SIMILAR PATTERNS OF AMINO ACIDS FOR 4EF3_A_CUA1002_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  62
HIS A 104
HIS A 448
HIS A 508
 CU  A 556 ( 3.0A)
CU  A 556 (-3.1A)
CU  A 557 ( 3.2A)
CU  A 556 (-3.3A)
 0.26A 4ef3A-1asoA:
28.9		 4ef3A-1asoA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 450
HIS A 506
HIS A  60
HIS A 106
 CU  A 555 ( 3.2A)
CU  A 555 (-3.1A)
CU  A 557 ( 3.1A)
CU  A 555 (-3.3A)
 0.65A 4ef3A-1asoA:
28.9		 4ef3A-1asoA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
HIS A 109
HIS A 398
HIS A 454
 CU  A1500 ( 3.2A)
CU  A1500 (-3.3A)
CU  A1502 ( 3.1A)
CU  A1500 (-3.3A)
 0.26A 4ef3A-1gycA:
32.1		 4ef3A-1gycA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 400
HIS A 452
HIS A  64
HIS A 111
 CU  A1501 ( 3.2A)
CU  A1501 (-3.3A)
CU  A1502 (-3.1A)
CU  A1501 (-3.4A)
 0.66A 4ef3A-1gycA:
32.1		 4ef3A-1gycA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 344
HIS A 348
HIS A 224
HIS A 384
 CU  A 666 (-3.1A)
CU  A 666 (-3.8A)
CU  A 665 (-3.5A)
CU  A 666 (-3.4A)
 1.23A 4ef3A-1hcyA:
undetectable		 4ef3A-1hcyA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
HIS A 109
HIS A 399
HIS A 453
 CU  A 703 (-3.0A)
CU  A 703 (-3.2A)
CU  A 702 ( 3.7A)
CU  A 703 (-3.3A)
 0.77A 4ef3A-1hfuA:
31.7		 4ef3A-1hfuA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 401
HIS A 451
HIS A  64
HIS A 111
 CU  A 702 (-3.2A)
CU  A 702 (-3.2A)
CU  A 703 (-4.7A)
CU  A 702 (-3.2A)
 0.67A 4ef3A-1hfuA:
31.7		 4ef3A-1hfuA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 453
HIS A 399
HIS A 109
HIS A  66
 CU  A 703 (-3.3A)
CU  A 702 ( 3.7A)
CU  A 703 (-3.2A)
CU  A 703 (-3.0A)
 1.12A 4ef3A-1hfuA:
31.7		 4ef3A-1hfuA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 103
HIS A 161
HIS A 978
HIS A1022
 CU  A1051 (-3.3A)
CU  A1051 (-3.3A)
CU  A1052 ( 3.2A)
CU  A1051 (-3.2A)
 0.61A 4ef3A-1kcwA:
13.9		 4ef3A-1kcwA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krm ADENOSINE DEAMINASE

(Bos taurus) 		PF00962
(A_deaminase) 		4 HIS A  12
HIS A  14
HIS A 235
HIS A 211
 ZN  A 501 ( 3.3A)
PRH  A 401 ( 3.0A)
PRH  A 401 (-4.0A)
ZN  A 501 ( 3.4A)
 1.04A 4ef3A-1krmA:
undetectable		 4ef3A-1krmA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
HIS A 109
HIS A 398
HIS A 454
 CU  A 502 (-3.3A)
CU  A 502 (-3.7A)
CU  A 503 ( 3.2A)
CU  A 502 (-3.4A)
 0.30A 4ef3A-1kyaA:
32.2		 4ef3A-1kyaA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 400
HIS A 452
HIS A  64
HIS A 111
 CU  A 501 ( 3.3A)
CU  A 501 (-3.4A)
CU  A 503 (-3.2A)
CU  A 501 (-3.5A)
 0.69A 4ef3A-1kyaA:
32.2		 4ef3A-1kyaA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
HIS A 109
HIS A 399
HIS A 453
 CU  A1500 ( 2.9A)
CU  A1500 (-3.3A)
CU  A1502 (-2.9A)
CU  A1500 (-3.4A)
 0.23A 4ef3A-1v10A:
32.2		 4ef3A-1v10A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 401
HIS A 451
HIS A  64
HIS A 111
 CU  A1501 ( 3.2A)
CU  A1501 (-2.9A)
CU  A1502 (-3.2A)
CU  A1501 (-3.3A)
 0.71A 4ef3A-1v10A:
32.2		 4ef3A-1v10A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  83
HIS A 126
HIS A 416
HIS A 485
 CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
CU1  A1004 (-3.2A)
CU1  A1003 (-3.4A)
 0.30A 4ef3A-1zpuA:
30.1		 4ef3A-1zpuA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 418
HIS A 483
HIS A  81
HIS A 128
 CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
CU1  A1004 (-3.3A)
CU1  A1002 (-3.3A)
 0.68A 4ef3A-1zpuA:
30.1		 4ef3A-1zpuA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		4 HIS A 391
HIS A 393
HIS A 681
HIS A 659
 ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.2A)
CF5  A 841 (-4.2A)
ZN  A 840 ( 3.1A)
 1.13A 4ef3A-2a3lA:
undetectable		 4ef3A-2a3lA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		4 HIS A 659
HIS A 681
HIS A 393
HIS A 391
 ZN  A 840 ( 3.1A)
CF5  A 841 (-4.2A)
ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.2A)
 1.04A 4ef3A-2a3lA:
undetectable		 4ef3A-2a3lA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amx ADENOSINE DEAMINASE

(Plasmodium
yoelii) 		PF00962
(A_deaminase) 		4 HIS A  55
HIS A  57
HIS A 266
HIS A 239
 CO  A1000 (-3.3A)
CO  A1000 (-3.2A)
None
CO  A1000 (-3.4A)
 1.02A 4ef3A-2amxA:
undetectable		 4ef3A-2amxA:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 103
HIS A 141
HIS A 446
HIS A 501
 C2O  A 602 (-3.0A)
C2O  A 602 (-3.2A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.4A)
 0.11A 4ef3A-2fqdA:
70.4		 4ef3A-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 448
HIS A 499
HIS A 101
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.5A)
 0.67A 4ef3A-2fqdA:
70.4		 4ef3A-2fqdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
HIS A 109
HIS A 398
HIS A 454
 CU  A 603 ( 3.1A)
CU  A 603 (-3.4A)
CU  A 604 (-3.1A)
CU  A 603 (-3.3A)
 0.31A 4ef3A-2hzhA:
32.2		 4ef3A-2hzhA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 400
HIS A 452
HIS A  64
HIS A 111
 CU  A 602 ( 3.2A)
CU  A 602 (-3.1A)
CU  A 604 ( 3.1A)
CU  A 602 (-3.2A)
 0.72A 4ef3A-2hzhA:
32.2		 4ef3A-2hzhA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		4 HIS A  79
HIS A  81
HIS A 273
HIS A 234
 ZN  A 500 ( 3.3A)
ZN  A 500 ( 3.3A)
GUN  A 600 (-3.9A)
GUN  A 600 ( 2.8A)
 0.99A 4ef3A-2oodA:
undetectable		 4ef3A-2oodA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		4 HIS A  60
HIS A  62
HIS A 249
HIS A 217
 ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
None
ZN  A 501 (-3.5A)
 0.98A 4ef3A-2qt3A:
undetectable		 4ef3A-2qt3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
HIS A 109
HIS A 397
HIS A 453
 CU  A 502 ( 3.1A)
CU  A 502 (-3.2A)
CU  A 500 (-3.1A)
CU  A 502 (-3.3A)
 0.30A 4ef3A-2qt6A:
32.3		 4ef3A-2qt6A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 399
HIS A 451
HIS A  64
HIS A 111
 CU  A 501 ( 3.2A)
CU  A 501 (-3.2A)
CU  A 500 (-3.1A)
CU  A 501 ( 3.2A)
 0.68A 4ef3A-2qt6A:
32.3		 4ef3A-2qt6A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 453
HIS A 397
HIS A 109
HIS A  66
 CU  A 502 (-3.3A)
CU  A 500 (-3.1A)
CU  A 502 (-3.2A)
CU  A 502 ( 3.1A)
 1.18A 4ef3A-2qt6A:
32.3		 4ef3A-2qt6A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
HIS A 109
HIS A 398
HIS A 452
 CU  A 503 (-3.1A)
