SIMILAR PATTERNS OF AMINO ACIDS FOR 4EAT_B_BEZB1000_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1al8 | GLYCOLATE OXIDASE (Spinaciaoleracea) |
PF01070(FMN_dh) | 5 | ALA A 302ALA A 276GLY A 278ILE A 280ILE A 249 | None | 1.07A | 4eatB-1al8A:undetectable | 4eatB-1al8A:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ejb | LUMAZINE SYNTHASE (Saccharomycescerevisiae) |
PF00885(DMRL_synthase) | 5 | ALA A 156ALA A 38GLY A 149ILE A 87ILE A 21 | None | 1.14A | 4eatB-1ejbA:3.1 | 4eatB-1ejbA:15.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g0u | PROTEASOME COMPONENTPUP2 (Saccharomycescerevisiae) |
PF00227(Proteasome)PF10584(Proteasome_A_N) | 5 | ALA D 41TYR D 146GLY D 145GLY D 140ILE D 215 | None | 1.05A | 4eatB-1g0uD:undetectable | 4eatB-1g0uD:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ghs | 1,3-BETA-GLUCANASE (Hordeum vulgare) |
PF00332(Glyco_hydro_17) | 5 | ALA A 247TYR A 250GLY A 253ILE A 255ILE A 273 | None | 1.08A | 4eatB-1ghsA:undetectable | 4eatB-1ghsA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h3e | TYROSYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00579(tRNA-synt_1b) | 5 | ALA A 112TYR A 108ALA A 44ILE A 75ILE A 76 | NoneNoneATP A1433 (-3.8A)TYE A1434 ( 3.9A)None | 1.15A | 4eatB-1h3eA:undetectable | 4eatB-1h3eA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iwp | GLYCEROL DEHYDRATASEALPHA SUBUNIT (Klebsiellapneumoniae) |
PF02286(Dehydratase_LU) | 5 | ALA A 162ALA A 416GLY A 190GLY A 194ILE A 412 | None | 1.13A | 4eatB-1iwpA:undetectable | 4eatB-1iwpA:24.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jbi | COCHLIN (Homo sapiens) |
PF03815(LCCL) | 5 | ALA A 42TYR A 41ALA A 50GLY A 49ILE A 47 | None | 1.06A | 4eatB-1jbiA:undetectable | 4eatB-1jbiA:12.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kz1 | 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE (Schizosaccharomycespombe) |
PF00885(DMRL_synthase) | 5 | ALA A 150ALA A 39GLY A 143ILE A 84ILE A 22 | None | 1.14A | 4eatB-1kz1A:2.0 | 4eatB-1kz1A:15.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x53 | ACTIVATOR OF 90 KDAHEAT SHOCK PROTEINATPASE HOMOLOG 1 (Homo sapiens) |
PF08327(AHSA1) | 5 | ALA A 89GLY A 110ILE A 13GLY A 108ILE A 91 | None | 1.07A | 4eatB-1x53A:undetectable | 4eatB-1x53A:13.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xat | XENOBIOTICACETYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00132(Hexapep) | 5 | ALA A 141ALA A 69GLY A 68GLY A 120ILE A 119 | None | 1.12A | 4eatB-1xatA:undetectable | 4eatB-1xatA:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yy5 | FMS1 PROTEIN (Saccharomycescerevisiae) |
PF01593(Amino_oxidase) | 5 | ALA A 23ALA A 492GLY A 478GLY A 17ILE A 18 | NoneFAD A 803 (-3.3A)FAD A 803 (-2.9A)FAD A 803 (-3.6A)FAD A 803 (-4.7A) | 1.12A | 4eatB-1yy5A:undetectable | 4eatB-1yy5A:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cfc | 2-(R)-HYDROXYPROPYL-COM DEHYDROGENASE (Xanthobacterautotrophicus) |
PF13561(adh_short_C2) | 5 | ALA A 249TYR A 247GLY A 186GLY A 245ILE A 210 | NoneNoneKPC A1252 (-4.7A)NoneNone | 1.05A | 4eatB-2cfcA:undetectable | 4eatB-2cfcA:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2chg | REPLICATION FACTOR CSMALL SUBUNIT (Archaeoglobusfulgidus) |
