SIMILAR PATTERNS OF AMINO ACIDS FOR 4EF3_A_CUA1003

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  60
HIS A 106
HIS A 448
HIS A 450
HIS A 506
 CU  A 557 ( 3.1A)
CU  A 555 (-3.3A)
CU  A 557 ( 3.2A)
CU  A 555 ( 3.2A)
CU  A 555 (-3.1A)
 0.29A 4ef3A-1asoA:
28.9		 4ef3A-1asoA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 448
HIS A 508
HIS A  60
HIS A  62
HIS A 104
 CU  A 557 ( 3.2A)
CU  A 556 (-3.3A)
CU  A 557 ( 3.1A)
CU  A 556 ( 3.0A)
CU  A 556 (-3.1A)
 0.66A 4ef3A-1asoA:
28.9		 4ef3A-1asoA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A 111
HIS A 398
HIS A 400
HIS A 452
 CU  A1502 (-3.1A)
CU  A1501 (-3.4A)
CU  A1502 ( 3.1A)
CU  A1501 ( 3.2A)
CU  A1501 (-3.3A)
 0.22A 4ef3A-1gycA:
32.1		 4ef3A-1gycA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 398
HIS A 454
HIS A  64
HIS A  66
HIS A 109
 CU  A1502 ( 3.1A)
CU  A1500 (-3.3A)
CU  A1502 (-3.1A)
CU  A1500 ( 3.2A)
CU  A1500 (-3.3A)
 0.58A 4ef3A-1gycA:
32.1		 4ef3A-1gycA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 111
HIS A  64
HIS A 453
HIS A 109
HIS A  66
 CU  A 702 (-3.2A)
CU  A 703 (-4.7A)
CU  A 703 (-3.3A)
CU  A 703 (-3.2A)
CU  A 703 (-3.0A)
 1.39A 4ef3A-1hfuA:
31.8		 4ef3A-1hfuA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 399
HIS A 453
HIS A  64
HIS A  66
HIS A 109
 CU  A 702 ( 3.7A)
CU  A 703 (-3.3A)
CU  A 703 (-4.7A)
CU  A 703 (-3.0A)
CU  A 703 (-3.2A)
 0.88A 4ef3A-1hfuA:
31.8		 4ef3A-1hfuA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 101
HIS A 163
HIS A 978
HIS A 980
HIS A1020
 CU  A1052 (-3.2A)
CU  A1050 (-3.3A)
CU  A1052 ( 3.2A)
CU  A1050 (-3.0A)
CU  A1050 (-3.2A)
 0.59A 4ef3A-1kcwA:
13.9		 4ef3A-1kcwA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 978
HIS A1022
HIS A 101
HIS A 103
HIS A 161
 CU  A1052 ( 3.2A)
CU  A1051 (-3.2A)
CU  A1052 (-3.2A)
CU  A1051 (-3.3A)
CU  A1051 (-3.3A)
 0.38A 4ef3A-1kcwA:
13.9		 4ef3A-1kcwA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 980
HIS A 978
HIS A 161
HIS A 101
HIS A 103
 CU  A1050 (-3.0A)
CU  A1052 ( 3.2A)
CU  A1051 (-3.3A)
CU  A1052 (-3.2A)
CU  A1051 (-3.3A)
 1.35A 4ef3A-1kcwA:
13.9		 4ef3A-1kcwA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A1020
HIS A 978
HIS A 163
HIS A 980
HIS A 101
 CU  A1050 (-3.2A)
CU  A1052 ( 3.2A)
CU  A1050 (-3.3A)
CU  A1050 (-3.0A)
CU  A1052 (-3.2A)
 1.39A 4ef3A-1kcwA:
13.9		 4ef3A-1kcwA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A 111
HIS A 398
HIS A 400
HIS A 452
 CU  A 503 (-3.2A)
CU  A 501 (-3.5A)
CU  A 503 ( 3.2A)
CU  A 501 ( 3.3A)
CU  A 501 (-3.4A)
 0.31A 4ef3A-1kyaA:
32.1		 4ef3A-1kyaA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 398
HIS A 454
HIS A  64
HIS A  66
HIS A 109
 CU  A 503 ( 3.2A)
CU  A 502 (-3.4A)
CU  A 503 (-3.2A)
CU  A 502 (-3.3A)
CU  A 502 (-3.7A)
 0.62A 4ef3A-1kyaA:
32.1		 4ef3A-1kyaA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 HIS A 364
HIS A 324
HIS A 173
