SIMILAR PATTERNS OF AMINO ACIDS FOR 4EAT_B_BEZB1000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al8 GLYCOLATE OXIDASE

(Spinacia
oleracea)
PF01070
(FMN_dh)
5 ALA A 302
ALA A 276
GLY A 278
ILE A 280
ILE A 249
None
1.07A 4eatB-1al8A:
undetectable
4eatB-1al8A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ejb LUMAZINE SYNTHASE

(Saccharomyces
cerevisiae)
PF00885
(DMRL_synthase)
5 ALA A 156
ALA A  38
GLY A 149
ILE A  87
ILE A  21
None
1.14A 4eatB-1ejbA:
3.1
4eatB-1ejbA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0u PROTEASOME COMPONENT
PUP2


(Saccharomyces
cerevisiae)
PF00227
(Proteasome)
PF10584
(Proteasome_A_N)
5 ALA D  41
TYR D 146
GLY D 145
GLY D 140
ILE D 215
None
1.05A 4eatB-1g0uD:
undetectable
4eatB-1g0uD:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ghs 1,3-BETA-GLUCANASE

(Hordeum vulgare)
PF00332
(Glyco_hydro_17)
5 ALA A 247
TYR A 250
GLY A 253
ILE A 255
ILE A 273
None
1.08A 4eatB-1ghsA:
undetectable
4eatB-1ghsA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3e TYROSYL-TRNA
SYNTHETASE


(Thermus
thermophilus)
PF00579
(tRNA-synt_1b)
5 ALA A 112
TYR A 108
ALA A  44
ILE A  75
ILE A  76
None
None
ATP  A1433 (-3.8A)
TYE  A1434 ( 3.9A)
None
1.15A 4eatB-1h3eA:
undetectable
4eatB-1h3eA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT


(Klebsiella
pneumoniae)
PF02286
(Dehydratase_LU)
5 ALA A 162
ALA A 416
GLY A 190
GLY A 194
ILE A 412
None
1.13A 4eatB-1iwpA:
undetectable
4eatB-1iwpA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jbi COCHLIN

(Homo sapiens)
PF03815
(LCCL)
5 ALA A  42
TYR A  41
ALA A  50
GLY A  49
ILE A  47
None
1.06A 4eatB-1jbiA:
undetectable
4eatB-1jbiA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kz1 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE


(Schizosaccharomyces
pombe)
PF00885
(DMRL_synthase)
5 ALA A 150
ALA A  39
GLY A 143
ILE A  84
ILE A  22
None
1.14A 4eatB-1kz1A:
2.0
4eatB-1kz1A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x53 ACTIVATOR OF 90 KDA
HEAT SHOCK PROTEIN
ATPASE HOMOLOG 1


(Homo sapiens)
PF08327
(AHSA1)
5 ALA A  89
GLY A 110
ILE A  13
GLY A 108
ILE A  91
None
1.07A 4eatB-1x53A:
undetectable
4eatB-1x53A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xat XENOBIOTIC
ACETYLTRANSFERASE


(Pseudomonas
aeruginosa)
PF00132
(Hexapep)
5 ALA A 141
ALA A  69
GLY A  68
GLY A 120
ILE A 119
None
1.12A 4eatB-1xatA:
undetectable
4eatB-1xatA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae)
PF01593
(Amino_oxidase)
5 ALA A  23
ALA A 492
GLY A 478
GLY A  17
ILE A  18
None
FAD  A 803 (-3.3A)
FAD  A 803 (-2.9A)
FAD  A 803 (-3.6A)
FAD  A 803 (-4.7A)
1.12A 4eatB-1yy5A:
undetectable
4eatB-1yy5A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfc 2-(R)-HYDROXYPROPYL-
COM DEHYDROGENASE