PF00004(AAA) | 5 | ALA A 207ALA A 188GLY A 185ILE A 190ILE A 192 | None | 1.15A | 4eatB-2chgA:undetectable | 4eatB-2chgA:16.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d57 | AQUAPORIN-4 (Rattusnorvegicus) |
PF00230(MIP) | 5 | ALA A 215ALA A 130ILE A 128GLY A 125ILE A 127 | None | 0.98A | 4eatB-2d57A:undetectable | 4eatB-2d57A:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dst | HYPOTHETICAL PROTEINTTHA1544 (Thermusthermophilus) |
no annotation | 5 | ALA A 67ALA A 92GLY A 90GLY A 94HIS A 96 | None | 1.15A | 4eatB-2dstA:3.4 | 4eatB-2dstA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2euh | NADP DEPENDENT NONPHOSPHORYLATINGGLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Streptococcusmutans) |
PF00171(Aldedh) | 5 | ALA A 452GLY A 230ILE A 234GLY A 235ILE A 238 | NoneNAP A 476 (-3.1A)NAP A 476 (-3.8A)NoneNone | 1.12A | 4eatB-2euhA:2.6 | 4eatB-2euhA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ew7 | PEPTIDE DEFORMYLASE (Helicobacterpylori) |
PF01327(Pep_deformylase) | 5 | ALA A 48ALA A 135ILE A 45GLY A 46ILE A 61 | None | 1.13A | 4eatB-2ew7A:undetectable | 4eatB-2ew7A:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f4n | HYPOTHETICAL PROTEINMJ1651 (Methanocaldococcusjannaschii) |
PF01887(SAM_adeno_trans) | 5 | ALA A 116ALA A 64ILE A 60GLY A 110ILE A 168 | None | 0.87A | 4eatB-2f4nA:undetectable | 4eatB-2f4nA:17.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g40 | CONSERVEDHYPOTHETICAL PROTEIN (Deinococcusradiodurans) |
PF02589(LUD_dom) | 5 | ALA A 64ALA A 70GLY A 69ILE A 71ILE A 209 | None | 0.98A | 4eatB-2g40A:undetectable | 4eatB-2g40A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jax | HYPOTHETICAL PROTEINTB31.7 (Mycobacteriumtuberculosis) |
PF00582(Usp) | 5 | ALA A 27ALA A 20GLY A 117GLY A 13ILE A 14 | NoneATP A1296 (-2.6A)ATP A1296 (-2.5A)ATP A1296 (-3.3A)None | 1.11A | 4eatB-2jaxA:undetectable | 4eatB-2jaxA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jqj | DNA DAMAGE RESPONSEPROTEIN KINASE DUN1 (Saccharomycescerevisiae) |
PF00498(FHA) | 5 | ALA A 78ILE A 67GLY A 59HIS A 77ILE A 73 | None | 1.12A | 4eatB-2jqjA:undetectable | 4eatB-2jqjA:12.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mpk | CHITIN SYNTHASE 1 (Saprolegniamonoica) |
PF04212(MIT) | 5 | ALA A 26TYR A 23ALA A 17ILE A 15ILE A 71 | None | 1.09A | 4eatB-2mpkA:undetectable | 4eatB-2mpkA:8.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o1x | 1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE (Deinococcusradiodurans) |
PF02779(Transket_pyr)PF02780(Transketolase_C)PF13292(DXP_synthase_N) | 5 | ALA A 516ALA A 607GLY A 608GLY A 589ILE A 590 | None | 0.97A | 4eatB-2o1xA:undetectable | 4eatB-2o1xA:24.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p9w | MAL S 1 ALLERGENICPROTEIN (Malasseziasympodialis) |
no annotation | 6 | ALA A 177TYR A 209GLY A 225ILE A 260GLY A 211ILE A 212 | None | 1.17A | 4eatB-2p9wA:undetectable | 4eatB-2p9wA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2po4 | VIRION RNAPOLYMERASE (Escherichiavirus N4) |
no annotation | 5 | ALA A 819ALA A 915GLY A 916GLY A 919ILE A 882 | None | 0.94A | 4eatB-2po4A:undetectable | 4eatB-2po4A:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q3o | 12-OXOPHYTODIENOATEREDUCTASE 3 (Arabidopsisthaliana) |