HIS A 204
HIS A 177
 CU  A 630 (-3.0A)
CU  A 630 (-3.3A)
CU  A 629 (-3.2A)
CU  A 629 (-3.1A)
CU  A 629 (-3.2A)
 1.38A 4ef3A-1llaA:
undetectable		 4ef3A-1llaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A 111
HIS A 399
HIS A 401
HIS A 451
 CU  A1502 (-3.2A)
CU  A1501 (-3.3A)
CU  A1502 (-2.9A)
CU  A1501 ( 3.2A)
CU  A1501 (-2.9A)
 0.33A 4ef3A-1v10A:
32.2		 4ef3A-1v10A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 399
HIS A 453
HIS A  64
HIS A  66
HIS A 109
 CU  A1502 (-2.9A)
CU  A1500 (-3.4A)
CU  A1502 (-3.2A)
CU  A1500 ( 2.9A)
CU  A1500 (-3.3A)
 0.58A 4ef3A-1v10A:
32.2		 4ef3A-1v10A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  81
HIS A 128
HIS A 416
HIS A 418
HIS A 483
 CU1  A1004 (-3.3A)
CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.33A 4ef3A-1zpuA:
30.1		 4ef3A-1zpuA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 416
HIS A 485
HIS A  81
HIS A  83
HIS A 126
 CU1  A1004 (-3.2A)
CU1  A1003 (-3.4A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
 0.64A 4ef3A-1zpuA:
30.1		 4ef3A-1zpuA:
23.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 101
HIS A 143
HIS A 446
HIS A 448
HIS A 499
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.5A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.22A 4ef3A-2fqdA:
70.4		 4ef3A-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 103
HIS A 101
HIS A 499
HIS A 446
HIS A 448
 C2O  A 602 (-3.0A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 1.41A 4ef3A-2fqdA:
70.4		 4ef3A-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 446
HIS A 501
HIS A 101
HIS A 103
HIS A 141
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.4A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-3.2A)
 0.66A 4ef3A-2fqdA:
70.4		 4ef3A-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 499
HIS A 448
HIS A 141
HIS A 143
HIS A 101
 C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.2A)
C2O  A 602 (-3.5A)
C2O  A 602 (-3.9A)
 1.27A 4ef3A-2fqdA:
70.4		 4ef3A-2fqdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A 111
HIS A 398
HIS A 400
HIS A 452
 CU  A 604 ( 3.1A)
CU  A 602 (-3.2A)
CU  A 604 (-3.1A)
CU  A 602 ( 3.2A)
CU  A 602 (-3.1A)
 0.32A 4ef3A-2hzhA:
32.2		 4ef3A-2hzhA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 398
HIS A 454
HIS A  64
HIS A  66
HIS A 109
 CU  A 604 (-3.1A)
CU  A 603 (-3.3A)
CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
CU  A 603 (-3.4A)
 0.64A 4ef3A-2hzhA:
32.2		 4ef3A-2hzhA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A 111
HIS A 397
HIS A 399
HIS A 451
 CU  A 500 (-3.1A)
CU  A 501 ( 3.2A)
CU  A 500 (-3.1A)
CU  A 501 ( 3.2A)
CU  A 501 (-3.2A)
 0.29A 4ef3A-2qt6A:
32.3		 4ef3A-2qt6A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 111
HIS A  64
HIS A 453
HIS A 109
HIS A  66
 CU  A 501 ( 3.2A)
CU  A 500 (-3.1A)
CU  A 502 (-3.3A)
CU  A 502 (-3.2A)
CU  A 502 ( 3.1A)
