SIMILAR PATTERNS OF AMINO ACIDS FOR 4EIS_A_DAHA24

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE

(Bacillus
anthracis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 TYR A 228
PRO A 231
ASN A  90
PRO A  99
 None
 1.42A 4eisA-2btuA:
0.0
4eisB-2btuA:
0.0		 4eisA-2btuA:
18.26
4eisB-2btuA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF00496
(SBP_bac_5) 		4 TYR A 498
PRO A 117
ASN A 496
PRO A 121
 None
 1.41A 4eisA-2d5wA:
0.0
4eisB-2d5wA:
undetectable		 4eisA-2d5wA:
16.67
4eisB-2d5wA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atz DESIGNED ANKYRIN
REPEAT PROTEIN

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 TYR D  43
PRO D  50
MET D  53
PRO D  83
 None
 1.23A 4eisA-4atzD:
undetectable
4eisB-4atzD:
undetectable		 4eisA-4atzD:
21.49
4eisB-4atzD:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwc PHOSPHOLIPASE B-LIKE
1

(Bos taurus) 		PF04916
(Phospholip_B) 		4 TYR A  38
PRO A 109
ASN A  69
PRO B 278
 None
 1.37A 4eisA-4bwcA:
0.0
4eisB-4bwcA:
0.0		 4eisA-4bwcA:
18.78
4eisB-4bwcA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwc PHOSPHOLIPASE B-LIKE
1

(Bos taurus) 		PF04916
(Phospholip_B) 		4 TYR A  38
PRO A 109
MET A 111
ASN A  69
 None
 1.13A 4eisA-4bwcA:
0.0
4eisB-4bwcA:
0.0		 4eisA-4bwcA:
18.78
4eisB-4bwcA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 TYR A 511
PRO A 274
MET A 272
PRO A 270
 None
 1.27A 4eisA-4pfyA:
0.0
4eisB-4pfyA:
0.0		 4eisA-4pfyA:
16.86
4eisB-4pfyA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Neisseria
gonorrhoeae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 TYR A 227
PRO A 230
ASN A  91
PRO A 100
 None
 1.41A 4eisA-5vk4A:
0.0
4eisB-5vk4A:
0.0		 4eisA-5vk4A:
17.82
4eisB-5vk4A:
17.82