SIMILAR PATTERNS OF AMINO ACIDS FOR 4EJG_C_NCTC501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhd UTROPHIN

(Homo sapiens) 		PF00307
(CH) 		5 PHE A 215
ASN A 186
ALA A 184
LEU A 247
LEU A 250
 None
 1.09A 4ejgC-1bhdA:
undetectable		 4ejgC-1bhdA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg2 CARBOXYPEPTIDASE G2

(Pseudomonas sp.
RS-16) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 PHE A 171
ASN A 146
LEU A  77
LEU A  74
 None
 0.87A 4ejgC-1cg2A:
undetectable		 4ejgC-1cg2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fu1 DNA REPAIR PROTEIN
XRCC4

(Homo sapiens) 		PF06632
(XRCC4) 		4 PHE A  95
PHE A 111
ALA A  73
LEU A  28
 None
 0.63A 4ejgC-1fu1A:
undetectable		 4ejgC-1fu1A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 PHE A  45
ALA A 254
LEU A 212
LEU A 221
 None
 0.70A 4ejgC-1geyA:
0.0		 4ejgC-1geyA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksp PROTEIN (DNA
POLYMERASE I-KLENOW
FRAGMENT
(E.C.2.7.7.7))

(Escherichia
coli) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 PHE A 354
PHE A 352
PHE A 373
LEU A 368
 None
 0.84A 4ejgC-1kspA:
0.0		 4ejgC-1kspA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n47 ISOLECTIN B4

(Vicia villosa) 		PF00139
(Lectin_legB) 		4 PHE A   8
ASN A  17
ALA A  53
LEU A  20
 None
 0.78A 4ejgC-1n47A:
undetectable		 4ejgC-1n47A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 PHE A 196
PHE A 189
PHE A 152
LEU A 279
 None
 0.85A 4ejgC-1qf7A:
0.0		 4ejgC-1qf7A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rep PROTEIN (REPLICATION
INITIATION PROTEIN)

(Escherichia
coli) 		PF01051
(Rep_3) 		4 PHE C 139
ALA C  27
LEU C  31
LEU C  39
 None
 0.83A 4ejgC-1repC:
0.0		 4ejgC-1repC:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s98 PROTEIN YFHF

(Escherichia
coli) 		PF01521
(Fe-S_biosyn) 		4 PHE A  16
PHE A  44
LEU A  77
LEU A  26
 None
 0.88A 4ejgC-1s98A:
undetectable		 4ejgC-1s98A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szb MANNOSE BINDING
LECTIN-ASSOCIATED
SERINE PROTEASE-2
RELATED PROTEIN,
MAP19 (19KDA)

(Homo sapiens) 		PF00431
(CUB)
PF07645
(EGF_CA) 		4 PHE A  49
PHE A  46
ALA A  72
LEU A  44
 PHE  A  49 ( 1.3A)
PHE  A  46 ( 1.3A)
ALA  A  72 ( 0.0A)
LEU  A  44 ( 0.6A)
 0.62A 4ejgC-1szbA:
undetectable		 4ejgC-1szbA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szb MANNOSE BINDING
LECTIN-ASSOCIATED
SERINE PROTEASE-2
RELATED PROTEIN,
MAP19 (19KDA)

(Homo sapiens) 		PF00431
(CUB)
PF07645
(EGF_CA) 		4 PHE A  49
PHE A  46
LEU A  98
LEU A  44
 PHE  A  49 ( 1.3A)
PHE  A  46 ( 1.3A)
LEU  A  98 ( 0.6A)
LEU  A  44 ( 0.6A)
 0.87A 4ejgC-1szbA:
undetectable		 4ejgC-1szbA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szb MANNOSE BINDING
LECTIN-ASSOCIATED
SERINE PROTEASE-2
RELATED PROTEIN,
MAP19 (19KDA)

(Homo sapiens) 		PF00431
(CUB)
PF07645
(EGF_CA) 		4 PHE A 115
PHE A  49
PHE A  46
LEU A  44
 PHE  A 115 ( 1.3A)
PHE  A  49 ( 1.3A)
PHE  A  46 ( 1.3A)
LEU  A  44 ( 0.6A)
 0.80A 4ejgC-1szbA:
undetectable		 4ejgC-1szbA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tc5 PROBABLE EUKARYOTIC
D-AMINO ACID TRNA
DEACYLASE,
LMAJ005534AAA

