SIMILAR PATTERNS OF AMINO ACIDS FOR 4EIL_D_FOLD703

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		5 ALA A 237
SER A 215
PHE A 222
ARG A 177
THR A 238
 None
 1.48A 4eilD-1c2oA:
undetectable		 4eilD-1c2oA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cz3 DIHYDROFOLATE
REDUCTASE

(Thermotoga
maritima) 		PF00186
(DHFR_1) 		5 VAL A   6
ALA A   8
ASP A  27
ARG A  58
THR A 121
 None
 0.53A 4eilD-1cz3A:
17.2		 4eilD-1cz3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 VAL A 478
ALA A 463
PHE A 566
SER A 521
VAL A 479
 None
 1.25A 4eilD-1k72A:
undetectable		 4eilD-1k72A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		5 VAL A 469
ALA A 461
MET A 523
PHE A 407
VAL A 440
 None
 1.35A 4eilD-1su7A:
undetectable		 4eilD-1su7A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u70 DIHYDROFOLATE
REDUCTASE

(Mus musculus) 		PF00186
(DHFR_1) 		5 ALA A   9
PHE A  31
ARG A  70
VAL A 115
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 (-3.1A)
MTX  A 187 ( 4.0A)
MTX  A 187 (-4.4A)
 0.30A 4eilD-1u70A:
22.6		 4eilD-1u70A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2blb DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
vivax) 		PF00186
(DHFR_1) 		5 ALA A  15
ASP A  53
SER A  58
ARG A 131
THR A 194
 CP7  A1240 (-3.7A)
CP7  A1240 (-3.1A)
MES  A1241 (-3.1A)
MES  A1241 (-2.7A)
CP7  A1240 (-4.1A)
 0.39A 4eilD-2blbA:
21.4		 4eilD-2blbA:
18.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 VAL A  26
ALA A  28
ASP A  48
ARG A  94
THR A 178
 None
NAP  A 523 (-3.7A)
None
None
None
 0.33A 4eilD-2h2qA:
40.6		 4eilD-2h2qA:
44.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hih LIPASE 46 KDA FORM

(Staphylococcus
hyicus) 		no annotation 5 VAL A  33
ALA A  35
SER A  65
PHE A  26
VAL A  30
 None
 1.48A 4eilD-2hihA:
undetectable		 4eilD-2hihA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE

(Vibrio cholerae) 		PF00571
(CBS) 		5 VAL A 130
ASP A 144
PHE A 145
VAL A 107
THR A  28
 None
 1.48A 4eilD-2o16A:
undetectable		 4eilD-2o16A:
14.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		6 VAL A   9
ALA A  11
ASP A  32
SER A  37
ARG A  70
THR A 134
 MTX  A 605 ( 4.0A)
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 2.9A)
MTX  A 605 ( 3.1A)
MTX  A 605 ( 4.2A)
 0.29A 4eilD-2oipA:
44.8		 4eilD-2oipA:
44.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkq GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
B

(Spinacia
oleracea) 		PF00044
(Gp_dh_N)
PF02672
(CP12)
PF02800
(Gp_dh_C) 		5 VAL O 305
ALA O 252
ASP O 254
VAL O 307
THR O 251
 None
 1.37A 4eilD-2pkqO:
undetectable		 4eilD-2pkqO:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3w DIHYDROFOLATE
REDUCTASE

(Mycobacterium
avium) 		PF00186
(DHFR_1) 		5 VAL A   9
ALA A  11
ASP A  31
ARG A  64
THR A 121
 VG9  A1168 (-4.2A)
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 ( 3.7A)
VG9  A1168 ( 4.7A)
 0.60A 4eilD-2w3wA:
20.6		 4eilD-2w3wA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl1 PYRIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		5 VAL A 690
ALA A 669
PHE A 756
SER A 757
VAL A 691
 None
None
None
EDO  A1780 ( 4.6A)
None
 1.48A 4eilD-2wl1A:
undetectable		 4eilD-2wl1A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 VAL A 501
ASP A 460
SER A 476
PHE A 483
VAL A 500
 None
CA  A 540 (-3.0A)
None
None
None
 1.46A 4eilD-3afgA:
undetectable		 4eilD-3afgA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg8 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1) 		5 ALA A  16
ASP A  54
PHE A 116
ARG A 122
THR A 185
 RJ6  A 609 (-3.7A)
RJ6  A 609 (-3.0A)
None
None
RJ6  A 609 ( 4.5A)
 0.58A 4eilD-3dg8A:
21.5		 4eilD-3dg8A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix9 DIHYDROFOLATE
REDUCTASE

