejjA-3h2dA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		4 PHE A  50
GLY A  42
THR A  63
PHE A  98
 None
 0.84A 4ejjA-3hxwA:
undetectable		 4ejjA-3hxwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1a SPECTINOMYCIN
PHOSPHOTRANSFERASE

(Legionella
pneumophila) 		PF01636
(APH) 		4 PHE A 177
PHE A 317
ILE A 289
PHE A 313
 None
 0.91A 4ejjA-3i1aA:
undetectable		 4ejjA-3i1aA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibg ATPASE, SUBUNIT OF
THE GET COMPLEX

(Aspergillus
fumigatus) 		PF02374
(ArsA_ATPase) 		4 PHE A 168
PHE A  30
THR A 236
ILE A 264
 None
 0.92A 4ejjA-3ibgA:
undetectable		 4ejjA-3ibgA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		4 PHE T 116
GLY T 155
ILE T 188
PHE T 128
 None
 0.84A 4ejjA-3icqT:
undetectable		 4ejjA-3icqT:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		5 PHE A 101
PHE A 139
GLY A 116
ILE A 134
PHE A  72
 None
 1.47A 4ejjA-3kl9A:
undetectable		 4ejjA-3kl9A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 PHE A 842
ASN A 889
GLY A 891
PHE A 797
 None
 0.87A 4ejjA-3lppA:
undetectable		 4ejjA-3lppA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN

(Sinorhizobium
meliloti) 		PF01557
(FAA_hydrolase) 		4 PHE A 120
GLY A 115
ILE A 259
PHE A 196
 None
 0.87A 4ejjA-3lzkA:
undetectable		 4ejjA-3lzkA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3meb ASPARTATE
AMINOTRANSFERASE

(Giardia
intestinalis) 		PF00155
(Aminotran_1_2) 		4 PHE A 218
GLY A 107
ILE A 140
PHE A 115
 None
SO4  A 500 ( 3.2A)
None
None
 0.92A 4ejjA-3mebA:
undetectable		 4ejjA-3mebA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7k BOTULINUM NEUROTOXIN
TYPE C1

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 PHE A 938
ASN A1015
ILE A1040
PHE A1042
 None
 0.80A 4ejjA-3n7kA:
undetectable		 4ejjA-3n7kA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nkg UNCHARACTERIZED
PROTEIN
GEBA250068378

(Sulfurospirillum
deleyianum) 		no annotation 5 PHE A  35
ASN A 123
GLY A 122
THR A 120
ILE A 132
 None
ACY  A 175 (-3.1A)
None
None
None
 1.45A 4ejjA-3nkgA:
undetectable		 4ejjA-3nkgA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Trypanosoma
brucei) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 PHE A 531
ASN A 365
GLY A  82
THR A 528
 None
 0.88A 4ejjA-3nvlA:
undetectable		 4ejjA-3nvlA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		4 PHE A 129
ASN A 148
GLY A 146
ILE A 159
 None
 0.85A 4ejjA-3ob8A:
undetectable		 4ejjA-3ob8A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oos ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		4 PHE A 269
PHE A  41
GLY A 121
PHE A  45
 None
 0.69A 4ejjA-3oosA:
undetectable		 4ejjA-3oosA:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		4 ASN A 228
GLY A 232
ILE A 399
PHE A 134
 BHF  A 800 (-4.2A)
None
HEM  A 900 (-4.0A)
BHF  A 800 (-4.8A)
 0.79A 4ejjA-3pm0A:
41.3		 4ejjA-3pm0A:
32.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q94 FRUCTOSE-BISPHOSPHAT
E ALDOLASE, CLASS II

(Bacillus
anthracis) 		PF01116
(F_bP_aldolase) 		4 PHE A  23
PHE A 279
ASN A 233
GLY A 211
 None
None
13P  A 321 (-4.9A)
13P  A 321 (-3.9A)
 0.91A 4ejjA-3q94A:
undetectable		 4ejjA-3q94A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s83 GGDEF FAMILY PROTEIN

(Caulobacter
vibrioides) 		PF00563
(EAL) 		4 ASN A 384
GLY A 355
ILE A 304
PHE A 341
 K  A 549 (-3.3A)
None
None
None
 0.92A 4ejjA-3s83A:
undetectable		 4ejjA-3s83A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue1 PENICILLIN-BINDING
PROTEIN 1A

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		4 PHE A  63
ASN A 146
ILE A 180
PHE A  59
 None
 0.86A 4ejjA-3ue1A:
undetectable		 4ejjA-3ue1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A 120
GLY A  90
THR A 128
ILE A 148
 None
 0.86A 4ejjA-3v9eA:
undetectable		 4ejjA-3v9eA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 PHE A 801
ASN A 194
THR A 749
ILE A 746
PHE A 804
 None
 1.47A 4ejjA-3w9hA:
undetectable		 4ejjA-3w9hA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A