(Leishmania
major) 		PF02580
(Tyr_Deacylase) 		4 PHE A  71
PHE A  74
LEU A  65
LEU A  86
 None
 0.83A 4ejgC-1tc5A:
undetectable		 4ejgC-1tc5A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 PHE A 116
ALA A 241
LEU A 165
LEU A 218
 HEM  A1430 (-4.7A)
PG4  A4502 (-4.3A)
None
None
 0.92A 4ejgC-1uedA:
28.9		 4ejgC-1uedA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4u HEMOGLOBIN BETA
CHAIN

(Thunnus thynnus) 		PF00042
(Globin) 		4 PHE B 130
PHE B 122
LEU B  68
LEU B  18
 None
 0.89A 4ejgC-1v4uB:
undetectable		 4ejgC-1v4uB:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy2 XAA-PRO DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 PHE A 101
ALA A 109
LEU A  46
LEU A  24
 None
 0.86A 4ejgC-1wy2A:
undetectable		 4ejgC-1wy2A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Saccharomyces
cerevisiae) 		no annotation 4 ASN A 149
ALA A 145
LEU A 119
LEU A 116
 None
 0.90A 4ejgC-2hsmA:
undetectable		 4ejgC-2hsmA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Caldanaerobacter
subterraneus) 		PF13407
(Peripla_BP_4) 		4 PHE A  16
PHE A  15
ALA A 137
LEU A 266
 RIP  A 401 (-4.5A)
RIP  A 401 (-3.6A)
RIP  A 401 (-3.2A)
None
 0.92A 4ejgC-2ioyA:
undetectable		 4ejgC-2ioyA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixf ANTIGEN PEPTIDE
TRANSPORTER 1

(Rattus
norvegicus) 		PF00005
(ABC_tran) 		5 PHE A 482
PHE A 503
ALA A 525
LEU A 640
LEU A 505
 None
 1.05A 4ejgC-2ixfA:
undetectable		 4ejgC-2ixfA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A 217
PHE A 218
LEU A 262
LEU A 259
 None
 0.81A 4ejgC-2jiiA:
undetectable		 4ejgC-2jiiA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kd7 PUTATIVE CHITOBIASE

(Bacteroides
thetaiotaomicron) 		PF00754
(F5_F8_type_C) 		4 PHE A 105
ALA A 138
LEU A  33
LEU A 126
 None
 0.89A 4ejgC-2kd7A:
undetectable		 4ejgC-2kd7A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kd7 PUTATIVE CHITOBIASE

(Bacteroides
thetaiotaomicron) 		PF00754
(F5_F8_type_C) 		4 PHE A 105
ASN A 134
ALA A 138
LEU A 126
 None
 0.92A 4ejgC-2kd7A:
undetectable		 4ejgC-2kd7A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mf4 HYBRID POLYKETIDE
SYNTHASE-NON
RIBOSOMAL PEPTIDE
SYNTHETASE

(Streptomyces
virginiae) 		PF00550
(PP-binding) 		4 PHE A6763
ALA A6803
LEU A6745
LEU A6746
 None
 0.89A 4ejgC-2mf4A:
undetectable		 4ejgC-2mf4A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nra PI PROTEIN

(Escherichia
coli) 		PF01051
(Rep_3) 		4 PHE C 246
PHE C 261
ALA C 231
LEU C 198
 None
 0.66A 4ejgC-2nraC:
undetectable		 4ejgC-2nraC:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		4 PHE A 193
ASN A 217
LEU A 225
LEU A 212
 None
 0.86A 4ejgC-2omvA:
undetectable		 4ejgC-2omvA:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		4 PHE A 107
PHE A 111
PHE A 118
LEU A 370
 None
None
None
HEM  A 500 ( 3.8A)
 0.57A 4ejgC-2pg6A:
62.5		 4ejgC-2pg6A:
94.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqm NEUROPILIN-1