CU  A 503 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 503 ( 3.3A)
 0.30A 4ef3A-2xybA:
32.2		 4ef3A-2xybA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 400
HIS A 450
HIS A  64
HIS A 111
 CU  A 502 (-3.2A)
CU  A 502 ( 3.3A)
CU  A 504 ( 3.1A)
CU  A 502 (-3.2A)
 0.72A 4ef3A-2xybA:
32.2		 4ef3A-2xybA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  96
HIS A 134
HIS A 401
HIS A 458
 CU  A 702 ( 3.2A)
CU  A 702 (-3.1A)
CU  A 703 (-3.4A)
CU  A 702 (-3.5A)
 0.32A 4ef3A-3abgA:
42.2		 4ef3A-3abgA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 403
HIS A 456
HIS A  94
HIS A 136
 CU  A 701 ( 3.1A)
CU  A 701 (-3.3A)
CU  A 703 (-3.0A)
CU  A 701 (-3.2A)
 0.81A 4ef3A-3abgA:
42.2		 4ef3A-3abgA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  94
HIS A 132
HIS A 394
HIS A 461
 C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.5A)
 0.22A 4ef3A-3aw5A:
45.2		 4ef3A-3aw5A:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 396
HIS A 459
HIS A  92
HIS A 134
 C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
 0.66A 4ef3A-3aw5A:
45.2		 4ef3A-3aw5A:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  95
HIS A 138
HIS A 434
HIS A 504
 CU  A 603 ( 3.2A)
CU  A 603 ( 3.3A)
CU  A 604 (-3.2A)
CU  A 603 ( 3.3A)
 0.36A 4ef3A-3dkhA:
28.6		 4ef3A-3dkhA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 436
HIS A 502
HIS A  93
HIS A 140
 CU  A 602 (-3.2A)
CU  A 602 ( 3.2A)
CU  A 604 (-3.1A)
CU  A 602 ( 3.3A)
 0.67A 4ef3A-3dkhA:
28.6		 4ef3A-3dkhA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0l GUANINE DEAMINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 HIS A  82
HIS A  84
HIS A 277
HIS A 238
 ZN  A1452 (-3.3A)
ZN  A1452 (-3.1A)
None
ZN  A1452 (-3.2A)
 1.22A 4ef3A-3e0lA:
undetectable		 4ef3A-3e0lA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewd ADENOSINE DEAMINASE

(Plasmodium
vivax) 		PF00962
(A_deaminase) 		4 HIS A  42
HIS A  44
HIS A 252
HIS A 225
 ZN  A 371 (-3.3A)
MCF  A 372 ( 3.3A)
MCF  A 372 (-4.1A)
ZN  A 371 ( 3.4A)
 1.03A 4ef3A-3ewdA:
undetectable		 4ef3A-3ewdA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		4 HIS A  61
HIS A  63
HIS A 246
HIS A 214
 FE  A 502 (-3.1A)
FE  A 502 (-3.1A)
FE  A 502 ( 4.8A)
FE  A 502 (-3.6A)
 0.98A 4ef3A-3g77A:
undetectable		 4ef3A-3g77A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 163
HIS A 201
HIS A 527
HIS A 604
 C2O  A1002 (-3.3A)
C2O  A1002 (-3.7A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.9A)
 0.30A 4ef3A-3gyrA:
37.2		 4ef3A-3gyrA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 529
HIS A 602
HIS A 161
HIS A 203
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.72A 4ef3A-3gyrA:
37.2		 4ef3A-3gyrA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ht1 REMF PROTEIN

(Streptomyces
resistomycificus) 		PF07883
(Cupin_2) 		4 HIS A  95
HIS A  59
HIS A  53
HIS A  55
 NI  A 151 (-3.3A)
NI  A 151 (-3.3A)
NI  A 151 (-3.3A)
NI  A 151 (-3.3A)
 1.12A 4ef3A-3ht1A:
undetectable		 4ef3A-3ht1A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
HIS A 109
HIS A 403
HIS A 457
 CU  A 604 ( 2.9A)
CU  A 604 (-3.2A)