PF00724(Oxidored_FMN) | 5 | ALA A 276GLY A 231ILE A 176GLY A 182ILE A 183 | None | 1.10A | 4eatB-2q3oA:undetectable | 4eatB-2q3oA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q9r | PROTEIN OF UNKNOWNFUNCTION (Shewanellabaltica) |
PF04222(DUF416) | 5 | ALA A 100ALA A 107GLY A 106ILE A 108ILE A 116 | None | 1.10A | 4eatB-2q9rA:undetectable | 4eatB-2q9rA:16.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2v7b | BENZOATE-COENZYME ALIGASE (Paraburkholderiaxenovorans) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 7 | ALA A 237TYR A 238ALA A 308GLY A 309GLY A 333HIS A 339LYS A 520 | BEZ A1529 ( 3.7A)BEZ A1529 (-4.3A)BEZ A1529 (-3.6A)BEZ A1529 (-3.5A)BEZ A1529 (-3.6A)BEZ A1529 (-3.8A)BEZ A1529 (-2.9A) | 1.18A | 4eatB-2v7bA:62.1 | 4eatB-2v7bA:60.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2v7b | BENZOATE-COENZYME ALIGASE (Paraburkholderiaxenovorans) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 8 | ALA A 237TYR A 238ALA A 308GLY A 309ILE A 332GLY A 333HIS A 339ILE A 340 | BEZ A1529 ( 3.7A)BEZ A1529 (-4.3A)BEZ A1529 (-3.6A)BEZ A1529 (-3.5A)NoneBEZ A1529 (-3.6A)BEZ A1529 (-3.8A)BEZ A1529 ( 4.9A) | 0.27A | 4eatB-2v7bA:62.1 | 4eatB-2v7bA:60.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ywx | PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASECATALYTIC SUBUNIT (Methanocaldococcusjannaschii) |
PF00731(AIRC) | 5 | ALA A 119ALA A 18GLY A 112ILE A 58ILE A 4 | None | 1.08A | 4eatB-2ywxA:4.1 | 4eatB-2ywxA:14.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zts | PUTATIVEUNCHARACTERIZEDPROTEIN PH0186 (Pyrococcushorikoshii) |
PF06745(ATPase) | 5 | ALA A 55GLY A 54ILE A 51GLY A 62ILE A 94 | None | 1.09A | 4eatB-2ztsA:2.3 | 4eatB-2ztsA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b3d | PUTATIVE MORPHINEDEHYDROGENASE (Bacillussubtilis) |
PF00248(Aldo_ket_red) | 5 | ALA A 71GLY A 72ILE A 68GLY A 67ILE A 41 | None | 1.14A | 4eatB-3b3dA:undetectable | 4eatB-3b3dA:18.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3das | PUTATIVEOXIDOREDUCTASE (Streptomycescoelicolor) |
PF07995(GSDH) | 5 | ALA A 217GLY A 206GLY A 156HIS A 201ILE A 176 | None | 1.05A | 4eatB-3dasA:undetectable | 4eatB-3dasA:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddd | PUTATIVEACETYLTRANSFERASE (Pyrococcushorikoshii) |
PF00583(Acetyltransf_1) | 5 | ALA A 176ALA A 212ILE A 208GLY A 187ILE A 194 | None | 1.08A | 4eatB-3dddA:undetectable | 4eatB-3dddA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fah | ALDEHYDEOXIDOREDUCTASE (Desulfovibriogigas) |
PF00111(Fer2)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2) | 5 | ALA A 537ALA A 508GLY A 507ILE A 619GLY A 620 | None | 1.12A | 4eatB-3fahA:2.4 | 4eatB-3fahA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fk5 | 3-OXOACYL-SYNTHASEIII (Xanthomonasoryzae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | ALA A 212ALA A 241ILE A 238GLY A 237ILE A 325 | None | 1.00A | 4eatB-3fk5A:undetectable | 4eatB-3fk5A:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7g | UPF0311 PROTEINCA_C3321 (Clostridiumacetobutylicum) |