(Streptococcus
pneumoniae) 		PF00186
(DHFR_1) 		5 ALA A  10
MET A  53
ARG A  61
VAL A 100
THR A 119
 MTX  A 200 (-3.8A)
MTX  A 200 ( 4.4A)
MTX  A 200 (-2.9A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.5A)
 0.45A 4eilD-3ix9A:
20.1		 4eilD-3ix9A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3liu PUTATIVE CELL
ADHESION PROTEIN

(Parabacteroides
distasonis) 		PF06321
(P_gingi_FimA) 		5 VAL A 373
ALA A 227
PHE A 301
SER A 196
VAL A 356
 None
 1.43A 4eilD-3liuA:
undetectable		 4eilD-3liuA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN
CAPSID PROTEIN
CAPSID PROTEIN

(Triatoma virus;
Triatoma virus;
Triatoma virus) 		PF08762
(CRPV_capsid)
PF00073
(Rhv)
PF00073
(Rhv) 		5 PHE A 112
SER A 184
PHE C  46
VAL B 202
THR B 211
 None
 1.42A 4eilD-3napA:
undetectable		 4eilD-3napA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT
6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris;
Komagataella
pastoris) 		PF00365
(PFK)
PF00365
(PFK) 		5 VAL A 865
ALA B 834
PHE B 722
SER B 721
VAL B 728
 None
 1.39A 4eilD-3opyA:
undetectable		 4eilD-3opyA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnz PHOSPHOTRIESTERASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF02126
(PTE) 		5 VAL A 135
ALA A 150
PHE A 328
VAL A 136
THR A  92
 None
None
None
None
KCX  A 154 ( 4.4A)
 1.48A 4eilD-3pnzA:
undetectable		 4eilD-3pnzA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg9 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
brucei) 		PF00186
(DHFR_1) 		5 VAL A  32
ALA A  34
ASP A  54
ARG A 100
THR A 184
 WRA  A 602 (-4.3A)
WRA  A 602 (-3.9A)
WRA  A 602 (-2.9A)
None
WRA  A 602 (-4.2A)
 0.33A 4eilD-3rg9A:
21.3		 4eilD-3rg9A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg9 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
brucei) 		PF00186
(DHFR_1) 		5 VAL A  32
ASP A  54
PHE A  94
ARG A 100
THR A 184
 WRA  A 602 (-4.3A)
WRA  A 602 (-2.9A)
WRA  A 602 (-3.9A)
None
WRA  A 602 (-4.2A)
 0.66A 4eilD-3rg9A:
21.3		 4eilD-3rg9A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vco DIHYDROFOLATE
REDUCTASE

(Schistosoma
mansoni) 		PF00186
(DHFR_1) 		5 VAL A   6
ALA A   8
ASP A  28
ARG A  67
THR A 133
 None
 0.33A 4eilD-3vcoA:
20.0		 4eilD-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vco DIHYDROFOLATE
REDUCTASE

(Schistosoma
mansoni) 		PF00186
(DHFR_1) 		5 VAL A   6
ALA A   8
PHE A  61
ARG A  67
THR A 133
 None
 0.65A 4eilD-3vcoA:
20.0		 4eilD-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1

(Homo sapiens) 		PF00753
(Lactamase_B)
PF12706
(Lactamase_B_2) 		5 VAL A  24
ASP A 353
PHE A 354
VAL A  25
THR A  10
 None
 1.50A 4eilD-3zwfA:
undetectable		 4eilD-3zwfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE

(Trypanosoma
brucei) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ALA A 430
ASP A 427
PHE A 338
VAL A 334
THR A 310
 None
 1.49A 4eilD-4bi9A:
undetectable		 4eilD-4bi9A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9d POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Escherichia
coli) 		PF01522
(Polysacc_deac_1)
PF14883
(GHL13) 		5 VAL A  50
ALA A 279
PHE A 272
SER A  53
VAL A 109
 None
None
None
ACY  A 702 ( 4.9A)
None
 1.25A 4eilD-4f9dA:
undetectable		 4eilD-4f9dA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre IMMUNOGLOBULIN
GAMMA-2A, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 116
ALA B  89
PHE B  68
SER B  84
VAL B 114
 None
 1.45A 4eilD-4jreB:
undetectable		 4eilD-4jreB:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7v DIHYDROFOLATE
REDUCTASE

(Enterococcus
faecalis) 		PF00186
(DHFR_1) 		5 ALA A   7
ASP A  27
MET A  50
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.0A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.69A 4eilD-4m7vA:
19.4		 4eilD-4m7vA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Mycobacterium
tuberculosis) 		PF01497
(Peripla_BP_2) 		5 ALA A  70
ASP A  43
PHE A 282
SER A 283
VAL A 290
 None
 1.43A 4eilD-4pm4A:
undetectable		 4eilD-4pm4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE

(Pectobacterium
atrosepticum) 		PF02275
(CBAH) 		5 VAL A 125
ASP A 155
SER A 175
MET A 181
THR A 120
 None
 1.46A 4eilD-4wl2A:
undetectable		 4eilD-4wl2A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esp I-PANMI

(Podospora
anserina) 		PF00961
(LAGLIDADG_1) 		5 VAL A 270
PHE A 180
SER A 199
MET A 294
VAL A 269
 None
 1.45A 4eilD-5espA:
undetectable		 4eilD-5espA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 VAL D 401
ASP D 477
SER D 471
PHE D 488
VAL D 405
 None
 1.24A 4eilD-5fl7D:
undetectable		 4eilD-5fl7D:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guj DNA PRIMASE

(Bacillus
subtilis) 		PF08275
(Toprim_N)
PF10410
(DnaB_bind)
PF13155
(Toprim_2) 		5 VAL A 219
ALA A 187
SER A 222
VAL A 218
THR A 239
 None
 1.50A 4eilD-5gujA:
undetectable		 4eilD-5gujA:
18.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Toxoplasma
gondii) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		10 VAL A   8
ALA A  10
ASP A  31
PHE A  32
SER A  36
MET A  87
PHE A  91
ARG A  97
VAL A 151
THR A 172
 73X  A 704 (-3.7A)
73X  A 704 (-4.0A)
73X  A 704 (-2.8A)
73X  A 704 (-4.7A)
None
73X  A 704 (-4.8A)
73X  A 704 ( 4.2A)
None
73X  A 704 ( 3.8A)
73X  A 704 (-4.2A)
 0.33A 4eilD-5t0lA:
54.4		 4eilD-5t0lA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x15 PUTATIVE TRANSFERASE

(Streptomyces
coelicolor) 		PF03737
(RraA-like) 		5 VAL A 214
ALA A 208
SER A  66
ARG A  62
VAL A 215
 None
 1.42A 4eilD-5x15A:
undetectable		 4eilD-5x15A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Mus musculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		5 VAL A 435
ALA A 438
ASP A 442
SER A 278
VAL A 239
 None
 1.31A 4eilD-5xa1A:
undetectable		 4eilD-5xa1A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Staphylococcus
aureus) 		no annotation 5 VAL A 482
ASP A 228
SER A 234
VAL A 246
THR A 222
 None
 1.44A 4eilD-5yh5A:
undetectable		 4eilD-5yh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbo C-6'
AMINOTRANSFERASE

(Micromonospora
echinospora) 		no annotation 5 ALA A 393
ASP A 180
PHE A 157
PHE A 155
ARG A 402
 None
 1.34A 4eilD-6cboA:
undetectable		 4eilD-6cboA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans) 		no annotation 5 VAL A  70
ALA A  72
PHE A 242
VAL A 133
THR A  73
 None
None
GOL  A 503 (-4.0A)
None
None
 1.45A 4eilD-6enoA:
undetectable		 4eilD-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2x PROTEIN TYROSINE
KINASE A

(Mycobacterium
tuberculosis) 		no annotation 5 VAL A 258
ALA A 280
PHE A 267
ARG A 241
VAL A 257
 None
 1.44A 4eilD-6f2xA:
2.3		 4eilD-6f2xA:
undetectable