(Xanthobacter
autotrophicus)
PF13561
(adh_short_C2)
5 ALA A 249
TYR A 247
GLY A 186
GLY A 245
ILE A 210
None
None
KPC  A1252 (-4.7A)
None
None
1.05A 4eatB-2cfcA:
undetectable
4eatB-2cfcA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chg REPLICATION FACTOR C
SMALL SUBUNIT


(Archaeoglobus
fulgidus)
PF00004
(AAA)
5 ALA A 207
ALA A 188
GLY A 185
ILE A 190
ILE A 192
None
1.15A 4eatB-2chgA:
undetectable
4eatB-2chgA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d57 AQUAPORIN-4

(Rattus
norvegicus)
PF00230
(MIP)
5 ALA A 215
ALA A 130
ILE A 128
GLY A 125
ILE A 127
None
0.98A 4eatB-2d57A:
undetectable
4eatB-2d57A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dst HYPOTHETICAL PROTEIN
TTHA1544


(Thermus
thermophilus)
no annotation 5 ALA A  67
ALA A  92
GLY A  90
GLY A  94
HIS A  96
None
1.15A 4eatB-2dstA:
3.4
4eatB-2dstA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2euh NADP DEPENDENT NON
PHOSPHORYLATING
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Streptococcus
mutans)
PF00171
(Aldedh)
5 ALA A 452
GLY A 230
ILE A 234
GLY A 235
ILE A 238
None
NAP  A 476 (-3.1A)
NAP  A 476 (-3.8A)
None
None
1.12A 4eatB-2euhA:
2.6
4eatB-2euhA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew7 PEPTIDE DEFORMYLASE

(Helicobacter
pylori)
PF01327
(Pep_deformylase)
5 ALA A  48
ALA A 135
ILE A  45
GLY A  46
ILE A  61
None
1.13A 4eatB-2ew7A:
undetectable
4eatB-2ew7A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4n HYPOTHETICAL PROTEIN
MJ1651


(Methanocaldococcus
jannaschii)
PF01887
(SAM_adeno_trans)
5 ALA A 116
ALA A  64
ILE A  60
GLY A 110
ILE A 168
None
0.87A 4eatB-2f4nA:
undetectable
4eatB-2f4nA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g40 CONSERVED
HYPOTHETICAL PROTEIN


(Deinococcus
radiodurans)
PF02589
(LUD_dom)
5 ALA A  64
ALA A  70
GLY A  69
ILE A  71
ILE A 209
None
0.98A 4eatB-2g40A:
undetectable
4eatB-2g40A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jax HYPOTHETICAL PROTEIN
TB31.7


(Mycobacterium
tuberculosis)
PF00582
(Usp)
5 ALA A  27
ALA A  20
GLY A 117
GLY A  13
ILE A  14
None
ATP  A1296 (-2.6A)
ATP  A1296 (-2.5A)
ATP  A1296 (-3.3A)
None
1.11A 4eatB-2jaxA:
undetectable
4eatB-2jaxA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jqj DNA DAMAGE RESPONSE
PROTEIN KINASE DUN1


(Saccharomyces
cerevisiae)
PF00498
(FHA)
5 ALA A  78
ILE A  67
GLY A  59
HIS A  77
ILE A  73
None
1.12A 4eatB-2jqjA:
undetectable
4eatB-2jqjA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpk CHITIN SYNTHASE 1

(Saprolegnia
monoica)
PF04212
(MIT)
5 ALA A  26
TYR A  23
ALA A  17
ILE A  15
ILE A  71
None
1.09A 4eatB-2mpkA:
undetectable
4eatB-2mpkA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE


(Deinococcus
radiodurans)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N)
5 ALA A 516
ALA A 607
GLY A 608
GLY A 589
ILE A 590
None
0.97A 4eatB-2o1xA:
undetectable
4eatB-2o1xA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9w MAL S 1 ALLERGENIC
PROTEIN