PF11578(DUF3237) | 5 | ALA A 78ALA A 75ILE A 60GLY A 59ILE A 41 | None | 0.91A | 4eatB-3g7gA:undetectable | 4eatB-3g7gA:15.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gvx | GLYCERATEDEHYDROGENASERELATED PROTEIN (Thermoplasmaacidophilum) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | ALA A 138ALA A 180GLY A 129GLY A 132ILE A 133 | None | 1.15A | 4eatB-3gvxA:6.0 | 4eatB-3gvxA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h0l | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT A (Aquifexaeolicus) |
PF01425(Amidase) | 5 | ALA A 50ALA A 109GLY A 108ILE A 67ILE A 69 | None | 1.05A | 4eatB-3h0lA:undetectable | 4eatB-3h0lA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hee | RIBOSE-5-PHOSPHATEISOMERASE (Ruminiclostridiumthermocellum) |
PF02502(LacAB_rpiB) | 5 | ALA A 52GLY A 6ILE A 62GLY A 61ILE A 103 | None | 0.77A | 4eatB-3heeA:undetectable | 4eatB-3heeA:14.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i6t | MUCONATECYCLOISOMERASE (Jannaschia sp.CCS1) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 9GLY A 10ILE A 8GLY A 81ILE A 7 | None | 1.09A | 4eatB-3i6tA:undetectable | 4eatB-3i6tA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ifq | PLAKOGLOBIN (Homo sapiens) |
PF00514(Arm) | 5 | ALA A 566GLY A 565ILE A 502GLY A 503ILE A 505 | None | 0.95A | 4eatB-3ifqA:undetectable | 4eatB-3ifqA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3in1 | UNCHARACTERIZEDSUGAR KINASE YDJH (Escherichiacoli) |
PF00294(PfkB) | 5 | ALA A 11GLY A 10ILE A 45GLY A 42ILE A 13 | None | 0.92A | 4eatB-3in1A:3.1 | 4eatB-3in1A:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j7a | 40S RIBOSOMALPROTEIN US5 (Plasmodiumfalciparum) |
PF00333(Ribosomal_S5)PF03719(Ribosomal_S5_C) | 5 | ALA G 112ALA G 144ILE G 142GLY G 139ILE G 141 | None | 1.02A | 4eatB-3j7aG:undetectable | 4eatB-3j7aG:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k1j | ATP-DEPENDENTPROTEASE LON (Thermococcusonnurineus) |
PF01078(Mg_chelatase)PF05362(Lon_C)PF13654(AAA_32) | 5 | ALA A 464GLY A 472ILE A 474HIS A 509ILE A 475 | None | 1.14A | 4eatB-3k1jA:undetectable | 4eatB-3k1jA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l6c | SERINE RACEMASE (Rattusnorvegicus) |
PF00291(PALP) | 5 | ALA A 167GLY A 162ILE A 160GLY A 192ILE A 195 | None | 1.09A | 4eatB-3l6cA:undetectable | 4eatB-3l6cA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l6r | SERINE RACEMASE (Homo sapiens) |
PF00291(PALP) | 5 | ALA A 167GLY A 162ILE A 160GLY A 192ILE A 195 | None | 1.08A | 4eatB-3l6rA:undetectable | 4eatB-3l6rA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mqg | LIPOPOLYSACCHARIDESBIOSYNTHESISACETYLTRANSFERASE (Bordetellapetrii) |
PF00132(Hexapep) | 5 | ALA A 141ALA A 107GLY A 106GLY A 122ILE A 121 | None | 1.14A | 4eatB-3mqgA:undetectable | 4eatB-3mqgA:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3my7 | ALCOHOLDEHYDROGENASE/ACETALDEHYDE DEHYDROGENASE (Vibrioparahaemolyticus) |
PF00171(Aldedh) | 5 | ALA A 19GLY A 168ILE A 134GLY A 133ILE A 106 | None | 0.99A | 4eatB-3my7A:2.4 | 4eatB-3my7A:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o04 | BETA-KETO-ACYLCARRIER PROTEINSYNTHASE II (Listeriamonocytogenes) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ALA A 191ALA A 13GLY A 12GLY A 347ILE A 348 | None | 1.14A | 4eatB-3o04A:undetectable | 4eatB-3o04A:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ph3 | RIBOSE-5-PHOSPHATEISOMERASE (Ruminiclostridiumthermocellum) |