CU  A 602 (-3.0A)
CU  A 604 (-3.1A)
 0.34A 4ef3A-3kw7A:
31.9		 4ef3A-3kw7A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 405
HIS A 455
HIS A  64
HIS A 111
 CU  A 603 ( 3.0A)
CU  A 603 (-3.1A)
CU  A 602 (-3.1A)
CU  A 603 (-3.2A)
 0.70A 4ef3A-3kw7A:
31.9		 4ef3A-3kw7A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgg ADENOSINE DEAMINASE
CECR1

(Homo sapiens) 		PF00962
(A_deaminase)
PF08451
(A_deaminase_N) 		4 HIS A  86
HIS A  88
HIS A 358
HIS A 330
 ZN  A 512 (-3.4A)
CFE  A 513 ( 3.3A)
CFE  A 513 ( 4.3A)
ZN  A 512 ( 3.5A)
 0.95A 4ef3A-3lggA:
undetectable		 4ef3A-3lggA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pao ADENOSINE DEAMINASE

(Pseudomonas
aeruginosa) 		PF00962
(A_deaminase) 		4 HIS A  16
HIS A  18
HIS A 220
HIS A 196
 ZN  A 327 (-3.4A)
ADE  A 328 ( 3.0A)
ADE  A 328 ( 4.2A)
ZN  A 327 ( 3.5A)
 0.94A 4ef3A-3paoA:
undetectable		 4ef3A-3paoA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  96
HIS A 139
HIS A 435
HIS A 505
 CU  A 603 ( 3.1A)
CU  A 603 ( 3.1A)
CU  A 604 ( 3.3A)
CU  A 603 ( 3.3A)
 0.27A 4ef3A-3ppsA:
28.4		 4ef3A-3ppsA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 437
HIS A 503
HIS A  94
HIS A 141
 CU  A 602 (-3.3A)
CU  A 602 ( 3.3A)
CU  A 604 ( 3.1A)
CU  A 602 ( 3.3A)
 0.62A 4ef3A-3ppsA:
28.4		 4ef3A-3ppsA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 505
HIS A 435
HIS A 139
HIS A  96
 CU  A 603 ( 3.3A)
CU  A 604 ( 3.3A)
CU  A 603 ( 3.1A)
CU  A 603 ( 3.1A)
 1.16A 4ef3A-3ppsA:
28.4		 4ef3A-3ppsA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
HIS A 109
HIS A 398
HIS A 454
 CU  A1501 ( 3.0A)
CU  A1501 (-3.2A)
CU  A1502 ( 2.9A)
CU  A1501 (-3.3A)
 0.35A 4ef3A-3pxlA:
32.3		 4ef3A-3pxlA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 400
HIS A 452
HIS A  64
HIS A 111
 CU  A1500 ( 3.2A)
CU  A1500 (-3.1A)
CU  A1502 ( 3.0A)
CU  A1500 (-3.2A)
 0.66A 4ef3A-3pxlA:
32.3		 4ef3A-3pxlA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rys ADENOSINE DEAMINASE
1

(Paenarthrobacter
aurescens) 		PF00962
(A_deaminase) 		4 HIS A  19
HIS A  21
HIS A 223
HIS A 199
 ZN  A 344 (-3.5A)
ADE  A 345 ( 3.2A)
ADE  A 345 ( 4.2A)
ZN  A 344 ( 3.4A)
 0.93A 4ef3A-3rysA:
undetectable		 4ef3A-3rysA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  67
HIS A 110
HIS A 400
HIS A 454
 CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
CU  A 504 ( 3.1A)
OXY  A 511 ( 3.2A)
 0.27A 4ef3A-3t6wA:
33.1		 4ef3A-3t6wA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 402
HIS A 452
HIS A  65
HIS A 112
 CU  A 503 ( 3.2A)
CU  A 503 ( 3.3A)
CU  A 504 (-3.1A)
CU  A 503 (-3.4A)
 0.64A 4ef3A-3t6wA:
33.1		 4ef3A-3t6wA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		4 HIS A  61
HIS A  63
HIS A 257
HIS A 206
 FE  A 429 (-3.2A)
FE  A 429 (-3.2A)
None
FE  A 429 (-3.3A)
 1.17A 4ef3A-3v7pA:
undetectable		 4ef3A-3v7pA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  89
HIS A 131
HIS A 429
HIS A 490
 CU  A 603 (-2.9A)
CU  A 603 (-3.2A)
CU  A 602 (-3.6A)
CU  A 603 (-3.5A)
 0.31A 4ef3A-3v9eA:
29.7		 4ef3A-3v9eA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 133