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		4 PHE A 258
PHE A 192
PHE A 189
LEU A 187
 None
 0.76A 4ejgC-2qqmA:
undetectable		 4ejgC-2qqmA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqo NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		4 PHE A 194
PHE A 191
LEU A 245
LEU A 189
 None
 0.86A 4ejgC-2qqoA:
undetectable		 4ejgC-2qqoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqo NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		4 PHE A 260
PHE A 194
PHE A 191
LEU A 189
 None
 0.82A 4ejgC-2qqoA:
undetectable		 4ejgC-2qqoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uy3 ENDOCHITINASE

(Saccharomyces
cerevisiae) 		PF00704
(Glyco_hydro_18) 		4 PHE A 208
PHE A 245
PHE A 210
LEU A  57
 None
 0.91A 4ejgC-2uy3A:
undetectable		 4ejgC-2uy3A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vun ENAMIDASE

(Eubacterium
barkeri) 		PF01979
(Amidohydro_1) 		4 PHE A 188
ALA A 118
LEU A 146
LEU A 142
 None
GOL  A1390 ( 3.7A)
None
None
 0.93A 4ejgC-2vunA:
undetectable		 4ejgC-2vunA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yiu CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT

(Paracoccus
denitrificans) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
PF00355
(Rieske)
PF10399
(UCR_Fe-S_N) 		4 PHE A 264
ALA C  34
LEU A  93
LEU A  96
 None
 0.92A 4ejgC-2yiuA:
undetectable		 4ejgC-2yiuA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 PHE A 165
ALA A 222
LEU A 231
LEU A 210
 None
 0.85A 4ejgC-2z65A:
undetectable		 4ejgC-2z65A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 PHE A  72
PHE A  73
ALA A 168
LEU A 213
 None
 0.91A 4ejgC-2ztgA:
undetectable		 4ejgC-2ztgA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 PHE B 393
PHE B 392
LEU B 455
LEU B 435
 None
 0.69A 4ejgC-3a79B:
undetectable		 4ejgC-3a79B:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqs BACTERIAL REGULATORY
PROTEINS, TETR
FAMILY

(Corynebacterium
glutamicum) 		PF00440
(TetR_N) 		4 PHE A 128
ALA A  85
LEU A 142
LEU A 138
 None
 0.91A 4ejgC-3aqsA:
undetectable		 4ejgC-3aqsA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7q XISI PROTEIN-LIKE

(Nostoc
punctiforme) 		PF08869
(XisI) 		4 PHE A  97
ALA A  80
LEU A  14
LEU A  61
 None
 0.92A 4ejgC-3d7qA:
undetectable		 4ejgC-3d7qA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm8 UNCHARACTERIZED
PROTEIN RPA4348

(Rhodopseudomonas
palustris) 		PF12680
(SnoaL_2) 		4 PHE A  44
PHE A  46
PHE A  47
LEU A 123
 None
 0.87A 4ejgC-3dm8A:
undetectable		 4ejgC-3dm8A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoq PUTATIVE ZINC
PROTEASE

(Thermus
thermophilus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 PHE A  68
ALA A  77
LEU A 106
LEU A 105
 None
 0.86A 4ejgC-3eoqA:
undetectable		 4ejgC-3eoqA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gha DISULFIDE BOND
FORMATION PROTEIN D

(Bacillus
subtilis) 		PF13462
(Thioredoxin_4) 		4 PHE A 128
PHE A 125
ALA A 111
LEU A 168
 None
 0.88A 4ejgC-3ghaA:
undetectable		 4ejgC-3ghaA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lca PROTEIN TOM71

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF14559
(TPR_19) 		4 PHE A 273
PHE A 276
ASN A 379
LEU A 302
 None
 0.93A 4ejgC-3lcaA:
undetectable		 4ejgC-3lcaA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lca PROTEIN TOM71

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF14559
(TPR_19) 		4 PHE A 273
PHE A 276
ASN A 379
LEU A 320
 None
 0.82A 4ejgC-3lcaA:
undetectable		 4ejgC-3lcaA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mud DNA REPAIR PROTEIN
XRCC4,TROPOMYOSIN
ALPHA-1 CHAIN

