SIMILAR PATTERNS OF AMINO ACIDS FOR 4EJG_B_NCTB501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a75 PARVALBUMIN

(Merlangius
merlangus) 		PF13499
(EF-hand_7) 		4 PHE A  66
PHE A  85
PHE A  29
LEU A 105
 None
 0.82A 4ejgB-1a75A:
undetectable		 4ejgB-1a75A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhd UTROPHIN

(Homo sapiens) 		PF00307
(CH) 		5 PHE A 215
ASN A 186
ALA A 184
LEU A 247
LEU A 250
 None
 1.04A 4ejgB-1bhdA:
undetectable		 4ejgB-1bhdA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg2 CARBOXYPEPTIDASE G2

(Pseudomonas sp.
RS-16) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 PHE A 171
ASN A 146
LEU A  77
LEU A  74
 None
 0.77A 4ejgB-1cg2A:
0.0		 4ejgB-1cg2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)

(Physarum
polycephalum) 		PF09192
(Act-Frag_cataly) 		4 PHE A 266
ALA A 195
LEU A 252
LEU A 255
 None
 0.80A 4ejgB-1cjaA:
0.0		 4ejgB-1cjaA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
[FE]-HYDROGENASE
(SMALL SUBUNIT)

(Desulfovibrio
desulfuricans) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF13187
(Fer4_9) 		5 PHE A 147
ASN A 207
ALA A 209
LEU D  76
LEU D  71
 None
 1.28A 4ejgB-1e08A:
undetectable		 4ejgB-1e08A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsu N-ACETYLGALACTOSAMIN
E-4-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase) 		4 PHE A 162
ALA A 237
LEU A  98
LEU A  99
 None
 0.84A 4ejgB-1fsuA:
undetectable		 4ejgB-1fsuA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fvf SEC1

(Doryteuthis
pealeii) 		PF00995
(Sec1) 		4 ASN A 195
PHE A 198
ALA A 199
LEU A 228
 None
 0.75A 4ejgB-1fvfA:
undetectable		 4ejgB-1fvfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 PHE A  45
ALA A 254
LEU A 212
LEU A 221
 None
 0.71A 4ejgB-1geyA:
0.0		 4ejgB-1geyA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmk SURFACTIN SYNTHETASE

(Bacillus
subtilis) 		PF00975
(Thioesterase) 		5 PHE C  49
PHE C  24
ALA C  62
LEU C  74
LEU C  76
 None
 1.14A 4ejgB-1jmkC:
0.0		 4ejgB-1jmkC:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt9 DIADENOSINE
TETRAPHOSPHATE
HYDROLASE

(Caenorhabditis
elegans) 		PF00293
(NUDIX) 		4 ALA A  57
THR A  53
LEU A  64
LEU A  92
 None
 0.81A 4ejgB-1kt9A:
undetectable		 4ejgB-1kt9A:
13.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 PHE A 114
ALA A 294
THR A 298
LEU A 359
 DIF  A 501 (-4.5A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
DIF  A 501 (-4.4A)
 0.82A 4ejgB-1nr6A:
50.0		 4ejgB-1nr6A:
54.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2z HEXON PROTEIN

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 PHE A 727
ALA A 694
LEU A 662
LEU A 383
 None
 0.88A 4ejgB-1p2zA:
undetectable		 4ejgB-1p2zA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rep PROTEIN (REPLICATION
INITIATION PROTEIN)

(Escherichia
coli) 		PF01051
(Rep_3) 		4 PHE C 139
ALA C  27
LEU C  31
LEU C  39
 None
 0.87A 4ejgB-1repC:
undetectable		 4ejgB-1repC:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 PHE C 100
ALA C 101
THR C 141
LEU C 116
 None
 0.88A 4ejgB-1sxjC:
undetectable		 4ejgB-1sxjC:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5u SET BINDING FACTOR 1

(Mus musculus) 		PF00169
(PH) 		4 PHE A  91
PHE A  80
PHE A  29
LEU A  55
 None
 0.79A 4ejgB-1v5uA:
undetectable		 4ejgB-1v5uA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgq ETHANOL DECREASED 4
FYVE, RHOGEF AND PH
DOMAIN CONTAINING 6

(Mus musculus) 		PF00169
(PH) 		4 PHE A  83
PHE A  71
PHE A  29
LEU A  53
 None
 0.93A 4ejgB-1wgqA:
undetectable		 4ejgB-1wgqA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy2 XAA-PRO DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 PHE A 101
ALA A 109
LEU A  46
LEU A  24
 None
 0.88A 4ejgB-1wy2A:
undetectable		 4ejgB-1wy2A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfm FUMARASE