HIS A  87
HIS A 488
HIS A 431
 CU  A 602 (-3.3A)
CU  A 602 ( 4.7A)
CU  A 602 (-3.1A)
CU  A 602 (-3.1A)
 1.17A 4ef3A-3v9eA:
29.7		 4ef3A-3v9eA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 431
HIS A 488
HIS A  87
HIS A 133
 CU  A 602 (-3.1A)
CU  A 602 (-3.1A)
CU  A 602 ( 4.7A)
CU  A 602 (-3.3A)
 0.73A 4ef3A-3v9eA:
29.7		 4ef3A-3v9eA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  87
HIS A 130
HIS A 420
HIS A 476
 CU  A 615 ( 3.1A)
CU  A 615 (-3.2A)
CU  A 614 (-3.1A)
CU  A 615 (-3.2A)
 0.30A 4ef3A-3x1bA:
32.3		 4ef3A-3x1bA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 422
HIS A 474
HIS A  85
HIS A 132
 CU  A 616 ( 3.2A)
CU  A 616 (-3.2A)
CU  A 614 (-3.1A)
CU  A 616 (-3.2A)
 0.67A 4ef3A-3x1bA:
32.3		 4ef3A-3x1bA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 141
HIS A 180
HIS A 442
HIS A 496
 CU  A 602 (-3.0A)
CU  A 602 ( 3.1A)
CU  A 604 ( 3.0A)
CU  A 602 ( 3.3A)
 0.27A 4ef3A-3zx1A:
44.5		 4ef3A-3zx1A:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 444
HIS A 494
HIS A 139
HIS A 182
 CU  A 603 (-3.1A)
CU  A 603 ( 3.1A)
CU  A 604 ( 3.0A)
CU  A 603 ( 2.8A)
 0.70A 4ef3A-3zx1A:
44.5		 4ef3A-3zx1A:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 107
HIS A 153
HIS A 422
HIS A 493
 CU  A 602 (-3.1A)
CU  A 602 ( 3.2A)
CU  A 604 ( 3.1A)
CU  A 602 ( 3.2A)
 0.24A 4ef3A-4akoA:
44.1		 4ef3A-4akoA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 424
HIS A 491
HIS A 105
HIS A 155
 CU  A 603 (-3.2A)
CU  A 603 ( 3.1A)
CU  A 604 ( 3.1A)
CU  A 603 ( 3.2A)
 0.62A 4ef3A-4akoA:
44.1		 4ef3A-4akoA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 602
HIS A 606
HIS A 491
HIS A 633
 CUO  A9002 (-3.4A)
CUO  A9002 (-3.3A)
CUO  A9002 (-3.4A)
CUO  A9002 (-3.3A)
 1.18A 4ef3A-4bedA:
undetectable		 4ef3A-4bedA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A1015
HIS A1019
HIS A 905
HIS A1046
 CUO  A9003 (-3.1A)
CUO  A9003 (-3.4A)
CUO  A9003 (-3.5A)
CUO  A9003 (-3.2A)
 1.17A 4ef3A-4bedA:
undetectable		 4ef3A-4bedA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxw ADENOSINE DEAMINASE

(Burkholderia
ambifaria) 		PF00962
(A_deaminase) 		4 HIS A  34
HIS A  36
HIS A 240
HIS A 215
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
None
ZN  A 401 (-3.4A)
 0.96A 4ef3A-4gxwA:
undetectable		 4ef3A-4gxwA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifr 2-AMINO-3-CARBOXYMUC
ONATE 6-SEMIALDEHYDE
DECARBOXYLASE

(Pseudomonas
fluorescens) 		PF04909
(Amidohydro_2) 		4 HIS A   9
HIS A  11
HIS A 228
HIS A 177
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.4A)
ZN  A 401 ( 4.7A)
ZN  A 401 (-3.6A)
 1.24A 4ef3A-4ifrA:
undetectable		 4ef3A-4ifrA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
HIS A 109
HIS A 397
HIS A 451
 CU  A 502 ( 3.1A)
CU  A 502 (-3.2A)
CU  A 504 (-2.7A)
CU  A 502 (-3.3A)
 0.32A 4ef3A-4jhvA:
31.9		 4ef3A-4jhvA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 399
HIS A 449
HIS A  64
HIS A 111
 CU  A 501 ( 3.2A)
CU  A 501 (-3.1A)
CU  A 504 ( 2.8A)
CU  A 501 (-3.2A)
 0.65A 4ef3A-4jhvA:
