SIMILAR PATTERNS OF AMINO ACIDS FOR 4EIX_A_NIMA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ac5 KEX1(DELTA)P

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		4 LEU A 294
ALA A 228
ILE A 234
LYS A 302
 None
 1.39A 4eixA-1ac5A:
0.0		 4eixA-1ac5A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpp DIPEPTIDE BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 LEU A 458
ALA A 462
ILE A 443
LYS A 454
 None
 1.38A 4eixA-1dppA:
undetectable		 4eixA-1dppA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7o GLUTAREDOXIN 2

(Escherichia
coli) 		PF04399
(Glutaredoxin2_C)
PF13417
(GST_N_3) 		4 LEU A  51
ALA A  15
ILE A  18
LYS A  53
 None
 1.48A 4eixA-1g7oA:
0.0		 4eixA-1g7oA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gaj HIGH-AFFINITY
BRANCHED CHAIN AMINO
ACID TRANSPORT
ATP-BINDING PROTEIN

(Methanocaldococcus
jannaschii) 		PF00005
(ABC_tran) 		4 LEU A 199
ALA A 167
ILE A 164
LYS A 202
 None
 1.46A 4eixA-1gajA:
0.0		 4eixA-1gajA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggv DIENELACTONE
HYDROLASE

(Pseudomonas
putida) 		PF01738
(DLH) 		4 LEU A  19
ALA A  58
ILE A  33
LYS A   1
 None
 1.44A 4eixA-1ggvA:
0.0		 4eixA-1ggvA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i0r CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF01613
(Flavin_Reduct) 		4 LEU A 104
ALA A 115
ILE A 113
LYS A  96
 None
 1.42A 4eixA-1i0rA:
0.0		 4eixA-1i0rA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermotoga
maritima) 		PF00218
(IGPS) 		4 LEU A  59
ALA A  29
ILE A  36
LYS A  86
 None
 1.00A 4eixA-1j5tA:
0.0		 4eixA-1j5tA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE

(Escherichia
coli) 		PF00218
(IGPS) 		4 LEU P  87
ALA P  57
ILE P  64
LYS P 114
 None
None
None
137  P 400 (-2.4A)
 1.08A 4eixA-1jcmP:
0.0		 4eixA-1jcmP:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 LEU A 756
ALA A 714
ILE A 711
LYS A 759
 None
 1.49A 4eixA-1ldjA:
1.4		 4eixA-1ldjA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lk0 ARSENATE REDUCTASE

(Staphylococcus
aureus) 		PF01451
(LMWPc) 		4 LEU A  72
ALA A  37
ILE A   9
LYS A  73
 None
 1.45A 4eixA-1lk0A:
1.5		 4eixA-1lk0A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase) 		4 LEU A  41
ALA A  61
ILE A  89
LYS A  37
 None
None
None
ATP  A 700 ( 4.1A)
 1.27A 4eixA-1qhhA:
undetectable		 4eixA-1qhhA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s58 B19 PARVOVIRUS
CAPSID

(Primate
erythroparvovirus
1) 		PF00740
(Parvo_coat) 		4 LEU A 316
ALA A 351
ILE A 352
LYS A 314
 None
 1.34A 4eixA-1s58A:
undetectable		 4eixA-1s58A:
11.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s8h PHOSPHOLIPASE A2
HOMOLOG

(Agkistrodon
contortrix) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
ALA A  18
ILE A  19
LYS A  69
 None
 0.32A 4eixA-1s8hA:
20.9		 4eixA-1s8hA:
64.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snz ALDOSE 1-EPIMERASE

(Homo sapiens) 		PF01263
(Aldose_epim) 		4 LEU A 106
ALA A  80
ILE A  76
LYS A 101
 None
 1.31A 4eixA-1snzA:
undetectable		 4eixA-1snzA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkm METHIONINE
AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24) 		4 LEU A   6
ALA A  92
ILE A  91
LYS A   1
 None
 1.42A 4eixA-1wkmA:
undetectable		 4eixA-1wkmA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xer FERREDOXIN

(Sulfurisphaera
tokodaii) 		PF13187
(Fer4_9) 		4 LEU A  44
ALA A  70
ILE A  46
LYS A   1
 None
None
F3S  A 104 (-4.6A)
None
 1.08A 4eixA-1xerA:
undetectable		 4eixA-1xerA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y5e MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B

(Bacillus cereus) 		PF00994
(MoCF_biosynth) 		4 LEU A 149
ALA A 122
ILE A 118
LYS A 153
 None
 1.35A 4eixA-1y5eA:
undetectable		 4eixA-1y5eA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Pyrococcus
horikoshii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A 224
ALA A 274
ILE A 275
LYS A 186
 None
 1.32A 4eixA-2cxeA:
undetectable		 4eixA-2cxeA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d13 HYPOTHETICAL PROTEIN
PH1257