 1.34A 4ef3A-2qt6A:
32.3		 4ef3A-2qt6A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 397
HIS A 453
HIS A  64
HIS A  66
HIS A 109
 CU  A 500 (-3.1A)
CU  A 502 (-3.3A)
CU  A 500 (-3.1A)
CU  A 502 ( 3.1A)
CU  A 502 (-3.2A)
 0.62A 4ef3A-2qt6A:
32.3		 4ef3A-2qt6A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A 111
HIS A 398
HIS A 400
HIS A 450
 CU  A 504 ( 3.1A)
CU  A 502 (-3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.2A)
CU  A 502 ( 3.3A)
 0.29A 4ef3A-2xybA:
32.2		 4ef3A-2xybA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 398
HIS A 452
HIS A  64
HIS A  66
HIS A 109
 CU  A 504 (-3.1A)
CU  A 503 ( 3.3A)
CU  A 504 ( 3.1A)
CU  A 503 (-3.1A)
CU  A 503 ( 3.2A)
 0.61A 4ef3A-2xybA:
32.2		 4ef3A-2xybA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  94
HIS A 136
HIS A 401
HIS A 403
HIS A 456
 CU  A 703 (-3.0A)
CU  A 701 (-3.2A)
CU  A 703 (-3.4A)
CU  A 701 ( 3.1A)
CU  A 701 (-3.3A)
 0.37A 4ef3A-3abgA:
42.2		 4ef3A-3abgA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 401
HIS A 458
HIS A  94
HIS A  96
HIS A 134
 CU  A 703 (-3.4A)
CU  A 702 (-3.5A)
CU  A 703 (-3.0A)
CU  A 702 ( 3.2A)
CU  A 702 (-3.1A)
 0.65A 4ef3A-3abgA:
42.2		 4ef3A-3abgA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 458
HIS A 401
HIS A 136
HIS A 456
HIS A 403
 CU  A 702 (-3.5A)
CU  A 703 (-3.4A)
CU  A 701 (-3.2A)
CU  A 701 (-3.3A)
CU  A 701 ( 3.1A)
 1.28A 4ef3A-3abgA:
42.2		 4ef3A-3abgA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  92
HIS A 134
HIS A 394
HIS A 396
HIS A 459
 CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.17A 4ef3A-3aw5A:
45.2		 4ef3A-3aw5A:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 394
HIS A 461
HIS A  92
HIS A  94
HIS A 132
 CU  A 703 ( 3.0A)
C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
 0.67A 4ef3A-3aw5A:
45.2		 4ef3A-3aw5A:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  93
HIS A 140
HIS A 434
HIS A 436
HIS A 502
 CU  A 604 (-3.1A)
CU  A 602 ( 3.3A)
CU  A 604 (-3.2A)
CU  A 602 (-3.2A)
CU  A 602 ( 3.2A)
 0.27A 4ef3A-3dkhA:
28.8		 4ef3A-3dkhA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 434
HIS A 504
HIS A  93
HIS A  95
HIS A 138
 CU  A 604 (-3.2A)
CU  A 603 ( 3.3A)
CU  A 604 (-3.1A)
CU  A 603 ( 3.2A)
CU  A 603 ( 3.3A)
 0.65A 4ef3A-3dkhA:
28.8		 4ef3A-3dkhA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 161
HIS A 203
HIS A 527
HIS A 529
HIS A 602
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.25A 4ef3A-3gyrA:
37.2		 4ef3A-3gyrA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 527
HIS A 604
HIS A 161
HIS A 163
HIS A 201
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
C2O  A1002 (-3.7A)
 0.71A 4ef3A-3gyrA:
37.2		 4ef3A-3gyrA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A 111
HIS A 403
HIS A 405
HIS A 455
 CU  A 602 (-3.1A)
CU  A 603 (-3.2A)
CU  A 602 (-3.0A)
CU  A 603 ( 3.0A)
CU  A 603 (-3.1A)