31.9		 4ef3A-4jhvA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		4 HIS A  56
HIS A  58
HIS A 241
HIS A 209
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.5A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 3.4A)
 0.97A 4ef3A-4r85A:
undetectable		 4ef3A-4r85A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		4 HIS A  66
HIS A  68
HIS A 276
HIS A 243
 FE  A 481 (-3.9A)
FE  A 481 (-3.9A)
FE  A 481 (-3.9A)
FE  A 481 (-4.1A)
 1.09A 4ef3A-4v1yA:
undetectable		 4ef3A-4v1yA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		4 HIS A 157
HIS A 153
HIS A 298
HIS A 297
 ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
ZN  A 402 (-3.4A)
ZN  A 401 (-3.2A)
 0.96A 4ef3A-4ymkA:
undetectable		 4ef3A-4ymkA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		4 HIS A 298
HIS A 265
HIS A 157
HIS A 156
 ZN  A 402 (-3.4A)
ZN  A 402 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 402 (-3.4A)
 1.18A 4ef3A-4ymkA:
undetectable		 4ef3A-4ymkA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		4 HIS A 298
HIS A 294
HIS A 157
HIS A 156
 ZN  A 402 (-3.4A)
ZN  A 402 (-3.1A)
ZN  A 401 (-3.3A)
ZN  A 402 (-3.4A)
 1.03A 4ef3A-4ymkA:
undetectable		 4ef3A-4ymkA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 272
HIS A 268
HIS A 349
HIS A 348
 ZN  A 402 (-3.4A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
 1.05A 4ef3A-4zr0A:
undetectable		 4ef3A-4zr0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 349
HIS A 345
HIS A 272
HIS A 271
 ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
ZN  A 402 (-3.4A)
ZN  A 401 (-3.2A)
 1.09A 4ef3A-4zr0A:
undetectable		 4ef3A-4zr0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 272
HIS A 173
HIS A 268
HIS A 249
 ZN  A 402 (-3.5A)
None
ZN  A 402 (-3.3A)
ZN  A 402 (-3.2A)
 1.17A 4ef3A-4zr1A:
undetectable		 4ef3A-4zr1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 272
HIS A 268
HIS A 349
HIS A 348
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
 1.10A 4ef3A-4zr1A:
undetectable		 4ef3A-4zr1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 349
HIS A 345
HIS A 272
HIS A 271
 ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.5A)
ZN  A 401 ( 3.4A)
 1.10A 4ef3A-4zr1A:
undetectable		 4ef3A-4zr1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 HIS A 161
HIS A 157
HIS A 302
HIS A 301
 ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.4A)
 1.11A 4ef3A-4zyoA:
undetectable		 4ef3A-4zyoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 HIS A 301
HIS A 161
HIS A 120
HIS A 125
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.3A)
ZN  A 401 (-3.2A)
 1.12A 4ef3A-4zyoA:
undetectable		 4ef3A-4zyoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 HIS A 302
HIS A 269
HIS A 161
HIS A 160
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 402 (-3.2A)
 1.14A 4ef3A-4zyoA:
undetectable		 4ef3A-4zyoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 HIS A 302
HIS A 298
HIS A 161
HIS A 160
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.3A)
ZN  A 402 (-3.2A)
 1.02A 4ef3A-4zyoA:
undetectable		 4ef3A-4zyoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  66