(Pyrococcus
horikoshii) 		PF01902
(Diphthami_syn_2) 		4 LEU A  54
ALA A 222
ILE A 203
LYS A  51
 None
 1.15A 4eixA-2d13A:
undetectable		 4eixA-2d13A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7h STRESS-INDUCED
PROTEIN SAM22

(Glycine max) 		PF00407
(Bet_v_1) 		4 LEU A 142
ALA A  33
ILE A  30
LYS A 138
 None
 1.03A 4eixA-2k7hA:
undetectable		 4eixA-2k7hA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lta DE NOVO DESIGNED
PROTEIN

(synthetic
construct) 		PF01515
(PTA_PTB) 		4 LEU A  49
ALA A  20
ILE A   8
LYS A  45
 None
 1.26A 4eixA-2ltaA:
undetectable		 4eixA-2ltaA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q62 ARSH

(Sinorhizobium
meliloti) 		PF03358
(FMN_red) 		4 LEU A  76
ALA A 119
ILE A 116
LYS A  88
 None
 1.33A 4eixA-2q62A:
1.6		 4eixA-2q62A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql2 NEUROGENIC
DIFFERENTIATION
FACTOR 1
TRANSCRIPTION FACTOR
E2-ALPHA

(Mus musculus) 		PF00010
(HLH) 		4 LEU B 143
ALA A 588
ILE A 584
LYS B 139
 None
 1.14A 4eixA-2ql2B:
undetectable		 4eixA-2ql2B:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc0 ALANINE GLYOXYLATE
TRANSAMINASE

(Thermococcus
litoralis) 		PF00155
(Aminotran_1_2) 		4 LEU A  94
ALA A  85
ILE A 101
LYS A 231
 None
 1.45A 4eixA-2zc0A:
undetectable		 4eixA-2zc0A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 648
ALA A 634
ILE A 638
LYS A 649
 None
 1.39A 4eixA-2zmcA:
undetectable		 4eixA-2zmcA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeu LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		4 LEU A 329
ALA A 325
ILE A 324
LYS A 331
 None
 1.41A 4eixA-3aeuA:
undetectable		 4eixA-3aeuA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Aquifex
aeolicus) 		PF01706
(FliG_C)
PF14841
(FliG_M)
PF14842
(FliG_N) 		4 LEU A 266
ALA A 307
ILE A 264
LYS A 274
 None
 1.27A 4eixA-3hjlA:
undetectable		 4eixA-3hjlA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihk THIAMIN
PYROPHOSPHOKINASE

(Streptococcus
mutans) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 LEU A  41
ALA A  79
ILE A  83
LYS A  63
 None
 1.25A 4eixA-3ihkA:
undetectable		 4eixA-3ihkA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iiu PERIDININ-CHLOROPHYL
L A-BINDING PROTEIN
1, CHLOROPLASTIC

(Amphidinium
carterae) 		PF02429
(PCP) 		4 LEU M  58
ALA M  90
ILE M   3
LYS M  57
 None
 1.40A 4eixA-3iiuM:
undetectable		 4eixA-3iiuM:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2

(Homo sapiens) 		PF00106
(adh_short) 		4 LEU A  69
ALA A  58
ILE A  54
LYS A  87
 None
 1.47A 4eixA-3kvoA:
undetectable		 4eixA-3kvoA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		4 LEU A 176
ALA A 263
ILE A 200
LYS A 174
 None
 1.49A 4eixA-3mdyA:
undetectable		 4eixA-3mdyA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om9 LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A  51
ALA A  24
ILE A  26
LYS A  62
 None
 1.18A 4eixA-3om9A:
undetectable		 4eixA-3om9A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pe8 ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		4 LEU A 169
ALA A 115
ILE A  95
LYS A 143
 None
 1.12A 4eixA-3pe8A:
undetectable		 4eixA-3pe8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Clostridium
perfringens) 		PF00698
(Acyl_transf_1) 		4 LEU A 222
ALA A 234
ILE A 225
LYS A 221
 None
 1.46A 4eixA-3ptwA:
undetectable		 4eixA-3ptwA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyr ECHA16_2

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 LEU A 168
ALA A 114
ILE A  94
LYS A 142
 None
 1.09A 4eixA-3qyrA:
undetectable		 4eixA-3qyrA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 493
ALA A 477
ILE A 475
LYS A 490
 None
 0.91A 4eixA-3r44A:
undetectable		 4eixA-3r44A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Brucella
abortus) 		PF00218
(IGPS) 		4 LEU A  95
ALA A  64
ILE A  71
LYS A 122
 None
 1.12A 4eixA-3tsmA:
undetectable		 4eixA-3tsmA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ar9 COLLAGENASE COLT