(Malassezia
sympodialis)
no annotation 6 ALA A 177
TYR A 209
GLY A 225
ILE A 260
GLY A 211
ILE A 212
None
1.17A 4eatB-2p9wA:
undetectable
4eatB-2p9wA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE


(Escherichia
virus N4)
no annotation 5 ALA A 819
ALA A 915
GLY A 916
GLY A 919
ILE A 882
None
0.94A 4eatB-2po4A:
undetectable
4eatB-2po4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3o 12-OXOPHYTODIENOATE
REDUCTASE 3


(Arabidopsis
thaliana)
PF00724
(Oxidored_FMN)
5 ALA A 276
GLY A 231
ILE A 176
GLY A 182
ILE A 183
None
1.10A 4eatB-2q3oA:
undetectable
4eatB-2q3oA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9r PROTEIN OF UNKNOWN
FUNCTION


(Shewanella
baltica)
PF04222
(DUF416)
5 ALA A 100
ALA A 107
GLY A 106
ILE A 108
ILE A 116
None
1.10A 4eatB-2q9rA:
undetectable
4eatB-2q9rA:
16.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2v7b BENZOATE-COENZYME A
LIGASE


(Paraburkholderia
xenovorans)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
7 ALA A 237
TYR A 238
ALA A 308
GLY A 309
GLY A 333
HIS A 339
LYS A 520
BEZ  A1529 ( 3.7A)
BEZ  A1529 (-4.3A)
BEZ  A1529 (-3.6A)
BEZ  A1529 (-3.5A)
BEZ  A1529 (-3.6A)
BEZ  A1529 (-3.8A)
BEZ  A1529 (-2.9A)
1.18A 4eatB-2v7bA:
62.1
4eatB-2v7bA:
60.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2v7b BENZOATE-COENZYME A
LIGASE


(Paraburkholderia
xenovorans)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
8 ALA A 237
TYR A 238
ALA A 308
GLY A 309
ILE A 332
GLY A 333
HIS A 339
ILE A 340
BEZ  A1529 ( 3.7A)
BEZ  A1529 (-4.3A)
BEZ  A1529 (-3.6A)
BEZ  A1529 (-3.5A)
None
BEZ  A1529 (-3.6A)
BEZ  A1529 (-3.8A)
BEZ  A1529 ( 4.9A)
0.27A 4eatB-2v7bA:
62.1
4eatB-2v7bA:
60.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywx PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT


(Methanocaldococcus
jannaschii)
PF00731
(AIRC)
5 ALA A 119
ALA A  18
GLY A 112
ILE A  58
ILE A   4
None
1.08A 4eatB-2ywxA:
4.1
4eatB-2ywxA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186


(Pyrococcus
horikoshii)
PF06745
(ATPase)
5 ALA A  55
GLY A  54
ILE A  51
GLY A  62
ILE A  94
None
1.09A 4eatB-2ztsA:
2.3
4eatB-2ztsA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3d PUTATIVE MORPHINE
DEHYDROGENASE


(Bacillus
subtilis)
PF00248
(Aldo_ket_red)
5 ALA A  71
GLY A  72
ILE A  68
GLY A  67
ILE A  41
None
1.14A 4eatB-3b3dA:
undetectable
4eatB-3b3dA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3das PUTATIVE
OXIDOREDUCTASE


(Streptomyces
coelicolor)
PF07995
(GSDH)
5 ALA A 217
GLY A 206
GLY A 156
HIS A 201
ILE A 176
None
1.05A 4eatB-3dasA:
undetectable
4eatB-3dasA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddd PUTATIVE
ACETYLTRANSFERASE


(Pyrococcus
horikoshii)
PF00583
(Acetyltransf_1)
5 ALA A 176
ALA A 212
ILE A 208
GLY A 187
ILE A 194
None
1.08A 4eatB-3dddA:
undetectable
4eatB-3dddA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE


(Desulfovibrio
gigas)
PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
5 ALA A 537
ALA A 508
GLY A 507
ILE A 619
GLY A 620
None
1.12A 4eatB-3fahA:
2.4
4eatB-3fahA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk5 3-OXOACYL-SYNTHASE
III


(Xanthomonas
oryzae)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 ALA A 212
ALA A 241
ILE A 238
GLY A 237
ILE A 325
None
1.00A 4eatB-3fk5A:
undetectable
4eatB-3fk5A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7g UPF0311 PROTEIN
CA_C3321


(Clostridium
acetobutylicum)
PF11578
(DUF3237)
5 ALA A  78
ALA A  75
ILE A  60
GLY A  59
ILE A  41
None
0.91A 4eatB-3g7gA:
undetectable
4eatB-3g7gA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvx GLYCERATE
DEHYDROGENASE
RELATED PROTEIN


(Thermoplasma
acidophilum)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 ALA A 138
ALA A 180
GLY A 129
GLY A 132
ILE A 133
None
1.15A 4eatB-3gvxA:
6.0
4eatB-3gvxA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A


(Aquifex
aeolicus)
PF01425
(Amidase)
5 ALA A  50
ALA A 109
GLY A 108
ILE A  67
ILE A  69
None
1.05A 4eatB-3h0lA:
undetectable
4eatB-3h0lA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hee RIBOSE-5-PHOSPHATE
ISOMERASE


(Ruminiclostridium
thermocellum)
PF02502
(LacAB_rpiB)
5 ALA A  52
GLY A   6
ILE A  62
GLY A  61
ILE A 103
None
0.77A 4eatB-3heeA:
undetectable
4eatB-3heeA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE


(Jannaschia sp.
CCS1)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ALA A   9
GLY A  10
ILE A   8
GLY A  81
ILE A   7
None
1.09A 4eatB-3i6tA:
undetectable
4eatB-3i6tA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN

(Homo sapiens)
PF00514
(Arm)
5 ALA A 566
GLY A 565
ILE A 502
GLY A 503
ILE A 505
None
0.95A 4eatB-3ifqA:
undetectable
4eatB-3ifqA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in1 UNCHARACTERIZED
SUGAR KINASE YDJH


(Escherichia
coli)
PF00294
(PfkB)
5 ALA A  11
GLY A  10
ILE A  45
GLY A  42
ILE A  13
None
0.92A 4eatB-3in1A:
3.1
4eatB-3in1A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US5


(Plasmodium
falciparum)
PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C)
5 ALA G 112
ALA G 144
ILE G 142
GLY G 139
ILE G 141
None
1.02A 4eatB-3j7aG:
undetectable
4eatB-3j7aG:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON


(Thermococcus
onnurineus)
PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32)
5 ALA A 464
GLY A 472
ILE A 474
HIS A 509
ILE A 475
None
1.14A 4eatB-3k1jA:
undetectable
4eatB-3k1jA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6c SERINE RACEMASE

(Rattus
norvegicus)
PF00291
(PALP)
5 ALA A 167
GLY A 162
ILE A 160
GLY A 192
ILE A 195
None
1.09A 4eatB-3l6cA:
undetectable
4eatB-3l6cA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6r SERINE RACEMASE

(Homo sapiens)
PF00291
(PALP)
5 ALA A 167
GLY A 162
ILE A 160
GLY A 192
ILE A 195
None
1.08A 4eatB-3l6rA:
undetectable
4eatB-3l6rA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqg LIPOPOLYSACCHARIDES
BIOSYNTHESIS
ACETYLTRANSFERASE


(Bordetella
petrii)
PF00132
(Hexapep)
5 ALA A 141
ALA A 107
GLY A 106
GLY A 122
ILE A 121
None
1.14A 4eatB-3mqgA:
undetectable
4eatB-3mqgA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE


(Vibrio
parahaemolyticus)
PF00171
(Aldedh)
5 ALA A  19
GLY A 168
ILE A 134
GLY A 133
ILE A 106
None
0.99A 4eatB-3my7A:
2.4
4eatB-3my7A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II