(Saccharomyces
cerevisiae) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 PHE A 169
PHE A  74
ALA A  73
LEU A 395
 None
 0.88A 4ejgB-1yfmA:
undetectable		 4ejgB-1yfmA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ah6 BH1595, UNKNOWN
CONSERVED PROTEIN

(Bacillus
halodurans) 		PF01923
(Cob_adeno_trans) 		4 ALA A  29
THR A  33
LEU A 154
LEU A 151
 None
 0.92A 4ejgB-2ah6A:
undetectable		 4ejgB-2ah6A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		4 ASN A 285
ALA A 287
THR A 328
LEU A 306
 None
 0.91A 4ejgB-2c4mA:
undetectable		 4ejgB-2c4mA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		4 PHE A 125
ALA A 317
THR A 321
LEU A 382
 None
HEM  A 900 ( 3.5A)
HEM  A 900 ( 3.1A)
HEM  A 900 (-4.0A)
 0.68A 4ejgB-2hi4A:
42.9		 4ejgB-2hi4A:
33.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Saccharomyces
cerevisiae) 		no annotation 4 ASN A 149
ALA A 145
LEU A 119
LEU A 116
 None
 0.89A 4ejgB-2hsmA:
undetectable		 4ejgB-2hsmA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hx1 PREDICTED SUGAR
PHOSPHATASES OF THE
HAD SUPERFAMILY

(Cytophaga
hutchinsonii) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ALA A 279
THR A  37
LEU A  10
LEU A   9
 None
 0.90A 4ejgB-2hx1A:
undetectable		 4ejgB-2hx1A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i15 HYPOTHETICAL PROTEIN
MG296 HOMOLOG

(Mycoplasma
pneumoniae) 		PF09644
(Mg296) 		4 PHE A 100
PHE A  62
ALA A  61
LEU A  54
 None
 0.89A 4ejgB-2i15A:
undetectable		 4ejgB-2i15A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iaf HYPOTHETICAL PROTEIN
SDHL

(Legionella
pneumophila) 		PF03315
(SDH_beta) 		4 ALA A 119
THR A  30
LEU A  86
LEU A  58
 None
 0.89A 4ejgB-2iafA:
undetectable		 4ejgB-2iafA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixf ANTIGEN PEPTIDE
TRANSPORTER 1

(Rattus
norvegicus) 		PF00005
(ABC_tran) 		5 PHE A 482
PHE A 503
ALA A 525
LEU A 640
LEU A 505
 None
 1.07A 4ejgB-2ixfA:
undetectable		 4ejgB-2ixfA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kd7 PUTATIVE CHITOBIASE

(Bacteroides
thetaiotaomicron) 		PF00754
(F5_F8_type_C) 		4 PHE A 105
ASN A 134
ALA A 138
LEU A 126
 None
 0.90A 4ejgB-2kd7A:
undetectable		 4ejgB-2kd7A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mf4 HYBRID POLYKETIDE
SYNTHASE-NON
RIBOSOMAL PEPTIDE
SYNTHETASE

(Streptomyces
virginiae) 		PF00550
(PP-binding) 		4 PHE A6763
ALA A6803
LEU A6745
LEU A6746
 None
 0.85A 4ejgB-2mf4A:
undetectable		 4ejgB-2mf4A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nra PI PROTEIN

(Escherichia
coli) 		PF01051
(Rep_3) 		4 PHE C 246
PHE C 261
ALA C 231
LEU C 198
 None
 0.73A 4ejgB-2nraC:
undetectable		 4ejgB-2nraC:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1)
PF13949
(ALIX_LYPXL_bnd) 		4 ALA A 490
THR A 493
LEU A 455
LEU A 458
 None
 0.91A 4ejgB-2r05A:
undetectable		 4ejgB-2r05A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE

(Escherichia
coli) 		PF02618
(YceG) 		4 PHE A 306
PHE A 316
PHE A 232
ALA A 229
 GOL  A 350 (-3.8A)
None
GOL  A 350 (-4.8A)
None
 0.92A 4ejgB-2r1fA:
undetectable		 4ejgB-2r1fA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvx CHELATASE, PUTATIVE