HIS A 109
HIS A 398
HIS A 452
 CU  A 508 ( 3.1A)
CU  A 508 (-3.3A)
CU  A 509 ( 3.1A)
CU  A 508 (-3.2A)
 0.24A 4ef3A-5ehfA:
33.1		 4ef3A-5ehfA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A  64
HIS A 450
HIS A 400
 CU  A 507 ( 3.3A)
CU  A 509 (-3.2A)
CU  A 507 (-3.2A)
CU  A 507 ( 3.1A)
 1.24A 4ef3A-5ehfA:
33.1		 4ef3A-5ehfA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 400
HIS A 450
HIS A  64
HIS A 111
 CU  A 507 ( 3.1A)
CU  A 507 (-3.2A)
CU  A 509 (-3.2A)
CU  A 507 ( 3.3A)
 0.71A 4ef3A-5ehfA:
33.1		 4ef3A-5ehfA:
23.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  97
HIS A 135
HIS A 396
HIS A 446
 CU  A1465 (-3.1A)
CU  A1465 (-3.2A)
CU  A1463 ( 4.8A)
CU  A1465 (-3.3A)
 0.22A 4ef3A-5g3fA:
48.0		 4ef3A-5g3fA:
33.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 396
HIS A 444
HIS A  97
HIS A  95
 CU  A1463 ( 4.8A)
CU  A1463 (-3.0A)
CU  A1465 (-3.1A)
CU  A1463 (-4.1A)
 0.84A 4ef3A-5g3fA:
48.0		 4ef3A-5g3fA:
33.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 444
HIS A  95
HIS A 137
 CU  A1463 (-2.9A)
CU  A1463 (-3.0A)
CU  A1463 (-4.1A)
CU  A1463 (-3.3A)
 0.75A 4ef3A-5g3fA:
48.0		 4ef3A-5g3fA:
33.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 110
HIS A 152
HIS A 451
HIS A 517
 CU  A 601 (-2.9A)
CU  A 601 ( 3.2A)
CU  A 603 (-2.8A)
CU  A 601 ( 3.5A)
 0.20A 4ef3A-5lm8A:
29.5		 4ef3A-5lm8A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 453
HIS A 515
HIS A 108
HIS A 154
 CU  A 602 (-3.1A)
CU  A 602 ( 3.2A)
CU  A 603 ( 3.1A)
CU  A 602 ( 3.4A)
 0.70A 4ef3A-5lm8A:
29.5		 4ef3A-5lm8A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  67
HIS A 110
HIS A 400
HIS A 454
 CU  A 502 ( 2.9A)
CU  A 502 (-3.1A)
CU  A 503 ( 3.1A)
CU  A 502 ( 3.2A)
 0.23A 4ef3A-5mewA:
32.6		 4ef3A-5mewA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 402
HIS A 452
HIS A  65
HIS A 112
 CU  A 501 (-3.2A)
CU  A 501 ( 3.0A)
CU  A 503 (-3.1A)
CU  A 501 (-3.1A)
 0.61A 4ef3A-5mewA:
32.6		 4ef3A-5mewA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 HIS A 103
HIS A 160
HIS A 972
HIS A1016
 CU  A1104 ( 3.5A)
CU  A1104 (-3.6A)
CU  A1105 (-3.3A)
CU  A1104 (-3.1A)
 0.74A 4ef3A-5n4lA:
25.4		 4ef3A-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 HIS A 974
HIS A1014
HIS A 101
HIS A 162
 CU  A1101 ( 3.2A)
CU  A1101 (-3.2A)
CU  A1105 (-3.1A)
CU  A1101 (-3.3A)
 0.72A 4ef3A-5n4lA:
25.4		 4ef3A-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A  91
HIS A 131
HIS A 439
HIS A  93
 EDO  A 602 ( 4.5A)
None
EDO  A 602 (-3.8A)
None
 1.21A 4ef3A-6evgA:
53.2		 4ef3A-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A  93
HIS A 131
HIS A 437
HIS A 491
 None
 0.32A 4ef3A-6evgA:
53.2		 4ef3A-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A 437
HIS A 489
HIS A  93
HIS A 439
 None
None
None
EDO  A 602 (-3.8A)
 0.89A 4ef3A-6evgA:
53.2		 4ef3A-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A 439
HIS A 489
HIS A  91
HIS A 133
 EDO  A 602 (-3.8A)
None
EDO  A 602 ( 4.5A)
EDO  A 602 (-4.1A)
 0.77A 4ef3A-6evgA:
53.2		 4ef3A-6evgA:
undetectable