PF02502(LacAB_rpiB) | 5 | ALA A 52GLY A 6ILE A 62GLY A 61ILE A 103 | None | 0.77A | 4eatB-3ph3A:2.5 | 4eatB-3ph3A:15.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3psf | TRANSCRIPTIONELONGATION FACTORSPT6 (Saccharomycescerevisiae) |
PF14635(HHH_7)PF14639(YqgF)PF14641(HTH_44)PF14878(DLD) | 5 | ALA A 881ALA A 810ILE A 846GLY A 812ILE A 847 | None | 1.05A | 4eatB-3psfA:undetectable | 4eatB-3psfA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3psi | TRANSCRIPTIONELONGATION FACTORSPT6 (Saccharomycescerevisiae) |
PF14635(HHH_7)PF14639(YqgF)PF14641(HTH_44)PF14878(DLD) | 5 | ALA A 881ALA A 810ILE A 846GLY A 812ILE A 847 | None | 1.03A | 4eatB-3psiA:2.4 | 4eatB-3psiA:16.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qgu | LL-DIAMINOPIMELATEAMINOTRANSFERASE (Chlamydomonasreinhardtii) |
PF00155(Aminotran_1_2) | 5 | ALA A 238ALA A 270GLY A 269ILE A 267ILE A 264 | None | 1.15A | 4eatB-3qguA:2.0 | 4eatB-3qguA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3upu | ATP-DEPENDENT DNAHELICASE DDA (Escherichiavirus T4) |
PF13604(AAA_30) | 5 | ALA A 398ALA A 406GLY A 432GLY A 428ILE A 408 | None | 1.08A | 4eatB-3upuA:3.0 | 4eatB-3upuA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3whi | SUBTILISIN E (Bacillussubtilis) |
PF00082(Peptidase_S8)PF05922(Inhibitor_I9) | 5 | ALA A 138ALA A 204ILE A 201GLY A 200ILE A 121 | None | 1.13A | 4eatB-3whiA:2.4 | 4eatB-3whiA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zpp | CELL WALL SURFACEANCHOR FAMILYPROTEIN (Streptococcuspneumoniae) |
PF12708(Pectate_lyase_3)PF13229(Beta_helix) | 5 | ALA A 343TYR A 342ALA A 272ILE A 273GLY A 274 | None | 0.92A | 4eatB-3zppA:undetectable | 4eatB-3zppA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a01 | PROTONPYROPHOSPHATASE (Vigna radiata) |
PF03030(H_PPase) | 5 | ALA A 486ALA A 414GLY A 415GLY A 546ILE A 466 | None | 0.97A | 4eatB-4a01A:undetectable | 4eatB-4a01A:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4axi | ETHANOLAMINECARBOXYSOMESTRUCTURAL PROTEIN (Clostridioidesdifficile) |
PF00936(BMC) | 5 | ALA A 94GLY A 86ILE A 46GLY A 47ILE A 24 | None | 0.94A | 4eatB-4axiA:undetectable | 4eatB-4axiA:12.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bem | F1FO ATPASE C2SUBUNITF1FO ATPASE C1SUBUNIT (Acetobacteriumwoodii;Acetobacteriumwoodii) |
PF00137(ATP-synt_C)PF00137(ATP-synt_C) | 5 | ALA J 161GLY A 22ILE J 123GLY J 124ILE A 27 | None | 1.08A | 4eatB-4bemJ:undetectable | 4eatB-4bemJ:16.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cw5 | DFNA (Bacillusvelezensis) |
PF03060(NMO) | 5 | ALA A 536ALA A 707GLY A 705GLY A 559ILE A 561 | FMN A1753 ( 3.3A)FMN A1753 (-3.6A)NoneFMN A1753 (-3.0A)None | 1.11A | 4eatB-4cw5A:undetectable | 4eatB-4cw5A:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e3a | SUGAR KINASE PROTEIN (Rhizobium etli) |
PF00294(PfkB) | 5 | ALA A 274GLY A 299ILE A 263GLY A 304ILE A 305 | None | 1.09A | 4eatB-4e3aA:2.2 | 4eatB-4e3aA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4euk | HISTIDINE KINASE 5 (Arabidopsisthaliana) |