(Listeria
monocytogenes)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 ALA A 191
ALA A  13
GLY A  12
GLY A 347
ILE A 348
None
1.14A 4eatB-3o04A:
undetectable
4eatB-3o04A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE


(Ruminiclostridium
thermocellum)
PF02502
(LacAB_rpiB)
5 ALA A  52
GLY A   6
ILE A  62
GLY A  61
ILE A 103
None
0.77A 4eatB-3ph3A:
2.5
4eatB-3ph3A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6


(Saccharomyces
cerevisiae)
PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD)
5 ALA A 881
ALA A 810
ILE A 846
GLY A 812
ILE A 847
None
1.05A 4eatB-3psfA:
undetectable
4eatB-3psfA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6


(Saccharomyces
cerevisiae)
PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD)
5 ALA A 881
ALA A 810
ILE A 846
GLY A 812
ILE A 847
None
1.03A 4eatB-3psiA:
2.4
4eatB-3psiA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgu LL-DIAMINOPIMELATE
AMINOTRANSFERASE


(Chlamydomonas
reinhardtii)
PF00155
(Aminotran_1_2)
5 ALA A 238
ALA A 270
GLY A 269
ILE A 267
ILE A 264
None
1.15A 4eatB-3qguA:
2.0
4eatB-3qguA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upu ATP-DEPENDENT DNA
HELICASE DDA


(Escherichia
virus T4)
PF13604
(AAA_30)
5 ALA A 398
ALA A 406
GLY A 432
GLY A 428
ILE A 408
None
1.08A 4eatB-3upuA:
3.0
4eatB-3upuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whi SUBTILISIN E

(Bacillus
subtilis)
PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9)
5 ALA A 138
ALA A 204
ILE A 201
GLY A 200
ILE A 121
None
1.13A 4eatB-3whiA:
2.4
4eatB-3whiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN


(Streptococcus
pneumoniae)
PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix)
5 ALA A 343
TYR A 342
ALA A 272
ILE A 273
GLY A 274
None
0.92A 4eatB-3zppA:
undetectable
4eatB-3zppA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE


(Vigna radiata)
PF03030
(H_PPase)
5 ALA A 486
ALA A 414
GLY A 415
GLY A 546
ILE A 466
None
0.97A 4eatB-4a01A:
undetectable
4eatB-4a01A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axi ETHANOLAMINE
CARBOXYSOME
STRUCTURAL PROTEIN


(Clostridioides
difficile)
PF00936
(BMC)
5 ALA A  94
GLY A  86
ILE A  46
GLY A  47
ILE A  24
None
0.94A 4eatB-4axiA:
undetectable
4eatB-4axiA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bem F1FO ATPASE C2
SUBUNIT
F1FO ATPASE C1
SUBUNIT


(Acetobacterium
woodii;
Acetobacterium
woodii)
PF00137
(ATP-synt_C)
PF00137
(ATP-synt_C)
5 ALA J 161
GLY A  22
ILE J 123
GLY J 124
ILE A  27
None
1.08A 4eatB-4bemJ:
undetectable
4eatB-4bemJ:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw5 DFNA

(Bacillus
velezensis)
PF03060
(NMO)
5 ALA A 536
ALA A 707
GLY A 705
GLY A 559
ILE A 561
FMN  A1753 ( 3.3A)
FMN  A1753 (-3.6A)
None
FMN  A1753 (-3.0A)
None
1.11A 4eatB-4cw5A:
undetectable
4eatB-4cw5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli)
PF00294
(PfkB)
5 ALA A 274
GLY A 299
ILE A 263
GLY A 304
ILE A 305
None
1.09A 4eatB-4e3aA:
2.2
4eatB-4e3aA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euk HISTIDINE KINASE 5

