SIMILAR PATTERNS OF AMINO ACIDS FOR 4EBK_B_TOYB302_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a62 CADHERIN-8

(Mus musculus) 		PF00028
(Cadherin) 		5 ASP A 134
GLU A  67
GLU A  12
ASP A  64
GLU A  11
 CA  A 324 ( 3.1A)
None
CA  A 325 (-3.3A)
CA  A 325 (-3.0A)
CA  A 325 ( 2.5A)
 1.50A 4ebkA-2a62A:
0.0
4ebkB-2a62A:
0.0		 4ebkA-2a62A:
21.99
4ebkB-2a62A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7v AECTYLCITRULLINE
DEACETYLASE

(Xanthomonas
campestris) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ASP A 103
ALA A 154
GLU A 130
ASP A  74
GLU A 131
 CO  A5367 (-2.2A)
None
CO  A5367 (-3.8A)
None
CO  A5367 ( 4.0A)
 1.39A 4ebkA-2f7vA:
0.0
4ebkB-2f7vA:
0.0		 4ebkA-2f7vA:
24.67
4ebkB-2f7vA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 GLU A 572
TYR A 613
ALA A 616
GLU A 382
ASP A 283
 None
None
None
None
NBG  A   1 ( 4.5A)
 1.46A 4ebkA-3cemA:
0.4
4ebkB-3cemA:
0.4		 4ebkA-3cemA:
15.98
4ebkB-3cemA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913) 		PF00082
(Peptidase_S8) 		5 ASP A 231
GLU A  17
ALA A  24
GLU A  32
ASP A  29
 None
None
None
CA  A 402 ( 4.2A)
CA  A 403 ( 2.2A)
 1.40A 4ebkA-3vv3A:
0.5
4ebkB-3vv3A:
0.5		 4ebkA-3vv3A:
21.93
4ebkB-3vv3A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvi SLOR

(Streptococcus
mutans) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C)
PF04023
(FeoA) 		5 ASP A   7
TYR A  73
ALA A  69
GLU A 102
GLU A  99
 ZN  A 301 (-2.5A)
None
None
ZN  A 301 (-3.0A)
ZN  A 301 (-2.2A)
 1.49A 4ebkA-5cviA:
0.0
4ebkB-5cviA:
0.0		 4ebkA-5cviA:
20.64
4ebkB-5cviA:
20.64