PF00072(Response_reg) | 5 | ALA A 807ALA A 839GLY A 836ILE A 843ILE A 814 | None | 1.15A | 4eatB-4eukA:4.5 | 4eatB-4eukA:14.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g9b | BETA-PHOSPHOGLUCOMUTASE (Escherichiacoli) |
PF13419(HAD_2) | 5 | ALA A 115GLY A 5ILE A 168GLY A 169ILE A 170 | None | 1.06A | 4eatB-4g9bA:2.8 | 4eatB-4g9bA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h17 | HYDROLASE,ISOCHORISMATASEFAMILY (Pseudomonasputida) |
PF00857(Isochorismatase) | 5 | ALA A 47ALA A 30ILE A 28GLY A 129ILE A 27 | None | 1.05A | 4eatB-4h17A:4.2 | 4eatB-4h17A:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hcj | THIJ/PFPI DOMAINPROTEIN (Brachyspiramurdochii) |
PF01965(DJ-1_PfpI) | 5 | ALA A 165ALA A 102GLY A 103ILE A 150ILE A 100 | None | 1.11A | 4eatB-4hcjA:2.2 | 4eatB-4hcjA:15.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kq6 | 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE ([Candida]glabrata) |
PF00885(DMRL_synthase) | 5 | ALA A 157ALA A 39GLY A 150ILE A 88ILE A 22 | None | 1.14A | 4eatB-4kq6A:2.3 | 4eatB-4kq6A:14.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kyx | ADP-RIBOSEPYROPHOSPHATASE MUTT (Rickettsiafelis) |
PF00293(NUDIX) | 5 | ALA A 35GLY A 39ILE A 9GLY A 10ILE A 11 | None | 1.05A | 4eatB-4kyxA:undetectable | 4eatB-4kyxA:13.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ne4 | ABC TRANSPORTER,SUBSTRATE BINDINGPROTEIN(PROLINE/GLYCINE/BETAINE) (Agrobacteriumfabrum) |
PF04069(OpuAC) | 5 | ALA A 271ALA A 27ILE A 25GLY A 22ILE A 24 | None | 1.03A | 4eatB-4ne4A:3.4 | 4eatB-4ne4A:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nhd | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 PROTEIN 1 (Vibrio cholerae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | ALA A 66GLY A 7ILE A 63HIS A 133ILE A 68 | None | 1.14A | 4eatB-4nhdA:undetectable | 4eatB-4nhdA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4olo | BMC DOMAIN PROTEIN (Clostridialesbacterium1_7_47FAA) |
PF00936(BMC) | 6 | ALA A 86ALA A 34GLY A 78ILE A 35GLY A 36ILE A 5 | None | 1.10A | 4eatB-4oloA:undetectable | 4eatB-4oloA:12.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4olp | GRPUMICROCOMPARTMENTSHELL PROTEIN (Pectobacteriumparmentieri) |
PF00936(BMC) | 5 | ALA A 88GLY A 80ILE A 37GLY A 38ILE A 5 | None | 0.85A | 4eatB-4olpA:undetectable | 4eatB-4olpA:11.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ox6 | CARBON DIOXIDECONCENTRATINGMECHANISM PROTEINCCMK (Synechococcuselongatus) |
PF00936(BMC) | 5 | ALA A 57ALA A 5ILE A 6GLY A 7ILE A 78 | None | 1.14A | 4eatB-4ox6A:undetectable | 4eatB-4ox6A:13.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q6u | UNCHARACTERIZEDPROTEIN (Mycobacteriumtuberculosis) |
no annotation | 5 | ALA A 19ALA A 208ILE A 181GLY A 182ILE A 168 | None | 0.88A | 4eatB-4q6uA:undetectable | 4eatB-4q6uA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qnn | PHOSPHOLIPASE A 1 FROM HORNET(VESPABASALIS) VENOM (Vespa basalis) |
PF00151(Lipase) | 5 | GLY A 135ILE A 161GLY A 144HIS A 141ILE A 180 | None | 1.03A | 4eatB-4qnnA:2.9 | 4eatB-4qnnA:20.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4rlq | BENZOATE-COENZYME ALIGASE (Rhodopseudomonaspalustris) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 8 | ALA A 227TYR A 228ALA A 302GLY A 303ILE A 326GLY A 327HIS A 333ILE A 334 | 3SK A1000 (-3.6A)3SK A1000 (-4.8A)3SK A1000 ( 3.8A)3SK A1000 (-3.3A)3SK A1000 (-4.4A)3SK A1000 (-3.6A)3SK A1000 ( 4.1A)None | 0.16A | 4eatB-4rlqA:71.5 | 4eatB-4rlqA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4us4 | TRANSPORTER (Bacillushalodurans) |