(Desulfovibrio
vulgaris) 		PF06180
(CbiK) 		4 PHE A 151
ALA A 134
LEU A 174
LEU A 171
 None
 0.91A 4ejgB-2xvxA:
undetectable		 4ejgB-2xvxA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 PHE A 165
ALA A 222
LEU A 231
LEU A 210
 None
 0.82A 4ejgB-2z65A:
undetectable		 4ejgB-2z65A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo sapiens) 		PF16113
(ECH_2) 		4 PHE A 194
PHE A 272
PHE A 291
ALA A 292
 None
 0.94A 4ejgB-3bptA:
undetectable		 4ejgB-3bptA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eat PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCB

(Pseudomonas
aeruginosa) 		PF02668
(TauD) 		4 PHE X  77
PHE X 122
ALA X 252
LEU X 249
 None
 0.87A 4ejgB-3eatX:
undetectable		 4ejgB-3eatX:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoq PUTATIVE ZINC
PROTEASE

(Thermus
thermophilus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 PHE A  68
ALA A  77
LEU A 106
LEU A 105
 None
 0.88A 4ejgB-3eoqA:
undetectable		 4ejgB-3eoqA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewb 2-ISOPROPYLMALATE
SYNTHASE

(Listeria
monocytogenes) 		PF00682
(HMGL-like) 		4 PHE X 265
ASN X 229
ALA X 239
THR X 210
 None
 0.88A 4ejgB-3ewbX:
undetectable		 4ejgB-3ewbX:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3z TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY

(Neisseria
meningitidis) 		PF01047
(MarR) 		4 PHE A  18
PHE A  32
ALA A  33
THR A  37
 None
 0.77A 4ejgB-3g3zA:
undetectable		 4ejgB-3g3zA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gza PUTATIVE
ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01120
(Alpha_L_fucos) 		4 PHE A  71
THR A  78
LEU A  95
LEU A 105
 None
 0.87A 4ejgB-3gzaA:
undetectable		 4ejgB-3gzaA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		4 PHE A 704
PHE A 700
LEU A 736
LEU A 735
 None
 0.89A 4ejgB-3hzjA:
undetectable		 4ejgB-3hzjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 PHE A 375
PHE A 397
PHE A 422
LEU A 357
 None
 0.86A 4ejgB-3iu1A:
undetectable		 4ejgB-3iu1A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		4 ASN A 561
PHE A 564
ALA A 524
THR A 527
 THH  A 642 ( 3.3A)
None
None
None
 0.86A 4ejgB-3k13A:
undetectable		 4ejgB-3k13A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2k PUTATIVE
CARBOXYPEPTIDASE

(Burkholderia
mallei) 		PF00246
(Peptidase_M14) 		4 PHE A  43
ALA A  74
THR A  88
LEU A  27
 None
 0.89A 4ejgB-3k2kA:
undetectable		 4ejgB-3k2kA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmu ALPHA-PARVIN

(Homo sapiens) 		PF00307
(CH) 		4 ASN B 326
PHE B 329
ALA B 330
LEU B 298
 None
 0.72A 4ejgB-3kmuB:
undetectable		 4ejgB-3kmuB:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A

(Shewanella
denitrificans) 		PF00246
(Peptidase_M14) 		4 PHE A 300
PHE A 359
ALA A 366
LEU A 334
 None
 0.92A 4ejgB-3l2nA:
undetectable		 4ejgB-3l2nA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwa ENVELOPE
GLYCOPROTEIN B

(Human
alphaherpesvirus
1) 		no annotation 4 ASN B 112
THR B 642
LEU B 617
LEU B 623
 None
 0.77A 4ejgB-3nwaB:
undetectable		 4ejgB-3nwaB:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 ASN A 331
ALA A 333
THR A 417
LEU A 277
 None
 0.94A 4ejgB-3ogrA:
undetectable		 4ejgB-3ogrA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbu HYPOTHETICAL
NTF2-LIKE PROTEIN

(Bacteroides
fragilis) 		PF14254
(DUF4348) 		5 PHE A 267
PHE A 177
PHE A 184
ALA A 185
LEU A 254
 None
None
None
None
MLY  A 255 ( 4.5A)
 0.79A 4ejgB-3sbuA:
undetectable		 4ejgB-3sbuA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		4 PHE A 481
ALA A 515
LEU A 527
LEU A 508
 None
 0.84A 4ejgB-3t6qA:
undetectable		 4ejgB-3t6qA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aek ENDOGLUCANASE CEL5A

([Eubacterium]
cellulosolvens) 		no annotation 4 PHE A  81
PHE A  75
PHE A 137
LEU A  94
 None
 0.90A 4ejgB-4aekA:
undetectable		 4ejgB-4aekA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8c GLUCOSE-REPRESSIBLE
ALCOHOL
DEHYDROGENASE
TRANSCRIPTIONAL
EFFECTOR