(Gallus gallus;
Homo sapiens) 		PF06632
(XRCC4) 		4 PHE A  95
PHE A 111
ALA A  73
LEU A  28
 None
 0.74A 4ejgC-3mudA:
undetectable		 4ejgC-3mudA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		4 PHE A 143
PHE A 145
LEU A 199
LEU A  84
 None
 0.89A 4ejgC-3q31A:
undetectable		 4ejgC-3q31A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyb TBC1 DOMAIN FAMILY
MEMBER 4

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		5 PHE A1093
PHE A1097
ALA A1085
LEU A1125
LEU A1149
 None
 1.41A 4ejgC-3qybA:
undetectable		 4ejgC-3qybA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s88 ENVELOPE
GLYCOPROTEIN

(Sudan
ebolavirus) 		PF01611
(Filo_glycop) 		4 PHE I 160
PHE I 176
ALA I  82
LEU I 111
 None
 0.93A 4ejgC-3s88I:
undetectable		 4ejgC-3s88I:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbu HYPOTHETICAL
NTF2-LIKE PROTEIN

(Bacteroides
fragilis) 		PF14254
(DUF4348) 		4 PHE A 267
PHE A 177
ALA A 185
LEU A 254
 None
None
None
MLY  A 255 ( 4.5A)
 0.79A 4ejgC-3sbuA:
undetectable		 4ejgC-3sbuA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssm METHYLTRANSFERASE

(Micromonospora
griseorubida) 		no annotation 4 PHE A 291
PHE A 287
ALA A 336
LEU A 329
 None
 0.87A 4ejgC-3ssmA:
undetectable		 4ejgC-3ssmA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		4 PHE A 481
ALA A 515
LEU A 527
LEU A 508
 None
 0.87A 4ejgC-3t6qA:
undetectable		 4ejgC-3t6qA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w03 DNA REPAIR PROTEIN
XRCC4

(Homo sapiens) 		PF06632
(XRCC4) 		4 PHE C  95
PHE C 111
ALA C  73
LEU C  28
 None
 0.63A 4ejgC-3w03C:
undetectable		 4ejgC-3w03C:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD) 		4 PHE A  72
PHE A  73
ALA A 168
LEU A 213
 None
 0.76A 4ejgC-3wqyA:
undetectable		 4ejgC-3wqyA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz4 DOTI

(Legionella
pneumophila) 		PF11393
(T4BSS_DotI_IcmL) 		4 PHE A 202
PHE A 116
PHE A 108
ALA A  88
 None
 0.81A 4ejgC-3wz4A:
undetectable		 4ejgC-3wz4A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqb MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00431
(CUB)
PF14670
(FXa_inhibition) 		4 PHE A  65
PHE A  62
ALA A  88
LEU A  60
 None
None
CA  A 707 ( 4.9A)
None
 0.74A 4ejgC-4aqbA:
undetectable		 4ejgC-4aqbA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqb MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00431
(CUB)
PF14670
(FXa_inhibition) 		4 PHE A 131
PHE A  65
PHE A  62
LEU A  60
 None
 0.79A 4ejgC-4aqbA:
undetectable		 4ejgC-4aqbA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8c GLUCOSE-REPRESSIBLE
ALCOHOL
DEHYDROGENASE
TRANSCRIPTIONAL
EFFECTOR

(Saccharomyces
cerevisiae) 		PF03372
(Exo_endo_phos)
PF13855
(LRR_8) 		4 PHE D 410
ASN D 436
LEU D 454
LEU D 431
 None
 0.75A 4ejgC-4b8cD:
undetectable		 4ejgC-4b8cD:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT) 		4 PHE A 396
PHE A 392
ALA A 364
LEU A 474
 None
 0.89A 4ejgC-4bujA:
undetectable		 4ejgC-4bujA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 PHE A 343
ASN A 335
LEU A 394
LEU A 397
 None
 0.91A 4ejgC-4fnqA:
undetectable		 4ejgC-4fnqA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gou EHRGS-RHOGEF