 0.35A 4ef3A-3kw7A:
31.8		 4ef3A-3kw7A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  66
HIS A  64
HIS A 455
HIS A 403
HIS A 405
 CU  A 604 ( 2.9A)
CU  A 602 (-3.1A)
CU  A 603 (-3.1A)
CU  A 602 (-3.0A)
CU  A 603 ( 3.0A)
 1.42A 4ef3A-3kw7A:
31.8		 4ef3A-3kw7A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 109
HIS A  66
HIS A 455
HIS A 457
HIS A 403
 CU  A 604 (-3.2A)
CU  A 604 ( 2.9A)
CU  A 603 (-3.1A)
CU  A 604 (-3.1A)
CU  A 602 (-3.0A)
 1.25A 4ef3A-3kw7A:
31.8		 4ef3A-3kw7A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 403
HIS A 457
HIS A  64
HIS A  66
HIS A 109
 CU  A 602 (-3.0A)
CU  A 604 (-3.1A)
CU  A 602 (-3.1A)
CU  A 604 ( 2.9A)
CU  A 604 (-3.2A)
 0.62A 4ef3A-3kw7A:
31.8		 4ef3A-3kw7A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 405
HIS A 403
HIS A 109
HIS A  64
HIS A  66
 CU  A 603 ( 3.0A)
CU  A 602 (-3.0A)
CU  A 604 (-3.2A)
CU  A 602 (-3.1A)
CU  A 604 ( 2.9A)
 1.43A 4ef3A-3kw7A:
31.8		 4ef3A-3kw7A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 455
HIS A 405
HIS A 109
HIS A 111
HIS A  64
 CU  A 603 (-3.1A)
CU  A 603 ( 3.0A)
CU  A 604 (-3.2A)
CU  A 603 (-3.2A)
CU  A 602 (-3.1A)
 1.23A 4ef3A-3kw7A:
31.8		 4ef3A-3kw7A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  94
HIS A 141
HIS A 435
HIS A 437
HIS A 503
 CU  A 604 ( 3.1A)
CU  A 602 ( 3.3A)
CU  A 604 ( 3.3A)
CU  A 602 (-3.3A)
CU  A 602 ( 3.3A)
 0.30A 4ef3A-3ppsA:
28.4		 4ef3A-3ppsA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 435
HIS A 505
HIS A  94
HIS A  96
HIS A 139
 CU  A 604 ( 3.3A)
CU  A 603 ( 3.3A)
CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
CU  A 603 ( 3.1A)
 0.65A 4ef3A-3ppsA:
28.4		 4ef3A-3ppsA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A 111
HIS A 398
HIS A 400
HIS A 452
 CU  A1502 ( 3.0A)
CU  A1500 (-3.2A)
CU  A1502 ( 2.9A)
CU  A1500 ( 3.2A)
CU  A1500 (-3.1A)
 0.41A 4ef3A-3pxlA:
32.3		 4ef3A-3pxlA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 111
HIS A  64
HIS A 454
HIS A 109
HIS A  66
 CU  A1500 (-3.2A)
CU  A1502 ( 3.0A)
CU  A1501 (-3.3A)
CU  A1501 (-3.2A)
CU  A1501 ( 3.0A)
 1.35A 4ef3A-3pxlA:
32.3		 4ef3A-3pxlA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 398
HIS A 454
HIS A  64
HIS A  66
HIS A 109
 CU  A1502 ( 2.9A)
CU  A1501 (-3.3A)
CU  A1502 ( 3.0A)
CU  A1501 ( 3.0A)
CU  A1501 (-3.2A)
 0.66A 4ef3A-3pxlA:
32.3		 4ef3A-3pxlA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  65
HIS A 112
HIS A 400
HIS A 402
HIS A 452
 CU  A 504 (-3.1A)
CU  A 503 (-3.4A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.2A)
CU  A 503 ( 3.3A)
 0.23A 4ef3A-3t6wA:
33.1		 4ef3A-3t6wA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 110
HIS A  67
HIS A 452
HIS A 454
HIS A 400
 CU  A 502 ( 3.5A)
CU  A 502 (-3.3A)
CU  A 503 ( 3.3A)
OXY  A 511 ( 3.2A)
CU  A 504 ( 3.1A)
 1.24A 4ef3A-3t6wA:
33.1		 4ef3A-3t6wA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 400