(Saccharomyces
cerevisiae) 		PF03372
(Exo_endo_phos)
PF13855
(LRR_8) 		4 PHE D 410
ASN D 436
LEU D 454
LEU D 431
 None
 0.70A 4ejgB-4b8cD:
undetectable		 4ejgB-4b8cD:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 PHE A 375
PHE A 397
PHE A 422
LEU A 357
 None
 0.85A 4ejgB-4c2xA:
undetectable		 4ejgB-4c2xA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em8 RIBOSE 5-PHOSPHATE
ISOMERASE B

(Anaplasma
phagocytophilum) 		PF02502
(LacAB_rpiB) 		4 PHE A 107
PHE A 124
LEU A  24
LEU A  20
 None
 0.92A 4ejgB-4em8A:
undetectable		 4ejgB-4em8A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewj ENOLASE 2

(Streptococcus
suis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ALA A 161
THR A 215
LEU A 282
LEU A 279
 None
 0.88A 4ejgB-4ewjA:
undetectable		 4ejgB-4ewjA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 PHE A 343
ASN A 335
LEU A 394
LEU A 397
 None
 0.93A 4ejgB-4fnqA:
undetectable		 4ejgB-4fnqA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		4 PHE A 290
ALA A 291
THR A 295
LEU A 356
 VNT  A 502 (-4.4A)
HEM  A 501 ( 3.5A)
VNT  A 502 ( 3.2A)
VNT  A 502 ( 4.5A)
 0.64A 4ejgB-4g3jA:
31.4		 4ejgB-4g3jA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyn CHEC, INHIBITOR OF
MCP METHYLATION /
FLIN FUSION PROTEIN

(Thermotoga
maritima) 		PF04509
(CheC) 		4 PHE A 188
PHE A 200
ALA A  44
LEU A  96
 None
 0.86A 4ejgB-4hynA:
undetectable		 4ejgB-4hynA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iox TRIPARTITE TERMINASE
SUBUNIT UL15

(Human
alphaherpesvirus
1) 		PF02499
(DNA_pack_C) 		4 PHE A 647
ALA A 482
LEU A 678
LEU A 681
 None
 0.91A 4ejgB-4ioxA:
undetectable		 4ejgB-4ioxA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isy CYSTEINE DESULFURASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		4 PHE A 302
PHE A 304
LEU A 371
LEU A 374
 None
 0.86A 4ejgB-4isyA:
undetectable		 4ejgB-4isyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7k CATION EFFLUX SYSTEM
PROTEIN CUSC

(Escherichia
coli) 		PF02321
(OEP) 		4 PHE A 120
ALA A  70
LEU A 148
LEU A 147
 None
 0.83A 4ejgB-4k7kA:
undetectable		 4ejgB-4k7kA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mag SIALIC ACID BINDING
PROTEIN

(Vibrio cholerae) 		PF03480
(DctP) 		4 ASN A 201
ALA A 203
THR A 205
LEU A 142
 None
 0.92A 4ejgB-4magA:
undetectable		 4ejgB-4magA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4noi DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA

(Campylobacter
jejuni) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 PHE A 103
PHE A 141
LEU A  88
LEU A  85
 None
 0.92A 4ejgB-4noiA:
undetectable		 4ejgB-4noiA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuf MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
NUCLEAR RECEPTOR
SUBFAMILY 0 GROUP B
MEMBER 2 CHIMERIC
CONSTRUCT

(Escherichia
coli;
Mus musculus) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 PHE A1240
ALA A1067
LEU A1253
LEU A1252
 None
 0.92A 4ejgB-4nufA:
undetectable		 4ejgB-4nufA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pay SIDC, INTERAPTIN

(Legionella
pneumophila) 		no annotation 4 PHE A 376
ALA A 358
LEU A 416
LEU A 414
 None
 0.93A 4ejgB-4payA:
undetectable		 4ejgB-4payA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqo L-SERINE DEHYDRATASE

(Legionella
pneumophila) 		PF03313
(SDH_alpha)
PF03315
(SDH_beta) 		4 ALA A 132
THR A  43
LEU A  99
LEU A  71
 None
 0.86A 4ejgB-4rqoA:
undetectable		 4ejgB-4rqoA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 PHE A 693
PHE A 666
ALA A 726
LEU A 621
 None
 0.90A 4ejgB-4tweA:
undetectable		 4ejgB-4tweA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1