(Entamoeba
histolytica) 		PF00615
(RGS)
PF00621
(RhoGEF) 		4 PHE A 212
PHE A 231
LEU A 322
LEU A 325
 None
 0.75A 4ejgC-4gouA:
undetectable		 4ejgC-4gouA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpp PROBABLE GLUTAMINE
SYNTHETASE

(Pseudomonas
aeruginosa) 		PF00120
(Gln-synt_C)
PF16952
(Gln-synt_N_2) 		4 PHE A 134
PHE A 222
ALA A 213
LEU A 139
 None
 0.90A 4ejgC-4hppA:
undetectable		 4ejgC-4hppA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hym TOPOISOMERASE IV,
SUBUNIT B

(Francisella
tularensis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 PHE A 236
PHE A 252
ALA A 348
LEU A 282
 None
 0.83A 4ejgC-4hymA:
undetectable		 4ejgC-4hymA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iox TRIPARTITE TERMINASE
SUBUNIT UL15

(Human
alphaherpesvirus
1) 		PF02499
(DNA_pack_C) 		4 PHE A 647
ALA A 482
LEU A 678
LEU A 681
 None
 0.91A 4ejgC-4ioxA:
undetectable		 4ejgC-4ioxA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isy CYSTEINE DESULFURASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		4 PHE A 302
PHE A 304
LEU A 371
LEU A 374
 None
 0.88A 4ejgC-4isyA:
undetectable		 4ejgC-4isyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7k CATION EFFLUX SYSTEM
PROTEIN CUSC

(Escherichia
coli) 		PF02321
(OEP) 		4 PHE A 120
ALA A  70
LEU A 148
LEU A 147
 None
 0.85A 4ejgC-4k7kA:
undetectable		 4ejgC-4k7kA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkr RBMA PROTEIN

(Vibrio cholerae) 		no annotation 4 PHE A 149
ALA A  90
LEU A  62
LEU A  44
 None
 0.86A 4ejgC-4kkrA:
undetectable		 4ejgC-4kkrA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq8 SCA-FAMILY PROTEIN

(Rickettsia
rickettsii) 		PF12574
(120_Rick_ant) 		4 PHE A 138
PHE A 139
ALA A 151
LEU A 161
 None
 0.85A 4ejgC-4lq8A:
undetectable		 4ejgC-4lq8A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuf MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
NUCLEAR RECEPTOR
SUBFAMILY 0 GROUP B
MEMBER 2 CHIMERIC
CONSTRUCT

(Escherichia
coli;
Mus musculus) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 PHE A1240
ALA A1067
LEU A1253
LEU A1252
 None
 0.89A 4ejgC-4nufA:
undetectable		 4ejgC-4nufA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwz FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Caldalkalibacillus
thermarum) 		PF07992
(Pyr_redox_2) 		4 PHE A 295
ALA A 332
LEU A  26
LEU A  22
 None
 0.75A 4ejgC-4nwzA:
undetectable		 4ejgC-4nwzA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqs CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 PHE A 362
PHE A 366
ALA A 255
LEU A 330
 None
 0.90A 4ejgC-4oqsA:
29.4		 4ejgC-4oqsA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pay SIDC, INTERAPTIN

(Legionella
pneumophila) 		no annotation 4 PHE A 376
ALA A 358
LEU A 416
LEU A 414
 None
 0.93A 4ejgC-4payA:
undetectable		 4ejgC-4payA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2w PUTATIVE
ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE

(Streptococcus
pneumoniae) 		PF01832
(Glucosaminidase) 		4 PHE A 247
PHE A 134
ALA A 252
LEU A 121
 None
 0.90A 4ejgC-4q2wA:
undetectable		 4ejgC-4q2wA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud4 POLY(A) RNA
POLYMERASE PROTEIN
CID1

(Schizosaccharomyces
pombe) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		4 PHE A 275
PHE A 276
ALA A 196
LEU A 373
 None
 0.92A 4ejgC-4ud4A:
undetectable		 4ejgC-4ud4A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uj6 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		PF13205
(Big_5) 		4 ASN A  81
ALA A  84
LEU A  98
LEU A 101
 None
 0.93A 4ejgC-4uj6A:
undetectable		 4ejgC-4uj6A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE

(Sinorhizobium
meliloti) 		PF06253
(MTTB) 		4 PHE A 251
PHE A  76
ALA A 301
LEU A  69
 None
 0.85A 4ejgC-4yycA:
undetectable		 4ejgC-4yycA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aqa OFF7_DB04V3

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13354
(Beta-lactamase2) 		4 ASN A 262
ALA A 265
LEU A 292
LEU A 299
 None
 0.91A 4ejgC-5aqaA:
undetectable		 4ejgC-5aqaA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chx XRCC4-MYH7-1590-1657

(Homo sapiens) 		PF01576
(Myosin_tail_1)
PF06632
(XRCC4) 		4 PHE A  95
PHE A 111
ALA A  73
LEU A  28
 None
None
MLY  A  72 ( 3.6A)
None
 0.75A 4ejgC-5chxA:
undetectable		 4ejgC-5chxA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckm MANNAN-BINDING
LECTIN SERINE
PEPTIDASE 2

(Rattus
norvegicus) 		PF00431
(CUB)
PF07645
(EGF_CA) 		5 PHE A  45
PHE A  42
ALA A  68
LEU A  94
LEU A  40
 None
 0.63A 4ejgC-5ckmA:
undetectable		 4ejgC-5ckmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckm MANNAN-BINDING
LECTIN SERINE
PEPTIDASE 2

(Rattus
norvegicus) 		PF00431
(CUB)
PF07645
(EGF_CA) 		4 PHE A 111
PHE A  45
PHE A  42
LEU A  40
 None
 0.69A 4ejgC-5ckmA:
undetectable		 4ejgC-5ckmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckq MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Rattus
norvegicus) 		PF00431
(CUB)
PF14670
(FXa_inhibition) 		4 PHE A  46
PHE A  43
ALA A  69
LEU A  41
 None
 0.73A 4ejgC-5ckqA:
undetectable		 4ejgC-5ckqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckq MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Rattus
norvegicus) 		PF00431
(CUB)
PF14670
(FXa_inhibition) 		4 PHE A 112
PHE A  46
PHE A  43
LEU A  41
 None
 0.82A 4ejgC-5ckqA:
undetectable		 4ejgC-5ckqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dne L-ASPARAGINASE

(Cavia porcellus) 		PF00710
(Asparaginase) 		4 PHE A 110
ALA A  97
LEU A 228
LEU A 133
 None
 0.67A 4ejgC-5dneA:
undetectable		 4ejgC-5dneA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dnw SHKAI2IB

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		4 PHE A  91
PHE A 112
ALA A  74
LEU A  81
 None
 0.78A 4ejgC-5dnwA:
undetectable		 4ejgC-5dnwA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dp2 CURF

(Lyngbya
majuscula) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 PHE A 177
ALA A 141
LEU A 294
LEU A 303
 None
 0.60A 4ejgC-5dp2A:
undetectable		 4ejgC-5dp2A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2e BETA-LACTAMASE

(Yersinia
enterocolitica) 		PF13354
(Beta-lactamase2) 		4 ASN A 109
ALA A 112
LEU A 139
LEU A 146
 None
 0.90A 4ejgC-5e2eA:
undetectable		 4ejgC-5e2eA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 PHE B 121
PHE B 141
LEU B  46
LEU B 117
 None
 0.90A 4ejgC-5gqrB:
undetectable		 4ejgC-5gqrB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj3 ENVELOPE
GLYCOPROTEIN

(Ebola virus sp.) 		PF01611
(Filo_glycop) 		4 PHE C 160
PHE C 176
ALA C  82
LEU C 111
 None
 0.89A 4ejgC-5hj3C:
undetectable		 4ejgC-5hj3C:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1d PHOSPHATE BINDING
PROTEIN

(Stenotrophomonas
maltophilia) 		PF12849
(PBP_like_2) 		4 PHE A 291
PHE A  58
PHE A 293
LEU A 310
 None
 0.92A 4ejgC-5j1dA:
undetectable		 4ejgC-5j1dA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k22 PROTEIN TYROSINE
PHOSPHATASE TYPE IVA
2