(Arabidopsis
thaliana)
PF00072
(Response_reg)
5 ALA A 807
ALA A 839
GLY A 836
ILE A 843
ILE A 814
None
1.15A 4eatB-4eukA:
4.5
4eatB-4eukA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9b BETA-PHOSPHOGLUCOMUT
ASE


(Escherichia
coli)
PF13419
(HAD_2)
5 ALA A 115
GLY A   5
ILE A 168
GLY A 169
ILE A 170
None
1.06A 4eatB-4g9bA:
2.8
4eatB-4g9bA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h17 HYDROLASE,
ISOCHORISMATASE
FAMILY


(Pseudomonas
putida)
PF00857
(Isochorismatase)
5 ALA A  47
ALA A  30
ILE A  28
GLY A 129
ILE A  27
None
1.05A 4eatB-4h17A:
4.2
4eatB-4h17A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcj THIJ/PFPI DOMAIN
PROTEIN


(Brachyspira
murdochii)
PF01965
(DJ-1_PfpI)
5 ALA A 165
ALA A 102
GLY A 103
ILE A 150
ILE A 100
None
1.11A 4eatB-4hcjA:
2.2
4eatB-4hcjA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq6 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE


([Candida]
glabrata)
PF00885
(DMRL_synthase)
5 ALA A 157
ALA A  39
GLY A 150
ILE A  88
ILE A  22
None
1.14A 4eatB-4kq6A:
2.3
4eatB-4kq6A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kyx ADP-RIBOSE
PYROPHOSPHATASE MUTT


(Rickettsia
felis)
PF00293
(NUDIX)
5 ALA A  35
GLY A  39
ILE A   9
GLY A  10
ILE A  11
None
1.05A 4eatB-4kyxA:
undetectable
4eatB-4kyxA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ne4 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(PROLINE/GLYCINE/BET
AINE)


(Agrobacterium
fabrum)
PF04069
(OpuAC)
5 ALA A 271
ALA A  27
ILE A  25
GLY A  22
ILE A  24
None
1.03A 4eatB-4ne4A:
3.4
4eatB-4ne4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 1


(Vibrio cholerae)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 ALA A  66
GLY A   7
ILE A  63
HIS A 133
ILE A  68
None
1.14A 4eatB-4nhdA:
undetectable
4eatB-4nhdA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4olo BMC DOMAIN PROTEIN

(Clostridiales
bacterium
1_7_47FAA)
PF00936
(BMC)
6 ALA A  86
ALA A  34
GLY A  78
ILE A  35
GLY A  36
ILE A   5
None
1.10A 4eatB-4oloA:
undetectable
4eatB-4oloA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4olp GRPU
MICROCOMPARTMENT
SHELL PROTEIN


(Pectobacterium
parmentieri)
PF00936
(BMC)
5 ALA A  88
GLY A  80
ILE A  37
GLY A  38
ILE A   5
None
0.85A 4eatB-4olpA:
undetectable
4eatB-4olpA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox6 CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN
CCMK


(Synechococcus
elongatus)
PF00936
(BMC)
5 ALA A  57
ALA A   5
ILE A   6
GLY A   7
ILE A  78
None
1.14A 4eatB-4ox6A:
undetectable
4eatB-4ox6A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6u UNCHARACTERIZED
PROTEIN


(Mycobacterium
tuberculosis)
no annotation 5 ALA A  19
ALA A 208
ILE A 181
GLY A 182
ILE A 168
None
0.88A 4eatB-4q6uA:
undetectable
4eatB-4q6uA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnn PHOSPHOLIPASE A 1
FROM HORNET(VESPA
BASALIS) VENOM


(Vespa basalis)
PF00151
(Lipase)
5 GLY A 135
ILE A 161
GLY A 144
HIS A 141
ILE A 180
None
1.03A 4eatB-4qnnA:
2.9
4eatB-4qnnA:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rlq BENZOATE-COENZYME A
LIGASE