HIS A 454
HIS A  65
HIS A  67
HIS A 110
 CU  A 504 ( 3.1A)
OXY  A 511 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
 0.64A 4ef3A-3t6wA:
33.1		 4ef3A-3t6wA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 402
HIS A 400
HIS A 110
HIS A  65
HIS A  67
 CU  A 503 ( 3.2A)
CU  A 504 ( 3.1A)
CU  A 502 ( 3.5A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
 1.43A 4ef3A-3t6wA:
33.1		 4ef3A-3t6wA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 452
HIS A 402
HIS A 110
HIS A 112
HIS A  65
 CU  A 503 ( 3.3A)
CU  A 503 ( 3.2A)
CU  A 502 ( 3.5A)
CU  A 503 (-3.4A)
CU  A 504 (-3.1A)
 1.26A 4ef3A-3t6wA:
33.1		 4ef3A-3t6wA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  87
HIS A 133
HIS A 429
HIS A 431
HIS A 488
 CU  A 602 ( 4.7A)
CU  A 602 (-3.3A)
CU  A 602 (-3.6A)
CU  A 602 (-3.1A)
CU  A 602 (-3.1A)
 0.49A 4ef3A-3v9eA:
29.7		 4ef3A-3v9eA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  89
HIS A  87
HIS A 488
HIS A 429
HIS A 431
 CU  A 603 (-2.9A)
CU  A 602 ( 4.7A)
CU  A 602 (-3.1A)
CU  A 602 (-3.6A)
CU  A 602 (-3.1A)
 1.34A 4ef3A-3v9eA:
29.7		 4ef3A-3v9eA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 429
HIS A 490
HIS A  87
HIS A  89
HIS A 131
 CU  A 602 (-3.6A)
CU  A 603 (-3.5A)
CU  A 602 ( 4.7A)
CU  A 603 (-2.9A)
CU  A 603 (-3.2A)
 0.69A 4ef3A-3v9eA:
29.7		 4ef3A-3v9eA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 490
HIS A 429
HIS A 133
HIS A 488
HIS A 431
 CU  A 603 (-3.5A)
CU  A 602 (-3.6A)
CU  A 602 (-3.3A)
CU  A 602 (-3.1A)
CU  A 602 (-3.1A)
 1.32A 4ef3A-3v9eA:
29.7		 4ef3A-3v9eA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  85
HIS A 132
HIS A 420
HIS A 422
HIS A 474
 CU  A 614 (-3.1A)
CU  A 616 (-3.2A)
CU  A 614 (-3.1A)
CU  A 616 ( 3.2A)
CU  A 616 (-3.2A)
 0.25A 4ef3A-3x1bA:
32.3		 4ef3A-3x1bA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 420
HIS A 476
HIS A  85
HIS A  87
HIS A 130
 CU  A 614 (-3.1A)
CU  A 615 (-3.2A)
CU  A 614 (-3.1A)
CU  A 615 ( 3.1A)
CU  A 615 (-3.2A)
 0.62A 4ef3A-3x1bA:
32.3		 4ef3A-3x1bA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 139
HIS A 182
HIS A 442
HIS A 444
HIS A 494
 CU  A 604 ( 3.0A)
CU  A 603 ( 2.8A)
CU  A 604 ( 3.0A)
CU  A 603 (-3.1A)
CU  A 603 ( 3.1A)
 0.32A 4ef3A-3zx1A:
44.5		 4ef3A-3zx1A:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 141
HIS A 139
HIS A 494
HIS A 442
HIS A 444
 CU  A 602 (-3.0A)
CU  A 604 ( 3.0A)
CU  A 603 ( 3.1A)
CU  A 604 ( 3.0A)
CU  A 603 (-3.1A)
 1.30A 4ef3A-3zx1A:
44.5		 4ef3A-3zx1A:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 442
HIS A 496
HIS A 139
HIS A 141
HIS A 180
 CU  A 604 ( 3.0A)
CU  A 602 ( 3.3A)
CU  A 604 ( 3.0A)
CU  A 602 (-3.0A)
CU  A 602 ( 3.1A)
 0.61A 4ef3A-3zx1A:
44.5		 4ef3A-3zx1A:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 496
HIS A 442
HIS A 182
HIS A 494
HIS A 444
 CU  A 602 ( 3.3A)
CU  A 604 ( 3.0A)
CU  A 603 ( 2.8A)