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 PHE A  16
ALA A 119
LEU A  82
LEU A  85
 None
 0.93A 4ejgC-5k22A:
undetectable		 4ejgC-5k22A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k47 POLYCYSTIN-2

(Homo sapiens) 		PF08016
(PKD_channel) 		4 ASN A 525
ALA A 521
LEU A 234
LEU A 237
 None
 0.92A 4ejgC-5k47A:
undetectable		 4ejgC-5k47A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2

(Homo sapiens) 		no annotation 4 PHE B  66
ALA B  32
LEU B 214
LEU B  64
 None
 0.84A 4ejgC-5ofbB:
undetectable		 4ejgC-5ofbB:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2g PENICILLIN-BINDING
PROTEIN 1A

(Haemophilus
influenzae) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		4 PHE A  82
ALA A 179
LEU A 191
LEU A  78
 None
 0.90A 4ejgC-5u2gA:
undetectable		 4ejgC-5u2gA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj4 UNCHARACTERIZED
PROTEIN

(Borrelia
turicatae) 		no annotation 4 PHE A 271
ALA A 193
LEU A 181
LEU A 210
 None
 0.91A 4ejgC-5vj4A:
undetectable		 4ejgC-5vj4A:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 4 PHE A 108
PHE A 115
ALA A 298
LEU A 363
 9ZJ  A 502 (-4.4A)
9ZJ  A 502 (-4.7A)
9ZJ  A 502 ( 3.5A)
HEM  A 501 (-4.3A)
 0.46A 4ejgC-5wbgA:
56.5		 4ejgC-5wbgA:
65.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wj7 DNA REPAIR PROTEIN
XRCC4,MYOSIN-7

(Homo sapiens) 		PF06632
(XRCC4) 		4 PHE A  95
PHE A 111
ALA A  73
LEU A  28
 None
 0.66A 4ejgC-5wj7A:
undetectable		 4ejgC-5wj7A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm4 SALICYLATE-AMP
LIGASE

(Streptomyces
gandocaensis) 		no annotation 5 PHE A 114
PHE A 113
ALA A 260
LEU A 209
LEU A 125
 None
 1.00A 4ejgC-5wm4A:
undetectable		 4ejgC-5wm4A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqw N-ACETYLGLUCOSAMINID
ASE

(Clostridium
perfringens) 		PF01832
(Glucosaminidase) 		4 PHE A1021
ASN A1019
ALA A1055
LEU A 944
 EDO  A1202 (-4.7A)
EDO  A1202 (-3.7A)
EDO  A1202 (-3.6A)
None
 0.87A 4ejgC-5wqwA:
undetectable		 4ejgC-5wqwA:
19.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 4 PHE A 114
ALA A 297
LEU A 362
LEU A 366
 LSN  A 503 (-3.8A)
LSN  A 501 ( 3.3A)
LSN  A 503 ( 3.7A)
HEM  A 504 ( 4.4A)
 0.81A 4ejgC-5xxiA:
49.5		 4ejgC-5xxiA:
50.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0q UPF0348 PROTEIN
B4417_3650

(Bacillus
subtilis) 		no annotation 4 ASN A 218
ALA A 213
LEU A 226
LEU A 223
 None
 0.93A 4ejgC-5y0qA:
undetectable		 4ejgC-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6acd -

(-) 		no annotation 4 PHE A 325
PHE A 329
LEU A 374
LEU A 355
 None
 0.92A 4ejgC-6acdA:
undetectable		 4ejgC-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2

(Mycobacterium
tuberculosis) 		no annotation 4 PHE A 107
ALA A 241
LEU A 245
LEU A 227
 None
 0.91A 4ejgC-6ayvA:
undetectable		 4ejgC-6ayvA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN

(Xanthomonas
campestris) 		no annotation 4 PHE A 321
PHE A 318
PHE A 317
ALA A 430
 None
 0.90A 4ejgC-6ei3A:
undetectable		 4ejgC-6ei3A:
22.97