(Rhodopseudomonas
palustris)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
8 ALA A 227
TYR A 228
ALA A 302
GLY A 303
ILE A 326
GLY A 327
HIS A 333
ILE A 334
3SK  A1000 (-3.6A)
3SK  A1000 (-4.8A)
3SK  A1000 ( 3.8A)
3SK  A1000 (-3.3A)
3SK  A1000 (-4.4A)
3SK  A1000 (-3.6A)
3SK  A1000 ( 4.1A)
None
0.16A 4eatB-4rlqA:
71.5
4eatB-4rlqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans)
PF00209
(SNF)
5 ALA A 436
GLY A  53
ILE A  55
GLY A  59
ILE A  60
None
1.06A 4eatB-4us4A:
undetectable
4eatB-4us4A:
24.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wv3 ANTHRANILATE-COA
LIGASE


(Stigmatella
aurantiaca)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 ALA A 293
ILE A 317
GLY A 318
HIS A 324
ILE A 325
3UK  A 601 (-3.5A)
3UK  A 601 (-4.0A)
3UK  A 601 (-3.5A)
3UK  A 601 (-3.6A)
None
0.30A 4eatB-4wv3A:
57.5
4eatB-4wv3A:
42.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT


(Sulfurisphaera
tokodaii)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
5 ALA A 334
TYR A 331
ALA A 162
GLY A 253
GLY A 216
None
None
None
None
MO  A 802 ( 3.9A)
0.96A 4eatB-4zohA:
undetectable
4eatB-4zohA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b37 TRYPTOPHAN
DEHYDROGENASE


(Nostoc
punctiforme)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 ALA A 255
ALA A 285
GLY A 287
GLY A 149
ILE A 310
None
1.01A 4eatB-5b37A:
5.8
4eatB-5b37A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d04 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE


(Neisseria
meningitidis)
PF00793
(DAHP_synth_1)
5 ALA C 252
ALA C 258
GLY C 259
ILE C 202
ILE C 199
None
1.14A 4eatB-5d04C:
undetectable
4eatB-5d04C:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110)
5 ALA A 733
ALA A 394
GLY A 398
GLY A 655
ILE A 390
None
1.09A 4eatB-5dkxA:
2.6
4eatB-5dkxA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
5 ALA A 595
ALA A 572
GLY A 573
ILE A 549
ILE A 570
None
1.13A 4eatB-5fjiA:
2.5
4eatB-5fjiA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gka GENOME POLYPROTEIN

(Aichivirus A)
PF00073
(Rhv)
5 ALA C  56
ALA C  85
GLY C  84
ILE C  80
ILE C 205
None
0.99A 4eatB-5gkaC:
undetectable
4eatB-5gkaC:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im4 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE


(Candida
albicans)
PF00885
(DMRL_synthase)
5 ALA A 156
ALA A  39
GLY A 149
ILE A  88
ILE A  22
None
1.08A 4eatB-5im4A:
3.3
4eatB-5im4A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN


(Pseudomonas
aeruginosa)
PF02321
(OEP)
5 ALA A  88
ALA A 303
GLY A 304
GLY A 306
ILE A 309
None
0.98A 4eatB-5iuyA:
undetectable
4eatB-5iuyA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE


(Bacillus
subtilis)
no annotation 5 ALA A 217
GLY A 111
ILE A  84
GLY A  85
ILE A  88
None
1.13A 4eatB-5muxA:
undetectable
4eatB-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngd PORTAL PROTEIN

(Thermus virus
P74-26)
no annotation 5 ALA A  71
TYR A  74
GLY A  77
ILE A  79
ILE A 341
None
1.01A 4eatB-5ngdA:
undetectable
4eatB-5ngdA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nsq AMINOPEPTIDASE,
PUTATIVE