(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 PHE A 315
GLY A 217
ILE A 278
PHE A 267
 PHE  A 315 ( 1.3A)
GLY  A 217 ( 0.0A)
ILE  A 278 ( 0.7A)
PHE  A 267 ( 1.3A)
 0.81A 4ejjA-3whlA:
undetectable		 4ejjA-3whlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x3y PHENYLETHYLAMINE
OXIDASE

(Arthrobacter
globiformis) 		PF01179
(Cu_amine_oxid)
PF02728
(Cu_amine_oxidN3) 		4 PHE A 249
ASN A 309
GLY A 341
ILE A 328
 None
 0.88A 4ejjA-3x3yA:
undetectable		 4ejjA-3x3yA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 PHE A 573
GLY A 383
ILE A 440
PHE A 453
 None
 0.89A 4ejjA-3zu0A:
undetectable		 4ejjA-3zu0A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aib ORNITHINE
DECARBOXYLASE

(Entamoeba
histolytica) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 PHE A 226
GLY A 223
ILE A 239
PHE A 235
 None
 0.85A 4ejjA-4aibA:
undetectable		 4ejjA-4aibA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ASN A 419
GLY A 128
ILE A 405
PHE A 407
 None
 0.92A 4ejjA-4c7vA:
undetectable		 4ejjA-4c7vA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw4 BETA-KETOACYL
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 PHE A 617
ASN A 264
GLY A 269
ILE A 600
 None
 0.90A 4ejjA-4cw4A:
undetectable		 4ejjA-4cw4A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep0 MAJOR TAIL PROTEIN

(Streptococcus
virus C1) 		PF16838
(Caud_tail_N) 		4 PHE A 168
ASN A 280
ILE A 346
PHE A 246
 None
 0.85A 4ejjA-4ep0A:
undetectable		 4ejjA-4ep0A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqv INVERTASE 2

(Saccharomyces
cerevisiae) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 PHE A 192
PHE A 241
ASN A 194
GLY A 196
 None
 0.92A 4ejjA-4eqvA:
undetectable		 4ejjA-4eqvA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4er8 TNPAREP FOR PROTEIN

(Escherichia
coli) 		no annotation 4 PHE A 157
PHE A  15
GLY A 160
THR A  17
 None
 0.87A 4ejjA-4er8A:
undetectable		 4ejjA-4er8A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esa HEMOGLOBIN BETA
CHAIN

(Eleginops
maclovinus) 		PF00042
(Globin) 		4 PHE B  15
GLY B  70
ILE B  81
PHE B 133
 None
HEM  B 202 ( 4.2A)
None
None
 0.83A 4ejjA-4esaB:
undetectable		 4ejjA-4esaB:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
caccae) 		PF07523
(Big_3)
PF13306
(LRR_5) 		4 PHE A 369
GLY A 342
ILE A 334
PHE A 332
 None
 0.81A 4ejjA-4fd0A:
undetectable		 4ejjA-4fd0A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF07523
(Big_3)
PF13306
(LRR_5) 		4 PHE A 369
GLY A 342
ILE A 334
PHE A 332
 None
 0.86A 4ejjA-4fdwA:
undetectable		 4ejjA-4fdwA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fem OUTER MEMBRANE
PROTEIN SUSE

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE) 		5 PHE A 222
ASN A 252
GLY A 231
ILE A 278
PHE A 263
 None
ACX  A 401 (-3.1A)
None
None
None
 1.39A 4ejjA-4femA:
undetectable		 4ejjA-4femA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fvv NEUROTOXIN

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 PHE A 934
ASN A1011
ILE A1036
PHE A1038
 None
 0.81A 4ejjA-4fvvA:
undetectable		 4ejjA-4fvvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g19 GLUTATHIONE
TRANSFERASE GTE1

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		4 PHE A 149
ASN A  24
THR A 137
ILE A 134
 None
GSH  A 302 ( 3.8A)
None
None
 0.89A 4ejjA-4g19A:
undetectable		 4ejjA-4g19A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnn DIHYDRODIPICOLINATE
SYNTHASE

(Vitis vinifera) 		PF00701
(DHDPS) 		4 PHE A 295
THR A 226
ILE A 230
PHE A 307
 None
 0.87A 4ejjA-4hnnA:
undetectable		 4ejjA-4hnnA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594