CU  A 603 ( 3.1A)
CU  A 603 (-3.1A)
 1.28A 4ef3A-3zx1A:
44.5		 4ef3A-3zx1A:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 105
HIS A 155
HIS A 422
HIS A 424
HIS A 491
 CU  A 604 ( 3.1A)
CU  A 603 ( 3.2A)
CU  A 604 ( 3.1A)
CU  A 603 (-3.2A)
CU  A 603 ( 3.1A)
 0.17A 4ef3A-4akoA:
44.1		 4ef3A-4akoA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 107
HIS A 105
HIS A 491
HIS A 422
HIS A 424
 CU  A 602 (-3.1A)
CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
CU  A 604 ( 3.1A)
CU  A 603 (-3.2A)
 1.37A 4ef3A-4akoA:
44.1		 4ef3A-4akoA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 422
HIS A 493
HIS A 105
HIS A 107
HIS A 153
 CU  A 604 ( 3.1A)
CU  A 602 ( 3.2A)
CU  A 604 ( 3.1A)
CU  A 602 (-3.1A)
CU  A 602 ( 3.2A)
 0.64A 4ef3A-4akoA:
44.1		 4ef3A-4akoA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 493
HIS A 422
HIS A 155
HIS A 491
HIS A 424
 CU  A 602 ( 3.2A)
CU  A 604 ( 3.1A)
CU  A 603 ( 3.2A)
CU  A 603 ( 3.1A)
CU  A 603 (-3.2A)
 1.28A 4ef3A-4akoA:
44.1		 4ef3A-4akoA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 HIS B3106
HIS B3075
HIS B2946
HIS B2974
HIS B2965
 CUO  B9008 (-3.3A)
CUO  B9008 (-2.8A)
CUO  B9008 (-3.1A)
CUO  B9008 (-2.9A)
CUO  B9008 (-3.2A)
 1.30A 4ef3A-4bedB:
undetectable		 4ef3A-4bedB:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7h PEROXIDE STRESS
SENSING REGULATOR

(Streptococcus
pyogenes) 		PF01475
(FUR) 		5 HIS A   6
HIS A  99
HIS A  19
HIS A   4
HIS A  97
 NI  A 201 (-3.6A)
NI  A 201 (-3.5A)
NI  A 201 (-3.5A)
NI  A 201 (-3.6A)
NI  A 201 (-3.6A)
 1.29A 4ef3A-4i7hA:
undetectable		 4ef3A-4i7hA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A 111
HIS A 397
HIS A 399
HIS A 449
 CU  A 504 ( 2.8A)
CU  A 501 (-3.2A)
CU  A 504 (-2.7A)
CU  A 501 ( 3.2A)
CU  A 501 (-3.1A)
 0.45A 4ef3A-4jhvA:
32.0		 4ef3A-4jhvA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 397
HIS A 451
HIS A  64
HIS A  66
HIS A 109
 CU  A 504 (-2.7A)
CU  A 502 (-3.3A)
CU  A 504 ( 2.8A)
CU  A 502 ( 3.1A)
CU  A 502 (-3.2A)
 0.69A 4ef3A-4jhvA:
32.0		 4ef3A-4jhvA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 399
HIS A 397
HIS A 109
HIS A  64
HIS A  66
 CU  A 501 ( 3.2A)
CU  A 504 (-2.7A)
CU  A 502 (-3.2A)
CU  A 504 ( 2.8A)
CU  A 502 ( 3.1A)
 1.43A 4ef3A-4jhvA:
32.0		 4ef3A-4jhvA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		5 HIS A 157
HIS A 156
HIS A 297
HIS A 298
HIS A 294
 ZN  A 401 (-3.3A)
ZN  A 402 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.4A)
ZN  A 402 (-3.1A)
 1.22A 4ef3A-4ymkA:
undetectable		 4ef3A-4ymkA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		5 HIS A 298
HIS A 297
HIS A 156
HIS A 157
HIS A 153
 ZN  A 402 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 1.10A 4ef3A-4ymkA:
undetectable		 4ef3A-4ymkA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 HIS A 272
HIS A 271
HIS A 345
HIS A 349
HIS A 330