(Trypanosoma
brucei)
PF00883
(Peptidase_M17)
5 TYR A 351
GLY A 260
ILE A 256
GLY A 255
ILE A 376
None
1.05A 4eatB-5nsqA:
3.6
4eatB-5nsqA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nth PUTATIVE
AMINOPEPTIDASE


(Leishmania
major)
PF00883
(Peptidase_M17)
5 TYR A 369
GLY A 268
ILE A 264
GLY A 263
ILE A 394
None
1.00A 4eatB-5nthA:
3.0
4eatB-5nthA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o60 50S RIBOSOMAL
PROTEIN L5


(Mycolicibacterium
smegmatis)
PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C)
5 ALA F  60
ALA F  50
GLY F  48
ILE F  92
GLY F  93
None
None
G  A2531 ( 3.5A)
U  A2536 ( 4.1A)
U  A2536 ( 4.1A)
1.07A 4eatB-5o60F:
undetectable
4eatB-5o60F:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oe5 ANTHRANILATE--COA
LIGASE


(Pseudomonas
aeruginosa)
PF00501
(AMP-binding)
6 TYR A 211
ALA A 278
GLY A 279
ILE A 301
GLY A 302
HIS A 308
3UK  A 900 (-4.0A)
3UK  A 900 ( 2.9A)
3UK  A 900 (-3.2A)
3UK  A 900 (-4.0A)
3UK  A 900 (-3.4A)
3UK  A 900 ( 2.8A)
0.34A 4eatB-5oe5A:
49.4
4eatB-5oe5A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u25 DIHYDROLIPOAMIDE
DEHYDROGENASE (E3
COMPONENT OF
PYRUVATE AND
2-OXOGLUTARATE
DEHYDROGENASE
COMPLEXES)


(Neisseria
gonorrhoeae)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ALA A 432
ALA A 267
GLY A 268
GLY A 399
ILE A 402
None
FAD  A 601 (-3.8A)
FAD  A 601 (-3.4A)
None
FAD  A 601 ( 4.9A)
1.07A 4eatB-5u25A:
2.3
4eatB-5u25A:
21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE


(Brucella canis)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 ALA A 250
TYR A 251
ALA A 322
GLY A 323
GLY A 347
None
0.73A 4eatB-5u2aA:
43.0
4eatB-5u2aA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux9 CHLORAMPHENICOL
ACETYLTRANSFERASE


(Aliivibrio
fischeri)
PF00132
(Hexapep)
5 ALA A 149
ALA A  80
GLY A  79
GLY A 128
ILE A 127
None
1.05A 4eatB-5ux9A:
undetectable
4eatB-5ux9A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1j THIOREDOXIN
GLUTATHIONE
REDUCTASE


(Echinococcus
granulosus)
no annotation 5 ALA A 125
ALA A 256
GLY A 116
GLY A 120
ILE A 430
None
None
FAD  A 601 (-3.1A)
FAD  A 601 (-3.7A)
None
1.15A 4eatB-5w1jA:
undetectable
4eatB-5w1jA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4


(Homo sapiens)
no annotation 5 ALA A 307
GLY A 126
ILE A 162
GLY A 123
ILE A 278
None
1.10A 4eatB-5wp6A:
undetectable
4eatB-5wp6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US5


(Toxoplasma
gondii)
PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C)
5 ALA C 108
ALA C 140
ILE C 138
GLY C 135
ILE C 137
None
0.98A 4eatB-5xxuC:
undetectable
4eatB-5xxuC:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dg4 ULP1-LIKE SUMO
PROTEASE


(Chaetomium
thermophilum)
no annotation 5 ALA A 236
ALA A  68
GLY A  67
ILE A  65
ILE A 207
None
1.05A 4eatB-6dg4A:
undetectable
4eatB-6dg4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-)
no annotation 5 ALA A 168
TYR A 171
ALA A 183
ILE A 156
ILE A 157
None
1.13A 4eatB-6gneA:
2.7
4eatB-6gneA:
undetectable