PF00209(SNF) | 5 | ALA A 436GLY A 53ILE A 55GLY A 59ILE A 60 | None | 1.06A | 4eatB-4us4A:undetectable | 4eatB-4us4A:24.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4wv3 | ANTHRANILATE-COALIGASE (Stigmatellaaurantiaca) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | ALA A 293ILE A 317GLY A 318HIS A 324ILE A 325 | 3UK A 601 (-3.5A)3UK A 601 (-4.0A)3UK A 601 (-3.5A)3UK A 601 (-3.6A)None | 0.30A | 4eatB-4wv3A:57.5 | 4eatB-4wv3A:42.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zoh | PUTATIVEOXIDOREDUCTASEMOLYBDOPTERIN-BINDING SUBUNIT (Sulfurisphaeratokodaii) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 5 | ALA A 334TYR A 331ALA A 162GLY A 253GLY A 216 | NoneNoneNoneNone MO A 802 ( 3.9A) | 0.96A | 4eatB-4zohA:undetectable | 4eatB-4zohA:24.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b37 | TRYPTOPHANDEHYDROGENASE (Nostocpunctiforme) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | ALA A 255ALA A 285GLY A 287GLY A 149ILE A 310 | None | 1.01A | 4eatB-5b37A:5.8 | 4eatB-5b37A:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d04 | PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATEALDOLASE (Neisseriameningitidis) |
PF00793(DAHP_synth_1) | 5 | ALA C 252ALA C 258GLY C 259ILE C 202ILE C 199 | None | 1.14A | 4eatB-5d04C:undetectable | 4eatB-5d04C:23.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dkx | ALPHAGLUCOSIDASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF17137(DUF5110) | 5 | ALA A 733ALA A 394GLY A 398GLY A 655ILE A 390 | None | 1.09A | 4eatB-5dkxA:2.6 | 4eatB-5dkxA:20.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fji | BETA-GLUCOSIDASE (Aspergillusfumigatus) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | ALA A 595ALA A 572GLY A 573ILE A 549ILE A 570 | None | 1.13A | 4eatB-5fjiA:2.5 | 4eatB-5fjiA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gka | GENOME POLYPROTEIN (Aichivirus A) |
PF00073(Rhv) | 5 | ALA C 56ALA C 85GLY C 84ILE C 80ILE C 205 | None | 0.99A | 4eatB-5gkaC:undetectable | 4eatB-5gkaC:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5im4 | 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE (Candidaalbicans) |
PF00885(DMRL_synthase) | 5 | ALA A 156ALA A 39GLY A 149ILE A 88ILE A 22 | None | 1.08A | 4eatB-5im4A:3.3 | 4eatB-5im4A:14.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iuy | MULTIDRUG EFFLUXOUTER MEMBRANEPROTEIN OPRN (Pseudomonasaeruginosa) |
PF02321(OEP) | 5 | ALA A 88ALA A 303GLY A 304GLY A 306ILE A 309 | None | 0.98A | 4eatB-5iuyA:undetectable | 4eatB-5iuyA:24.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mux | 2-METHYLCITRATEDEHYDRATASE (Bacillussubtilis) |
no annotation | 5 | ALA A 217GLY A 111ILE A 84GLY A 85ILE A 88 | None | 1.13A | 4eatB-5muxA:undetectable | 4eatB-5muxA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ngd | PORTAL PROTEIN (Thermus virusP74-26) |
no annotation | 5 | ALA A 71TYR A 74GLY A 77ILE A 79ILE A 341 | None | 1.01A | 4eatB-5ngdA:undetectable | 4eatB-5ngdA:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nsq | AMINOPEPTIDASE,PUTATIVE (Trypanosomabrucei) |