(Mus musculus) 		PF01501
(Glyco_transf_8) 		4 PHE A 140
ALA A 117
LEU A 157
LEU A 154
 None
 0.74A 4ejgB-4wm0A:
undetectable		 4ejgB-4wm0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yei BETA1MUT

(synthetic
construct) 		PF00805
(Pentapeptide) 		4 ALA A 185
THR A 187
LEU A 192
LEU A 177
 None
 0.87A 4ejgB-4yeiA:
undetectable		 4ejgB-4yeiA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE

(Sinorhizobium
meliloti) 		PF06253
(MTTB) 		4 PHE A 251
PHE A  76
ALA A 301
LEU A  69
 None
 0.77A 4ejgB-4yycA:
undetectable		 4ejgB-4yycA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 PHE A 254
ALA A 277
LEU A 290
LEU A 296
 None
 0.94A 4ejgB-4z0cA:
undetectable		 4ejgB-4z0cA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdt STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX1

(Schizosaccharomyces
pombe) 		no annotation 4 PHE A 214
PHE A 240
ALA A 194
LEU A 182
 None
 0.86A 4ejgB-4zdtA:
undetectable		 4ejgB-4zdtA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzq CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
discoideum) 		PF00840
(Glyco_hydro_7) 		4 PHE A 119
PHE A 126
PHE A  16
LEU A 370
 None
 0.86A 4ejgB-4zzqA:
undetectable		 4ejgB-4zzqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckm MANNAN-BINDING
LECTIN SERINE
PEPTIDASE 2

(Rattus
norvegicus) 		PF00431
(CUB)
PF07645
(EGF_CA) 		4 PHE A  42
ALA A  68
LEU A  94
LEU A  40
 None
 0.58A 4ejgB-5ckmA:
undetectable		 4ejgB-5ckmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dne L-ASPARAGINASE

(Cavia porcellus) 		PF00710
(Asparaginase) 		4 PHE A 110
ALA A  97
LEU A 228
LEU A 133
 None
 0.69A 4ejgB-5dneA:
undetectable		 4ejgB-5dneA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dnw SHKAI2IB

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		4 PHE A  91
PHE A 112
ALA A  74
LEU A  81
 None
 0.77A 4ejgB-5dnwA:
undetectable		 4ejgB-5dnwA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dp2 CURF

(Lyngbya
majuscula) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 PHE A 177
ALA A 141
LEU A 294
LEU A 303
 None
 0.66A 4ejgB-5dp2A:
undetectable		 4ejgB-5dp2A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed7 TEGUMENT PROTEIN
UL21

(Human
alphaherpesvirus
1) 		PF03252
(Herpes_UL21) 		4 PHE A 501
ASN A 395
ALA A 393
LEU A 287
 None
 0.89A 4ejgB-5ed7A:
undetectable		 4ejgB-5ed7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyg INOSITOL
MONOPHOSPHATASE

(Staphylococcus
aureus) 		PF00459
(Inositol_P) 		4 PHE A  57
PHE A  54
PHE A  62
LEU A 107
 None
 0.90A 4ejgB-5eygA:
undetectable		 4ejgB-5eygA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 NICASTRIN

(Homo sapiens) 		PF05450
(Nicastrin) 		4 PHE A 103
PHE A 134
ASN A 169
ALA A 172
 None
 0.92A 4ejgB-5fn4A:
undetectable		 4ejgB-5fn4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2

(Arabidopsis
thaliana) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 PHE A 478
ALA A 406
LEU A 367
LEU A 370
 None
 0.85A 4ejgB-5gxuA:
undetectable		 4ejgB-5gxuA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 4 PHE A 520
PHE A 524
LEU A 505
LEU A 558
 None
 0.93A 4ejgB-5h3kA:
undetectable		 4ejgB-5h3kA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj3 ENVELOPE
GLYCOPROTEIN

(Ebola virus sp.) 		PF01611
(Filo_glycop) 		4 PHE C 160
PHE C 176
ALA C  82
LEU C 111
 None
 0.93A 4ejgB-5hj3C:
undetectable		 4ejgB-5hj3C:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 4 PHE C 198
ALA C 199
LEU C 450
LEU C 261
 None
 0.94A 4ejgB-5hr4C:
1.3		 4ejgB-5hr4C:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idu ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN

(Paraburkholderia
phymatum) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 PHE A  17
ALA A 313
THR A 254
LEU A  84
 None
 0.80A 4ejgB-5iduA:
undetectable		 4ejgB-5iduA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		4 PHE A 719
PHE A 699
LEU A 769
LEU A 742
 None
 0.92A 4ejgB-5irmA:
undetectable		 4ejgB-5irmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsc PUTATIVE ACYL-COA
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 PHE A  18
ALA A 314
THR A 255
LEU A  85
 None
 0.82A 4ejgB-5jscA:
undetectable		 4ejgB-5jscA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k47 POLYCYSTIN-2

(Homo sapiens) 		PF08016
(PKD_channel) 		4 ASN A 525
ALA A 521
LEU A 234
LEU A 237
 None
 0.90A 4ejgB-5k47A:
undetectable		 4ejgB-5k47A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		4 ASN A 486
ALA A 488
THR A 511
LEU A 135
 None
 0.93A 4ejgB-5k9tA:
undetectable		 4ejgB-5k9tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Homo sapiens) 		PF13191
(AAA_16)
PF14629
(ORC4_C) 		4 ALA C 188
THR C  54
LEU C  84
LEU C  81
 None
 0.81A 4ejgB-5uj7C:
undetectable		 4ejgB-5uj7C:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4l ADENYLOSUCCINATE
LYASE

(Cryptococcus
neoformans) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 PHE A 338
ALA A 182
LEU A 125
LEU A 124
 None
 0.83A 4ejgB-5v4lA:
undetectable		 4ejgB-5v4lA:
22.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 5 PHE A 115
PHE A 297
ALA A 298
THR A 302
LEU A 363
 9ZJ  A 502 (-4.7A)
9ZJ  A 502 ( 4.5A)
9ZJ  A 502 ( 3.5A)
9ZJ  A 502 ( 3.9A)
HEM  A 501 (-4.3A)
 0.60A 4ejgB-5wbgA:
56.4		 4ejgB-5wbgA:
65.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm4 SALICYLATE-AMP
LIGASE

(Streptomyces
gandocaensis) 		no annotation 4 PHE A 113
ALA A 260
LEU A 209
LEU A 125
 None
 0.77A 4ejgB-5wm4A:
undetectable		 4ejgB-5wm4A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqw N-ACETYLGLUCOSAMINID
ASE

(Clostridium
perfringens) 		PF01832
(Glucosaminidase) 		4 PHE A1021
ASN A1019
ALA A1055
LEU A 944
 EDO  A1202 (-4.7A)
EDO  A1202 (-3.7A)
EDO  A1202 (-3.6A)
None
 0.89A 4ejgB-5wqwA:
undetectable		 4ejgB-5wqwA:
19.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 4 PHE A 114
ALA A 297
LEU A 362
LEU A 366
 LSN  A 503 (-3.8A)
LSN  A 501 ( 3.3A)
LSN  A 503 ( 3.7A)
HEM  A 504 ( 4.4A)
 0.88A 4ejgB-5xxiA:
49.2		 4ejgB-5xxiA:
50.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0q UPF0348 PROTEIN
B4417_3650

(Bacillus
subtilis) 		no annotation 4 ASN A 218
ALA A 213
LEU A 226
LEU A 223
 None
 0.93A 4ejgB-5y0qA:
undetectable		 4ejgB-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yx3 CHALCONE-FLAVONONE
ISOMERASE FAMILY
PROTEIN

(Deschampsia
antarctica) 		no annotation 4 PHE A  26
PHE A  87
LEU A 211
LEU A 210
 None
 0.87A 4ejgB-5yx3A:
undetectable		 4ejgB-5yx3A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z24 PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 4 PHE A 274
ALA A 253
THR A 322
LEU A 265
 None
 0.92A 4ejgB-5z24A:
undetectable		 4ejgB-5z24A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6acd -

(-) 		no annotation 4 PHE A 325
PHE A 329
LEU A 374
LEU A 355
 None
 0.87A 4ejgB-6acdA:
undetectable		 4ejgB-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0w CENTROMERE PROTEIN N

(Homo sapiens) 		no annotation 4 PHE K 104
ALA K 161
THR K 163
LEU K 175
 PHE  K 104 ( 1.3A)
ALA  K 161 ( 0.0A)
THR  K 163 ( 0.8A)
LEU  K 175 ( 0.5A)
 0.91A 4ejgB-6c0wK:
undetectable		 4ejgB-6c0wK:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhe -

(-) 		no annotation 4 ASN A  34
ALA A  40
THR A  43
LEU A  50
 None
 0.90A 4ejgB-6fheA:
undetectable		 4ejgB-6fheA:
undetectable