(Pyrococcus
horikoshii) 		PF00326
(Peptidase_S9)
PF07676
(PD40) 		4 PHE B 596
GLY B 464
ILE B 381
PHE B 600
 None
 0.75A 4ejjA-4hxeB:
undetectable		 4ejjA-4hxeB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iop KILLER CELL
LECTIN-LIKE RECEPTOR
SUBFAMILY F MEMBER 2

(Homo sapiens) 		PF00059
(Lectin_C) 		4 ASN B 127
GLY B 177
ILE B 192
PHE B  92
 None
 0.77A 4ejjA-4iopB:
undetectable		 4ejjA-4iopB:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 PHE A 124
GLY A  98
ILE A 134
PHE A 136
 None
 0.85A 4ejjA-4kcdA:
undetectable		 4ejjA-4kcdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mcx KILLER PROTEIN

(Proteus
vulgaris) 		PF05015
(HigB-like_toxin) 		5 PHE B  78
ASN B  47
GLY B  44
ILE B  37
PHE B  76
 None
 1.36A 4ejjA-4mcxB:
undetectable		 4ejjA-4mcxB:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfz DBV8 PROTEIN

(Nonomuraea
gerenzanensis) 		no annotation 4 PHE A 224
GLY A 171
ILE A 131
PHE A 219
 None
 0.88A 4ejjA-4mfzA:
undetectable		 4ejjA-4mfzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrp ABC TRANSPORTER
RELATED PROTEIN

(Novosphingobium
aromaticivorans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 PHE A  23
GLY A 109
THR A 113
ILE A 151
 None
None
None
LDA  A 701 ( 4.7A)
 0.81A 4ejjA-4mrpA:
undetectable		 4ejjA-4mrpA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfd PAIRED
IMMUNOGLOBULIN-LIKE
TYPE 2 RECEPTOR BETA

(Homo sapiens) 		PF07686
(V-set) 		4 PHE A  25
GLY A  74
ILE A  39
PHE A  23
 None
 0.82A 4ejjA-4nfdA:
undetectable		 4ejjA-4nfdA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oen SECOND SUBSTRATE
BINDING DOMAIN OF
PUTATIVE AMINO ACID
ABC TRANSPORTER

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		4 PHE A 306
ASN A 466
GLY A 468
ILE A 297
 None
 0.88A 4ejjA-4oenA:
undetectable		 4ejjA-4oenA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF12157
(DUF3591) 		4 PHE A 662
GLY A 824
THR A 875
ILE A 872
 None
 0.89A 4ejjA-4oy2A:
undetectable		 4ejjA-4oy2A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq1 PUTATIVE ELECTRON
TRANSPORT RELATED
PROTEIN

(Corynebacterium
diphtheriae) 		PF00578
(AhpC-TSA) 		4 PHE A 139
ASN A 111
GLY A 109
ILE A  55
 None
 0.89A 4ejjA-4pq1A:
undetectable		 4ejjA-4pq1A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 4 PHE A 224
GLY A 171
ILE A 131
PHE A 219
 None
 0.81A 4ejjA-4q38A:
undetectable		 4ejjA-4q38A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfk ABC TRANSPORTER
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Pseudoalteromonas
sp. SM9913) 		no annotation 4 ASN H 386
GLY H 432
ILE H 421
PHE H 417
 None
 0.89A 4ejjA-4qfkH:
undetectable		 4ejjA-4qfkH:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE

(Brucella
abortus) 		PF01041
(DegT_DnrJ_EryC1) 		4 PHE A 203
GLY A 200
THR A 185
ILE A 167
 None
 0.79A 4ejjA-4qgrA:
undetectable		 4ejjA-4qgrA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CWC27 HOMOLOG

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 PHE A 113
PHE A  54
THR A  19
ILE A  24
PHE A 115
 None
 1.17A 4ejjA-4r3eA:
undetectable		 4ejjA-4r3eA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		4 PHE A 599
GLY A 730
ILE B 665
PHE A 603
 None
PQN  A5001 ( 4.0A)
CLA  B9023 ( 3.9A)
CLA  B9023 ( 4.5A)
 0.86A 4ejjA-4rkuA:
undetectable		 4ejjA-4rkuA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnr PGT130 HEAVY CHAIN
PGT130 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE B  98
PHE A 100
ASN A  60
GLY A  49
 None
 0.90A 4ejjA-4rnrB:
undetectable		 4ejjA-4rnrB:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trk C. ELEGANS HIM-3

(Caenorhabditis
elegans) 		PF02301
(HORMA) 		4 PHE A  25
THR A  24
ILE A  67
PHE A 165
 None
 0.90A 4ejjA-4trkA:
undetectable		 4ejjA-4trkA:
22.51