PF00883(Peptidase_M17) | 5 | TYR A 351GLY A 260ILE A 256GLY A 255ILE A 376 | None | 1.05A | 4eatB-5nsqA:3.6 | 4eatB-5nsqA:24.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nth | PUTATIVEAMINOPEPTIDASE (Leishmaniamajor) |
PF00883(Peptidase_M17) | 5 | TYR A 369GLY A 268ILE A 264GLY A 263ILE A 394 | None | 1.00A | 4eatB-5nthA:3.0 | 4eatB-5nthA:24.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o60 | 50S RIBOSOMALPROTEIN L5 (Mycolicibacteriumsmegmatis) |
PF00281(Ribosomal_L5)PF00673(Ribosomal_L5_C) | 5 | ALA F 60ALA F 50GLY F 48ILE F 92GLY F 93 | NoneNone G A2531 ( 3.5A) U A2536 ( 4.1A) U A2536 ( 4.1A) | 1.07A | 4eatB-5o60F:undetectable | 4eatB-5o60F:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oe5 | ANTHRANILATE--COALIGASE (Pseudomonasaeruginosa) |
PF00501(AMP-binding) | 6 | TYR A 211ALA A 278GLY A 279ILE A 301GLY A 302HIS A 308 | 3UK A 900 (-4.0A)3UK A 900 ( 2.9A)3UK A 900 (-3.2A)3UK A 900 (-4.0A)3UK A 900 (-3.4A)3UK A 900 ( 2.8A) | 0.34A | 4eatB-5oe5A:49.4 | 4eatB-5oe5A:28.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u25 | DIHYDROLIPOAMIDEDEHYDROGENASE (E3COMPONENT OFPYRUVATE AND2-OXOGLUTARATEDEHYDROGENASECOMPLEXES) (Neisseriagonorrhoeae) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ALA A 432ALA A 267GLY A 268GLY A 399ILE A 402 | NoneFAD A 601 (-3.8A)FAD A 601 (-3.4A)NoneFAD A 601 ( 4.9A) | 1.07A | 4eatB-5u25A:2.3 | 4eatB-5u25A:21.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5u2a | AMP-DEPENDENTSYNTHETASE ANDLIGASE (Brucella canis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | ALA A 250TYR A 251ALA A 322GLY A 323GLY A 347 | None | 0.73A | 4eatB-5u2aA:43.0 | 4eatB-5u2aA:32.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ux9 | CHLORAMPHENICOLACETYLTRANSFERASE (Aliivibriofischeri) |
PF00132(Hexapep) | 5 | ALA A 149ALA A 80GLY A 79GLY A 128ILE A 127 | None | 1.05A | 4eatB-5ux9A:undetectable | 4eatB-5ux9A:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w1j | THIOREDOXINGLUTATHIONEREDUCTASE (Echinococcusgranulosus) |
no annotation | 5 | ALA A 125ALA A 256GLY A 116GLY A 120ILE A 430 | NoneNoneFAD A 601 (-3.1A)FAD A 601 (-3.7A)None | 1.15A | 4eatB-5w1jA:undetectable | 4eatB-5w1jA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp6 | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY MMEMBER 4 (Homo sapiens) |
no annotation | 5 | ALA A 307GLY A 126ILE A 162GLY A 123ILE A 278 | None | 1.10A | 4eatB-5wp6A:undetectable | 4eatB-5wp6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xxu | RIBOSOMAL PROTEINUS5 (Toxoplasmagondii) |
PF00333(Ribosomal_S5)PF03719(Ribosomal_S5_C) | 5 | ALA C 108ALA C 140ILE C 138GLY C 135ILE C 137 | None | 0.98A | 4eatB-5xxuC:undetectable | 4eatB-5xxuC:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dg4 | ULP1-LIKE SUMOPROTEASE (Chaetomiumthermophilum) |
no annotation | 5 | ALA A 236ALA A 68GLY A 67ILE A 65ILE A 207 | None | 1.05A | 4eatB-6dg4A:undetectable | 4eatB-6dg4A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gne | - (-) |
no annotation | 5 | ALA A 168TYR A 171ALA A 183ILE A 156ILE A 157 | None | 1.13A | 4eatB-6gneA:2.7 | 4eatB-6gneA:undetectable |