 ZN  A 402 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.3A)
 1.26A 4ef3A-4zr0A:
undetectable		 4ef3A-4zr0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 HIS A 272
HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 402 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
 1.19A 4ef3A-4zr0A:
undetectable		 4ef3A-4zr0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 HIS A 349
HIS A 348
HIS A 271
HIS A 272
HIS A 268
 ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.4A)
ZN  A 402 (-3.5A)
 1.25A 4ef3A-4zr0A:
undetectable		 4ef3A-4zr0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 HIS A 244
HIS A 249
HIS A 349
HIS A 348
HIS A 272
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
 1.25A 4ef3A-4zr1A:
undetectable		 4ef3A-4zr1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 HIS A 244
HIS A 268
HIS A 345
HIS A 348
HIS A 349
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
 1.39A 4ef3A-4zr1A:
undetectable		 4ef3A-4zr1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 HIS A 272
HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 402 (-3.5A)
ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 1.25A 4ef3A-4zr1A:
undetectable		 4ef3A-4zr1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 HIS A 349
HIS A 348
HIS A 271
HIS A 272
HIS A 268
 ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 ( 3.4A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
 1.28A 4ef3A-4zr1A:
undetectable		 4ef3A-4zr1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 5 HIS A 302
HIS A 301
HIS A 160
HIS A 161
HIS A 157
 ZN  A 402 (-3.5A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 1.25A 4ef3A-4zyoA:
undetectable		 4ef3A-4zyoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A 111
HIS A 398
HIS A 400
HIS A 450
 CU  A 509 (-3.2A)
CU  A 507 ( 3.3A)
CU  A 509 ( 3.1A)
CU  A 507 ( 3.1A)
CU  A 507 (-3.2A)
 0.21A 4ef3A-5ehfA:
33.1		 4ef3A-5ehfA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  66
HIS A  64
HIS A 450
HIS A 398
HIS A 400
 CU  A 508 ( 3.1A)
CU  A 509 (-3.2A)
CU  A 507 (-3.2A)
CU  A 509 ( 3.1A)
CU  A 507 ( 3.1A)
 1.40A 4ef3A-5ehfA:
33.1		 4ef3A-5ehfA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 109
HIS A  66
HIS A 450
HIS A 452
HIS A 398
 CU  A 508 (-3.3A)
CU  A 508 ( 3.1A)
CU  A 507 (-3.2A)
CU  A 508 (-3.2A)
CU  A 509 ( 3.1A)
 1.21A 4ef3A-5ehfA:
33.1		 4ef3A-5ehfA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 398
HIS A 452
HIS A  64
HIS A  66
HIS A 109
 CU  A 509 ( 3.1A)
CU  A 508 (-3.2A)
CU  A 509 (-3.2A)
CU  A 508 ( 3.1A)
CU  A 508 (-3.3A)
 0.59A 4ef3A-5ehfA:
33.1		 4ef3A-5ehfA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 400
HIS A 398
HIS A 109
HIS A  64
HIS A  66
 CU  A 507 ( 3.1A)
CU  A 509 ( 3.1A)
CU  A 508 (-3.3A)
CU  A 509 (-3.2A)
CU  A 508 ( 3.1A)
 1.44A 4ef3A-5ehfA:
33.1		 4ef3A-5ehfA:
23.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  95