(Clostridium
tetani) 		PF01752
(Peptidase_M9) 		4 LEU A 480
ALA A 406
ILE A 442
LYS A 483
 None
 1.44A 4eixA-4ar9A:
undetectable		 4eixA-4ar9A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egv ACETYL-COA
ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		no annotation 4 LEU A 273
ALA A  52
ILE A  55
LYS A 272
 None
 1.29A 4eixA-4egvA:
undetectable		 4eixA-4egvA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		4 LEU W1017
ALA W1045
ILE W1042
LYS W1016
 None
 1.42A 4eixA-4f5xW:
undetectable		 4eixA-4f5xW:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		4 LEU A 449
ALA A 283
ILE A 286
LYS A 452
 None
None
None
SO4  A1003 (-3.3A)
 1.37A 4eixA-4ifqA:
undetectable		 4eixA-4ifqA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjt ENOYL-COA HYDRATASE

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		4 LEU A 168
ALA A 114
ILE A  94
LYS A 142
 None
 1.07A 4eixA-4jjtA:
undetectable		 4eixA-4jjtA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		4 LEU A 446
ALA A 483
ILE A 482
LYS A 442
 None
 1.45A 4eixA-4k17A:
undetectable		 4eixA-4k17A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber) 		PF01048
(PNP_UDP_1) 		4 LEU A 188
ALA A  69
ILE A  66
LYS A 191
 None
 1.42A 4eixA-4m3nA:
undetectable		 4eixA-4m3nA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nc2 TOXIN B

(Clostridioides
difficile) 		PF01473
(CW_binding_1) 		4 LEU A  88
ALA A  66
ILE A  53
LYS A  91
 None
 1.49A 4eixA-4nc2A:
undetectable		 4eixA-4nc2A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU B 247
ALA B 122
ILE B 121
LYS B 248
 None
 1.29A 4eixA-4o27B:
undetectable		 4eixA-4o27B:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI

(Staphylococcus
aureus) 		PF02976
(MutH) 		4 LEU A 256
ALA A 276
ILE A 277
LYS A 255
 None
 1.26A 4eixA-4pxgA:
undetectable		 4eixA-4pxgA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LEU A2417
ALA A2404
ILE A2288
LYS A2416
 None
 1.17A 4eixA-4rh7A:
undetectable		 4eixA-4rh7A:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Saccharomyces
cerevisiae) 		PF12569
(NARP1) 		4 LEU A 553
ALA A 670
ILE A 488
LYS A 549
 None
 1.41A 4eixA-4xpdA:
undetectable		 4eixA-4xpdA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Saccharomyces
cerevisiae) 		PF12569
(NARP1) 		4 LEU A 553
ALA A 671
ILE A 488
LYS A 549
 None
 0.87A 4eixA-4xpdA:
undetectable		 4eixA-4xpdA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 LEU A  41
ALA A 289
ILE A 286
LYS A  39
 None
 1.24A 4eixA-4yv7A:
undetectable		 4eixA-4yv7A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE

(Thiobacillus
denitrificans) 		PF13847
(Methyltransf_31) 		4 LEU A  67
ALA A  95
ILE A  65
LYS A   1
 SAH  A 301 (-3.8A)
SAH  A 301 (-3.6A)
None
None
 1.17A 4eixA-5epeA:
undetectable		 4eixA-5epeA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hei NFRA2

(Bacillus
megaterium) 		PF00881
(Nitroreductase) 		4 LEU A  60
ALA A  64
ILE A 137
LYS A  56
 None
 1.26A 4eixA-5heiA:
undetectable		 4eixA-5heiA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksw DIHYDROOROTATE
DEHYDROGENASE

(Lactococcus
lactis) 		PF01180
(DHO_dh) 		4 LEU A 232
ALA A 182
ILE A 181
LYS A 231
 None
 1.46A 4eixA-5kswA:
undetectable		 4eixA-5kswA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfb YIII(DQ)4CQI

(synthetic
construct) 		PF00514
(Arm) 		4 LEU A 145
ALA A 115
ILE A 119
LYS A 144
 None
 1.49A 4eixA-5mfbA:
undetectable		 4eixA-5mfbA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		4 LEU A 267
ALA A 196
ILE A 199
LYS A 332
 None
 1.37A 4eixA-5um2A:
undetectable		 4eixA-5um2A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wd8 LEM22

(Legionella
pneumophila) 		no annotation 4 LEU A  14
ALA A   9
ILE A  58
LYS A  70
 None
 1.28A 4eixA-5wd8A:
undetectable		 4eixA-5wd8A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3h URACIL-DNA
GLYCOSYLASE

(Nitratifractor
salsuginis) 		no annotation 4 LEU A 148
ALA A 123
ILE A 120
LYS A 145
 None
 1.10A 4eixA-5x3hA:
undetectable		 4eixA-5x3hA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xon PROTEIN THAT FORMS A
COMPLEX WITH SPT4P

(Komagataella
phaffii) 		PF00467
(KOW)
PF03439
(Spt5-NGN) 		4 LEU W 257
ALA W 281
ILE W 282
LYS W 246
 None
 1.47A 4eixA-5xonW:
undetectable		 4eixA-5xonW:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bma INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Campylobacter
jejuni) 		no annotation 4 LEU A  91
ALA A  60
ILE A  67
LYS A 118
 None
 1.10A 4eixA-6bmaA:
undetectable		 4eixA-6bmaA:
19.47