SIMILAR PATTERNS OF AMINO ACIDS FOR 4EJ1_A_FOLA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fho UNC-89

(Caenorhabditis
elegans) 		no annotation 4 GLU A  97
ASP A  72
ARG A  12
THR A  68
 None
 1.48A 4ej1A-1fhoA:
0.0		 4ej1A-1fhoA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		4 GLU A 316
ASP A 211
ARG A 323
THR A 175
 None
None
None
GLN  A 501 (-4.2A)
 1.35A 4ej1A-2f2aA:
0.8		 4ej1A-2f2aA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		4 GLU A 309
ASP A 204
ARG A 316
THR A 168
 None
 1.38A 4ej1A-3h0lA:
0.4		 4ej1A-3h0lA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 5

(Thermus
thermophilus;
Thermus
thermophilus;
Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4)
PF00346
(Complex1_49kDa)
PF00329
(Complex1_30kDa) 		4 GLU 4 333
ASP 3 132
ARG 3 245
THR 5 182
 None
 0.94A 4ej1A-3i9v4:
undetectable		 4ej1A-3i9v4:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 GLU A 474
ASP A 471
ARG A 393
THR A 468
 None
 1.50A 4ej1A-3k30A:
0.0		 4ej1A-3k30A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 GLU E 301
ASP E 198
ARG E 308
THR E 162
 None
 1.26A 4ej1A-3kfuE:
0.3		 4ej1A-3kfuE:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 GLU A1147
ASP A1148
ARG A1086
THR A1144
 None
 1.37A 4ej1A-3s5kA:
0.0		 4ej1A-3s5kA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE

(Escherichia
coli) 		no annotation 4 GLU B  88
ASP B 166
ARG B 308
THR B 192
 None
PLG  B 401 (-2.7A)
PLG  B 401 (-3.3A)
None
 1.47A 4ej1A-3wlxB:
1.6		 4ej1A-3wlxB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c60 OCHRATOXINASE

(Aspergillus
niger) 		PF01979
(Amidohydro_1) 		4 GLU A 269
ASP A 225
ARG A 232
THR A 188
 None
 1.12A 4ej1A-4c60A:
undetectable		 4ej1A-4c60A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01425
(Amidase) 		4 GLU A 292
ASP A 187
ARG A 299
THR A 151
 None
None
None
GLN  A 501 (-4.4A)
 1.31A 4ej1A-4n0iA:
undetectable		 4ej1A-4n0iA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzq CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
discoideum) 		PF00840
(Glyco_hydro_7) 		4 GLU A 346
ASP A 347
ARG A 266
THR A 350
 None
 1.15A 4ej1A-4zzqA:
undetectable		 4ej1A-4zzqA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		4 GLU A 308
ASP A 312
ARG A 270
THR A 180
 None
 1.50A 4ej1A-5dpdA:
undetectable		 4ej1A-5dpdA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7

(Homo sapiens;
Homo sapiens) 		PF12157
(DUF3591)
PF04658
(TAFII55_N) 		4 GLU G 682
ASP H  81
ARG G 687
THR H  84
 None
 1.43A 4ej1A-5furG:
undetectable		 4ej1A-5furG:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5j NITROUS-OXIDE
REDUCTASE

(Shewanella
denitrificans) 		no annotation 4 GLU A  77
ASP A  98
ARG A 150
THR A 101
 None
 1.49A 4ej1A-5i5jA:
undetectable		 4ej1A-5i5jA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncs SERPIN

(Tannerella
forsythia) 		PF00079
(Serpin) 		4 GLU A 405
ASP A 223
ARG A 272
THR A 225
 None
 1.49A 4ej1A-5ncsA:
undetectable		 4ej1A-5ncsA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fa5 PUTATIVE MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		no annotation 4 GLU A 402
ASP A 383
ARG A 825
THR A 385
 None
 1.44A 4ej1A-6fa5A:
undetectable		 4ej1A-6fa5A:
undetectable