HIS A 137
HIS A 396
HIS A 398
HIS A 444
 CU  A1463 (-4.1A)
CU  A1463 (-3.3A)
CU  A1463 ( 4.8A)
CU  A1463 (-2.9A)
CU  A1463 (-3.0A)
 0.55A 4ef3A-5g3fA:
48.0		 4ef3A-5g3fA:
33.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 396
HIS A 446
HIS A  95
HIS A  97
HIS A 135
 CU  A1463 ( 4.8A)
CU  A1465 (-3.3A)
CU  A1463 (-4.1A)
CU  A1465 (-3.1A)
CU  A1465 (-3.2A)
 0.70A 4ef3A-5g3fA:
48.0		 4ef3A-5g3fA:
33.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 108
HIS A 154
HIS A 451
HIS A 453
HIS A 515
 CU  A 603 ( 3.1A)
CU  A 602 ( 3.4A)
CU  A 603 (-2.8A)
CU  A 602 (-3.1A)
CU  A 602 ( 3.2A)
 0.30A 4ef3A-5lm8A:
29.5		 4ef3A-5lm8A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 451
HIS A 517
HIS A 108
HIS A 110
HIS A 152
 CU  A 603 (-2.8A)
CU  A 601 ( 3.5A)
CU  A 603 ( 3.1A)
CU  A 601 (-2.9A)
CU  A 601 ( 3.2A)
 0.63A 4ef3A-5lm8A:
29.5		 4ef3A-5lm8A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  65
HIS A 112
HIS A 400
HIS A 402
HIS A 452
 CU  A 503 (-3.1A)
CU  A 501 (-3.1A)
CU  A 503 ( 3.1A)
CU  A 501 (-3.2A)
CU  A 501 ( 3.0A)
 0.21A 4ef3A-5mewA:
32.6		 4ef3A-5mewA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 400
HIS A 454
HIS A  65
HIS A  67
HIS A 110
 CU  A 503 ( 3.1A)
CU  A 502 ( 3.2A)
CU  A 503 (-3.1A)
CU  A 502 ( 2.9A)
CU  A 502 (-3.1A)
 0.61A 4ef3A-5mewA:
32.6		 4ef3A-5mewA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 HIS A 101
HIS A 162
HIS A 972
HIS A 974
HIS A1014
 CU  A1105 (-3.1A)
CU  A1101 (-3.3A)
CU  A1105 (-3.3A)
CU  A1101 ( 3.2A)
CU  A1101 (-3.2A)
 0.44A 4ef3A-5n4lA:
25.4		 4ef3A-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 HIS A 972
HIS A1016
HIS A 101
HIS A 103
HIS A 160
 CU  A1105 (-3.3A)
CU  A1104 (-3.1A)
CU  A1105 (-3.1A)
CU  A1104 ( 3.5A)
CU  A1104 (-3.6A)
 0.57A 4ef3A-5n4lA:
25.4		 4ef3A-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 HIS A 974
HIS A 972
HIS A 160
HIS A 101
HIS A 103
 CU  A1101 ( 3.2A)
CU  A1105 (-3.3A)
CU  A1104 (-3.6A)
CU  A1105 (-3.1A)
CU  A1104 ( 3.5A)
 1.40A 4ef3A-5n4lA:
25.4		 4ef3A-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 HIS A1014
HIS A 972
HIS A 162
HIS A 974
HIS A 101
 CU  A1101 (-3.2A)
CU  A1105 (-3.3A)
CU  A1101 (-3.3A)
CU  A1101 ( 3.2A)
CU  A1105 (-3.1A)
 1.39A 4ef3A-5n4lA:
25.4		 4ef3A-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 5 HIS A  91
HIS A 133
HIS A 437
HIS A 439
HIS A 489
 EDO  A 602 ( 4.5A)
EDO  A 602 (-4.1A)
None
EDO  A 602 (-3.8A)
None
 0.59A 4ef3A-6evgA:
53.2		 4ef3A-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 5 HIS A 437
HIS A 491
HIS A  91
HIS A  93
HIS A 131
 None
None
EDO  A 602 ( 4.5A)
None
None
 0.65A 4ef3A-6evgA:
53.2		 4ef3A-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 5 HIS A 439
HIS A 437
HIS A 131
HIS A  91
HIS A  93
 EDO  A 602 (-3.8A)
None
None
EDO  A 602 ( 4.5A)
None
 1.42A 4ef3A-6evgA:
53.2		 4ef3A-6evgA:
undetectable